rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(4), EIF4A1(5), EIF4A2(9), EIF4E(2), EIF4G1(15), EIF4G2(7), EIF4G3(24), GHR(8), IRS1(13), MAPK1(2), MAPK14(4), MAPK3(3), MKNK1(3), PABPC1(10), PDK2(5), PDPK1(3), PIK3CA(172), PIK3R1(100), PRKCA(10), PTEN(228), RPS6KB1(5) 10144798 632 216 417 49 92 134 132 39 191 44 <1.00e-15 <1.00e-15 <4.76e-14 2 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(4), AKT2(6), AKT3(11), BPNT1(3), GRB2(3), ILK(5), MAPK1(2), MAPK3(3), PDK1(2), PIK3CA(172), PIK3CD(12), PTEN(228), PTK2B(16), RBL2(19), SHC1(7), SOS1(13) 7243620 506 208 307 39 92 126 107 36 117 28 <1.00e-15 <1.00e-15 <4.76e-14 3 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 25 AKT1(4), AKT2(6), AKT3(11), BAD(2), GRB2(3), GSK3A(10), GSK3B(13), IL4R(6), IRS1(13), JAK1(20), JAK3(10), MAP4K1(11), MAPK1(2), MAPK3(3), PDK1(2), PIK3CA(172), PIK3CD(12), PIK3R1(100), PPP1R13B(9), RAF1(8), SHC1(7), SOS1(13), SOS2(17), STAT6(10) 12574116 464 202 337 55 106 123 119 5 95 16 9.87e-11 <1.00e-15 <4.76e-14 4 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(4), CREB1(6), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K6(10), MAP3K1(30), MAPK1(2), MAPK14(4), MAPK3(3), NFKB1(10), PIK3CA(172), PIK3R1(100), RB1(26), RELA(6), SP1(7) 7166136 394 200 272 31 63 112 107 4 89 19 2.19e-12 <1.00e-15 <4.76e-14 5 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(32), EP300(32), FYN(7), IL2RG(13), IL7(1), IL7R(12), JAK1(20), JAK3(10), LCK(5), NMI(3), PIK3CA(172), PIK3R1(100), PTK2B(16), STAT5A(5), STAT5B(7) 10213532 435 200 312 56 77 121 115 6 100 16 3.60e-08 <1.00e-15 <4.76e-14 6 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(21), ARHGEF1(12), F2(8), F2R(6), GNA12(8), GNA13(7), GNAI1(5), GNAQ(3), GNB1(2), GNGT1(1), MAP3K7(9), PIK3CA(172), PIK3R1(100), PLCB1(5), PPP1R12B(20), PRKCA(10), PTK2B(16), ROCK1(22) 9289594 427 199 304 63 96 111 112 7 84 17 2.95e-06 <1.00e-15 <4.76e-14 7 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(4), BAD(2), CHRNB1(2), CHRNG(4), MUSK(15), PIK3CA(172), PIK3R1(100), PTK2(12), PTK2B(16), RAPSN(2), SRC(3), TERT(4), YWHAH(3) 5901003 339 197 220 43 57 93 94 4 76 15 2.46e-06 <1.00e-15 <4.76e-14 8 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(4), BAD(2), BCL2L1(4), CASP9(3), CDC42(4), CHUK(8), ELK1(3), H2AFX(1), HRAS(1), MAP2K1(2), MAPK3(3), NFKB1(10), PIK3CA(172), PIK3R1(100), RAC1(1), RAF1(8), RALA(6), RALBP1(6), RALGDS(9), RELA(6), RHOA(3) 6942603 356 197 235 28 56 106 95 4 78 17 4.18e-12 <1.00e-15 <4.76e-14 9 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(3), HLA-A(1), IL18(2), ITGB1(8), KLRC1(7), KLRC2(3), KLRC3(1), KLRC4(5), KLRD1(3), MAP2K1(2), MAPK3(3), PAK1(3), PIK3CA(172), PIK3R1(100), PTK2B(16), PTPN6(6), RAC1(1), SYK(4), VAV1(12) 6852023 352 196 232 34 59 99 93 5 81 15 2.61e-09 <1.00e-15 <4.76e-14 10 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(3), CD3D(6), CD3E(2), CD3G(3), CD80(5), CD86(5), CTLA4(2), GRB2(3), HLA-DRA(1), ICOS(3), IL2(2), ITK(7), LCK(5), PIK3CA(172), PIK3R1(100), PTPN11(8) 4602586 327 194 208 19 48 91 88 5 80 15 1.67e-12 <1.00e-15 <4.76e-14 11 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(4), PIK3CA(172), PIK3R1(100), PLCB1(5), PLCG1(12), PRKCA(10), VAV1(12) 4719996 315 194 195 39 51 75 91 7 76 15 8.56e-05 <1.00e-15 <4.76e-14 12 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(4), AKT2(6), AKT3(11), CDKN1A(1), ELK1(3), GRB2(3), HRAS(1), MAP2K1(2), MAP2K2(5), NGFR(3), NTRK1(13), PIK3CA(172), PIK3CD(12), SHC1(7), SOS1(13) 5624797 256 151 155 33 59 99 82 3 13 0 7.82e-08 <1.00e-15 <4.76e-14 13 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(9), ELK1(3), FOS(3), GRB2(3), HRAS(1), INS(3), INSR(18), IRS1(13), JUN(1), MAP2K1(2), MAPK3(3), MAPK8(10), PIK3CA(172), PIK3R1(100), PTPN11(8), RAF1(8), RASA1(30), SHC1(7), SLC2A4(9), SOS1(13), SRF(3) 9128952 419 202 292 39 82 118 108 5 90 16 3.73e-13 1.11e-15 4.76e-14 14 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(21), AKT1(4), ASAH1(7), GNAI1(5), GNB1(2), GNGT1(1), ITGAV(10), ITGB3(11), MAPK1(2), MAPK3(3), PDGFA(3), PDGFRA(24), PIK3CA(172), PIK3R1(100), PLCB1(5), PRKCA(10), PTK2(12), RAC1(1), SMPD1(11), SMPD2(7), SPHK1(2), SRC(3) 9845923 416 201 295 65 72 117 114 6 90 17 1.52e-05 1.22e-15 4.76e-14 15 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(4), EIF4A1(5), EIF4A2(9), EIF4B(7), EIF4E(2), EIF4G1(15), EIF4G2(7), EIF4G3(24), FKBP1A(1), MKNK1(3), PDK2(5), PDPK1(3), PIK3CA(172), PIK3R1(100), PPP2CA(6), PTEN(228), RPS6(7), RPS6KB1(5), TSC1(12), TSC2(15) 9925342 630 218 416 44 91 141 126 38 190 44 <1.00e-15 1.33e-15 4.76e-14 16 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(21), AKT1(4), BAD(2), BAX(3), BCL2L1(4), CSF2RB(14), IGF1(5), IGF1R(13), IL3(2), IL3RA(9), KIT(24), KITLG(3), PIK3CA(172), PIK3R1(100), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), YWHAH(3) 7856210 406 200 286 52 74 120 107 6 83 16 3.11e-09 1.33e-15 4.76e-14 17 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(8), CRK(2), CXCL12(6), CXCR4(1), GNAI1(5), GNAQ(3), GNB1(2), GNGT1(1), HRAS(1), MAP2K1(2), MAPK1(2), MAPK3(3), NFKB1(10), PIK3C2G(16), PIK3CA(172), PIK3R1(100), PLCG1(12), PRKCA(10), PTK2(12), PTK2B(16), PXN(6), RAF1(8), RELA(6) 10130836 404 196 282 58 82 109 108 4 86 15 2.26e-06 1.44e-15 4.76e-14 18 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(4), BCR(6), CRKL(6), FOS(3), GRB2(3), HRAS(1), JAK2(17), JUN(1), MAP2K1(2), MAP2K4(9), MAP3K1(30), MAPK3(3), MAPK8(10), MYC(8), PIK3CA(172), PIK3R1(100), RAF1(8), SOS1(13), STAT1(15), STAT5A(5), STAT5B(7) 9960926 423 199 298 39 75 122 113 4 90 19 1.16e-12 1.55e-15 4.76e-14 19 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(4), CREB1(6), GRB2(3), HRAS(1), MAPK1(2), MAPK3(3), MAPK7(14), MEF2A(3), MEF2B(1), MEF2C(11), MEF2D(7), NTRK1(13), PIK3CA(172), PIK3R1(100), PLCG1(12), RPS6KA1(1), SHC1(7) 7017966 360 199 240 36 64 100 96 6 79 15 9.15e-10 1.67e-15 4.76e-14 20 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(4), DPM2(2), GRB2(3), HRAS(1), KLK2(2), NTRK1(13), PIK3CA(172), PIK3R1(100), PLCG1(12), PRKCA(10), SHC1(7), SOS1(13) 5625851 339 197 216 32 54 97 95 4 74 15 1.34e-08 1.67e-15 4.76e-14 21 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 AKT1(4), CAT(4), GH1(3), GHR(8), HRAS(1), IGF1(5), IGF1R(13), PIK3CA(172), PIK3R1(100), SHC1(7), SOD1(2), SOD2(3) 4715937 322 195 203 28 53 83 91 5 75 15 1.75e-09 1.67e-15 4.76e-14 22 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(4), BCAR1(8), CDKN1B(7), GRB2(3), ILK(5), ITGB1(8), MAPK1(2), MAPK3(3), PDK2(5), PDPK1(3), PIK3CA(172), PIK3R1(100), PTEN(228), PTK2(12), SHC1(7), SOS1(13) 6867110 580 213 364 30 73 121 124 37 183 42 <1.00e-15 1.78e-15 4.76e-14 23 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(3), ARF3(4), CCND1(14), CDK2(2), CDK4(3), CDKN1A(1), CDKN1B(7), CDKN2A(2), CFL1(1), E2F1(9), E2F2(3), MDM2(4), PRB1(2), TP53(74) 2834146 129 98 103 21 35 37 31 1 25 0 0.00250 1.78e-15 4.76e-14 24 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(7), AKT1(4), ANXA1(5), CALM1(2), CALM2(4), GNAS(24), GNB1(2), GNGT1(1), NFKB1(10), NOS3(11), NPPA(2), NR3C1(18), PIK3CA(172), PIK3R1(100), RELA(6), SYT1(4) 6288912 372 197 249 26 79 99 91 4 84 15 9.69e-14 2.11e-15 5.32e-14 25 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(8), CDKN2A(2), E2F1(9), MDM2(4), MYC(8), PIK3CA(172), PIK3R1(100), POLR1A(16), POLR1B(16), POLR1C(2), POLR1D(3), RAC1(1), RB1(26), TBX2(2), TP53(74), TWIST1(1) 7080267 444 223 300 50 87 115 119 6 99 18 4.87e-10 2.22e-15 5.32e-14 26 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(21), AKT1(4), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CREB1(6), GNAS(24), GRB2(3), HRAS(1), MAPK1(2), MAPK14(4), MAPK3(3), PIK3CA(172), PIK3R1(100), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(10), RAC1(1), RPS6KA1(1), RPS6KA5(11), SOS1(13) 10330216 425 200 300 54 88 113 111 5 92 16 4.56e-08 2.33e-15 5.32e-14 27 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(6), ACTR3(1), ARPC1A(6), ARPC1B(5), ARPC2(1), ARPC3(1), ARPC4(1), CDC42(4), PAK1(3), PDGFRA(24), PIK3CA(172), PIK3R1(100), RAC1(1), WASL(8) 4979142 333 195 213 16 51 90 92 4 80 16 8.99e-15 2.33e-15 5.32e-14 28 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 33 DUSP1(2), GORASP1(10), IKBKG(4), MAP2K4(9), MAP2K7(4), MAPK1(2), MAPK10(9), MAPK11(3), MAPK12(3), MAPK13(4), MAPK14(4), MAPK3(3), MAPK8(10), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(9), MAPK9(5), MAPKAPK5(5), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NFKBIL1(2), PIK3CA(172), PIK3CD(12), PIK3R1(100), SYT1(4), TRAF2(3), TRAF3(5), TRAF5(7), TRAF6(7) 11364262 432 197 312 59 93 116 105 4 98 16 1.57e-08 2.44e-15 5.32e-14 29 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 28 AKT1(4), CABIN1(19), CALM1(2), CALM2(4), CAMK1(2), CAMK1G(5), HDAC5(12), IGF1(5), IGF1R(13), INS(3), INSR(18), MAP2K6(10), MAPK14(4), MAPK7(14), MEF2A(3), MEF2B(1), MEF2C(11), MEF2D(7), NFATC1(10), NFATC2(13), PIK3CA(172), PIK3R1(100), PPP3CA(4), PPP3CB(5), PPP3CC(6), SYT1(4), YWHAH(3) 12178275 454 202 331 71 109 116 116 8 90 15 1.36e-07 2.55e-15 5.32e-14 30 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(5), CRK(2), CRKL(6), DOCK1(22), ELK1(3), FOS(3), GAB1(8), GRB2(3), HGF(14), HRAS(1), ITGA1(17), ITGB1(8), JUN(1), MAP2K1(2), MAP2K2(5), MAP4K1(11), MAPK1(2), MAPK3(3), MAPK8(10), MET(17), PAK1(3), PIK3CA(172), PIK3R1(100), PTEN(228), PTK2(12), PTK2B(16), PTPN11(8), PXN(6), RAF1(8), RAP1A(4), RAP1B(2), RASA1(30), SOS1(13), SRC(3), STAT3(10) 16563754 758 217 537 93 133 188 148 37 208 44 1.05e-14 2.78e-15 5.32e-14 31 