Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.023 0.039 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation -0.006 0.041 -9999.0 0.0 -0.405 1.0 1.0 CYFIP2 0.001 0.08 -9999.0 0.0 -0.525 6.0 6.0 ENAH 0.049 0.055 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.021 0.143 -9999.0 0.0 -0.602 15.0 15.0 EPHA2 0.008 0.054 -9999.0 0.0 -0.61 2.0 2.0 MYO6 0.027 0.05 -9999.0 0.0 -0.386 2.0 2.0 CTNNB1 0.01 0.045 -9999.0 0.0 -0.738 1.0 1.0 ABI1/Sra1/Nap1 -0.007 0.047 -9999.0 0.0 -0.477 1.0 1.0 AQP5 -0.157 0.195 -9999.0 0.0 -0.414 91.0 91.0 CTNND1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.028 0.043 -9999.0 0.0 -0.377 1.0 1.0 regulation of calcium-dependent cell-cell adhesion 0.023 0.06 -9999.0 0.0 -0.399 3.0 3.0 EGF -0.074 0.231 -9999.0 0.0 -0.692 33.0 33.0 NCKAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.032 0.106 -9999.0 0.0 -0.444 13.0 13.0 cortical microtubule organization -0.006 0.041 -9999.0 0.0 -0.405 1.0 1.0 GO:0000145 0.027 0.041 -9999.0 0.0 -0.36 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.006 0.041 -9999.0 0.0 -0.409 1.0 1.0 MLLT4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.012 0.058 -9999.0 0.0 -0.37 1.0 1.0 ARF6 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.021 0.07 -9999.0 0.0 -0.432 6.0 6.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.033 0.057 -9999.0 0.0 -0.345 1.0 1.0 PVRL2 0.001 0.09 -9999.0 0.0 -0.738 4.0 4.0 ZYX 0.029 0.044 -9999.0 0.0 -0.383 1.0 1.0 ARF6/GTP -0.009 0.059 -9999.0 0.0 -0.396 6.0 6.0 CDH1 0.002 0.072 -9999.0 0.0 -0.482 6.0 6.0 EGFR/EGFR/EGF/EGF -0.062 0.142 -9999.0 0.0 -0.407 33.0 33.0 RhoA/GDP -0.006 0.038 -9999.0 0.0 -0.379 1.0 1.0 actin cytoskeleton organization 0.031 0.053 -9999.0 0.0 -0.348 2.0 2.0 IGF-1R heterotetramer 0.01 0.045 -9999.0 0.0 -0.737 1.0 1.0 GIT1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.01 0.045 -9999.0 0.0 -0.738 1.0 1.0 IGF1 -0.077 0.23 -9999.0 0.0 -0.648 37.0 37.0 DIAPH1 -0.012 0.082 -9999.0 0.0 -0.592 5.0 5.0 Wnt receptor signaling pathway 0.006 0.041 0.405 1.0 -9999.0 0.0 1.0 RHOA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.012 0.058 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.031 0.054 -9999.0 0.0 -0.356 2.0 2.0 EFNA1 -0.001 0.1 -9999.0 0.0 -0.738 5.0 5.0 LPP 0.022 0.093 -9999.0 0.0 -0.477 7.0 7.0 Ephrin A1/EPHA2 -0.015 0.068 -9999.0 0.0 -0.376 8.0 8.0 SEC6/SEC8 -0.01 0.051 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.023 0.061 -9999.0 0.0 -0.406 3.0 3.0 HGF/MET -0.064 0.145 -9999.0 0.0 -0.388 42.0 42.0 HGF -0.003 0.105 -9999.0 0.0 -0.696 6.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.023 0.039 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.06 0.055 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.026 0.044 -9999.0 0.0 -0.365 1.0 1.0 KIFC3 0.027 0.05 -9999.0 0.0 -0.386 2.0 2.0 NCK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.024 0.062 -9999.0 0.0 -0.387 4.0 4.0 NCK1/GIT1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.006 0.041 -9999.0 0.0 -0.405 1.0 1.0 EXOC4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.029 0.044 -9999.0 0.0 -0.383 1.0 1.0 PIP5K1C 0.029 0.044 -9999.0 0.0 -0.383 1.0 1.0 LIMA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.045 0.063 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.041 0.047 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 -0.049 0.121 -9999.0 0.0 -0.387 26.0 26.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.01 0.069 -9999.0 0.0 -0.557 4.0 4.0 MET -0.092 0.259 -9999.0 0.0 -0.738 38.0 38.0 PLEKHA7 0.028 0.046 -9999.0 0.0 -0.383 1.0 1.0 mol:GTP -0.01 0.064 -9999.0 0.0 -0.429 6.0 6.0 establishment of epithelial cell apical/basal polarity 0.046 0.059 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.023 0.039 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion 0.031 0.053 -9999.0 0.0 -0.348 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.023 0.039 -9999.0 0.0 -9999.0 0.0 0.0