Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.03 0.129 -9999.0 0.0 -0.472 11.0 11.0 IHH -0.027 0.144 -9999.0 0.0 -0.385 35.0 35.0 SHH Np/Cholesterol/GAS1 -0.01 0.084 -9999.0 0.0 -0.199 42.0 42.0 LRPAP1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.01 0.083 0.198 42.0 -9999.0 0.0 42.0 SMO/beta Arrestin2 -0.022 0.134 -9999.0 0.0 -0.411 15.0 15.0 SMO -0.033 0.13 -9999.0 0.0 -0.36 30.0 30.0 AKT1 -0.02 0.136 -9999.0 0.0 -0.463 17.0 17.0 ARRB2 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.005 0.09 -9999.0 0.0 -0.353 16.0 16.0 ADRBK1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.031 0.129 -9999.0 0.0 -0.356 30.0 30.0 STIL -0.058 0.121 0.187 7.0 -0.317 28.0 35.0 DHH N/PTCH2 0.011 0.082 -9999.0 0.0 -0.206 33.0 33.0 DHH N/PTCH1 -0.009 0.109 -9999.0 0.0 -0.335 12.0 12.0 PIK3CA 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.019 0.055 -9999.0 0.0 -0.34 6.0 6.0 PTHLH -0.043 0.169 -9999.0 0.0 -0.639 13.0 13.0 determination of left/right symmetry -0.031 0.129 -9999.0 0.0 -0.356 30.0 30.0 PIK3R1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.043 0.167 -9999.0 0.0 -0.633 13.0 13.0 IHH N/Hhip -0.072 0.169 -9999.0 0.0 -0.326 76.0 76.0 DHH N/Hhip -0.04 0.135 -9999.0 0.0 -0.264 71.0 71.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.031 0.129 -9999.0 0.0 -0.356 30.0 30.0 pancreas development -0.071 0.171 -9999.0 0.0 -0.37 67.0 67.0 HHAT 0.024 0.034 -9999.0 0.0 -0.37 2.0 2.0 PI3K 0.037 0.014 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.002 0.093 -9999.0 0.0 -0.345 18.0 18.0 somite specification -0.031 0.129 -9999.0 0.0 -0.356 30.0 30.0 SHH Np/Cholesterol/PTCH1 -0.031 0.109 -9999.0 0.0 -0.306 20.0 20.0 SHH Np/Cholesterol/PTCH2 -0.017 0.083 -9999.0 0.0 -0.173 57.0 57.0 SHH Np/Cholesterol/Megalin -0.027 0.092 -9999.0 0.0 -0.176 69.0 69.0 SHH -0.018 0.087 -9999.0 0.0 -0.261 30.0 30.0 catabolic process -0.02 0.111 -9999.0 0.0 -0.275 33.0 33.0 SMO/Vitamin D3 -0.036 0.124 -9999.0 0.0 -0.363 19.0 19.0 SHH Np/Cholesterol/Hhip -0.049 0.123 -9999.0 0.0 -0.232 78.0 78.0 LRP2 -0.029 0.121 -9999.0 0.0 -0.288 48.0 48.0 receptor-mediated endocytosis -0.053 0.125 -9999.0 0.0 -0.353 23.0 23.0 SHH Np/Cholesterol/BOC -0.009 0.084 -9999.0 0.0 -0.202 41.0 41.0 SHH Np/Cholesterol/CDO -0.003 0.074 -9999.0 0.0 -0.192 34.0 34.0 mesenchymal cell differentiation 0.049 0.122 0.23 78.0 -9999.0 0.0 78.0 mol:Vitamin D3 -0.028 0.114 0.2 7.0 -0.307 20.0 27.0 IHH N/PTCH2 -0.022 0.114 -9999.0 0.0 -0.233 56.0 56.0 CDON 0.018 0.055 -9999.0 0.0 -0.318 7.0 7.0 IHH N/PTCH1 -0.014 0.115 -9999.0 0.0 -0.277 33.0 33.0 Megalin/LRPAP1 -0.002 0.09 -9999.0 0.0 -0.197 47.0 47.0 PTCH2 -0.004 0.094 -9999.0 0.0 -0.282 28.0 28.0 SHH Np/Cholesterol -0.008 0.067 -9999.0 0.0 -0.195 30.0 30.0 PTCH1 -0.02 0.111 -9999.0 0.0 -0.276 33.0 33.0 HHIP -0.071 0.171 -9999.0 0.0 -0.37 67.0 67.0