rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(30), CDC25A(3), CDC25B(4), CDC25C(7), CDK2(3), CHEK1(4), MYT1(14), RB1(6), TP53(103), WEE1(2), YWHAH(3) 5794957 179 127 139 14 48 41 6 34 47 3 7.03e-10 <1.00e-15 <2.96e-13 2 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(4), CCND1(1), CDK2(3), CDKN1A(1), CDKN2A(6), CFL1(1), E2F1(2), E2F2(3), MDM2(3), NXT1(2), PRB1(2), TP53(103) 2761021 131 114 94 12 38 31 3 15 43 1 6.98e-08 <1.00e-15 <2.96e-13 3 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 DNAJA3(2), HSPA1A(1), IFNG(2), IFNGR1(5), IFNGR2(1), IKBKB(7), JAK2(10), LIN7A(7), NFKB1(7), NFKBIA(1), RB1(6), RELA(3), TNF(1), TNFRSF1A(3), TNFRSF1B(1), TP53(103), USH1C(2), WT1(3) 5958723 165 118 126 26 42 40 3 35 44 1 1.84e-05 1.44e-15 2.96e-13 4 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(3), MAX(3), MYC(3), SP1(6), SP3(3), TP53(103), WT1(3) 2316024 124 111 87 11 34 29 2 18 40 1 1.64e-08 2.33e-15 3.01e-13 5 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(4), ATM(30), BRCA1(14), CDKN1A(1), CHEK1(4), CHEK2(7), JUN(3), MAPK8(5), MDM2(3), MRE11A(2), NFKB1(7), NFKBIA(1), RAD50(9), RAD51(1), RBBP8(6), RELA(3), TP53(103), TP73(2) 9791154 205 137 167 22 51 47 8 44 52 3 7.83e-09 3.22e-15 3.01e-13 6 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 DNAJC3(3), EIF2S1(2), EIF2S2(3), MAP3K14(3), NFKB1(7), NFKBIA(1), RELA(3), TP53(103) 3207445 125 106 88 7 34 29 2 20 39 1 3.56e-09 3.33e-15 3.01e-13 7 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(18), AKT1(3), ATM(30), BAX(1), CDKN1A(1), CPB2(6), CSNK1A1(3), CSNK1D(2), FHL2(2), HIC1(5), HIF1A(5), HSPA1A(1), IGFBP3(5), MAPK8(5), MDM2(3), NFKBIB(5), NQO1(2), TP53(103) 6815341 200 134 162 20 56 47 6 33 55 3 1.20e-10 3.44e-15 3.01e-13 8 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(30), ATR(12), CDC25C(7), CHEK1(4), CHEK2(7), TP53(103), YWHAH(3) 5264371 166 128 128 15 45 34 5 32 47 3 5.92e-07 4.00e-15 3.01e-13 9 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(3), APAF1(5), ATM(30), BAD(3), BAX(1), BCL2(2), BID(2), CASP3(2), CASP6(1), CASP7(2), CASP9(2), EIF2S1(2), PRKCA(3), PTK2(10), PXN(3), STAT1(7), TLN1(14), TP53(103) 8999666 195 131 156 21 57 46 11 30 48 3 1.21e-09 4.88e-15 3.01e-13 10 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(5), ATM(30), BAX(1), BCL2(2), CCND1(1), CCNE1(3), CDK2(3), CDKN1A(1), E2F1(2), MDM2(3), PCNA(2), RB1(6), TIMP3(3), TP53(103) 5961338 165 128 126 18 44 40 5 30 43 3 1.43e-07 4.88e-15 3.01e-13 11 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(26), DAXX(9), PAX3(7), PML(7), RARA(2), RB1(6), SIRT1(4), SP100(10), TNF(1), TNFRSF1A(3), TNFRSF1B(1), TP53(103) 6230239 179 122 141 25 56 43 4 28 47 1 1.84e-07 5.77e-15 3.23e-13 12 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(4), CDKN2A(6), E2F1(2), MDM2(3), MYC(3), PIK3CA(62), PIK3R1(8), POLR1A(12), POLR1B(4), POLR1C(2), POLR1D(1), RB1(6), TBX2(3), TP53(103), TWIST1(1) 6653717 220 147 151 31 56 78 6 30 49 1 3.78e-09 6.77e-15 3.48e-13 13 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(3), BAD(3), CASP9(2), GH1(1), GHR(6), NFKB1(7), NFKBIA(1), PDPK1(2), PIK3CA(62), PIK3R1(8), PPP2CA(3), RELA(3), YWHAH(3) 4627113 104 66 73 9 18 55 6 17 8 0 4.64e-08 5.47e-09 2.59e-07 14 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(3), GRB2(4), NTRK1(6), PIK3CA(62), PIK3R1(8), PLCG1(16), PRKCA(3), SHC1(3), SOS1(6) 5116804 111 69 78 10 26 57 5 16 7 0 2.31e-08 6.48e-05 0.00285 15 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(3), CAT(4), GH1(1), GHR(6), IGF1(4), IGF1R(15), PIK3CA(62), PIK3R1(8), SHC1(3), SOD2(1) 4368739 107 66 76 13 18 57 5 19 8 0 1.36e-06 0.000330 0.0135 16 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(7), AKT1(3), ANXA1(2), CALM1(1), CALM2(3), GNAS(20), GNGT1(3), NFKB1(7), NOS3(5), NPPA(1), NR3C1(5), PIK3CA(62), PIK3R1(8), RELA(3), SYT1(3) 5870000 133 81 101 17 35 59 3 25 11 0 1.75e-06 0.00133 0.0514 17 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(8) 238419 8 8 8 0 3 1 1 1 2 0 0.0857 0.00194 0.0666 18 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(3), BAD(3), CASP9(2), CDC42(1), ELK1(3), MAP2K1(5), MAPK3(1), NFKB1(7), PIK3CA(62), PIK3R1(8), RAF1(7), RALBP1(5), RALGDS(10), RELA(3), RHOA(14) 6260663 134 80 96 19 30 64 5 26 9 0 8.65e-07 0.00195 0.0666 19 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD3E(2), CD80(1), CD86(2), CTLA4(3), GRB2(4), HLA-DRA(6), ICOS(1), ITK(5), LCK(3), PIK3CA(62), PIK3R1(8), PTPN11(5) 4212869 102 68 71 14 21 53 5 17 6 0 2.03e-05 0.00838 0.272 20 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(8), HLA-A(6), IL18(1), ITGB1(6), KLRC1(3), KLRC2(2), KLRC3(4), KLRD1(4), LAT(2), MAP2K1(5), MAPK3(1), PAK1(5), PIK3CA(62), PIK3R1(8), PTK2B(10), PTPN6(3), SYK(6), VAV1(6) 6122183 142 82 109 22 27 66 4 29 15 1 6.24e-06 0.0161 0.497 21 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(3), CREB1(3), GRB2(4), MAPK1(2), MAPK3(1), MAPK7(7), MEF2B(4), MEF2C(3), MEF2D(6), NTRK1(6), PIK3CA(62), PIK3R1(8), PLCG1(16), RPS6KA1(6), SHC1(3) 6210104 134 73 100 17 35 64 7 18 10 0 6.24e-08 0.0200 0.586 22 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(3), PIK3CA(62), PIK3R1(8), PLCB1(13), PLCG1(16), PRKCA(3), VAV1(6) 4221152 111 68 77 17 27 55 4 15 10 0 3.58e-05 0.0214 0.599 23 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(7), ELK1(3), FOS(1), GRB2(4), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(5), NGFR(4), PIK3CA(62), PIK3R1(8), PLCG1(16), RAF1(7), SHC1(3), SOS1(6) 6275037 135 75 99 19 33 61 5 27 9 0 1.44e-06 0.0448 1.000 24 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(30), ATR(12), BRCA1(14), BRCA2(27), CHEK1(4), CHEK2(7), FANCA(5), FANCC(4), FANCD2(10), FANCE(2), FANCG(3), HUS1(2), MRE11A(2), RAD1(2), RAD17(4), RAD50(9), RAD51(1), RAD9A(2), TP53(103) 14509139 243 139 205 33 58 63 8 56 55 3 2.28e-07 0.0581 1.000 25 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(3), BCAR1(4), GRB2(4), ILK(3), ITGB1(6), MAPK1(2), MAPK3(1), PDPK1(2), PIK3CA(62), PIK3R1(8), PTEN(18), PTK2(10), SHC1(3), SOS1(6) 6318779 132 71 98 16 24 60 7 23 18 0 4.43e-07 0.0586 1.000 26 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(5), BAK1(3), BAX(1), BCL2(2), BID(2), BIRC2(3), BIRC3(3), CASP2(3), CASP3(2), CASP6(1), CASP7(2), CASP8(8), CASP9(2), FAS(3), FASLG(2), GZMB(2), JUN(3), MAP2K4(7), MAP3K1(9), MAP3K14(3), MAPK10(5), MCL1(1), MDM2(3), MYC(3), NFKB1(7), NFKBIA(1), PARP1(7), PRF1(1), RELA(3), RIPK1(1), TNF(1), TNFRSF1A(3), TNFRSF1B(1), TNFSF10(3), TP53(103), TRADD(2), TRAF1(3), TRAF2(2) 12255704 216 138 176 42 62 49 5 44 55 1 1.87e-05 0.0806 1.000 27 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(4), ATM(30), ATR(12), CCNA1(7), CCND1(1), CCNE1(3), CDC25A(3), CDK2(3), CDK6(4), CDKN1A(1), CDKN2A(6), E2F1(2), GSK3B(4), HDAC1(3), RB1(6), SKP2(5), TFDP1(3), TGFB1(3), TGFB2(6), TGFB3(5), TP53(103) 9930956 214 139 175 38 57 52 6 44 52 3 4.77e-05 0.116 1.000 28 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(7), ELK1(3), FOS(1), GRB2(4), INSR(12), IRS1(15), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(5), PIK3CA(62), PIK3R1(8), PTPN11(5), RAF1(7), RASA1(11), SHC1(3), SLC2A4(4), SOS1(6), SRF(1) 8363380 163 85 129 29 39 70 5 27 22 0 5.95e-06 0.171 1.000 29 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(3), BAD(3), GRB2(4), IGF1R(15), IRS1(15), MAP2K1(5), MAPK1(2), MAPK3(1), PIK3CA(62), PIK3R1(8), RAF1(7), SHC1(3), SOS1(6), YWHAH(3) 6236996 137 77 104 25 32 66 4 23 12 0 5.27e-05 0.185 1.000 30 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(1), DCN(5), FMOD(8), KERA(1), LUM(5) 1194047 20 19 20 4 10 4 1 5 0 0 0.132 0.301 1.000 31 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(3), CREB1(3), MAP2K1(5), MAP2K2(2), MAP2K3(7), MAP2K6(1), MAP3K1(9), MAPK1(2), MAPK14(1), MAPK3(1), NFKB1(7), PIK3CA(62), PIK3R1(8), RB1(6), RELA(3), SP1(6) 6374571 126 74 91 20 22 65 5 20 14 0 1.63e-05 0.341 1.000 32 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(3), EIF2B5(6), EIF2S1(2), EIF2S2(3), EIF4E(2), EIF4EBP1(2), GSK3B(4), IGF1(4), IGF1R(15), INPPL1(14), PDPK1(2), PIK3CA(62), PIK3R1(8), PPP2CA(3), PTEN(18), RPS6(1), RPS6KB1(4) 6455542 153 78 118 25 33 64 5 29 22 0 3.46e-05 0.412 1.000 33 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(3), CCND1(1), CCNE1(3), CDK2(3), CDK6(4), CDKN1A(1), E2F1(2), MAPK1(2), MAPK3(1), NFKB1(7), NFKBIA(1), PAK1(5), PIK3CA(62), PIK3R1(8), RAF1(7), RB1(6), RELA(3), TFDP1(3) 6643398 122 70 89 19 23 62 5 22 10 0 1.72e-05 0.420 1.000 34 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(1), CCL5(1), CCR3(6), HLA-DRA(6), IL3(1) 999988 15 14 15 3 8 5 0 2 0 0 0.131 0.420 1.000 35 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(4), CRK(1), CXCR4(1), GNAI1(1), GNAQ(3), GNGT1(3), MAP2K1(5), MAPK1(2), MAPK3(1), NFKB1(7), PIK3C2G(7), PIK3CA(62), PIK3R1(8), PLCG1(16), PRKCA(3), PTK2(10), PTK2B(10), PXN(3), RAF1(7), RELA(3) 9055589 157 81 122 21 40 63 7 29 18 0 6.18e-08 0.456 1.000 36 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(3), BAD(3), CHRNB1(1), CHRNG(4), MUSK(7), PIK3CA(62), PIK3R1(8), PTK2(10), PTK2B(10), RAPSN(2), SRC(2), TERT(3), YWHAH(3) 5357618 118 69 87 23 28 53 8 19 10 0 0.000255 0.489 1.000 37 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(7), FOS(1), GRB2(4), JAK2(10), JUN(3), MAP2K1(5), MAPK3(1), PIK3CA(62), PIK3R1(8), PLCG1(16), PRKCA(3), RAF1(7), RASA1(11), SHC1(3), SOS1(6), STAT1(7), STAT3(6), STAT5A(4), STAT5B(6), THPO(4) 9852632 174 83 138 25 38 73 8 37 18 0 3.28e-07 0.497 1.000 38 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(1), GALT(1), TGDS(3), UGDH(5), UXS1(3) 1268853 13 12 13 1 4 5 1 2 1 0 0.0486 0.631 1.000 39 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(2), FOSB(3), GRIA2(17), JUND(1), PPP1R1B(1) 1225092 24 20 24 5 6 9 1 6 2 0 0.126 0.655 1.000 40 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(3), AKT2(6), AKT3(6), CDKN1A(1), ELK1(3), GRB2(4), MAP2K1(5), MAP2K2(2), NGFR(4), NTRK1(6), PIK3CA(62), PIK3CD(10), SHC1(3), SOS1(6) 5286729 121 72 87 25 35 56 4 25 1 0 0.000435 0.681 1.000 41 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(3), AKT2(6), AKT3(6), BPNT1(1), GRB2(4), ILK(3), MAPK1(2), MAPK3(1), PDK1(2), PIK3CA(62), PIK3CD(10), PTEN(18), PTK2B(10), RBL2(4), SHC1(3), SOS1(6) 6704492 141 74 107 24 40 58 3 28 12 0 0.000111 0.720 1.000 42 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(4), TPI1(1) 539342 5 5 5 1 2 2 1 0 0 0 0.358 0.724 1.000 43 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(4), IL8(1), SLPI(1) 563163 6 5 6 2 3 2 0 1 0 0 0.495 0.762 1.000 44 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(3), GSTZ1(3), HGD(3) 730546 9 8 9 3 4 2 0 3 0 0 0.492 0.765 1.000 45 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(2), IFNG(2), IL12A(2), IL12B(1), IL18(1) 980615 8 8 8 2 0 3 1 4 0 0 0.559 0.770 1.000 46 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(2) 375013 2 2 2 1 0 1 1 0 0 0 0.822 0.785 1.000 47 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(3), APC(34), AXIN1(8), CCND1(1), CD14(2), CTNNB1(16), DVL1(4), FZD1(7), GJA1(9), GNAI1(1), GSK3B(4), IRAK1(5), LBP(1), LEF1(5), LY96(1), MYD88(1), NFKB1(7), PDPK1(2), PIK3CA(62), PIK3R1(8), PPP2CA(3), RELA(3), TIRAP(1), TLR4(18), TOLLIP(2), WNT1(5) 10060823 213 108 175 40 43 78 9 47 33 3 6.25e-06 0.798 1.000 48 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(3), BCL2(2), EGFR(11), IGF1R(15), MYC(3), POLR2A(15), PPP2CA(3), PRKCA(3), RB1(6), TEP1(21), TERF1(3), TERT(3), TNKS(13), TP53(103), XRCC5(4) 9258773 208 124 169 46 59 63 6 34 45 1 0.000103 0.803 1.000 49 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(3), EIF4A1(3), EIF4A2(4), EIF4E(2), EIF4EBP1(2), EIF4G1(19), EIF4G2(5), EIF4G3(7), GHR(6), IRS1(15), MAPK1(2), MAPK14(1), MAPK3(1), MKNK1(3), PABPC1(2), PDPK1(2), PIK3CA(62), PIK3R1(8), PRKCA(3), PTEN(18), RPS6KB1(4) 9246853 172 85 139 29 36 74 7 31 24 0 1.55e-05 0.821 1.000 50 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(2), ACTR3(2), ARPC1A(3), ARPC2(1), ARPC4(2), CDC42(1), PAK1(5), PDGFRA(11), PIK3CA(62), PIK3R1(8), WASL(1) 4406845 98 62 67 21 15 57 4 13 9 0 0.00434 0.831 1.000 51 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(1), GALT(1), TGDS(3), UGDH(5), UGP2(3), UXS1(3) 1614572 16 14 16 2 6 5 1 3 1 0 0.0632 0.869 1.000 52 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(8), GLS2(6), GLUD1(3), GLUD2(10) 1489756 27 20 27 6 6 8 0 12 1 0 0.205 0.878 1.000 53 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(3), BCL2(2), BCR(9), CRKL(1), FOS(1), GRB2(4), JAK2(10), JUN(3), MAP2K1(5), MAP2K4(7), MAP3K1(9), MAPK3(1), MAPK8(5), MYC(3), PIK3CA(62), PIK3R1(8), RAF1(7), SOS1(6), STAT1(7), STAT5A(4), STAT5B(6) 9228502 163 82 128 29 35 72 5 31 20 0 7.77e-06 0.883 1.000 54 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(5), AASS(6), KARS(5) 1553133 16 12 16 2 4 6 1 5 0 0 0.117 0.888 1.000 55 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH6(5), ADH7(1), ADHFE1(8) 1855447 24 19 23 5 3 7 0 10 4 0 0.212 0.889 1.000 56 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(2), CASP3(2), CASP8(8), CFL1(1) 1273104 13 12 13 3 3 4 1 4 1 0 0.380 0.891 1.000 57 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(3), ACAT2(3), OXCT1(6) 1112143 12 11 12 4 1 8 0 2 1 0 0.608 0.893 1.000 58 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(2), LIPT1(4) 502082 6 6 6 2 1 3 0 0 2 0 0.589 0.897 1.000 59 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD4(5), HLA-DRA(6) 781158 11 10 11 4 4 4 0 3 0 0 0.560 0.908 1.000 60 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(2), CALM1(1), CALM2(3), ELK1(3), FCER1A(2), FOS(1), GRB2(4), JUN(3), LYN(4), MAP2K1(5), MAP2K4(7), MAP2K7(20), MAP3K1(9), MAPK1(2), MAPK3(1), MAPK8(5), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(12), PAK2(6), PIK3CA(62), PIK3R1(8), PLA2G4A(4), PLCG1(16), PPP3CA(5), PPP3CB(6), PPP3CC(3), RAF1(7), SHC1(3), SOS1(6), SYK(6), SYT1(3), VAV1(6) 14126172 254 102 217 42 80 93 7 43 31 0 3.28e-09 0.910 1.000 61 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(3), SUCLA2(4) 692992 7 7 7 2 3 0 0 2 2 0 0.639 0.910 1.000 62 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(30), CDC25A(3), CDC25B(4), CDC25C(7), CHEK1(4), MYT1(14), WEE1(2), YWHAH(3) 4533076 67 43 65 13 20 15 3 18 9 2 0.0393 0.929 1.000 63 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(1), CCR3(6), CD4(5), HLA-DRA(6), IL1B(2), IL4(1), IL5RA(4) 1755840 25 18 25 7 9 7 0 6 3 0 0.273 0.932 1.000 64 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(2), SRP19(7), SRP54(4), SRP68(2), SRP72(7), SRP9(1), SRPR(8) 2476389 31 24 31 5 11 10 1 7 2 0 0.0557 0.960 1.000 65 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(7), ELK1(3), FOS(1), GRB2(4), IGF1(4), IGF1R(15), IRS1(15), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(5), PIK3CA(62), PIK3R1(8), PTPN11(5), RAF1(7), RASA1(11), SHC1(3), SOS1(6), SRF(1) 8143278 166 82 132 30 38 70 5 34 19 0 1.42e-05 0.960 1.000 66 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(3), CDC25A(3), CDC25B(4), CDC25C(7), CSK(5), GRB2(4), PRKCA(3), PTPRA(7), SRC(2) 3030864 38 29 38 7 15 9 0 8 6 0 0.0314 0.965 1.000 67 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(4), ALDOB(3), ALDOC(3), TPI1(1) 1285594 11 11 11 3 3 3 1 4 0 0 0.410 0.967 1.000 68 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(3), CDC34(2), CDK2(3), CUL1(14), E2F1(2), FBXW7(20), RB1(6), TFDP1(3) 2716184 53 36 44 11 22 17 2 5 7 0 0.0151 0.969 1.000 69 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(6), SQLE(4) 1047437 10 8 10 3 4 2 1 2 1 0 0.468 0.974 1.000 70 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(2), CD34(3), CD3E(2), CD4(5), CD58(1), CD8A(4), CSF3(1), IL3(1), IL8(1), KITLG(2) 2030518 22 20 22 6 4 8 2 6 2 0 0.282 0.974 1.000 71 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(2), LPL(4), NR3C1(5), PPARG(1), RXRA(3), TNF(1) 1901245 16 16 16 5 4 2 2 7 1 0 0.458 0.977 1.000 72 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(3), CCL2(1), CSF1(1), LDLR(7), LPL(4) 1749371 16 16 16 5 7 4 0 3 2 0 0.256 0.980 1.000 73 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(3), ACAT2(3), ACYP1(1), ACYP2(3), EHHADH(6), GCDH(5), HADHA(4), SDHB(4), SDS(2) 2563914 31 22 30 6 9 14 2 2 4 0 0.0327 0.981 1.000 74 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(30), ATR(12), BRCA1(14), CCNB1(3), CDC25A(3), CDC25B(4), CDC25C(7), CDC34(2), CDKN1A(1), CDKN2D(3), CHEK1(4), CHEK2(7), EP300(19), MDM2(3), MYT1(14), PRKDC(32), RPS6KA1(6), TP53(103), WEE1(2), YWHAH(3), YWHAQ(2) 13788381 274 145 234 50 81 68 8 57 57 3 6.82e-06 0.981 1.000 75 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(1), GGT1(4), SHMT1(1), SHMT2(5) 1352041 11 11 11 8 4 0 0 2 5 0 0.919 0.985 1.000 76 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(5), CD8A(4), CSF1(1), CSF3(1), IL11(2), IL3(1), IL4(1), IL7(1), IL8(1) 1995040 17 15 17 4 5 5 1 5 1 0 0.262 0.986 1.000 77 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(3), CD3E(2), CD4(5) 1057796 10 10 10 4 1 5 1 3 0 0 0.685 0.988 1.000 78 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(9), AOC2(4), AOC3(4), CES1(8), ESD(1) 1981456 26 16 26 4 8 9 1 7 1 0 0.0444 0.990 1.000 79 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(2), CD36(2), FOS(1), FYN(8), JUN(3), MAPK14(1), THBS1(12) 2433210 29 22 29 7 8 10 1 7 3 0 0.154 0.990 1.000 80 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(5), PGLYRP2(2) 592724 7 6 7 3 3 3 0 1 0 0 0.670 0.991 1.000 81 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(2), HLCS(3), SPCS1(1), SPCS3(2) 1010636 8 7 8 3 2 1 0 5 0 0 0.697 0.991 1.000 82 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(10), APOBEC1(3), APOBEC2(1), APOBEC3B(4), APOBEC3F(1), APOBEC3G(3), APOBEC4(1) 2406087 23 17 23 4 9 6 3 4 1 0 0.0934 0.992 1.000 83 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CSF3(1), FLT3(8), IGF1(4), IL11(2), IL1A(2), IL3(1), KITLG(2), TGFB1(3), TGFB2(6), TGFB3(5) 2718178 34 25 34 9 9 9 0 11 5 0 0.295 0.994 1.000 84 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(5), ERBB4(33), NRG2(6), NRG3(13), PRKCA(3), PSEN1(2) 2956158 62 44 60 17 18 18 6 15 5 0 0.140 0.994 1.000 85 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(3), CCNH(2), CDC25A(3), CDC25B(4), CDC25C(7), MNAT1(2), SHH(4), XPO1(5) 2837526 30 17 30 5 10 9 1 7 3 0 0.0503 0.995 1.000 86 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), EHHADH(6), HADHA(4), SDS(2) 1591038 13 10 12 4 4 4 1 1 3 0 0.380 0.995 1.000 87 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(5), PLCG1(16), PRKCA(3), PTK2B(10) 2214210 34 26 32 8 19 6 1 4 4 0 0.123 0.996 1.000 88 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(2), ACADM(4), ACADS(3), ACAT1(3), HADHA(4) 1776080 16 13 15 4 6 5 0 2 3 0 0.184 0.996 1.000 89 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(3), LDLR(7), NR0B2(2), NR1H3(4), NR1H4(4), RXRA(3) 1790084 23 20 23 7 13 2 0 5 3 0 0.264 0.997 1.000 90 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(5), BAD(3), BAK1(3), BAX(1), BCL2(2), BCL2L11(1), BID(2), BIRC2(3), BIRC3(3), BIRC5(1), CASP1(2), CASP10(5), CASP2(3), CASP3(2), CASP4(4), CASP6(1), CASP7(2), CASP8(8), CASP9(2), DFFA(4), DFFB(3), FAS(3), FASLG(2), GZMB(2), HELLS(5), IKBKB(7), IRF1(4), IRF2(16), IRF4(3), IRF5(3), IRF6(3), IRF7(1), JUN(3), LTA(3), MAP2K4(7), MAP3K1(9), MAPK10(5), MDM2(3), MYC(3), NFKB1(7), NFKBIA(1), NFKBIB(5), PLEKHG5(6), PRF1(1), RELA(3), RIPK1(1), TNF(1), TNFRSF10B(2), TNFRSF1A(3), TNFRSF1B(1), TNFRSF21(5), TNFRSF25(4), TNFSF10(3), TP53(103), TP73(2), TRADD(2), TRAF1(3), TRAF2(2), TRAF3(3) 18788442 300 149 258 63 89 69 11 60 69 2 1.02e-05 0.999 1.000 91 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1), BCKDK(4), CBS(5), CTH(2), MUT(3) 1603502 15 13 14 9 4 2 1 1 7 0 0.951 0.999 1.000 92 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(2), GBA(6), GBA3(1), GGT1(4), SHMT1(1), SHMT2(5) 1798976 19 17 19 9 8 2 1 3 5 0 0.682 0.999 1.000 93 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(1), CALM2(3), CCL2(1), CCR5(3), CXCR4(1), FOS(1), GNAQ(3), JUN(3), MAPK14(1), MAPK8(5), PLCG1(16), PRKCA(3), PTK2B(10), SYT1(3) 4533592 54 38 52 10 22 16 2 10 4 0 0.00907 0.999 1.000 94 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD4(5), CD80(1), HLA-DRA(6), IL10(2), IL4(1) 1307987 15 13 15 5 6 4 0 4 1 0 0.485 0.999 1.000 95 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(8), ACO2(5), FH(2), IDH1(1), IDH2(1), MDH1(3), SDHB(4), SUCLA2(4) 2927140 28 20 27 7 14 6 0 5 3 0 0.161 0.999 1.000 96 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(6), GGPS1(1), SQLE(4) 1403200 11 8 11 4 4 3 1 2 1 0 0.585 1.000 1.000 97 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(3), B4GALT7(2), HS3ST1(2), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(3), XYLT1(8), XYLT2(7) 2111506 35 28 34 10 19 10 1 2 3 0 0.148 1.000 1.000 98 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(3), B4GALT7(2), HS3ST1(2), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(3), XYLT1(8), XYLT2(7) 2111506 35 28 34 10 19 10 1 2 3 0 0.148 1.000 1.000 99 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(9), PARK2(11), SNCA(1), SNCAIP(12), UBE2F(3), UBE2G2(1), UBE2L3(1), UBE2L6(1) 2110831 39 31 39 13 12 12 1 8 6 0 0.342 1.000 1.000 100 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(4), ARG1(2), GLS(8), GLUD1(3) 1810485 17 14 17 6 5 5 0 6 1 0 0.486 1.000 1.000 101 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(2), ASL(5), CPS1(18), GLS(8), GLUD1(3), GOT1(2) 2563580 38 31 38 10 11 9 2 14 2 0 0.247 1.000 1.000 102 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), CSF1(1), IL1B(2), MST1(3), MST1R(10), TNF(1) 2150079 18 17 18 4 8 4 0 4 2 0 0.200 1.000 1.000 103 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(4), HADH(3), HADHA(4), HADHB(4), HSD17B4(4), MECR(4), PPT1(5), PPT2(3) 2782629 31 19 30 8 6 11 3 4 7 0 0.114 1.000 1.000 104 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(2), CHRNA1(4), SNAP25(2), STX1A(2) 1071596 10 10 10 4 3 1 0 4 2 0 0.750 1.000 1.000 105 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(2), GOT2(2), TAT(4) 864014 8 8 8 4 4 3 0 1 0 0 0.720 1.000 1.000 106 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP3(2), CASP7(2), DFFA(4), DFFB(3), GZMB(2), HMGB2(2), TOP2A(3), TOP2B(8) 2937986 26 19 25 6 5 8 1 6 6 0 0.387 1.000 1.000 107 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(2), CAMP(2), DAG1(8), GNAQ(3), ITPKA(1), ITPKB(7) 1982156 23 19 23 8 10 4 0 7 2 0 0.434 1.000 1.000 108 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(1), DHRS2(1), DHRS3(2), DHRS7(3), DHRSX(5), ESCO1(4), ESCO2(4), MYST3(20), MYST4(15), NAT6(2), PNPLA3(1), SH3GLB1(1) 5433623 59 38 59 13 18 18 2 14 7 0 0.0444 1.000 1.000 109 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(7), PDXK(3), PDXP(1), PSAT1(3) 1587252 14 9 14 6 2 6 0 4 1 1 0.678 1.000 1.000 110 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 MAP3K14(3), MAPK14(1), MAPK8(5), NFKB1(7), RELA(3), TNFRSF13B(3), TNFRSF13C(2), TNFRSF17(1), TNFSF13B(3), TRAF2(2), TRAF3(3), TRAF6(5) 4763828 38 29 38 8 10 12 1 8 7 0 0.106 1.000 1.000 111 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(3), FOS(1), JUN(3), KEAP1(8), MAPK1(2), MAPK14(1), MAPK8(5), NFE2L2(1), PRKCA(3) 2896964 27 21 27 8 8 11 2 3 3 0 0.210 1.000 1.000 112 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), MIOX(3), UGDH(5) 2792705 36 27 36 11 8 13 0 10 5 0 0.324 1.000 1.000 113 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(4), CTH(2), GOT1(2), GOT2(2), LDHA(3), LDHB(4), LDHC(1), MPST(2) 2244553 20 16 20 5 7 8 1 2 2 0 0.207 1.000 1.000 114 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(2), ACADM(4), ACADS(3), ACADVL(1), ACSL1(2), ACSL3(6), ACSL4(2), CPT1A(7), CPT2(5), DCI(2), EHHADH(6), HADHA(4), SCP2(4), SLC25A20(2) 5524345 50 32 49 12 16 10 5 12 7 0 0.0748 1.000 1.000 115 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 DUSP1(2), GORASP1(3), MAP2K4(7), MAP2K7(20), MAPK1(2), MAPK10(5), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(5), MAPK8IP1(2), MAPK8IP2(3), MAPK8IP3(10), MAPK9(4), MAPKAPK5(1), NFKB1(7), NFKB2(2), NFKBIA(1), NFKBIB(5), NFKBIL1(2), NFKBIL2(7), PIK3CA(62), PIK3CD(10), PIK3R1(8), SYT1(3), TRAF2(2), TRAF3(3), TRAF6(5) 10980428 185 92 153 33 62 70 6 26 21 0 5.22e-07 1.000 1.000 116 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH5(3), ADH6(5), ADH7(1), ADHFE1(8), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3) 4348062 55 35 54 14 11 17 0 18 9 0 0.137 1.000 1.000 117 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(7), CCNE1(3), CDC34(2), CDK2(3), CUL1(14), E2F1(2), RB1(6), SKP2(5), TFDP1(3) 2810669 45 32 43 14 11 21 2 9 2 0 0.189 1.000 1.000 118 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3E(2), IFNG(2), IL2RA(2), IL4(1), TGFB1(3), TGFB2(6), TGFB3(5), TGFBR1(5), TGFBR2(11), TGFBR3(4), TOB1(1), TOB2(4) 3477389 46 37 46 13 10 14 6 10 6 0 0.291 1.000 1.000 119 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(5), AASDH(5), AASS(6), KARS(5) 2288651 21 17 21 7 5 10 1 5 0 0 0.461 1.000 1.000 120 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(4), ACAT1(3), ACAT2(3), EHHADH(6), HADHA(4), HADHB(4), SDS(2) 2746241 26 16 25 7 6 13 1 2 4 0 0.166 1.000 1.000 121 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(2), CREBBP(26), EP300(19), FYN(8), IL2RG(5), IL7(1), IL7R(5), JAK1(6), JAK3(9), LCK(3), NMI(2), PIK3CA(62), PIK3R1(8), PTK2B(10), STAT5A(4), STAT5B(6) 9170440 176 81 142 34 42 76 4 34 20 0 3.62e-05 1.000 1.000 122 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(1), EIF1(1), EIF2B1(3), EIF2B2(3), EIF2B3(5), EIF2B4(6), EIF2B5(6), EIF2S1(2), EIF2S2(3), ELAVL1(7), FLT1(13), FLT4(17), HIF1A(5), KDR(8), NOS3(5), PIK3CA(62), PIK3R1(8), PLCG1(16), PRKCA(3), PTK2(10), PXN(3), SHC1(3) 11147218 190 88 156 36 55 74 10 35 16 0 5.09e-06 1.000 1.000 123 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(4), CYP2E1(4), NR1I3(3), PTGS1(7), PTGS2(5) 1756774 23 18 23 8 8 8 1 3 3 0 0.410 1.000 1.000 124 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(5), GOT1(2), GOT2(2), TAT(4), TYR(6) 1545208 19 18 19 7 5 7 1 6 0 0 0.555 1.000 1.000 125 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYC(1), RB1(6), SP1(6), SP3(3) 2189978 16 14 15 5 2 9 0 3 2 0 0.445 1.000 1.000 126 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(3), MTMR1(4), MTMR2(3), MTMR6(5), PHPT1(2), THTPA(2), TPK1(4) 2111496 23 18 23 7 5 11 1 4 2 0 0.425 1.000 1.000 127 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), FOSL2(6), IFNAR1(5), IFNAR2(6), IFNB1(2), MAPK8(5), NFKB1(7), RELA(3), TNFRSF11A(3), TNFSF11(1), TRAF6(5) 3635783 44 33 44 12 13 15 1 10 5 0 0.164 1.000 1.000 128 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(7), ELK1(3), FOS(1), GRB2(4), JAK1(6), JUN(3), MAP2K1(5), MAP2K4(7), MAP3K1(9), MAPK3(1), MAPK8(5), PDGFA(2), PDGFRA(11), PIK3CA(62), PIK3R1(8), PLCG1(16), PRKCA(3), RAF1(7), RASA1(11), SHC1(3), SOS1(6), SRF(1), STAT1(7), STAT3(6), STAT5A(4) 11474537 198 91 160 38 49 83 7 35 24 0 6.83e-06 1.000 1.000 129 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(3), CDK2(3), CUL1(14), E2F1(2), RB1(6), RBX1(1), SKP2(5), TFDP1(3) 2826466 37 26 35 10 9 17 2 6 3 0 0.138 1.000 1.000 130 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(19), CPT1A(7), LEPR(13), PRKAA1(4), PRKAA2(5), PRKAB1(2), PRKAB2(2), PRKAG1(3), PRKAG2(3) 4760287 58 34 58 13 17 13 2 20 6 0 0.0959 1.000 1.000 131 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(26), EP300(19), ESR1(7), MAPK1(2), MAPK3(1), PELP1(5), SRC(2) 4802100 62 42 61 16 24 17 2 10 9 0 0.0609 1.000 1.000 132 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(1), CALM2(3), CDKN1A(1), GNAQ(3), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(12), PLCG1(16), PPP3CA(5), PPP3CB(6), PPP3CC(3), PRKCA(3), SP1(6), SP3(3), SYT1(3) 6870159 94 57 92 25 37 29 1 15 12 0 0.0199 1.000 1.000 133 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(3), COASY(1), DPYD(12), DPYS(7), ENPP1(5), ENPP3(4), PANK1(4), PANK2(3), PANK3(1), PANK4(1), PPCS(2), UPB1(2) 4574881 45 31 43 13 8 11 3 16 7 0 0.229 1.000 1.000 134 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(4), ACOX3(8), FADS2(4), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(1), PLA2G2D(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5) 3331593 45 35 44 12 19 7 3 15 1 0 0.183 1.000 1.000 135 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(34), CDH1(19), CREBBP(26), EP300(19), MAP2K1(5), MAP3K7(8), MAPK3(1), SKIL(2), TGFB1(3), TGFB2(6), TGFB3(5), TGFBR1(5), TGFBR2(11) 