Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.019 0.028 -9999.0 0.0 -0.19 4.0 4.0 epithelial cell differentiation 0.049 0.036 -9999.0 0.0 -0.186 4.0 4.0 CYFIP2 0.021 0.046 -9999.0 0.0 -0.348 4.0 4.0 ENAH -0.006 0.051 0.241 3.0 -0.233 1.0 4.0 EGFR 0.013 0.07 -9999.0 0.0 -0.36 9.0 9.0 EPHA2 0.024 0.031 -9999.0 0.0 -0.325 2.0 2.0 MYO6 -0.005 0.042 0.178 10.0 -9999.0 0.0 10.0 CTNNB1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.047 0.036 -9999.0 0.0 -0.205 4.0 4.0 AQP5 -0.114 0.187 -9999.0 0.0 -0.4 76.0 76.0 CTNND1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.006 0.04 0.176 9.0 -9999.0 0.0 9.0 regulation of calcium-dependent cell-cell adhesion -0.008 0.045 0.176 9.0 -0.191 1.0 10.0 EGF -0.012 0.105 -9999.0 0.0 -0.296 32.0 32.0 NCKAP1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.009 0.091 -9999.0 0.0 -0.391 11.0 11.0 cortical microtubule organization 0.049 0.036 -9999.0 0.0 -0.186 4.0 4.0 GO:0000145 -0.006 0.038 0.164 9.0 -9999.0 0.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.054 0.038 -9999.0 0.0 -0.187 4.0 4.0 MLLT4 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.02 0.028 -9999.0 0.0 -0.312 1.0 1.0 ARF6 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.06 0.039 -9999.0 0.0 -0.2 1.0 1.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.006 0.038 0.175 8.0 -9999.0 0.0 8.0 PVRL2 0.025 0.02 -9999.0 0.0 -0.279 1.0 1.0 ZYX -0.005 0.042 0.178 10.0 -9999.0 0.0 10.0 ARF6/GTP 0.063 0.042 -9999.0 0.0 -0.188 1.0 1.0 CDH1 0.021 0.048 -9999.0 0.0 -0.37 4.0 4.0 EGFR/EGFR/EGF/EGF 0.013 0.074 -9999.0 0.0 -0.233 3.0 3.0 RhoA/GDP 0.05 0.036 -9999.0 0.0 -0.179 3.0 3.0 actin cytoskeleton organization -0.006 0.04 0.165 10.0 -9999.0 0.0 10.0 IGF-1R heterotetramer 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.018 0.117 -9999.0 0.0 -0.311 37.0 37.0 DIAPH1 0.012 0.153 -9999.0 0.0 -0.534 12.0 12.0 Wnt receptor signaling pathway -0.049 0.036 0.186 4.0 -9999.0 0.0 4.0 RHOA 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.02 0.028 -9999.0 0.0 -0.297 1.0 1.0 CTNNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.007 0.041 0.166 10.0 -9999.0 0.0 10.0 EFNA1 0.023 0.037 -9999.0 0.0 -0.279 4.0 4.0 LPP -0.011 0.046 0.171 8.0 -0.242 2.0 10.0 Ephrin A1/EPHA2 0.039 0.045 -9999.0 0.0 -0.336 1.0 1.0 SEC6/SEC8 -0.016 0.021 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.008 0.045 0.177 9.0 -0.194 1.0 10.0 HGF/MET 0.02 0.065 -9999.0 0.0 -0.243 1.0 1.0 HGF 0.021 0.042 -9999.0 0.0 -0.279 5.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.019 0.029 -9999.0 0.0 -0.192 4.0 4.0 actin cable formation 0.018 0.08 0.25 14.0 -0.291 2.0 16.0 KIAA1543 -0.005 0.04 0.167 10.0 -9999.0 0.0 10.0 KIFC3 -0.008 0.037 0.177 7.0 -9999.0 0.0 7.0 NCK1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.006 0.044 0.178 10.0 -9999.0 0.0 10.0 NCK1/GIT1 0.04 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.049 0.036 -9999.0 0.0 -0.186 4.0 4.0 EXOC4 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.007 0.039 0.179 8.0 -9999.0 0.0 8.0 PIP5K1C -0.006 0.041 0.177 9.0 -9999.0 0.0 9.0 LIMA1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.0 0.067 0.308 4.0 -0.267 1.0 5.0 adherens junction assembly -0.009 0.091 0.278 2.0 -0.483 5.0 7.0 IGF-1R heterotetramer/IGF1 0.018 0.072 -9999.0 0.0 -0.289 1.0 1.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.036 0.019 -9999.0 0.0 -0.191 1.0 1.0 MET -0.007 0.094 -9999.0 0.0 -0.279 29.0 29.0 PLEKHA7 -0.005 0.042 0.178 10.0 -9999.0 0.0 10.0 mol:GTP 0.057 0.038 -9999.0 0.0 -0.199 1.0 1.0 establishment of epithelial cell apical/basal polarity 0.017 0.086 0.299 12.0 -9999.0 0.0 12.0 cortical actin cytoskeleton stabilization 0.019 0.028 -9999.0 0.0 -0.19 4.0 4.0 regulation of cell-cell adhesion -0.006 0.04 0.165 10.0 -9999.0 0.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.019 0.029 -9999.0 0.0 -0.192 4.0 4.0