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 33 AKT1(4), BAD(2), BCL2L1(4), CBL(12), CFLAR(6), CRKL(6), E2F1(9), FOS(3), GRB2(3), HRAS(1), IL2RA(4), IL2RB(3), IL2RG(13), IRS1(13), JAK1(20), JAK3(10), MAPK1(2), MAPK3(3), MYC(8), NMI(3), PIK3CA(172), PIK3R1(100), PPIA(1), PTPN6(6), RAF1(8), RPS6KB1(5), SHC1(7), SOS1(13), STAT5A(5), STAT5B(7), SYK(4) 12777577 457 203 334 55 84 140 122 5 91 15 1.98e-10 2.89e-15 5.32e-14 32 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(21), DIAPH1(12), FYN(7), GSN(5), HRAS(1), ITGA1(17), ITGB1(8), MAP2K1(2), MAPK1(2), MAPK3(3), MYL2(2), MYLK(14), PFN1(1), PIK3CA(172), PIK3R1(100), PTK2(12), PXN(6), RAF1(8), ROCK1(22), SHC1(7), SRC(3), TLN1(23) 13836087 448 199 328 53 93 128 116 4 90 17 7.62e-10 3.00e-15 5.32e-14 33 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(3), AKT1(4), AKT2(6), AKT3(11), BAD(2), BTK(12), CDKN2A(2), DAPP1(9), GRB2(3), GSK3A(10), GSK3B(13), IARS(8), IGFBP1(4), INPP5D(9), PDK1(2), PIK3CA(172), PPP1R13B(9), PTEN(228), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), RPS6KB1(5), SHC1(7), SOS1(13), SOS2(17), TEC(8), YWHAE(4), YWHAG(3), YWHAH(3), YWHAQ(1), YWHAZ(1) 13065934 603 211 404 65 113 161 131 37 133 28 1.89e-15 3.11e-15 5.32e-14 34 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(4), APC(56), AXIN1(9), CCND1(14), CD14(2), CTNNB1(80), DVL1(3), FZD1(3), GJA1(5), GNAI1(5), GSK3B(13), IRAK1(4), LBP(3), LEF1(9), LY96(4), MYD88(3), NFKB1(10), PDPK1(3), PIK3CA(172), PIK3R1(100), PPP2CA(6), RELA(6), TIRAP(2), TLR4(17), TOLLIP(1), WNT1(1) 10634125 535 210 355 58 77 201 122 6 109 20 2.06e-13 3.11e-15 5.32e-14 35 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(12), CALM1(2), CALM2(4), ELK1(3), FCER1A(9), FCER1G(2), FOS(3), GRB2(3), HRAS(1), JUN(1), LYN(9), MAP2K1(2), MAP2K4(9), MAP2K7(4), MAP3K1(30), MAPK1(2), MAPK3(3), MAPK8(10), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(5), PAK2(3), PIK3CA(172), PIK3R1(100), PLA2G4A(13), PLCG1(12), PPP3CA(4), PPP3CB(5), PPP3CC(6), RAF1(8), SHC1(7), SOS1(13), SYK(4), SYT1(4), VAV1(12) 15285000 512 199 385 78 103 160 124 6 103 16 2.19e-07 3.11e-15 5.32e-14 36 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(9), DPM2(2), ELK1(3), FOS(3), GRB2(3), HRAS(1), JUN(1), KLK2(2), MAP2K1(2), MAPK3(3), MAPK8(10), NGFR(3), PIK3CA(172), PIK3R1(100), PLCG1(12), RAF1(8), SHC1(7), SOS1(13) 6810755 354 194 228 24 58 100 101 4 76 15 3.42e-13 3.11e-15 5.32e-14 37 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(4), BAD(2), CASP9(3), CHUK(8), GH1(3), GHR(8), NFKB1(10), NFKBIA(3), PDPK1(3), PIK3CA(172), PIK3R1(100), PPP2CA(6), RELA(6), YWHAH(3) 5135005 331 199 212 19 49 93 92 4 78 15 4.49e-13 3.22e-15 5.36e-14 38 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(4), EIF2B5(5), EIF2S1(2), EIF2S2(9), EIF2S3(6), EIF4E(2), GSK3B(13), IGF1(5), IGF1R(13), INPPL1(17), PDK2(5), PDPK1(3), PIK3CA(172), PIK3R1(100), PPP2CA(6), PTEN(228), RPS6(7), RPS6KB1(5) 7138255 602 217 386 46 80 131 116 40 193 42 <1.00e-15 3.33e-15 5.37e-14 39 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 24 GH1(3), GHR(8), GRB2(3), HRAS(1), INS(3), INSR(18), IRS1(13), JAK2(17), MAP2K1(2), MAPK1(2), MAPK3(3), PIK3CA(172), PIK3R1(100), PLCG1(12), PRKCA(10), PTPN6(6), RAF1(8), RPS6KA1(1), SHC1(7), SLC2A4(9), SOS1(13), SRF(3), STAT5A(5), STAT5B(7) 11855606 426 197 302 59 93 114 115 5 81 18 2.38e-07 3.44e-15 5.37e-14 40 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(4), CCND1(14), CCNE1(6), CDK2(2), CDK4(3), CDK6(3), CDKN1A(1), CDKN1B(7), E2F1(9), HRAS(1), MAPK1(2), MAPK3(3), NFKB1(10), NFKBIA(3), PAK1(3), PIK3CA(172), PIK3R1(100), RAC1(1), RAF1(8), RB1(26), RELA(6), TFDP1(13) 7293532 397 202 273 38 67 107 108 4 93 18 6.76e-11 3.55e-15 5.37e-14 41 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM1(2), CALM2(4), CD3D(6), CD3E(2), CD3G(3), ELK1(3), FOS(3), FYN(7), GRB2(3), HRAS(1), JUN(1), LCK(5), MAP2K1(2), MAP2K4(9), MAP3K1(30), MAPK3(3), MAPK8(10), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(5), NFKB1(10), NFKBIA(3), PIK3CA(172), PIK3R1(100), PLCG1(12), PPP3CA(4), PPP3CB(5), PPP3CC(6), PRKCA(10), PTPN7(6), RAC1(1), RAF1(8), RASA1(30), RELA(6), SHC1(7), SOS1(13), SYT1(4), VAV1(12), ZAP70(8) 17112318 551 202 422 83 118 163 129 5 119 17 1.22e-08 3.66e-15 5.37e-14 42 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(4), BAD(2), GRB2(3), HRAS(1), IGF1R(13), IRS1(13), MAP2K1(2), MAPK1(2), MAPK3(3), PIK3CA(172), PIK3R1(100), RAF1(8), SHC1(7), SOS1(13), YWHAH(3) 6731221 346 196 223 34 62 91 97 5 76 15 3.85e-09 3.66e-15 5.37e-14 43 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(9), FOS(3), GRB2(3), HRAS(1), JAK2(17), JUN(1), MAP2K1(2), MAPK3(3), MPL(7), PIK3CA(172), PIK3R1(100), PLCG1(12), PRKCA(10), RAF1(8), RASA1(30), SHC1(7), SOS1(13), STAT1(15), STAT3(10), STAT5A(5), STAT5B(7), THPO(7) 10932923 442 196 313 50 83 126 118 4 92 19 2.33e-09 4.00e-15 5.73e-14 44 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(9), ELK1(3), FOS(3), GRB2(3), HRAS(1), JAK1(20), JUN(1), MAP2K1(2), MAP2K4(9), MAP3K1(30), MAPK3(3), MAPK8(10), PDGFA(3), PDGFRA(24), PIK3CA(172), PIK3R1(100), PLCG1(12), PRKCA(10), RAF1(8), RASA1(30), SHC1(7), SOS1(13), SRF(3), STAT1(15), STAT3(10), STAT5A(5) 12730148 506 201 375 56 94 144 134 4 112 18 5.97e-12 4.44e-15 6.08e-14 45 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(54), ATR(38), CDC25C(5), CHEK1(2), CHEK2(14), TP53(74), YWHAH(3) 5921097 190 103 162 19 41 59 41 1 44 4 7.38e-05 4.44e-15 6.08e-14 46 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(5), MAX(12), MYC(8), SP1(7), SP3(10), TP53(74), WT1(3) 2507279 119 91 90 10 35 32 28 2 22 0 1.69e-06 4.55e-15 6.10e-14 47 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(5), AGT(8), AKT1(4), CALM1(2), CALM2(4), CALR(3), CAMK1(2), CAMK1G(5), CAMK4(5), CREBBP(32), CSNK1A1(4), EDN1(4), ELSPBP1(5), F2(8), FKBP1A(1), GATA4(3), GSK3B(13), HAND1(6), HRAS(1), IGF1(5), LIF(3), MAP2K1(2), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(10), MEF2C(11), MYH2(43), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(5), NKX2-5(2), NPPA(2), PIK3CA(172), PIK3R1(100), PPP3CA(4), PPP3CB(5), PPP3CC(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), RAF1(8), RPS6KB1(5), SYT1(4) 18041266 573 207 444 97 126 176 137 5 111 18 4.11e-08 5.00e-15 6.41e-14 48 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(5), EIF1(1), EIF2B2(5), EIF2B3(7), EIF2B4(4), EIF2B5(5), EIF2S1(2), EIF2S2(9), EIF2S3(6), ELAVL1(8), FLT1(20), FLT4(9), HIF1A(16), HRAS(1), KDR(26), NOS3(11), PIK3CA(172), PIK3R1(100), PLCG1(12), PRKCA(10), PTK2(12), PXN(6), SHC1(7), VHL(3) 12174092 457 197 334 59 94 128 110 7 103 15 3.73e-09 5.00e-15 6.41e-14 49 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 48 AKT1(4), AKT2(6), AKT3(11), BRD4(10), CAP1(7), CBL(12), CDC42(4), CDKN2A(2), F2RL2(2), FLOT1(1), FLOT2(2), GRB2(3), GSK3A(10), GSK3B(13), IGFBP1(4), INPPL1(17), IRS1(13), IRS4(20), LNPEP(10), MAPK1(2), MAPK3(3), PARD3(19), PDK1(2), PIK3CA(172), PIK3CD(12), PIK3R1(100), PPYR1(8), PTEN(228), PTPN1(5), RAF1(8), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), RPS6KB1(5), SERPINB6(3), SHC1(7), SLC2A4(9), SORBS1(18), SOS1(13), SOS2(17), YWHAE(4), YWHAG(3), YWHAH(3), YWHAQ(1), YWHAZ(1) 20615343 828 217 603 121 160 197 173 40 214 44 1.21e-11 5.66e-15 6.98e-14 50 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(1), CDK5(2), CDK5R1(3), CFL1(1), CHN1(3), LIMK1(8), MAP3K1(30), MYL2(2), MYLK(14), NCF2(8), PAK1(3), PDGFRA(24), PIK3CA(172), PIK3R1(100), PLD1(14), PPP1R12B(20), RAC1(1), RALBP1(6), RPS6KB1(5), TRIO(34), VAV1(12), WASF1(3) 12890193 466 200 341 66 88 134 115 6 104 19 1.52e-07 5.66e-15 6.98e-14 51 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(8), DNAJC3(9), EIF2S1(2), EIF2S2(9), MAP3K14(6), NFKB1(10), NFKBIA(3), RELA(6), TP53(74) 3670290 127 84 100 10 32 39 26 3 27 0 2.41e-06 6.22e-15 7.50e-14 52 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(9), ELK1(3), FOS(3), GRB2(3), HRAS(1), IGF1(5), IGF1R(13), IRS1(13), JUN(1), MAP2K1(2), MAPK3(3), MAPK8(10), PIK3CA(172), PIK3R1(100), PTPN11(8), RAF1(8), RASA1(30), SHC1(7), SOS1(13), SRF(3) 8874392 407 200 280 36 72 117 108 5 89 16 5.21e-13 6.33e-15 7.50e-14 53 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(9), EGF(19), EGFR(12), ELK1(3), FOS(3), GRB2(3), HRAS(1), JAK1(20), JUN(1), MAP2K1(2), MAP2K4(9), MAP3K1(30), MAPK3(3), MAPK8(10), PIK3CA(172), PIK3R1(100), PLCG1(12), PRKCA(10), RAF1(8), RASA1(30), SHC1(7), SOS1(13), SRF(3), STAT1(15), STAT3(10), STAT5A(5) 13675029 510 199 379 61 98 144 131 4 116 17 1.01e-10 7.99e-15 9.29e-14 54 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(4), AKT2(6), AKT3(11), BCR(6), BTK(12), CD19(4), CDKN2A(2), DAPP1(9), FLOT1(1), FLOT2(2), GAB1(8), ITPR1(34), ITPR2(35), ITPR3(21), LYN(9), NR0B2(2), PDK1(2), PHF11(5), PIK3CA(172), PITX2(12), PLCG2(27), PPP1R13B(9), PREX1(25), PTEN(228), PTPRC(17), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), RPS6KB1(5), SAG(10), SYK(4), TEC(8), VAV1(12) 20146159 736 212 539 128 146 231 144 38 148 29 1.14e-09 3.10e-14 3.53e-13 55 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 49 ACOX1(7), APOA1(3), APOA2(2), CD36(8), CPT1B(6), CREBBP(32), DUSP1(2), EHHADH(11), EP300(32), FABP1(4), HSD17B4(13), INS(3), JUN(1), LPL(16), MAPK1(2), MAPK3(3), ME1(12), MRPL11(1), MYC(8), NCOA1(19), NCOR1(23), NCOR2(23), NFKBIA(3), NR0B2(2), NR1H3(4), NR2F1(7), NRIP1(17), PDGFA(3), PIK3CA(172), PIK3R1(100), PPARA(1), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(10), PTGS2(9), RB1(26), RELA(6), RXRA(3), SP1(7), SRA1(1), STAT5A(5), STAT5B(7) 22410854 641 204 514 102 136 194 160 