8426763 144 82 138 33 33 42 6 29 32 2 0.0175 1.000 1.000 136 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(3), ACAD9(5), ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH5(3), ADH6(5), ADH7(1), ADHFE1(8), DHRS1(1), DHRS2(1), DHRS3(2), DHRS7(3), DHRSX(5), ESCO1(4), ESCO2(4), MYST3(20), MYST4(15), NAT6(2), PNPLA3(1), SH3GLB1(1) 8198671 94 50 93 18 25 31 3 24 11 0 0.00300 1.000 1.000 137 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(1), CHST11(2), CHST12(4), CHST13(2), PAPSS1(4), PAPSS2(4), SULT1A1(2), SULT1A2(5), SULT1E1(2), SULT2A1(3), SUOX(2) 3016658 31 23 31 9 16 8 1 5 1 0 0.217 1.000 1.000 138 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(21), C5(11), C6(10), C7(2), C8A(5), C9(6) 4139342 55 34 54 16 17 16 3 14 5 0 0.239 1.000 1.000 139 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(3), CREM(3), FOS(1), JUN(3), MAPK3(1), OPRK1(6), POLR2A(15), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7) 4223145 54 38 52 16 18 21 2 9 4 0 0.0947 1.000 1.000 140 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(3), ACAT2(3), ACOT11(4), ACYP1(1), ACYP2(3), DHRS1(1), DHRS2(1), DHRS3(2), DHRS7(3), DHRSX(5), EHHADH(6), ESCO1(4), ESCO2(4), FN3K(2), GCDH(5), HADHA(4), ITGB1BP3(2), MYST3(20), MYST4(15), NAT6(2), PNPLA3(1), SH3GLB1(1), YOD1(2) 8520651 94 49 93 20 26 37 4 16 11 0 0.00388 1.000 1.000 141 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(20), GNA12(1), PRKACB(2), PRKACG(5), PRKAG1(3), PRKAR2A(2), PRKAR2B(7) 3309933 40 29 40 11 9 15 2 8 6 0 0.188 1.000 1.000 142 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM1(1), CALM2(3), CD3E(2), ELK1(3), FOS(1), FYN(8), GRB2(4), JUN(3), LAT(2), LCK(3), MAP2K1(5), MAP2K4(7), MAP3K1(9), MAPK3(1), MAPK8(5), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(12), NFKB1(7), NFKBIA(1), PIK3CA(62), PIK3R1(8), PLCG1(16), PPP3CA(5), PPP3CB(6), PPP3CC(3), PRKCA(3), PTPN7(3), RAF1(7), RASA1(11), RELA(3), SHC1(3), SOS1(6), SYT1(3), VAV1(6), ZAP70(10) 15694582 261 99 223 51 78 96 7 46 34 0 4.54e-07 1.000 1.000 143 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AIFM1(2), AKT1(3), AKT2(6), AKT3(6), APAF1(5), ATM(30), BAD(3), BAX(1), BCL2(2), BID(2), BIRC2(3), BIRC3(3), CAPN1(2), CAPN2(3), CASP10(5), CASP3(2), CASP6(1), CASP7(2), CASP8(8), CASP9(2), CSF2RB(7), DFFA(4), DFFB(3), FAS(3), FASLG(2), IKBKB(7), IL1A(2), IL1B(2), IL1R1(4), IL1RAP(5), IL3(1), IL3RA(5), IRAK1(5), IRAK2(8), IRAK3(4), IRAK4(2), MAP3K14(3), MYD88(1), NFKB1(7), NFKB2(2), NFKBIA(1), NTRK1(6), PIK3CA(62), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PPP3CA(5), PPP3CB(6), PPP3CC(3), PPP3R2(3), PRKACA(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), RELA(3), RIPK1(1), TNF(1), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10C(1), TNFRSF10D(3), TNFRSF1A(3), TNFSF10(3), TP53(103), TRADD(2), TRAF2(2) 27369421 463 166 387 96 143 132 14 89 82 3 1.24e-08 1.000 1.000 144 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(1), GSR(4), GSS(3), IL8(1), NFKB1(7), NOX1(4), RELA(3), TNF(1), XDH(11) 3266058 35 25 35 10 7 14 2 9 3 0 0.212 1.000 1.000 145 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(8), CD3E(2), GZMB(2), HLA-A(6), ICAM1(1), ITGAL(11), ITGB2(5), PRF1(1) 2867113 36 28 36 12 10 9 2 8 6 1 0.409 1.000 1.000 146 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(3), BCAT2(5), COASY(1), DPYD(12), DPYS(7), ENPP1(5), ENPP3(4), ILVBL(3), PANK1(4), PANK2(3), PANK3(1), PANK4(1), PPCDC(1), PPCS(2), UPB1(2), VNN1(1) 5682071 55 35 53 15 15 13 3 17 7 0 0.130 1.000 1.000 147 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(4), ALAS1(2), ALAS2(9), CPOX(2), FECH(6), HMBS(2), PPOX(2), UROD(1), UROS(3) 2493490 31 26 31 9 8 8 2 10 3 0 0.388 1.000 1.000 148 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(12), GABRA2(5), GABRA3(7), GABRA4(7), GABRA5(5), GABRA6(8), GPX1(1), PRKCE(8) 2583328 53 36 53 21 13 11 7 19 3 0 0.647 1.000 1.000 149 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(6), F13A1(10), F2(5), F2R(2), FGA(7), FGB(2), FGG(2), PLAT(4), PLAU(2), PLG(11), SERPINB2(6), SERPINE1(3) 4408870 60 40 59 19 19 12 5 18 6 0 0.237 1.000 1.000 150 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(3), GRB2(4), HBXIP(1), PTK2B(10), SHC1(3), SOS1(6), SRC(2) 2903718 29 21 29 9 9 8 0 9 3 0 0.418 1.000 1.000 151 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(6), ALPL(4), ALPP(7), ALPPL2(6), FPGS(1), GGH(3), SPR(2) 2134215 29 23 28 12 19 3 0 5 2 0 0.411 1.000 1.000 152 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(1), B3GNT1(3), FUT1(2), FUT9(5), GCNT2(1), ST8SIA1(4) 2004983 16 15 16 7 6 3 0 7 0 0 0.656 1.000 1.000 153 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(5), BAK1(3), BAX(1), BCL2(2), BID(2), BIRC2(3), BIRC3(3), CASP3(2), CASP6(1), CASP7(2), CASP8(8), CASP9(2), DFFA(4), DFFB(3), DIABLO(1) 4414896 42 30 41 10 13 11 1 13 4 0 0.208 1.000 1.000 154 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(3), ATF2(1), CDC42(1), DLD(3), DUSP10(6), DUSP8(1), GAB1(2), GCK(4), IL1R1(4), JUN(3), MAP2K4(7), MAP2K5(1), MAP2K7(20), MAP3K1(9), MAP3K10(8), MAP3K11(7), MAP3K12(9), MAP3K13(7), MAP3K2(3), MAP3K3(4), MAP3K4(15), MAP3K5(4), MAP3K7(8), MAP3K9(3), MAPK10(5), MAPK7(7), MAPK8(5), MAPK9(4), MYEF2(9), NFATC3(4), NR2C2(2), PAPPA(19), SHC1(3), TP53(103), TRAF6(5), ZAK(7) 16513595 306 138 266 69 91 80 14 51 69 1 6.89e-05 1.000 1.000 155 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(1), CR1(23), CR2(8), FCGR2B(3), HLA-DRA(6), ICAM1(1), ITGAL(11), ITGB2(5), PTPRC(15) 4996443 73 46 69 23 21 26 0 19 7 0 0.240 1.000 1.000 156 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(4), CYB5R3(1), GCK(4), GFPT1(3), GNE(5), GNPDA1(3), GNPDA2(2), HEXA(2), HEXB(2), HK1(11), HK2(8), HK3(5), PGM3(10), RENBP(2), UAP1(3) 5564768 65 43 65 17 21 21 3 16 4 0 0.0676 1.000 1.000 157 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA10(1), NDUFA8(5), NDUFB2(1), NDUFB4(1), NDUFB5(1), NDUFB6(1), NDUFB7(1), NDUFS1(6), NDUFS2(2), NDUFV1(2) 2273199 22 19 22 7 5 7 1 7 2 0 0.546 1.000 1.000 158 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(3), EIF4A1(3), EIF4A2(4), EIF4B(4), EIF4E(2), EIF4EBP1(2), EIF4G1(19), EIF4G2(5), EIF4G3(7), FKBP1A(2), MKNK1(3), PDPK1(2), PIK3CA(62), PIK3R1(8), PPP2CA(3), PTEN(18), RPS6(1), RPS6KB1(4), TSC1(3), TSC2(7) 9067916 162 79 129 32 37 70 6 30 19 0 0.000344 1.000 1.000 159 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(1), PAPSS1(4), PAPSS2(4), SULT1A2(5), SULT1E1(2), SULT2A1(3), SUOX(2) 2009771 21 17 21 7 10 7 0 3 1 0 0.526 1.000 1.000 160 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(4), CYP2A13(7), CYP2A6(5), CYP2A7(5), NAT1(1), NAT2(4), XDH(11) 2622443 37 29 37 12 9 15 1 12 0 0 0.290 1.000 1.000 161 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(4), ALAS1(2), ALAS2(9), CPO(3), FECH(6), GATA1(3), HBB(1), HMBS(2), UROD(1), UROS(3) 2579949 34 28 34 10 9 7 3 12 3 0 0.424 1.000 1.000 162 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(3), AP2A1(4), AP2M1(5), ARF1(4), BAD(3), BTK(2), EEA1(9), GRASP(1), GSK3A(2), GSK3B(4), LYN(4), PDPK1(2), PFKL(4), PFKM(3), PFKP(8), PLCG1(16), PRKCE(8), RAB5A(2), RPS6KB1(4), VAV2(11) 8194563 99 48 97 26 35 30 6 18 9 1 0.0276 1.000 1.000 163 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(3), AGPAT2(1), AGPAT3(2), AGPAT4(5), AGPAT6(3), AGPS(1), CHPT1(3), ENPP2(5), ENPP6(5), PAFAH1B1(5), PAFAH1B2(2), PAFAH1B3(1), PAFAH2(1), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(1), PLA2G2D(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), PLD1(13), PLD2(13), PPAP2A(1), PPAP2C(4) 7613397 97 45 97 18 31 33 4 19 10 0 0.000826 1.000 1.000 164 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(5), ARHGAP5(11), ARHGDIB(1), CASP1(2), CASP10(5), CASP3(2), CASP8(8), CASP9(2), GZMB(2), JUN(3), PRF1(1) 4235643 42 33 41 13 9 9 4 13 6 1 0.468 1.000 1.000 165 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(3), ENO1(2), GPI(5), HK1(11), PFKL(4), PGK1(4), PKLR(5), TPI1(1) 3037998 35 28 35 12 11 11 2 10 1 0 0.330 1.000 1.000 166 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(2), FOS(1), JUN(3), MAP2K1(5), MAPK1(2), MAPK3(1), MYC(3), NFKB1(7), NFKBIA(1), PLCB1(13), PRKCA(3), RAF1(7), RELA(3), TNF(1) 5102124 52 36 49 16 16 13 1 18 4 0 0.252 1.000 1.000 167 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(3), F13B(13), HSD17B1(4), HSD17B2(2), HSD17B3(1), HSD17B4(4), HSD17B7(2), HSD3B1(1), HSD3B2(3) 2662456 33 29 33 12 6 10 2 11 4 0 0.413 1.000 1.000 168 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(7), EGF(8), EGFR(11), ELK1(3), FOS(1), GRB2(4), JAK1(6), JUN(3), MAP2K1(5), MAP2K4(7), MAP3K1(9), MAPK3(1), MAPK8(5), PIK3CA(62), PIK3R1(8), PLCG1(16), PRKCA(3), RAF1(7), RASA1(11), SHC1(3), SOS1(6), SRF(1), STAT1(7), STAT3(6), STAT5A(4) 12319861 204 92 166 44 53 81 7 38 25 0 0.000102 1.000 1.000 169 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(11), DIAPH1(7), FYN(8), GSN(9), ITGA1(7), ITGB1(6), MAP2K1(5), MAPK1(2), MAPK3(1), MYL2(6), MYLK(15), PIK3CA(62), PIK3R1(8), PTK2(10), PXN(3), RAF1(7), ROCK1(9), SHC1(3), SRC(2), TLN1(14) 12270868 195 87 160 38 45 76 12 41 19 2 2.74e-05 1.000 1.000 170 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(2), GPD2(6), NDUFA1(1), SDHA(6), SDHB(4), SDHC(1), UQCRC1(2) 2174679 22 18 22 9 9 6 2 3 2 0 0.556 1.000 1.000 171 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(16), AKT1(3), BAD(3), BAX(1), BCL2(2), CSF2RB(7), IGF1(4), IGF1R(15), IL3(1), IL3RA(5), KIT(12), KITLG(2), PIK3CA(62), PIK3R1(8), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), YWHAH(3) 7202052 166 83 134 44 44 77 5 29 11 0 0.00139 1.000 1.000 172 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(3), FDPS(6), HMGCR(6), LSS(4), MVD(2), MVK(8), NQO1(2), NQO2(3), SC5DL(4), SQLE(4) 3613235 42 26 40 13 13 10 1 12 6 0 0.328 1.000 1.000 173 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(1), GHR(6), GRB2(4), INSR(12), IRS1(15), JAK2(10), MAP2K1(5), MAPK1(2), MAPK3(1), PIK3CA(62), PIK3R1(8), PLCG1(16), PRKCA(3), PTPN6(3), RAF1(7), RPS6KA1(6), SHC1(3), SLC2A4(4), SOCS1(1), SOS1(6), SRF(1), STAT5A(4), STAT5B(6) 10859818 186 85 151 39 50 82 5 30 19 0 4.51e-05 1.000 1.000 174 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(34), ASAH1(2), CAMP(2), CASP3(2), CERK(5), CREB1(3), CREB3(4), CREB5(4), CXCL2(2), DAG1(8), EPHB2(8), FOS(1), GNAQ(3), ITPKA(1), ITPKB(7), JUN(3), MAP2K4(7), MAP2K7(20), MAPK1(2), MAPK10(5), MAPK8(5), MAPK8IP1(2), MAPK8IP2(3), MAPK8IP3(10), MAPK9(4) 9330571 147 72 144 33 47 37 3 29 29 2 0.00227 1.000 1.000 175 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(10), EIF2AK4(7), EIF2B5(6), EIF2S1(2), EIF2S2(3), EIF5(5), GSK3B(4), PPP1CA(2) 3790495 39 30 39 11 8 13 1 13 4 0 0.317 1.000 1.000 176 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(3), CDC25B(4), CDKN1A(1), CHEK1(4), NEK1(2), WEE1(2) 2266134 16 14 16 6 5 6 0 4 1 0 0.711 1.000 1.000 177 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(3), NFKB1(7), NFKBIA(1), PLCB1(13), PRKCA(3), RELA(3) 2704713 30 23 29 10 9 7 0 9 5 0 0.483 1.000 1.000 178 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(2), BFAR(2), BRAF(9), CAMP(2), CREB1(3), CREB3(4), CREB5(4), MAPK1(2), RAF1(7), SNX13(6), SRC(2), TERF2IP(4) 3679905 47 33 45 14 15 12 0 13 7 0 0.321 1.000 1.000 179 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(3), ACAT2(3), BDH1(4), HMGCS1(1), HMGCS2(3), OXCT1(6), OXCT2(1) 2364535 21 18 21 9 5 8 1 6 1 0 0.721 1.000 1.000 180 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(19), ACACB(22), FASN(14), MCAT(2), OXSM(3) 5146327 60 36 59 17 17 15 2 17 9 0 0.156 1.000 1.000 181 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(1), CDKN1A(1), EPOR(2), GRIN1(4), HIF1A(5), JAK2(10), NFKB1(7), NFKBIA(1), RELA(3), SOD2(1) 4148563 35 23 35 11 6 12 1 8 8 0 0.421 1.000 1.000 182 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(18), ABCB11(8), ABCB4(17), ABCC1(9), ABCC3(8) 4713923 60 40 60 19 16 19 3 12 10 0 0.196 1.000 1.000 183 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(2), PSMA2(1), PSMA3(2), PSMA4(4), PSMA6(4), PSMA7(4), PSMB1(2), PSMB10(1), PSMB2(2), PSMB3(2), PSMB4(3), PSMB5(1), PSMB6(1), PSMB8(3), PSMB9(1) 2874614 33 22 32 11 12 11 2 5 3 0 0.361 1.000 1.000 184 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(3), ALOX15(3), ALOX15B(3), ALOX5(6), ALOX5AP(3), DPEP1(1), GGT1(4), LTA4H(4), PLA2G2A(1), PLA2G6(5), PTGDS(1), PTGIS(5), PTGS1(7), PTGS2(5), TBXAS1(2) 4926750 53 38 53 15 20 12 4 10 7 0 0.106 1.000 1.000 185 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(6), DHCR7(3), FDPS(6), HMGCR(6), HMGCS1(1), LSS(4), MVD(2), MVK(8), NSDHL(3), SC4MOL(4), SC5DL(4), SQLE(4) 4313277 51 31 49 16 14 11 2 16 8 0 0.396 1.000 1.000 186 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(4), CARS2(5), CDO1(1), CTH(2), GOT1(2), GOT2(2), LDHA(3), LDHAL6B(4), LDHB(4), LDHC(1), MPST(2), SDS(2), SULT1B1(3), SULT1C2(1), SULT1C4(2), SULT4A1(1) 4110623 39 27 39 12 15 14 1 6 3 0 0.214 1.000 1.000 187 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(7), ELK1(3), EPOR(2), FOS(1), GRB2(4), JAK2(10), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(5), PLCG1(16), PTPN6(3), RAF1(7), SHC1(3), SOS1(6), STAT5A(4), STAT5B(6) 7054795 86 46 82 23 25 29 2 23 7 0 0.0911 1.000 1.000 188 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(13), AP2A1(4), AP2M1(5), BIN1(2), CALM1(1), CALM2(3), DNM1(5), EPN1(1), PICALM(2), PPP3CA(5), PPP3CB(6), PPP3CC(3), SYNJ1(7), SYNJ2(9), SYT1(3) 7108672 69 46 68 19 21 15 3 21 9 0 0.118 1.000 1.000 189 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(5), BAD(3), BAK1(3), BAX(1), BCL10(1), BCL2(2), BCL2L11(1), BID(2), CASP8AP2(7), CASP9(2), CES1(8) 3588047 35 20 35 12 13 12 1 7 2 0 0.398 1.000 1.000 190 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(2), PSMA2(1), PSMA3(2), PSMA4(4), PSMA6(4), PSMA7(4), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(3), PSMB5(1), PSMB6(1), PSMC2(5), PSMC3(6), PSMD1(2), PSMD11(2), PSMD12(2), PSMD13(2), PSMD2(12), PSMD6(1) 5259356 60 33 59 15 21 20 2 13 4 0 0.102 1.000 1.000 191 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG5(1), ATG7(4), BECN1(6), GABARAPL1(4), IFNA1(1), IFNA10(5), IFNA13(1), IFNA16(2), IFNA17(4), IFNA2(1), IFNA21(1), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(4), IFNA8(1), IFNG(2), PIK3C3(10), PIK3R4(10), PRKAA1(4), PRKAA2(5), ULK1(11), ULK2(5) 6919459 88 47 86 25 18 22 8 29 11 0 0.176 1.000 1.000 192 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(3), B3GAT2(2), B3GAT3(3), B4GALT7(2), CHPF(2), CHST11(2), CHST12(4), CHST13(2), CHST14(2), CHST3(3), CHST7(7), CHSY1(4), DSE(5), UST(7), XYLT1(8), XYLT2(7) 4526816 63 39 63 18 33 19 1 8 2 0 0.0633 1.000 1.000 193 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(2), CDK5R1(1), DAB1(8), FYN(8), LRP8(3), RELN(37), VLDLR(5) 4608160 64 38 64 22 17 26 2 12 7 0 0.224 1.000 1.000 194 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(9), ACY1(2), ADC(1), AGMAT(1), ALDH18A1(6), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), AMD1(3), AOC2(4), AOC3(4), ARG1(2), ASL(5), ASS1(7), CPS1(18), GATM(3), MAOA(1), MAOB(3), NAGS(1), ODC1(3), OTC(2), SAT1(1), SMS(3), SRM(1) 9671378 108 49 108 26 30 38 5 27 8 0 0.0116 1.000 1.000 195 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(3), CAT(4), EPX(6), LPO(7), MPO(6), MTHFR(6), PRDX6(1), SHMT1(1), SHMT2(5), TPO(15) 3800101 54 40 54 17 21 10 3 12 8 0 0.315 1.000 1.000 196 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(6), DCXR(1), GUSB(8), RPE(4), UCHL1(1), UCHL3(3), UGDH(5), UGT1A1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A5(8), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2B15(2), UGT2B4(3) 5742609 52 31 52 15 15 19 1 11 6 0 0.139 1.000 1.000 197 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), LDLR(7), MBTPS1(8), MBTPS2(3), SCAP(9), SREBF1(8), SREBF2(5) 3866039 41 28 41 13 16 14 1 8 2 0 0.193 1.000 1.000 198 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), ENO2(3), ENO3(4), FARS2(6), GOT1(2), GOT2(2), PAH(4), TAT(4), YARS(3) 2730565 30 23 30 10 11 10 0 7 2 0 0.413 1.000 1.000 199 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(11), KHK(2), LCT(15), MPI(3), PGM1(2), PYGL(6), PYGM(9), TPI1(1), TREH(3) 4393626 52 38 52 17 23 17 1 6 5 0 0.228 1.000 1.000 200 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(5), CSF1(1), CSF3(1), HLA-DRA(6), IFNA1(1), IFNB1(2), IFNG(2), IL10(2), IL11(2), IL12A(2), IL12B(1), IL13(1), IL1A(2), IL3(1), IL4(1), IL7(1), IL8(1), LTA(3), PDGFA(2), TGFB1(3), TGFB2(6), TGFB3(5), TNF(1) 4366098 52 38 52 18 15 16 2 15 4 0 0.411 1.000 1.000 201 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(4), ACO1(8), ACO2(5), ACSS1(9), ACSS2(6), FH(2), IDH1(1), IDH2(1), MDH1(3), SUCLA2(4) 4373260 43 29 42 14 19 8 3 7 6 0 0.241 1.000 1.000 202 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 64 APAF1(5), ATM(30), ATR(12), BAI1(8), BAX(1), BID(2), CASP3(2), CASP8(8), CASP9(2), CCNB1(3), CCNB2(1), CCNB3(16), CCND1(1), CCND2(3), CCND3(2), CCNE1(3), CCNE2(2), CD82(3), CDK2(3), CDK6(4), CDKN1A(1), CDKN2A(6), CHEK1(4), CHEK2(7), DDB2(1), EI24(1), FAS(3), GTSE1(3), IGF1(4), IGFBP3(5), LRDD(6), MDM2(3), MDM4(4), PERP(3), PPM1D(7), PTEN(18), RCHY1(1), RFWD2(5), RPRM(3), RRM2(3), RRM2B(4), SERPINB5(2), SERPINE1(3), SESN1(1), SESN2(2), SESN3(4), SIAH1(1), STEAP3(6), THBS1(12), TNFRSF10B(2), TP53(103), TP73(2), TSC2(7), ZMAT3(4) 21404558 352 159 311 84 100 92 9 75 73 3 0.000244 1.000 1.000 203 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAD(3), BAX(1), BCL2(2), CASP8(8), MAP2K1(5), MAP2K4(7), MAP3K1(9), MAPK1(2), MAPK3(1), MAPK8(5), NFKB1(7), NSMAF(7), RAF1(7), RELA(3), RIPK1(1), SMPD1(5), TNFRSF1A(3), TRADD(2), TRAF2(2) 6723990 80 47 76 25 30 19 2 15 14 0 0.192 1.000 1.000 204 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(26), EP300(19), LPL(4), NCOA1(12), NCOA2(21), PPARG(1), RXRA(3) 6067007 86 45 85 28 25 28 4 18 11 0 0.233 1.000 1.000 205 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1L(1), BNIP1(4), GOSR1(2), GOSR2(1), SEC22B(1), SNAP25(2), SNAP29(1), STX10(3), STX11(5), STX12(1), STX16(5), STX17(1), STX18(1), STX19(3), STX2(2), STX3(2), STX4(1), STX5(1), STX6(5), STX7(2), STX8(3), TSNARE1(6), USE1(4), VAMP4(1), VAMP5(1), VAMP7(4), VTI1A(1), VTI1B(3), YKT6(1) 5487041 68 37 68 19 27 19 2 13 7 0 0.143 1.000 1.000 206 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(3), ABP1(9), AOC2(4), AOC3(4), CES1(8), CES7(7), DDHD1(9), ESCO1(4), ESCO2(4), LIPA(1), MYST3(20), MYST4(15), NAT6(2), PLA1A(2), PNPLA3(1), PRDX6(1), SH3GLB1(1) 8314382 95 47 94 26 27 30 3 26 9 0 0.0858 1.000 1.000 207 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(9), ALDH1A3(5), ALDH3A1(4), ALDH3B1(3), ALDH3B2(7), AOC2(4), AOC3(4), DDC(5), EPX(6), GOT1(2), GOT2(2), HPD(1), LPO(7), MAOA(1), MAOB(3), MPO(6), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(1), TAT(4), TPO(15) 7199899 93 52 93 28 31 24 4 28 6 0 0.132 1.000 1.000 208 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(3), AVP(3), CABIN1(13), CALM1(1), CALM2(3), CAMK1(2), CAMK1G(3), HDAC5(6), IGF1(4), IGF1R(15), INSR(12), MAP2K6(1), MAPK14(1), MAPK7(7), MEF2B(4), MEF2C(3), MEF2D(6), MYOD1(4), NFATC1(11), NFATC2(14), PIK3CA(62), PIK3R1(8), PPP3CA(5), PPP3CB(6), PPP3CC(3), SYT1(3), YWHAH(3) 11391235 206 87 174 51 65 80 7 33 21 0 0.000123 1.000 1.000 209 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(5), IFNB1(2), JAK1(6), PTPRU(16), REG1A(3), STAT1(7), STAT2(4), TYK2(4) 4095015 47 32 47 15 17 15 2 10 3 0 0.262 1.000 1.000 210 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(5), IFNAR2(6), IFNB1(2), JAK1(6), STAT1(7), STAT2(4), TYK2(4) 3549994 35 23 35 12 10 11 2 9 3 0 0.388 1.000 1.000 211 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(5), CYSLTR2(1), GPR109B(3), GPR161(3), GPR171(2), GPR18(2), GPR39(6), GPR45(9), GPR65(1), GPR68(2), GPR75(4), GPR81(3) 3234234 41 32 41 16 20 8 3 8 2 0 0.379 1.000 1.000 212 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(13), CALM1(1), CALM2(3), CAPN2(3), CAPNS1(2), CAPNS2(2), EP300(19), HDAC1(3), HDAC2(2), MEF2D(6), NFATC1(11), NFATC2(14), PPP3CA(5), PPP3CB(6), PPP3CC(3), PRKCA(3), SYT1(3) 8008371 99 48 98 28 41 24 0 19 15 0 0.0517 1.000 1.000 213 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(1), ASPH(4), COPS5(2), CREB1(3), EDN1(2), EP300(19), HIF1A(5), JUN(3), LDHA(3), NOS3(5), P4HB(2) 5565792 49 32 48 15 16 13 3 10 7 0 0.236 1.000 1.000 214 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(4), POLR2A(15), POLR2B(9), POLR2C(2), POLR2E(2), POLR2F(1), POLR2G(1), POLR2I(1), POLR2K(1), POLRMT(10) 4398776 46 28 45 14 19 16 0 9 2 0 0.193 1.000 1.000 215 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(1), AKT1(3), AKT2(6), AKT3(6), BAD(3), BTK(2), CDKN2A(6), DAPP1(1), GRB2(4), GSK3A(2), GSK3B(4), IARS(9), IGFBP1(5), INPP5D(1), PDK1(2), PIK3CA(62), PPP1R13B(6), PTEN(18), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3), RPS6KB1(4), SHC1(3), SOS1(6), SOS2(11), TEC(4), YWHAB(1), YWHAE(1), YWHAG(1), YWHAH(3), YWHAQ(2), YWHAZ(2) 11837066 196 98 163 47 48 74 5 42 27 0 0.00405 1.000 1.000 216 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), IFNG(2), IFNGR1(5), JAK1(6), JAK2(10), PLA2G2A(1), PTPRU(16), REG1A(3), STAT1(7) 3765039 51 31 51 17 14 18 3 11 5 0 0.351 1.000 1.000 217 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(1), C1R(3), C1S(5), C2(2), C3(21), C5(11), C6(10), C7(2), C8A(5), C8B(11), C9(6), MASP1(3) 6841557 80 45 77 24 25 19 4 21 10 1 0.308 1.000 1.000 218 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(1), CALM2(3), CAMK1(2), CAMK1G(3), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CAMK4(6), HDAC5(6), MEF2B(4), MEF2C(3), MEF2D(6), PPARA(3), PPP3CA(5), PPP3CB(6), PPP3CC(3), SLC2A4(4), SYT1(3), YWHAH(3) 6619327 73 48 72 23 25 18 3 16 11 0 0.213 1.000 1.000 219 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(4), HK1(11), HK2(8), HK3(5), IMPA1(3), PGM1(2), PGM3(10), TGDS(3) 3361435 46 33 46 17 14 17 2 10 3 0 0.353 1.000 1.000 220 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(2), CHPT1(3), HEMK1(1), LCMT1(1), LCMT2(7), METTL6(2), PCYT1A(6), PCYT1B(5), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(4), PRMT8(3), WBSCR22(4) 4619591 47 31 47 16 14 16 1 10 6 0 0.339 1.000 1.000 221 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(9), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH3B1(3), ALDH3B2(7), ALDH9A1(3), AOC2(4), AOC3(4), ASPA(1), CNDP1(1), DDC(5), HAL(1), HARS(5), HDC(7), HNMT(2), MAOA(1), MAOB(3), PRPS1(2), PRPS2(2) 8019771 93 46 93 29 30 25 4 25 9 0 0.196 1.000 1.000 222 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(1), IFNG(2), IKBKB(7), IL4(1), JUN(3), MAP3K1(9), MAP3K5(4), MAP4K5(3), MAPK14(1), MAPK8(5), NFKB1(7), NFKBIA(1), RELA(3), TNFRSF9(6), TRAF2(2) 6356161 55 33 52 16 21 9 3 10 12 0 0.268 1.000 1.000 223 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(2), CRK(1), CRKL(1), DOCK1(15), ELK1(3), FOS(1), GAB1(2), GRB2(4), HGF(13), ITGA1(7), ITGB1(6), JUN(3), MAP2K1(5), MAP2K2(2), MAP4K1(3), MAPK1(2), MAPK3(1), MAPK8(5), MET(7), PAK1(5), PIK3CA(62), PIK3R1(8), PTEN(18), PTK2(10), PTK2B(10), PTPN11(5), PXN(3), RAF1(7), RAP1A(2), RAP1B(5), RASA1(11), SOS1(6), SRC(2), STAT3(6) 14517980 243 98 203 60 56 85 12 57 33 0 0.00126 1.000 1.000 224 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(5), BIRC2(3), BIRC3(3), CASP10(5), CASP3(2), CASP7(2), CASP8(8), CASP9(2), DFFA(4), DFFB(3), GZMB(2), PRF1(1), SCAP(9), SREBF1(8), SREBF2(5) 5939073 62 42 61 18 20 14 3 19 6 0 0.278 1.000 1.000 225 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(7), ELK1(3), FOS(1), GRB2(4), IL2RA(2), IL2RB(2), IL2RG(5), JAK1(6), JAK3(9), JUN(3), LCK(3), MAP2K1(5), MAPK3(1), MAPK8(5), RAF1(7), SHC1(3), SOS1(6), STAT5A(4), STAT5B(6), SYK(6) 7641287 88 47 84 26 22 30 1 28 7 0 0.177 1.000 1.000 226 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(8), IL13(1), IL4(1), JUNB(1), MAF(3), MAP2K3(7), MAPK14(1), NFATC1(11), NFATC2(14), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7) 3958058 69 46 69 29 31 20 2 11 5 0 0.277 1.000 1.000 227 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(7), ACTN1(6), ACTN2(22), ACTN3(2), ACTN4(6), AKT1(3), AKT2(6), AKT3(6), ARHGAP5(11), BAD(3), BCAR1(4), BCL2(2), BIRC2(3), BIRC3(3), BRAF(9), CAPN2(3), CAV1(4), CAV2(2), CAV3(2), CCND1(1), CCND2(3), CCND3(2), CDC42(1), CHAD(2), COL11A1(18), COL11A2(7), COL1A1(6), COL1A2(23), COL2A1(13), COL3A1(7), COL4A1(18), COL4A2(10), COL4A4(10), COL4A6(6), COL5A1(21), COL5A2(11), COL5A3(10), COL6A1(7), COL6A2(15), COL6A3(36), COL6A6(27), COMP(2), CRK(1), CRKL(1), CTNNB1(16), DIAPH1(7), DOCK1(15), EGF(8), EGFR(11), ELK1(3), ERBB2(12), FARP2(3), FLNA(16), FLNB(11), FLNC(22), FLT1(13), FN1(23), FYN(8), GRB2(4), GRLF1(15), GSK3B(4), HGF(13), IBSP(2), IGF1(4), IGF1R(15), ILK(3), ITGA1(7), ITGA10(5), ITGA11(7), ITGA2(5), ITGA2B(7), ITGA3(7), ITGA4(9), ITGA5(4), ITGA6(4), ITGA7(7), ITGA8(5), ITGA9(7), ITGAV(5), ITGB1(6), ITGB3(3), ITGB4(12), ITGB5(5), ITGB6(3), ITGB7(4), ITGB8(8), JUN(3), KDR(8), LAMA1(36), LAMA2(23), LAMA3(17), LAMA4(14), LAMA5(23), LAMB1(11), LAMB2(16), LAMB3(14), LAMB4(13), LAMC1(11), LAMC2(7), LAMC3(13), MAP2K1(5), MAPK1(2), MAPK10(5), MAPK3(1), MAPK8(5), MAPK9(4), MET(7), MYL2(6), MYL7(1), MYL9(2), MYLK(15), MYLK2(2), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PAK7(7), PARVA(1), PARVB(4), PARVG(3), PDGFA(2), PDGFB(5), PDGFC(5), PDGFD(5), PDGFRA(11), PDGFRB(10), PDPK1(2), PGF(1), PIK3CA(62), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PIP5K1C(8), PPP1CA(2), PPP1CB(1), PPP1CC(4), PPP1R12A(2), PRKCA(3), PRKCG(13), PTEN(18), PTK2(10), PXN(3), RAC2(2), RAC3(3), RAF1(7), RAP1A(2), RAP1B(5), RAPGEF1(9), RELN(37), RHOA(14), ROCK1(9), ROCK2(7), SHC1(3), SHC2(2), SHC3(8), SHC4(1), SOS1(6), SOS2(11), SPP1(3), SRC(2), THBS1(12), THBS2(7), THBS3(6), THBS4(10), TLN1(14), TLN2(21), TNC(17), TNN(17), TNR(18), TNXB(38), VASP(2), VAV1(6), VAV2(11), VAV3(10), VCL(1), VEGFC(8), VTN(4), VWF(19), ZYX(5) 121827729 1598 194 1534 627 546 455 58 371 165 3 0.271 1.000 1.000 228 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(12), ACVR1C(3), AKT1(3), AKT2(6), AKT3(6), ARRB1(3), ATF2(1), BDNF(5), BRAF(9), CACNA1A(16), CACNA1B(22), CACNA1C(27), CACNA1D(21), CACNA1E(30), CACNA1F(9), CACNA1G(15), CACNA1H(16), CACNA1I(16), CACNA1S(11), CACNA2D1(7), CACNA2D2(6), CACNA2D3(13), CACNA2D4(8), CACNB1(1), CACNB2(12), CACNB3(2), CACNB4(4), CACNG1(1), CACNG2(1), CACNG3(5), CACNG4(3), CACNG5(7), CACNG6(1), CACNG7(8), CACNG8(1), CASP3(2), CD14(2), CDC25B(4), CDC42(1), CRK(1), CRKL(1), DAXX(9), DDIT3(3), DUSP1(2), DUSP10(6), DUSP14(2), DUSP16(8), DUSP2(2), DUSP3(1), DUSP5(7), DUSP6(3), DUSP8(1), DUSP9(3), ECSIT(1), EGF(8), EGFR(11), ELK1(3), ELK4(1), FAS(3), FASLG(2), FGF1(2), FGF10(5), FGF11(1), FGF12(5), FGF13(7), FGF14(6), FGF17(4), FGF18(2), FGF2(2), FGF20(3), FGF21(2), FGF22(1), FGF23(1), FGF3(1), FGF5(1), FGF6(5), FGF7(2), FGF8(1), FGF9(6), FGFR1(11), FGFR2(8), FGFR3(3), FGFR4(6), FLNA(16), FLNB(11), FLNC(22), FOS(1), GNA12(1), GNG12(1), GRB2(4), IKBKB(7), IL1A(2), IL1B(2), IL1R1(4), IL1R2(5), JUN(3), JUND(1), KRAS(25), MAP2K1(5), MAP2K2(2), MAP2K3(7), MAP2K4(7), MAP2K5(1), MAP2K6(1), MAP2K7(20), MAP3K1(9), MAP3K10(8), MAP3K12(9), MAP3K13(7), MAP3K14(3), MAP3K2(3), MAP3K3(4), MAP3K4(15), MAP3K5(4), MAP3K6(5), MAP3K7(8), MAP4K1(3), MAP4K2(4), MAP4K3(3), MAP4K4(8), MAPK1(2), MAPK10(5), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(7), MAPK8(5), MAPK8IP1(2), MAPK8IP2(3), MAPK8IP3(10), MAPK9(4), MAPKAPK2(1), MAPKAPK3(4), MAPKAPK5(1), MAPT(4), MAX(3), MEF2C(3), MKNK1(3), MKNK2(1), MOS(9), MYC(3), NF1(15), NFATC2(14), NFATC4(12), NFKB1(7), NFKB2(2), NLK(6), NR4A1(4), NRAS(2), NTF3(3), NTRK1(6), NTRK2(9), PAK1(5), PAK2(6), PDGFA(2), PDGFB(5), PDGFRA(11), PDGFRB(10), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(1), PLA2G2D(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), PPM1A(3), PPM1B(8), PPP3CA(5), PPP3CB(6), PPP3CC(3), PPP3R2(3), PPP5C(6), PRKACA(3), PRKACB(2), PRKACG(5), PRKCA(3), PRKCG(13), PRKX(4), PTPN5(1), PTPN7(3), PTPRR(7), RAC2(2), RAC3(3), RAF1(7), RAP1A(2), RAP1B(5), RAPGEF2(10), RASA1(11), RASA2(4), RASGRF1(7), RASGRF2(12), RASGRP1(5), RASGRP2(6), RASGRP3(4), RASGRP4(3), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3), RPS6KA4(1), RPS6KA5(2), RPS6KA6(15), RRAS(1), RRAS2(3), SOS1(6), SOS2(11), SRF(1), STK3(4), STK4(3), STMN1(2), TAOK1(10), TAOK2(15), TAOK3(9), TGFB1(3), TGFB2(6), TGFB3(5), TGFBR1(5), TGFBR2(11), TNF(1), TNFRSF1A(3), TP53(103), TRAF2(2), TRAF6(5), ZAK(7) 