Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Ephrin A  reverse signaling	245.0	1721.0	7.0	-0.418	-0.0	1000.0	-1000.0	-0.011	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	166.0	12971.0	78.0	-0.744	0.236	1000.0	-1000.0	-0.043	-1000.0
Signaling events regulated by Ret tyrosine kinase	144.0	11833.0	82.0	-0.365	0.027	1000.0	-1000.0	-0.057	-1000.0
Reelin signaling pathway	128.0	7220.0	56.0	-0.455	0.061	1000.0	-1000.0	-0.038	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	110.0	7501.0	68.0	-0.731	0.352	1000.0	-1000.0	-0.066	-1000.0
Noncanonical Wnt signaling pathway	101.0	2650.0	26.0	-0.322	0.027	1000.0	-1000.0	-0.038	-1000.0
Wnt signaling	101.0	709.0	7.0	-0.322	0.014	1000.0	-1000.0	-0.016	-1000.0
PDGFR-alpha signaling pathway	94.0	4146.0	44.0	-0.398	0.043	1000.0	-1000.0	-0.045	-1000.0
Signaling events mediated by the Hedgehog family	86.0	4515.0	52.0	-0.291	0.137	1000.0	-1000.0	-0.032	-1000.0
Nongenotropic Androgen signaling	86.0	4517.0	52.0	-0.262	0.191	1000.0	-1000.0	-0.029	-1000.0
FOXA2 and FOXA3 transcription factor networks	83.0	3837.0	46.0	-0.841	0.031	1000.0	-1000.0	-0.076	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	72.0	3920.0	54.0	-0.455	0.039	1000.0	-1000.0	-0.056	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	67.0	2306.0	34.0	-0.103	0.027	1000.0	-1000.0	-0.031	-1000.0
Calcium signaling in the CD4+ TCR pathway	65.0	2039.0	31.0	-0.348	0.027	1000.0	-1000.0	-0.036	-1000.0
Endothelins	63.0	6142.0	96.0	-0.317	0.031	1000.0	-1000.0	-0.048	-1000.0
IGF1 pathway	63.0	3628.0	57.0	-0.139	0.064	1000.0	-1000.0	-0.041	-1000.0
Glypican 1 network	62.0	2985.0	48.0	-0.294	0.052	1000.0	-1000.0	-0.023	-1000.0
IL4-mediated signaling events	59.0	5432.0	91.0	-1.176	0.57	1000.0	-1000.0	-0.07	-1000.0
HIF-1-alpha transcription factor network	57.0	4341.0	76.0	-0.472	0.041	1000.0	-1000.0	-0.052	-1000.0
Ephrin B reverse signaling	53.0	2564.0	48.0	-0.233	0.115	1000.0	-1000.0	-0.028	-1000.0
EPHB forward signaling	53.0	4573.0	85.0	-0.232	0.109	1000.0	-1000.0	-0.061	-1000.0
IL23-mediated signaling events	52.0	3156.0	60.0	-0.265	0.027	1000.0	-1000.0	-0.038	-1000.0
BMP receptor signaling	51.0	4185.0	81.0	-0.441	0.052	1000.0	-1000.0	-0.053	-1000.0
TCR signaling in naïve CD8+ T cells	49.0	4603.0	93.0	-0.153	0.045	1000.0	-1000.0	-0.05	-1000.0
Coregulation of Androgen receptor activity	47.0	3638.0	76.0	-0.664	0.076	1000.0	-1000.0	-0.022	-1000.0
Glucocorticoid receptor regulatory network	47.0	5468.0	114.0	-0.45	0.249	1000.0	-1000.0	-0.057	-1000.0
Arf6 signaling events	44.0	2779.0	62.0	-0.255	0.061	1000.0	-1000.0	-0.03	-1000.0
Signaling mediated by p38-alpha and p38-beta	38.0	1681.0	44.0	-0.222	0.027	1000.0	-1000.0	-0.036	-1000.0
Thromboxane A2 receptor signaling	37.0	3899.0	105.0	-0.164	0.047	1000.0	-1000.0	-0.04	-1000.0
Hedgehog signaling events mediated by Gli proteins	36.0	2376.0	65.0	-0.582	0.064	1000.0	-1000.0	-0.04	-1000.0
IL12-mediated signaling events	34.0	2985.0	87.0	-0.362	0.028	1000.0	-1000.0	-0.06	-1000.0
