Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Ephrin A  reverse signaling	59.0	419.0	7.0	-0.05	0.001	1000.0	-1000.0	0.0	-1000.0
E-cadherin signaling events	51.0	255.0	5.0	-0.067	0.029	1000.0	-1000.0	0.02	-1000.0
TCR signaling in naïve CD8+ T cells	49.0	4580.0	93.0	-0.232	0.11	1000.0	-1000.0	-0.032	-1000.0
IL4-mediated signaling events	43.0	3994.0	91.0	-0.507	0.37	1000.0	-1000.0	-0.067	-1000.0
IL23-mediated signaling events	43.0	2590.0	60.0	-0.322	0.029	1000.0	-1000.0	-0.065	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	42.0	3160.0	74.0	-0.067	0.064	1000.0	-1000.0	-0.038	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	41.0	3213.0	78.0	-0.184	0.06	1000.0	-1000.0	-0.025	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	38.0	2646.0	68.0	-0.298	0.086	1000.0	-1000.0	-0.043	-1000.0
E-cadherin signaling in the nascent adherens junction	38.0	2951.0	76.0	-0.119	0.043	1000.0	-1000.0	-0.037	-1000.0
Angiopoietin receptor Tie2-mediated signaling	38.0	3383.0	88.0	-0.198	0.037	1000.0	-1000.0	-0.048	-1000.0
IL12-mediated signaling events	37.0	3286.0	87.0	-0.286	0.064	1000.0	-1000.0	-0.038	-1000.0
Signaling events regulated by Ret tyrosine kinase	36.0	2977.0	82.0	-0.053	0.034	1000.0	-1000.0	-0.03	-1000.0
Endothelins	36.0	3525.0	96.0	-0.121	0.051	1000.0	-1000.0	-0.02	-1000.0
Noncanonical Wnt signaling pathway	34.0	886.0	26.0	-0.036	0.028	1000.0	-1000.0	-0.022	-1000.0
Syndecan-1-mediated signaling events	33.0	1146.0	34.0	-0.051	0.029	1000.0	-1000.0	-0.012	-1000.0
BCR signaling pathway	33.0	3332.0	99.0	-0.16	0.035	1000.0	-1000.0	-0.055	-1000.0
Wnt signaling	32.0	225.0	7.0	-0.026	0.022	1000.0	-1000.0	0.004	-1000.0
E-cadherin signaling in keratinocytes	31.0	1353.0	43.0	-0.069	0.031	1000.0	-1000.0	-0.012	-1000.0
Nectin adhesion pathway	30.0	1930.0	63.0	-0.092	0.043	1000.0	-1000.0	-0.024	-1000.0
Integrins in angiogenesis	29.0	2499.0	84.0	-0.116	0.049	1000.0	-1000.0	-0.025	-1000.0
Osteopontin-mediated events	28.0	1101.0	38.0	-0.049	0.031	1000.0	-1000.0	-0.016	-1000.0
Glypican 1 network	28.0	1357.0	48.0	-0.04	0.039	1000.0	-1000.0	-0.021	-1000.0
Signaling mediated by p38-alpha and p38-beta	27.0	1192.0	44.0	-0.06	0.029	1000.0	-1000.0	-0.007	-1000.0
TCGA08_retinoblastoma	27.0	221.0	8.0	-0.006	0.047	1000.0	-1000.0	-0.006	-1000.0
Thromboxane A2 receptor signaling	26.0	2806.0	105.0	-0.086	0.034	1000.0	-1000.0	-0.022	-1000.0
LPA receptor mediated events	26.0	2750.0	102.0	-0.08	0.033	1000.0	-1000.0	-0.077	-1000.0
S1P4 pathway	26.0	659.0	25.0	-0.038	0.037	1000.0	-1000.0	-0.011	-1000.0
p75(NTR)-mediated signaling	25.0	3194.0	125.0	-0.048	0.073	1000.0	-1000.0	-0.036	-1000.0
Calcium signaling in the CD4+ TCR pathway	25.0	785.0	31.0	-0.087	0.029	1000.0	-1000.0	-0.032	-1000.0
Glucocorticoid receptor regulatory network	24.0	2809.0	114.0	-0.246	0.128	1000.0	-1000.0	-0.036	-1000.0
EPHB forward signaling	24.0	2122.0	85.0	-0.056	0.06	1000.0	-1000.0	-0.042	-1000.0
EGFR-dependent Endothelin signaling events	24.0	523.0	21.0	-0.038	0.041	1000.0	-1000.0	-0.029	-1000.0