93507925 1353 188 1271 421 497 372 51 249 182 2 5.58e-07 1.000 1.000 229 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(34), APC2(12), AXIN1(8), AXIN2(4), BTRC(4), CACYBP(2), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CCND1(1), CCND2(3), CCND3(2), CER1(2), CHD8(15), CREBBP(26), CSNK1A1(3), CSNK1A1L(2), CSNK1E(7), CSNK2A1(7), CSNK2A2(4), CSNK2B(1), CTBP1(3), CTBP2(5), CTNNB1(16), CTNNBIP1(1), CUL1(14), CXXC4(2), DAAM1(9), DAAM2(12), DKK1(7), DKK2(4), DKK4(1), DVL1(4), DVL2(3), DVL3(8), EP300(19), FBXW11(10), FZD1(7), FZD10(14), FZD2(7), FZD3(5), FZD4(4), FZD5(3), FZD6(5), FZD7(4), FZD8(6), FZD9(2), GSK3B(4), JUN(3), LEF1(5), LRP5(12), LRP6(6), MAP3K7(8), MAPK10(5), MAPK8(5), MAPK9(4), MMP7(2), MYC(3), NFAT5(9), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(12), NKD1(5), NKD2(1), NLK(6), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), PORCN(3), PPARD(7), PPP2CA(3), PPP2CB(2), PPP2R1A(9), PPP2R1B(4), PPP2R2A(5), PPP2R2B(5), PPP2R2C(5), PPP3CA(5), PPP3CB(6), PPP3CC(3), PPP3R2(3), PRICKLE1(13), PRICKLE2(16), PRKACA(3), PRKACB(2), PRKACG(5), PRKCA(3), PRKCG(13), PRKX(4), PSEN1(2), RAC2(2), RAC3(3), RBX1(1), RHOA(14), ROCK1(9), ROCK2(7), RUVBL1(7), SENP2(2), SFRP1(4), SFRP2(4), SFRP4(3), SFRP5(1), SIAH1(1), SMAD2(8), SMAD3(3), SMAD4(21), SOX17(5), TBL1X(5), TBL1XR1(2), TBL1Y(1), TCF7(3), TCF7L1(3), TCF7L2(8), TP53(103), VANGL1(2), VANGL2(4), WIF1(2), WNT1(5), WNT10A(4), WNT10B(1), WNT11(2), WNT16(5), WNT2(4), WNT2B(7), WNT3(5), WNT3A(4), WNT4(1), WNT5A(4), WNT5B(3), WNT6(2), WNT7A(3), WNT7B(6), WNT8A(1), WNT8B(1), WNT9A(3), WNT9B(3) 52868419 890 186 829 239 321 231 28 167 136 7 1.06e-08 1.000 1.000 230 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(16), ADCY2(12), ADCY3(5), ADCY4(5), ADCY7(13), ADCY8(21), ADCY9(8), ADORA2A(1), ADORA2B(1), ADRA1A(12), ADRA1B(4), ADRA1D(2), ADRB1(7), ADRB2(7), AGTR1(1), ATP2A1(4), ATP2A2(5), ATP2A3(5), ATP2B1(10), ATP2B2(16), ATP2B3(18), ATP2B4(2), AVPR1A(8), AVPR1B(2), BDKRB1(1), BDKRB2(3), BST1(2), CACNA1A(16), CACNA1B(22), CACNA1C(27), CACNA1D(21), CACNA1E(30), CACNA1F(9), CACNA1G(15), CACNA1H(16), CACNA1I(16), CACNA1S(11), CALM1(1), CALM2(3), CALML3(1), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CAMK4(6), CCKAR(4), CCKBR(6), CD38(3), CHRM1(2), CHRM2(13), CHRM3(9), CHRM5(1), CHRNA7(2), CYSLTR1(5), CYSLTR2(1), DRD1(3), EDNRA(3), EDNRB(20), EGFR(11), ERBB2(12), ERBB3(29), ERBB4(33), F2R(2), GNA11(5), GNA14(3), GNA15(3), GNAL(2), GNAQ(3), GNAS(20), GRIN1(4), GRIN2A(11), GRIN2C(4), GRIN2D(4), GRM1(26), GRM5(23), GRPR(7), HRH1(4), HRH2(8), HTR2A(5), HTR2B(4), HTR2C(5), HTR4(4), HTR5A(7), HTR6(2), HTR7(8), ITPKA(1), ITPKB(7), ITPR1(21), ITPR2(20), ITPR3(30), LHCGR(10), LTB4R2(2), MYLK(15), MYLK2(2), NOS1(22), NOS3(5), NTSR1(5), OXTR(5), P2RX2(6), P2RX3(4), P2RX4(5), P2RX5(4), P2RX7(1), PDE1A(6), PDE1B(3), PDE1C(5), PDGFRA(11), PDGFRB(10), PHKA1(7), PHKA2(9), PHKB(1), PHKG1(2), PHKG2(7), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), PLCD1(4), PLCD3(8), PLCD4(2), PLCE1(11), PLCG1(16), PLCG2(11), PLCZ1(3), PPID(3), PPP3CA(5), PPP3CB(6), PPP3CC(3), PPP3R2(3), PRKACA(3), PRKACB(2), PRKACG(5), PRKCA(3), PRKCG(13), PRKX(4), PTAFR(5), PTGER3(3), PTGFR(3), PTK2B(10), RYR1(43), RYR2(61), RYR3(47), SLC25A4(2), SLC25A5(2), SLC25A6(5), SLC8A1(12), SLC8A2(9), SLC8A3(8), SPHK1(4), SPHK2(2), TACR1(3), TACR2(1), TACR3(11), TBXA2R(8), TNNC1(3), TRHR(4), TRPC1(5), VDAC1(2), VDAC2(2), VDAC3(2) 88239034 1340 184 1306 521 543 346 54 284 112 1 0.104 1.000 1.000 231 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(4), ATM(30), BUB1(10), BUB1B(7), BUB3(2), CCNA1(7), CCNA2(1), CCNB1(3), CCNB2(1), CCNB3(16), CCND2(3), CCND3(2), CCNE1(3), CCNE2(2), CCNH(2), CDAN1(7), CDC14A(7), CDC14B(2), CDC20(4), CDC25A(3), CDC25B(4), CDC25C(7), CDC6(5), CDC7(3), CDH1(19), CDK2(3), CDKN1A(1), CDKN2A(6), CHEK1(4), CHEK2(7), DTX4(6), E2F1(2), E2F2(3), E2F3(2), E2F4(1), E2F5(1), E2F6(2), EP300(19), ESPL1(15), GSK3B(4), HDAC1(3), HDAC2(2), HDAC3(4), HDAC4(13), HDAC5(6), HDAC6(6), HDAC8(3), MAD1L1(8), MAD2L1(1), MCM2(11), MCM3(3), MCM4(8), MCM5(5), MCM6(2), MCM7(5), MDM2(3), MPEG1(6), ORC1L(8), ORC2L(2), ORC3L(5), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), PLK1(6), PRKDC(32), PTPRA(7), PTTG1(1), PTTG2(3), RB1(6), RBL1(7), SKP2(5), SMAD4(21), TBC1D8(7), TFDP1(3), TGFB1(3), TP53(103), WEE1(2) 36131438 549 180 502 145 156 150 23 125 91 4 0.000193 1.000 1.000 232 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ABL1(4), ANAPC1(8), ANAPC10(1), ANAPC11(1), ANAPC2(4), ANAPC5(2), ANAPC7(3), ATM(30), ATR(12), BUB1(10), BUB1B(7), BUB3(2), CCNA1(7), CCNA2(1), CCNB1(3), CCNB2(1), CCNB3(16), CCND1(1), CCND2(3), CCND3(2), CCNE1(3), CCNE2(2), CCNH(2), CDC14A(7), CDC14B(2), CDC16(4), CDC20(4), CDC23(4), CDC25A(3), CDC25B(4), CDC25C(7), CDC26(1), CDC27(2), CDC6(5), CDC7(3), CDK2(3), CDK6(4), CDKN1A(1), CDKN2A(6), CDKN2D(3), CHEK1(4), CHEK2(7), CREBBP(26), CUL1(14), DBF4(6), E2F1(2), E2F2(3), E2F3(2), EP300(19), ESPL1(15), FZR1(3), GSK3B(4), HDAC1(3), HDAC2(2), MAD1L1(8), MAD2L1(1), MCM2(11), MCM3(3), MCM4(8), MCM5(5), MCM6(2), MCM7(5), MDM2(3), ORC1L(8), ORC2L(2), ORC3L(5), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), PKMYT1(3), PLK1(6), PRKDC(32), PTTG1(1), PTTG2(3), RB1(6), RBL1(7), RBL2(4), RBX1(1), SKP2(5), SMAD2(8), SMAD3(3), SMAD4(21), SMC1A(5), SMC1B(8), TFDP1(3), TGFB1(3), TGFB2(6), TGFB3(5), TP53(103), WEE1(2), YWHAB(1), YWHAE(1), YWHAG(1), YWHAH(3), YWHAQ(2), YWHAZ(2) 44659428 613 180 565 170 182 167 21 139 100 4 0.00121 1.000 1.000 233 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(4), ADORA1(4), ADORA2A(1), ADORA2B(1), ADORA3(4), ADRA1A(12), ADRA1B(4), ADRA2A(5), ADRA2B(4), ADRA2C(4), ADRB1(7), ADRB2(7), AGTR1(1), AGTR2(2), AVPR1A(8), AVPR1B(2), AVPR2(4), BDKRB1(1), BDKRB2(3), BRS3(3), C3AR1(5), C5AR1(5), CALCR(6), CALCRL(5), CCKAR(4), CCKBR(6), CGA(1), CHRM1(2), CHRM2(13), CHRM3(9), CHRM4(2), CHRM5(1), CNR1(7), CRHR1(10), CRHR2(3), CTSG(3), CYSLTR1(5), CYSLTR2(1), DRD1(3), DRD2(7), DRD3(7), DRD4(2), DRD5(10), EDNRA(3), EDNRB(20), F2(5), F2R(2), F2RL1(2), F2RL2(2), F2RL3(1), FPR1(4), FSHB(1), FSHR(18), GABBR1(8), GABBR2(8), GABRA1(12), GABRA2(5), GABRA3(7), GABRA4(7), GABRA5(5), GABRA6(8), GABRB1(5), GABRB2(2), GABRB3(7), GABRE(5), GABRG1(2), GABRG2(9), GABRG3(5), GABRP(4), GABRQ(9), GABRR1(6), GABRR2(4), GALR1(5), GALR2(9), GALR3(1), GH1(1), GH2(3), GHR(6), GHRHR(4), GHSR(8), GIPR(3), GLP1R(1), GLP2R(8), GLRA1(4), GLRA2(3), GLRA3(4), GLRB(8), GNRHR(4), GPR156(3), GPR35(3), GPR50(7), GPR63(1), GPR83(4), GRIA1(17), GRIA2(17), GRIA3(6), GRIA4(7), GRID1(16), GRID2(14), GRIK1(8), GRIK2(11), GRIK3(12), GRIK4(9), GRIK5(10), GRIN1(4), GRIN2A(11), GRIN2B(18), GRIN2C(4), GRIN2D(4), GRIN3A(14), GRIN3B(2), GRM1(26), GRM2(19), GRM3(12), GRM4(6), GRM5(23), GRM6(8), GRM7(15), GRM8(15), GRPR(7), GZMA(1), HCRTR1(3), HCRTR2(3), HRH1(4), HRH2(8), HRH3(3), HRH4(3), HTR1A(10), HTR1B(8), HTR1D(3), HTR1E(5), HTR1F(5), HTR2A(5), HTR2B(4), HTR2C(5), HTR4(4), HTR5A(7), HTR6(2), HTR7(8), LEPR(13), LHCGR(10), LTB4R(1), LTB4R2(2), MAS1(1), MC2R(2), MC3R(3), MC4R(5), MC5R(5), MCHR1(5), MCHR2(4), MLNR(2), MTNR1A(4), MTNR1B(6), NMBR(3), NMUR1(3), NMUR2(3), NPBWR1(10), NPBWR2(6), NPFFR1(1), NPFFR2(8), NPY1R(3), NPY2R(3), NPY5R(3), NR3C1(5), NTSR1(5), NTSR2(3), OPRD1(1), OPRK1(6), OPRL1(6), OPRM1(3), OXTR(5), P2RX2(6), P2RX3(4), P2RX4(5), P2RX5(4), P2RX7(1), P2RY1(3), P2RY10(10), P2RY13(2), P2RY14(4), P2RY2(5), P2RY4(2), P2RY6(6), P2RY8(5), PARD3(9), PPYR1(6), PRL(1), PRLHR(4), PRLR(2), PRSS1(2), PRSS3(3), PTAFR(5), PTGDR(6), PTGER2(4), PTGER3(3), PTGER4(4), PTGFR(3), PTH2R(5), RXFP1(6), RXFP2(6), SCTR(2), SSTR1(9), SSTR2(3), SSTR3(5), SSTR4(11), SSTR5(4), TAAR1(2), TAAR2(3), TAAR5(5), TAAR6(6), TAAR9(1), TACR1(3), TACR2(1), TACR3(11), TBXA2R(8), THRA(4), THRB(7), TRHR(4), TRPV1(6), TSHB(2), TSHR(8), UTS2R(1), VIPR1(2), VIPR2(3) 72662519 1247 176 1223 468 469 319 56 326 76 1 0.0164 1.000 1.000 234 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(3), ACTN1(6), ACTN2(22), ACTN3(2), ACTN4(6), APC(34), APC2(12), ARAF(8), ARHGEF1(9), ARHGEF12(8), ARHGEF4(5), ARHGEF6(12), ARHGEF7(7), ARPC1A(3), ARPC2(1), ARPC4(2), BAIAP2(4), BCAR1(4), BDKRB1(1), BDKRB2(3), BRAF(9), CD14(2), CDC42(1), CFL1(1), CHRM1(2), CHRM2(13), CHRM3(9), CHRM4(2), CHRM5(1), CRK(1), CRKL(1), CSK(5), CYFIP1(11), CYFIP2(13), DIAPH1(7), DIAPH2(6), DIAPH3(9), DOCK1(15), EGF(8), EGFR(11), EZR(3), F2(5), F2R(2), FGD1(10), FGD3(10), FGF1(2), FGF10(5), FGF11(1), FGF12(5), FGF13(7), FGF14(6), FGF17(4), FGF18(2), FGF2(2), FGF20(3), FGF21(2), FGF22(1), FGF23(1), FGF3(1), FGF5(1), FGF6(5), FGF7(2), FGF8(1), FGF9(6), FGFR1(11), FGFR2(8), FGFR3(3), FGFR4(6), FN1(23), GIT1(3), GNA12(1), GNA13(3), GNG12(1), GRLF1(15), GSN(9), IQGAP1(11), IQGAP2(8), IQGAP3(12), ITGA1(7), ITGA10(5), ITGA11(7), ITGA2(5), ITGA2B(7), ITGA3(7), ITGA4(9), ITGA5(4), ITGA6(4), ITGA7(7), ITGA8(5), ITGA9(7), ITGAD(9), ITGAE(6), ITGAL(11), ITGAM(6), ITGAV(5), ITGAX(8), ITGB1(6), ITGB2(5), ITGB3(3), ITGB4(12), ITGB5(5), ITGB6(3), ITGB7(4), ITGB8(8), KRAS(25), LIMK1(3), LIMK2(1), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK3(1), MOS(9), MSN(9), MYH10(24), MYH14(12), MYH9(23), MYL2(6), MYL7(1), MYL9(2), MYLK(15), MYLK2(2), NCKAP1(8), NCKAP1L(10), NRAS(2), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PAK7(7), PDGFA(2), PDGFB(5), PDGFRA(11), PDGFRB(10), PFN2(2), PFN3(2), PIK3CA(62), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PIP4K2A(4), PIP4K2B(2), PIP4K2C(1), PIP5K1A(3), PIP5K1B(1), PIP5K1C(8), PPP1CA(2), PPP1CB(1), PPP1CC(4), PPP1R12A(2), PPP1R12B(12), PTK2(10), PXN(3), RAC2(2), RAC3(3), RAF1(7), RDX(4), RHOA(14), ROCK1(9), ROCK2(7), RRAS(1), RRAS2(3), SCIN(5), SLC9A1(8), SOS1(6), SOS2(11), SSH1(7), SSH2(17), SSH3(6), TIAM1(28), TIAM2(20), TMSL3(1), VAV1(6), VAV2(11), VAV3(10), VCL(1), WAS(1), WASF1(3), WASF2(6), WASL(1) 90612588 1244 175 1171 448 432 363 43 271 131 4 0.0485 1.000 1.000 235 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(4), ABLIM1(9), ABLIM2(3), ABLIM3(4), ARHGEF12(8), CDC42(1), CDK5(2), CFL1(1), CXCR4(1), DCC(22), DPYSL2(1), DPYSL5(6), EFNA1(2), EFNA2(1), EFNA4(1), EFNA5(2), EFNB1(2), EFNB2(3), EFNB3(3), EPHA1(10), EPHA2(9), EPHA3(15), EPHA4(14), EPHA5(22), EPHA6(22), EPHA7(4), EPHA8(11), EPHB1(18), EPHB2(8), EPHB3(11), EPHB4(8), EPHB6(8), FES(6), FYN(8), GNAI1(1), GNAI2(2), GNAI3(6), GSK3B(4), ITGB1(6), KRAS(25), L1CAM(12), LIMK1(3), LIMK2(1), LRRC4C(2), MAPK1(2), MAPK3(1), MET(7), NCK1(6), NCK2(3), NFAT5(9), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(12), NGEF(6), NRAS(2), NRP1(13), NTN1(6), NTN4(2), NTNG1(14), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PAK7(7), PLXNA1(24), PLXNA2(17), PLXNA3(11), PLXNB1(10), PLXNB2(11), PLXNB3(11), PLXNC1(14), PPP3CA(5), PPP3CB(6), PPP3CC(3), PPP3R2(3), PTK2(10), RAC2(2), RAC3(3), RASA1(11), RGS3(13), RHOA(14), RHOD(1), RND1(1), ROBO1(21), ROBO2(21), ROBO3(6), ROCK1(9), ROCK2(7), SEMA3A(14), SEMA3B(4), SEMA3C(6), SEMA3D(10), SEMA3E(9), SEMA3F(10), SEMA3G(5), SEMA4A(5), SEMA4B(5), SEMA4C(4), SEMA4D(11), SEMA4F(6), SEMA4G(1), SEMA5A(20), SEMA5B(13), SEMA6A(13), SEMA6B(3), SEMA6C(6), SEMA6D(15), SEMA7A(8), SLIT1(5), SLIT2(23), SLIT3(11), SRGAP1(11), SRGAP2(5), SRGAP3(7), UNC5A(8), UNC5B(6), UNC5C(12), UNC5D(12) 64561175 959 168 928 361 307 253 57 241 98 3 0.272 1.000 1.000 236 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(7), CHAD(2), COL11A1(18), COL11A2(7), COL17A1(6), COL1A1(6), COL1A2(23), COL2A1(13), COL3A1(7), COL4A1(18), COL4A2(10), COL4A4(10), COL4A6(6), COL5A1(21), COL5A2(11), COL5A3(10), COL6A1(7), COL6A2(15), COL6A3(36), COL6A6(27), COMP(2), DES(1), DSC1(1), DSC2(9), DSC3(2), DSG1(4), DSG2(3), DSG3(9), DSG4(7), FN1(23), GJA1(9), GJA10(3), GJA3(1), GJA4(2), GJA5(3), GJA8(3), GJA9(3), GJB3(3), GJB4(2), GJB5(1), GJB6(5), GJB7(1), GJC1(1), GJC2(2), GJD2(3), GJD4(5), IBSP(2), INA(5), ITGA6(4), ITGB4(12), KRT1(4), KRT10(6), KRT12(3), KRT13(8), KRT14(2), KRT15(1), KRT16(7), KRT17(4), KRT18(2), KRT19(1), KRT2(8), KRT20(4), KRT23(8), KRT24(3), KRT25(6), KRT27(6), KRT28(8), KRT3(8), KRT31(5), KRT32(4), KRT33A(7), KRT33B(4), KRT34(5), KRT35(5), KRT36(5), KRT37(3), KRT38(3), KRT39(7), KRT4(4), KRT40(1), KRT5(2), KRT6A(10), KRT6B(3), KRT6C(8), KRT7(2), KRT71(2), KRT72(5), KRT73(10), KRT74(2), KRT75(2), KRT76(3), KRT77(2), KRT78(2), KRT79(3), KRT8(5), KRT81(3), KRT82(2), KRT83(3), KRT84(4), KRT85(2), KRT86(2), KRT9(1), LAMA1(36), LAMA2(23), LAMA3(17), LAMA4(14), LAMA5(23), LAMB1(11), LAMB2(16), LAMB3(14), LAMB4(13), LAMC1(11), LAMC2(7), LAMC3(13), LMNA(3), LMNB1(1), LMNB2(4), NES(5), PRPH(3), RELN(37), SPP1(3), THBS1(12), THBS2(7), THBS3(6), THBS4(10), TNC(17), TNN(17), TNR(18), TNXB(38), VIM(8), VTN(4), VWF(19) 81726449 1021 167 1012 479 359 276 41 255 89 1 0.995 1.000 1.000 237 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTB(7), ACTN1(6), ACTN2(22), ACTN3(2), ACTN4(6), AKT1(3), AKT2(6), AKT3(6), AMOTL1(5), ASH1L(28), CASK(2), CDC42(1), CGN(7), CLDN1(2), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(4), CLDN18(2), CLDN19(3), CLDN20(3), CLDN22(2), CLDN23(2), CLDN3(1), CLDN4(5), CLDN5(2), CLDN6(4), CLDN8(1), CLDN9(3), CSDA(4), CSNK2A1(7), CSNK2A2(4), CSNK2B(1), CTNNA1(11), CTNNA2(16), CTNNA3(9), CTNNB1(16), CTTN(5), EPB41(7), EPB41L1(5), EPB41L2(8), EPB41L3(19), EXOC3(3), EXOC4(7), F11R(2), GNAI1(1), GNAI2(2), GNAI3(6), HCLS1(3), IGSF5(2), INADL(9), JAM2(2), JAM3(4), KRAS(25), LLGL1(8), LLGL2(5), MAGI1(14), MAGI2(23), MAGI3(4), MLLT4(18), MPDZ(18), MPP5(1), MYH1(17), MYH10(24), MYH11(18), MYH13(20), MYH14(12), MYH15(10), MYH2(23), MYH3(23), MYH4(16), MYH6(24), MYH7(15), MYH7B(15), MYH8(13), MYH9(23), MYL2(6), MYL7(1), MYL9(2), NRAS(2), OCLN(4), PARD3(9), PARD6A(1), PARD6B(3), PARD6G(3), PPM1J(2), PPP2CA(3), PPP2CB(2), PPP2R1A(9), PPP2R1B(4), PPP2R2A(5), PPP2R2B(5), PPP2R2C(5), PPP2R3A(7), PPP2R3B(6), PPP2R4(3), PRKCA(3), PRKCD(7), PRKCE(8), PRKCG(13), PRKCH(6), PRKCI(4), PRKCQ(7), PTEN(18), RAB13(2), RAB3B(3), RHOA(14), RRAS(1), RRAS2(3), SPTAN1(18), SRC(2), SYMPK(5), TJAP1(2), TJP1(11), TJP2(8), TJP3(6), VAPA(1), YES1(2), ZAK(7) 63688965 901 164 865 297 302 254 32 228 84 1 0.0100 1.000 1.000 238 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(6), CD36(2), CD44(4), CHAD(2), COL11A1(18), COL11A2(7), COL1A1(6), COL1A2(23), COL2A1(13), COL3A1(7), COL4A1(18), COL4A2(10), COL4A4(10), COL4A6(6), COL5A1(21), COL5A2(11), COL5A3(10), COL6A1(7), COL6A2(15), COL6A3(36), COL6A6(27), DAG1(8), FN1(23), FNDC1(13), FNDC3A(6), FNDC4(2), FNDC5(1), GP5(5), GP6(3), GP9(1), HMMR(7), HSPG2(22), IBSP(2), ITGA1(7), ITGA10(5), ITGA11(7), ITGA2(5), ITGA2B(7), ITGA3(7), ITGA4(9), ITGA5(4), ITGA6(4), ITGA7(7), ITGA8(5), ITGA9(7), ITGAV(5), ITGB1(6), ITGB3(3), ITGB4(12), ITGB5(5), ITGB6(3), ITGB7(4), ITGB8(8), LAMA1(36), LAMA2(23), LAMA3(17), LAMA4(14), LAMA5(23), LAMB1(11), LAMB2(16), LAMB3(14), LAMB4(13), LAMC1(11), LAMC2(7), LAMC3(13), RELN(37), SDC1(1), SDC2(2), SDC3(4), SDC4(3), SPP1(3), SV2A(10), SV2B(2), SV2C(6), THBS1(12), THBS2(7), THBS3(6), THBS4(10), TNC(17), TNN(17), TNR(18), TNXB(38), VTN(4), VWF(19) 73529504 886 163 876 406 315 221 33 226 90 1 0.978 1.000 1.000 239 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(16), ADCY2(12), ADCY3(5), ADCY4(5), ADCY5(11), ADCY6(10), ADCY7(13), ADCY8(21), ADCY9(8), ADRA1A(12), ADRA1B(4), ADRA1D(2), ADRB1(7), ADRB2(7), ANXA6(2), ARRB1(3), ATP1A4(12), ATP1B1(1), ATP1B2(2), ATP1B3(3), ATP2A2(5), ATP2A3(5), ATP2B1(10), ATP2B2(16), ATP2B3(18), CACNA1A(16), CACNA1B(22), CACNA1C(27), CACNA1D(21), CACNA1E(30), CACNA1S(11), CACNB1(1), CACNB3(2), CALM1(1), CALM2(3), CALR(3), CAMK1(2), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CAMK4(6), CASQ1(6), CASQ2(2), CHRM1(2), CHRM2(13), CHRM3(9), CHRM4(2), CHRM5(1), GJA1(9), GJA4(2), GJA5(3), GJB3(3), GJB4(2), GJB5(1), GJB6(5), GNA11(5), GNAI2(2), GNAI3(6), GNAQ(3), GNAZ(11), GNB2(4), GNB4(3), GNG12(1), GNG13(2), GNG7(3), GNGT1(3), GRK6(2), ITPR1(21), ITPR2(20), ITPR3(30), KCNB1(8), KCNJ3(9), KCNJ5(3), MIB1(4), NME7(1), PKIA(1), PKIG(2), PLCB3(8), PRKACA(3), PRKACB(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKCA(3), PRKCD(7), PRKCE(8), PRKCG(13), PRKCH(6), PRKCQ(7), PRKD1(16), RGS1(2), RGS10(3), RGS11(1), RGS14(2), RGS16(3), RGS17(2), RGS18(4), RGS19(2), RGS2(2), RGS20(4), RGS3(13), RGS4(3), RGS5(3), RGS6(14), RGS7(2), RGS9(8), RYR1(43), RYR2(61), RYR3(47), SLC8A1(12), SLC8A3(8), USP5(4), YWHAB(1), YWHAH(3), YWHAQ(2) 61531238 908 162 897 370 361 231 40 192 83 1 0.369 1.000 1.000 240 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(6), CADM1(11), CADM3(5), CD2(2), CD22(3), CD226(2), CD274(1), CD276(6), CD34(3), CD4(5), CD40(1), CD40LG(4), CD58(1), CD6(5), CD80(1), CD86(2), CD8A(4), CD8B(2), CD99(1), CDH1(19), CDH15(4), CDH2(11), CDH3(8), CDH4(17), CDH5(5), CLDN1(2), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(4), CLDN18(2), CLDN19(3), CLDN20(3), CLDN22(2), CLDN23(2), CLDN3(1), CLDN4(5), CLDN5(2), CLDN6(4), CLDN8(1), CLDN9(3), CNTN1(15), CNTN2(7), CNTNAP1(15), CNTNAP2(29), CTLA4(3), ESAM(5), F11R(2), GLG1(13), HLA-A(6), HLA-B(12), HLA-C(3), HLA-DMA(1), HLA-DMB(3), HLA-DOA(1), HLA-DPB1(2), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(6), HLA-E(3), HLA-F(7), HLA-G(3), ICAM1(1), ICAM2(2), ICAM3(1), ICOS(1), ITGA4(9), ITGA6(4), ITGA8(5), ITGA9(7), ITGAL(11), ITGAM(6), ITGAV(5), ITGB1(6), ITGB2(5), ITGB7(4), ITGB8(8), JAM2(2), JAM3(4), L1CAM(12), MAG(9), MPZ(2), MPZL1(1), NCAM1(4), NCAM2(16), NEGR1(6), NEO1(10), NFASC(15), NLGN1(13), NLGN2(8), NLGN3(10), NRCAM(8), NRXN1(27), NRXN2(20), NRXN3(21), OCLN(4), PDCD1(2), PDCD1LG2(1), PTPRC(15), PTPRF(15), PTPRM(25), PVR(2), PVRL1(1), PVRL2(4), PVRL3(4), SDC1(1), SDC2(2), SDC3(4), SDC4(3), SELE(4), SELL(4), SELP(6), SELPLG(6), SIGLEC1(9), SPN(3), VCAM1(8), VCAN(35) 48408219 734 159 720 284 243 217 23 183 67 1 0.166 1.000 1.000 241 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(30), CCNA1(7), CCNB1(3), CCND1(1), CCND2(3), CCND3(2), CCNE1(3), CCNE2(2), CCNH(2), CDC25A(3), CDK2(3), CDKN1A(1), CDKN2A(6), CDKN2D(3), CREB3(4), CREB3L1(3), CREB3L3(3), CREB3L4(1), E2F1(2), E2F2(3), E2F3(2), E2F4(1), E2F5(1), E2F6(2), MCM2(11), MCM3(3), MCM4(8), MCM5(5), MCM6(2), MCM7(5), MDM2(3), MNAT1(2), MYC(3), MYT1(14), NACA(2), ORC1L(8), ORC2L(2), ORC3L(5), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), POLA2(3), POLE(17), POLE2(3), PRIM1(2), RB1(6), RBL1(7), RPA1(1), RPA2(1), RPA3(2), TFDP1(3), TFDP2(3), TNXB(38), TP53(103), WEE1(2) 25324874 364 156 322 95 123 93 15 66 64 3 0.000250 1.000 1.000 242 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA1(4), ADORA2A(1), ADORA2B(1), ADORA3(4), ADRA1A(12), ADRA1B(4), ADRA1D(2), ADRA2A(5), ADRA2C(4), ADRB1(7), ADRB2(7), AGTR1(1), AGTR2(2), AVPR1A(8), AVPR1B(2), AVPR2(4), BDKRB1(1), BDKRB2(3), BRS3(3), C3AR1(5), CCBP2(2), CCKAR(4), CCKBR(6), CCR1(2), CCR10(2), CCR2(5), CCR3(6), CCR5(3), CCR6(1), CCR7(2), CCR8(1), CCR9(3), CCRL1(5), CHML(3), CHRM1(2), CHRM2(13), CHRM3(9), CHRM4(2), CHRM5(1), CMKLR1(2), CNR1(7), CX3CR1(3), CXCR4(1), DRD1(3), DRD2(7), DRD3(7), DRD4(2), DRD5(10), EDNRA(3), EDNRB(20), F2R(2), F2RL1(2), F2RL2(2), F2RL3(1), FPR1(4), FSHR(18), GALR1(5), GALR2(9), GALR3(1), GALT(1), GHSR(8), GNB2L1(4), GPR17(1), GPR173(3), GPR174(3), GPR27(5), GPR3(4), GPR35(3), GPR37(9), GPR37L1(4), GPR4(2), GPR50(7), GPR6(9), GPR63(1), GPR77(1), GPR83(4), GPR85(2), GPR87(4), GRPR(7), HCRTR1(3), HCRTR2(3), HRH1(4), HRH2(8), HRH3(3), HTR1A(10), HTR1B(8), HTR1D(3), HTR1E(5), HTR1F(5), HTR2A(5), HTR2B(4), HTR2C(5), HTR4(4), HTR5A(7), HTR6(2), HTR7(8), LHCGR(10), LTB4R(1), MAS1(1), MC3R(3), MC4R(5), MC5R(5), MLNR(2), MTNR1A(4), MTNR1B(6), NMBR(3), NMUR1(3), NMUR2(3), NPY1R(3), NPY2R(3), NPY5R(3), NTSR1(5), NTSR2(3), OPN1SW(1), OPN3(4), OPRD1(1), OPRK1(6), OPRL1(6), OPRM1(3), OR10A5(5), OR11A1(5), OR12D3(1), OR1C1(2), OR1F1(3), OR1Q1(5), OR2H1(2), OR5V1(6), OR7C1(2), OR8B8(5), OXTR(5), P2RY1(3), P2RY10(10), P2RY12(6), P2RY13(2), P2RY14(4), P2RY2(5), P2RY6(6), PPYR1(6), PTAFR(5), PTGDR(6), PTGER2(4), PTGER4(4), PTGFR(3), RGR(1), RHO(6), RRH(2), SSTR1(9), SSTR2(3), SSTR3(5), SSTR4(11), SUCNR1(4), TBXA2R(8), TRHR(4) 39858357 672 151 660 258 252 182 27 165 46 0 0.0335 1.000 1.000 243 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACTB(7), ACTN1(6), ACTN2(22), ACTN3(2), ACTN4(6), ACVR1B(12), ACVR1C(3), BAIAP2(4), CDC42(1), CDH1(19), CREBBP(26), CSNK2A1(7), CSNK2A2(4), CSNK2B(1), CTNNA1(11), CTNNA2(16), CTNNA3(9), CTNNB1(16), CTNND1(13), EGFR(11), EP300(19), ERBB2(12), FARP2(3), FER(9), FGFR1(11), FYN(8), IGF1R(15), INSR(12), IQGAP1(11), LEF1(5), LMO7(11), MAP3K7(8), MAPK1(2), MAPK3(1), MET(7), MLLT4(18), NLK(6), PARD3(9), PTPN1(2), PTPN6(3), PTPRB(17), PTPRF(15), PTPRJ(21), PTPRM(25), PVRL1(1), PVRL2(4), PVRL3(4), PVRL4(6), RAC2(2), RAC3(3), RHOA(14), SMAD2(8), SMAD3(3), SMAD4(21), SNAI1(3), SNAI2(8), SORBS1(7), SRC(2), SSX2IP(6), TCF7(3), TCF7L1(3), TCF7L2(8), TGFBR1(5), TGFBR2(11), TJP1(11), VCL(1), WAS(1), WASF1(3), WASF2(6), WASF3(6), WASL(1), YES1(2) 39348489 599 149 576 188 179 184 20 131 84 1 0.00511 1.000 1.000 244 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(4), ABL2(6), AKT1(3), AKT2(6), AKT3(6), ARAF(8), BAD(3), BRAF(9), BTC(1), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CBL(2), CBLB(3), CBLC(2), CDKN1A(1), CRK(1), CRKL(1), EGF(8), EGFR(11), EIF4EBP1(2), ELK1(3), ERBB2(12), ERBB3(29), ERBB4(33), EREG(3), GAB1(2), GRB2(4), GSK3B(4), HBEGF(2), JUN(3), KRAS(25), MAP2K1(5), MAP2K2(2), MAP2K4(7), MAP2K7(20), MAPK1(2), MAPK10(5), MAPK3(1), MAPK8(5), MAPK9(4), MYC(3), NCK1(6), NCK2(3), NRAS(2), NRG1(11), NRG2(6), NRG3(13), NRG4(1), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PAK7(7), PIK3CA(62), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PLCG1(16), PLCG2(11), PRKCA(3), PRKCG(13), PTK2(10), RAF1(7), RPS6KB1(4), RPS6KB2(3), SHC1(3), SHC2(2), SHC3(8), SHC4(1), SOS1(6), SOS2(11), SRC(2), STAT5A(4), STAT5B(6), TGFA(2) 33759194 571 148 500 153 184 188 24 121 54 0 9.28e-06 1.000 1.000 245 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1(5), ACVR1B(12), ACVR2A(6), ACVR2B(3), AMHR2(2), BMP2(2), BMP7(5), BMPR1A(3), BMPR1B(4), BMPR2(11), CCL1(2), CCL11(1), CCL15(2), CCL16(1), CCL18(2), CCL19(1), CCL2(1), CCL20(1), CCL22(1), CCL23(1), CCL24(1), CCL25(1), CCL27(1), CCL5(1), CCL7(1), CCL8(2), CCR1(2), CCR2(5), CCR3(6), CCR5(3), CCR6(1), CCR7(2), CCR8(1), CCR9(3), CD27(2), CD40(1), CD40LG(4), CD70(1), CLCF1(2), CNTF(3), CNTFR(2), CSF1(1), CSF1R(7), CSF2RA(8), CSF2RB(7), CSF3(1), CSF3R(6), CX3CL1(6), CX3CR1(3), CXCL10(1), CXCL16(3), CXCL2(2), CXCL9(2), CXCR4(1), CXCR6(2), EDA(1), EDA2R(3), EDAR(5), EGF(8), EGFR(11), EPOR(2), FAS(3), FASLG(2), FLT1(13), FLT3(8), FLT4(17), GDF5(7), GH1(1), GH2(3), GHR(6), HGF(13), IFNA1(1), IFNA10(5), IFNA13(1), IFNA16(2), IFNA17(4), IFNA2(1), IFNA21(1), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(4), IFNA8(1), IFNAR1(5), IFNAR2(6), IFNB1(2), IFNG(2), IFNGR1(5), IFNGR2(1), IFNK(1), IFNW1(2), IL10(2), IL10RA(4), IL10RB(2), IL11(2), IL11RA(2), IL12A(2), IL12B(1), IL12RB1(4), IL12RB2(8), IL13(1), IL13RA1(3), IL15RA(3), IL17B(3), IL17RA(6), IL17RB(1), IL18(1), IL18R1(2), IL18RAP(2), IL1A(2), IL1B(2), IL1R1(4), IL1R2(5), IL1RAP(5), IL20(1), IL20RA(6), IL21(2), IL21R(9), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(5), IL25(1), IL26(4), IL28A(2), IL28B(3), IL28RA(1), IL2RA(2), IL2RB(2), IL2RG(5), IL3(1), IL3RA(5), IL4(1), IL4R(1), IL5RA(4), IL6R(1), IL6ST(4), IL7(1), IL7R(5), IL8(1), IL9R(3), INHBA(7), INHBB(8), INHBC(3), INHBE(1), KDR(8), KIT(12), KITLG(2), LEPR(13), LIF(1), LIFR(10), LTA(3), LTBR(1), MET(7), NGFR(4), OSM(2), OSMR(4), PDGFB(5), PDGFC(5), PDGFRA(11), PDGFRB(10), PF4V1(1), PLEKHO2(1), PRL(1), PRLR(2), RELT(2), TGFB1(3), TGFB2(6), TGFB3(5), TGFBR1(5), TGFBR2(11), TNF(1), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10C(1), TNFRSF10D(3), TNFRSF11A(3), TNFRSF11B(2), TNFRSF13B(3), TNFRSF13C(2), TNFRSF17(1), TNFRSF19(7), TNFRSF1A(3), TNFRSF1B(1), TNFRSF21(5), TNFRSF25(4), TNFRSF4(2), TNFRSF8(2), TNFRSF9(6), TNFSF10(3), TNFSF11(1), TNFSF13B(3), TNFSF14(2), TNFSF15(2), TNFSF18(2), TNFSF4(1), TNFSF8(3), TPO(15), TSLP(3), VEGFC(8), XCL1(1), XCR1(3) 58113564 703 148 687 284 219 205 33 171 73 2 0.492 1.000 1.000 246 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(19), ACACB(22), AKT1(3), AKT2(6), AKT3(6), ARAF(8), BAD(3), BRAF(9), CALM1(1), CALM2(3), CALML3(1), CBL(2), CBLB(3), CBLC(2), CRK(1), CRKL(1), EIF4EBP1(2), ELK1(3), EXOC7(7), FASN(14), FBP1(2), FBP2(4), FLOT1(2), FLOT2(3), FOXO1(3), G6PC2(1), GCK(4), GRB2(4), GSK3B(4), GYS1(3), GYS2(4), IKBKB(7), INPP5D(1), INSR(12), IRS1(15), IRS2(4), IRS4(16), KRAS(25), LIPE(6), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK10(5), MAPK3(1), MAPK8(5), MAPK9(4), MKNK1(3), MKNK2(1), NRAS(2), PCK1(6), PCK2(7), PDE3A(11), PDE3B(13), PDPK1(2), PFKL(4), PFKM(3), PFKP(8), PHKA1(7), PHKA2(9), PHKB(1), PHKG1(2), PHKG2(7), PIK3CA(62), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PKLR(5), PKM2(5), PPARGC1A(9), PPP1CA(2), PPP1CB(1), PPP1CC(4), PPP1R3A(21), PPP1R3B(6), PPP1R3C(3), PPP1R3D(2), PRKAA1(4), PRKAA2(5), PRKAB1(2), PRKAB2(2), PRKACA(3), PRKACB(2), PRKACG(5), PRKAG1(3), PRKAG2(3), PRKAG3(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKCI(4), PRKX(4), PTPN1(2), PTPRF(15), PYGB(8), PYGL(6), PYGM(9), RAF1(7), RAPGEF1(9), RHEB(1), RPS6(1), RPS6KB1(4), RPS6KB2(3), SH2B2(2), SHC1(3), SHC2(2), SHC3(8), SHC4(1), SLC2A4(4), SOCS1(1), SOCS2(2), SOCS3(3), SOCS4(3), SORBS1(7), SOS1(6), SOS2(11), SREBF1(8), TRIP10(7), TSC1(3), TSC2(7) 52434935 722 148 662 242 254 229 22 144 73 0 0.00288 1.000 1.000 247 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(2), ACTA2(6), ACTN2(22), ACTN3(2), ACTN4(6), DES(1), DMD(48), FAM48A(7), MYBPC1(5), MYBPC2(7), MYBPC3(4), MYH3(23), MYH6(24), MYH7(15), MYH8(13), MYL1(1), MYL2(6), MYL3(2), MYL9(2), MYOM1(6), NEB(48), TMOD1(2), TNNI1(1), TNNI2(4), TNNT1(3), TNNT2(2), TPM1(4), TPM3(3), TPM4(3), TTN(401), VIM(8) 44816195 681 148 669 221 178 188 40 232 38 5 0.0626 1.000 1.000 248 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(2), ACTA2(6), ADCY1(16), ADCY2(12), ADCY3(5), ADCY4(5), ADCY5(11), ADCY6(10), ADCY7(13), ADCY8(21), ADCY9(8), ARRB1(3), ATF2(1), ATF5(2), ATP2A2(5), ATP2A3(5), CACNB3(2), CALCA(1), CALM1(1), CALM2(3), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CNN1(2), CNN2(1), CORIN(13), CREB3(4), CRHR1(10), DGKZ(4), ETS2(3), FOS(1), GABPA(2), GABPB2(2), GJA1(9), GNAQ(3), GNB2(4), GNB4(3), GNG12(1), GNG13(2), GNG7(3), GNGT1(3), GRK6(2), GUCA2A(1), GUCY1A3(14), IGFBP1(5), IGFBP2(2), IGFBP3(5), IGFBP4(1), IGFBP6(1), IL1B(2), ITPR1(21), ITPR2(20), ITPR3(30), JUN(3), MIB1(4), MYL2(6), MYLK2(2), NFKB1(7), NOS1(22), NOS3(5), OXT(1), OXTR(5), PDE4B(4), PDE4D(1), PKIA(1), PKIG(2), PLCB3(8), PLCD1(4), PLCG1(16), PLCG2(11), PRKACA(3), PRKACB(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKCA(3), PRKCD(7), PRKCE(8), PRKCH(6), PRKCQ(7), PRKD1(16), RAMP3(3), RGS1(2), RGS10(3), RGS11(1), RGS14(2), RGS16(3), RGS17(2), RGS18(4), RGS19(2), RGS2(2), RGS20(4), RGS3(13), RGS4(3), RGS5(3), RGS6(14), RGS7(2), RGS9(8), RLN1(1), RYR1(43), RYR2(61), RYR3(47), SLC8A1(12), SP1(6), TNXB(38), USP5(4), YWHAB(1), YWHAH(3), YWHAQ(2) 56801553 776 147 767 315 302 188 32 182 71 1 0.451 1.000 1.000 249 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 BAK1(3), BAX(1), BFAR(2), BTK(2), CAD(12), CASP10(5), CASP3(2), CASP8(8), CASP8AP2(7), CD7(3), CSNK1A1(3), DAXX(9), DEDD(2), DEDD2(1), DFFA(4), DIABLO(1), EGFR(11), EPHB2(8), FAF1(8), FAIM2(1), IL1A(2), IL8(1), MAP2K4(7), MAP2K7(20), MAP3K1(9), MAP3K5(4), MAPK1(2), MAPK10(5), MAPK8(5), MAPK8IP1(2), MAPK8IP2(3), MAPK8IP3(10), MAPK9(4), MET(7), NFAT5(9), NFKB1(7), NFKB2(2), NFKBIA(1), NFKBIB(5), NFKBIL1(2), NFKBIL2(7), NR0B2(2), PFN2(2), PTPN13(16), RALBP1(5), RIPK1(1), ROCK1(9), SMPD1(5), TP53(103), TPX2(6), TRAF2(2), TUFM(3) 23865772 361 147 321 96 117 90 9 72 71 2 0.000923 1.000 1.000 250 