8 122 21 7.32e-10 1.19e-12 1.33e-11 56 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(54), CDC25A(8), CDC25B(3), CDC25C(5), CDK2(2), CDK4(3), CHEK1(2), MYT1(18), RB1(26), TP53(74), WEE1(2), YWHAH(3) 6552026 200 105 170 24 53 59 41 1 40 6 2.93e-05 3.62e-12 3.98e-11 57 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 64 APAF1(17), ATM(54), ATR(38), BAI1(10), BAX(3), BID(2), CASP3(4), CASP8(21), CASP9(3), CCNB1(8), CCNB2(5), CCNB3(33), CCND1(14), CCND2(9), CCND3(4), CCNE1(6), CCNE2(8), CCNG1(9), CCNG2(2), CD82(5), CDK2(2), CDK4(3), CDK6(3), CDKN1A(1), CDKN2A(2), CHEK1(2), CHEK2(14), CYCS(2), DDB2(6), EI24(3), FAS(9), GADD45G(1), GTSE1(2), IGF1(5), IGFBP3(4), MDM2(4), MDM4(5), PERP(3), PMAIP1(1), PPM1D(13), PTEN(228), RCHY1(5), RFWD2(4), RRM2(7), RRM2B(5), SERPINB5(1), SERPINE1(5), SESN1(5), SESN2(3), SESN3(15), SIAH1(6), STEAP3(9), THBS1(11), TNFRSF10B(5), TP53(74), TP53I3(4), TP73(6), TSC2(15), ZMAT3(11) 23077507 759 226 627 131 133 228 131 34 199 34 5.68e-08 2.18e-09 2.36e-08 58 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(4), ASAH1(7), ATF1(6), BRAF(10), CAMP(1), CREB1(6), CREB5(5), CREBBP(32), CRKL(6), DAG1(6), EGR1(6), EGR2(6), EGR3(7), EGR4(5), ELK1(3), FRS2(5), GNAQ(3), JUN(1), MAP1B(35), MAP2K4(9), MAP2K7(4), MAPK1(2), MAPK10(9), MAPK3(3), MAPK8(10), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(9), MAPK9(5), NTRK1(13), OPN1LW(6), PIK3C2G(16), PIK3CA(172), PIK3CD(12), PIK3R1(100), PTPN11(8), RPS6KA3(19), SHC1(7), SRC(3), TERF2IP(2), TH(3) 18159846 571 205 446 103 130 184 126 5 108 18 1.50e-07 1.45e-08 1.54e-07 59 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(4), AKT2(6), AKT3(11), BRAF(10), CAB39(6), DDIT4(2), EIF4B(7), FIGF(5), HIF1A(16), IGF1(5), INS(3), MAPK1(2), MAPK3(3), PDPK1(3), PGF(3), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PRKAA1(8), PRKAA2(10), RHEB(3), RICTOR(21), RPS6(7), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), RPS6KA6(19), RPS6KB1(5), RPS6KB2(4), STK11(2), TSC1(12), TSC2(15), ULK1(5), ULK2(12), ULK3(5), VEGFA(2), VEGFB(2), VEGFC(6) 18585019 608 207 478 97 139 179 150 5 120 15 4.41e-08 1.02e-07 1.06e-06 60 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(6), ACTR3(1), AKT1(4), AKT2(6), AKT3(11), ANGPTL2(6), ARHGAP1(2), ARHGAP4(11), ARHGEF11(20), BTK(12), CDC42(4), CFL1(1), CFL2(8), GDI1(4), GDI2(1), INPPL1(17), ITPR1(34), ITPR2(35), ITPR3(21), LIMK1(8), MYLK(14), MYLK2(8), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PAK7(9), PDK1(2), PIK3CA(172), PIK3CD(12), PIK3CG(23), PIK3R1(100), PITX2(12), PPP1R13B(9), PTEN(228), RACGAP1(9), RHO(4), ROCK1(22), ROCK2(17), RPS4X(1), SAG(10), WASF1(3), WASL(8) 25475732 902 219 680 158 173 270 163 38 214 44 4.47e-09 1.11e-06 1.14e-05 61 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 62 AKT1(4), AKT2(6), AKT3(11), BAD(2), BCL2L1(4), CDC42(4), CDK2(2), CDKN1B(7), CDKN2A(2), CREB1(6), CREB5(5), EBP(2), ERBB4(27), F2RL2(2), GAB1(8), GRB2(3), GSK3A(10), GSK3B(13), IGF1(5), IGFBP1(4), INPPL1(17), IRS1(13), IRS4(20), MET(17), MYC(8), NOLC1(14), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PAK7(9), PARD3(19), PDK1(2), PIK3CA(172), PIK3CD(12), PPP1R13B(9), PREX1(25), PTEN(228), PTK2(12), PTPN1(5), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), RPS6KB1(5), SHC1(7), SLC2A4(9), SOS1(13), SOS2(17), TSC1(12), TSC2(15), YWHAE(4), YWHAG(3), YWHAH(3), YWHAQ(1), YWHAZ(1) 26909150 860 216 656 148 188 253 184 41 164 30 1.85e-11 1.24e-06 1.25e-05 62 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(17), ATM(54), BAX(3), CCND1(14), CCNE1(6), CDK2(2), CDK4(3), CDKN1A(1), E2F1(9), MDM2(4), PCNA(3), RB1(26), TIMP3(7), TP53(74) 6638149 223 116 193 34 46 71 52 1 47 6 0.000421 2.84e-05 0.000282 63 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(56), AXIN1(9), BTRC(14), CCND1(14), CREBBP(32), CSNK1A1(4), CSNK1D(3), CSNK2A1(9), CTBP1(1), CTNNB1(80), DVL1(3), FZD1(3), GSK3B(13), HDAC1(5), MAP3K7(9), MYC(8), NLK(5), PPARD(3), PPP2CA(6), TLE1(13), WIF1(5), WNT1(1) 10502166 296 132 229 50 65 138 47 2 40 4 1.04e-05 2.92e-05 0.000286 64 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(32), DAXX(10), HRAS(1), PAX3(5), PML(8), RARA(2), RB1(26), SIRT1(6), SP100(20), TNFRSF1A(4), TNFRSF1B(2), TP53(74) 6641355 190 99 162 31 59 55 34 2 36 4 9.65e-05 5.86e-05 0.000564 65 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(6), CDK2(2), CUL1(13), E2F1(9), FBXW7(46), RB1(26), TFDP1(13) 3092136 115 60 97 18 45 31 17 1 17 4 0.000440 8.81e-05 0.000835 66 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(6), ACTR3(1), AKT1(4), ANGPTL2(6), DAG1(6), DGKA(10), ETFA(5), GCA(2), ITGA9(16), ITPKA(1), ITPKB(11), ITPR1(34), ITPR2(35), ITPR3(21), MAP2K1(2), MAPK1(2), MAPK3(3), NR1I3(6), PAK1(3), PDE3A(19), PDE3B(15), PI3(2), PIK3C2G(16), PIK3CA(172), PIK3CD(12), PIK3R1(100), PLDN(3), PSME1(1), RIPK3(5), RPS4X(1), SGCB(4), VASP(3) 17891218 527 204 405 103 111 164 121 6 109 16 8.45e-05 0.000656 0.00613 67 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(54), ATR(38), BRCA1(17), BRCA2(57), CHEK1(2), CHEK2(14), FANCA(15), FANCC(9), FANCD2(11), FANCE(9), FANCF(1), FANCG(10), HUS1(3), MRE11A(10), RAD1(6), RAD17(13), RAD50(18), RAD51(2), RAD9A(2), TP53(74) 16271430 365 119 333 46 75 147 72 1 64 6 2.85e-07 0.000909 0.00836 68 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(4), AKT2(6), AKT3(11), CISH(2), GRB2(3), IARS(8), IL13RA1(13), IL2RG(13), IL4(1), IL4R(6), INPP5D(9), JAK1(20), JAK2(17), JAK3(10), NR0B2(2), PI3(2), PIK3CA(172), PPP1R13B(9), RPS6KB1(5), SERPINA4(4), SHC1(7), SOS1(13), SOS2(17), SRC(3), STAT6(10), TYK2(10) 13260226 377 155 276 71 79 142 111 6 35 4 5.74e-05 0.00591 0.0535 69 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(4), APC(56), AR(12), ASAH1(7), BRAF(10), CAMP(1), CCL13(2), CCL15(1), CCL16(1), DAG1(6), EGFR(12), GNA11(2), GNA15(1), GNAI1(5), GNAQ(3), ITPKA(1), ITPKB(11), ITPR1(34), ITPR2(35), ITPR3(21), KCNJ3(9), KCNJ5(7), KCNJ9(4), MAPK1(2), MAPK10(9), MAPK14(4), PHKA2(21), PIK3CA(172), PIK3CD(12), PIK3R1(100), PITX2(12), PTX3(2), RAF1(8), SRC(3) 19350915 590 210 464 120 120 197 129 7 116 21 4.38e-05 0.0152 0.136 70 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(4), AKT2(6), AKT3(11), BAD(2), BCR(6), BLNK(4), BTK(12), CD19(4), CSK(1), DAG1(6), EPHB2(12), GRB2(3), ITPKA(1), ITPKB(11), LYN(9), MAP2K1(2), MAP2K2(5), MAPK1(2), NFAT5(16), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NFKBIL1(2), PI3(2), PIK3CA(172), PIK3CD(12), PIK3R1(100), PLCG2(27), PPP1R13B(9), RAF1(8), SERPINA4(4), SHC1(7), SOS1(13), SOS2(17), SYK(4), VAV1(12) 18448082 535 202 409 109 121 170 128 6 94 16 0.000280 0.0218 0.192 71 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 FN3K(5), IMPA1(4), IMPA2(6), INPP1(3), INPP4A(21), INPP4B(16), INPP5A(5), INPP5B(5), INPP5E(1), INPPL1(17), IPMK(4), ISYNA1(2), ITPK1(4), ITPKA(1), ITPKB(11), MINPP1(3), MIOX(6), OCRL(19), PI4KA(17), PI4KB(9), PIK3C3(14), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIP4K2A(5), PIP4K2B(7), PIP4K2C(3), PIP5K1A(8), PIP5K1B(5), PIP5K1C(5), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PLCD1(5), PLCD3(3), PLCD4(11), PLCE1(41), PLCG1(12), PLCG2(27), PLCZ1(14), PTEN(228), PTPMT1(2), SYNJ1(29), SYNJ2(11) 26523385 856 212 655 167 206 234 180 40 168 28 2.29e-08 0.0243 0.211 72 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 81 AIFM1(14), AKT1(4), AKT2(6), AKT3(11), APAF1(17), ATM(54), BAD(2), BAX(3), BCL2L1(4), BID(2), BIRC2(10), BIRC3(5), CAPN1(5), CAPN2(11), CASP10(8), CASP3(4), CASP6(7), CASP7(4), CASP8(21), CASP9(3), CFLAR(6), CHUK(8), CSF2RB(14), CYCS(2), DFFB(4), ENDOG(1), FADD(1), FAS(9), FASLG(7), IKBKB(13), IKBKG(4), IL1B(2), IL1R1(5), IL1RAP(8), IL3(2), IL3RA(9), IRAK1(4), IRAK2(9), IRAK3(10), IRAK4(7), MAP3K14(6), MYD88(3), NFKB1(10), NFKB2(9), NFKBIA(3), NTRK1(13), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PPP3CA(4), PPP3CB(5), PPP3CC(6), PPP3R1(1), PPP3R2(3), PRKACA(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), RELA(6), RIPK1(9), TNFRSF10A(2), TNFRSF10B(5), TNFRSF10C(4), TNFRSF10D(6), TNFRSF1A(4), TNFSF10(1), TP53(74), TRAF2(3) 30167075 880 230 720 163 185 298 188 7 182 20 1.44e-08 0.107 0.920 73 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(8), ATM(54), ATR(38), CCNA1(5), CCND1(14), CCNE1(6), CDC25A(8), CDK2(2), CDK4(3), CDK6(3), CDKN1A(1), CDKN1B(7), CDKN2A(2), DHFR(5), E2F1(9), GSK3B(13), HDAC1(5), RB1(26), SKP2(7), TFDP1(13), TGFB1(2), TGFB2(5), TGFB3(9), TP53(74) 10840158 319 132 287 65 82 99 61 1 69 7 0.00408 0.185 1.000 74 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(3) 187727 3 3 3 1 0 1 0 1 1 0 0.806 0.208 1.000 75 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(6), CD28(3), CD3D(6), CD3E(2), CD3G(3), CD4(6) 1210424 26 16 26 5 3 16 0 0 7 0 0.164 0.240 1.000 76 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(5), IL8(3), SLPI(2) 572860 10 10 9 0 2 5 2 0 1 0 0.0567 0.267 1.000 77 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(8) 264662 8 6 8 1 2 4 2 0 0 0 0.297 0.346 1.000 78 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(8), ATM(54), BRCA1(17), CDKN1A(1), CHEK1(2), CHEK2(14), JUN(1), MAPK8(10), MDM2(4), MRE11A(10), NFKB1(10), NFKBIA(3), RAD50(18), RAD51(2), RBBP8(11), RELA(6), TP53(74), TP73(6) 10702357 251 112 223 46 54 85 53 1 54 4 0.00714 0.387 1.000 79 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 DNAJA3(5), IFNG(9), IFNGR1(4), IFNGR2(4), IKBKB(13), JAK2(17), LIN7A(8), NFKB1(10), NFKBIA(3), RB1(26), RELA(6), TNFRSF1A(4), TNFRSF1B(2), TP53(74), USH1C(13), WT1(3) 6411700 201 95 176 43 54 65 39 2 34 7 0.0119 0.420 1.000 80 