Caspase cascade in apoptosis	23.0	1730.0	74.0	-0.062	0.04	1000.0	-1000.0	-0.033	-1000.0
HIF-1-alpha transcription factor network	23.0	1750.0	76.0	-0.027	0.065	1000.0	-1000.0	-0.01	-1000.0
a4b1 and a4b7 Integrin signaling	23.0	115.0	5.0	-0.0	0.017	1000.0	-1000.0	0.02	-1000.0
BMP receptor signaling	23.0	1934.0	81.0	-0.045	0.05	1000.0	-1000.0	-0.021	-1000.0
FAS signaling pathway (CD95)	23.0	1122.0	47.0	-0.048	0.037	1000.0	-1000.0	-0.029	-1000.0
IL27-mediated signaling events	23.0	1189.0	51.0	-0.15	0.101	1000.0	-1000.0	-0.043	-1000.0
JNK signaling in the CD4+ TCR pathway	21.0	366.0	17.0	-0.087	0.041	1000.0	-1000.0	-0.02	-1000.0
Signaling events mediated by PTP1B	21.0	1621.0	76.0	-0.059	0.043	1000.0	-1000.0	-0.034	-1000.0
Glypican 2 network	21.0	85.0	4.0	0.011	0.015	1000.0	-1000.0	0.019	-1000.0
Class IB PI3K non-lipid kinase events	21.0	63.0	3.0	-0.008	0.008	1000.0	-1000.0	-0.024	-1000.0
Arf6 signaling events	20.0	1248.0	62.0	-0.03	0.058	1000.0	-1000.0	-0.025	-1000.0
Ephrin B reverse signaling	20.0	978.0	48.0	-0.049	0.039	1000.0	-1000.0	-0.029	-1000.0
Reelin signaling pathway	19.0	1116.0	56.0	-0.031	0.056	1000.0	-1000.0	-0.019	-1000.0
S1P5 pathway	19.0	339.0	17.0	-0.037	0.033	1000.0	-1000.0	-0.004	-1000.0
IL2 signaling events mediated by PI3K	19.0	1115.0	58.0	-0.104	0.042	1000.0	-1000.0	-0.033	-1000.0
Effects of Botulinum toxin	19.0	508.0	26.0	-0.016	0.04	1000.0	-1000.0	-0.004	-1000.0
Syndecan-4-mediated signaling events	19.0	1294.0	67.0	-0.045	0.037	1000.0	-1000.0	-0.027	-1000.0
Plasma membrane estrogen receptor signaling	19.0	1704.0	86.0	-0.123	0.087	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by the Hedgehog family	18.0	970.0	52.0	-0.045	0.043	1000.0	-1000.0	-0.024	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	18.0	1566.0	85.0	-0.035	0.036	1000.0	-1000.0	-0.022	-1000.0
Fc-epsilon receptor I signaling in mast cells	18.0	1812.0	97.0	-0.051	0.049	1000.0	-1000.0	-0.039	-1000.0
amb2 Integrin signaling	18.0	1496.0	82.0	-0.037	0.041	1000.0	-1000.0	-0.018	-1000.0
Ceramide signaling pathway	18.0	1415.0	76.0	-0.041	0.041	1000.0	-1000.0	-0.017	-1000.0
TRAIL signaling pathway	18.0	879.0	48.0	-0.024	0.044	1000.0	-1000.0	-0.021	-1000.0
S1P1 pathway	18.0	661.0	36.0	-0.076	0.029	1000.0	-1000.0	-0.017	-1000.0
IFN-gamma pathway	17.0	1180.0	68.0	-0.032	0.037	1000.0	-1000.0	-0.03	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	17.0	918.0	52.0	-0.061	0.061	1000.0	-1000.0	-0.024	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	17.0	797.0	45.0	-0.047	0.059	1000.0	-1000.0	-0.037	-1000.0
Class I PI3K signaling events	17.0	1291.0	73.0	-0.092	0.051	1000.0	-1000.0	-0.019	-1000.0
ceramide signaling pathway	16.0	812.0	49.0	-0.027	0.041	1000.0	-1000.0	-0.029	-1000.0
IL2 signaling events mediated by STAT5	16.0	354.0	22.0	-0.04	0.029	1000.0	-1000.0	-0.017	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	16.0	1990.0	120.0	-0.089	0.069	1000.0	-1000.0	-0.035	-1000.0
ErbB2/ErbB3 signaling events	15.0	981.0	65.0	-0.032	0.041	1000.0	-1000.0	-0.052	-1000.0