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(16), ADCY2(12), ADCY3(5), ADCY4(5), ADCY5(11), ADCY6(10), ADCY7(13), ADCY8(21), ADCY9(8), ADRB1(7), CSNK1D(2), DRD1(3), DRD2(7), EGF(8), EGFR(11), GJA1(9), GJD2(3), GNA11(5), GNAI1(1), GNAI2(2), GNAI3(6), GNAQ(3), GNAS(20), GRB2(4), GRM1(26), GRM5(23), GUCY1A2(8), GUCY1A3(14), GUCY1B3(7), GUCY2C(7), GUCY2D(12), GUCY2F(13), HTR2A(5), HTR2B(4), HTR2C(5), ITPR1(21), ITPR2(20), ITPR3(30), KRAS(25), MAP2K1(5), MAP2K2(2), MAP2K5(1), MAP3K2(3), MAPK1(2), MAPK3(1), MAPK7(7), NPR1(9), NPR2(7), NRAS(2), PDGFA(2), PDGFB(5), PDGFC(5), PDGFD(5), PDGFRA(11), PDGFRB(10), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), PRKACA(3), PRKACB(2), PRKACG(5), PRKCA(3), PRKCG(13), PRKG1(8), PRKG2(10), PRKX(4), RAF1(7), SOS1(6), SOS2(11), SRC(2), TJP1(11), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3C(5), TUBA3D(4), TUBA3E(9), TUBA4A(1), TUBA8(4), TUBAL3(4), TUBB1(3), TUBB2A(2), TUBB2B(1), TUBB2C(3), TUBB3(12), TUBB4(4), TUBB4Q(4), TUBB6(7), TUBB8(3) 43365976 678 144 646 255 237 197 26 171 46 1 0.210 1.000 1.000 251 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(3), AKT2(6), AKT3(6), CBL(2), CBLB(3), CBLC(2), CCND1(1), CCND2(3), CCND3(2), CISH(1), CLCF1(2), CNTF(3), CNTFR(2), CREBBP(26), CSF2RA(8), CSF2RB(7), CSF3(1), CSF3R(6), EP300(19), EPOR(2), GH1(1), GH2(3), GHR(6), GRB2(4), IFNA1(1), IFNA10(5), IFNA13(1), IFNA16(2), IFNA17(4), IFNA2(1), IFNA21(1), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(4), IFNA8(1), IFNAR1(5), IFNAR2(6), IFNB1(2), IFNG(2), IFNGR1(5), IFNGR2(1), IFNK(1), IFNW1(2), IL10(2), IL10RA(4), IL10RB(2), IL11(2), IL11RA(2), IL12A(2), IL12B(1), IL12RB1(4), IL12RB2(8), IL13(1), IL13RA1(3), IL13RA2(6), IL15RA(3), IL20(1), IL20RA(6), IL21(2), IL21R(9), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(5), IL26(4), IL28A(2), IL28B(3), IL28RA(1), IL2RA(2), IL2RB(2), IL2RG(5), IL3(1), IL3RA(5), IL4(1), IL4R(1), IL5RA(4), IL6R(1), IL6ST(4), IL7(1), IL7R(5), IL9R(3), IRF9(3), JAK1(6), JAK2(10), JAK3(9), LEPR(13), LIF(1), LIFR(10), MYC(3), OSM(2), OSMR(4), PIAS1(6), PIAS2(7), PIAS3(2), PIAS4(5), PIK3CA(62), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PIM1(2), PRL(1), PRLR(2), PTPN11(5), PTPN6(3), SOCS1(1), SOCS2(2), SOCS3(3), SOCS4(3), SOCS5(7), SOCS7(3), SOS1(6), SOS2(11), SPRED1(10), SPRED2(6), SPRY1(2), SPRY3(6), SPRY4(4), STAM(5), STAM2(4), STAT1(7), STAT2(4), STAT3(6), STAT4(3), STAT5A(4), STAT5B(6), STAT6(1), TPO(15), TSLP(3), TYK2(4) 47680088 620 143 576 197 180 201 31 151 57 0 0.00492 1.000 1.000 252 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(6), ADCY1(16), ADCY2(12), ADCY3(5), ADCY4(5), ADCY5(11), ADCY6(10), ADCY7(13), ADCY8(21), ADCY9(8), ADK(2), ADSL(3), ADSS(4), ADSSL1(7), AK1(1), AK5(3), AK7(3), ALLC(5), AMPD1(8), AMPD2(7), AMPD3(13), APRT(2), ATIC(6), CANT1(3), DGUOK(2), ENPP1(5), ENPP3(4), ENTPD1(5), ENTPD3(4), ENTPD4(7), ENTPD6(2), ENTPD8(6), GART(8), GDA(2), GMPR(1), GMPR2(2), GMPS(4), GUCY1A2(8), GUCY1A3(14), GUCY1B3(7), GUCY2C(7), GUCY2D(12), GUCY2F(13), GUK1(3), IMPDH1(5), IMPDH2(3), NME6(2), NME7(1), NPR1(9), NPR2(7), NT5C(1), NT5C1A(4), NT5C1B(5), NT5C2(7), NT5C3(1), NUDT2(3), NUDT5(1), NUDT9(1), PAICS(1), PAPSS1(4), PAPSS2(4), PDE10A(7), PDE11A(6), PDE1A(6), PDE1C(5), PDE2A(8), PDE3B(13), PDE4A(7), PDE4B(4), PDE4C(4), PDE4D(1), PDE5A(6), PDE6G(1), PDE7A(4), PDE7B(2), PDE8A(8), PDE8B(4), PDE9A(4), PFAS(5), PKLR(5), PKM2(5), PNPT1(4), POLA1(5), POLA2(3), POLD1(10), POLD2(1), POLD3(3), POLE(17), POLE2(3), POLE3(1), POLR1A(12), POLR1B(4), POLR1C(2), POLR1D(1), POLR2A(15), POLR2B(9), POLR2C(2), POLR2E(2), POLR2F(1), POLR2G(1), POLR2I(1), POLR2K(1), POLR3A(15), POLR3B(7), POLR3G(2), POLR3K(1), PPAT(3), PRIM1(2), PRIM2(6), PRPS1(2), PRPS1L1(2), PRPS2(2), PRUNE(3), RFC5(1), RRM1(5), RRM2(3), RRM2B(4), XDH(11) 53568441 621 139 615 241 214 180 24 153 50 0 0.455 1.000 1.000 253 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(6), ACTN2(22), ACTN3(2), ACTN4(6), ARHGAP5(11), BCAR1(4), CD99(1), CDC42(1), CDH5(5), CLDN1(2), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(4), CLDN18(2), CLDN19(3), CLDN20(3), CLDN22(2), CLDN23(2), CLDN3(1), CLDN4(5), CLDN5(2), CLDN6(4), CLDN8(1), CLDN9(3), CTNNA1(11), CTNNA2(16), CTNNA3(9), CTNNB1(16), CTNND1(13), CXCR4(1), CYBB(6), ESAM(5), EZR(3), F11R(2), GNAI1(1), GNAI2(2), GNAI3(6), GRLF1(15), ICAM1(1), ITGA4(9), ITGAL(11), ITGAM(6), ITGB1(6), ITGB2(5), ITK(5), JAM2(2), JAM3(4), MAPK11(1), MAPK13(1), MAPK14(1), MLLT4(18), MMP2(3), MMP9(13), MSN(9), MYL2(6), MYL7(1), MYL9(2), NCF1(3), NCF2(2), NOX1(4), NOX3(3), OCLN(4), PIK3CA(62), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PLCG1(16), PLCG2(11), PRKCA(3), PRKCG(13), PTK2(10), PTK2B(10), PTPN11(5), PXN(3), RAC2(2), RAP1A(2), RAP1B(5), RAPGEF3(2), RAPGEF4(7), RASSF5(2), RHOA(14), RHOH(2), ROCK1(9), ROCK2(7), SIPA1(1), THY1(1), TXK(2), VASP(2), VAV1(6), VAV2(11), VAV3(10), VCAM1(8), VCL(1) 40740408 615 139 570 215 208 186 25 121 73 2 0.0490 1.000 1.000 254 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(3), AKT2(6), AKT3(6), BCL10(1), CARD11(15), CBL(2), CBLB(3), CBLC(2), CD247(3), CD3E(2), CD4(5), CD40LG(4), CD8A(4), CD8B(2), CDC42(1), CTLA4(3), FOS(1), FYN(8), GRAP2(4), GRB2(4), ICOS(1), IFNG(2), IKBKB(7), IL10(2), IL4(1), ITK(5), JUN(3), KRAS(25), LAT(2), LCK(3), LCP2(5), MALT1(4), MAP3K14(3), NCK1(6), NCK2(3), NFAT5(9), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(12), NFKB1(7), NFKB2(2), NFKBIA(1), NFKBIB(5), NRAS(2), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PAK7(7), PDCD1(2), PDK1(2), PIK3CA(62), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PLCG1(16), PPP3CA(5), PPP3CB(6), PPP3CC(3), PPP3R2(3), PRKCQ(7), PTPN6(3), PTPRC(15), RASGRP1(5), RHOA(14), SOS1(6), SOS2(11), TEC(4), TNF(1), VAV1(6), VAV2(11), VAV3(10), ZAP70(10) 33317155 512 138 450 147 153 180 19 111 49 0 0.000294 1.000 1.000 255 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(8), BRAF(9), C7orf16(3), CACNA1A(16), CRHR1(10), GNA11(5), GNA12(1), GNA13(3), GNAI1(1), GNAI2(2), GNAI3(6), GNAQ(3), GNAS(20), GNAZ(11), GRIA1(17), GRIA2(17), GRIA3(6), GRID2(14), GRM1(26), GRM5(23), GUCY1A2(8), GUCY1A3(14), GUCY1B3(7), GUCY2C(7), GUCY2D(12), GUCY2F(13), IGF1(4), IGF1R(15), ITPR1(21), ITPR2(20), ITPR3(30), KRAS(25), LYN(4), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK3(1), NOS1(22), NOS3(5), NPR1(9), NPR2(7), NRAS(2), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(1), PLA2G2D(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), PPP2CA(3), PPP2CB(2), PPP2R1A(9), PPP2R1B(4), PPP2R2A(5), PPP2R2B(5), PPP2R2C(5), PRKCA(3), PRKCG(13), PRKG1(8), PRKG2(10), RAF1(7), RYR1(43) 36143687 616 138 585 189 226 164 25 159 41 1 0.00195 1.000 1.000 256 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(16), ADCY2(12), ADCY3(5), ADCY4(5), ADCY5(11), ADCY6(10), ADCY7(13), ADCY8(21), ADCY9(8), AKAP1(2), AKAP10(3), AKAP11(9), AKAP12(9), AKAP3(8), AKAP4(10), AKAP5(2), AKAP6(18), AKAP7(2), AKAP8(9), AKAP9(28), ARHGEF1(9), CALM1(1), CALM2(3), CHMP1B(1), GNA11(5), GNA12(1), GNA13(3), GNA14(3), GNA15(3), GNAI2(2), GNAI3(6), GNAL(2), GNAQ(3), GNAZ(11), GNB2(4), GNG12(1), GNG13(2), GNG7(3), GNGT1(3), GNGT2(2), ITPR1(21), KCNJ3(9), KRAS(25), NRAS(2), PDE1A(6), PDE1B(3), PDE1C(5), PDE4A(7), PDE4B(4), PDE4C(4), PDE4D(1), PDE7A(4), PDE7B(2), PDE8A(8), PDE8B(4), PLCB3(8), PPP3CA(5), PPP3CC(3), PRKACA(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKCA(3), PRKCD(7), PRKCE(8), PRKCG(13), PRKCH(6), PRKCI(4), PRKCQ(7), PRKD1(16), PRKD3(4), RHOA(14), RRAS(1), SLC9A1(8), USP5(4) 38361551 510 136 479 182 149 168 21 120 51 1 0.0747 1.000 1.000 257 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(4), ACTN1(6), ACTR2(2), ACTR3(2), AKT1(3), AKT2(6), AKT3(6), ANGPTL2(3), ARHGEF6(12), ARHGEF7(7), BCAR1(4), BRAF(9), CAV1(4), CDC42(1), CDKN2A(6), CRK(1), CSE1L(2), DOCK1(15), EPHB2(8), FYN(8), GRB2(4), GRB7(7), GRLF1(15), ILK(3), ITGA1(7), ITGA10(5), ITGA11(7), ITGA2(5), ITGA3(7), ITGA4(9), ITGA5(4), ITGA6(4), ITGA7(7), ITGA8(5), ITGA9(7), ITGB3BP(1), MAP2K4(7), MAP2K7(20), MAP3K11(7), MAPK1(2), MAPK10(5), MAPK8(5), MAPK8IP1(2), MAPK8IP2(3), MAPK8IP3(10), MAPK9(4), MYLK(15), MYLK2(2), P4HB(2), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PAK7(7), PIK3CA(62), PIK3CB(7), PKLR(5), PLCG1(16), PLCG2(11), PTEN(18), PTK2(10), RAF1(7), RHO(6), ROCK1(9), ROCK2(7), SHC1(3), SOS1(6), SOS2(11), SRC(2), TERF2IP(4), TLN1(14), TLN2(21), VASP(2), WAS(1), ZYX(5) 40143554 550 135 511 167 183 164 21 112 69 1 0.00361 1.000 1.000 258 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(8), BID(2), BRAF(9), CASP3(2), CD244(2), CD247(3), FAS(3), FASLG(2), FCGR3A(3), FCGR3B(3), FYN(8), GRB2(4), GZMB(2), HCST(1), HLA-A(6), HLA-B(12), HLA-C(3), HLA-E(3), HLA-G(3), ICAM1(1), ICAM2(2), IFNA1(1), IFNA10(5), IFNA13(1), IFNA16(2), IFNA17(4), IFNA2(1), IFNA21(1), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(4), IFNA8(1), IFNAR1(5), IFNAR2(6), IFNB1(2), IFNG(2), IFNGR1(5), IFNGR2(1), ITGAL(11), ITGB2(5), KIR2DL1(5), KIR2DL3(2), KIR2DL4(3), KIR3DL1(5), KIR3DL2(1), KLRC1(3), KLRC2(2), KLRC3(4), KLRD1(4), KRAS(25), LAT(2), LCK(3), LCP2(5), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK3(1), MICA(1), MICB(2), NCR1(3), NCR2(4), NCR3(1), NFAT5(9), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(12), NRAS(2), PAK1(5), PIK3CA(62), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PLCG1(16), PLCG2(11), PPP3CA(5), PPP3CB(6), PPP3CC(3), PPP3R2(3), PRF1(1), PRKCA(3), PRKCG(13), PTK2B(10), PTPN11(5), PTPN6(3), RAC2(2), RAC3(3), RAF1(7), SH2D1A(1), SH2D1B(1), SH3BP2(3), SHC1(3), SHC2(2), SHC3(8), SHC4(1), SOS1(6), SOS2(11), SYK(6), TNF(1), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10C(1), TNFRSF10D(3), TNFSF10(3), ULBP1(2), ULBP3(1), VAV1(6), VAV2(11), VAV3(10), ZAP70(10) 37204437 591 134 529 161 169 200 20 134 67 1 4.40e-06 1.000 1.000 259 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT1(3), AKT2(6), AKT3(6), BAD(3), CDC42(1), CDK2(3), CDKN2A(6), CREB1(3), CREB3(4), CREB5(4), EBP(1), ERBB4(33), F2RL2(2), GAB1(2), GRB2(4), GSK3A(2), GSK3B(4), IGF1(4), IGFBP1(5), INPPL1(14), IRS1(15), IRS2(4), IRS4(16), MET(7), MYC(3), NOLC1(6), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PAK7(7), PARD3(9), PARD6A(1), PDK1(2), PIK3CA(62), PIK3CD(10), PPP1R13B(6), PREX1(13), PTEN(18), PTK2(10), PTPN1(2), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3), RPS6KB1(4), SHC1(3), SLC2A4(4), SOS1(6), SOS2(11), TSC1(3), TSC2(7), YWHAB(1), YWHAE(1), YWHAG(1), YWHAH(3), YWHAQ(2), YWHAZ(2) 25378435 392 134 354 107 121 128 18 73 52 0 0.000296 1.000 1.000 260 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(16), ADCY8(21), ARAF(8), BRAF(9), CACNA1C(27), CALM1(1), CALM2(3), CALML3(1), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CAMK4(6), CREBBP(26), EP300(19), GNAQ(3), GRIA1(17), GRIA2(17), GRIN1(4), GRIN2A(11), GRIN2B(18), GRIN2C(4), GRIN2D(4), GRM1(26), GRM5(23), ITPR1(21), ITPR2(20), ITPR3(30), KRAS(25), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK3(1), NRAS(2), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), PPP1CA(2), PPP1CB(1), PPP1CC(4), PPP1R12A(2), PPP1R1A(1), PPP3CA(5), PPP3CB(6), PPP3CC(3), PPP3R2(3), PRKACA(3), PRKACB(2), PRKACG(5), PRKCA(3), PRKCG(13), PRKX(4), RAF1(7), RAP1A(2), RAP1B(5), RAPGEF3(2), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3), RPS6KA6(15) 32646703 523 133 491 181 179 156 12 115 60 1 0.0346 1.000 1.000 261 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM1(1), CALM2(3), CALML3(1), CDIPT(1), CDS1(4), CDS2(2), DGKA(4), DGKB(10), DGKD(2), DGKE(7), DGKG(1), DGKH(7), DGKI(9), DGKZ(4), FN3K(2), IMPA1(3), IMPA2(1), INPP4A(3), INPP4B(5), INPP5A(5), INPP5B(7), INPP5D(1), INPP5E(6), INPPL1(14), ITGB1BP3(2), ITPK1(4), ITPKA(1), ITPKB(7), ITPR1(21), ITPR2(20), ITPR3(30), OCRL(8), PI4KA(11), PI4KB(3), PIK3C2A(8), PIK3C2B(15), PIK3C2G(7), PIK3C3(10), PIK3CA(62), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PIP4K2A(4), PIP4K2B(2), PIP4K2C(1), PIP5K1A(3), PIP5K1B(1), PIP5K1C(8), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), PLCD1(4), PLCD3(8), PLCD4(2), PLCE1(11), PLCG1(16), PLCG2(11), PLCZ1(3), PRKCA(3), PRKCG(13), PTEN(18), PTPMT1(1), SYNJ1(7), SYNJ2(9) 40858728 530 132 485 161 181 170 18 108 51 2 0.000853 1.000 1.000 262 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(5), ACVR1B(12), ACVRL1(3), AKT1(3), AURKB(4), BMPR1A(3), BMPR2(11), BUB1(10), CDIPT(1), CDKL1(2), CDKL2(3), CDS1(4), CDS2(2), CLK1(3), CLK2(8), CLK4(2), COL4A3BP(3), CSNK2A1(7), CSNK2A2(4), CSNK2B(1), DGKA(4), DGKB(10), DGKD(2), DGKE(7), DGKG(1), DGKH(7), DGKZ(4), IMPA1(3), INPP4A(3), INPP4B(5), INPP5A(5), INPPL1(14), ITPKA(1), ITPKB(7), MAP3K10(8), MOS(9), NEK1(2), NEK3(1), OCRL(8), PAK4(6), PIK3C2A(8), PIK3C2B(15), PIK3C2G(7), PIK3CA(62), PIK3CB(7), PIK3CG(15), PIM2(2), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), PLCD1(4), PLCG1(16), PLCG2(11), PLK3(4), PRKACA(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKCA(3), PRKCD(7), PRKCE(8), PRKCG(13), PRKCH(6), PRKCQ(7), PRKD1(16), PRKG1(8), RAF1(7), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3), RPS6KA4(1), RPS6KB1(4), STK11(2), TGFBR1(5), VRK1(1) 37013644 513 132 467 156 151 170 23 112 54 3 0.00601 1.000 1.000 263 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(5), ACVR1B(12), ACVR1C(3), ACVR2A(6), ACVR2B(3), ACVRL1(3), AMHR2(2), BMP2(2), BMP4(4), BMP5(9), BMP6(6), BMP7(5), BMP8A(1), BMP8B(2), BMPR1A(3), BMPR1B(4), BMPR2(11), CHRD(6), COMP(2), CREBBP(26), CUL1(14), DCN(5), E2F4(1), E2F5(1), EP300(19), FST(2), GDF5(7), GDF6(11), GDF7(2), ID3(1), IFNG(2), INHBA(7), INHBB(8), INHBC(3), INHBE(1), LEFTY1(2), LEFTY2(1), LTBP1(15), MAPK1(2), MAPK3(1), MYC(3), PITX2(4), PPP2CA(3), PPP2CB(2), PPP2R1A(9), PPP2R1B(4), PPP2R2A(5), PPP2R2B(5), PPP2R2C(5), RBL1(7), RBL2(4), RBX1(1), RHOA(14), ROCK1(9), ROCK2(7), RPS6KB1(4), RPS6KB2(3), SMAD1(2), SMAD2(8), SMAD3(3), SMAD4(21), SMAD5(2), SMAD6(5), SMAD7(3), SMAD9(8), SMURF1(3), SMURF2(3), SP1(6), TFDP1(3), TGFB1(3), TGFB2(6), TGFB3(5), TGFBR1(5), TGFBR2(11), THBS1(12), THBS2(7), THBS3(6), THBS4(10), TNF(1), ZFYVE16(7), ZFYVE9(5) 32418520 454 131 439 173 153 127 22 87 61 4 0.349 1.000 1.000 264 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(3), AKT2(6), AKT3(6), CASP8(8), CCL5(1), CD14(2), CD40(1), CD80(1), CD86(2), CXCL10(1), CXCL9(2), FOS(1), IFNA1(1), IFNA10(5), IFNA13(1), IFNA16(2), IFNA17(4), IFNA2(1), IFNA21(1), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(4), IFNA8(1), IFNAR1(5), IFNAR2(6), IFNB1(2), IKBKB(7), IKBKE(8), IL12A(2), IL12B(1), IL1B(2), IL8(1), IRAK1(5), IRAK4(2), IRF5(3), IRF7(1), JUN(3), LBP(1), LY96(1), MAP2K1(5), MAP2K2(2), MAP2K3(7), MAP2K4(7), MAP2K6(1), MAP2K7(20), MAP3K7(8), MAPK1(2), MAPK10(5), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(5), MAPK9(4), MYD88(1), NFKB1(7), NFKB2(2), NFKBIA(1), PIK3CA(62), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), RELA(3), RIPK1(1), SPP1(3), STAT1(7), TBK1(5), TICAM1(9), TIRAP(1), TLR1(5), TLR2(1), TLR3(5), TLR4(18), TLR5(8), TLR6(1), TLR7(5), TLR8(10), TLR9(13), TNF(1), TOLLIP(2), TRAF3(3), TRAF6(5) 29406445 417 131 373 126 123 129 20 100 45 0 0.00544 1.000 1.000 265 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(16), ADCY2(12), ADCY3(5), ADCY4(5), ADCY5(11), ADCY6(10), ADCY7(13), ADCY8(21), ADCY9(8), CACNA1C(27), CACNA1D(21), CACNA1F(9), CACNA1S(11), CALM1(1), CALM2(3), CALML3(1), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CDC42(1), CGA(1), EGFR(11), ELK1(3), FSHB(1), GNA11(5), GNAQ(3), GNAS(20), GNRH1(1), GNRH2(2), GNRHR(4), GRB2(4), HBEGF(2), ITPR1(21), ITPR2(20), ITPR3(30), JUN(3), KRAS(25), MAP2K1(5), MAP2K2(2), MAP2K3(7), MAP2K4(7), MAP2K6(1), MAP2K7(20), MAP3K1(9), MAP3K2(3), MAP3K3(4), MAP3K4(15), MAPK1(2), MAPK10(5), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(7), MAPK8(5), MAPK9(4), MMP2(3), NRAS(2), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(1), PLA2G2D(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), PLD1(13), PLD2(13), PRKACA(3), PRKACB(2), PRKACG(5), PRKCA(3), PRKCD(7), PRKX(4), PTK2B(10), RAF1(7), SOS1(6), SOS2(11), SRC(2) 41727961 597 130 569 211 223 168 22 124 59 1 0.0497 1.000 1.000 266 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(16), ADCY2(12), ADCY3(5), ADCY4(5), ADCY5(11), ADCY6(10), ADCY7(13), ADCY8(21), ADCY9(8), ASIP(1), CALM1(1), CALM2(3), CALML3(1), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CREB1(3), CREB3(4), CREB3L1(3), CREB3L2(3), CREB3L3(3), CREB3L4(1), CREBBP(26), CTNNB1(16), DCT(8), DVL1(4), DVL2(3), DVL3(8), EDN1(2), EDNRB(20), EP300(19), FZD1(7), FZD10(14), FZD2(7), FZD3(5), FZD4(4), FZD5(3), FZD6(5), FZD7(4), FZD8(6), FZD9(2), GNAI1(1), GNAI2(2), GNAI3(6), GNAQ(3), GNAS(20), GSK3B(4), KIT(12), KITLG(2), KRAS(25), LEF1(5), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK3(1), MITF(8), NRAS(2), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), POMC(6), PRKACA(3), PRKACB(2), PRKACG(5), PRKCA(3), PRKCG(13), PRKX(4), RAF1(7), TCF7(3), TCF7L1(3), TCF7L2(8), TYR(6), TYRP1(3), WNT1(5), WNT10A(4), WNT10B(1), WNT11(2), WNT16(5), WNT2(4), WNT2B(7), WNT3(5), WNT3A(4), WNT4(1), WNT5A(4), WNT5B(3), WNT6(2), WNT7A(3), WNT7B(6), WNT8A(1), WNT8B(1), WNT9A(3), WNT9B(3) 35647366 563 125 532 210 213 167 16 115 51 1 0.0557 1.000 1.000 267 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(6), ADCY1(16), ADCY2(12), ADCY3(5), ADCY4(5), ADCY5(11), ADCY6(10), ADCY7(13), ADCY8(21), ADK(2), ADSL(3), ADSS(4), AK1(1), AK5(3), ALLC(5), AMPD1(8), AMPD2(7), AMPD3(13), APRT(2), ATIC(6), ATP1B1(1), ATP5A1(2), ATP5B(3), ATP5C1(3), ATP5F1(1), ATP5G2(1), ATP5J(1), ATP5J2(1), CANT1(3), DGUOK(2), ENPP1(5), ENPP3(4), ENTPD1(5), GART(8), GDA(2), GMPS(4), GUCY1A2(8), GUCY1A3(14), GUCY1B3(7), GUCY2C(7), GUCY2D(12), GUCY2F(13), GUK1(3), IMPDH1(5), IMPDH2(3), NPR1(9), NPR2(7), NT5C(1), NUDT2(3), PAICS(1), PAPSS1(4), PAPSS2(4), PDE1A(6), PDE4A(7), PDE4B(4), PDE4C(4), PDE4D(1), PDE5A(6), PDE6B(8), PDE6C(3), PDE6G(1), PDE7B(2), PDE8A(8), PDE9A(4), PFAS(5), PKLR(5), PKM2(5), POLB(2), POLD1(10), POLD2(1), POLE(17), POLG(5), POLL(2), POLQ(22), POLR1B(4), POLR2A(15), POLR2B(9), POLR2C(2), POLR2E(2), POLR2F(1), POLR2G(1), POLR2I(1), POLR2K(1), POLRMT(10), PPAT(3), PRPS1(2), PRPS1L1(2), PRPS2(2), PRUNE(3), RRM1(5), RRM2(3) 42009235 494 124 489 193 159 149 21 127 38 0 0.503 1.000 1.000 268 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(3), AKT3(6), BCAR1(4), CAPN1(2), CAPN10(3), CAPN11(2), CAPN2(3), CAPN3(9), CAPN5(3), CAPN6(5), CAPN7(5), CAPN9(2), CAPNS1(2), CAV1(4), CAV2(2), CAV3(2), CDC42(1), CRK(1), CSK(5), DOCK1(15), FYN(8), GIT2(1), GRB2(4), ILK(3), ITGA10(5), ITGA11(7), ITGA2(5), ITGA2B(7), ITGA3(7), ITGA4(9), ITGA5(4), ITGA6(4), ITGA7(7), ITGA8(5), ITGA9(7), ITGAD(9), ITGAE(6), ITGAL(11), ITGAM(6), ITGAV(5), ITGAX(8), ITGB1(6), ITGB2(5), ITGB3(3), ITGB4(12), ITGB5(5), ITGB6(3), ITGB7(4), ITGB8(8), MAP2K1(5), MAP2K2(2), MAP2K3(7), MAP2K6(1), MAPK10(5), MAPK4(6), MAPK6(1), MAPK7(7), MYLK2(2), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PDPK1(2), PIK3R2(8), PTK2(10), PXN(3), RAC2(2), RAC3(3), RAP1B(5), RAPGEF1(9), RHO(6), ROCK1(9), ROCK2(7), SDCCAG8(3), SHC1(3), SHC3(8), SORBS1(7), SOS1(6), SRC(2), TLN1(14), TNS1(22), VASP(2), VAV2(11), VAV3(10), VCL(1), ZYX(5) 43935585 473 121 466 197 165 120 24 107 56 1 0.759 1.000 1.000 269 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(16), BDKRB1(1), BDKRB2(3), C1QA(1), C1QC(2), C1R(3), C1S(5), C2(2), C3(21), C3AR1(5), C4BPA(1), C4BPB(2), C5(11), C5AR1(5), C6(10), C7(2), C8A(5), C8B(11), C9(6), CD46(2), CD55(2), CFB(5), CFH(12), CFI(9), CPB2(6), CR1(23), CR2(8), F10(6), F11(3), F12(2), F13A1(10), F13B(13), F2(5), F2R(2), F3(1), F5(13), F7(9), F8(15), F9(6), FGA(7), FGB(2), FGG(2), KLKB1(7), KNG1(8), MASP1(3), MASP2(4), MBL2(1), PLAT(4), PLAU(2), PLAUR(3), PLG(11), PROC(2), PROS1(8), SERPINA1(3), SERPINA5(5), SERPINC1(4), SERPIND1(3), SERPINE1(3), SERPINF2(5), SERPING1(5), TFPI(3), THBD(1), VWF(19) 29731419 379 120 372 123 111 104 20 102 41 1 0.0839 1.000 1.000 270 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(3), AKT2(6), AKT3(6), BTK(2), FCER1A(2), FYN(8), GRB2(4), IL13(1), IL3(1), IL4(1), INPP5D(1), KRAS(25), LAT(2), LCP2(5), LYN(4), MAP2K1(5), MAP2K2(2), MAP2K3(7), MAP2K4(7), MAP2K6(1), MAP2K7(20), MAPK1(2), MAPK10(5), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(5), MAPK9(4), MS4A2(1), NRAS(2), PDK1(2), PIK3CA(62), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(1), PLA2G2D(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), PLCG1(16), PLCG2(11), PRKCA(3), PRKCD(7), PRKCE(8), RAC2(2), RAC3(3), RAF1(7), SOS1(6), SOS2(11), SYK(6), TNF(1), VAV1(6), VAV2(11), VAV3(10) 23651357 396 119 339 92 119 145 11 84 37 0 1.14e-06 1.000 1.000 271 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(1), ALG1(5), ALG10(6), ALG10B(3), ALG12(3), ALG13(7), ALG14(1), ALG3(2), ALG6(2), ALG8(1), ALG9(1), B3GNT1(3), B3GNT2(2), B3GNT7(3), B4GALT1(2), B4GALT2(5), B4GALT3(2), B4GALT4(4), B4GALT5(5), B4GALT7(2), C1GALT1(3), C1GALT1C1(4), CHPF(2), CHST1(13), CHST11(2), CHST12(4), CHST13(2), CHST14(2), CHST2(10), CHST3(3), CHST4(4), CHST6(6), CHST7(7), CHSY1(4), DPAGT1(1), EXT1(16), EXT2(5), EXTL1(4), EXTL2(2), EXTL3(10), FUT11(3), FUT8(3), GALNT1(2), GALNT10(5), GALNT11(4), GALNT12(1), GALNT13(7), GALNT14(6), GALNT2(4), GALNT3(2), GALNT4(2), GALNT5(7), GALNT6(2), GALNT8(5), GALNT9(2), GALNTL1(7), GALNTL2(7), GALNTL4(7), GALNTL5(3), GANAB(4), GCNT3(2), GCNT4(2), HS2ST1(2), HS3ST1(2), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(3), HS3ST5(6), HS6ST1(2), HS6ST2(4), HS6ST3(6), MAN1A1(2), MAN1A2(3), MAN1B1(5), MAN1C1(2), MAN2A1(3), MGAT1(2), MGAT2(2), MGAT3(5), MGAT4A(2), MGAT4B(2), MGAT5(8), MGAT5B(4), NDST1(10), NDST2(6), NDST3(10), NDST4(13), OGT(2), RPN1(2), RPN2(3), ST3GAL1(4), ST3GAL2(4), ST3GAL3(1), ST3GAL4(4), ST6GALNAC1(2), STT3B(3), UST(7), WBSCR17(22), XYLT1(8), XYLT2(7) 36078086 434 118 426 175 164 119 20 92 38 1 0.595 1.000 1.000 272 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(3), AKT2(6), AKT3(6), BAD(3), CASP9(2), CDC42(1), KDR(8), KRAS(25), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPKAPK2(1), MAPKAPK3(4), NFAT5(9), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(12), NOS3(5), NRAS(2), PIK3CA(62), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(1), PLA2G2D(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), PLCG1(16), PLCG2(11), PPP3CA(5), PPP3CB(6), PPP3CC(3), PPP3R2(3), PRKCA(3), PRKCG(13), PTGS2(5), PTK2(10), PXN(3), RAC2(2), RAC3(3), RAF1(7), SH2D2A(5), SHC2(2), SPHK1(4), SPHK2(2), SRC(2) 23579150 384 118 326 88 122 134 14 81 33 0 1.75e-07 1.000 1.000 273 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(2), ACTR3(2), AKT1(3), AKT2(6), AKT3(6), ANGPTL2(3), ARHGAP1(1), ARHGAP4(4), ARHGEF11(12), BTK(2), CDC42(1), CFL1(1), GDI1(2), GDI2(3), INPPL1(14), ITPR1(21), ITPR2(20), ITPR3(30), LIMK1(3), MYLK(15), MYLK2(2), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PAK7(7), PDK1(2), PIK3CA(62), PIK3CD(10), PIK3CG(15), PIK3R1(8), PITX2(4), PPP1R13B(6), PTEN(18), RACGAP1(5), RHO(6), ROCK1(9), ROCK2(7), SAG(2), WASF1(3), WASL(1) 23053812 344 115 304 94 115 112 15 63 37 2 0.000820 1.000 1.000 274 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(34), AXIN1(8), CCND1(1), CCND2(3), CCND3(2), CSNK1E(7), CTNNB1(16), DVL1(4), DVL2(3), DVL3(8), FBXW2(3), FZD1(7), FZD10(14), FZD2(7), FZD3(5), FZD5(3), FZD6(5), FZD7(4), FZD8(6), FZD9(2), GSK3B(4), JUN(3), LDLR(7), MAPK10(5), MAPK9(4), MYC(3), PAFAH1B1(5), PLAU(2), PPP2R5C(6), PPP2R5E(4), PRKCA(3), PRKCD(7), PRKCE(8), PRKCG(13), PRKCH(6), PRKCI(4), PRKCQ(7), PRKD1(16), RHOA(14), SFRP4(3), TCF7(3), WNT1(5), WNT10A(4), WNT10B(1), WNT11(2), WNT16(5), WNT2(4), WNT2B(7), WNT3(5), WNT4(1), WNT5A(4), WNT5B(3), WNT6(2), WNT7A(3), WNT7B(6) 19655299 321 114 310 106 110 73 15 71 48 4 0.0363 1.000 1.000 275 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(28), ASH2L(4), C17orf79(1), CARM1(2), CTCFL(7), DOT1L(8), EHMT1(10), EHMT2(6), EZH1(4), EZH2(5), FBXO11(9), HCFC1(15), HSF4(4), JMJD4(1), JMJD6(2), KDM6A(9), MEN1(6), MLL(22), MLL2(45), MLL3(53), MLL4(26), MLL5(15), NSD1(16), OGT(2), PAXIP1(4), PPP1CA(2), PPP1CB(1), PPP1CC(4), PRDM2(22), PRDM9(15), PRMT1(2), PRMT5(2), PRMT6(2), PRMT7(4), PRMT8(3), RBBP5(1), SATB1(11), SETD1A(9), SETD2(11), SETD7(1), SETDB1(13), SETDB2(6), SMYD3(3), STK38(4), SUV39H1(5), SUV39H2(2), SUV420H1(9), SUV420H2(3), SUZ12(3), WHSC1(12), WHSC1L1(9) 38964491 463 113 458 158 144 128 13 96 74 8 0.268 1.000 1.000 276 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(4), ALG6(2), CCKBR(6), CCR2(5), CCR3(6), CCR5(3), CELSR1(23), CELSR2(17), CELSR3(30), CHRM2(13), CHRM3(9), CIDEB(2), DRD4(2), EDNRA(3), EMR2(9), EMR3(4), F2R(2), FSHR(18), GHRHR(4), GNRHR(4), GPR116(11), GPR132(2), GPR133(9), GPR135(7), GPR143(4), GPR17(1), GPR18(2), GPR55(7), GPR56(4), GPR61(6), GPR77(1), GPR84(1), GRM1(26), GRPR(7), HRH4(3), LGR6(10), LPHN2(17), LPHN3(14), LTB4R2(2), NTSR1(5), OR2M4(5), OR8G2(5), P2RY13(2), PTGFR(3), SMO(10), SSTR2(3), TAAR5(5), TSHR(8), VN1R1(2) 21821689 348 113 344 124 113 96 18 99 22 0 0.0938 1.000 1.000 277 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(13), AMY2A(3), AMY2B(13), ASCC3(24), ATP13A2(10), DDX18(8), DDX19A(4), DDX23(7), DDX4(4), DDX41(7), DDX47(2), DDX50(6), DDX51(2), DDX52(1), DDX54(13), DDX55(3), DDX56(4), DHX58(7), ENPP1(5), ENPP3(4), ENTPD7(9), EP400(25), ERCC2(5), ERCC3(7), G6PC2(1), GAA(2), GANC(7), GBA(6), GBA3(1), GBE1(3), GCK(4), GPI(5), GUSB(8), GYS1(3), GYS2(4), HK1(11), HK2(8), HK3(5), IFIH1(5), LYZL1(4), MGAM(9), MOV10L1(3), NUDT5(1), PGM1(2), PGM3(10), PYGB(8), PYGL(6), PYGM(9), RAD54B(3), RAD54L(4), RUVBL2(2), SETX(12), SI(19), SKIV2L2(7), SMARCA2(16), SMARCA5(3), TREH(3), UGDH(5), UGP2(3), UGT1A1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A5(8), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2A1(3), UGT2A3(3), UGT2B10(8), UGT2B11(2), UGT2B15(2), UGT2B28(5), UGT2B4(3), UGT2B7(3), UXS1(3) 40574683 439 112 439 155 134 140 14 108 43 0 0.189 1.000 1.000 278 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(3), AKT2(6), AKT3(6), BCL10(1), BLNK(3), BTK(2), CARD11(15), CD19(3), CD22(3), CD72(1), CD79A(6), CD79B(1), CD81(3), CR2(8), FCGR2B(3), FOS(1), GSK3B(4), IFITM1(3), IKBKB(7), INPP5D(1), JUN(3), KRAS(25), LILRB3(3), LYN(4), MALT1(4), NFAT5(9), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(12), NFKB1(7), NFKB2(2), NFKBIA(1), NFKBIB(5), NRAS(2), PIK3CA(62), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PLCG2(11), PPP3CA(5), PPP3CB(6), PPP3CC(3), PPP3R2(3), PTPN6(3), RAC2(2), RAC3(3), RASGRP3(4), SYK(6), VAV1(6), VAV2(11), VAV3(10) 24449262 380 112 326 105 119 141 10 75 35 0 9.95e-05 1.000 1.000 279 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(13), ABCA10(14), ABCA12(25), ABCA13(37), ABCA2(13), ABCA3(14), ABCA4(13), ABCA5(12), ABCA6(7), ABCA7(6), ABCA8(10), ABCA9(12), ABCB1(18), ABCB10(11), ABCB11(8), ABCB4(17), ABCB5(9), ABCB6(4), ABCB7(2), ABCB8(4), ABCB9(3), ABCC1(9), ABCC10(5), ABCC11(14), ABCC12(14), ABCC2(11), ABCC3(8), ABCC4(11), ABCC5(8), ABCC6(9), ABCC8(13), ABCC9(30), ABCD1(6), ABCD2(2), ABCD3(4), ABCD4(6), ABCG1(7), ABCG2(3), ABCG4(4), ABCG8(5), CFTR(8), TAP1(2), TAP2(10) 38721408 441 110 434 167 130 143 16 105 46 1 0.219 1.000 1.000 280 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(3), AKT2(6), AKT3(6), BRD4(9), CAP1(3), CBL(2), CDC42(1), CDKN2A(6), F2RL2(2), FLOT1(2), FLOT2(3), GRB2(4), GSK3A(2), GSK3B(4), IGFBP1(5), INPPL1(14), IRS1(15), IRS2(4), IRS4(16), LNPEP(8), MAPK1(2), MAPK3(1), PARD3(9), PARD6A(1), PDK1(2), PIK3CA(62), PIK3CD(10), PIK3R1(8), PPYR1(6), PTEN(18), PTPN1(2), RAF1(7), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3), RPS6KB1(4), SERPINB6(3), SHC1(3), SLC2A4(4), SORBS1(7), SOS1(6), SOS2(11), YWHAB(1), YWHAE(1), YWHAG(1), YWHAH(3), YWHAQ(2), YWHAZ(2) 19513883 308 110 271 84 105 102 6 54 41 0 0.00169 1.000 1.000 281 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(7), BAD(3), BCL2(2), CABIN1(13), CALM1(1), CALM2(3), CAMK2B(2), CAMK4(6), CD3E(2), CDKN1A(1), CNR1(7), CREBBP(26), CSNK2A1(7), CSNK2B(1), CTLA4(3), EGR2(6), EGR3(5), EP300(19), FCER1A(2), FCGR3A(3), FOS(1), GATA3(8), GATA4(4), GRLF1(15), GSK3A(2), GSK3B(4), ICOS(1), IFNA1(1), IFNB1(2), IFNG(2), IL10(2), IL13(1), IL1B(2), IL2RA(2), IL3(1), IL4(1), IL8(1), ITK(5), JUNB(1), KPNA5(4), MAP2K7(20), MAPK14(1), MAPK8(5), MAPK9(4), MEF2B(4), MEF2D(6), MYF5(3), NCK2(3), NFAT5(9), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(12), NFKB2(2), NFKBIB(5), NPPB(2), NUP214(15), OPRD1(1), P2RX7(1), PAK1(5), PIN1(1), PPP3CB(6), PPP3CC(3), PTPRC(15), RELA(3), RPL13A(2), SLA(2), SP1(6), SP3(3), TGFB1(3), TNF(1), TRAF2(2), TRPV6(6), VAV1(6), VAV2(11), VAV3(10), XPO5(3) 29875702 389 109 385 142 133 118 12 81 45 0 0.163 1.000 1.000 282 