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(6), CD3E(2), CD3G(3) 433293 11 7 11 1 1 7 0 0 3 0 0.181 0.429 1.000 81 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(4), APAF1(17), ATM(54), BAD(2), BAX(3), BCL2L1(4), BID(2), CASP3(4), CASP6(7), CASP7(4), CASP9(3), CYCS(2), EIF2S1(2), PRKCA(10), PTK2(12), PXN(6), STAT1(15), TLN1(23), TP53(74) 10101713 248 114 219 46 64 79 55 1 46 3 0.00120 0.443 1.000 82 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(6), CSF1(6), IL6(5), LDLR(6), LPL(16) 1914084 39 23 39 7 10 15 9 0 5 0 0.0571 0.444 1.000 83 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(4), CD34(1), CD3D(6), CD3E(2), CD3G(3), CD4(6), CD58(2), CD8A(2), CSF3(1), IL3(2), IL6(5), IL8(3), KITLG(3) 2309359 40 27 40 9 6 20 4 0 10 0 0.179 0.466 1.000 84 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(6), GSTZ1(5), HGD(4) 822142 15 12 15 2 5 4 4 0 2 0 0.107 0.499 1.000 85 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(5), CCNA2(7), CCND1(14), CCNE1(6), CCNE2(8), CDK2(2), CDK4(3), CDKN1B(7), CDKN2A(2), E2F1(9), E2F2(3), E2F4(3), PRB1(2) 3060313 71 43 69 15 11 26 22 0 12 0 0.115 0.535 1.000 86 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(4), AKT2(6), AKT3(11), BTK(12), CSF2(1), FCER1A(9), FCER1G(2), FYN(7), GAB2(10), GRB2(3), HRAS(1), IL3(2), IL4(1), IL5(2), INPP5D(9), KRAS(53), LCP2(5), LYN(9), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP2K7(4), MAPK1(2), MAPK10(9), MAPK11(3), MAPK12(3), MAPK13(4), MAPK14(4), MAPK3(3), MAPK8(10), MAPK9(5), MS4A2(3), NRAS(9), PDK1(2), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLCG1(12), PLCG2(27), PRKCA(10), PRKCD(5), PRKCE(10), RAC1(1), RAC2(3), RAF1(8), SOS1(13), SOS2(17), SYK(4), VAV1(12), VAV2(7), VAV3(14) 25702425 779 210 600 156 185 271 173 9 124 17 1.07e-06 0.540 1.000 87 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(4), AKT2(6), AKT3(11), BAD(2), CASP9(3), CDC42(4), HRAS(1), KDR(26), KRAS(53), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK11(3), MAPK12(3), MAPK13(4), MAPK14(4), MAPK3(3), MAPKAPK2(6), MAPKAPK3(5), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(5), NOS3(11), NRAS(9), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLCG1(12), PLCG2(27), PPP3CA(4), PPP3CB(5), PPP3CC(6), PPP3R1(1), PPP3R2(3), PRKCA(10), PRKCG(8), PTGS2(9), PTK2(12), PXN(6), RAC1(1), RAC2(3), RAF1(8), SH2D2A(2), SHC2(5), SPHK1(2), SPHK2(2), SRC(3), VEGFA(2) 25185120 749 210 574 157 189 256 164 8 117 15 2.27e-06 0.549 1.000 88 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(11), APC(56), AXIN1(9), BTRC(14), CTNNB1(80), DLL1(7), DVL1(3), FZD1(3), GSK3B(13), NOTCH1(11), PSEN1(5), WNT1(1) 6996633 213 110 154 50 40 113 31 2 24 3 0.0188 0.552 1.000 89 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(6), TPI1(2) 582980 8 7 8 1 0 3 1 0 4 0 0.273 0.560 1.000 90 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 63 AKT1(4), AKT2(6), AKT3(11), BCL10(3), BLNK(4), BTK(12), CARD11(22), CD19(4), CD22(14), CD72(1), CD79A(1), CD79B(2), CHUK(8), CR2(24), FCGR2B(3), FOS(3), GSK3B(13), HRAS(1), IKBKB(13), IKBKG(4), INPP5D(9), JUN(1), KRAS(53), LILRB3(4), LYN(9), MALT1(4), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(5), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NRAS(9), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLCG2(27), PPP3CA(4), PPP3CB(5), PPP3CC(6), PPP3R1(1), PPP3R2(3), PTPN6(6), RAC1(1), RAC2(3), RASGRP3(11), SYK(4), VAV1(12), VAV2(7), VAV3(14) 26552098 781 208 610 160 182 283 167 7 126 16 6.36e-07 0.602 1.000 91 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(9), GOT2(3), TAT(7) 959929 19 13 19 2 7 6 5 1 0 0 0.0879 0.627 1.000 92 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 99 AKT1(4), AKT2(6), AKT3(11), CASP8(21), CCL4(5), CCL5(2), CD14(2), CD40(4), CD80(5), CD86(5), CHUK(8), CXCL10(2), CXCL9(2), FADD(1), FOS(3), IFNA1(2), IFNA10(3), IFNA13(3), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(2), IFNA21(1), IFNA4(3), IFNA5(5), IFNA6(2), IFNA7(1), IFNA8(3), IFNAR1(7), IFNAR2(8), IFNB1(3), IKBKB(13), IKBKE(4), IKBKG(4), IL12A(5), IL12B(2), IL1B(2), IL6(5), IL8(3), IRAK1(4), IRAK4(7), IRF3(2), IRF5(6), IRF7(1), JUN(1), LBP(3), LY96(4), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP2K7(4), MAP3K7(9), MAP3K8(10), MAPK1(2), MAPK10(9), MAPK11(3), MAPK12(3), MAPK13(4), MAPK14(4), MAPK3(3), MAPK8(10), MAPK9(5), MYD88(3), NFKB1(10), NFKB2(9), NFKBIA(3), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), RAC1(1), RELA(6), RIPK1(9), SPP1(2), STAT1(15), TBK1(7), TICAM1(6), TIRAP(2), TLR1(15), TLR2(16), TLR3(10), TLR4(17), TLR5(14), TLR6(14), TLR7(17), TLR8(19), TLR9(6), TOLLIP(1), TRAF3(5), TRAF6(7) 31810954 863 209 730 170 201 289 197 5 153 18 5.19e-08 0.657 1.000 93 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(6), LPL(16), NR3C1(18), PPARG(6), RETN(1), RXRA(3) 1931315 50 24 49 9 12 20 7 1 10 0 0.0290 0.674 1.000 94 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(6), ACAT2(4), HMGCL(2), OXCT1(10) 1250166 22 15 21 3 8 8 3 0 3 0 0.118 0.676 1.000 95 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(19), BMPR1A(5), BMPR1B(6), BMPR2(12) 2246825 42 24 42 6 13 15 7 2 5 0 0.0541 0.685 1.000 96 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(9), GOT1(9), GOT2(3), TAT(7), TYR(12) 1718364 40 20 40 5 11 13 12 1 3 0 0.0253 0.696 1.000 97 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(6), CDK2(2), CDKN1B(7), CKS1B(1), CUL1(13), E2F1(9), RB1(26), RBX1(1), SKP2(7), TFDP1(13) 3169643 85 39 83 18 27 25 17 0 13 3 0.0433 0.712 1.000 98 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(6), ALDOA(5), ALDOB(9), ALDOC(3), TPI1(2) 1409129 25 16 24 4 8 5 5 0 7 0 0.0994 0.774 1.000 99 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(8), APC(56), ATF2(8), AXIN1(9), BMP10(9), BMP2(6), BMP4(10), BMP5(14), BMP7(12), BMPR1A(5), BMPR2(12), CHRD(11), CTNNB1(80), DVL1(3), FZD1(3), GATA4(3), GSK3B(13), MAP3K7(9), MEF2C(11), MYL2(2), NKX2-5(2), NOG(2), NPPA(2), NPPB(3), RFC1(21), TGFB1(2), TGFB2(5), TGFB3(9), TGFBR1(5), TGFBR2(6), TGFBR3(15), WNT1(1) 12863550 357 129 294 73 89 170 54 3 38 3 0.000280 0.809 1.000 100 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(5), ASPH(13), COPS5(5), CREB1(6), EDN1(4), EP300(32), EPO(2), HIF1A(16), JUN(1), LDHA(8), NOS3(11), P4HB(6), VHL(3) 6084806 112 46 111 16 32 32 26 2 20 0 0.000561 0.844 1.000 101 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6) 2104861 40 20 40 6 13 11 9 0 7 0 0.0192 0.869 1.000 102 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(8), SUCLA2(5) 775051 13 10 11 3 8 3 0 0 2 0 0.299 0.876 1.000 103 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 12 CREB1(6), FOS(3), FXYD2(3), JUN(1), KEAP1(8), MAFK(1), MAPK1(2), MAPK14(4), MAPK8(10), NFE2L2(15), PRKCA(10) 3125025 63 38 60 13 18 16 16 3 10 0 0.0513 0.882 1.000 104 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL5(2), CCR3(4), CSF2(1), HLA-DRA(1), IL3(2), IL5(2) 970363 12 11 12 1 3 4 2 0 3 0 0.0945 0.893 1.000 105 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(5), RAB11A(2), RAB1A(5), RAB27A(3), RAB3A(3), RAB4A(5), RAB5A(2), RAB6A(1), RAB9A(6) 1589158 32 17 30 9 13 8 5 0 6 0 0.228 0.895 1.000 106 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(1), FDPS(8), IDI1(3), SQLE(5) 1213914 17 12 17 2 4 8 4 0 1 0 0.167 0.909 1.000 107 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(4), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), HSD3B7(5), PON1(12), PON2(6), PON3(5), RDH11(1), RDH12(5), RDH13(4), RDH14(2) 3235853 60 31 58 11 19 22 10 1 8 0 0.0142 0.910 1.000 108 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(8), IFNG(9), IL12A(5), IL12B(2), IL18(2), IL2(2) 1135018 28 20 27 8 9 9 6 1 3 0 0.506 0.911 1.000 109 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(7), COASY(11), DPYD(20), DPYS(6), ENPP1(12), ENPP3(18), PANK1(3), PANK2(7), PANK3(5), PANK4(5), PPCS(5), UPB1(10) 4910957 109 38 108 21 27 44 26 0 12 0 0.0107 0.928 1.000 110 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(5), CCNE1(6), CDK2(2), CUL1(13), E2F1(9), RB1(26), SKP2(7), TFDP1(13) 3172824 81 39 79 19 28 21 17 0 12 3 0.0698 0.932 1.000 111 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(4), CD4(6), HLA-DRA(1), IL1B(2), IL4(1), IL5(2), IL5RA(9), IL6(5) 1844183 30 21 28 8 4 13 3 0 10 0 0.280 0.943 1.000 112 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(17), BAK1(3), BAX(3), BCL2L1(4), BID(2), BIRC2(10), BIRC3(5), CASP2(6), CASP3(4), CASP6(7), CASP7(4), CASP8(21), CASP9(3), CYCS(2), FADD(1), FAS(9), FASLG(7), GZMB(4), IKBKG(4), JUN(1), MAP2K4(9), MAP3K1(30), MAP3K14(6), MAPK10(9), MCL1(1), MDM2(4), MYC(8), NFKB1(10), NFKBIA(3), PARP1(9), PRF1(8), RELA(6), RIPK1(9), TNFRSF1A(4), TNFRSF1B(2), TNFSF10(1), TP53(74), TRAF1(5), TRAF2(3) 13320502 318 118 287 66 76 108 70 3 59 2 0.000680 0.950 1.000 113 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 4 CDK5(2), FOSB(4), GRIA2(20), PPP1R1B(2) 1282432 28 17 27 8 8 7 6 0 6 1 0.337 0.963 1.000 114 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 9 BAG4(5), BIRC3(5), CASP8(21), FADD(1), RIPK1(9), TNFRSF1A(4), TNFRSF1B(2), TRAF2(3) 2704555 50 30 48 12 10 18 9 0 13 0 0.188 0.974 1.000 115 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP1(2), RANBP2(40), RANGAP1(3) 3100037 46 23 46 8 10 18 10 0 8 0 0.159 0.974 1.000 116 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(14), GABRA2(13), GABRA3(14), GABRA4(19), GABRA5(10), GABRA6(7), PRKCE(10), SOD1(2) 2901805 89 35 84 27 23 35 18 0 13 0 0.264 0.976 1.000 117 