TCGA08_p53	15.0	107.0	7.0	-0.013	0.024	1000.0	-1000.0	-0.001	-1000.0
Signaling mediated by p38-gamma and p38-delta	15.0	235.0	15.0	-0.023	0.027	1000.0	-1000.0	-0.019	-1000.0
Ras signaling in the CD4+ TCR pathway	15.0	269.0	17.0	-0.021	0.051	1000.0	-1000.0	-0.014	-1000.0
Syndecan-2-mediated signaling events	14.0	979.0	69.0	-0.019	0.043	1000.0	-1000.0	-0.021	-1000.0
IL1-mediated signaling events	14.0	914.0	62.0	-0.013	0.069	1000.0	-1000.0	-0.017	-1000.0
S1P3 pathway	14.0	602.0	42.0	-0.037	0.045	1000.0	-1000.0	-0.012	-1000.0
LPA4-mediated signaling events	13.0	163.0	12.0	-0.038	0.006	1000.0	-1000.0	-0.017	-1000.0
EPO signaling pathway	13.0	746.0	55.0	-0.001	0.05	1000.0	-1000.0	-0.016	-1000.0
Regulation of p38-alpha and p38-beta	13.0	715.0	54.0	-0.057	0.059	1000.0	-1000.0	-0.033	-1000.0
IL6-mediated signaling events	13.0	978.0	75.0	-0.03	0.069	1000.0	-1000.0	-0.037	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	12.0	684.0	54.0	-0.02	0.04	1000.0	-1000.0	-0.015	-1000.0
PDGFR-alpha signaling pathway	12.0	532.0	44.0	-0.019	0.054	1000.0	-1000.0	-0.021	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	12.0	474.0	37.0	-0.032	0.046	1000.0	-1000.0	-0.014	-1000.0
Paxillin-dependent events mediated by a4b1	12.0	442.0	36.0	-0.036	0.047	1000.0	-1000.0	-0.029	-1000.0
PDGFR-beta signaling pathway	12.0	1202.0	97.0	-0.058	0.065	1000.0	-1000.0	-0.032	-1000.0
Visual signal transduction: Rods	12.0	628.0	52.0	-0.002	0.047	1000.0	-1000.0	-0.015	-1000.0
Regulation of Androgen receptor activity	12.0	862.0	70.0	-0.088	0.036	1000.0	-1000.0	-0.038	-1000.0
Cellular roles of Anthrax toxin	11.0	452.0	39.0	-0.031	0.028	1000.0	-1000.0	-0.013	-1000.0
Nongenotropic Androgen signaling	11.0	574.0	52.0	-0.057	0.044	1000.0	-1000.0	-0.018	-1000.0
Regulation of nuclear SMAD2/3 signaling	10.0	1404.0	136.0	-0.258	0.074	1000.0	-1000.0	-0.036	-1000.0
Sphingosine 1-phosphate (S1P) pathway	10.0	296.0	28.0	-0.037	0.043	1000.0	-1000.0	-0.011	-1000.0
Presenilin action in Notch and Wnt signaling	10.0	614.0	61.0	-0.013	0.073	1000.0	-1000.0	-0.039	-1000.0
FOXA2 and FOXA3 transcription factor networks	10.0	494.0	46.0	-0.141	0.041	1000.0	-1000.0	-0.062	-1000.0
Atypical NF-kappaB pathway	10.0	328.0	31.0	-0.018	0.035	1000.0	-1000.0	-0.006	-1000.0
Canonical Wnt signaling pathway	10.0	512.0	51.0	-0.032	0.065	1000.0	-1000.0	-0.028	-1000.0
IGF1 pathway	10.0	602.0	57.0	-0.028	0.061	1000.0	-1000.0	-0.021	-1000.0
Hedgehog signaling events mediated by Gli proteins	9.0	620.0	65.0	-0.053	0.067	1000.0	-1000.0	-0.032	-1000.0
Signaling events mediated by HDAC Class III	9.0	379.0	40.0	-0.054	0.045	1000.0	-1000.0	-0.039	-1000.0
HIF-2-alpha transcription factor network	9.0	402.0	43.0	-0.106	0.108	1000.0	-1000.0	-0.042	-1000.0
TCGA08_rtk_signaling	9.0	255.0	26.0	-0.023	0.062	1000.0	-1000.0	-0.013	-1000.0
Rapid glucocorticoid signaling	9.0	182.0	20.0	-0.008	0.028	1000.0	-1000.0	-0.0	-1000.0
Coregulation of Androgen receptor activity	8.0	638.0	76.0	-0.064	0.048	1000.0	-1000.0	-0.017	-1000.0
ErbB4 signaling events	8.0	561.0	69.0	-0.066	0.064	1000.0	-1000.0	-0.016	-1000.0
