Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.087 0.207 -9999.0 0.0 -0.615 30.0 30.0 IHH -0.153 0.312 -9999.0 0.0 -0.695 121.0 121.0 SHH Np/Cholesterol/GAS1 -0.051 0.155 -9999.0 0.0 -0.39 82.0 82.0 LRPAP1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.051 0.154 0.387 82.0 -9999.0 0.0 82.0 SMO/beta Arrestin2 -0.075 0.204 -9999.0 0.0 -0.414 111.0 111.0 SMO -0.096 0.206 -9999.0 0.0 -0.433 118.0 118.0 AKT1 -0.016 0.105 -9999.0 0.0 -0.607 2.0 2.0 ARRB2 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.016 0.088 -9999.0 0.0 -0.668 8.0 8.0 ADRBK1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.094 0.204 -9999.0 0.0 -0.428 118.0 118.0 STIL -0.065 0.158 0.267 1.0 -0.336 72.0 73.0 DHH N/PTCH2 -0.05 0.203 -9999.0 0.0 -0.505 80.0 80.0 DHH N/PTCH1 -0.076 0.188 -9999.0 0.0 -0.358 144.0 144.0 PIK3CA 0.023 0.054 -9999.0 0.0 -0.668 3.0 3.0 DHH 0.021 0.063 -9999.0 0.0 -0.668 4.0 4.0 PTHLH -0.136 0.306 -9999.0 0.0 -1.026 32.0 32.0 determination of left/right symmetry -0.094 0.204 -9999.0 0.0 -0.428 118.0 118.0 PIK3R1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.134 0.302 -9999.0 0.0 -1.008 32.0 32.0 IHH N/Hhip -0.291 0.329 -9999.0 0.0 -0.586 258.0 258.0 DHH N/Hhip -0.171 0.263 -9999.0 0.0 -0.502 189.0 189.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.094 0.204 -9999.0 0.0 -0.428 118.0 118.0 pancreas development -0.248 0.329 -9999.0 0.0 -0.665 188.0 188.0 HHAT 0.024 0.032 -9999.0 0.0 -0.668 1.0 1.0 PI3K 0.036 0.043 -9999.0 0.0 -0.503 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.097 0.259 -9999.0 0.0 -0.624 93.0 93.0 somite specification -0.094 0.204 -9999.0 0.0 -0.428 118.0 118.0 SHH Np/Cholesterol/PTCH1 -0.07 0.158 -9999.0 0.0 -0.333 111.0 111.0 SHH Np/Cholesterol/PTCH2 -0.043 0.148 -9999.0 0.0 -0.375 79.0 79.0 SHH Np/Cholesterol/Megalin -0.081 0.177 -9999.0 0.0 -0.376 126.0 126.0 SHH -0.005 0.029 -9999.0 0.0 -0.503 1.0 1.0 catabolic process -0.094 0.201 -9999.0 0.0 -0.401 141.0 141.0 SMO/Vitamin D3 -0.076 0.182 -9999.0 0.0 -0.38 109.0 109.0 SHH Np/Cholesterol/Hhip -0.137 0.199 -9999.0 0.0 -0.386 188.0 188.0 LRP2 -0.155 0.303 -9999.0 0.0 -0.656 131.0 131.0 receptor-mediated endocytosis -0.14 0.209 -9999.0 0.0 -0.566 48.0 48.0 SHH Np/Cholesterol/BOC 0.014 0.055 -9999.0 0.0 -0.367 9.0 9.0 SHH Np/Cholesterol/CDO -0.094 0.183 -9999.0 0.0 -0.373 143.0 143.0 mesenchymal cell differentiation 0.137 0.197 0.383 188.0 -9999.0 0.0 188.0 mol:Vitamin D3 -0.065 0.166 -9999.0 0.0 -0.336 111.0 111.0 IHH N/PTCH2 -0.169 0.285 -9999.0 0.0 -0.526 179.0 179.0 CDON -0.176 0.315 -9999.0 0.0 -0.665 144.0 144.0 IHH N/PTCH1 -0.091 0.206 -9999.0 0.0 -0.406 141.0 141.0 Megalin/LRPAP1 -0.102 0.236 -9999.0 0.0 -0.491 131.0 131.0 PTCH2 -0.084 0.254 -9999.0 0.0 -0.664 79.0 79.0 SHH Np/Cholesterol 0.01 0.022 -9999.0 0.0 -0.398 1.0 1.0 PTCH1 -0.094 0.202 -9999.0 0.0 -0.403 141.0 141.0 HHIP -0.248 0.329 -9999.0 0.0 -0.666 188.0 188.0