Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.067 0.263 -9999.0 0.0 -0.692 34.0 34.0 IHH -0.067 0.201 -9999.0 0.0 -0.562 37.0 37.0 SHH Np/Cholesterol/GAS1 -0.036 0.133 -9999.0 0.0 -0.5 10.0 10.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.036 0.132 0.496 10.0 -9999.0 0.0 10.0 SMO/beta Arrestin2 -0.035 0.175 -9999.0 0.0 -0.603 11.0 11.0 SMO -0.043 0.184 -9999.0 0.0 -0.551 18.0 18.0 AKT1 0.001 0.085 -9999.0 0.0 -0.341 1.0 1.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.019 0.13 -9999.0 0.0 -0.53 16.0 16.0 ADRBK1 0.01 0.045 -9999.0 0.0 -0.738 1.0 1.0 heart looping -0.042 0.181 -9999.0 0.0 -0.541 18.0 18.0 STIL -0.131 0.242 -9999.0 0.0 -0.594 36.0 36.0 DHH N/PTCH2 -0.052 0.188 -9999.0 0.0 -0.532 35.0 35.0 DHH N/PTCH1 -0.037 0.168 -9999.0 0.0 -0.616 10.0 10.0 PIK3CA 0.01 0.045 -9999.0 0.0 -0.738 1.0 1.0 DHH -0.0 0.087 -9999.0 0.0 -0.568 6.0 6.0 PTHLH -0.07 0.27 -9999.0 0.0 -0.956 14.0 14.0 determination of left/right symmetry -0.042 0.181 -9999.0 0.0 -0.541 18.0 18.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.069 0.266 -9999.0 0.0 -0.942 14.0 14.0 IHH N/Hhip -0.126 0.221 -9999.0 0.0 -0.433 88.0 88.0 DHH N/Hhip -0.084 0.168 -9999.0 0.0 -0.351 76.0 76.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.042 0.181 -9999.0 0.0 -0.541 18.0 18.0 pancreas development -0.117 0.217 -9999.0 0.0 -0.481 72.0 72.0 HHAT 0.009 0.042 -9999.0 0.0 -0.482 2.0 2.0 PI3K 0.016 0.035 -9999.0 0.0 -0.557 1.0 1.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.028 0.148 -9999.0 0.0 -0.546 20.0 20.0 somite specification -0.042 0.181 -9999.0 0.0 -0.541 18.0 18.0 SHH Np/Cholesterol/PTCH1 -0.05 0.173 -9999.0 0.0 -0.527 18.0 18.0 SHH Np/Cholesterol/PTCH2 -0.062 0.164 -9999.0 0.0 -0.443 33.0 33.0 SHH Np/Cholesterol/Megalin -0.092 0.19 -9999.0 0.0 -0.461 47.0 47.0 SHH -0.025 0.129 -9999.0 0.0 -0.366 33.0 33.0 catabolic process -0.04 0.176 -9999.0 0.0 -0.663 8.0 8.0 SMO/Vitamin D3 -0.05 0.182 -9999.0 0.0 -0.552 18.0 18.0 SHH Np/Cholesterol/Hhip -0.083 0.168 -9999.0 0.0 -0.518 19.0 19.0 LRP2 -0.116 0.277 -9999.0 0.0 -0.712 48.0 48.0 receptor-mediated endocytosis -0.087 0.201 -9999.0 0.0 -0.517 30.0 30.0 SHH Np/Cholesterol/BOC -0.031 0.123 -9999.0 0.0 -0.46 9.0 9.0 SHH Np/Cholesterol/CDO -0.023 0.114 -9999.0 0.0 -0.447 8.0 8.0 mesenchymal cell differentiation 0.083 0.166 0.514 19.0 -9999.0 0.0 19.0 mol:Vitamin D3 -0.048 0.175 -9999.0 0.0 -0.53 18.0 18.0 IHH N/PTCH2 -0.094 0.221 -9999.0 0.0 -0.467 64.0 64.0 CDON -0.004 0.103 -9999.0 0.0 -0.629 7.0 7.0 IHH N/PTCH1 -0.041 0.179 -9999.0 0.0 -0.673 8.0 8.0 Megalin/LRPAP1 -0.079 0.211 -9999.0 0.0 -0.534 48.0 48.0 PTCH2 -0.068 0.23 -9999.0 0.0 -0.721 30.0 30.0 SHH Np/Cholesterol -0.034 0.095 -9999.0 0.0 -0.462 4.0 4.0 PTCH1 -0.041 0.177 -9999.0 0.0 -0.667 8.0 8.0 HHIP -0.118 0.218 -9999.0 0.0 -0.482 72.0 72.0