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(8), ACTN1(9), ACTR2(6), ACTR3(1), AKT1(4), AKT2(6), AKT3(11), ANGPTL2(6), ARHGEF6(26), ARHGEF7(15), BCAR1(8), BRAF(10), CAV1(2), CDC42(4), CDKN2A(2), CRK(2), CSE1L(14), DOCK1(22), EPHB2(12), FYN(7), GRB2(3), GRB7(4), ILK(5), ITGA1(17), ITGA10(9), ITGA11(7), ITGA2(19), ITGA3(7), ITGA4(10), ITGA5(10), ITGA6(12), ITGA7(14), ITGA8(20), ITGA9(16), ITGB3BP(3), MAP2K4(9), MAP2K7(4), MAP3K11(6), MAPK1(2), MAPK10(9), MAPK8(10), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(9), MAPK9(5), MRAS(1), MYLK(14), MYLK2(8), P4HB(6), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PAK7(9), PIK3CA(172), PIK3CB(17), PKLR(7), PLCG1(12), PLCG2(27), PTEN(228), PTK2(12), RAF1(8), RALA(6), RHO(4), ROCK1(22), ROCK2(17), SHC1(7), SOS1(13), SOS2(17), SRC(3), TERF2IP(2), TLN1(23), TLN2(29), VASP(3), WAS(11), ZYX(11) 44169711 1106 215 893 234 262 338 230 39 205 32 7.28e-09 0.978 1.000 118 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(8), CDC25B(3), CDK7(7), CDKN1A(1), CHEK1(2), NEK1(19), WEE1(2) 2797504 42 22 40 7 14 17 5 0 6 0 0.159 0.979 1.000 119 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(54), ATR(38), BRCA1(17), CCNB1(8), CDC25A(8), CDC25B(3), CDC25C(5), CDKN1A(1), CDKN2D(1), CHEK1(2), CHEK2(14), EP300(32), MDM2(4), MYT1(18), PRKDC(54), RPS6KA1(1), TP53(74), WEE1(2), YWHAH(3), YWHAQ(1) 15904811 340 119 307 64 73 103 83 4 73 4 0.00130 0.979 1.000 120 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA10(7), NDUFA4(1), NDUFA5(4), NDUFA8(5), NDUFB7(3), NDUFS1(13), NDUFS2(7), NDUFV1(3), NDUFV2(2) 2599039 46 28 45 9 18 16 6 1 4 1 0.122 0.979 1.000 121 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(1), GBA3(9), GGT1(5), SHMT1(5), SHMT2(5) 1518951 25 17 25 5 9 9 3 0 4 0 0.108 0.980 1.000 122 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(4), AKT2(6), AKT3(11), BAD(2), BCR(6), BLNK(4), BTK(12), CD19(4), CD22(14), CR2(24), CSK(1), DAG1(6), FLOT1(1), FLOT2(2), GRB2(3), GSK3A(10), GSK3B(13), INPP5D(9), ITPR1(34), ITPR2(35), ITPR3(21), LYN(9), MAP4K1(11), MAPK1(2), MAPK3(3), NFATC1(10), NFATC2(13), NR0B2(2), PDK1(2), PIK3CA(172), PIK3CD(12), PIK3R1(100), PLCG2(27), PPP1R13B(9), PPP3CA(4), PPP3CB(5), PPP3CC(6), PTPRC(17), RAF1(8), SHC1(7), SOS1(13), SOS2(17), SYK(4), VAV1(12) 26363173 687 203 558 152 168 228 155 8 111 17 0.000101 0.987 1.000 123 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(54), CDC25A(8), CDC25B(3), CDC25C(5), CHEK1(2), MYT1(18), WEE1(2), YWHAH(3) 5100102 95 37 90 16 22 34 18 0 18 3 0.0368 0.990 1.000 124 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(8), ABL2(22), AKT1(4), AKT2(6), AKT3(11), ARAF(12), AREG(1), BAD(2), BRAF(10), BTC(2), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CBL(12), CBLB(12), CBLC(5), CDKN1A(1), CDKN1B(7), CRK(2), CRKL(6), EGF(19), EGFR(12), ELK1(3), ERBB2(10), ERBB3(20), ERBB4(27), EREG(3), GAB1(8), GRB2(3), GSK3B(13), HBEGF(2), HRAS(1), JUN(1), KRAS(53), MAP2K1(2), MAP2K2(5), MAP2K4(9), MAP2K7(4), MAPK1(2), MAPK10(9), MAPK3(3), MAPK8(10), MAPK9(5), MYC(8), NCK1(4), NCK2(8), NRAS(9), NRG1(25), NRG2(4), NRG3(17), NRG4(1), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PAK7(9), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLCG1(12), PLCG2(27), PRKCA(10), PRKCG(8), PTK2(12), RAF1(8), RPS6KB1(5), RPS6KB2(4), SHC1(7), SHC2(5), SHC3(15), SHC4(5), SOS1(13), SOS2(17), SRC(3), STAT5A(5), STAT5B(7) 36621303 994 215 813 206 250 351 213 7 154 19 8.05e-08 0.990 1.000 125 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(7), PGLYRP2(5) 631323 12 10 11 7 2 6 1 0 3 0 0.945 0.992 1.000 126 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(9), ENO1(6), GPI(7), HK1(11), PFKL(8), PGAM1(3), PGK1(7), PKLR(7), TPI1(2) 3222973 60 30 59 13 23 20 8 0 9 0 0.0304 0.993 1.000 127 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(3), CD4(6), HLA-DRA(1) 743572 10 10 10 4 3 4 0 0 3 0 0.743 0.993 1.000 128 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(32), EP300(32), LPL(16), NCOA1(19), NCOA2(15), PPARG(6), RXRA(3) 6718199 123 50 119 26 31 36 31 2 22 1 0.0251 0.995 1.000 129 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(6), CYP2C9(5) 748071 11 8 11 5 3 6 0 0 2 0 0.869 0.996 1.000 130 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(10), CLOCK(9), CRY1(9), CRY2(3), CSNK1E(3), PER1(10) 3037182 44 25 43 9 13 16 7 1 7 0 0.156 0.996 1.000 131 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(3), FOSL1(3), FOSL2(7), IFNAR1(7), IFNAR2(8), IFNB1(3), MAPK8(10), NFKB1(10), RELA(6), TNFRSF11A(4), TNFSF11(7), TRAF6(7) 3947890 75 31 73 14 19 26 22 0 8 0 0.0289 0.996 1.000 132 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(7), F13A1(8), F2(8), F2R(6), FGA(26), FGB(7), FGG(10), PLAT(6), PLAU(6), PLG(14), SERPINB2(9), SERPINE1(5) 4979506 112 38 108 25 24 51 25 1 11 0 0.0372 0.997 1.000 133 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(3), BCKDK(6), CBS(11), CTH(6), MUT(10) 1755891 36 22 35 9 10 16 6 0 4 0 0.259 0.998 1.000 134 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(3), LIPT1(5) 566294 8 7 8 4 2 3 2 0 1 0 0.924 0.998 1.000 135 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(32), EP300(32), ESR1(11), MAPK1(2), MAPK3(3), PELP1(11), SRC(3) 5444727 94 47 89 21 26 24 25 1 17 1 0.0704 0.998 1.000 136 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 17 ABCB1(32), AKT1(4), ATM(54), BAX(3), CDKN1A(1), CPB2(7), CSNK1A1(4), CSNK1D(3), FHL2(2), HIF1A(16), IGFBP3(4), MAPK8(10), MDM2(4), NFKBIB(1), NQO1(3), TP53(74) 7267170 222 112 192 48 54 68 49 2 44 5 0.0617 0.998 1.000 137 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(18), CD38(6), ENPP1(12), ENPP3(18), NADSYN1(6), NMNAT1(3), NMNAT2(3), NNMT(6), NNT(7), NT5C(1), NT5E(6), NT5M(3), QPRT(2) 5305520 91 31 89 19 23 37 28 0 3 0 0.0188 0.999 1.000 138 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(9), GAD1(6), HDC(9), PNMT(2), TH(3), TPH1(9) 2023477 38 23 37 10 14 11 8 0 4 1 0.202 0.999 1.000 139 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(6), GSS(5), IL8(3), NFKB1(10), NOX1(16), RELA(6), SOD1(2), XDH(14) 3588806 62 26 62 13 16 22 14 1 9 0 0.0740 0.999 1.000 140 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(2), IFNB1(3), IFNG(9), IL10(3), IL12A(5), IL12B(2), IL15(2), IL16(16), IL18(2), IL2(2), IL3(2), IL4(1), IL5(2), IL6(5), IL8(3), IL9(1), LTA(3) 3525903 63 26 62 18 16 27 12 1 7 0 0.191 0.999 1.000 141 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(7), BFAR(7), BRAF(10), CAMP(1), CREB1(6), CREB5(5), MAPK1(2), RAF1(8), SNX13(15), SRC(3), TERF2IP(2) 4244786 66 28 65 15 14 27 14 1 10 0 0.203 0.999 1.000 142 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 6 B3GNT1(5), FUT1(4), FUT2(1), FUT9(9), GCNT2(11), ST8SIA1(2) 1973787 32 18 32 8 16 11 5 0 0 0 0.116 0.999 1.000 143 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(4), ARG1(5), GLS(11), GLUD1(3), OAT(7), PRODH(12) 2002359 42 22 39 11 13 13 8 1 7 0 0.257 0.999 1.000 144 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(2), CALM2(4), CAMK1(2), CAMK1G(5), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CAMK4(5), CAMKK1(13), CAMKK2(7), CREB1(6), SYT1(4) 4149292 70 29 68 15 26 26 9 0 9 0 0.0268 1.000 1.000 145 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(4), GPLD1(13), PGAP1(17), PIGA(8), PIGB(11), PIGC(3), PIGF(2), PIGG(6), PIGH(5), PIGK(9), PIGL(1), PIGM(1), PIGN(13), PIGO(9), PIGP(3), PIGQ(5), PIGS(1), PIGT(7), PIGU(3), PIGV(7), PIGW(9), PIGX(2), PIGZ(5) 8968278 144 49 141 28 36 57 35 0 16 0 0.00262 1.000 1.000 146 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(5), CCNB1(8), CCND1(14), CCND2(9), CCND3(4), CCNE1(6), CCNH(7), CDC25A(8), CDK2(2), CDK4(3), CDK6(3), CDK7(7), CDKN1A(1), CDKN1B(7), CDKN2A(2), CDKN2C(4), CDKN2D(1), E2F1(9), RB1(26), RBL1(13), TFDP1(13) 5680949 152 55 146 31 45 42 32 0 30 3 0.0101 1.000 1.000 147 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(2), IFNAR1(7), IFNAR2(8), IFNB1(3), JAK1(20), STAT1(15), STAT2(8), TYK2(10) 3919832 73 30 71 20 21 21 21 0 10 0 0.256 1.000 1.000 148 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(9), NFYB(2), NFYC(3), RB1(26), SP1(7), SP3(10) 2477280 57 27 54 11 16 14 14 0 10 3 0.146 1.000 1.000 149 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(5), ASL(2), CPS1(23), GLS(11), GLUD1(3), GOT1(9) 2808232 53 22 52 12 12 22 8 1 8 2 0.216 1.000 1.000 150 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(8), CCNH(7), CDC25A(8), CDC25B(3), CDC25C(5), CDK7(7), SHH(4), XPO1(18) 3154343 60 25 57 12 24 15 14 0 7 0 0.0956 1.000 1.000 151 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SEC61A2(4), SRP19(3), SRP54(8), SRP68(5), SRP72(11), SRP9(1), SRPR(11) 2776480 44 21 44 9 10 22 6 0 6 0 0.246 1.000 1.000 152 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 19 B3GNT1(5), B3GNT2(1), B3GNT3(5), B3GNT4(4), B3GNT5(6), B4GALT1(2), B4GALT2(5), B4GALT3(10), B4GALT4(5), FUT1(4), FUT2(1), FUT3(8), FUT5(1), FUT6(10), FUT7(2), FUT9(9), GCNT2(11), ST3GAL6(6), ST8SIA1(2) 5116187 97 36 96 21 42 33 12 1 9 0 0.0119 1.000 1.000 153 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(6), ENO2(4), ENO3(5), FARS2(2), GOT1(9), GOT2(3), PAH(2), TAT(7), YARS(5) 3043413 43 21 43 10 15 14 10 1 3 0 0.175 1.000 1.000 154 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(6), CD8A(2), CSF1(6), CSF2(1), CSF3(1), EPO(2), IL11(2), IL2(2), IL3(2), IL4(1), IL5(2), IL6(5), IL7(1), IL8(3), IL9(1) 2235970 37 29 37 12 10 16 4 1 6 0 0.395 1.000 1.000 155 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CSF2(1), CSF3(1), EPO(2), FLT3(16), IGF1(5), IL11(2), IL3(2), IL6(5), IL9(1), KITLG(3), TGFB1(2), TGFB2(5), TGFB3(9) 3069442 54 28 52 13 14 23 10 0 7 0 0.158 