Ras signaling in the CD4+ TCR pathway	33.0	571.0	17.0	-0.105	0.035	1000.0	-1000.0	-0.025	-1000.0
IL6-mediated signaling events	31.0	2390.0	75.0	-0.148	0.054	1000.0	-1000.0	-0.039	-1000.0
EGFR-dependent Endothelin signaling events	31.0	669.0	21.0	-0.076	0.038	1000.0	-1000.0	-0.045	-1000.0
Syndecan-1-mediated signaling events	28.0	985.0	34.0	-0.075	0.027	1000.0	-1000.0	-0.037	-1000.0
Plasma membrane estrogen receptor signaling	27.0	2385.0	86.0	-0.133	0.049	1000.0	-1000.0	-0.052	-1000.0
Regulation of p38-alpha and p38-beta	26.0	1419.0	54.0	-0.354	0.065	1000.0	-1000.0	-0.046	-1000.0
Regulation of Androgen receptor activity	26.0	1832.0	70.0	-0.441	0.036	1000.0	-1000.0	-0.044	-1000.0
Osteopontin-mediated events	25.0	969.0	38.0	-0.148	0.043	1000.0	-1000.0	-0.039	-1000.0
ErbB2/ErbB3 signaling events	24.0	1616.0	65.0	-0.167	0.037	1000.0	-1000.0	-0.049	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	24.0	2087.0	85.0	-0.218	0.134	1000.0	-1000.0	-0.043	-1000.0
FAS signaling pathway (CD95)	24.0	1167.0	47.0	-0.195	0.044	1000.0	-1000.0	-0.029	-1000.0
LPA receptor mediated events	23.0	2363.0	102.0	-0.151	0.035	1000.0	-1000.0	-0.058	-1000.0
BCR signaling pathway	22.0	2196.0	99.0	-0.099	0.048	1000.0	-1000.0	-0.06	-1000.0
Syndecan-4-mediated signaling events	22.0	1500.0	67.0	-0.155	0.039	1000.0	-1000.0	-0.038	-1000.0
VEGFR1 specific signals	22.0	1263.0	56.0	-0.043	0.058	1000.0	-1000.0	-0.048	-1000.0
IFN-gamma pathway	21.0	1459.0	68.0	-0.167	0.035	1000.0	-1000.0	-0.054	-1000.0
Ceramide signaling pathway	21.0	1600.0	76.0	-0.149	0.075	1000.0	-1000.0	-0.031	-1000.0
Fc-epsilon receptor I signaling in mast cells	19.0	1923.0	97.0	-0.148	0.044	1000.0	-1000.0	-0.056	-1000.0
ceramide signaling pathway	18.0	923.0	49.0	-0.055	0.039	1000.0	-1000.0	-0.032	-1000.0
Angiopoietin receptor Tie2-mediated signaling	18.0	1623.0	88.0	-0.253	0.039	1000.0	-1000.0	-0.063	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	17.0	886.0	52.0	-0.178	0.059	1000.0	-1000.0	-0.026	-1000.0
Integrins in angiogenesis	17.0	1453.0	84.0	-0.138	0.055	1000.0	-1000.0	-0.047	-1000.0
IL27-mediated signaling events	17.0	889.0	51.0	-0.104	0.044	1000.0	-1000.0	-0.044	-1000.0
Signaling events mediated by PTP1B	16.0	1264.0	76.0	-0.186	0.039	1000.0	-1000.0	-0.03	-1000.0
amb2 Integrin signaling	16.0	1355.0	82.0	-0.185	0.036	1000.0	-1000.0	-0.035	-1000.0
Insulin Pathway	16.0	1238.0	74.0	-0.056	0.066	1000.0	-1000.0	-0.046	-1000.0
JNK signaling in the CD4+ TCR pathway	15.0	258.0	17.0	-0.083	0.028	1000.0	-1000.0	-0.034	-1000.0
mTOR signaling pathway	15.0	804.0	53.0	-0.044	0.03	1000.0	-1000.0	-0.037	-1000.0
LPA4-mediated signaling events	14.0	176.0	12.0	-0.053	0.004	1000.0	-1000.0	-0.019	-1000.0
Regulation of nuclear SMAD2/3 signaling	14.0	1948.0	136.0	-0.261	0.052	1000.0	-1000.0	-0.036	-1000.0
Visual signal transduction: Cones	14.0	546.0	38.0	-0.043	0.043	1000.0	-1000.0	-0.013	-1000.0
p75(NTR)-mediated signaling	14.0	1801.0	125.0	-0.277	0.07	1000.0	-1000.0	-0.066	-1000.0
Caspase cascade in apoptosis	13.0	984.0	74.0	-0.056	0.045	1000.0	-1000.0	-0.034	-1000.0