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(4), ACTB(7), ARHGEF2(10), CD14(2), CDC42(1), CDH1(19), CLDN1(2), CTNNB1(16), CTTN(5), EZR(3), FYN(8), HCLS1(3), ITGB1(6), KRT18(2), LY96(1), NCK1(6), NCK2(3), NCL(6), OCLN(4), PRKCA(3), RHOA(14), ROCK1(9), ROCK2(7), TLR4(18), TLR5(8), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3C(5), TUBA3D(4), TUBA3E(9), TUBA4A(1), TUBA8(4), TUBAL3(4), TUBB1(3), TUBB2A(2), TUBB2B(1), TUBB2C(3), TUBB3(12), TUBB4(4), TUBB4Q(4), TUBB6(7), TUBB8(3), WAS(1), WASL(1), YWHAQ(2), YWHAZ(2) 17253915 243 109 231 74 71 75 7 69 20 1 0.0250 1.000 1.000 283 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(4), ACTB(7), ARHGEF2(10), CD14(2), CDC42(1), CDH1(19), CLDN1(2), CTNNB1(16), CTTN(5), EZR(3), FYN(8), HCLS1(3), ITGB1(6), KRT18(2), LY96(1), NCK1(6), NCK2(3), NCL(6), OCLN(4), PRKCA(3), RHOA(14), ROCK1(9), ROCK2(7), TLR4(18), TLR5(8), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3C(5), TUBA3D(4), TUBA3E(9), TUBA4A(1), TUBA8(4), TUBAL3(4), TUBB1(3), TUBB2A(2), TUBB2B(1), TUBB2C(3), TUBB3(12), TUBB4(4), TUBB4Q(4), TUBB6(7), TUBB8(3), WAS(1), WASL(1), YWHAQ(2), YWHAZ(2) 17253915 243 109 231 74 71 75 7 69 20 1 0.0250 1.000 1.000 284 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(3), AKT2(6), AKT3(6), BCR(9), BTK(2), CD19(3), CDKN2A(6), DAPP1(1), FLOT1(2), FLOT2(3), GAB1(2), ITPR1(21), ITPR2(20), ITPR3(30), LYN(4), NR0B2(2), PDK1(2), PHF11(4), PIK3CA(62), PITX2(4), PLCG2(11), PPP1R13B(6), PREX1(13), PTEN(18), PTPRC(15), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3), RPS6KB1(4), SAG(2), SYK(6), TEC(4), VAV1(6) 18153038 294 109 258 90 93 95 8 66 31 1 0.0259 1.000 1.000 285 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(2), AGT(3), AKT1(3), CALM1(1), CALM2(3), CALR(3), CAMK1(2), CAMK1G(3), CAMK4(6), CREBBP(26), CSNK1A1(3), EDN1(2), ELSPBP1(1), F2(5), FGF2(2), FKBP1A(2), GATA4(4), GSK3B(4), HAND1(2), HAND2(1), IGF1(4), LIF(1), MAP2K1(5), MAPK1(2), MAPK14(1), MAPK3(1), MAPK8(5), MEF2C(3), MYH2(23), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(12), NKX2-5(3), NPPA(1), PIK3CA(62), PIK3R1(8), PPP3CA(5), PPP3CB(6), PPP3CC(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), RAF1(7), RPS6KB1(4), SYT1(3) 16629449 288 108 254 78 94 99 11 53 31 0 0.000287 1.000 1.000 286 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(3), AKT2(6), AKT3(6), BAD(3), BCL2(2), BCR(9), BLNK(3), BTK(2), CD19(3), CD22(3), CD81(3), CR2(8), CSK(5), DAG1(8), FLOT1(2), FLOT2(3), GRB2(4), GSK3A(2), GSK3B(4), INPP5D(1), ITPR1(21), ITPR2(20), ITPR3(30), LYN(4), MAP4K1(3), MAPK1(2), MAPK3(1), NFATC1(11), NFATC2(14), NR0B2(2), PDK1(2), PIK3CA(62), PIK3CD(10), PIK3R1(8), PLCG2(11), PPP1R13B(6), PPP3CA(5), PPP3CB(6), PPP3CC(3), PTPRC(15), RAF1(7), SHC1(3), SOS1(6), SOS2(11), SYK(6), VAV1(6) 24314716 355 108 318 102 121 111 10 78 34 1 0.00139 1.000 1.000 287 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 FN3K(2), IMPA1(3), IMPA2(1), INPP4A(3), INPP4B(5), INPP5A(5), INPP5B(7), INPP5E(6), INPPL1(14), IPMK(1), ISYNA1(2), ITGB1BP3(2), ITPK1(4), ITPKA(1), ITPKB(7), MINPP1(4), MIOX(3), OCRL(8), PI4KA(11), PI4KB(3), PIK3C3(10), PIK3CA(62), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIP4K2A(4), PIP4K2B(2), PIP4K2C(1), PIP5K1A(3), PIP5K1B(1), PIP5K1C(8), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), PLCD1(4), PLCD3(8), PLCD4(2), PLCE1(11), PLCG1(16), PLCG2(11), PLCZ1(3), PTEN(18), PTPMT1(1), SYNJ1(7), SYNJ2(9) 24360203 339 106 297 92 113 120 7 68 31 0 0.000301 1.000 1.000 288 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(9), CPEB1(3), EGFR(11), ERBB2(12), ERBB4(33), ETS1(5), ETS2(3), ETV6(3), ETV7(4), FMN2(23), GRB2(4), KRAS(25), MAP2K1(5), MAPK1(2), MAPK3(1), NOTCH1(19), NOTCH2(19), NOTCH3(16), NOTCH4(11), PIWIL1(5), PIWIL2(5), PIWIL3(2), PIWIL4(4), RAF1(7), SOS1(6), SOS2(11), SPIRE1(4), SPIRE2(2) 17104579 254 106 222 89 83 77 10 65 19 0 0.216 1.000 1.000 289 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(4), APOA1(5), CD36(2), CITED2(3), CPT1B(3), CREBBP(26), DUSP1(2), DUT(1), EHHADH(6), EP300(19), HSD17B4(4), HSPA1A(1), JUN(3), LPL(4), MAPK1(2), MAPK3(1), ME1(1), MYC(3), NCOA1(12), NCOR1(24), NCOR2(21), NFKBIA(1), NR0B2(2), NR1H3(4), NR2F1(3), NRIP1(11), PDGFA(2), PIK3CA(62), PIK3R1(8), PPARA(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKCA(3), PTGS2(5), RB1(6), RELA(3), RXRA(3), SP1(6), SRA1(2), STAT5A(4), STAT5B(6), TNF(1) 20725648 304 106 271 83 78 114 11 66 34 1 0.000719 1.000 1.000 290 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(3), APC(34), AR(11), ASAH1(2), BRAF(9), CAMP(2), CCL15(2), CCL16(1), DAG1(8), EGFR(11), GNA11(5), GNA15(3), GNAI1(1), GNAQ(3), ITPKA(1), ITPKB(7), ITPR1(21), ITPR2(20), ITPR3(30), KCNJ3(9), KCNJ5(3), MAPK1(2), MAPK10(5), MAPK14(1), PHKA2(9), PIK3CA(62), PIK3CD(10), PIK3R1(8), PITX2(4), PTX3(2), RAF1(7), SRC(2) 17514165 298 106 258 84 98 95 14 58 30 3 0.00162 1.000 1.000 291 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(6), CD14(2), CD19(3), CD1A(6), CD1B(5), CD1C(5), CD1D(7), CD1E(7), CD2(2), CD22(3), CD33(7), CD34(3), CD36(2), CD37(2), CD38(3), CD3E(2), CD4(5), CD44(4), CD5(4), CD55(2), CD7(3), CD8A(4), CD8B(2), CD9(1), CR1(23), CR2(8), CSF1(1), CSF1R(7), CSF2RA(8), CSF3(1), CSF3R(6), DNTT(2), EPOR(2), FCER2(1), FLT3(8), GP5(5), GP9(1), GYPA(3), HLA-DRA(6), IL11(2), IL11RA(2), IL1A(2), IL1B(2), IL1R1(4), IL1R2(5), IL2RA(2), IL3(1), IL3RA(5), IL4(1), IL4R(1), IL5RA(4), IL6R(1), IL7(1), IL7R(5), IL9R(3), ITGA1(7), ITGA2(5), ITGA2B(7), ITGA3(7), ITGA4(9), ITGA5(4), ITGA6(4), ITGAM(6), ITGB3(3), KIT(12), KITLG(2), MME(5), MS4A1(1), TFRC(1), THPO(4), TNF(1), TPO(15) 26757339 306 105 296 121 91 77 17 84 37 0 0.577 1.000 1.000 292 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(2), BMP4(4), BMP5(9), BMP6(6), BMP7(5), BMP8A(1), BMP8B(2), BTRC(4), CSNK1A1(3), CSNK1A1L(2), CSNK1D(2), CSNK1E(7), CSNK1G1(2), CSNK1G2(4), CSNK1G3(5), DHH(2), FBXW11(10), GLI1(7), GLI2(11), GLI3(33), GSK3B(4), HHIP(7), IHH(4), LRP2(50), PRKACA(3), PRKACB(2), PRKACG(5), PRKX(4), PTCH1(15), PTCH2(6), RAB23(1), SHH(4), SMO(10), STK36(10), SUFU(5), WNT1(5), WNT10A(4), WNT10B(1), WNT11(2), WNT16(5), WNT2(4), WNT2B(7), WNT3(5), WNT3A(4), WNT4(1), WNT5A(4), WNT5B(3), WNT6(2), WNT7A(3), WNT7B(6), WNT8A(1), WNT8B(1), WNT9A(3), WNT9B(3), ZIC2(2) 19822309 317 103 313 99 124 79 13 72 29 0 0.0125 1.000 1.000 293 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(3), ASAH1(2), BRAF(9), CAMP(2), CREB1(3), CREB3(4), CREB5(4), CREBBP(26), CRKL(1), DAG1(8), EGR1(4), EGR2(6), EGR3(5), EGR4(4), ELK1(3), FRS2(3), GNAQ(3), JUN(3), MAP1B(12), MAP2K4(7), MAP2K7(20), MAPK1(2), MAPK10(5), MAPK3(1), MAPK8(5), MAPK8IP1(2), MAPK8IP2(3), MAPK8IP3(10), MAPK9(4), NTRK1(6), OPN1LW(6), PIK3C2G(7), PIK3CA(62), PIK3CD(10), PIK3R1(8), PTPN11(5), RPS6KA3(3), SHC1(3), SRC(2), TERF2IP(4), TH(2) 16790305 282 103 249 77 92 102 6 50 32 0 0.000277 1.000 1.000 294 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(1), AGTR2(2), ATP8A1(7), AVPR1A(8), AVPR1B(2), AVPR2(4), BDKRB1(1), BDKRB2(3), BRS3(3), C3AR1(5), CCKAR(4), CCKBR(6), CCR1(2), CCR10(2), CCR2(5), CCR3(6), CCR5(3), CCR6(1), CCR7(2), CCR8(1), CX3CR1(3), CXCR4(1), CXCR6(2), EDNRA(3), EDNRB(20), FPR1(4), FSHR(18), GALR1(5), GALR2(9), GALR3(1), GALT(1), GHSR(8), GNB2L1(4), GNRHR(4), GPR77(1), GRPR(7), LHCGR(10), MC2R(2), MC3R(3), MC4R(5), MC5R(5), NMBR(3), NPY1R(3), NPY2R(3), NPY5R(3), NTSR1(5), NTSR2(3), OPRD1(1), OPRK1(6), OPRL1(6), OPRM1(3), OXTR(5), PPYR1(6), SSTR1(9), SSTR2(3), SSTR3(5), SSTR4(11), TACR1(3), TACR2(1), TACR3(11), TRHR(4), TSHR(8) 17171486 286 101 277 107 109 84 10 62 21 0 0.0725 1.000 1.000 295 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(2), ACTR3(2), AKT1(3), ANGPTL2(3), DAG1(8), DGKA(4), ETFA(1), GCA(2), ITGA9(7), ITPKA(1), ITPKB(7), ITPR1(21), ITPR2(20), ITPR3(30), MAP2K1(5), MAPK1(2), MAPK3(1), NR1I3(3), PAK1(5), PDE3A(11), PDE3B(13), PI3(1), PIK3C2G(7), PIK3CA(62), PIK3CD(10), PIK3R1(8), PLDN(1), PSME1(2), RIPK3(4), SGCB(3), VASP(2) 15991099 251 101 217 65 79 89 11 50 21 1 0.000332 1.000 1.000 296 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(22), ACSL1(2), ACSL3(6), ACSL4(2), ACSL5(5), ACSL6(5), ADIPOQ(3), ADIPOR1(4), ADIPOR2(4), AGRP(1), AKT1(3), AKT2(6), AKT3(6), CAMKK1(5), CAMKK2(1), CD36(2), CPT1A(7), CPT1B(3), CPT1C(6), CPT2(5), G6PC2(1), IKBKB(7), IRS1(15), IRS2(4), IRS4(16), JAK1(6), JAK2(10), JAK3(9), LEPR(13), MAPK10(5), MAPK8(5), MAPK9(4), NFKB1(7), NFKB2(2), NFKBIA(1), NFKBIB(5), NPY(1), PCK1(6), PCK2(7), POMC(6), PPARA(3), PPARGC1A(9), PRKAA1(4), PRKAA2(5), PRKAB1(2), PRKAB2(2), PRKAG1(3), PRKAG2(3), PRKAG3(2), PRKCQ(7), PTPN11(5), RELA(3), RXRA(3), RXRB(1), RXRG(5), SLC2A1(6), SLC2A4(4), SOCS3(3), STAT3(6), STK11(2), TNF(1), TNFRSF1A(3), TNFRSF1B(1), TRADD(2), TRAF2(2), TYK2(4) 27172795 319 100 317 121 116 74 9 81 39 0 0.394 1.000 1.000 297 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(1), BRAF(9), CREB1(3), DAXX(9), ELK1(3), FOS(1), GRB2(4), IKBKB(7), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K3(7), MAP2K4(7), MAP2K5(1), MAP2K6(1), MAP2K7(20), MAP3K1(9), MAP3K10(8), MAP3K11(7), MAP3K12(9), MAP3K13(7), MAP3K14(3), MAP3K2(3), MAP3K3(4), MAP3K4(15), MAP3K5(4), MAP3K6(5), MAP3K7(8), MAP3K9(3), MAP4K1(3), MAP4K2(4), MAP4K3(3), MAP4K4(8), MAP4K5(3), MAPK1(2), MAPK10(5), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK4(6), MAPK6(1), MAPK7(7), MAPK8(5), MAPK9(4), MAPKAPK2(1), MAPKAPK3(4), MAPKAPK5(1), MAX(3), MEF2B(4), MEF2C(3), MEF2D(6), MKNK1(3), MKNK2(1), MYC(3), NFKB1(7), NFKBIA(1), PAK1(5), PAK2(6), RAF1(7), RELA(3), RIPK1(1), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3), RPS6KA4(1), RPS6KA5(2), RPS6KB1(4), RPS6KB2(3), SHC1(3), SP1(6), STAT1(7), TGFB1(3), TGFB2(6), TGFB3(5), TGFBR1(5), TRADD(2), TRAF2(2) 31150346 348 100 340 125 122 91 16 63 56 0 0.284 1.000 1.000 298 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(3), AKT2(6), AKT3(6), BAD(3), BCR(9), BLNK(3), BTK(2), CD19(3), CSK(5), DAG1(8), EPHB2(8), GRB2(4), ITPKA(1), ITPKB(7), LYN(4), MAP2K1(5), MAP2K2(2), MAPK1(2), NFAT5(9), NFKB1(7), NFKB2(2), NFKBIA(1), NFKBIB(5), NFKBIL1(2), NFKBIL2(7), PI3(1), PIK3CA(62), PIK3CD(10), PIK3R1(8), PLCG2(11), PPP1R13B(6), RAF1(7), SERPINA4(2), SHC1(3), SOS1(6), SOS2(11), SYK(6), VAV1(6) 17293288 253 100 219 74 77 90 7 57 22 0 0.00918 1.000 1.000 299 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(3), AKT2(6), AKT3(6), BRAF(9), CAB39(1), EIF4B(4), EIF4EBP1(2), HIF1A(5), IGF1(4), MAPK1(2), MAPK3(1), PDPK1(2), PGF(1), PIK3CA(62), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PRKAA1(4), PRKAA2(5), RHEB(1), RICTOR(13), RPS6(1), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3), RPS6KA6(15), RPS6KB1(4), RPS6KB2(3), STK11(2), TSC1(3), TSC2(7), ULK1(11), ULK2(5), VEGFC(8) 17406613 266 99 229 66 98 85 11 50 22 0 0.000304 1.000 1.000 300 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(3), CDC40(5), CLK2(8), CLK3(8), CLK4(2), COL2A1(13), CPSF1(13), CPSF2(3), CPSF3(3), CPSF4(1), CSTF1(7), CSTF2(5), CSTF2T(4), CSTF3(5), DDIT3(3), DDX1(5), DDX20(4), DHX15(7), DHX16(4), DHX38(9), DHX8(10), DHX9(3), DICER1(8), DNAJC8(4), GIPC1(2), LOC440563(7), NCBP1(5), NONO(2), NUDT21(1), NXF1(5), PABPN1(2), PAPOLA(3), PHF5A(1), POLR2A(15), PPM1G(4), PRPF18(1), PRPF3(5), PRPF4(3), PRPF4B(10), PRPF8(13), PSKH1(4), PTBP1(5), PTBP2(1), RBM17(1), RBM5(4), RNGTT(3), RNMT(4), SF3A1(2), SF3A2(2), SF3A3(3), SF3B1(6), SF3B2(8), SF3B4(3), SF4(3), SFRS12(4), SFRS14(7), SFRS16(5), SFRS4(4), SFRS5(5), SFRS6(6), SFRS7(2), SFRS8(11), SFRS9(1), SNRPA(7), SNRPA1(2), SNRPB(1), SNRPB2(1), SNRPD1(2), SNRPD2(3), SNRPD3(2), SNRPE(1), SNRPN(5), SPOP(2), SRPK1(3), SRPK2(7), SRRM1(6), SUPT5H(7), U2AF1(3), U2AF2(3), XRN2(13) 34754765 378 98 376 119 140 111 19 72 36 0 0.113 1.000 1.000 301 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(2), AKT1(3), BDKRB2(3), CALM1(1), CALM2(3), CAV1(4), CHRM1(2), CHRNA1(4), FLT1(13), FLT4(17), KDR(8), NOS3(5), PDE2A(8), PDE3A(11), PDE3B(13), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKG1(8), PRKG2(10), RYR2(61), SLC7A1(4), SYT1(3), TNNI1(1) 13296629 206 96 206 79 64 59 7 63 13 0 0.375 1.000 1.000 302 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(2), AK3(5), CAD(12), CANT1(3), CTPS(2), CTPS2(3), DCTD(1), DHODH(2), DPYD(12), DPYS(7), DUT(1), ENTPD1(5), ENTPD3(4), ENTPD4(7), ENTPD6(2), ENTPD8(6), NME6(2), NME7(1), NT5C(1), NT5C1A(4), NT5C1B(5), NT5C2(7), NT5C3(1), NUDT2(3), PNPT1(4), POLA1(5), POLA2(3), POLD1(10), POLD2(1), POLD3(3), POLE(17), POLE2(3), POLE3(1), POLR1A(12), POLR1B(4), POLR1C(2), POLR1D(1), POLR2A(15), POLR2B(9), POLR2C(2), POLR2E(2), POLR2F(1), POLR2G(1), POLR2I(1), POLR2K(1), POLR3A(15), POLR3B(7), POLR3G(2), POLR3K(1), PRIM1(2), PRIM2(6), RFC5(1), RRM1(5), RRM2(3), RRM2B(4), TK1(1), TK2(2), TXNRD1(5), TXNRD2(2), TYMS(1), UCK1(5), UCK2(1), UMPS(3), UPB1(2), UPP2(4), UPRT(3) 26600100 271 95 267 97 98 72 13 60 28 0 0.219 1.000 1.000 303 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(2), ADAM17(5), ATP6AP1(5), ATP6V0A1(4), ATP6V0A2(5), ATP6V0A4(6), ATP6V0B(2), ATP6V0D1(6), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(6), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(5), CASP3(2), CCL5(1), CDC42(1), CSK(5), EGFR(11), F11R(2), GIT1(3), HBEGF(2), IGSF5(2), IKBKB(7), IL8(1), JAM2(2), JAM3(4), JUN(3), LYN(4), MAP2K4(7), MAP3K14(3), MAPK10(5), MAPK11(1), MAPK13(1), MAPK14(1), MAPK8(5), MAPK9(4), MET(7), NFKB1(7), NFKB2(2), NFKBIA(1), NOD1(8), PAK1(5), PLCG1(16), PLCG2(11), PTPN11(5), PTPRZ1(19), RELA(3), SRC(2), TCIRG1(6), TJP1(11) 23054693 253 94 248 97 74 73 8 67 31 0 0.523 1.000 1.000 304 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(3), INPP4A(3), INPP4B(5), INPP5A(5), INPPL1(14), ITPKA(1), ITPKB(7), MIOX(3), OCRL(8), PIK3C2A(8), PIK3C2B(15), PIK3C2G(7), PIK3CA(62), PIK3CB(7), PIK3CG(15), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), PLCD1(4), PLCG1(16), PLCG2(11) 14712530 228 93 190 59 69 90 10 45 14 0 0.00197 1.000 1.000 305 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(9), ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH5(3), ADH6(5), ADH7(1), ADHFE1(8), ALDH1A3(5), ALDH3A1(4), ALDH3B1(3), ALDH3B2(7), AOC2(4), AOC3(4), AOX1(7), CARM1(2), COMT(4), DBH(5), DCT(8), DDC(5), ESCO1(4), ESCO2(4), FAH(3), GOT1(2), GOT2(2), GSTZ1(3), HEMK1(1), HGD(3), HPD(1), LCMT1(1), LCMT2(7), MAOA(1), MAOB(3), METTL6(2), MIF(1), MYST3(20), MYST4(15), NAT6(2), PNMT(8), PNPLA3(1), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(4), PRMT8(3), SH3GLB1(1), TAT(4), TH(2), TPO(15), TYR(6), TYRP1(3), WBSCR22(4) 19503124 229 92 227 69 76 64 6 61 21 1 0.0226 1.000 1.000 306 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(3), AKT2(6), AKT3(6), ANKRD6(3), APC(34), AXIN1(8), AXIN2(4), CER1(2), CSNK1A1(3), CTNNB1(16), DACT1(8), DKK1(7), DKK2(4), DKK3(2), DKK4(1), DVL1(4), FSTL1(2), GSK3A(2), GSK3B(4), LRP1(25), MVP(5), NKD1(5), NKD2(1), PIN1(1), PSEN1(2), PTPRA(7), SENP2(2), SFRP1(4), TSHB(2), WIF1(2) 13210667 175 92 169 60 56 45 3 41 27 3 0.378 1.000 1.000 307 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ACCN1(3), ADCY4(5), ADCY6(10), ADCY8(21), CACNA1A(16), CACNA1B(22), GNAS(20), GNAT3(4), GNG13(2), GRM4(6), ITPR3(30), KCNB1(8), PDE1A(6), PLCB2(4), PRKACA(3), PRKACB(2), PRKACG(5), PRKX(4), SCNN1A(1), SCNN1B(7), SCNN1G(3), TAS1R1(6), TAS1R2(5), TAS1R3(7), TAS2R1(3), TAS2R13(3), TAS2R14(1), TAS2R16(5), TAS2R3(2), TAS2R38(5), TAS2R39(1), TAS2R4(4), TAS2R40(3), TAS2R41(1), TAS2R43(3), TAS2R5(3), TAS2R50(1), TAS2R60(3), TAS2R7(3), TAS2R8(1), TAS2R9(1), TRPM5(4) 18620215 247 91 244 97 93 72 10 57 15 0 0.390 1.000 1.000 308 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(3), AKT2(6), AKT3(6), BAD(3), BCL2(2), GRB2(4), GSK3A(2), GSK3B(4), IL4R(1), IRS1(15), IRS2(4), JAK1(6), JAK3(9), MAP4K1(3), MAPK1(2), MAPK3(1), PDK1(2), PIK3CA(62), PIK3CD(10), PIK3R1(8), PPP1R13B(6), RAF1(7), SHC1(3), SOCS1(1), SOS1(6), SOS2(11), STAT6(1) 11977363 188 90 153 42 60 71 5 34 18 0 0.000260 1.000 1.000 309 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(3), AKT2(6), AKT3(6), ASAH1(2), BRAF(9), DAG1(8), DRD2(7), EGFR(11), EPHB2(8), GRB2(4), ITPKA(1), ITPKB(7), ITPR1(21), ITPR2(20), ITPR3(30), KCNJ3(9), KCNJ5(3), MAPK1(2), PI3(1), PIK3CB(7), PITX2(4), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), RAF1(7), RGS20(4), SHC1(3), SOS1(6), SOS2(11), SRC(2), STAT3(6), TERF2IP(4) 19212115 246 90 241 96 97 64 7 61 16 1 0.498 1.000 1.000 310 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(2), CSK(5), CTLA4(3), DAG1(8), EPHB2(8), FBXW7(20), GRAP2(4), GRB2(4), ITK(5), ITPKA(1), ITPKB(7), LAT(2), LCK(3), LCP2(5), MAPK1(2), NCK1(6), NFAT5(9), NFKB1(7), NFKB2(2), NFKBIA(1), NFKBIB(5), NFKBIL1(2), NFKBIL2(7), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PAK7(7), PLCG1(16), PTPRC(15), RAF1(7), RASGRP1(5), RASGRP2(6), RASGRP3(4), RASGRP4(3), SOS1(6), SOS2(11), VAV1(6), ZAP70(10) 18311303 240 89 228 78 86 63 9 55 27 0 0.133 1.000 1.000 311 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(9), AGPAT1(3), AGPAT2(1), AGPAT3(2), AGPAT4(5), AGPAT6(3), CDIPT(1), CDS1(4), CDS2(2), CHAT(4), CHKA(1), CHKB(2), CHPT1(3), CRLS1(1), DGKA(4), DGKB(10), DGKD(2), DGKE(7), DGKG(1), DGKH(7), DGKI(9), DGKZ(4), ESCO1(4), ESCO2(4), ETNK1(1), ETNK2(1), GNPAT(1), GPAM(7), GPD1(6), GPD1L(3), GPD2(6), LCAT(4), MYST3(20), MYST4(15), NAT6(2), PCYT1A(6), PCYT1B(5), PEMT(1), PISD(5), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(1), PLA2G2D(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), PLD1(13), PLD2(13), PNPLA3(1), PPAP2A(1), PPAP2C(4), PTDSS1(3), PTDSS2(2), SH3GLB1(1) 21395653 243 88 242 87 82 76 9 55 20 1 0.163 1.000 1.000 312 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(7), AKT1(3), APC(34), ASAH1(2), CAMP(2), CAV3(2), DAG1(8), DLG4(3), EPHB2(8), GNAI1(1), GNAQ(3), ITPR1(21), ITPR2(20), ITPR3(30), KCNJ3(9), KCNJ5(3), MAPK1(2), PITX2(4), PTX3(2), RHO(6), RYR1(43) 15057186 213 88 208 79 87 45 7 45 26 3 0.259 1.000 1.000 313 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 APAF1(5), ARHGDIB(1), BAG4(1), BCL2(2), BID(2), BIRC2(3), BIRC3(3), CASP2(3), CASP3(2), CASP6(1), CASP7(2), CASP8(8), CASP9(2), CRADD(1), DAXX(9), DFFA(4), DFFB(3), GSN(9), LMNA(3), LMNB1(1), LMNB2(4), MAP2K7(20), MAP3K1(9), MAP3K14(3), MAP3K5(4), MAPK8(5), MDM2(3), NFKB1(7), NFKBIA(1), NUMA1(17), PAK2(6), PRKCD(7), PRKDC(32), PSEN1(2), PSEN2(2), PTK2(10), RASA1(11), RB1(6), RELA(3), RIPK1(1), SPTAN1(18), TNF(1), TNFRSF1A(3), TNFRSF1B(1), TRADD(2), TRAF1(3), TRAF2(2) 22692870 248 87 243 79 80 70 12 49 37 0 0.0971 1.000 1.000 314 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(2), ACTN1(6), ACTN2(22), ACTN3(2), BCAR1(4), BCR(9), CAPN1(2), CAPNS1(2), CAPNS2(2), CAV1(4), CRKL(1), CSK(5), FYN(8), GRB2(4), ITGA1(7), ITGB1(6), JUN(3), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK3(1), MAPK8(5), PPP1R12B(12), PTK2(10), PXN(3), RAF1(7), RAP1A(2), ROCK1(9), SHC1(3), SOS1(6), SRC(2), TLN1(14), VCL(1), ZYX(5) 15422014 178 86 173 68 63 45 9 47 13 1 0.451 1.000 1.000 315 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(5), APC(34), ATF2(1), AXIN1(8), BMP10(4), BMP2(2), BMP4(4), BMP5(9), BMP7(5), BMPR1A(3), BMPR2(11), CHRD(6), CTNNB1(16), DVL1(4), FZD1(7), GATA4(4), GSK3B(4), MAP3K7(8), MEF2C(3), MYL2(6), NKX2-5(3), NPPA(1), NPPB(2), RFC1(5), TGFB1(3), TGFB2(6), TGFB3(5), TGFBR1(5), TGFBR2(11), TGFBR3(4), WNT1(5) 11912653 194 85 188 66 51 47 9 42 40 5 0.402 1.000 1.000 316 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(7), AR(11), ESR1(7), ESR2(8), HNF4A(8), NR0B1(2), NR1D1(4), NR1D2(5), NR1H2(6), NR1H3(4), NR1I2(6), NR1I3(3), NR2C2(2), NR2E1(2), NR2F1(3), NR2F2(3), NR2F6(3), NR3C1(5), NR4A1(4), NR4A2(9), NR5A1(5), NR5A2(1), PGR(12), PPARA(3), PPARD(7), PPARG(1), RARA(2), RARB(6), ROR1(6), RORA(5), RORC(4), RXRA(3), RXRB(1), RXRG(5), THRA(4), THRB(7), VDR(3) 13747936 177 85 175 78 71 38 13 43 12 0 0.772 1.000 1.000 317 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 AK3(5), CAD(12), CANT1(3), CTPS(2), CTPS2(3), DCTD(1), DHODH(2), DPYD(12), DPYS(7), DUT(1), ENTPD1(5), NT5C(1), NUDT2(3), POLB(2), POLD1(10), POLD2(1), POLE(17), POLG(5), POLL(2), POLQ(22), POLR1B(4), POLR2A(15), POLR2B(9), POLR2C(2), POLR2E(2), POLR2F(1), POLR2G(1), POLR2I(1), POLR2K(1), POLRMT(10), RRM1(5), RRM2(3), TK1(1), TK2(2), TXNRD1(5), TYMS(1), UCK1(5), UCK2(1), UMPS(3), UNG(1), UPB1(2) 18781247 191 85 188 74 58 53 11 49 20 0 0.514 1.000 1.000 318 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(3), AKT2(6), AKT3(6), CISH(1), GRB2(4), IARS(9), IL13RA1(3), IL2RG(5), IL4(1), IL4R(1), INPP5D(1), JAK1(6), JAK2(10), JAK3(9), NR0B2(2), PI3(1), PIK3CA(62), PPP1R13B(6), RPS6KB1(4), SERPINA4(2), SHC1(3), SOS1(6), SOS2(11), SRC(2), STAT6(1), TYK2(4) 12113134 169 85 136 40 42 69 5 37 16 0 0.00341 1.000 1.000 319 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(3), BAD(3), BCL2(2), CBL(2), CRKL(1), E2F1(2), FOS(1), GRB2(4), IL2RA(2), IL2RB(2), IL2RG(5), IRS1(15), JAK1(6), JAK3(9), MAPK1(2), MAPK3(1), MYC(3), NMI(2), PIK3CA(62), PIK3R1(8), PTPN6(3), RAF1(7), RPS6KB1(4), SHC1(3), SOCS1(1), SOCS3(3), SOS1(6), STAT5A(4), STAT5B(6), SYK(6) 11846674 178 84 144 43 41 81 4 33 19 0 0.00139 1.000 1.000 320 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 BCL2(2), DAXX(9), EGF(8), EGFR(11), ETS1(5), ETS2(3), FOS(1), HOXA7(2), IKBKB(7), JUN(3), MAP2K1(5), MAP2K3(7), MAP2K4(7), MAP2K6(1), MAP2K7(20), MAP3K1(9), MAP3K14(3), MAP3K5(4), MAPK1(2), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(5), NFKB1(7), NFKBIA(1), PPP2CA(3), PRKCA(3), PRKCD(7), PRKCE(8), PRKCG(13), PRKCH(6), PRKCQ(7), RAF1(7), RELA(3), RIPK1(1), SP1(6), TNF(1), TNFRSF1A(3), TNFRSF1B(1), TRAF2(2) 16098619 196 84 190 68 72 51 5 38 30 0 0.142 1.000 1.000 321 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH5(3), ADH6(5), ADH7(1), ADHFE1(8), AGK(5), AGPAT1(3), AGPAT2(1), AGPAT3(2), AGPAT4(5), AGPAT6(3), AKR1A1(1), AKR1B1(6), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), CEL(7), DAK(5), DGAT1(1), DGAT2(1), DGKA(4), DGKB(10), DGKD(2), DGKE(7), DGKG(1), DGKH(7), DGKI(9), DGKZ(4), GK(3), GK2(3), GLB1(2), GPAM(7), LCT(15), LIPA(1), LIPC(2), LIPF(2), LIPG(2), LPL(4), MGLL(1), PNLIP(4), PNLIPRP1(3), PNLIPRP2(5), PNPLA3(1), PPAP2A(1), PPAP2C(4) 19253651 199 83 198 84 57 69 5 47 20 1 0.567 1.000 1.000 322 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(16), AKT1(3), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CREB1(3), GNAS(20), GRB2(4), MAPK1(2), MAPK14(1), MAPK3(1), PIK3CA(62), PIK3R1(8), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKCA(3), RPS6KA1(6), RPS6KA5(2), SOS1(6) 9552299 171 82 139 46 52 75 3 27 14 0 0.0113 1.000 1.000 323 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(6), ALPL(4), ALPP(7), ALPPL2(6), ASCC3(24), ATP13A2(10), DDX18(8), DDX19A(4), DDX23(7), DDX4(4), DDX41(7), DDX47(2), DDX50(6), DDX51(2), DDX52(1), DDX54(13), DDX55(3), DDX56(4), DHX58(7), ENTPD7(9), EP400(25), ERCC2(5), ERCC3(7), FPGS(1), GGH(3), IFIH1(5), MOV10L1(3), NUDT5(1), QDPR(1), RAD54B(3), RAD54L(4), RUVBL2(2), SETX(12), SKIV2L2(7), SMARCA2(16), SMARCA5(3), SPR(2) 20604849 234 82 233 90 92 62 8 51 21 0 0.482 1.000 1.000 324 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(34), AXIN1(8), CREBBP(26), CTNNB1(16), DVL1(4), EP300(19), FZD1(7), GSK3B(4), HDAC1(3), LDB1(4), LEF1(5), PITX2(4), TRRAP(37), WNT1(5) 10862484 176 82 168 52 64 39 5 32 33 3 0.0571 1.000 1.000 325 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(3), CDK5(2), CDK5R1(1), CFL1(1), CHN1(3), LIMK1(3), MAP3K1(9), MYL2(6), MYLK(15), NCF2(2), PAK1(5), PDGFRA(11), PIK3CA(62), PIK3R1(8), PLD1(13), PPP1R12B(12), RALBP1(5), RPS6KB1(4), TRIO(26), VAV1(6), WASF1(3) 11473973 200 82 167 52 53 84 5 37 21 0 0.00394 1.000 1.000 326 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(13), AMY2A(3), AMY2B(13), ENPP1(5), ENPP3(4), GAA(2), GANAB(4), GBA3(1), GBE1(3), GCK(4), GPI(5), GUSB(8), GYS1(3), GYS2(4), HK1(11), HK2(8), HK3(5), MGAM(9), PGM1(2), PGM3(10), PYGB(8), PYGL(6), PYGM(9), RNPC3(1), SI(19), UCHL1(1), UCHL3(3), UGDH(5), UGT1A1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A5(8), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2B15(2), UGT2B4(3), UXS1(3) 18675629 196 81 196 68 55 62 4 51 24 0 0.227 1.000 1.000 327 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(34), AXIN1(8), BTRC(4), CCND1(1), CREBBP(26), CSNK1A1(3), CSNK1D(2), CSNK2A1(7), CTBP1(3), CTNNB1(16), DVL1(4), FZD1(7), GSK3B(4), HDAC1(3), MAP3K7(8), MYC(3), NLK(6), PPARD(7), PPP2CA(3), TLE1(5), WIF1(2), WNT1(5) 9597024 161 81 153 44 50 38 8 27 35 3 0.0360 1.000 1.000 328 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(16), AKT1(3), ASAH1(2), GNAI1(1), GNGT1(3), ITGAV(5), ITGB3(3), MAPK1(2), MAPK3(1), PDGFA(2), PDGFRA(11), PIK3CA(62), PIK3R1(8), PLCB1(13), PRKCA(3), PTK2(10), SMPD1(5), SMPD2(1), SPHK1(4), SRC(2) 9015899 157 80 125 44 41 73 7 21 15 0 0.00715 1.000 1.000 329 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(5), AASS(6), ACAT1(3), ACAT2(3), AKR1B10(2), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), BBOX1(3), DLST(4), DOT1L(8), EHHADH(6), EHMT1(10), EHMT2(6), GCDH(5), HADH(3), HADHA(4), HSD17B4(4), HSD3B7(4), NSD1(16), OGDH(7), OGDHL(10), PIPOX(3), PLOD1(7), PLOD2(6), PLOD3(8), RDH11(1), RDH12(1), RDH13(3), SETD1A(9), SETD7(1), SETDB1(13), SHMT1(1), SHMT2(5), SPCS1(1), SPCS3(2), SUV39H1(5), SUV39H2(2), TMLHE(5) 19021800 210 80 207 68 71 62 7 43 27 0 0.0829 1.000 1.000 330 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACADL(2), ACADM(4), ACOX1(4), ACOX2(6), ACOX3(8), ACSL1(2), ACSL3(6), ACSL4(2), ACSL5(5), ACSL6(5), ADIPOQ(3), ANGPTL4(2), APOA1(5), APOA5(5), AQP7(2), CD36(2), CPT1A(7), CPT1B(3), CPT1C(6), CPT2(5), CYP27A1(4), CYP4A11(2), CYP4A22(2), CYP7A1(4), CYP8B1(5), EHHADH(6), FABP2(1), FABP3(1), FABP5(1), FABP6(3), FABP7(1), FADS2(4), GK(3), GK2(3), HMGCS2(3), ILK(3), LPL(4), ME1(1), MMP1(3), NR1H3(4), OLR1(2), PCK1(6), PCK2(7), PDPK1(2), PLTP(2), PPARA(3), PPARD(7), PPARG(1), RXRA(3), RXRB(1), RXRG(5), SCD(1), SCP2(4), SLC27A1(3), SLC27A2(4), SLC27A4(6), SLC27A5(4), SLC27A6(7), SORBS1(7), UBC(5), UCP1(1) 21504904 223 80 220 81 85 44 16 59 19 0 0.322 1.000 1.000 331 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(8), CALR(3), CANX(1), CD4(5), CD74(1), CD8A(4), CD8B(2), CIITA(13), CREB1(3), CTSL1(2), CTSS(1), HLA-A(6), HLA-B(12), HLA-C(3), HLA-DMA(1), HLA-DMB(3), HLA-DOA(1), HLA-DPB1(2), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(6), HLA-E(3), HLA-F(7), HLA-G(3), HSP90AA1(7), HSP90AB1(4), IFI30(2), IFNA1(1), IFNA10(5), IFNA13(1), IFNA16(2), IFNA17(4), IFNA2(1), IFNA21(1), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(4), IFNA8(1), KIR2DL1(5), KIR2DL3(2), KIR2DL4(3), KIR2DS4(2), KIR3DL1(5), KIR3DL2(1), KLRC1(3), KLRC2(2), KLRC3(4), KLRD1(4), LGMN(4), LTA(3), NFYC(1), PDIA3(2), PSME1(2), PSME2(1), RFX5(6), RFXANK(3), TAP1(2), TAP2(10), TAPBP(3) 15218509 199 80 194 56 35 65 18 54 25 2 0.0252 1.000 1.000 332 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(16), ARHGEF1(9), F2(5), F2R(2), F2RL3(1), GNA12(1), GNA13(3), GNAI1(1), GNAQ(3), GNGT1(3), MAP3K7(8), PIK3CA(62), PIK3R1(8), PLCB1(13), PPP1R12B(12), PRKCA(3), PTK2B(10), ROCK1(9) 8485832 169 80 137 45 44 72 5 29 18 1 0.00955 1.000 1.000 333 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG2(7), ACTR2(2), ACTR3(2), AKT1(3), ANGPTL2(3), CDC42(1), CFL1(1), FLNA(16), FLNC(22), FSCN1(5), FSCN3(11), GDI1(2), GDI2(3), LIMK1(3), MYH2(23), MYLK(15), MYLK2(2), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PAK7(7), PFN2(2), RHO(6), ROCK1(9), ROCK2(7), VASP(2), WASF1(3), WASL(1) 15700591 184 80 183 66 75 49 6 37 16 1 0.173 1.000 1.000 334 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(12), GABBR1(8), GPRC5B(8), GPRC5C(3), GPRC5D(2), GRM1(26), GRM2(19), GRM3(12), GRM4(6), GRM5(23), GRM7(15), GRM8(15) 6883262 149 79 141 55 67 26 7 39 10 0 0.225 1.000 1.000 335 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(18), COL4A2(10), COL4A3(8), COL4A4(10), COL4A5(9), COL4A6(6), F10(6), F11(3), F12(2), F2(5), F2R(2), F5(13), F8(15), F9(6), FGA(7), FGB(2), FGG(2), KLKB1(7), PROC(2), PROS1(8), SERPINC1(4), SERPING1(5) 14598158 150 79 150 56 40 45 7 48 10 0 0.298 1.000 1.000 336 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(30), BMPR1B(4), CCND2(3), DMC1(4), EGR1(4), ESR2(8), FSHR(18), GJA4(2), INHA(3), LHCGR(10), MLH1(3), MSH5(3), NCOR1(24), NR5A1(5), NRIP1(11), PGR(12), PRLR(2), PTGER2(4), SMPD1(5), VDR(3), ZP2(7) 11484100 165 79 162 49 45 53 7 41 16 3 0.0519 1.000 1.000 337 