1.000 1.000 156 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(1), FDPS(8), GGPS1(2), IDI1(3), IDI2(1), SQLE(5) 1613940 20 13 20 5 5 10 4 0 1 0 0.474 1.000 1.000 157 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(56), AXIN1(9), CREBBP(32), CTNNB1(80), DVL1(3), EP300(32), FZD1(3), GSK3B(13), HDAC1(5), LDB1(5), LEF1(9), PITX2(12), TRRAP(42), WNT1(1) 11871781 302 125 238 76 62 134 53 4 44 5 0.0220 1.000 1.000 158 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 16 ADAM10(4), ANKRD1(7), ATF3(3), CYR61(3), DUSP14(4), EIF4E(2), HBEGF(2), IFNG(9), IFRD1(6), IL18(2), IL1R1(5), MYOG(1), NR4A3(9), WDR1(9) 3908198 66 27 66 16 16 27 14 0 9 0 0.214 1.000 1.000 159 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(19), EGFR(12), ERBB3(20), NRG1(25) 3749909 76 34 73 17 21 30 15 0 10 0 0.144 1.000 1.000 160 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(17), ARHGAP5(21), ARHGDIB(3), CASP1(8), CASP10(8), CASP3(4), CASP8(21), CASP9(3), CYCS(2), GZMB(4), JUN(1), PRF1(8) 4727581 100 34 96 26 21 36 20 0 22 1 0.299 1.000 1.000 161 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(3), LDLR(6), NR0B2(2), NR1H3(4), NR1H4(7), RXRA(3) 1864144 25 17 25 7 9 6 4 1 5 0 0.328 1.000 1.000 162 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(6), ACAT2(4), BDH1(3), BDH2(4), HMGCL(2), HMGCS1(6), HMGCS2(9), OXCT1(10), OXCT2(2) 2682095 46 25 45 11 14 19 8 1 4 0 0.203 1.000 1.000 163 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(5), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), HEMK1(3), LCMT1(2), LCMT2(9), METTL2B(4), METTL6(5), PRMT2(4), PRMT3(9), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), WBSCR22(5) 5308040 89 33 87 20 24 39 9 1 16 0 0.0284 1.000 1.000 164 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(2), JAK1(20), JAK2(17), JAK3(10), PIAS1(7), PIAS3(9), PTPRU(19), REG1A(4), SOAT1(9) 5010873 97 37 96 24 29 32 17 1 15 3 0.114 1.000 1.000 165 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(6), DCN(11), FMOD(5), KERA(10), LUM(12) 1337449 44 19 40 12 14 18 7 0 5 0 0.254 1.000 1.000 166 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(2), IFNG(9), IFNGR1(4), JAK1(20), JAK2(17), PTPRU(19), REG1A(4), STAT1(15) 4199450 90 36 89 24 32 26 15 0 14 3 0.205 1.000 1.000 167 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(2), IL6(5), IL6R(7), JAK1(20), JAK2(17), JAK3(10), PIAS3(9), PTPRU(19), REG1A(4), SRC(3), STAT3(10) 5492541 106 41 105 28 28 35 21 1 18 3 0.137 1.000 1.000 168 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(4), CD28(3), CD3D(6), CD3E(2), CD3G(3), CD4(6), ICAM1(2), ITGAL(17), ITGB2(14), PTPRC(17), THY1(1) 4083120 75 36 74 25 22 31 9 1 12 0 0.352 1.000 1.000 169 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(14), F2(8), F2R(6), F3(6), F5(48), F7(2), FGA(26), FGB(7), FGG(10), PROC(5), PROS1(21), SERPINC1(10), TFPI(9) 5927459 172 42 164 37 37 86 32 1 15 1 0.0228 1.000 1.000 170 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(3), ECHS1(3), HADH(1), HADHA(6), HADHB(4), HSD17B10(4), HSD17B4(13), MECR(5), PPT1(3), PPT2(1) 3035384 43 27 42 11 7 16 15 1 4 0 0.293 1.000 1.000 171 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(6), CHRNA1(7), SNAP25(9), STX1A(1) 1177188 23 15 22 6 14 2 6 0 1 0 0.301 1.000 1.000 172 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(6), CD3E(2), CD3G(3), CD4(6), FYN(7), HLA-DRA(1), LCK(5), PTPRC(17), ZAP70(8) 3156865 55 25 55 16 13 23 8 0 11 0 0.349 1.000 1.000 173 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(14), FOS(3), GRB2(3), HRAS(1), IL3(2), IL3RA(9), JAK2(17), MAP2K1(2), MAPK3(3), PTPN6(6), RAF1(8), SHC1(7), SOS1(13), STAT5A(5), STAT5B(7) 6359638 100 44 96 26 30 44 20 0 3 3 0.121 1.000 1.000 174 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 38 ANAPC1(21), ANAPC10(2), ANAPC2(6), ANAPC4(5), ANAPC5(8), ANAPC7(5), BTRC(14), CDC16(12), CDC20(4), CDC23(7), CUL1(13), CUL2(12), CUL3(14), FBXW11(5), FBXW7(46), FZR1(2), ITCH(10), RBX1(1), SKP2(7), SMURF1(12), SMURF2(7), TCEB1(2), TCEB2(2), UBA1(17), UBE2C(1), UBE2D2(4), UBE2D3(2), UBE2D4(2), UBE2E1(3), UBE2E2(3), UBE2E3(7), VHL(3), WWP1(19), WWP2(9) 14140270 287 91 267 61 94 87 60 2 43 1 0.00550 1.000 1.000 175 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 11 APAF1(17), BAD(2), BAK1(3), BAX(3), BCL10(3), BCL2L1(4), BCL2L11(6), BID(2), CASP9(3), CES1(13) 2783428 56 27 55 13 9 23 16 0 8 0 0.224 1.000 1.000 176 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 14 ACTA1(5), APAF1(17), CASP3(4), CASP9(3), CYCS(2), DAXX(10), FAS(9), FASLG(7), HSPB2(1), MAPKAPK2(6), MAPKAPK3(5) 3917860 69 27 68 15 15 25 19 0 10 0 0.102 1.000 1.000 177 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(4), CD28(3), CD3D(6), CD3E(2), CD3G(3), CD8A(2), ICAM1(2), ITGAL(17), ITGB2(14), PTPRC(17), THY1(1) 3842727 71 32 70 24 23 28 9 1 10 0 0.320 1.000 1.000 178 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(6), CD3D(6), CD3E(2), CD3G(3), CXCR3(5), ETV5(3), IFNG(9), IL12A(5), IL12B(2), IL12RB1(13), IL12RB2(10), IL18(2), IL18R1(9), JAK2(17), JUN(1), MAP2K6(10), MAPK14(4), MAPK8(10), STAT4(7), TYK2(10) 6885170 134 42 132 30 30 50 32 1 18 3 0.0442 1.000 1.000 179 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(3), CD3D(6), CD3E(2), CD3G(3), GZMB(4), HLA-A(1), ICAM1(2), ITGAL(17), ITGB2(14), PRF1(8) 3051150 60 32 58 19 25 22 4 1 8 0 0.127 1.000 1.000 180 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(2), ATP5O(1), ATP6AP1(8), ATP6V0A1(7), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(7), SHMT1(5) 5607042 107 44 105 29 29 41 13 0 24 0 0.197 1.000 1.000 181 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(2), ATP5O(1), ATP6AP1(8), ATP6V0A1(7), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(7), SHMT1(5) 5607042 107 44 105 29 29 41 13 0 24 0 0.197 1.000 1.000 182 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(2), ATP5O(1), ATP6AP1(8), ATP6V0A1(7), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(7), SHMT1(5) 5607042 107 44 105 29 29 41 13 0 24 0 0.197 1.000 1.000 183 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(3), ALAS1(8), ALAS2(11), CPO(3), FECH(7), GATA1(8), HBA1(1), HBA2(1), HBB(2), HMBS(8), UROD(3), UROS(3) 3008529 58 28 56 15 19 23 10 0 6 0 0.216 1.000 1.000 184 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(9), ELK1(3), EPO(2), EPOR(4), FOS(3), GRB2(3), HRAS(1), JAK2(17), JUN(1), MAP2K1(2), MAPK3(3), MAPK8(10), PLCG1(12), PTPN6(6), RAF1(8), SHC1(7), SOS1(13), STAT5A(5), STAT5B(7) 7811814 116 48 109 28 33 48 26 0 6 3 0.0671 1.000 1.000 185 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(21), ADRB2(7), CFTR(14), GNAS(24), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), SLC9A3R1(3) 4521301 96 36 92 26 38 28 15 1 13 1 0.126 1.000 1.000 186 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5E(2), ATP5O(1), ATP6AP1(8), ATP6V0A1(7), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(7), FDXR(3), SHMT1(5) 5871170 110 44 108 29 30 41 15 0 24 0 0.157 1.000 1.000 187 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(7), ACOX3(8), FADS2(2), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9) 3783753 62 33 59 18 25 20 6 2 9 0 0.187 1.000 1.000 188 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(14), AGT(8), AGTR1(4), AGTR2(11), BDKRB2(8), KNG1(12), NOS3(11), REN(4) 3394668 72 29 69 20 31 29 6 1 5 0 0.0733 1.000 1.000 189 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(10), CLOCK(9), CRY1(9), CRY2(3), CSNK1D(3), CSNK1E(3), NPAS2(14), NR1D1(3), PER1(10), PER2(13), PER3(15) 6067688 92 40 88 23 31 32 15 1 13 0 0.0684 1.000 1.000 190 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(2), FARSA(6), FARSB(7), GOT1(9), GOT2(3), PAH(2), TAT(7), YARS(5), YARS2(3) 3194444 44 24 44 11 16 14 11 1 2 0 0.240 1.000 1.000 191 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(3), CD86(5), HLA-DRA(1), IFNG(9), IFNGR1(4), IFNGR2(4), IL12A(5), IL12B(2), IL12RB1(13), IL12RB2(10), IL18(2), IL18R1(9), IL2(2), IL2RA(4), IL4(1), IL4R(6) 4551927 80 32 79 26 27 26 15 1 11 0 0.346 1.000 1.000 192 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP3(4), CASP8(21), CFL1(1), CFLAR(6), PDE6D(2) 1403178 34 19 32 11 4 15 6 0 9 0 0.660 1.000 1.000 193 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 9 ALDOA(5), CTSD(4), ESR1(11), GREB1(20), HSPB2(1), MTA1(6), MTA3(6), PDZK1(5), TUBA8(7) 3584758 65 39 64 17 21 18 16 3 7 0 0.107 1.000 1.000 194 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(7), IARS(8), LARS(18), LARS2(8), PDHA1(7), PDHA2(9), PDHB(3) 3714074 60 23 59 15 11 28 11 0 10 0 0.436 1.000 1.000 195 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(22), C5(18), C6(16), C7(20), C8A(9), C9(19) 4725130 104 33 99 27 21 45 23 0 13 2 0.219 1.000 1.000 196 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(6), IL1B(2), MST1(4), MST1R(12) 2135450 24 17 22 9 11 7 2 0 4 0 0.632 1.000 1.000 197 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 20 BAD(2), BAX(3), CASP8(21), CYCS(2), FADD(1), MAP2K1(2), MAP2K4(9), MAP3K1(30), MAPK1(2), MAPK3(3), MAPK8(10), NFKB1(10), NSMAF(9), RAF1(8), RELA(6), RIPK1(9), SMPD1(11), TNFRSF1A(4), TRAF2(3) 7275526 145 51 140 32 31 52 27 0 34 1 0.0416 1.000 1.000 198 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(5), COQ5(5), COQ6(4), COQ7(3), NDUFA13(1), NDUFB11(3) 1527536 21 17 21 8 8 8 3 0 2 0 0.729 1.000 1.000 199 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2) 4869763 71 28 70 21 26 22 13 2 8 0 0.169 1.000 1.000 200 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(17), BAK1(3), BAX(3), BCL2L1(4), BID(2), BIK(2), BIRC2(10), BIRC3(5), CASP3(4), CASP6(7), CASP7(4), CASP8(21), CASP9(3), CYCS(2), DFFB(4), DIABLO(2), ENDOG(1) 