Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation 0.055 0.016 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.022 0.078 0.46 11.0 -9999.0 0.0 11.0 EGFR 0.019 0.07 -9999.0 0.0 -0.668 5.0 5.0 EPHA2 0.026 0.012 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 0.031 0.065 0.421 11.0 -9999.0 0.0 11.0 CTNNB1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.053 0.013 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 0.002 0.111 -9999.0 0.0 -0.528 19.0 19.0 CTNND1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.024 0.047 0.377 7.0 -9999.0 0.0 7.0 regulation of calcium-dependent cell-cell adhesion -0.01 0.054 0.395 5.0 -9999.0 0.0 5.0 EGF -0.076 0.244 -9999.0 0.0 -0.663 72.0 72.0 NCKAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.041 0.169 -9999.0 0.0 -0.526 49.0 49.0 cortical microtubule organization 0.055 0.016 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 0.012 0.047 0.367 7.0 -9999.0 0.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.061 0.017 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP 0.006 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.062 0.024 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.012 0.03 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.02 0.021 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.067 0.027 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF -0.011 0.144 -9999.0 0.0 -0.353 74.0 74.0 RhoA/GDP 0.057 0.016 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.02 0.051 0.384 8.0 -9999.0 0.0 8.0 IGF-1R heterotetramer 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.126 0.285 -9999.0 0.0 -0.665 107.0 107.0 DIAPH1 0.05 0.05 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway -0.055 0.016 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP 0.006 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.021 0.051 0.386 8.0 -9999.0 0.0 8.0 EFNA1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.01 0.06 0.352 4.0 -0.354 8.0 12.0 Ephrin A1/EPHA2 0.047 0.019 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 0.014 0.006 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.01 0.054 0.397 5.0 -9999.0 0.0 5.0 HGF/MET -0.004 0.143 -9999.0 0.0 -0.37 63.0 63.0 HGF -0.072 0.241 -9999.0 0.0 -0.668 69.0 69.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.066 0.133 0.492 30.0 -0.328 1.0 31.0 KIAA1543 0.013 0.053 0.366 8.0 -0.348 1.0 9.0 KIFC3 0.021 0.023 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.024 0.038 0.355 4.0 -9999.0 0.0 4.0 NCK1/GIT1 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.055 0.016 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.021 0.023 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.024 0.047 0.38 7.0 -9999.0 0.0 7.0 LIMA1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.044 0.103 0.441 22.0 -9999.0 0.0 22.0 adherens junction assembly 0.026 0.086 0.457 12.0 -0.563 1.0 13.0 IGF-1R heterotetramer/IGF1 -0.036 0.164 -9999.0 0.0 -0.352 101.0 101.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.038 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.027 0.069 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 0.026 0.053 0.376 8.0 -0.364 1.0 9.0 mol:GTP 0.059 0.024 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.032 0.067 0.481 7.0 -9999.0 0.0 7.0 cortical actin cytoskeleton stabilization 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion 0.02 0.051 0.384 8.0 -9999.0 0.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0