Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.108 0.256 -9999.0 0.0 -0.682 35.0 35.0 IHH -0.203 0.366 -9999.0 0.0 -0.834 123.0 123.0 SHH Np/Cholesterol/GAS1 -0.103 0.202 -9999.0 0.0 -0.51 96.0 96.0 LRPAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.102 0.2 0.506 96.0 -9999.0 0.0 96.0 SMO/beta Arrestin2 -0.095 0.24 -9999.0 0.0 -0.478 126.0 126.0 SMO -0.107 0.252 -9999.0 0.0 -0.509 127.0 127.0 AKT1 -0.027 0.123 -9999.0 0.0 -0.661 2.0 2.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.0 0.104 -9999.0 0.0 -0.814 8.0 8.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.105 0.249 -9999.0 0.0 -0.501 127.0 127.0 STIL -0.077 0.197 -9999.0 0.0 -0.592 18.0 18.0 DHH N/PTCH2 -0.106 0.239 -9999.0 0.0 -0.636 82.0 82.0 DHH N/PTCH1 -0.099 0.224 -9999.0 0.0 -0.448 130.0 130.0 PIK3CA 0.008 0.064 -9999.0 0.0 -0.814 3.0 3.0 DHH 0.007 0.074 -9999.0 0.0 -0.814 4.0 4.0 PTHLH -0.155 0.364 -9999.0 0.0 -1.159 35.0 35.0 determination of left/right symmetry -0.105 0.249 -9999.0 0.0 -0.501 127.0 127.0 PIK3R1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.152 0.358 -9999.0 0.0 -1.134 35.0 35.0 IHH N/Hhip -0.382 0.395 -9999.0 0.0 -0.729 263.0 263.0 DHH N/Hhip -0.249 0.309 -9999.0 0.0 -0.629 195.0 195.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.105 0.249 -9999.0 0.0 -0.501 127.0 127.0 pancreas development -0.314 0.4 -9999.0 0.0 -0.807 195.0 195.0 HHAT 0.012 0.037 -9999.0 0.0 -0.814 1.0 1.0 PI3K -0.004 0.048 -9999.0 0.0 -0.624 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.146 0.326 -9999.0 0.0 -0.814 95.0 95.0 somite specification -0.105 0.249 -9999.0 0.0 -0.501 127.0 127.0 SHH Np/Cholesterol/PTCH1 -0.087 0.202 -9999.0 0.0 -0.614 17.0 17.0 SHH Np/Cholesterol/PTCH2 -0.087 0.188 -9999.0 0.0 -0.507 81.0 81.0 SHH Np/Cholesterol/Megalin -0.141 0.227 -9999.0 0.0 -0.511 134.0 134.0 SHH 0.007 0.049 -9999.0 0.0 -0.624 1.0 1.0 catabolic process -0.113 0.247 -9999.0 0.0 -0.505 126.0 126.0 SMO/Vitamin D3 -0.091 0.221 -9999.0 0.0 -0.651 17.0 17.0 SHH Np/Cholesterol/Hhip -0.203 0.244 -9999.0 0.0 -0.503 195.0 195.0 LRP2 -0.209 0.367 -9999.0 0.0 -0.814 133.0 133.0 receptor-mediated endocytosis -0.199 0.234 -9999.0 0.0 -0.713 49.0 49.0 SHH Np/Cholesterol/BOC -0.014 0.073 -9999.0 0.0 -0.518 9.0 9.0 SHH Np/Cholesterol/CDO -0.154 0.231 -9999.0 0.0 -0.508 146.0 146.0 mesenchymal cell differentiation 0.201 0.242 0.499 195.0 -9999.0 0.0 195.0 mol:Vitamin D3 -0.086 0.205 -9999.0 0.0 -0.425 86.0 86.0 IHH N/PTCH2 -0.229 0.343 -9999.0 0.0 -0.658 181.0 181.0 CDON -0.229 0.377 -9999.0 0.0 -0.814 145.0 145.0 IHH N/PTCH1 -0.115 0.25 -9999.0 0.0 -0.512 126.0 126.0 Megalin/LRPAP1 -0.168 0.277 -9999.0 0.0 -0.624 133.0 133.0 PTCH2 -0.121 0.305 -9999.0 0.0 -0.814 80.0 80.0 SHH Np/Cholesterol -0.006 0.035 -9999.0 0.0 -0.505 1.0 1.0 PTCH1 -0.113 0.248 -9999.0 0.0 -0.507 126.0 126.0 HHIP -0.314 0.401 -9999.0 0.0 -0.809 195.0 195.0