Nectin adhesion pathway	13.0	867.0	63.0	-0.102	0.073	1000.0	-1000.0	-0.042	-1000.0
Signaling events mediated by HDAC Class III	13.0	549.0	40.0	-0.279	0.046	1000.0	-1000.0	-0.019	-1000.0
IL1-mediated signaling events	13.0	865.0	62.0	-0.083	0.061	1000.0	-1000.0	-0.047	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	13.0	598.0	45.0	-0.056	0.076	1000.0	-1000.0	-0.042	-1000.0
Rapid glucocorticoid signaling	13.0	266.0	20.0	-0.061	0.034	1000.0	-1000.0	-0.006	-1000.0
Cellular roles of Anthrax toxin	12.0	475.0	39.0	-0.056	0.027	1000.0	-1000.0	-0.023	-1000.0
Presenilin action in Notch and Wnt signaling	12.0	777.0	61.0	-0.148	0.07	1000.0	-1000.0	-0.047	-1000.0
IL2 signaling events mediated by PI3K	12.0	733.0	58.0	-0.058	0.048	1000.0	-1000.0	-0.034	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	12.0	1550.0	120.0	-0.239	0.074	1000.0	-1000.0	-0.047	-1000.0
FOXM1 transcription factor network	12.0	656.0	51.0	-0.211	0.053	1000.0	-1000.0	-0.071	-1000.0
ErbB4 signaling events	11.0	813.0	69.0	-0.05	0.037	1000.0	-1000.0	-0.044	-1000.0
Syndecan-3-mediated signaling events	11.0	396.0	35.0	-0.116	0.07	1000.0	-1000.0	-0.029	-1000.0
Visual signal transduction: Rods	11.0	588.0	52.0	-0.067	0.048	1000.0	-1000.0	-0.027	-1000.0
BARD1 signaling events	10.0	591.0	57.0	-0.04	0.05	1000.0	-1000.0	-0.037	-1000.0
Sphingosine 1-phosphate (S1P) pathway	10.0	297.0	28.0	-0.133	0.056	1000.0	-1000.0	-0.022	-1000.0
Syndecan-2-mediated signaling events	10.0	731.0	69.0	-0.155	0.05	1000.0	-1000.0	-0.025	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	10.0	743.0	74.0	-0.126	0.067	1000.0	-1000.0	-0.065	-1000.0
S1P3 pathway	10.0	425.0	42.0	-0.133	0.048	1000.0	-1000.0	-0.033	-1000.0
S1P1 pathway	9.0	351.0	36.0	-0.054	0.027	1000.0	-1000.0	-0.043	-1000.0
Retinoic acid receptors-mediated signaling	9.0	537.0	58.0	-0.037	0.053	1000.0	-1000.0	-0.033	-1000.0
TCGA08_rtk_signaling	9.0	259.0	26.0	-0.182	0.045	1000.0	-1000.0	-0.006	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	8.0	695.0	83.0	-0.172	0.048	1000.0	-1000.0	-0.033	-1000.0
TCGA08_p53	8.0	61.0	7.0	-0.022	0.025	1000.0	-1000.0	-0.012	-1000.0
Class I PI3K signaling events	8.0	600.0	73.0	-0.186	0.05	1000.0	-1000.0	-0.038	-1000.0
Regulation of Telomerase	8.0	865.0	102.0	-0.187	0.071	1000.0	-1000.0	-0.03	-1000.0
Signaling events mediated by HDAC Class I	7.0	735.0	104.0	-0.056	0.062	1000.0	-1000.0	-0.03	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	7.0	251.0	33.0	-0.112	0.055	1000.0	-1000.0	-0.033	-1000.0
Class IB PI3K non-lipid kinase events	7.0	21.0	3.0	-0.015	0.015	1000.0	-1000.0	-0.003	-1000.0
a4b1 and a4b7 Integrin signaling	6.0	33.0	5.0	0.004	0.034	1000.0	-1000.0	0.003	-1000.0
PLK1 signaling events	6.0	583.0	85.0	-0.006	0.049	1000.0	-1000.0	-0.032	-1000.0
IL2 signaling events mediated by STAT5	6.0	134.0	22.0	-0.033	0.033	1000.0	-1000.0	-0.046	-1000.0
Effects of Botulinum toxin	5.0	130.0	26.0	-0.064	0.048	1000.0	-1000.0	-0.01	-1000.0
PDGFR-beta signaling pathway	5.0	490.0	97.0	-0.143	0.079	1000.0	-1000.0	-0.057	-1000.0