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(4), ABO(1), B3GALNT1(2), B3GALT1(3), B3GALT2(6), B3GALT4(4), B3GALT5(1), B3GNT1(3), B3GNT2(2), B3GNT3(5), B3GNT4(4), B3GNT5(3), B4GALNT1(3), B4GALT1(2), B4GALT2(5), B4GALT3(2), B4GALT4(4), B4GALT6(2), FUT1(2), FUT3(1), FUT4(1), FUT5(2), FUT6(2), FUT7(2), FUT9(5), GBGT1(1), GCNT2(1), PIGA(2), PIGB(5), PIGC(3), PIGG(8), PIGK(3), PIGL(2), PIGM(5), PIGN(5), PIGO(4), PIGP(1), PIGQ(2), PIGS(3), PIGT(2), PIGU(1), PIGV(4), PIGX(2), PIGZ(2), ST3GAL1(4), ST3GAL2(4), ST3GAL3(1), ST3GAL4(4), ST3GAL5(2), ST3GAL6(3), ST6GALNAC3(5), ST6GALNAC5(1), ST6GALNAC6(2), ST8SIA1(4), ST8SIA5(4), UGCG(3) 15889413 164 78 161 76 67 40 4 39 13 1 0.871 1.000 1.000 338 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(5), APH1A(1), CREBBP(26), CTBP1(3), CTBP2(5), DLL1(10), DLL3(5), DLL4(3), DTX1(11), DTX2(4), DTX3(1), DTX3L(1), DTX4(6), DVL1(4), DVL2(3), DVL3(8), EP300(19), HDAC1(3), HDAC2(2), JAG1(10), JAG2(4), MAML1(5), MAML2(6), MAML3(8), NCOR2(21), NCSTN(4), NOTCH1(19), NOTCH2(19), NOTCH3(16), NOTCH4(11), NUMB(2), NUMBL(3), PSEN1(2), PSEN2(2), PSENEN(2), PTCRA(1), RBPJ(5), RBPJL(2), RFNG(2), SNW1(3) 22550659 267 78 263 123 104 65 14 52 32 0 0.802 1.000 1.000 339 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(5), BAD(3), BAX(1), BCL2(2), BCL2L2(1), BOK(1), CASP1(2), CASP10(5), CASP2(3), CASP3(2), CASP4(4), CASP6(1), CASP7(2), CASP8(8), CASP9(2), CD40(1), CD40LG(4), CRADD(1), DAXX(9), DFFA(4), DFFB(3), FAS(3), FASLG(2), IKBKE(8), LTA(3), MCL1(1), NFKB1(7), NFKBIA(1), NGFR(4), NR3C1(5), NTRK1(6), PTPN13(16), RIPK1(1), SFRS2IP(12), TFG(1), TNF(1), TNFRSF1A(3), TNFRSF1B(1), TRADD(2), TRAF1(3), TRAF2(2), TRAF3(3), TRAF6(5) 14249159 154 76 151 57 39 37 13 44 21 0 0.508 1.000 1.000 340 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH6(5), ADH7(1), ADHFE1(8), AGPAT1(3), AGPAT2(1), AGPAT3(2), AGPAT4(5), AKR1A1(1), AKR1B1(6), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), CEL(7), DGAT1(1), DGKA(4), DGKB(10), DGKD(2), DGKE(7), DGKG(1), DGKH(7), DGKZ(4), GK(3), GLB1(2), LCT(15), LIPC(2), LIPF(2), LIPG(2), LPL(4), PNLIP(4), PNLIPRP1(3), PNLIPRP2(5), PPAP2A(1), PPAP2C(4) 15816961 168 76 167 80 49 55 4 42 17 1 0.860 1.000 1.000 341 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(9), ACSS2(6), ACYP1(1), ACYP2(3), ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH5(3), ADH6(5), ADH7(1), ADHFE1(8), AKR1A1(1), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH3B1(3), ALDH3B2(7), ALDH9A1(3), ALDOB(3), ALDOC(3), BPGM(3), DLAT(3), DLD(3), ENO1(2), ENO2(3), ENO3(4), FBP1(2), FBP2(4), G6PC2(1), GALM(3), GAPDH(1), GAPDHS(3), GCK(4), GPI(5), HK1(11), HK2(8), HK3(5), LDHA(3), LDHAL6B(4), LDHB(4), LDHC(1), PDHA1(1), PDHA2(4), PDHB(3), PFKL(4), PFKM(3), PFKP(8), PGAM2(4), PGAM4(2), PGK1(4), PGK2(2), PGM1(2), PGM3(10), PKLR(5), PKM2(5), TPI1(1) 19096741 226 75 225 88 65 72 9 59 21 0 0.406 1.000 1.000 342 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(14), CARM1(2), CCND1(1), CREBBP(26), EP300(19), ERCC3(7), ESR1(7), GRIP1(12), GTF2A1(2), GTF2E1(4), GTF2F1(5), HDAC1(3), HDAC2(2), HDAC3(4), HDAC4(13), HDAC5(6), HDAC6(6), MEF2C(3), NCOR2(21), NR0B1(2), NRIP1(11), PELP1(5), POLR2A(15), SRA1(2), TBP(2) 15055680 194 74 190 59 70 59 7 36 22 0 0.0201 1.000 1.000 343 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(9), AGPAT1(3), AGPAT2(1), AGPAT3(2), AGPAT4(5), AGPS(1), CDIPT(1), CDS1(4), CDS2(2), CHAT(4), CHKA(1), CHKB(2), CLC(1), CPT1B(3), DGKA(4), DGKB(10), DGKD(2), DGKE(7), DGKG(1), DGKH(7), DGKZ(4), ETNK1(1), GNPAT(1), GPD1(6), GPD2(6), LCAT(4), PAFAH1B1(5), PAFAH2(1), PCYT1A(6), PCYT1B(5), PEMT(1), PISD(5), PLA2G2A(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), PLCB2(4), PLCG1(16), PLCG2(11), PPAP2A(1), PPAP2C(4) 16351742 174 74 171 71 60 54 6 41 12 1 0.548 1.000 1.000 344 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(11), ATP4A(11), ATP4B(1), ATP5A1(2), ATP5B(3), ATP5C1(3), ATP5F1(1), ATP5G2(1), ATP5J(1), ATP5J2(1), ATP5L(2), ATP6AP1(5), ATP6V0A1(4), ATP6V0A2(5), ATP6V0A4(6), ATP6V0B(2), ATP6V0D1(6), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(6), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(5), COX10(1), COX15(5), COX4I1(3), COX4I2(1), COX6B1(2), COX7A2(1), COX7C(1), COX8C(1), LHPP(3), NDUFA1(1), NDUFA10(1), NDUFA13(3), NDUFA3(1), NDUFA6(1), NDUFA8(5), NDUFA9(2), NDUFAB1(2), NDUFB2(1), NDUFB3(2), NDUFB4(1), NDUFB5(1), NDUFB6(1), NDUFB7(1), NDUFB8(1), NDUFB9(1), NDUFC2(2), NDUFS1(6), NDUFS2(2), NDUFS3(1), NDUFS4(1), NDUFS5(2), NDUFS6(3), NDUFS7(3), NDUFS8(2), NDUFV1(2), PPA1(2), PPA2(3), SDHA(6), SDHB(4), SDHC(1), TCIRG1(6), UQCRB(1), UQCRC1(2), UQCRC2(3), UQCRFS1(1), UQCRQ(1) 18281319 200 74 197 87 68 63 8 47 14 0 0.806 1.000 1.000 345 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(12), ADRA1B(4), ADRA1D(2), ADRA2A(5), ADRA2C(4), ADRB1(7), ADRB2(7), CHRM1(2), CHRM2(13), CHRM3(9), CHRM4(2), CHRM5(1), DRD1(3), DRD2(7), DRD3(7), DRD4(2), DRD5(10), HRH1(4), HRH2(8), HTR1A(10), HTR1B(8), HTR1D(3), HTR1E(5), HTR1F(5), HTR2A(5), HTR2B(4), HTR2C(5), HTR4(4), HTR5A(7), HTR6(2), HTR7(8) 8415536 175 74 172 67 65 42 11 45 12 0 0.209 1.000 1.000 346 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(16), CALM1(1), CALM2(3), CREB1(3), ELK1(3), FOS(1), GNAI1(1), GNAQ(3), GNAS(20), GNGT1(3), JUN(3), MAP2K1(5), MAPK3(1), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(12), PLCG1(16), PPP3CA(5), PPP3CB(6), PPP3CC(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKCA(3), RAF1(7), RPS6KA3(3), SYT1(3) 11459617 172 73 167 56 71 49 2 32 18 0 0.0707 1.000 1.000 347 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(3), AKT2(6), AKT3(6), ARHGEF11(12), BCL2(2), CDC42(1), DLG4(3), GNA13(3), LPA(14), MAP2K4(7), MAP3K1(9), MAP3K5(4), MAPK8(5), NFKB1(7), NFKB2(2), NFKBIA(1), NFKBIB(5), NFKBIL1(2), NFKBIL2(7), PDK1(2), PHKA2(9), PI3(1), PIK3CB(7), PLD1(13), PLD2(13), PLD3(4), PTK2(10), RDX(4), ROCK1(9), ROCK2(7), SERPINA4(2), SRF(1), TBXA2R(8) 16107373 189 73 184 58 74 55 9 25 25 1 0.0593 1.000 1.000 348 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(4), EEF1B2(3), EEF1D(2), EEF1G(4), EEF2(4), EEF2K(7), EIF1AX(2), EIF1AY(1), EIF2AK1(3), EIF2AK2(5), EIF2AK3(10), EIF2B1(3), EIF2B2(3), EIF2B3(5), EIF2B4(6), EIF2B5(6), EIF2S1(2), EIF2S2(3), EIF4A1(3), EIF4A2(4), EIF4E(2), EIF4EBP1(2), EIF4EBP2(1), EIF4G1(19), EIF4G3(7), EIF5(5), EIF5A(3), EIF5B(9), ETF1(4), GSPT2(1), KIAA0664(8), PABPC1(2), PABPC3(8), PAIP1(2), SLC35A4(4) 14309794 157 73 155 50 51 50 7 35 14 0 0.119 1.000 1.000 349 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(9), ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH6(5), ADH7(1), ADHFE1(8), ALDH1A3(5), ALDH3A1(4), ALDH3B1(3), ALDH3B2(7), AOC2(4), AOC3(4), AOX1(7), COMT(4), DBH(5), DCT(8), DDC(5), FAH(3), GOT1(2), GOT2(2), GSTZ1(3), HGD(3), HPD(1), MAOA(1), MAOB(3), PNMT(8), TAT(4), TH(2), TPO(15), TYR(6) 10394738 142 73 140 44 49 40 3 40 9 1 0.0607 1.000 1.000 350 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(3), BTK(2), CALM1(1), CALM2(3), CD79A(6), CD79B(1), ELK1(3), FOS(1), GRB2(4), JUN(3), LYN(4), MAP2K1(5), MAP3K1(9), MAPK14(1), MAPK3(1), MAPK8(5), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(12), PLCG1(16), PPP3CA(5), PPP3CB(6), PPP3CC(3), PRKCA(3), RAF1(7), SHC1(3), SOS1(6), SYK(6), SYT1(3), VAV1(6) 12552425 157 72 151 41 64 43 3 31 16 0 0.00685 1.000 1.000 351 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(4), CALCR(6), CALCRL(5), CD97(1), CRHR1(10), CRHR2(3), ELTD1(14), EMR1(14), EMR2(9), GHRHR(4), GIPR(3), GLP1R(1), GLP2R(8), GPR64(10), LPHN1(13), LPHN2(17), LPHN3(14), SCTR(2), VIPR1(2), VIPR2(3) 8739085 143 72 140 42 36 40 6 46 15 0 0.0470 1.000 1.000 352 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(4), ADC(1), ALDH4A1(4), ALDH5A1(5), CAD(12), CPS1(18), EARS2(3), EPRS(7), GAD1(6), GAD2(7), GCLC(1), GCLM(2), GFPT1(3), GFPT2(4), GLS(8), GLS2(6), GLUD1(3), GLUD2(10), GLUL(5), GMPS(4), GNPNAT1(2), GOT1(2), GOT2(2), GPT(1), GPT2(2), GSR(4), GSS(3), NADSYN1(4), PPAT(3), QARS(3) 12964519 139 72 138 59 43 44 5 38 9 0 0.763 1.000 1.000 353 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(9), AGXT(1), AGXT2(7), AKR1B10(2), ALAS1(2), ALAS2(9), AMT(3), AOC2(4), AOC3(4), BHMT(4), CBS(5), CHDH(4), CHKA(1), CHKB(2), CTH(2), DAO(8), DLD(3), DMGDH(7), GARS(1), GATM(3), GCAT(2), GLDC(7), GNMT(2), HSD3B7(4), MAOA(1), MAOB(3), PEMT(1), PHGDH(1), PIPOX(3), PISD(5), PSAT1(3), PSPH(2), RDH11(1), RDH12(1), RDH13(3), SARDH(10), SARS(4), SARS2(6), SDS(2), SHMT1(1), SHMT2(5), TARS(6), TARS2(5) 13993365 159 72 158 58 56 39 12 35 17 0 0.330 1.000 1.000 354 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH5(3), ADH6(5), ADH7(1), ADHFE1(8), AKR1C1(1), AKR1C3(2), AKR1C4(5), ALDH1A3(5), ALDH3A1(4), ALDH3B1(3), ALDH3B2(7), CYP1A1(4), CYP1A2(4), CYP1B1(2), CYP2B6(6), CYP2C18(3), CYP2C19(7), CYP2C8(1), CYP2E1(4), CYP2F1(5), CYP2S1(7), CYP3A4(2), CYP3A43(4), CYP3A7(4), DHDH(5), EPHX1(4), GSTA1(2), GSTA2(1), GSTA4(2), GSTA5(2), GSTK1(1), GSTM2(1), GSTM3(2), GSTM4(2), GSTM5(1), GSTO2(3), GSTZ1(3), MGST1(2), MGST3(2), UGT1A1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A5(8), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2A1(3), UGT2A3(3), UGT2B10(8), UGT2B11(2), UGT2B15(2), UGT2B28(5), UGT2B4(3), UGT2B7(3) 18767768 188 72 187 56 51 61 2 54 20 0 0.0507 1.000 1.000 355 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(28), B3GALT4(4), CDR1(4), DGKI(9), IL6ST(4), PIGK(3), RPL10(6), RPL12(1), RPL13A(2), RPL14(1), RPL18(1), RPL19(2), RPL24(1), RPL26(1), RPL28(1), RPL3(2), RPL31(1), RPL34(2), RPL36(1), RPL38(1), RPL3L(2), RPL5(1), RPL6(1), RPL7(1), RPL7A(2), RPL8(2), RPL9(3), RPLP0(3), RPLP1(1), RPLP2(1), RPS10(1), RPS11(1), RPS13(2), RPS14(2), RPS23(1), RPS24(1), RPS27(1), RPS27A(1), RPS3(1), RPS3A(2), RPS4Y1(1), RPS5(3), RPS6(1), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3), RPS6KA6(15), RPS6KB1(4), RPS6KB2(3), RPS9(1), RPSA(6), SLC36A2(7), TBC1D10C(2), TSPAN9(1), UBA52(1), UBC(5) 17189314 172 72 170 70 45 56 8 43 19 1 0.825 1.000 1.000 356 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(7), AKT1(3), AKT2(6), AKT3(6), DAG1(8), GNAQ(3), ITPKA(1), ITPKB(7), ITPR1(21), ITPR2(20), ITPR3(30), NFKB1(7), NFKB2(2), NFKBIA(1), NFKBIB(5), NFKBIL1(2), NFKBIL2(7), PDK1(2), PHKA2(9), PIK3CB(7), PITX2(4), PLD1(13), PLD2(13), PLD3(4), VN1R1(2) 14718492 190 72 189 61 79 48 10 39 13 1 0.0655 1.000 1.000 357 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), BAG4(1), CASP2(3), CASP3(2), CASP8(8), CRADD(1), DFFA(4), DFFB(3), JUN(3), LMNA(3), LMNB1(1), LMNB2(4), MADD(15), MAP2K4(7), MAP3K1(9), MAP3K7(8), MAPK8(5), PAK1(5), PAK2(6), PRKDC(32), RB1(6), RIPK1(1), SPTAN1(18), TNF(1), TNFRSF1A(3), TRADD(2), TRAF2(2) 12732697 154 72 151 51 46 46 8 30 24 0 0.227 1.000 1.000 358 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(3), AGTR2(2), CALM1(1), CALM2(3), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CDK5(2), F2(5), FYN(8), GNA11(5), GNAI1(1), GNGT1(3), GRB2(4), JAK2(10), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK14(1), MAPK3(1), MAPK8(5), MAPT(4), MYLK(15), PLCG1(16), PRKCA(3), PTK2B(10), RAF1(7), SHC1(3), SOS1(6), STAT1(7), STAT3(6), STAT5A(4), SYT1(3) 13661694 159 71 155 53 57 46 6 38 12 0 0.184 1.000 1.000 359 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM1(1), CALM2(3), CAMK1(2), CAMK1G(3), ELK1(3), FPR1(4), GNA15(3), GNGT1(3), MAP2K1(5), MAP2K2(2), MAP2K3(7), MAP2K6(1), MAP3K1(9), MAPK1(2), MAPK14(1), MAPK3(1), NCF1(3), NCF2(2), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(12), NFKB1(7), NFKBIA(1), PAK1(5), PIK3C2G(7), PLCB1(13), PPP3CA(5), PPP3CB(6), PPP3CC(3), RAF1(7), RELA(3), SYT1(3) 12542950 156 71 151 56 53 43 4 35 21 0 0.271 1.000 1.000 360 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(5), AANAT(1), ABP1(9), ACAT1(3), ACAT2(3), ACMSD(4), AFMID(1), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), AOC2(4), AOC3(4), AOX1(7), ASMT(3), CARM1(2), CAT(4), CYP1A1(4), CYP1A2(4), CYP1B1(2), DDC(5), EHHADH(6), GCDH(5), HADH(3), HADHA(4), HEMK1(1), HSD17B4(4), INMT(2), KMO(1), KYNU(8), LCMT1(1), LCMT2(7), LNX1(4), MAOA(1), MAOB(3), METTL6(2), NFX1(2), OGDH(7), OGDHL(10), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(4), PRMT8(3), TDO2(5), TPH1(3), TPH2(5), WARS(3), WARS2(7), WBSCR22(4) 19876306 207 71 202 70 59 67 10 43 27 1 0.121 1.000 1.000 361 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(6), F11(3), F12(2), F13B(13), F2(5), F5(13), F7(9), F8(15), F9(6), FGA(7), FGB(2), FGG(2), LPA(14), PLAT(4), PLAU(2), PLG(11), SERPINB2(6), SERPINE1(3), SERPINF2(5), VWF(19) 11587373 147 70 145 41 44 40 8 44 11 0 0.0354 1.000 1.000 362 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ACYP2(3), ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH6(5), ADH7(1), ADHFE1(8), AKR1A1(1), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH3B1(3), ALDH3B2(7), ALDH9A1(3), ALDOB(3), ALDOC(3), BPGM(3), DLAT(3), DLD(3), ENO1(2), ENO2(3), ENO3(4), FBP1(2), FBP2(4), GAPDH(1), GCK(4), GPI(5), HK1(11), HK2(8), HK3(5), LDHA(3), LDHB(4), LDHC(1), PDHA1(1), PDHA2(4), PDHB(3), PFKM(3), PFKP(8), PGK1(4), PGM1(2), PGM3(10), PKLR(5), PKM2(5), TPI1(1) 16043828 193 70 192 78 54 58 7 55 19 0 0.608 1.000 1.000 363 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ACYP2(3), ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH6(5), ADH7(1), ADHFE1(8), AKR1A1(1), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH3B1(3), ALDH3B2(7), ALDH9A1(3), ALDOB(3), ALDOC(3), BPGM(3), DLAT(3), DLD(3), ENO1(2), ENO2(3), ENO3(4), FBP1(2), FBP2(4), GAPDH(1), GCK(4), GPI(5), HK1(11), HK2(8), HK3(5), LDHA(3), LDHB(4), LDHC(1), PDHA1(1), PDHA2(4), PDHB(3), PFKM(3), PFKP(8), PGK1(4), PGM1(2), PGM3(10), PKLR(5), PKM2(5), TPI1(1) 16043828 193 70 192 78 54 58 7 55 19 0 0.608 1.000 1.000 364 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ABP1(9), ACAT1(3), ACAT2(3), ACMSD(4), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), AOC2(4), AOC3(4), AOX1(7), ASMT(3), CAT(4), CYP19A1(9), CYP1A1(4), CYP1A2(4), CYP2A13(7), CYP2A6(5), CYP2A7(5), CYP2B6(6), CYP2C18(3), CYP2C19(7), CYP2C8(1), CYP2D6(4), CYP2E1(4), CYP2F1(5), CYP2J2(4), CYP3A4(2), CYP3A7(4), CYP4B1(7), CYP4F8(2), CYP51A1(6), DDC(5), EHHADH(6), GCDH(5), HADHA(4), KMO(1), KYNU(8), MAOA(1), MAOB(3), SDS(2), TDO2(5), TPH1(3), WARS(3), WARS2(7) 18080179 220 70 215 66 65 68 6 55 25 1 0.0475 1.000 1.000 365 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(9), AGMAT(1), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH4A1(4), ALDH9A1(3), AMD1(3), AOC2(4), AOC3(4), ARG1(2), ASL(5), CKB(1), CKMT1A(3), CKMT1B(1), CKMT2(6), CPS1(18), DAO(8), GATM(3), GLUD1(3), GOT1(2), GOT2(2), MAOA(1), MAOB(3), NOS1(22), NOS3(5), ODC1(3), OTC(2), P4HA1(3), P4HA2(8), P4HA3(4), P4HB(2), PYCR1(3), RARS(4), SMS(3) 14491519 178 69 177 54 64 54 8 38 14 0 0.0376 1.000 1.000 366 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(5), CDC7(3), CDK2(3), CDT1(3), DIAPH2(6), GMNN(1), MCM10(7), MCM2(11), MCM3(3), MCM4(8), MCM5(5), MCM6(2), MCM7(5), NACA(2), ORC1L(8), ORC2L(2), ORC3L(5), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), POLA2(3), POLD1(10), POLD2(1), POLD3(3), POLE(17), POLE2(3), PRIM1(2), RFC1(5), RFC2(1), RFC3(2), RFC4(1), RFC5(1), RPA1(1), RPA2(1), RPA3(2), RPA4(5), RPS27A(1), UBA52(1), UBC(5) 16668244 153 69 152 53 58 38 9 27 21 0 0.239 1.000 1.000 367 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(5), APC(34), AXIN1(8), BTRC(4), CTNNB1(16), DLL1(10), DVL1(4), FZD1(7), GSK3B(4), NOTCH1(19), PSEN1(2), WNT1(5) 6976055 118 69 113 42 39 21 6 23 26 3 0.387 1.000 1.000 368 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(2), ACTN1(6), ACTN2(22), ACTN3(2), CAPN1(2), CAPNS1(2), CAPNS2(2), ITGA1(7), ITGB1(6), ITGB3(3), PTK2(10), PXN(3), SPTAN1(18), SRC(2), TLN1(14) 9349683 101 69 98 51 41 23 8 22 7 0 0.922 1.000 1.000 369 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CASP10(5), CASP3(2), CASP6(1), CASP7(2), CASP8(8), DAXX(9), DFFA(4), DFFB(3), FAF1(8), JUN(3), LMNA(3), LMNB1(1), LMNB2(4), MAP2K4(7), MAP3K1(9), MAP3K7(8), MAPK8(5), PAK1(5), PAK2(6), PRKDC(32), PTPN13(16), RB1(6), RIPK2(1), SPTAN1(18) 13388742 167 68 163 51 40 55 9 35 28 0 0.133 1.000 1.000 370 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(9), AGXT(1), AGXT2(7), ALAS1(2), ALAS2(9), AMT(3), AOC2(4), AOC3(4), BHMT(4), CBS(5), CHDH(4), CHKA(1), CHKB(2), CPT1B(3), CTH(2), DAO(8), DLD(3), DMGDH(7), GARS(1), GATM(3), GCAT(2), GLDC(7), MAOA(1), MAOB(3), PEMT(1), PISD(5), PLCB2(4), PLCG1(16), PLCG2(11), PSPH(2), SARDH(10), SARS(4), SHMT1(1), SHMT2(5), TARS(6) 13766858 160 68 157 58 50 40 10 41 19 0 0.414 1.000 1.000 371 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(9), ALDH1A3(5), ALDH3A1(4), ALDH3B1(3), ALDH3B2(7), AOC2(4), AOC3(4), DDC(5), EPX(6), ESCO1(4), ESCO2(4), GOT1(2), GOT2(2), HPD(1), LPO(7), MAOA(1), MAOB(3), MIF(1), MPO(6), MYST3(20), MYST4(15), NAT6(2), PNPLA3(1), PRDX6(1), SH3GLB1(1), TAT(4), TPO(15) 11214464 137 68 137 36 45 37 4 40 11 0 0.0249 1.000 1.000 372 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(9), AADAC(3), ABAT(4), ACADS(3), ACAT1(3), ACAT2(3), ACSM1(4), AKR1B10(2), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH5A1(5), ALDH9A1(3), BDH1(4), DDHD1(9), EHHADH(6), GAD1(6), GAD2(7), HADH(3), HADHA(4), HMGCS1(1), HMGCS2(3), HSD17B4(4), HSD3B7(4), ILVBL(3), L2HGDH(1), OXCT1(6), OXCT2(1), PDHA1(1), PDHA2(4), PDHB(3), PLA1A(2), PRDX6(1), RDH11(1), RDH12(1), RDH13(3) 13313100 142 68 139 60 47 37 2 39 17 0 0.753 1.000 1.000 373 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(5), AZIN1(1), CLDN5(2), CLOCK(3), CRY1(3), CRY2(4), DAZAP2(7), DNAJA1(3), EIF4G2(5), ETV6(3), G0S2(2), GFRA1(8), GSTM3(2), HERPUD1(1), HSPA8(4), KLF9(2), MYF6(3), NCKAP1(8), NCOA4(4), NR1D2(5), PER1(5), PER2(9), PPP1R3C(3), PPP2CB(2), PSMA4(4), PURA(1), SF3A3(3), SUMO3(1), TOB1(1), TUBB3(12), UCP3(2), UGP2(3), VAPA(1), ZFR(8) 11973853 130 67 129 45 41 38 4 37 10 0 0.314 1.000 1.000 374 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(4), AARS2(10), ABAT(4), ACY3(1), ADSL(3), ADSS(4), ADSSL1(7), AGXT(1), AGXT2(7), ASL(5), ASNS(3), ASPA(1), ASRGL1(2), ASS1(7), CAD(12), CRAT(1), DARS(2), DARS2(1), DDO(4), DLAT(3), DLD(3), GAD1(6), GAD2(7), GOT1(2), GOT2(2), GPT(1), GPT2(2), NARS(4), PC(7), PDHA1(1), PDHA2(4), PDHB(3) 12399584 124 67 122 58 48 39 1 29 7 0 0.857 1.000 1.000 375 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(19), ACACB(22), ACAT1(3), ACAT2(3), ACOT12(5), ACSS1(9), ACSS2(6), ACYP1(1), ACYP2(3), AKR1B1(6), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), DLAT(3), DLD(3), GLO1(1), GRHPR(2), HAGH(2), LDHA(3), LDHAL6B(4), LDHB(4), LDHC(1), LDHD(3), MDH1(3), ME1(1), ME2(4), ME3(4), PC(7), PCK1(6), PCK2(7), PDHA1(1), PDHA2(4), PDHB(3), PKLR(5), PKM2(5) 15350589 181 67 179 62 55 56 6 41 23 0 0.212 1.000 1.000 376 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(4), AARS2(10), CARS(4), CARS2(5), DARS(2), DARS2(1), EARS2(3), EPRS(7), FARS2(6), FARSA(1), FARSB(1), GARS(1), HARS(5), HARS2(2), IARS(9), IARS2(7), KARS(5), LARS(4), LARS2(7), MARS(4), MARS2(1), MTFMT(1), NARS(4), QARS(3), RARS(4), RARS2(3), SARS(4), SARS2(6), TARS(6), TARS2(5), VARS(10), VARS2(9), WARS(3), WARS2(7), YARS(3), YARS2(3) 17826650 160 67 159 57 55 49 7 38 11 0 0.435 1.000 1.000 377 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(2), ALOX12(3), ALOX15(3), ALOX5(6), CBR1(1), CBR3(3), CYP4F2(8), CYP4F3(7), EPX(6), GGT1(4), LPO(7), LTA4H(4), MPO(6), PLA2G2A(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(1), PTGDS(1), PTGES2(3), PTGIS(5), PTGS1(7), PTGS2(5), TBXAS1(2), TPO(15) 9135694 126 67 124 38 42 25 8 36 15 0 0.110 1.000 1.000 378 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA2(4), ACADL(2), ACADM(4), ACADS(3), ACADSB(5), ACADVL(1), ACAT1(3), ACAT2(3), ACOX1(4), ACOX3(8), ACSL1(2), ACSL3(6), ACSL4(2), ACSL5(5), ACSL6(5), ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH5(3), ADH6(5), ADH7(1), ADHFE1(8), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), CPT1A(7), CPT1B(3), CPT1C(6), CPT2(5), CYP4A11(2), CYP4A22(2), DCI(2), EHHADH(6), GCDH(5), HADH(3), HADHA(4), HADHB(4), HSD17B4(4), PECI(1) 16084841 166 66 163 52 44 49 6 44 23 0 0.0808 1.000 1.000 379 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(4), ARG1(2), ASL(5), ASS1(7), CKB(1), CKMT1A(3), CKMT1B(1), CKMT2(6), CPS1(18), DAO(8), EPRS(7), GATM(3), GLUD1(3), GLUD2(10), GOT1(2), GOT2(2), LAP3(1), NOS1(22), NOS3(5), OTC(2), P4HA1(3), P4HA2(8), P4HA3(4), PYCR1(3), PYCRL(1), RARS(4), RARS2(3) 11767967 138 66 137 43 53 38 8 32 7 0 0.0850 1.000 1.000 380 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(2), ACTR3(2), ARHGAP1(1), ARHGAP4(4), ARHGAP5(11), ARHGAP6(6), ARHGEF1(9), ARHGEF11(12), ARHGEF5(4), ARPC1A(3), ARPC2(1), ARPC4(2), BAIAP2(4), CFL1(1), DIAPH1(7), GSN(9), LIMK1(3), MYL2(6), MYLK(15), OPHN1(6), PIP5K1A(3), PIP5K1B(1), PPP1R12B(12), ROCK1(9), SRC(2), TLN1(14), VCL(1) 14894981 150 65 148 56 49 45 8 30 16 2 0.508 1.000 1.000 381 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(1), BCR(9), BLNK(3), ELK1(3), FOS(1), GRB2(4), JUN(3), LYN(4), MAP2K1(5), MAP3K1(9), MAPK1(2), MAPK3(1), MAPK8IP3(10), PAPPA(19), RPS6KA1(6), RPS6KA3(3), SHC1(3), SOS1(6), SYK(6), VAV1(6), VAV2(11), VAV3(10) 10510062 125 65 121 53 40 36 3 32 14 0 0.678 1.000 1.000 382 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(16), CD3E(2), CD4(5), CREBBP(26), CSK(5), GNAS(20), GNGT1(3), HLA-DRA(6), LCK(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PTPRC(15), ZAP70(10) 7530408 133 64 130 59 47 43 2 25 16 0 0.795 1.000 1.000 383 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(16), CD3E(2), CD4(5), CREBBP(26), CSK(5), GNAS(20), GNGT1(3), HLA-DRA(6), LCK(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PTPRC(15), ZAP70(10) 7530408 133 64 130 59 47 43 2 25 16 0 0.795 1.000 1.000 384 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(11), ELK1(3), GNAS(20), GNGT1(3), GRB2(4), IGF1R(15), ITGB1(6), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK3(1), MKNK1(3), MKNK2(1), MYC(3), NGFR(4), PDGFRA(11), PPP2CA(3), PTPRR(7), RAF1(7), RPS6KA1(6), RPS6KA5(2), SHC1(3), SOS1(6), SRC(2), STAT3(6) 10848402 136 64 130 62 48 40 0 39 9 0 0.887 1.000 1.000 385 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(4), ALDH4A1(4), ALDH5A1(5), CAD(12), CPS1(18), EPRS(7), GAD1(6), GAD2(7), GCLC(1), GCLM(2), GFPT1(3), GLS(8), GLS2(6), GLUD1(3), GLUL(5), GMPS(4), GOT1(2), GOT2(2), GPT(1), GPT2(2), GSS(3), NADSYN1(4), PPAT(3), QARS(3) 10898744 115 64 114 47 37 39 3 29 7 0 0.695 1.000 1.000 386 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(5), AKR1D1(2), ARSD(4), ARSE(4), CARM1(2), CYP11B1(7), CYP11B2(4), CYP19A1(9), HEMK1(1), HSD11B1(2), HSD11B2(2), HSD17B1(4), HSD17B12(2), HSD17B2(2), HSD17B3(1), HSD17B7(2), HSD3B1(1), HSD3B2(3), LCMT1(1), LCMT2(7), METTL6(2), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(4), PRMT8(3), SRD5A1(3), SRD5A2(3), STS(4), SULT1E1(2), SULT2A1(3), UGT1A1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A5(8), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2A1(3), UGT2A3(3), UGT2B10(8), UGT2B11(2), UGT2B15(2), UGT2B28(5), UGT2B4(3), UGT2B7(3), WBSCR22(4) 16443905 150 64 149 56 39 55 6 33 17 0 0.288 1.000 1.000 387 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B4GALT5(5), C1GALT1(3), C1GALT1C1(4), GALNT1(2), GALNT10(5), GALNT11(4), GALNT12(1), GALNT13(7), GALNT14(6), GALNT2(4), GALNT3(2), GALNT4(2), GALNT5(7), GALNT6(2), GALNT8(5), GALNT9(2), GALNTL1(7), GALNTL2(7), GALNTL4(7), GALNTL5(3), GCNT3(2), GCNT4(2), OGT(2), ST3GAL1(4), ST3GAL2(4), ST6GALNAC1(2), WBSCR17(22) 10604890 123 64 120 51 45 32 7 31 8 0 0.748 1.000 1.000 388 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(2), ALOX12(3), ALOX12B(8), ALOX15(3), ALOX15B(3), ALOX5(6), CBR1(1), CBR3(3), CYP2B6(6), CYP2C18(3), CYP2C19(7), CYP2C8(1), CYP2E1(4), CYP2J2(4), CYP2U1(5), CYP4A11(2), CYP4A22(2), CYP4F2(8), CYP4F3(7), EPHX2(3), GGT1(4), GPX1(1), GPX2(1), GPX3(1), GPX5(1), GPX6(3), GPX7(3), LTA4H(4), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(1), PLA2G2D(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), PTGDS(1), PTGES2(3), PTGIS(5), PTGS1(7), PTGS2(5), TBXAS1(2) 12750712 151 64 149 43 49 40 5 41 16 0 0.0299 1.000 1.000 389 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(1), CALM2(3), DLG4(3), GRIN1(4), GRIN2A(11), GRIN2B(18), GRIN2C(4), GRIN2D(4), NOS1(22), PPP3CA(5), PPP3CB(6), PPP3CC(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKCA(3), SYT1(3) 8368958 112 64 112 52 44 28 3 23 14 0 0.751 1.000 1.000 390 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(2), ELK1(3), FOS(1), IKBKB(7), IRAK1(5), JUN(3), LY96(1), MAP2K3(7), MAP2K4(7), MAP2K6(1), MAP3K1(9), MAP3K14(3), MAP3K7(8), MAPK14(1), MAPK8(5), MYD88(1), NFKB1(7), NFKBIA(1), PPARA(3), RELA(3), TIRAP(1), TLR10(6), TLR2(1), TLR3(5), TLR4(18), TLR6(1), TLR7(5), TLR9(13), TOLLIP(2), TRAF6(5) 11960756 135 64 129 52 39 34 8 32 22 0 0.497 1.000 1.000 391 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(3), AGTR1(1), ATF2(1), CALM1(1), CALM2(3), EGFR(11), ELK1(3), GNAQ(3), GRB2(4), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K4(7), MAP3K1(9), MAPK1(2), MAPK3(1), MAPK8(5), MEF2B(4), MEF2C(3), MEF2D(6), PAK1(5), PRKCA(3), PTK2(10), PTK2B(10), RAF1(7), SHC1(3), SOS1(6), SRC(2), SYT1(3) 10994905 126 63 121 44 46 30 7 26 17 0 0.272 1.000 1.000 392 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(5), ALG10(6), ALG10B(3), ALG12(3), ALG13(7), ALG14(1), ALG3(2), ALG5(2), ALG6(2), ALG8(1), ALG9(1), B4GALT1(2), B4GALT2(5), B4GALT3(2), DHDDS(3), DOLPP1(2), DPAGT1(1), DPM1(1), FUT8(3), GANAB(4), MAN1A1(2), MAN1A2(3), MAN1B1(5), MAN1C1(2), MAN2A1(3), MGAT1(2), MGAT2(2), MGAT3(5), MGAT4A(2), MGAT4B(2), MGAT5(8), MGAT5B(4), RFT1(3), RPN1(2), RPN2(3), STT3B(3) 13892080 107 63 106 57 34 30 7 18 17 1 0.963 1.000 1.000 393 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(5), ARSB(2), FUCA1(1), FUCA2(1), GALNS(1), GBA(6), GLB1(2), GNS(3), GUSB(8), HEXA(2), HEXB(2), HGSNAT(3), HPSE(6), HPSE2(2), HYAL1(4), HYAL2(4), IDS(3), IDUA(2), LCT(15), MAN2B1(10), MAN2B2(12), MAN2C1(7), MANBA(5), NAGLU(3), NEU1(1), NEU2(3), NEU3(4), NEU4(1), SPAM1(8) 11267026 126 62 124 44 45 43 7 20 11 0 0.201 1.000 1.000 394 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(2), GTF2B(2), GTF2E1(4), GTF2E2(2), GTF2F1(5), GTF2F2(1), GTF2H1(1), GTF2H3(2), GTF2H4(3), GTF2I(6), GTF2IRD1(11), TAF1(13), TAF10(1), TAF13(1), TAF1L(19), TAF2(8), TAF4(10), TAF4B(3), TAF5(2), TAF5L(3), TAF6(8), TAF6L(4), TAF7(5), TAF7L(3), TAF9B(3), TBPL1(2), TBPL2(5) 11829191 129 62 126 34 37 37 9 27 19 0 0.0330 1.000 1.000 395 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(5), ADRBK2(5), CALM1(1), CALM2(3), CALML3(1), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CLCA1(8), CLCA2(5), CLCA4(7), CNGA3(7), CNGA4(17), CNGB1(10), GNAL(2), GUCA1A(2), GUCA1B(2), GUCA1C(3), PDC(1), PDE1C(5), PRKACA(3), PRKACB(2), PRKACG(5), PRKG1(8), PRKG2(10), PRKX(4) 10020003 128 62 123 47 49 30 4 33 12 0 0.292 1.000 1.000 396 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(4), CALM1(1), CALM2(3), CRKL(1), GNAQ(3), GRB2(4), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K3(7), MAP2K4(7), MAP3K1(9), MAPK1(2), MAPK14(1), MAPK3(1), MAPK8(5), PAK1(5), PLCG1(16), PRKCA(3), PTK2B(10), RAF1(7), SHC1(3), SOS1(6), SRC(2), SYT1(3) 9329121 113 62 107 32 40 30 4 25 14 0 0.0750 1.000 1.000 397 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(1), CALM2(3), EGR2(6), EGR3(5), GNAQ(3), MAP3K1(9), MYC(3), NFATC1(11), NFATC2(14), NFKB1(7), NFKBIA(1), PLCG1(16), PPP3CA(5), PPP3CB(6), PPP3CC(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), RELA(3), SYT1(3), VIP(3), VIPR2(3) 9170775 127 62 123 39 49 34 2 25 17 0 0.0574 1.000 1.000 398 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(16), EXT2(5), EXTL1(4), EXTL2(2), EXTL3(10), GLCE(3), HS2ST1(2), HS3ST1(2), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(3), HS3ST5(6), HS6ST1(2), HS6ST2(4), HS6ST3(6), NDST1(10), NDST2(6), NDST3(10), NDST4(13) 6771461 114 61 111 34 37 33 4 31 9 0 0.153 1.000 1.000 399 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(5), BAIAP2(4), CASP1(2), CASP3(2), CASP7(2), CASP8(8), GAPDH(1), INSR(12), ITCH(4), MAGI1(14), MAGI2(23), RERE(17), WWP1(9), WWP2(10) 7867633 113 61 107 36 30 29 7 23 24 0 0.271 1.000 1.000 400 