E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.045 0.002 -9999.0 0.0 -9999.0 0.0 0.0 KLHL20 -0.009 0.021 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.073 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.045 0.002 -9999.0 0.0 -9999.0 0.0 0.0 AP1M1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.0 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.001 0.014 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.019 0.084 -9999.0 0.0 -0.489 14.0 14.0 RAPGEF1 0.057 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CRK 0.052 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 alphaE/beta7 Integrin -0.026 0.11 -9999.0 0.0 -0.624 14.0 14.0 IQGAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 0.045 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.001 0.016 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 -0.078 0.071 -9999.0 0.0 -0.497 1.0 1.0 PI3K -0.002 0.021 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TIAM1 -0.168 0.163 -9999.0 0.0 -0.312 276.0 276.0 E-cadherin(dimer)/Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 -0.001 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.073 0.009 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.007 0.016 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GDP 0.073 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ITGB7 -0.024 0.15 -9999.0 0.0 -0.512 35.0 35.0 RAC1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.072 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP -0.0 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAC1/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.013 0.032 -9999.0 0.0 -0.146 11.0 11.0 NME1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.045 0.002 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion -0.0 0.002 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.002 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.0 0.003 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.018 0.078 -9999.0 0.0 -0.457 14.0 14.0 CCND1 0.015 0.039 -9999.0 0.0 -0.179 11.0 11.0 VAV2 0.056 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1/GDP 0.0 0.004 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.045 0.001 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.016 0.074 -9999.0 0.0 -0.432 14.0 14.0 E-cadherin/beta catenin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.044 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.008 0.064 -9999.0 0.0 -0.814 3.0 3.0 Rac1/GTP -0.017 0.033 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ITGAE 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0