Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.111 0.243 0.57 56.0 -9999.0 0.0 56.0 KIRREL -0.018 0.109 -9999.0 0.0 -0.792 5.0 5.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.111 0.243 -9999.0 0.0 -0.572 56.0 56.0 PLCG1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP -0.131 0.203 -9999.0 0.0 -0.492 50.0 50.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.072 0.154 -9999.0 0.0 -0.518 12.0 12.0 FYN -0.105 0.194 -9999.0 0.0 -0.441 50.0 50.0 mol:Ca2+ -0.128 0.197 -9999.0 0.0 -0.478 50.0 50.0 mol:DAG -0.128 0.198 -9999.0 0.0 -0.481 50.0 50.0 NPHS2 -0.094 0.194 -9999.0 0.0 -0.495 51.0 51.0 mol:IP3 -0.128 0.198 -9999.0 0.0 -0.481 50.0 50.0 regulation of endocytosis -0.092 0.184 -9999.0 0.0 -0.411 50.0 50.0 Nephrin/NEPH1/podocin/Cholesterol -0.132 0.202 -9999.0 0.0 -0.491 50.0 50.0 establishment of cell polarity -0.111 0.243 -9999.0 0.0 -0.57 56.0 56.0 Nephrin/NEPH1/podocin/NCK1-2 -0.116 0.182 -9999.0 0.0 -0.441 50.0 50.0 Nephrin/NEPH1/beta Arrestin2 -0.092 0.187 -9999.0 0.0 -0.417 50.0 50.0 NPHS1 -0.14 0.292 -9999.0 0.0 -0.718 55.0 55.0 Nephrin/NEPH1/podocin -0.105 0.195 -9999.0 0.0 -0.444 50.0 50.0 TJP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 -0.129 0.199 -9999.0 0.0 -0.483 50.0 50.0 CD2AP 0.01 0.045 -9999.0 0.0 -0.738 1.0 1.0 Nephrin/NEPH1/podocin/GRB2 -0.129 0.199 -9999.0 0.0 -0.483 50.0 50.0 GRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.104 0.205 -9999.0 0.0 -0.457 51.0 51.0 cytoskeleton organization -0.086 0.187 -9999.0 0.0 -0.638 12.0 12.0 Nephrin/NEPH1 -0.081 0.184 -9999.0 0.0 -0.425 56.0 56.0 Nephrin/NEPH1/ZO-1 -0.098 0.196 -9999.0 0.0 -0.489 50.0 50.0