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG2(7), ADCY3(5), ADCY9(8), AK1(1), ARF1(4), ARF4(1), ARL4D(1), ATP6V0A1(4), ATP6V0A2(5), ATP6V0A4(6), ATP6V0B(2), ATP6V0D1(6), ATP6V1A(5), ATP6V1C1(2), ATP6V1C2(6), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(5), ERO1L(1), GNAS(20), PDIA4(1), PLCG1(16), PLCG2(11), PRKCA(3), SEC61A1(3), SEC61B(1), SEC61G(1), TRIM23(3) 12143535 135 61 131 56 54 32 5 33 11 0 0.672 1.000 1.000 401 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(11), ATP4B(1), ATP6AP1(5), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(2), ATP6V0D1(6), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(6), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(5), ATP7A(8), ATP7B(11), COX10(1), COX4I1(3), COX6B1(2), COX7A2(1), COX7C(1), NDUFA1(1), NDUFA10(1), NDUFA8(5), NDUFB2(1), NDUFB4(1), NDUFB5(1), NDUFB6(1), NDUFB7(1), NDUFS1(6), NDUFS2(2), NDUFV1(2), PPA2(3), SDHA(6), SDHB(4), SHMT1(1), UQCRB(1), UQCRC1(2), UQCRFS1(1) 12526073 140 61 138 56 46 43 6 31 14 0 0.600 1.000 1.000 402 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BAD(3), BRAF(9), CREB1(3), CREB3(4), CREB5(4), DUSP6(3), DUSP9(3), EEF2K(7), EIF4E(2), GRB2(4), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK3(1), MKNK1(3), MKNK2(1), MOS(9), NFKB1(7), RAP1A(2), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3), SHC1(3), SOS1(6), SOS2(11), TRAF3(3) 9672183 114 61 110 46 35 31 2 30 16 0 0.655 1.000 1.000 403 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP2(2), ACP5(1), ACPP(2), ACPT(4), ALPI(6), ALPL(4), ALPP(7), ALPPL2(6), CYP19A1(9), CYP1A1(4), CYP1A2(4), CYP2A13(7), CYP2A6(5), CYP2A7(5), CYP2B6(6), CYP2C18(3), CYP2C19(7), CYP2C8(1), CYP2D6(4), CYP2E1(4), CYP2F1(5), CYP2J2(4), CYP3A4(2), CYP3A7(4), CYP4B1(7), CYP4F8(2), CYP51A1(6), PON1(2) 9619453 123 60 121 43 51 30 4 27 11 0 0.246 1.000 1.000 404 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(4), ACAA2(4), ACADM(4), ACADS(3), ACAT1(3), ACAT2(3), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH6A1(4), ALDH9A1(3), AOX1(7), AUH(7), BCAT1(3), BCAT2(5), BCKDHA(5), BCKDHB(1), DBT(2), DLD(3), EHHADH(6), HADH(3), HADHA(4), HADHB(4), HIBADH(3), HMGCS1(1), HMGCS2(3), HSD17B4(4), IVD(4), MCCC1(3), MCCC2(3), MCEE(2), MUT(3), OXCT1(6), OXCT2(1), PCCA(8), PCCB(4) 14129026 148 60 143 53 38 50 3 31 25 1 0.401 1.000 1.000 405 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(9), ACY3(1), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH3B1(3), ALDH3B2(7), ALDH9A1(3), AOC2(4), AOC3(4), ASPA(1), CARM1(2), CNDP1(1), DDC(5), FTCD(2), HAL(1), HARS(5), HARS2(2), HDC(7), HEMK1(1), HNMT(2), LCMT1(1), LCMT2(7), MAOA(1), MAOB(3), METTL6(2), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(4), PRMT8(3), PRPS1(2), PRPS2(2), UROC1(8), WBSCR22(4) 12993177 131 60 131 42 40 37 6 34 14 0 0.144 1.000 1.000 406 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(3), ARSD(4), ARSE(4), ASAH1(2), B4GALT6(2), CERK(5), DEGS1(2), DEGS2(1), ENPP7(5), GAL3ST1(6), GALC(5), GBA(6), GLB1(2), LCT(15), NEU1(1), NEU2(3), NEU3(4), NEU4(1), PPAP2A(1), PPAP2C(4), SGMS1(2), SGMS2(2), SGPP1(1), SGPP2(1), SMPD1(5), SMPD2(1), SMPD3(9), SMPD4(7), SPHK1(4), SPHK2(2), SPTLC1(1), SPTLC2(3), UGCG(3), UGT8(4) 11697205 121 60 120 46 50 38 5 16 12 0 0.275 1.000 1.000 407 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), DAG1(8), ITPKA(1), ITPKB(7), ITPR1(21), ITPR2(20), ITPR3(30), NFAT5(9), PDE6A(4), PDE6B(8), PDE6C(3), PDE6G(1), SLC6A13(5), TF(6) 11741959 135 60 134 58 57 33 8 27 9 1 0.543 1.000 1.000 408 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(6), ACTN2(22), ACTN3(2), BCAR1(4), CSK(5), CTNNA1(11), CTNNA2(16), CTNNB1(16), PTK2(10), PXN(3), SRC(2), VCL(1) 6259481 98 59 96 42 32 23 7 26 10 0 0.731 1.000 1.000 409 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(3), ALDOC(3), DLAT(3), DLD(3), ENO1(2), ENO2(3), ENO3(4), FBP1(2), FBP2(4), GAPDH(1), GAPDHS(3), GCK(4), GOT1(2), GOT2(2), GPI(5), HK1(11), HK2(8), HK3(5), LDHA(3), LDHAL6B(4), LDHB(4), LDHC(1), MDH1(3), PC(7), PCK1(6), PDHA1(1), PDHA2(4), PDHB(3), PDHX(2), PFKL(4), PFKM(3), PFKP(8), PGAM2(4), PGK1(4), PGK2(2), PKLR(5), PKM2(5), TNFAIP1(4), TPI1(1) 13937519 146 59 144 68 57 45 3 33 8 0 0.782 1.000 1.000 410 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(6), AKR1B10(2), B4GALT1(2), B4GALT2(5), G6PC2(1), GAA(2), GALE(1), GALK1(2), GALK2(2), GALT(1), GANC(7), GCK(4), GLB1(2), HK1(11), HK2(8), HK3(5), HSD3B7(4), LALBA(1), LCT(15), MGAM(9), PFKL(4), PFKM(3), PFKP(8), PGM1(2), PGM3(10), RDH11(1), RDH12(1), RDH13(3), UGP2(3) 12646519 125 59 124 61 51 39 2 24 9 0 0.849 1.000 1.000 411 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(5), AASDH(5), AASS(6), ACAT1(3), ACAT2(3), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), BBOX1(3), DLST(4), DOT1L(8), EHHADH(6), EHMT1(10), EHMT2(6), GCDH(5), HADHA(4), PLOD1(7), PLOD2(6), PLOD3(8), SDS(2), SHMT1(1), SHMT2(5), TMLHE(5) 12112794 138 59 136 51 44 47 2 24 21 0 0.253 1.000 1.000 412 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(1), CDC42(1), CREB1(3), DAXX(9), DDIT3(3), ELK1(3), GRB2(4), MAP2K4(7), MAP2K6(1), MAP3K1(9), MAP3K5(4), MAP3K7(8), MAP3K9(3), MAPK14(1), MAPKAPK2(1), MAPKAPK5(1), MAX(3), MEF2B(4), MEF2C(3), MEF2D(6), MKNK1(3), MYC(3), PLA2G4A(4), RIPK1(1), RPS6KA5(2), SHC1(3), STAT1(7), TGFB1(3), TGFB2(6), TGFB3(5), TGFBR1(5), TRADD(2), TRAF2(2) 12026493 121 59 118 41 36 35 5 21 24 0 0.278 1.000 1.000 413 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(7), GTF2A1(2), GTF2B(2), GTF2E1(4), GTF2F1(5), HDAC3(4), NCOA1(12), NCOA2(21), NCOA3(11), NCOR2(21), POLR2A(15), RARA(2), RXRA(3), TBP(2) 8158428 111 59 110 41 31 42 3 24 11 0 0.379 1.000 1.000 414 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(7), DYRK1B(7), GLI2(11), GLI3(33), GSK3B(4), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), SHH(4), SMO(10), SUFU(5) 5437712 103 59 103 42 42 22 4 28 7 0 0.405 1.000 1.000 415 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(1), CCR3(6), CFL1(1), GNAQ(3), GNAS(20), GNGT1(3), LIMK1(3), MAP2K1(5), MAPK1(2), MAPK3(1), MYL2(6), NOX1(4), PIK3C2G(7), PLCB1(13), PPP1R12B(12), PRKCA(3), PTK2(10), RAF1(7), ROCK2(7) 8273506 114 58 110 32 42 23 4 29 16 0 0.201 1.000 1.000 416 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(4), ALAS1(2), ALAS2(9), BLVRA(3), COX10(1), COX15(5), CP(9), CPOX(2), EARS2(3), EPRS(7), FECH(6), FTH1(3), FTMT(3), GUSB(8), HCCS(1), HMBS(2), HMOX1(5), HMOX2(1), MMAB(2), PPOX(2), UGT1A1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A5(8), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2A1(3), UGT2A3(3), UGT2B10(8), UGT2B11(2), UGT2B15(2), UGT2B28(5), UGT2B4(3), UGT2B7(3), UROD(1), UROS(3) 13808126 130 58 130 55 30 44 6 38 12 0 0.766 1.000 1.000 417 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(2), CAPN1(2), CAPN2(3), CAPNS1(2), CAPNS2(2), EGF(8), EGFR(11), ITGA1(7), ITGB1(6), MAPK1(2), MAPK3(1), MYL2(6), MYLK(15), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PTK2(10), PXN(3), TLN1(14) 10719086 116 58 114 53 44 31 7 24 10 0 0.711 1.000 1.000 418 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(26), DUSP1(2), EP300(19), IKBKB(7), IL1B(2), IL8(1), MAP2K3(7), MAP2K6(1), MAP3K14(3), MAP3K7(8), MAPK11(1), MAPK14(1), MYD88(1), NFKB1(7), NFKBIA(1), NR3C1(5), RELA(3), TGFBR1(5), TGFBR2(11), TLR2(1), TNF(1) 9714449 113 58 112 37 31 34 8 21 19 0 0.249 1.000 1.000 419 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(19), ACAT1(3), ACAT2(3), ACYP1(1), ACYP2(3), ADH5(3), AKR1B1(6), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), DLAT(3), DLD(3), GLO1(1), GRHPR(2), HAGH(2), LDHA(3), LDHB(4), LDHC(1), LDHD(3), MDH1(3), ME1(1), ME2(4), ME3(4), PC(7), PCK1(6), PDHA1(1), PDHA2(4), PDHB(3), PKLR(5), PKM2(5) 12121292 139 58 137 53 43 48 3 29 16 0 0.479 1.000 1.000 420 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(4), ABP1(9), ACADL(2), ACADM(4), ACADSB(5), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), AOC2(4), AOC3(4), CNDP1(1), DPYD(12), DPYS(7), EHHADH(6), GAD1(6), GAD2(7), HADHA(4), MLYCD(5), SDS(2), SMS(3), UPB1(2) 9540105 123 57 119 40 35 41 4 32 11 0 0.130 1.000 1.000 421 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(9), ABAT(4), ACADS(3), ACAT1(3), ACAT2(3), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH5A1(5), ALDH9A1(3), EHHADH(6), GAD1(6), GAD2(7), HADHA(4), L2HGDH(1), OXCT1(6), PDHA1(1), PDHA2(4), PDHB(3), SDHB(4), SDS(2) 8462762 107 57 105 45 36 32 0 26 13 0 0.681 1.000 1.000 422 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA2(4), ACAD8(3), ACAD9(5), ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH5(3), ADH6(5), ADH7(1), ADHFE1(8), AKR1B10(2), AKR1C4(5), AKR1D1(2), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), BAAT(1), CEL(7), CYP27A1(4), CYP7A1(4), HADHB(4), HSD3B7(4), LIPA(1), RDH11(1), RDH12(1), RDH13(3), SLC27A5(4), SOAT1(6), SOAT2(2), SRD5A1(3), SRD5A2(3) 10386794 124 57 122 39 31 43 5 30 15 0 0.109 1.000 1.000 423 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(4), ACACA(19), ACACB(22), ACADM(4), ACAT1(3), ACAT2(3), ACSS1(9), ACSS2(6), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH6A1(4), ALDH9A1(3), EHHADH(6), HADHA(4), LDHA(3), LDHAL6B(4), LDHB(4), LDHC(1), MCEE(2), MLYCD(5), MUT(3), PCCA(8), PCCB(4), SUCLA2(4), SUCLG1(2), SUCLG2(2) 13039588 154 57 149 43 41 46 4 38 25 0 0.0526 1.000 1.000 424 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(8), ANAPC10(1), ANAPC11(1), ANAPC2(4), ANAPC5(2), ANAPC7(3), BTRC(4), CDC16(4), CDC20(4), CDC23(4), CDC26(1), CDC27(2), CUL1(14), CUL2(5), CUL3(5), FBXW11(10), FBXW7(20), FZR1(3), ITCH(4), RBX1(1), SKP2(5), SMURF1(3), SMURF2(3), TCEB1(1), UBA1(2), UBE2D3(2), UBE2E3(3), WWP1(9), WWP2(10) 13200951 138 57 128 36 54 44 1 21 18 0 0.0226 1.000 1.000 425 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(2), ERCC3(7), GTF2B(2), GTF2E1(4), GTF2E2(2), GTF2F2(1), GTF2H1(1), GTF2H4(3), ILK(3), MNAT1(2), POLR1A(12), POLR1B(4), POLR2A(15), POLR2B(9), POLR2C(2), POLR2E(2), POLR2F(1), POLR2G(1), POLR2I(1), POLR2K(1), POLR3B(7), POLR3D(4), POLR3E(3), POLR3K(1), TAF13(1), TAF5(2), TAF6(8), TAF7(5), TBP(2) 11501047 108 57 107 38 40 34 2 20 12 0 0.348 1.000 1.000 426 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(6), AKR1B10(2), ALDOB(3), ALDOC(3), FBP1(2), FBP2(4), FPGT(3), FUK(3), GMDS(2), GMPPA(6), GMPPB(2), HK1(11), HK2(8), HK3(5), HSD3B7(4), KHK(2), LHPP(3), MPI(3), MTMR1(4), MTMR2(3), MTMR6(5), PFKFB1(2), PFKFB2(5), PFKFB3(3), PFKFB4(3), PFKL(4), PFKM(3), PFKP(8), PGM2(1), PHPT1(2), PMM1(2), PMM2(2), RDH11(1), RDH12(1), RDH13(3), SORD(2), TPI1(1), TSTA3(6) 12181843 133 56 133 46 52 43 2 26 10 0 0.133 1.000 1.000 427 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(2), DLG4(3), EPHB2(8), F2(5), F2RL1(2), F2RL2(2), F2RL3(1), JUN(3), MAP2K5(1), MAPK1(2), MAPK7(7), MAPK8(5), MYEF2(9), PLD1(13), PLD2(13), PLD3(4), PTK2(10), RAF1(7), RASAL1(4), SRC(2), TEC(4), VAV1(6) 8978757 113 56 112 30 38 34 6 20 15 0 0.0291 1.000 1.000 428 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(28), MAP2(23), PPP1CA(2), PPP2CA(3), PRKACB(2), PRKACG(5), PRKAG1(3), PRKAR2A(2), PRKAR2B(7), PRKCE(8) 5961212 83 55 82 29 14 29 2 27 11 0 0.526 1.000 1.000 429 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(5), BCL2(2), BID(2), BIRC2(3), BIRC3(3), CASP10(5), CASP3(2), CASP6(1), CASP7(2), CASP8(8), CASP9(2), DFFA(4), DFFB(3), GAS2(2), LMNA(3), MAP3K14(3), NFKB1(7), NFKBIA(1), RELA(3), RIPK1(1), SPTAN1(18), TNFRSF10A(1), TNFRSF10B(2), TNFRSF25(4), TNFSF10(3), TRADD(2), TRAF2(2) 10941157 94 55 92 31 26 24 2 28 14 0 0.459 1.000 1.000 430 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IFNA1(1), IFNB1(2), IKBKB(7), IL1A(2), IL1B(2), IL1R1(4), IL1RAP(5), IL1RN(1), IRAK1(5), IRAK2(8), IRAK3(4), JUN(3), MAP2K3(7), MAP2K6(1), MAP3K1(9), MAP3K14(3), MAP3K7(8), MAPK14(1), MAPK8(5), MYD88(1), NFKB1(7), NFKBIA(1), RELA(3), TGFB1(3), TGFB2(6), TGFB3(5), TNF(1), TOLLIP(2), TRAF6(5) 9724136 112 55 109 37 34 29 6 26 17 0 0.305 1.000 1.000 431 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(6), B4GALT1(2), B4GALT2(5), FBP2(4), GAA(2), GALE(1), GALK1(2), GALK2(2), GALT(1), GANAB(4), GCK(4), GLB1(2), HK1(11), HK2(8), HK3(5), LALBA(1), LCT(15), MGAM(9), PFKM(3), PFKP(8), PGM1(2), PGM3(10) 10668999 107 54 106 53 45 30 2 19 11 0 0.866 1.000 1.000 432 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(4), ACO1(8), ACO2(5), CLYBL(1), CS(2), DLD(3), DLST(4), FH(2), IDH1(1), IDH2(1), IDH3A(1), IDH3B(2), IDH3G(3), MDH1(3), OGDH(7), OGDHL(10), PC(7), PCK1(6), PCK2(7), SDHA(6), SDHB(4), SDHC(1), SUCLA2(4), SUCLG1(2), SUCLG2(2) 9815813 96 54 92 37 44 23 5 11 13 0 0.406 1.000 1.000 433 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(4), ABP1(9), ACADM(4), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), AOC2(4), AOC3(4), CNDP1(1), DPYD(12), DPYS(7), EHHADH(6), GAD1(6), GAD2(7), HADHA(4), MLYCD(5), SMS(3), SRM(1), UPB1(2) 8861538 107 54 103 33 31 34 4 28 10 0 0.0968 1.000 1.000 434 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(5), POLA2(3), POLB(2), POLD1(10), POLD2(1), POLD3(3), POLE(17), POLE2(3), POLE3(1), POLG(5), POLG2(4), POLH(5), POLI(1), POLK(6), POLL(2), POLM(3), POLQ(22), PRIM1(2), PRIM2(6), REV1(7), REV3L(23), RFC5(1) 13329313 132 54 132 52 38 36 5 30 23 0 0.733 1.000 1.000 435 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(3), CDC42(1), CREB1(3), CREB3(4), CREB5(4), DUSP1(2), DUSP10(6), EEF2K(7), EIF4E(2), ELK1(3), IL1R1(4), MAP2K3(7), MAP2K4(7), MAP2K6(1), MAP3K10(8), MAP3K4(15), MAP3K5(4), MAP3K7(8), MAPK1(2), MAPK11(1), MAPK13(1), MAPK14(1), MAPKAPK2(1), MAPKAPK5(1), MKNK1(3), MKNK2(1), MYEF2(9), NFKB1(7), NR2C2(2), SRF(1), TRAF6(5) 10922282 124 54 123 42 35 42 10 20 17 0 0.141 1.000 1.000 436 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(2), CDK5R1(1), CSNK1D(2), DRD1(3), DRD2(7), GRM1(26), PLCB1(13), PPP1CA(2), PPP1R1B(1), PPP2CA(3), PPP3CA(5), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7) 5251638 87 53 85 33 30 25 1 20 11 0 0.444 1.000 1.000 437 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(3), ASNS(3), ASRGL1(2), CA13(3), CA14(3), CA2(1), CA3(3), CA4(3), CA5B(1), CA6(3), CA7(3), CA8(3), CA9(4), CPS1(18), CTH(2), GLS(8), GLS2(6), GLUD1(3), GLUD2(10), GLUL(5), HAL(1) 6974059 88 53 88 35 21 31 3 26 7 0 0.647 1.000 1.000 438 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(2), EGF(8), EGFR(11), GRB2(4), MAP2K1(5), MAPK1(2), MAPK3(1), PTPRB(17), RAF1(7), RASA1(11), SHC1(3), SOS1(6), SPRY1(2), SPRY3(6), SPRY4(4), SRC(2) 8197714 91 53 88 33 26 22 2 32 9 0 0.615 1.000 1.000 439 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(2), ADCY1(16), CAP1(3), CCNB1(3), CDC25C(7), GNAI1(1), GNAS(20), GNGT1(3), MAPK1(2), MAPK3(1), MYT1(14), PIN1(1), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), RPS6KA1(6), SRC(2) 6741430 103 52 101 44 40 26 1 26 10 0 0.722 1.000 1.000 440 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(11), ARHGEF1(9), GNA12(1), GNA13(3), GNAQ(3), GNGT1(3), MYL2(6), MYLK(15), PLCB1(13), PPP1R12B(12), PRKCA(3), ROCK1(9) 6794253 88 52 86 29 24 23 2 23 14 2 0.471 1.000 1.000 441 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 IKBKB(7), IL1A(2), IL1R1(4), IRAK1(5), MAP3K1(9), MAP3K14(3), MAP3K7(8), MYD88(1), NFKB1(7), NFKBIA(1), RELA(3), RIPK1(1), TLR4(18), TNF(1), TNFAIP3(5), TNFRSF1A(3), TNFRSF1B(1), TRADD(2), TRAF6(5) 7959028 86 52 82 30 24 20 5 24 13 0 0.438 1.000 1.000 442 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(4), ACACA(19), ACADL(2), ACADM(4), ACADSB(5), ACAT1(3), ACAT2(3), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH6A1(4), ALDH9A1(3), EHHADH(6), HADHA(4), LDHA(3), LDHB(4), LDHC(1), MCEE(2), MLYCD(5), MUT(3), PCCA(8), PCCB(4), SDS(2), SUCLA2(4), SUCLG1(2), SUCLG2(2) 10874139 130 52 125 38 34 46 1 29 20 0 0.130 1.000 1.000 443 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(2), ANXA2(1), ANXA4(3), ANXA5(1), ANXA6(2), CYP11A1(4), EDN1(2), EDNRA(3), EDNRB(20), HSD11B1(2), HSD11B2(2), PLA2G4A(4), PRL(1), PTGDR(6), PTGDS(1), PTGER2(4), PTGER4(4), PTGFR(3), PTGIS(5), PTGS1(7), PTGS2(5), S100A6(1), TBXAS1(2) 6779323 85 52 82 40 24 21 5 25 10 0 0.919 1.000 1.000 444 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(5), F2R(2), F2RL3(1), GNAI1(1), GNGT1(3), ITGA1(7), ITGB1(6), MAP2K1(5), MAPK1(2), MAPK3(1), PLA2G4A(4), PLCB1(13), PRKCA(3), PTGS1(7), PTK2(10), RAF1(7), SRC(2), SYK(6), TBXAS1(2) 7991998 87 52 83 36 28 21 6 21 11 0 0.653 1.000 1.000 445 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(6), ALDOB(3), ALDOC(3), FBP1(2), FBP2(4), FPGT(3), GCK(4), GMDS(2), GMPPA(6), GMPPB(2), HK1(11), HK2(8), HK3(5), KHK(2), MPI(3), PFKFB1(2), PFKFB3(3), PFKFB4(3), PFKM(3), PFKP(8), PMM1(2), PMM2(2), SORD(2), TPI1(1) 7856467 90 51 90 31 41 24 1 18 6 0 0.157 1.000 1.000 446 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(2), CHIA(4), CHIT1(3), CMAS(4), CTBS(2), CYB5R1(1), CYB5R3(1), GFPT1(3), GFPT2(4), GNE(5), GNPDA1(3), GNPDA2(2), GNPNAT1(2), HEXA(2), HEXB(2), HK1(11), HK2(8), HK3(5), LHPP(3), MTMR1(4), MTMR2(3), MTMR6(5), NANS(1), NPL(2), PGM3(10), PHPT1(2), RENBP(2), UAP1(3) 9415778 99 51 99 32 27 35 4 25 8 0 0.179 1.000 1.000 447 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(21), C5(11), C6(10), C7(2), ICAM1(1), IL1A(2), IL8(1), ITGA4(9), ITGAL(11), ITGB1(6), ITGB2(5), SELP(6), SELPLG(6), TNF(1), VCAM1(8) 8155883 100 51 98 35 35 24 3 29 9 0 0.260 1.000 1.000 448 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(18), COL4A2(10), COL4A3(8), COL4A4(10), COL4A5(9), COL4A6(6), P4HB(2), SLC23A1(4), SLC23A2(9), SLC2A1(6), SLC2A3(5) 8239432 87 51 87 43 32 29 2 19 5 0 0.695 1.000 1.000 449 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(2), EPHA4(14), EPHB1(18), FYN(8), ITGA1(7), ITGB1(6), L1CAM(12), LYN(4), RAP1B(5), SELP(6) 5190737 82 50 80 33 32 15 8 21 5 1 0.487 1.000 1.000 450 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(3), B3GNT2(2), B3GNT7(3), B4GALT1(2), B4GALT2(5), B4GALT3(2), B4GALT4(4), CHST1(13), CHST2(10), CHST4(4), CHST6(6), FUT8(3), ST3GAL1(4), ST3GAL2(4), ST3GAL3(1), ST3GAL4(4) 4083927 70 50 68 28 39 16 1 11 3 0 0.429 1.000 1.000 451 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA2(4), ACADL(2), ACADM(4), ACADS(3), ACADSB(5), ACAT1(3), ACAT2(3), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH6A1(4), ALDH9A1(3), AOX1(7), BCAT1(3), BCKDHA(5), BCKDHB(1), EHHADH(6), HADHA(4), HADHB(4), HIBADH(3), IVD(4), MCCC1(3), MCCC2(3), MCEE(2), MUT(3), OXCT1(6), PCCA(8), PCCB(4), SDS(2) 11820864 132 50 128 51 29 52 2 27 21 1 0.575 1.000 1.000 452 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(6), AGT(3), AGTR1(1), AGTR2(2), COL4A1(18), COL4A2(10), COL4A3(8), COL4A4(10), COL4A5(9), COL4A6(6), REN(2) 8301669 75 49 75 31 25 24 3 20 3 0 0.401 1.000 1.000 453 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(4), ABAT(4), ADSL(3), ADSS(4), AGXT(1), AGXT2(7), ASL(5), ASNS(3), ASPA(1), CAD(12), CRAT(1), DARS(2), DDO(4), GAD1(6), GAD2(7), GOT1(2), GOT2(2), GPT(1), GPT2(2), NARS(4), PC(7) 8542230 82 49 80 43 34 26 0 19 3 0 0.902 1.000 1.000 454 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(6), AGT(3), AGTR2(2), EDN1(2), EDNRA(3), EDNRB(20), EGF(8), EGFR(11), FOS(1), JUN(3), MYC(3), NFKB1(7), PLCG1(16), PRKCA(3), RELA(3) 6755694 91 49 86 31 32 20 5 26 8 0 0.313 1.000 1.000 455 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(4), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), CYP2C19(7), DHRS1(1), DHRS2(1), DHRS3(2), DHRS7(3), DHRSX(5), EHHADH(6), ESCO1(4), ESCO2(4), HADHA(4), MYST3(20), MYST4(15), NAT6(2), PNPLA3(1), SH3GLB1(1), YOD1(2) 10139122 110 49 109 31 30 37 2 26 15 0 0.0805 1.000 1.000 456 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA2(4), ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH6(5), ADH7(1), ADHFE1(8), AKR1C4(5), AKR1D1(2), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), BAAT(1), CEL(7), CYP27A1(4), CYP7A1(4), HADHB(4), SOAT2(2), SRD5A1(3), SRD5A2(3) 7624006 99 48 98 36 25 33 2 25 14 0 0.355 1.000 1.000 457 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(9), CHAT(4), COMT(4), DBH(5), DDC(5), GAD1(6), GAD2(7), HDC(7), MAOA(1), PAH(4), PNMT(8), SLC18A3(7), TH(2), TPH1(3) 4707288 73 48 72 37 30 17 2 20 4 0 0.827 1.000 1.000 458 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(2), CREB1(3), CREBBP(26), EP300(19), NCOA3(11), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), RARA(2), RXRA(3) 6778303 88 48 87 33 30 30 1 13 14 0 0.357 1.000 1.000 459 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(6), CD2(2), CD33(7), CD5(4), CD7(3), IFNA1(1), IFNB1(2), IFNG(2), IL10(2), IL12A(2), IL12B(1), IL13(1), IL3(1), IL4(1), ITGAX(8), TLR2(1), TLR4(18), TLR7(5), TLR9(13) 6104533 80 48 75 41 23 17 5 28 7 0 0.941 1.000 1.000 460 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(5), CS(2), DLAT(3), DLD(3), DLST(4), FH(2), IDH2(1), IDH3A(1), IDH3B(2), IDH3G(3), MDH1(3), OGDH(7), PC(7), PDHA1(1), PDHA2(4), PDHB(3), PDHX(2), PDK1(2), PDK3(4), PDK4(2), PDP2(4), SDHA(6), SDHB(4), SDHC(1), SUCLA2(4), SUCLG1(2), SUCLG2(2) 9315063 84 48 82 42 28 25 2 16 13 0 0.933 1.000 1.000 461 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(1), BIRC2(3), BIRC3(3), CASP3(2), CASP8(8), JUN(3), MAP2K4(7), MAP3K3(4), MAP3K7(8), NFKB1(7), NFKB2(2), NFKBIA(1), NFKBIB(5), NFKBIL1(2), NFKBIL2(7), NR2C2(2), RALBP1(5), RIPK1(1), TNF(1), TNFAIP3(5), TNFRSF1A(3), TNFRSF1B(1), TRADD(2), TRAF2(2) 8913854 85 48 85 32 29 19 6 19 12 0 0.469 1.000 1.000 462 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(2), ALOX15(3), ALOX5(6), CYP1A2(4), CYP2C18(3), CYP2C19(7), CYP2C8(1), CYP2E1(4), CYP2J2(4), CYP3A4(2), CYP3A43(4), CYP3A7(4), HSD3B7(4), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(1), PLA2G2D(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), RDH11(1), RDH12(1), RDH13(3) 7853020 82 47 82 26 24 26 3 23 6 0 0.209 1.000 1.000 463 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(4), CARS(4), DARS(2), EPRS(7), FARS2(6), GARS(1), HARS(5), IARS(9), KARS(5), LARS(4), LARS2(7), MARS(4), MARS2(1), NARS(4), QARS(3), RARS(4), SARS(4), TARS(6), WARS(3), WARS2(7), YARS(3) 10538377 93 46 92 29 29 30 3 22 9 0 0.237 1.000 1.000 464 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(16), GNAS(20), GNGT1(3), PPP2CA(3), PRKAA1(4), PRKAA2(5), PRKAB1(2), PRKAB2(2), PRKACB(2), PRKACG(5), PRKAG1(3), PRKAG2(3), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7) 5032008 83 46 82 34 32 24 1 17 9 0 0.694 1.000 1.000 465 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(6), DCXR(1), GUSB(8), RPE(4), UGDH(5), UGP2(3), UGT1A1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A5(8), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2A1(3), UGT2A3(3), UGT2B10(8), UGT2B11(2), UGT2B15(2), UGT2B28(5), UGT2B4(3), UGT2B7(3), XYLB(5) 8903723 80 46 80 24 18 29 3 23 7 0 0.147 1.000 1.000 466 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(4), CARM1(2), CBS(5), CTH(2), GGT1(4), HEMK1(1), LCMT1(1), LCMT2(7), MARS(4), MARS2(1), MAT1A(2), MAT2B(2), METTL6(2), PAPSS1(4), PAPSS2(4), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(4), PRMT8(3), SCLY(1), SEPHS1(4), SEPHS2(2), WBSCR22(4) 8183586 72 46 71 40 24 19 4 13 12 0 0.928 1.000 1.000 467 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(7), ELK1(3), FOS(1), GRB2(4), IL6R(1), IL6ST(4), JAK1(6), JAK2(10), JAK3(9), JUN(3), MAP2K1(5), MAPK3(1), PTPN11(5), RAF1(7), SHC1(3), SOS1(6), SRF(1), STAT3(6) 7830204 82 46 79 34 19 28 1 31 3 0 0.722 1.000 1.000 468 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(3), ASNS(3), CA14(3), CA2(1), CA3(3), CA4(3), CA5B(1), CA6(3), CA7(3), CA8(3), CA9(4), CPS1(18), CTH(2), GLS(8), GLS2(6), GLUD1(3), GLUL(5), HAL(1) 6241441 73 46 73 33 16 28 3 19 7 0 0.833 1.000 1.000 469 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(13), APOA1(5), APOA4(5), APOC2(1), APOE(1), CETP(3), CYP7A1(4), DGAT1(1), HMGCR(6), LCAT(4), LDLR(7), LIPC(2), LPL(4), LRP1(25), SCARB1(4), SOAT1(6) 8995945 91 46 88 40 40 18 7 19 7 0 0.705 1.000 1.000 470 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(4), GPLD1(8), PGAP1(8), PIGA(2), PIGB(5), PIGC(3), PIGG(8), PIGK(3), PIGL(2), PIGM(5), PIGN(5), PIGO(4), PIGP(1), PIGQ(2), PIGS(3), PIGT(2), PIGU(1), PIGV(4), PIGW(1), PIGX(2), PIGZ(2) 7810694 75 45 73 32 22 24 2 18 8 1 0.654 1.000 1.000 471 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(16), ADRB2(7), GNAS(20), PLCE1(11), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7) 4845460 76 45 75 40 31 24 0 14 7 0 0.932 1.000 1.000 472 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CREBBP(26), EP300(19), HDAC3(4), IKBKB(7), NFKB1(7), NFKBIA(1), RELA(3), RIPK1(1), TNF(1), TNFRSF1A(3), TNFRSF1B(1), TRADD(2), TRAF6(5) 7319376 80 45 79 30 27 23 2 14 14 0 0.476 1.000 1.000 473 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 CASP2(3), CRADD(1), IKBKB(7), JUN(3), LTA(3), MAP2K3(7), MAP2K4(7), MAP2K6(1), MAP3K1(9), MAP3K14(3), MAP4K2(4), MAPK14(1), MAPK8(5), NFKB1(7), NFKBIA(1), RELA(3), RIPK1(1), TANK(3), TNF(1), TNFRSF1A(3), TRADD(2), TRAF2(2) 7876599 77 45 75 29 23 21 5 11 17 0 0.497 1.000 1.000 474 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(7), CCNB1(3), CCND1(1), CCND2(3), CCND3(2), CCNE1(3), CCNH(2), CDC25A(3), CDK2(3), CDK6(4), CDKN1A(1), CDKN2A(6), CDKN2D(3), E2F1(2), RB1(6), RBL1(7), TFDP1(3) 5270869 59 44 57 23 14 22 2 15 6 0 0.584 1.000 1.000 475 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(3), ARSB(2), ARSD(4), ARSE(4), ASAH1(2), GAL3ST1(6), GALC(5), GBA(6), GLB1(2), LCT(15), NEU1(1), NEU2(3), NEU3(4), NEU4(1), PPAP2A(1), PPAP2C(4), SMPD1(5), SMPD2(1), SPTLC1(1), SPTLC2(3), UGCG(3) 7922149 76 44 75 31 33 27 3 7 6 0 0.436 1.000 1.000 476 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(2), GALNS(1), GLB1(2), GNS(3), GUSB(8), HEXA(2), HEXB(2), HGSNAT(3), HPSE(6), HPSE2(2), HYAL1(4), HYAL2(4), IDS(3), IDUA(2), LCT(15), NAGLU(3), SPAM1(8) 6697252 70 44 69 28 21 28 3 13 5 0 0.500 1.000 1.000 477 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(9), AMT(3), ATIC(6), FTCD(2), GART(8), MTFMT(1), MTHFD1(3), MTHFD1L(6), MTHFD2(1), MTHFR(6), MTHFS(1), MTR(12), SHMT1(1), SHMT2(5), TYMS(1) 6208573 65 44 63 26 19 16 4 13 13 0 0.531 1.000 1.000 478 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(12), POLR1B(4), POLR1C(2), POLR1D(1), POLR2A(15), POLR2B(9), POLR2C(2), POLR2E(2), POLR2F(1), POLR2G(1), POLR2I(1), POLR2K(1), POLR3A(15), POLR3B(7), POLR3G(2), POLR3K(1) 7710349 76 44 75 24 28 23 1 20 4 0 0.238 1.000 1.000 479 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(16), CREM(3), FHL5(1), FSHB(1), FSHR(18), GNAS(20), XPO1(5) 3146848 64 43 61 25 22 15 2 21 4 0 0.842 1.000 1.000 480 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(1), CSF1R(7), DDX20(4), E2F1(2), E2F4(1), ETS1(5), ETS2(3), ETV3(1), FOS(1), HDAC2(2), HDAC5(6), JUN(3), NCOR2(21), RBL1(7), RBL2(4), SIN3A(8), SIN3B(10) 8479106 86 43 86 33 29 21 4 23 9 0 0.537 1.000 1.000 481 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(6), F2(5), F2R(2), F3(1), F5(13), F7(9), FGA(7), FGB(2), FGG(2), PROC(2), PROS1(8), SERPINC1(4), TFPI(3) 5388988 64 43 64 24 19 18 4 20 3 0 0.530 1.000 1.000 482 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(3), ALDOC(3), FBP1(2), FBP2(4), G6PD(2), GPI(5), H6PD(4), PFKL(4), PFKM(3), PFKP(8), PGD(6), PGLS(2), PGM1(2), PGM3(10), PRPS1(2), PRPS1L1(2), PRPS2(2), RBKS(1), RPE(4), RPIA(1), TALDO1(4), TKT(3), TKTL1(8), TKTL2(7) 7958475 92 43 92 32 29 32 5 20 6 0 0.162 1.000 1.000 483 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(7), BST1(2), C9orf95(1), CD38(3), ENPP1(5), ENPP3(4), NADK(6), NADSYN1(4), NMNAT1(1), NMNAT2(1), NMNAT3(1), NNMT(1), NNT(11), NT5C(1), NT5C1A(4), NT5C1B(5), NT5C2(7), NT5C3(1), NUDT12(3) 7052766 68 43 66 38 22 23 3 10 9 1 0.939 1.000 1.000 484 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(2), CSF1R(7), EGF(8), EGFR(11), GRB2(4), MET(7), PDGFRA(11), PRKCA(3), SH3GLB1(1), SH3GLB2(5), SH3KBP1(10), SRC(2) 6383057 71 42 69 39 26 19 2 13 11 0 0.942 1.000 1.000 485 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(16), ADRB2(7), CFTR(8), GNAS(20), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7) 4283034 73 42 72 34 30 21 0 15 7 0 0.859 1.000 1.000 486 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(8), ACO2(5), CS(2), DLD(3), DLST(4), FH(2), IDH1(1), IDH2(1), IDH3A(1), IDH3B(2), IDH3G(3), MDH1(3), PC(7), PCK1(6), SDHA(6), SDHB(4), SUCLA2(4), SUCLG1(2), SUCLG2(2) 6765651 66 42 63 28 32 15 1 10 8 0 0.561 1.000 1.000 487 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(8), EGFR(11), MAP2K1(5), MAP3K1(9), MAPK14(1), NCOR2(21), RARA(2), RXRA(3), THRA(4), THRB(7) 