Signaling events mediated by PRL	5.0	175.0	34.0	-0.086	0.04	1000.0	-1000.0	-0.043	-1000.0
S1P4 pathway	5.0	135.0	25.0	-0.003	0.047	1000.0	-1000.0	-0.029	-1000.0
Aurora B signaling	5.0	393.0	67.0	-0.323	0.104	1000.0	-1000.0	-0.04	-1000.0
Insulin-mediated glucose transport	4.0	151.0	32.0	-0.08	0.05	1000.0	-1000.0	-0.031	-1000.0
Class I PI3K signaling events mediated by Akt	4.0	298.0	68.0	-0.08	0.05	1000.0	-1000.0	-0.034	-1000.0
S1P5 pathway	4.0	84.0	17.0	-0.007	0.032	1000.0	-1000.0	-0.018	-1000.0
Signaling mediated by p38-gamma and p38-delta	4.0	65.0	15.0	-0.002	0.027	1000.0	-1000.0	-0.027	-1000.0
Atypical NF-kappaB pathway	4.0	126.0	31.0	-0.018	0.04	1000.0	-1000.0	-0.025	-1000.0
Canonical Wnt signaling pathway	4.0	223.0	51.0	-0.034	0.065	1000.0	-1000.0	-0.049	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	4.0	616.0	125.0	-0.01	0.07	1000.0	-1000.0	-0.048	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	3.0	72.0	23.0	-0.016	0.049	1000.0	-1000.0	-0.027	-1000.0
Canonical NF-kappaB pathway	3.0	151.0	39.0	-0.056	0.061	1000.0	-1000.0	-0.033	-1000.0
Circadian rhythm pathway	3.0	83.0	22.0	-0.017	0.041	1000.0	-1000.0	-0.027	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	3.0	138.0	37.0	0.0	0.063	1000.0	-1000.0	-0.031	-1000.0
HIF-2-alpha transcription factor network	3.0	165.0	43.0	-0.159	0.162	1000.0	-1000.0	-0.042	-1000.0
FoxO family signaling	3.0	249.0	64.0	-0.08	0.102	1000.0	-1000.0	-0.04	-1000.0
TCGA08_retinoblastoma	3.0	31.0	8.0	-0.031	0.031	1000.0	-1000.0	-0.003	-1000.0
E-cadherin signaling in keratinocytes	3.0	131.0	43.0	-0.029	0.051	1000.0	-1000.0	-0.038	-1000.0
p38 MAPK signaling pathway	3.0	165.0	44.0	-0.031	0.049	1000.0	-1000.0	-0.022	-1000.0
Aurora A signaling	2.0	125.0	60.0	-0.023	0.055	1000.0	-1000.0	-0.022	-1000.0
EPO signaling pathway	2.0	162.0	55.0	-0.013	0.059	1000.0	-1000.0	-0.04	-1000.0
TRAIL signaling pathway	2.0	107.0	48.0	-0.012	0.074	1000.0	-1000.0	-0.038	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	99.0	36.0	-0.053	0.055	1000.0	-1000.0	-0.034	-1000.0
Signaling events mediated by HDAC Class II	1.0	91.0	75.0	-0.036	0.074	1000.0	-1000.0	-0.025	-1000.0
E-cadherin signaling in the nascent adherens junction	1.0	143.0	76.0	-0.054	0.066	1000.0	-1000.0	-0.06	-1000.0
Arf6 trafficking events	1.0	103.0	71.0	-0.048	0.05	1000.0	-1000.0	-0.028	-1000.0
PLK2 and PLK4 events	0.0	0.0	3.0	0.016	0.027	1000.0	-1000.0	-0.017	-1000.0
Arf6 downstream pathway	0.0	9.0	43.0	-0.055	0.046	1000.0	-1000.0	-0.025	-1000.0
Aurora C signaling	0.0	4.0	7.0	-0.005	0.046	1000.0	-1000.0	-0.012	-1000.0
Glypican 2 network	0.0	3.0	4.0	-0.018	0.017	1000.0	-1000.0	-0.001	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	12.0	27.0	-0.0	0.066	1000.0	-1000.0	-0.035	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.026	0.051	1000.0	-1000.0	0.003	-1000.0
Arf1 pathway	0.0	25.0	54.0	-0.001	0.052	1000.0	-1000.0	-0.021	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.072	1000.0	-1000.0	-0.006	-1000.0
Total	3473	200861	7203	-22.1320471339	8.03772207783	131000	-131000	-4.7090599522	-131000