E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.03 0.029 -9999.0 0.0 -9999.0 0.0 0.0 KLHL20 0.014 0.05 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.038 0.041 0.258 2.0 -9999.0 0.0 2.0 ENAH 0.027 0.027 -9999.0 0.0 -9999.0 0.0 0.0 AP1M1 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.035 0.015 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.008 0.032 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.055 0.072 -9999.0 0.0 -0.399 11.0 11.0 RAPGEF1 0.026 0.033 0.267 1.0 -9999.0 0.0 1.0 CTNND1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.032 0.034 -9999.0 0.0 -0.313 1.0 1.0 CRK 0.026 0.026 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin 0.051 0.016 -9999.0 0.0 -9999.0 0.0 0.0 alphaE/beta7 Integrin 0.021 0.083 -9999.0 0.0 -0.503 11.0 11.0 IQGAP1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.05 0.014 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 0.029 0.033 -9999.0 0.0 -9999.0 0.0 0.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 0.008 0.016 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.055 0.03 -9999.0 0.0 -0.399 1.0 1.0 PI3K 0.016 0.022 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.038 0.011 -9999.0 0.0 -9999.0 0.0 0.0 TIAM1 -0.054 0.077 -9999.0 0.0 -0.668 1.0 1.0 E-cadherin(dimer)/Ca2+ 0.061 0.017 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.018 0.021 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.045 0.067 0.418 8.0 -9999.0 0.0 8.0 actin cytoskeleton organization 0.013 0.041 0.189 3.0 -9999.0 0.0 3.0 CDC42/GDP 0.046 0.075 0.457 10.0 -9999.0 0.0 10.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.023 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ITGB7 0.004 0.107 -9999.0 0.0 -0.641 12.0 12.0 RAC1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.066 0.019 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.046 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.035 0.081 0.484 10.0 -9999.0 0.0 10.0 CDC42/GTP/IQGAP1 0.036 0.008 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.045 0.043 -9999.0 0.0 -9999.0 0.0 0.0 RAC1/GTP/IQGAP1 0.035 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.037 0.012 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.012 0.036 0.199 5.0 -9999.0 0.0 5.0 NME1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.029 0.033 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion 0.025 0.011 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.007 0.022 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.042 0.027 0.245 2.0 -9999.0 0.0 2.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.064 0.072 -9999.0 0.0 -0.378 11.0 11.0 CCND1 0.013 0.039 0.189 4.0 -9999.0 0.0 4.0 VAV2 0.007 0.14 -9999.0 0.0 -0.526 27.0 27.0 RAP1/GDP 0.048 0.04 0.296 5.0 -9999.0 0.0 5.0 adherens junction assembly 0.029 0.032 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.053 0.067 -9999.0 0.0 -0.364 11.0 11.0 E-cadherin/beta catenin 0.015 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.03 0.03 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.023 0.054 -9999.0 0.0 -0.668 3.0 3.0 Rac1/GTP -0.006 0.076 -9999.0 0.0 -0.312 3.0 3.0 E-cadherin/beta catenin/alpha catenin 0.053 0.014 -9999.0 0.0 -9999.0 0.0 0.0 ITGAE 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.033 0.034 -9999.0 0.0 -0.319 1.0 1.0