5644405 71 42 68 34 30 18 1 14 8 0 0.826 1.000 1.000 488 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(4), AMD1(3), BHMT(4), CBS(5), CTH(2), DNMT1(12), DNMT3A(5), DNMT3B(9), MARS(4), MARS2(1), MAT1A(2), MAT2B(2), MTAP(1), MTFMT(1), MTR(12), SRM(1), TAT(4) 6799749 72 42 70 40 23 26 2 13 8 0 0.926 1.000 1.000 489 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(5), FUCA1(1), FUCA2(1), GLB1(2), HEXA(2), HEXB(2), LCT(15), MAN2B1(10), MAN2B2(12), MAN2C1(7), MANBA(5), NEU1(1), NEU2(3), NEU3(4), NEU4(1) 6663517 71 42 70 27 29 20 3 11 8 0 0.460 1.000 1.000 490 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(4), B4GALNT1(3), GLB1(2), HEXA(2), HEXB(2), LCT(15), SLC33A1(4), ST3GAL1(4), ST3GAL2(4), ST3GAL5(2), ST6GALNAC3(5), ST6GALNAC5(1), ST6GALNAC6(2), ST8SIA1(4), ST8SIA5(4) 5403872 58 42 58 34 25 15 1 13 4 0 0.955 1.000 1.000 491 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(2), GALNT10(5), GALNT2(4), GALNT3(2), GALNT4(2), GALNT6(2), GALNT8(5), GALNT9(2), ST3GAL1(4), ST3GAL2(4), ST3GAL4(4), WBSCR17(22) 4742550 58 42 56 19 26 11 5 12 4 0 0.325 1.000 1.000 492 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(4), ARFGAP1(2), ARFGAP3(4), ARFGEF2(19), CLTA(2), CLTB(1), COPA(6), GBF1(14), GPLD1(8), KDELR1(2), KDELR2(2) 5335434 64 41 64 23 22 29 1 10 2 0 0.244 1.000 1.000 493 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(5), ARHGDIB(1), BIRC2(3), BIRC3(3), CASP1(2), CASP10(5), CASP2(3), CASP3(2), CASP4(4), CASP6(1), CASP7(2), CASP8(8), CASP9(2), DFFA(4), DFFB(3), GZMB(2), LMNA(3), LMNB1(1), LMNB2(4), PRF1(1) 6328543 59 41 58 22 18 15 5 15 6 0 0.582 1.000 1.000 494 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(1), C1R(3), C1S(5), C2(2), C3(21), C5(11), C6(10), C7(2), C8A(5), C9(6), MASP1(3), MASP2(4), MBL2(1) 7007514 74 41 72 26 24 19 4 16 10 1 0.519 1.000 1.000 495 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(3), BCAT2(5), IARS(9), IARS2(7), ILVBL(3), LARS(4), LARS2(7), PDHA1(1), PDHA2(4), PDHB(3), VARS(10), VARS2(9) 6103991 65 41 65 25 21 18 2 16 8 0 0.679 1.000 1.000 496 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(3), ALDOC(3), FBP1(2), FBP2(4), GOT1(2), GOT2(2), GPT(1), GPT2(2), MDH1(3), ME1(1), ME3(4), PGK1(4), PGK2(2), PKLR(5), PKM2(5), RPE(4), RPIA(1), TKT(3), TKTL1(8), TKTL2(7), TPI1(1) 6615512 67 41 67 34 23 21 4 16 3 0 0.856 1.000 1.000 497 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(4), IL22RA1(1), IL22RA2(1), JAK1(6), JAK2(10), JAK3(9), SOCS3(3), STAT1(7), STAT3(6), STAT5A(4), STAT5B(6), TYK2(4) 6019507 61 41 60 23 16 18 2 20 5 0 0.560 1.000 1.000 498 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(9), AMT(3), ATIC(6), GART(8), MTHFD1(3), MTHFD1L(6), MTHFD2(1), MTHFR(6), MTHFS(1), MTR(12), SHMT1(1), SHMT2(5), TYMS(1) 5872118 62 41 60 22 18 16 4 12 12 0 0.323 1.000 1.000 499 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(5), AKR1D1(2), ARSB(2), ARSD(4), ARSE(4), CYP11B1(7), CYP11B2(4), HSD11B1(2), HSD11B2(2), HSD17B2(2), HSD17B3(1), HSD3B1(1), HSD3B2(3), SRD5A1(3), SRD5A2(3), STS(4), SULT1E1(2), SULT2A1(3), UGT1A1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A5(8), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2B15(2), UGT2B4(3) 8941815 78 40 78 29 22 32 2 13 9 0 0.320 1.000 1.000 500 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(5), GABRA1(12), GABRA2(5), GABRA3(7), GABRA4(7), GABRA5(5), GABRA6(8), GPHN(9), NSF(1), SRC(2), UBQLN1(4) 3926090 65 40 65 25 12 14 9 27 3 0 0.673 1.000 1.000 501 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(6), G6PD(2), GCLC(1), GCLM(2), GGT1(4), GPX1(1), GPX2(1), GPX3(1), GPX5(1), GPX6(3), GPX7(3), GSR(4), GSS(3), GSTA1(2), GSTA2(1), GSTA4(2), GSTA5(2), GSTK1(1), GSTM2(1), GSTM3(2), GSTM4(2), GSTM5(1), GSTO2(3), GSTZ1(3), IDH1(1), IDH2(1), MGST1(2), MGST3(2), OPLAH(5), TXNDC12(1) 7178462 64 40 64 29 22 18 1 17 6 0 0.707 1.000 1.000 502 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 ABO(1), B3GNT1(3), B3GNT2(2), B3GNT3(5), B3GNT4(4), B3GNT5(3), B4GALT1(2), B4GALT2(5), B4GALT3(2), B4GALT4(4), FUT1(2), FUT3(1), FUT4(1), FUT5(2), FUT6(2), FUT7(2), FUT9(5), GCNT2(1), ST3GAL6(3), ST8SIA1(4) 5278238 54 40 53 22 21 16 2 12 3 0 0.539 1.000 1.000 503 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(3), ALDOC(3), FBP1(2), FBP2(4), G6PD(2), GPI(5), H6PD(4), PFKM(3), PFKP(8), PGD(6), PGLS(2), PGM1(2), PGM3(10), PRPS1(2), PRPS1L1(2), PRPS2(2), RBKS(1), RPE(4), RPIA(1), TAL1(1), TALDO1(4), TKT(3) 6701187 74 40 74 27 24 24 4 17 5 0 0.237 1.000 1.000 504 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(5), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(2), ATP6V0D1(6), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(6), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(5), FDXR(3), SHMT1(1) 5259322 65 40 63 23 17 21 3 15 9 0 0.410 1.000 1.000 505 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(4), BLVRA(3), CP(9), CPOX(2), EPRS(7), FECH(6), GUSB(8), HCCS(1), HMBS(2), HMOX1(5), HMOX2(1), PPOX(2), UGT1A1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A5(8), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2B15(2), UGT2B4(3), UROD(1), UROS(3) 8975452 78 40 78 32 20 29 1 19 9 0 0.665 1.000 1.000 506 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(5), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(2), ATP6V0D1(6), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(6), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(5), SHMT1(1) 4945363 62 39 60 22 15 21 3 15 8 0 0.437 1.000 1.000 507 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(3), ALDOC(3), FBP1(2), FBP2(4), GOT1(2), GOT2(2), GPT(1), GPT2(2), MDH1(3), ME1(1), ME2(4), ME3(4), PGK1(4), PKLR(5), PKM2(5), RPE(4), RPIA(1), TKT(3), TPI1(1) 5914458 54 39 54 27 18 18 3 12 3 0 0.805 1.000 1.000 508 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(8), EGFR(11), ERBB3(29), NRG1(11) 3381148 59 39 53 22 23 15 2 17 2 0 0.560 1.000 1.000 509 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(5), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(2), ATP6V0D1(6), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(6), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(5), SHMT1(1) 4945363 62 39 60 22 15 21 3 15 8 0 0.437 1.000 1.000 510 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(9), ABCC2(11), ABCG2(3), BCHE(11), CES1(8), CES2(5), CYP3A4(2), UGT1A1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A5(8), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2) 7512643 68 39 68 29 18 22 2 18 8 0 0.704 1.000 1.000 511 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(2), ALG5(2), B4GALT1(2), B4GALT2(5), B4GALT3(2), B4GALT5(5), DPAGT1(1), DPM1(1), FUT8(3), MAN1A1(2), MAN1B1(5), MGAT1(2), MGAT2(2), MGAT3(5), MGAT4A(2), MGAT4B(2), MGAT5(8), RPN1(2), RPN2(3) 6520781 56 39 55 32 21 13 5 10 7 0 0.954 1.000 1.000 512 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(5), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(2), ATP6V0D1(6), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(6), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(5), SHMT1(1) 4945363 62 39 60 22 15 21 3 15 8 0 0.437 1.000 1.000 513 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(1), C1R(3), C1S(5), C2(2), C3(21), C5(11), C6(10), C7(2), C8A(5), C9(6) 5756517 66 38 64 24 21 16 4 16 8 1 0.630 1.000 1.000 514 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(2), POLD1(10), POLD2(1), POLE(17), POLG(5), POLL(2), POLQ(22) 5484674 59 38 59 31 18 13 3 15 10 0 0.947 1.000 1.000 515 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPL13(1), MRPS7(1), RPL10A(1), RPL10L(9), RPL12(1), RPL13A(2), RPL14(1), RPL18(1), RPL19(2), RPL22L1(1), RPL23A(1), RPL24(1), RPL26(1), RPL28(1), RPL3(2), RPL31(1), RPL34(2), RPL36A(1), RPL38(1), RPL3L(2), RPL6(1), RPL7(1), RPL8(2), RPL9(3), RPS10(1), RPS11(1), RPS13(2), RPS23(1), RPS24(1), RPS27(1), RPS3(1), RPS3A(2), RPS4Y1(1), RPS5(3), RPS6(1), RPS9(1), RPSA(6) 7417354 62 38 62 27 19 22 1 12 8 0 0.858 1.000 1.000 516 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(6), ACE2(6), AGT(3), AGTR1(1), AGTR2(2), ANPEP(6), CPA3(1), CTSA(1), CTSG(3), ENPEP(9), LNPEP(8), MAS1(1), MME(5), NLN(6), REN(2), THOP1(4) 6936406 64 38 64 27 24 22 3 13 2 0 0.525 1.000 1.000 517 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(5), CLOCK(3), CRY1(3), CRY2(4), CSNK1D(2), CSNK1E(7), NPAS2(9), NR1D1(4), PER1(5), PER2(9), PER3(8) 5582542 59 38 59 21 16 13 3 17 10 0 0.525 1.000 1.000 518 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(3), CAT(4), EPX(6), LPO(7), MPO(6), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(1), SHMT1(1), SHMT2(5), TPO(15) 3855470 52 38 52 18 17 10 4 12 9 0 0.423 1.000 1.000 519 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(4), BHMT(4), CBS(5), CTH(2), DNMT1(12), DNMT3A(5), DNMT3B(9), MARS(4), MARS2(1), MAT1A(2), MAT2B(2), MTR(12) 5701888 62 38 60 35 22 20 2 10 8 0 0.921 1.000 1.000 520 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(4), ICAM1(1), ITGA4(9), ITGAL(11), ITGAM(6), ITGB1(6), ITGB2(5), SELE(4), SELL(4), SELP(6) 5240905 56 38 55 31 22 10 1 15 8 0 0.937 1.000 1.000 521 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR1(2), CCR2(5), CCR3(6), CCR5(3), CCR7(2), CD4(5), CXCR4(1), IFNG(2), IFNGR1(5), IFNGR2(1), IL12A(2), IL12B(1), IL12RB1(4), IL12RB2(8), IL18R1(2), IL4(1), IL4R(1), TGFB1(3), TGFB2(6), TGFB3(5) 6573665 65 38 65 30 17 17 2 23 6 0 0.833 1.000 1.000 522 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(7), ESR2(8), ITPKA(1), PDE1A(6), PDE1B(3), PLCB1(13), PLCB2(4), PRL(1), TRH(3), VIP(3) 3641575 49 38 48 22 16 12 4 14 3 0 0.764 1.000 1.000 523 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(7), DNMT1(12), MTNR1A(4), MTNR1B(6), PTAFR(5), PTGDR(6), PTGER2(4), PTGER4(4), PTGFR(3), TBXA2R(8) 3644520 59 38 59 32 24 17 3 13 2 0 0.808 1.000 1.000 524 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(6), GBA3(1), LPO(7), MPO(6), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(1), TPO(15), TYR(6) 3150845 46 37 46 21 13 11 4 14 4 0 0.806 1.000 1.000 525 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(3), GNAS(20), GNGT1(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKCA(3) 3149049 51 36 50 17 24 11 2 9 5 0 0.423 1.000 1.000 526 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(6), G6PD(2), GCLC(1), GCLM(2), GGT1(4), GPX1(1), GPX2(1), GPX3(1), GPX5(1), GSS(3), GSTA1(2), GSTA2(1), GSTA4(2), GSTM2(1), GSTM3(2), GSTM4(2), GSTM5(1), GSTO2(3), GSTZ1(3), IDH1(1), IDH2(1), MGST1(2), MGST3(2), PGD(6) 5906218 51 36 51 18 18 14 0 14 5 0 0.335 1.000 1.000 527 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP2(2), ACP5(1), ACP6(2), ACPP(2), ACPT(4), ALPI(6), ALPL(4), ALPP(7), ALPPL2(6), CYP3A4(2), CYP3A43(4), CYP3A7(4), DHRS1(1), DHRS2(1), DHRS3(2), DHRS7(3), DHRSX(5), PON1(2), PON2(3), PON3(1) 5910298 62 36 61 28 25 18 1 11 7 0 0.632 1.000 1.000 528 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(2), ALDH18A1(6), ARG1(2), ASL(5), CKB(1), CKMT1A(3), CKMT1B(1), CKMT2(6), CPS1(18), GATM(3), GLUD1(3), NAGS(1), ODC1(3), OTC(2), PYCR1(3), SMS(3) 5735231 62 36 62 21 23 17 3 17 2 0 0.291 1.000 1.000 529 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(3), CYP51A1(6), DHCR24(2), DHCR7(3), EBP(1), FDPS(6), GGCX(2), GGPS1(1), HMGCR(6), HSD17B7(2), LSS(4), MVD(2), MVK(8), NQO1(2), NSDHL(3), SC4MOL(4), SC5DL(4), SQLE(4), TM7SF2(1) 6316156 64 35 62 24 19 16 3 17 9 0 0.613 1.000 1.000 530 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(4), HK1(11), HK2(8), HK3(5), IMPA1(3), IMPA2(1), ISYNA1(2), PGM1(2), PGM3(10), TGDS(3) 3826449 49 35 49 20 15 17 2 12 3 0 0.465 1.000 1.000 531 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(6), GBA(6), GBA3(1), LPO(7), MPO(6), PRDX6(1), TPO(15) 2737617 42 35 42 17 16 11 2 10 3 0 0.608 1.000 1.000 532 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(7), FOS(1), GRB2(4), IL3(1), IL3RA(5), JAK2(10), MAP2K1(5), MAPK3(1), PTPN6(3), RAF1(7), SHC1(3), SOS1(6), STAT5A(4), STAT5B(6) 5806936 63 35 60 24 20 22 0 18 3 0 0.552 1.000 1.000 533 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 CTSD(4), ESR1(7), GREB1(20), MTA1(6), MTA3(2), PDZK1(2), TUBA8(4) 3576892 45 35 45 21 18 15 3 5 4 0 0.574 1.000 1.000 534 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(5), FUCA1(1), FUCA2(1), GLB1(2), HEXA(2), HEXB(2), LCT(15), MAN2C1(7), MANBA(5), NEU1(1), NEU2(3), NEU3(4), NEU4(1) 5403449 49 35 49 22 17 15 2 8 7 0 0.783 1.000 1.000 535 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 DUSP1(2), IKBKAP(6), IKBKB(7), LTA(3), MAP3K1(9), MAP3K14(3), NFKB1(7), NFKBIA(1), RELA(3), RIPK1(1), TANK(3), TNFAIP3(5), TNFRSF1B(1), TRAF1(3), TRAF2(2), TRAF3(3) 7365885 59 35 57 25 22 13 2 10 12 0 0.747 1.000 1.000 536 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(2), GALNS(1), GLB1(2), GNS(3), GUSB(8), HEXA(2), HEXB(2), IDS(3), IDUA(2), LCT(15), NAGLU(3) 4691627 43 34 43 23 13 17 0 9 4 0 0.843 1.000 1.000 537 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(2), ACTR2(2), ACTR3(2), ARPC1A(3), ARPC2(1), ARPC4(2), NCK1(6), NCKAP1(8), NTRK1(6), PIR(1), PSMA7(4), WASF1(3), WASF2(6), WASF3(6), WASL(1) 5011433 53 33 52 28 24 15 2 6 6 0 0.858 1.000 1.000 538 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 DUSP1(2), IKBKAP(6), IKBKB(7), MAP3K1(9), MAP3K14(3), NFKB1(7), NFKBIA(1), RELA(3), TNFAIP3(5), TRAF3(3), TRAF6(5) 5950050 51 33 49 17 19 11 2 9 10 0 0.483 1.000 1.000 539 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 APEX1(2), CREBBP(26), DFFA(4), DFFB(3), GZMA(1), GZMB(2), HMGB2(2), PRF1(1), SET(3) 3465016 44 33 44 17 13 15 2 8 6 0 0.477 1.000 1.000 540 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3E(2), CD4(5), FYN(8), HLA-DRA(6), LCK(3), PTPRC(15), ZAP70(10) 2967631 49 33 47 23 13 18 1 15 2 0 0.834 1.000 1.000 541 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP2(2), ACP5(1), ACP6(2), ACPP(2), ACPT(4), ENPP1(5), ENPP3(4), FLAD1(3), LHPP(3), MTMR1(4), MTMR2(3), MTMR6(5), PHPT1(2), RFK(1), TYR(6) 4937950 47 32 47 17 10 17 3 12 5 0 0.432 1.000 1.000 542 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX1(4), ACOX3(8), ELOVL2(4), ELOVL5(2), ELOVL6(1), FADS1(2), FADS2(4), FASN(14), HADHA(4), HSD17B12(2), SCD(1) 4650230 46 32 42 22 22 8 2 7 7 0 0.734 1.000 1.000 543 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(3), CD3E(2), ETV5(3), IFNG(2), IL12A(2), IL12B(1), IL12RB1(4), IL12RB2(8), IL18(1), IL18R1(2), JAK2(10), JUN(3), MAP2K6(1), MAPK14(1), MAPK8(5), STAT4(3), TYK2(4) 6120380 55 32 55 23 8 22 4 15 6 0 0.740 1.000 1.000 544 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(6), CD44(4), CSF1(1), FCGR3A(3), IL1B(2), IL6R(1), SELL(4), SPN(3), TGFB1(3), TGFB2(6), TNF(1), TNFRSF1A(3), TNFRSF1B(1), TNFRSF8(2), TNFSF8(3) 4313736 43 32 43 27 15 11 0 11 6 0 0.951 1.000 1.000 545 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(1), IL6R(1), JAK1(6), JAK2(10), JAK3(9), PIAS3(2), PTPRU(16), REG1A(3), SRC(2), STAT3(6) 4997029 56 32 55 26 17 19 0 17 3 0 0.805 1.000 1.000 546 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(3), HMOX1(5), IL10(2), IL10RA(4), IL10RB(2), IL1A(2), JAK1(6), STAT1(7), STAT3(6), STAT5A(4), TNF(1) 4009679 42 31 42 16 10 11 1 16 4 0 0.613 1.000 1.000 547 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD3E(2), CD8A(4), ICAM1(1), ITGAL(11), ITGB2(5), PTPRC(15), THY1(1) 3533188 41 31 39 19 11 12 2 13 3 0 0.783 1.000 1.000 548 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(4), FUT1(2), FUT9(5), GBGT1(1), HEXA(2), HEXB(2), NAGA(4), ST3GAL1(4), ST3GAL2(4), ST3GAL4(4), ST8SIA1(4) 3327035 36 30 36 15 18 5 0 11 2 0 0.646 1.000 1.000 549 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(3), B4GALT1(2), B4GALT2(5), B4GALT3(2), B4GALT5(5), FUT8(3), ST3GAL1(4), ST3GAL2(4), ST3GAL3(1), ST3GAL4(4) 2580773 33 30 32 11 16 9 1 6 1 0 0.399 1.000 1.000 550 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(2), PSMA2(1), PSMA3(2), PSMA4(4), PSMA6(4), PSMA7(4), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(3), PSMB5(1), PSMB6(1), PSMC3(6), RPN1(2), RPN2(3), UBE2A(1), UBE3A(5) 4248563 45 30 44 18 14 16 5 6 4 0 0.569 1.000 1.000 551 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK1(6), JAK2(10), JAK3(9), PIAS1(6), PIAS3(2), PTPRU(16), REG1A(3), SOAT1(6) 4497587 59 30 57 23 17 19 2 14 7 0 0.677 1.000 1.000 552 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD3E(2), CD4(5), ICAM1(1), ITGAL(11), ITGB2(5), PTPRC(15), THY1(1) 3706941 42 30 40 22 11 12 1 15 3 0 0.917 1.000 1.000 553 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(16), GNAS(20), GNGT1(3), PRKACA(3), PRKAR1A(3) 2169317 45 29 44 19 20 10 0 9 6 0 0.802 1.000 1.000 554 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(4), B3GALNT1(2), B3GALT5(1), FUT1(2), FUT9(5), GBGT1(1), HEXA(2), HEXB(2), NAGA(4), ST3GAL1(4), ST3GAL2(4), ST8SIA1(4) 3531535 35 29 35 17 17 4 1 11 2 0 0.816 1.000 1.000 555 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(3), GRB2(4), IL2RG(5), IL4(1), IL4R(1), IRS1(15), JAK1(6), JAK3(9), RPS6KB1(4), SHC1(3), STAT6(1) 4845760 52 29 50 22 16 17 0 9 10 0 0.776 1.000 1.000 556 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), EHHADH(6), HADHA(4), SDS(2) 3988987 48 29 47 20 13 15 0 11 9 0 0.642 1.000 1.000 557 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(4), ICAM1(1), ITGA4(9), ITGAL(11), ITGB1(6), ITGB2(5), SELE(4), SELL(4) 3986353 44 29 43 23 17 10 1 10 6 0 0.822 1.000 1.000 558 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(7), CD38(3), ENPP1(5), ENPP3(4), NADSYN1(4), NMNAT1(1), NMNAT2(1), NNMT(1), NNT(11), NT5C(1) 4764617 38 29 37 24 7 11 3 10 6 1 0.974 1.000 1.000 559 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(3), CD2(2), CD3E(2), CD4(5), IFNG(2), IL12A(2), IL12B(1), IL12RB1(4), IL12RB2(8), JAK2(10), STAT4(3), TYK2(4) 4821447 46 29 46 23 6 18 3 15 4 0 0.920 1.000 1.000 560 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(7), CCNA2(1), CCND1(1), CCNE1(3), CCNE2(2), CDK2(3), CDKN2A(6), E2F1(2), E2F2(3), E2F4(1), PRB1(2) 2933001 31 29 31 18 5 14 1 6 5 0 0.933 1.000 1.000 561 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(6), JAK2(10), JAK3(9), MAPK1(2), MAPK3(1), STAT3(6), TYK2(4) 3831596 38 29 37 17 9 15 0 12 2 0 0.761 1.000 1.000 562 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(8), ACO2(5), CS(2), GRHPR(2), HAO1(3), HAO2(3), HYI(2), MDH1(3), MTHFD1(3), MTHFD1L(6), MTHFD2(1) 4204956 38 28 37 18 14 15 1 4 4 0 0.707 1.000 1.000 563 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(2), DHRS1(1), DHRS2(1), DHRS3(2), DHRS7(3), DHRSX(5), HEMK1(1), LCMT1(1), LCMT2(7), METTL6(2), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(4), PRMT8(3), WBSCR22(4) 4932363 45 28 45 17 14 15 1 9 6 0 0.411 1.000 1.000 564 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(8), ACO2(5), AFMID(1), CS(2), GRHPR(2), HAO1(3), HAO2(3), HYI(2), MDH1(3), MTHFD1(3), MTHFD1L(6), MTHFD2(1) 4403536 39 28 38 18 15 15 1 4 4 0 0.665 1.000 1.000 565 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(1), CALM2(3), CAMK1(2), CAMK1G(3), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CAMK4(6), CAMKK1(5), CAMKK2(1), CREB1(3), SYT1(3) 3782577 39 27 39 18 12 17 2 6 2 0 0.638 1.000 1.000 566 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(5), DLL1(10), FURIN(4), NOTCH1(19), PSEN1(2) 3009188 40 27 40 24 17 6 4 8 5 0 0.902 1.000 1.000 567 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(4), CBS(5), CTH(2), GGT1(4), MARS(4), MARS2(1), MAT1A(2), MAT2B(2), PAPSS1(4), PAPSS2(4), SCLY(1), SEPHS1(4) 4058004 37 27 36 24 13 9 2 6 7 0 0.954 1.000 1.000 568 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD86(2), HLA-DRA(6), IFNG(2), IFNGR1(5), IFNGR2(1), IL12A(2), IL12B(1), IL12RB1(4), IL12RB2(8), IL18(1), IL18R1(2), IL2RA(2), IL4(1), IL4R(1) 4164756 38 27 38 19 11 11 2 11 3 0 0.804 1.000 1.000 569 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(9), CHAT(4), CHKA(1), PCYT1A(6), PDHA1(1), PDHA2(4), PEMT(1), SLC18A3(7) 2278795 33 26 33 22 12 8 0 10 3 0 0.965 1.000 1.000 570 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(5), CS(2), FH(2), IDH2(1), MDH1(3), OGDH(7), SDHA(6), SUCLA2(4) 3094516 30 26 29 12 11 8 2 4 5 0 0.587 1.000 1.000 571 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(4), ICAM1(1), ITGAL(11), ITGAM(6), ITGB2(5), SELE(4), SELL(4) 3412762 35 26 35 22 15 7 1 8 4 0 0.964 1.000 1.000 572 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3) 2620083 36 25 36 16 9 11 0 10 6 0 0.761 1.000 1.000 573 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3) 2620083 36 25 36 16 9 11 0 10 6 0 0.761 1.000 1.000 574 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(5), GAD1(6), HDC(7), PNMT(8), TH(2), TPH1(3) 1973649 31 25 30 17 14 7 2 6 2 0 0.858 1.000 1.000 575 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(3), ADSS(4), IMPDH1(5), MTHFD2(1), POLB(2), POLD1(10), POLG(5), PRPS2(2), RRM1(5), SRM(1) 4085683 38 25 38 16 10 15 2 8 3 0 0.628 1.000 1.000 576 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(6), CAPN1(2), CAPNS1(2), CAPNS2(2), CDK5(2), CDK5R1(1), CSNK1A1(3), CSNK1D(2), GSK3B(4), MAPT(4), PPP2CA(3) 3022973 31 25 30 20 11 10 0 6 4 0 0.952 1.000 1.000 577 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(1), IL13RA1(3), IL13RA2(6), IL4R(1), JAK1(6), JAK2(10), TYK2(4) 3442081 31 25 31 17 7 12 2 7 3 0 0.903 1.000 1.000 578 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(1), IL13RA1(3), IL13RA2(6), IL4R(1), JAK1(6), JAK2(10), TYK2(4) 3442081 31 25 31 17 7 12 2 7 3 0 0.903 1.000 1.000 579 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(6), AGT(3), AGTR1(1), AGTR2(2), BDKRB2(3), KNG1(8), NOS3(5), REN(2) 3220717 30 24 30 15 11 7 2 6 4 0 0.759 1.000 1.000 580 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(5), AKR1D1(2), CYP11A1(4), CYP11B1(7), CYP11B2(4), CYP17A1(3), CYP21A2(4), HSD11B1(2), HSD11B2(2), HSD3B1(1), HSD3B2(3) 3038945 37 24 37 15 13 12 2 9 1 0 0.527 1.000 1.000 581 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(9), EGF(8), EGFR(11), HGS(1), RAB5A(2), TF(6), TFRC(1) 4217844 38 24 38 23 11 9 1 13 3 1 0.968 1.000 1.000 582 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(5), AKR1D1(2), CYP11A1(4), CYP11B1(7), CYP11B2(4), CYP17A1(3), CYP21A2(4), HSD11B1(2), HSD11B2(2), HSD3B1(1), HSD3B2(3) 3038945 37 24 37 15 13 12 2 9 1 0 0.527 1.000 1.000 583 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(2), CAMK1G(3), HDAC9(6), MEF2B(4), MEF2C(3), MEF2D(6), MYOD1(4), YWHAH(3) 2537458 31 24 30 15 14 5 3 6 3 0 0.755 1.000 1.000 584 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(3), IARS(9), LARS(4), LARS2(7), PDHA1(1), PDHA2(4), PDHB(3) 3295346 31 24 31 15 4 10 1 9 7 0 0.922 1.000 1.000 585 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(2), APAF1(5), BCL2(2), CASP3(2), CASP9(2), DAXX(9), FAS(3), FASLG(2), IL1A(2), MAPKAPK2(1), MAPKAPK3(4), TNF(1) 3718456 35 23 35 19 14 8 0 10 3 0 0.888 1.000 1.000 586 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(2), ANKRD1(3), CYR61(1), DUSP14(2), EIF4E(2), EIF4EBP1(2), HBEGF(2), IFNG(2), IFRD1(3), IL18(1), IL1A(2), IL1R1(4), JUND(1), MYOG(1), NR4A3(4) 3499349 32 23 32 14 13 4 4 9 2 0 0.655 1.000 1.000 587 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP1(1), RANBP2(27), RANGAP1(5) 2768597 34 23 34 16 4 14 2 11 3 0 0.799 1.000 1.000 588 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(2), GNAQ(3), GNGT1(3), HTR2C(5), PLCB1(13), TUB(5) 2350041 31 23 30 12 9 7 0 9 6 0 0.666 1.000 1.000 589 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(2), IFNG(2), IL10(2), IL12A(2), IL12B(1), IL13(1), IL16(5), IL18(1), IL1A(2), IL3(1), IL4(1), IL8(1), LTA(3), TNF(1) 3263335 26 22 26 17 5 9 2 9 1 0 0.950 1.000 1.000 590 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(4), ST3GAL1(4), ST3GAL2(4), ST3GAL4(4), ST3GAL5(2), ST6GALNAC2(1), ST8SIA1(4) 1855029 23 22 23 11 12 4 0 7 0 0 0.677 1.000 1.000 591 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(2), DHRS1(1), DHRS2(1), DHRS3(2), DHRS7(3), DHRSX(5), HSD3B7(4), PON1(2), PON2(3), PON3(1), RDH11(1), RDH12(1), RDH13(3) 2954173 29 22 29 15 10 9 1 8 1 0 0.816 1.000 1.000 592 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), CDO1(1), CSAD(7), GAD1(6), GAD2(7), GGT1(4) 1885172 26 22 26 13 14 4 0 7 1 0 0.707 1.000 1.000 593 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(2), NRF1(5), TAX1BP3(2), UBE2A(1), UBE2D3(2), UBE2E3(3), UBE2G2(1), UBE2H(1), UBE2I(1), UBE2J1(1), UBE2J2(3), UBE2L3(1), UBE2L6(1), UBE2N(2), UBE3A(5) 3450536 31 22 31 16 14 9 0 4 4 0 0.770 1.000 1.000 594 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(2), CDK5R1(1), EGR1(4), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK3(1), NGFR(4), RAF1(7) 2674709 28 21 25 17 10 9 0 9 0 0 0.880 1.000 1.000 595 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(6), FARSA(1), FARSB(1), GOT1(2), GOT2(2), PAH(4), TAT(4), YARS(3), YARS2(3) 2858620 26 21 26 11 9 10 0 7 0 0 0.692 1.000 1.000 596 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), IFNGR1(5), IFNGR2(1), JAK1(6), JAK2(10), STAT1(7) 2699309 31 21 31 13 5 12 2 8 4 0 0.699 1.000 1.000 597 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(4), ADORA2A(1), ADORA2B(1), ADORA3(4), LTB4R(1), P2RY1(3), P2RY2(5), P2RY6(6) 1954313 25 21 25 10 15 3 0 5 2 0 0.429 1.000 1.000 598 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP2(3), MMP9(13), RECK(5), TIMP2(2), TIMP3(3) 2468477 26 21 26 14 13 6 0 3 4 0 0.706 1.000 1.000 599 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP2(2), ACP5(1), ACPP(2), ACPT(4), ENPP1(5), ENPP3(4), FLAD1(3), RFK(1), TYR(6) 3183031 28 21 28 11 5 9 2 8 4 0 0.574 1.000 1.000 600 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(6), EIF4E(2), FBL(4), GPT(1), LDHA(3), LDHB(4), LDHC(1), MAPK14(1), NCL(6) 2939806 28 21 28 11 6 8 0 10 4 0 0.739 1.000 1.000 601 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), BIRC3(3), CASP8(8), RIPK1(1), TNF(1), TNFRSF1A(3), TNFRSF1B(1), TRADD(2), TRAF2(2) 2731630 22 21 22 11 6 3 1 8 4 0 0.834 1.000 1.000 602 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(5), CLOCK(3), CRY1(3), CRY2(4), CSNK1E(7), PER1(5) 2776707 27 20 27 12 8 6 1 7 5 0 0.854 1.000 1.000 603 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(1), B3GALT1(3), B3GALT2(6), B3GALT5(1), B3GNT5(3), FUT1(2), FUT3(1), ST3GAL3(1), ST3GAL4(4) 2365956 22 20 22 12 12 4 0 4 2 0 0.846 1.000 1.000 604 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), EHHADH(6), HADH(3), HADHA(4), HSD17B4(4), NTAN1(3), SIRT1(4), SIRT2(1), SIRT5(3), SIRT7(3), VNN2(2) 3894410 34 20 33 12 8 7 4 5 10 0 0.496 1.000 1.000 605 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(6), BMPR1A(3), BMPR1B(4), BMPR2(11) 2056897 24 20 24 10 8 6 1 2 5 2 0.694 1.000 1.000 606 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(4), CYP11A1(4), CYP11B2(4), CYP17A1(3), HSD11B1(2), HSD11B2(2), HSD3B1(1), HSD3B2(3) 2272066 23 17 23 11 7 4 3 8 1 0 0.736 1.000 1.000 607 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(4), CS(2), MDH1(3), ME1(1), PC(7), PDHA1(1), SLC25A1(1), SLC25A11(1) 3040165 20 15 19 13 9 5 2 2 2 0 0.922 1.000 1.000 608 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(4), PLCD1(4), PRKCA(3), TGM2(5) 1632404 16 15 16 9 12 2 0 2 0 0 0.754 1.000 1.000 609 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(2), EPHX2(3), HSD3B7(4), RDH11(1), RDH12(1), RDH13(3) 1574645 14 14 14 9 4 6 0 4 0 0 0.868 1.000 1.000 610 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(2), ACTR2(2), ACTR3(2), ARPC1A(3), ARPC2(1), ARPC4(2), CDC42(1), WASF1(3), WASL(1) 2671379 17 13 17 20 5 6 1 3 2 0 1.000 1.000 1.000 611 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(1), COQ3(4), COQ6(2), COQ7(2), NDUFA13(3) 1309381 12 11 12 6 4 5 1 2 0 0 0.772 1.000 1.000 612 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(3), ALDH1A2(5), BCMO1(1), RDH5(2) 1281198 11 10 11 14 4 2 0 4 1 0 0.999 1.000 1.000 613 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(2), RAB11A(4), RAB27A(4), RAB4A(1), RAB5A(2), RAB6A(1) 1396343 14 9 14 12 5 6 0 2 1 0 0.947 1.000 1.000 614 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(1), FUT1(2), FUT3(1), FUT5(2), FUT6(2), ST3GAL3(1) 1666837 9 8 9 7 6 2 0 1 0 0 0.879 1.000 1.000 615 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(7) 665732 7 5 7 4 2 2 0 3 0 0 0.888 1.000 1.000 616 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 167479 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000