4938447 94 33 91 25 15 38 20 0 21 0 0.376 1.000 1.000 201 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(12), BID(2), BRAF(10), CASP3(4), CD244(6), CD247(5), CD48(2), CSF2(1), FAS(9), FASLG(7), FCER1G(2), FCGR3A(1), FCGR3B(2), FYN(7), GRB2(3), GZMB(4), HCST(1), HLA-A(1), HLA-B(3), HLA-C(2), HLA-E(1), HLA-G(2), HRAS(1), ICAM1(2), ICAM2(3), IFNA1(2), IFNA10(3), IFNA13(3), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(2), IFNA21(1), IFNA4(3), IFNA5(5), IFNA6(2), IFNA7(1), IFNA8(3), IFNAR1(7), IFNAR2(8), IFNB1(3), IFNG(9), IFNGR1(4), IFNGR2(4), ITGAL(17), ITGB2(14), KIR2DL1(5), KIR2DL3(1), KIR2DL4(4), KIR3DL1(10), KIR3DL2(5), KLRC1(7), KLRC2(3), KLRC3(1), KLRD1(3), KLRK1(1), KRAS(53), LCK(5), LCP2(5), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), MICA(3), MICB(2), NCR1(6), NCR2(3), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(5), NRAS(9), PAK1(3), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLCG1(12), PLCG2(27), PPP3CA(4), PPP3CB(5), PPP3CC(6), PPP3R1(1), PPP3R2(3), PRF1(8), PRKCA(10), PRKCG(8), PTK2B(16), PTPN11(8), PTPN6(6), RAC1(1), RAC2(3), RAF1(8), SH2D1A(7), SH2D1B(4), SH3BP2(7), SHC1(7), SHC2(5), SHC3(15), SHC4(5), SOS1(13), SOS2(17), SYK(4), TNFRSF10A(2), TNFRSF10B(5), TNFRSF10C(4), TNFRSF10D(6), TNFSF10(1), TYROBP(1), ULBP1(2), ULBP2(5), ULBP3(2), VAV1(12), VAV2(7), VAV3(14), ZAP70(8) 40242749 1020 212 838 241 253 375 227 8 140 17 1.23e-05 1.000 1.000 202 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(7), CDO1(4), CSAD(6), GAD1(6), GAD2(12), GGT1(5) 2063029 40 22 40 13 8 13 12 2 5 0 0.484 1.000 1.000 203 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(2), APEX1(2), CREBBP(32), DFFB(4), GZMA(6), GZMB(4), HMGB2(4), NME1(2), PRF1(8), SET(7) 3880986 71 34 67 20 23 23 11 0 13 1 0.221 1.000 1.000 204 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM1(2), CALM2(4), CALML3(3), CALML6(4), CDS1(5), DGKA(10), DGKB(22), DGKD(18), DGKE(5), DGKG(11), DGKH(11), DGKI(20), DGKQ(2), DGKZ(10), FN3K(5), IMPA1(4), IMPA2(6), INPP1(3), INPP4A(21), INPP4B(16), INPP5A(5), INPP5B(5), INPP5D(9), INPP5E(1), INPPL1(17), ITPK1(4), ITPKA(1), ITPKB(11), ITPR1(34), ITPR2(35), ITPR3(21), OCRL(19), PI4KA(17), PI4KB(9), PIK3C2A(22), PIK3C2B(10), PIK3C2G(16), PIK3C3(14), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PIP4K2A(5), PIP4K2B(7), PIP4K2C(3), PIP5K1A(8), PIP5K1B(5), PIP5K1C(5), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PLCD1(5), PLCD3(3), PLCD4(11), PLCE1(41), PLCG1(12), PLCG2(27), PLCZ1(14), PRKCA(10), PRKCG(8), PTEN(228), PTPMT1(2), SYNJ1(29), SYNJ2(11) 45436750 1259 223 1030 287 301 354 257 42 261 44 1.25e-05 1.000 1.000 205 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(7), HLCS(6), SPCS3(2) 1133663 15 10 15 9 2 4 8 0 1 0 0.955 1.000 1.000 206 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(1), GALT(3), TGDS(4), UGDH(2), UGP2(6), UXS1(5) 1872620 21 15 20 9 7 7 5 0 2 0 0.859 1.000 1.000 207 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(4), INPP1(3), INPP4A(21), INPP4B(16), INPP5A(5), INPPL1(17), ITPKA(1), ITPKB(11), MIOX(6), OCRL(19), PIK3C2A(22), PIK3C2B(10), PIK3C2G(16), PIK3CA(172), PIK3CB(17), PIK3CG(23), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PLCD1(5), PLCG1(12), PLCG2(27) 16343503 450 161 346 102 130 147 118 5 49 1 0.00189 1.000 1.000 208 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(21), GNAS(24), GNB1(2), GNGT1(1), PRKACA(6), PRKAR1A(4) 2172411 58 29 56 15 29 14 8 0 7 0 0.211 1.000 1.000 209 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 12 CNR1(12), CNR2(6), DNMT1(14), MTNR1A(5), MTNR1B(4), PTAFR(4), PTGDR(9), PTGER2(3), PTGER4(12), PTGFR(13), PTGIR(3) 3658357 85 41 82 26 32 33 16 0 4 0 0.0986 1.000 1.000 210 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(22), AGT(8), AGTR1(4), AGTR2(11), CMA1(2), COL4A1(21), COL4A2(12), COL4A3(26), COL4A4(23), COL4A5(26), COL4A6(32), REN(4) 9494645 191 49 186 48 41 102 25 2 18 3 0.0439 1.000 1.000 211 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(5), ACP2(1), ACP5(5), ACPP(5), ACPT(5), ENPP1(12), ENPP3(18), FLAD1(5), RFK(1), TYR(12) 3572293 69 26 69 17 11 27 27 0 4 0 0.278 1.000 1.000 212 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(5), ACP2(1), ACP5(5), ACP6(4), ACPP(5), ACPT(5), ENPP1(12), ENPP3(18), FLAD1(5), LHPP(2), MTMR1(16), MTMR2(5), MTMR6(10), PHPT1(1), RFK(1), TYR(12) 5503174 107 34 106 28 19 42 32 0 14 0 0.301 1.000 1.000 213 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(6), CREM(8), FOS(3), JUN(1), MAPK3(3), OPRK1(10), POLR2A(21), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3) 4652266 79 35 77 23 30 22 15 1 10 1 0.148 1.000 1.000 214 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(9), IFNGR1(4), IFNGR2(4), JAK1(20), JAK2(17), STAT1(15) 3049904 69 31 68 22 19 22 14 0 11 3 0.570 1.000 1.000 215 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 8 CAMK1(2), CAMK1G(5), HDAC9(16), MEF2A(3), MEF2B(1), MEF2C(11), MEF2D(7), YWHAH(3) 2977293 48 19 46 14 18 12 11 0 7 0 0.289 1.000 1.000 216 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 9 B3GALT1(12), B3GALT2(8), B3GALT5(4), B3GNT5(6), FUT1(4), FUT2(1), FUT3(8), ST3GAL3(10), ST3GAL4(3) 2404103 56 24 54 16 20 17 10 1 8 0 0.252 1.000 1.000 217 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CSNK2A1(9), ELK1(3), FOS(3), GRB2(3), HRAS(1), IL6(5), IL6R(7), IL6ST(11), JAK1(20), JAK2(17), JAK3(10), JUN(1), MAP2K1(2), MAPK3(3), PTPN11(8), RAF1(8), SHC1(7), SOS1(13), SRF(3), STAT3(10) 8536621 144 55 138 34 32 55 35 0 19 3 0.0587 1.000 1.000 218 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(5), CDKN1A(1), EPO(2), EPOR(4), GRIN1(4), HIF1A(16), JAK2(17), NFKB1(10), NFKBIA(3), RELA(6), SOD2(3) 4546138 71 30 71 20 17 27 15 1 8 3 0.325 1.000 1.000 219 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(8), APOBEC1(7), APOBEC2(4), APOBEC3A(1), APOBEC3B(6), APOBEC3C(4), APOBEC3F(6), APOBEC3G(3), APOBEC4(5) 2713493 44 21 44 12 15 18 9 1 1 0 0.353 1.000 1.000 220 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(7), IFNB1(3), JAK1(20), PTPRU(19), REG1A(4), STAT1(15), STAT2(8), TYK2(10) 4502550 86 34 85 24 34 23 19 0 10 0 0.174 1.000 1.000 221 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(7), BCAT2(3), COASY(11), DPYD(20), DPYS(6), ENPP1(12), ENPP3(18), ILVBL(8), PANK1(3), PANK2(7), PANK3(5), PANK4(5), PPCDC(1), PPCS(5), UPB1(10), VNN1(9) 6157106 130 43 126 32 39 48 30 0 13 0 0.0477 1.000 1.000 222 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 150 AKT1(4), AKT2(6), AKT3(11), BCL2L1(4), CBL(12), CBLB(12), CBLC(5), CCND1(14), CCND2(9), CCND3(4), CISH(2), CLCF1(1), CNTF(3), CNTFR(2), CREBBP(32), CRLF2(5), CSF2(1), CSF2RA(12), CSF2RB(14), CSF3(1), CSF3R(7), EP300(32), EPO(2), EPOR(4), GH1(3), GH2(3), GHR(8), GRB2(3), IFNA1(2), IFNA10(3), IFNA13(3), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(2), IFNA21(1), IFNA4(3), IFNA5(5), IFNA6(2), IFNA7(1), IFNA8(3), IFNAR1(7), IFNAR2(8), IFNB1(3), IFNG(9), IFNGR1(4), IFNGR2(4), IFNK(2), IFNW1(3), IL10(3), IL10RA(4), IL10RB(6), IL11(2), IL11RA(5), IL12A(5), IL12B(2), IL12RB1(13), IL12RB2(10), IL13RA1(13), IL13RA2(7), IL15(2), IL19(2), IL2(2), IL20(9), IL20RA(3), IL21(3), IL21R(7), IL22RA1(4), IL22RA2(1), IL23A(4), IL23R(5), IL24(7), IL26(3), IL28A(3), IL28B(2), IL28RA(9), IL29(2), IL2RA(4), IL2RB(3), IL2RG(13), IL3(2), IL3RA(9), IL4(1), IL4R(6), IL5(2), IL5RA(9), IL6(5), IL6R(7), IL6ST(11), IL7(1), IL7R(12), IL9(1), IL9R(7), IRF9(4), JAK1(20), JAK2(17), JAK3(10), LEP(2), LEPR(12), LIF(3), LIFR(27), MPL(7), MYC(8), OSM(2), OSMR(13), PIAS1(7), PIAS2(15), PIAS3(9), PIAS4(5), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PIM1(3), PRL(6), PRLR(5), PTPN11(8), PTPN6(6), SOCS2(6), SOCS4(5), SOCS5(12), SOCS7(5), SOS1(13), SOS2(17), SPRED1(3), SPRED2(8), SPRY1(3), SPRY2(5), SPRY3(6), SPRY4(2), STAM(7), STAM2(5), STAT1(15), STAT2(8), STAT3(10), STAT4(7), STAT5A(5), STAT5B(7), STAT6(10), TPO(15), TSLP(2), TYK2(10) 52598979 1247 219 1105 281 290 441 289 11 192 24 2.79e-07 1.000 1.000 223 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 13 CHUK(8), DUSP1(2), IKBKAP(13), IKBKB(13), IKBKG(4), MAP3K1(30), MAP3K14(6), NFKB1(10), NFKBIA(3), RELA(6), TNFAIP3(3), TRAF3(5), TRAF6(7) 6780716 110 40 109 25 25 42 20 1 20 2 0.107 1.000 1.000 224 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(21), CREM(8), FHL5(7), FSHR(16), GNAS(24), XPO1(18) 3289447 94 30 88 22 39 28 17 0 10 0 0.153 1.000 1.000 225 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(3), ST3GAL1(2), ST3GAL2(6), ST3GAL4(3), ST3GAL5(5), ST6GALNAC2(4), ST6GALNAC4(4), ST8SIA1(2) 1942787 29 21 28 10 13 11 4 0 1 0 0.398 1.000 1.000 226 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 93 AKT1(4), AKT2(6), AKT3(11), BCL10(3), CARD11(22), CBL(12), CBLB(12), CBLC(5), CD247(5), CD28(3), CD3D(6), CD3E(2), CD3G(3), CD4(6), CD40LG(6), CD8A(2), CD8B(1), CDC42(4), CDK4(3), CHUK(8), CSF2(1), CTLA4(2), FOS(3), FYN(7), GRB2(3), HRAS(1), ICOS(3), IFNG(9), IKBKB(13), IKBKG(4), IL10(3), IL2(2), IL4(1), IL5(2), ITK(7), JUN(1), KRAS(53), LCK(5), LCP2(5), MALT1(4), MAP3K14(6), MAP3K8(10), NCK1(4), NCK2(8), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(5), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NRAS(9), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PAK7(9), PDCD1(3), PDK1(2), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLCG1(12), PPP3CA(4), PPP3CB(5), PPP3CC(6), PPP3R1(1), PPP3R2(3), PRKCQ(9), PTPN6(6), PTPRC(17), RASGRP1(8), RHOA(3), SOS1(13), SOS2(17), TEC(8), VAV1(12), VAV2(7), VAV3(14), ZAP70(8) 