E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.006 0.079 -9999.0 0.0 -0.303 15.0 15.0 KLHL20 0.026 0.062 0.176 10.0 -0.188 2.0 12.0 CYFIP2 0.021 0.046 -9999.0 0.0 -0.348 4.0 4.0 Rac1/GDP 0.033 0.074 0.25 7.0 -0.233 4.0 11.0 ENAH 0.01 0.074 -9999.0 0.0 -0.307 13.0 13.0 AP1M1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.018 0.035 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.01 0.027 -9999.0 0.0 -0.134 3.0 3.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.055 0.047 -9999.0 0.0 -0.197 6.0 6.0 RAPGEF1 0.013 0.088 0.232 2.0 -0.307 10.0 12.0 CTNND1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.012 0.087 -9999.0 0.0 -0.314 17.0 17.0 CRK 0.002 0.072 -9999.0 0.0 -0.332 9.0 9.0 E-cadherin/gamma catenin/alpha catenin 0.044 0.045 -9999.0 0.0 -0.267 4.0 4.0 alphaE/beta7 Integrin 0.036 0.028 -9999.0 0.0 -0.26 2.0 2.0 IQGAP1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.048 0.018 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 0.007 0.079 -9999.0 0.0 -0.308 15.0 15.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 0.001 0.021 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.032 0.02 -9999.0 0.0 -0.169 2.0 2.0 PI3K 0.005 0.028 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.031 0.046 -9999.0 0.0 -0.313 4.0 4.0 TIAM1 0.024 0.031 -9999.0 0.0 -0.325 2.0 2.0 E-cadherin(dimer)/Ca2+ 0.054 0.038 -9999.0 0.0 -0.187 4.0 4.0 AKT1 0.005 0.036 0.136 2.0 -9999.0 0.0 2.0 PIK3R1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.021 0.048 -9999.0 0.0 -0.37 4.0 4.0 RhoA/GDP 0.039 0.077 0.247 8.0 -0.231 3.0 11.0 actin cytoskeleton organization 0.023 0.05 0.147 12.0 -0.139 2.0 14.0 CDC42/GDP 0.038 0.079 0.247 8.0 -0.241 1.0 9.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.014 0.035 -9999.0 0.0 -0.243 4.0 4.0 ITGB7 0.024 0.034 -9999.0 0.0 -0.37 2.0 2.0 RAC1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.058 0.041 -9999.0 0.0 -0.2 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.04 0.033 -9999.0 0.0 -0.185 4.0 4.0 mol:GDP 0.027 0.084 0.251 8.0 -0.265 4.0 12.0 CDC42/GTP/IQGAP1 0.035 0.011 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.023 0.031 -9999.0 0.0 -0.325 2.0 2.0 p120 catenin/RhoA/GDP 0.048 0.078 0.258 7.0 -9999.0 0.0 7.0 RAC1/GTP/IQGAP1 0.034 0.013 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.04 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.019 0.036 0.118 9.0 -0.113 1.0 10.0 NME1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.009 0.078 -9999.0 0.0 -0.313 14.0 14.0 regulation of cell-cell adhesion 0.011 0.029 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.012 0.024 0.071 5.0 -9999.0 0.0 5.0 Rap1/GTP 0.035 0.059 0.228 3.0 -9999.0 0.0 3.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.06 0.053 -9999.0 0.0 -0.232 4.0 4.0 CCND1 0.022 0.042 0.135 9.0 -0.138 1.0 10.0 VAV2 0.02 0.121 -9999.0 0.0 -0.532 5.0 5.0 RAP1/GDP 0.046 0.072 0.261 6.0 -9999.0 0.0 6.0 adherens junction assembly 0.009 0.076 -9999.0 0.0 -0.304 14.0 14.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.05 0.052 -9999.0 0.0 -0.225 4.0 4.0 E-cadherin/beta catenin 0.006 0.04 -9999.0 0.0 -0.269 5.0 5.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.005 0.08 -9999.0 0.0 -0.344 10.0 10.0 PIK3CA 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.018 0.056 -9999.0 0.0 -0.26 7.0 7.0 E-cadherin/beta catenin/alpha catenin 0.046 0.038 -9999.0 0.0 -0.22 4.0 4.0 ITGAE 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.012 0.088 -9999.0 0.0 -0.32 17.0 17.0