Arf6 downstream pathway	8.0	361.0	43.0	-0.039	0.048	1000.0	-1000.0	-0.032	-1000.0
mTOR signaling pathway	8.0	447.0	53.0	-0.025	0.036	1000.0	-1000.0	-0.019	-1000.0
Retinoic acid receptors-mediated signaling	8.0	504.0	58.0	-0.044	0.054	1000.0	-1000.0	-0.023	-1000.0
Insulin Pathway	8.0	645.0	74.0	-0.069	0.07	1000.0	-1000.0	-0.03	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	8.0	292.0	33.0	-0.006	0.061	1000.0	-1000.0	-0.025	-1000.0
Aurora B signaling	8.0	566.0	67.0	-0.071	0.063	1000.0	-1000.0	-0.029	-1000.0
Visual signal transduction: Cones	7.0	271.0	38.0	-0.013	0.05	1000.0	-1000.0	-0.002	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	7.0	623.0	83.0	-0.029	0.054	1000.0	-1000.0	-0.014	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	7.0	951.0	125.0	-0.024	0.069	1000.0	-1000.0	-0.013	-1000.0
Regulation of Telomerase	7.0	789.0	102.0	-0.087	0.058	1000.0	-1000.0	-0.037	-1000.0
FOXM1 transcription factor network	7.0	381.0	51.0	-0.019	0.079	1000.0	-1000.0	-0.063	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	6.0	217.0	34.0	-0.041	0.072	1000.0	-1000.0	-0.029	-1000.0
PLK1 signaling events	6.0	565.0	85.0	-0.009	0.05	1000.0	-1000.0	-0.02	-1000.0
FoxO family signaling	6.0	397.0	64.0	-0.182	0.042	1000.0	-1000.0	-0.042	-1000.0
Syndecan-3-mediated signaling events	6.0	214.0	35.0	-0.0	0.073	1000.0	-1000.0	-0.013	-1000.0
p38 MAPK signaling pathway	6.0	270.0	44.0	-0.042	0.047	1000.0	-1000.0	-0.015	-1000.0
Canonical NF-kappaB pathway	5.0	206.0	39.0	-0.005	0.058	1000.0	-1000.0	-0.02	-1000.0
BARD1 signaling events	5.0	300.0	57.0	-0.055	0.058	1000.0	-1000.0	-0.039	-1000.0
VEGFR1 specific signals	5.0	307.0	56.0	-0.028	0.054	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by PRL	5.0	173.0	34.0	-0.025	0.048	1000.0	-1000.0	-0.032	-1000.0
PLK2 and PLK4 events	4.0	13.0	3.0	0.006	-1000.0	1000.0	-1000.0	-0.004	-1000.0
Insulin-mediated glucose transport	4.0	130.0	32.0	-0.021	0.05	1000.0	-1000.0	-0.012	-1000.0
Class I PI3K signaling events mediated by Akt	4.0	276.0	68.0	-0.04	0.051	1000.0	-1000.0	-0.02	-1000.0
Aurora A signaling	3.0	223.0	60.0	-0.026	0.059	1000.0	-1000.0	-0.006	-1000.0
Signaling events mediated by HDAC Class I	3.0	402.0	104.0	-0.053	0.067	1000.0	-1000.0	-0.036	-1000.0
Arf6 trafficking events	3.0	225.0	71.0	-0.041	0.053	1000.0	-1000.0	-0.035	-1000.0
Signaling events mediated by HDAC Class II	2.0	207.0	75.0	-0.03	0.071	1000.0	-1000.0	-0.02	-1000.0
Circadian rhythm pathway	2.0	49.0	22.0	-0.008	0.045	1000.0	-1000.0	-0.02	-1000.0
Aurora C signaling	2.0	18.0	7.0	0.0	0.046	1000.0	-1000.0	-0.007	-1000.0
Arf1 pathway	2.0	135.0	54.0	-0.002	0.047	1000.0	-1000.0	-0.009	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	14.0	23.0	0.005	0.057	1000.0	-1000.0	-0.011	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	12.0	27.0	-0.01	0.067	1000.0	-1000.0	-0.023	-1000.0
Alternative NF-kappaB pathway	0.0	3.0	13.0	-0.0	0.071	1000.0	-1000.0	-0.0	-1000.0
Total	2254	132299	7203	-8.05909018616	-993.233478465	131000	-131000	-3.12033316514	-131000