36166709 919 211 741 213 224 316 201 11 150 17 0.000181 1.000 1.000 227 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(1), GALT(3), TGDS(4), UGDH(2), UXS1(5) 1484004 15 12 15 9 4 6 4 0 1 0 0.960 1.000 1.000 228 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(1), DCXR(1), GUSB(5), RPE(5), UCHL1(4), UCHL3(1), UGDH(2), UGT1A1(6), UGT1A10(7), UGT1A3(2), UGT1A4(5), UGT1A5(7), UGT1A6(3), UGT1A7(7), UGT1A8(5), UGT1A9(3), UGT2B15(9), UGT2B4(11) 6412129 84 31 82 19 21 40 11 1 11 0 0.0840 1.000 1.000 229 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(13), IL13RA2(7), IL4R(6), JAK1(20), JAK2(17), TYK2(10) 3765029 73 32 73 23 15 24 19 1 11 3 0.524 1.000 1.000 230 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(13), IL13RA2(7), IL4R(6), JAK1(20), JAK2(17), TYK2(10) 3765029 73 32 73 23 15 24 19 1 11 3 0.524 1.000 1.000 231 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH9A1(2) 2852783 50 24 49 18 17 18 8 2 5 0 0.416 1.000 1.000 232 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH9A1(2) 2852783 50 24 49 18 17 18 8 2 5 0 0.416 1.000 1.000 233 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(9), PARK2(6), SNCA(3), SNCAIP(12), UBE2E2(3), UBE2F(3), UBE2G1(2), UBE2L3(2), UBE2L6(3) 2308876 43 21 43 14 10 19 9 0 4 1 0.477 1.000 1.000 234 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(5), ALDOB(9), ALDOC(3), FBP1(2), FBP2(1), GOT1(9), GOT2(3), GPT(2), GPT2(5), MDH1(4), MDH2(4), ME1(12), ME2(8), ME3(9), PGK1(7), PKLR(7), PKM2(5), RPE(5), RPIA(9), TKT(6), TPI1(2) 6427743 117 46 114 30 38 46 19 2 12 0 0.0488 1.000 1.000 235 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(8), CREBBP(32), EP300(32), FADD(1), HDAC3(12), IKBKB(13), IKBKG(4), NFKB1(10), NFKBIA(3), RELA(6), RIPK1(9), TNFRSF1A(4), TNFRSF1B(2), TRAF6(7) 7984364 143 51 137 33 40 43 29 1 28 2 0.0387 1.000 1.000 236 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(12), EIF2AK4(7), EIF2B5(5), EIF2S1(2), EIF2S2(9), EIF2S3(6), EIF5(3), GSK3B(13), PPP1CA(3) 4163661 60 28 57 14 18 20 6 3 13 0 0.279 1.000 1.000 237 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 31 ABP1(5), ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), ALDH1A3(8), ALDH3A1(7), ALDH3B2(7), AOC2(7), AOC3(10), AOX1(18), COMT(3), DBH(9), DCT(13), DDC(9), FAH(6), GOT1(9), GOT2(3), GSTZ1(5), HGD(4), HPD(2), MAOA(12), MAOB(7), PNMT(2), TAT(7), TH(3), TPO(15), TYR(12) 11116639 223 57 218 60 69 75 50 2 27 0 0.0178 1.000 1.000 238 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), ESCO1(16), ESCO2(8), NAT6(1), PNPLA3(7), SH3GLB1(7) 6018126 55 26 55 12 16 25 7 0 7 0 0.133 1.000 1.000 239 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(4), GRB2(3), IL2RG(13), IL4(1), IL4R(6), IRS1(13), JAK1(20), JAK3(10), RPS6KB1(5), SHC1(7), STAT6(10) 5172677 92 41 92 29 27 33 17 1 14 0 0.381 1.000 1.000 240 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(7), BCAT2(3), IARS(8), IARS2(20), ILVBL(8), LARS(18), LARS2(8), PDHA1(7), PDHA2(9), PDHB(3), VARS(6), VARS2(1) 5974162 98 33 95 26 31 36 17 0 14 0 0.300 1.000 1.000 241 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(8), ACTB(3), ACTG1(6), ARHGEF2(8), ARPC5(1), CD14(2), CDC42(4), CDH1(14), CLDN1(3), CTNNB1(80), CTTN(3), EZR(4), FYN(7), HCLS1(12), ITGB1(8), KRT18(1), LY96(4), NCK1(4), NCK2(8), NCL(7), OCLN(2), PRKCA(10), RHOA(3), ROCK1(22), ROCK2(17), TLR4(17), TLR5(14), TUBA1A(9), TUBA1B(3), TUBA1C(5), TUBA3C(5), TUBA3D(4), TUBA3E(10), TUBA4A(11), TUBA8(7), TUBAL3(6), TUBB1(5), TUBB2A(2), TUBB2B(2), TUBB3(6), TUBB6(5), TUBB8(4), WAS(11), WASL(8), YWHAQ(1), YWHAZ(1) 18662298 377 127 319 100 95 171 68 4 37 2 0.00810 1.000 1.000 242 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(8), ACTB(3), ACTG1(6), ARHGEF2(8), ARPC5(1), CD14(2), CDC42(4), CDH1(14), CLDN1(3), CTNNB1(80), CTTN(3), EZR(4), FYN(7), HCLS1(12), ITGB1(8), KRT18(1), LY96(4), NCK1(4), NCK2(8), NCL(7), OCLN(2), PRKCA(10), RHOA(3), ROCK1(22), ROCK2(17), TLR4(17), TLR5(14), TUBA1A(9), TUBA1B(3), TUBA1C(5), TUBA3C(5), TUBA3D(4), TUBA3E(10), TUBA4A(11), TUBA8(7), TUBAL3(6), TUBB1(5), TUBB2A(2), TUBB2B(2), TUBB3(6), TUBB6(5), TUBB8(4), WAS(11), WASL(8), YWHAQ(1), YWHAZ(1) 18662298 377 127 319 100 95 171 68 4 37 2 0.00810 1.000 1.000 243 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(17), EGF(19), EGFR(12), HGS(8), RAB5A(2), TF(14), TFRC(4) 4655220 76 28 74 24 20 28 15 0 13 0 0.478 1.000 1.000 244 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(21), COL4A2(12), COL4A3(26), COL4A4(23), COL4A5(26), COL4A6(32), P4HB(6), SLC23A1(8), SLC23A2(7), SLC2A1(2), SLC2A3(8) 9449324 171 49 167 49 42 85 22 2 17 3 0.101 1.000 1.000 245 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(4), CD36(8), FOS(3), FYN(7), JUN(1), MAPK14(4), THBS1(11) 2646788 38 21 38 13 12 13 8 0 5 0 0.538 1.000 1.000 246 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(6), ACAT2(4), ACOT11(5), ACYP1(2), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), ECHS1(3), EHHADH(11), ESCO1(16), ESCO2(8), FN3K(5), GCDH(6), HADHA(6), NAT6(1), PNPLA3(7), SH3GLB1(7), YOD1(3) 9402046 106 42 106 29 25 48 21 0 12 0 0.253 1.000 1.000 247 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(5), CHPT1(1), HEMK1(3), LCMT1(2), LCMT2(9), METTL2B(4), METTL6(5), PCYT1A(4), PCYT1B(4), PRMT2(4), PRMT3(9), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), WBSCR22(5) 5002863 82 32 80 24 21 36 8 2 15 0 0.281 1.000 1.000 248 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(8), ACADM(9), ACADS(3), ACAT1(6), ECHS1(3), HADHA(6) 1930428 35 18 35 12 6 15 11 0 3 0 0.664 1.000 1.000 249 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 32 CD14(2), CHUK(8), ELK1(3), FOS(3), IKBKB(13), IKBKG(4), IRAK1(4), JUN(1), LY96(4), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP3K1(30), MAP3K14(6), MAP3K7(9), MAPK14(4), MAPK8(10), MYD88(3), NFKB1(10), NFKBIA(3), PPARA(1), RELA(6), TIRAP(2), TLR10(19), TLR2(16), TLR3(10), TLR4(17), TLR6(14), TLR7(17), TLR9(6), TOLLIP(1), TRAF6(7) 13189970 259 66 256 56 58 102 54 1 40 4 0.00293 1.000 1.000 250 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(5), ACTR2(6), ACTR3(1), ARPC1A(6), ARPC1B(5), ARPC2(1), ARPC3(1), ARPC4(1), CDC42(4), RAC1(1), WASF1(3), WASL(8) 3012972 42 22 42 13 16 17 2 0 7 0 0.427 1.000 1.000 251 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(10), CPEB1(9), EGFR(12), ERBB2(10), ERBB4(27), ETS1(6), ETS2(6), ETV6(6), ETV7(4), FMN2(27), GRB2(3), KRAS(53), MAP2K1(2), MAPK1(2), MAPK3(3), NOTCH1(11), NOTCH2(18), NOTCH3(29), NOTCH4(9), PIWIL1(21), PIWIL2(14), PIWIL3(10), PIWIL4(14), RAF1(8), SOS1(13), SOS2(17), SPIRE1(9), SPIRE2(4) 17642222 357 110 303 82 89 166 63 6 32 1 0.00155 1.000 1.000 252 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(6), CSF1R(8), DDX20(4), E2F1(9), E2F4(3), ETS1(6), ETS2(6), ETV3(11), FOS(3), HDAC2(5), HDAC5(12), HRAS(1), JUN(1), NCOR2(23), RBL1(13), RBL2(19), SIN3A(29), SIN3B(13) 9425937 172 61 165 43 58 49 34 0 30 1 0.0298 1.000 1.000 253 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(1), DCXR(1), GUSB(5), RPE(5), UGDH(2), UGP2(6), UGT1A1(6), UGT1A10(7), UGT1A3(2), UGT1A4(5), UGT1A5(7), UGT1A6(3), UGT1A7(7), UGT1A8(5), UGT1A9(3), UGT2A1(11), UGT2A3(5), UGT2B10(18), UGT2B11(18), UGT2B15(9), UGT2B17(7), UGT2B28(21), UGT2B4(11), UGT2B7(5), XYLB(5) 9582049 175 40 166 33 36 83 32 1 23 0 0.00332 1.000 1.000 254 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(8), ACADM(9), ACADS(3), ACADVL(9), ACSL1(14), ACSL3(7), ACSL4(21), CPT1A(9), CPT2(4), EHHADH(11), HADHA(6), PECR(6), SCP2(9), SLC25A20(4) 6111523 120 37 116 31 31 46 28 0 15 0 0.123 1.000 1.000 255 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(5), ACAD9(8), ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), ESCO1(16), ESCO2(8), NAT6(1), PNPLA3(7), SH3GLB1(7) 9147786 108 34 108 24 33 41 17 0 16 1 0.0386 1.000 1.000 256 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(5), ANXA2(4), ANXA3(3), ANXA4(9), ANXA5(3), ANXA6(11), CYP11A1(9), EDN1(4), EDNRA(5), EDNRB(4), HPGD(6), HSD11B1(6), PLA2G4A(13), PRL(6), PTGDR(9), PTGDS(5), PTGER2(3), PTGER4(12), PTGFR(13), PTGIR(3), PTGIS(7), PTGS1(6), PTGS2(9), SCGB1A1(2), TBXAS1(7) 7412477 164 50 163 40 47 67 30 2 18 0 0.0192 1.000 1.000 257 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(6), ADCY3(12), ADCY9(27), AK1(1), ARF1(3), ARF3(4), ARF4(3), ARF5(4), ARF6(3), ARL4D(1), ATP6V0A1(7), ATP6V0A2(12), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(11), ATP6V1A(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1E2(4), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(7), ERO1L(6), GNAS(24), PDIA4(5), PLCG1(12), PLCG2(27), PRKCA(10), SEC61A1(5), SEC61A2(4), SEC61B(2), SEC61G(3), TRIM23(11) 13444408 272 65 265 66 94 90 48 3 35 2 0.00367 1.000 1.000 258 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), ECHS1(3), EHHADH(11), HADH(1), HADHA(6), HSD17B10(4), HSD17B4(13), NTAN1(3), SIRT1(6), SIRT2(8), SIRT5(5), SIRT7(6), VNN2(11) 4305314 78 29 76 24 20 32 19 0 7 0 0.499 1.000 1.000 259 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(17), BAD(2), BAK1(3), BAX(3), BCL2L1(4), BCL2L11(6), BID(2), BIRC2(10), BIRC3(5), BIRC5(4), BNIP3L(1), CASP1(8), CASP10(8), CASP2(6), CASP3(4), CASP4(5), CASP6(7), CASP7(4), CASP8(21), CASP9(3), CHUK(8), CYCS(2), DFFB(4), FADD(1), FAS(9), FASLG(7), GZMB(4), HELLS(11), IKBKB(13), IKBKG(4), IRF1(1), IRF2(6), IRF3(2), IRF4(8), IRF5(6), IRF6(9), IRF7(1), JUN(1), LTA(3), MAP2K4(9), MAP3K1(30), MAPK10(9), MDM2(4), MYC(8), NFKB1(10), NFKBIA(3), NFKBIB(1), NFKBIE(6), PLEKHG5(5), PRF1(8), RELA(6), RIPK1(9), TNFRSF10B(5), TNFRSF1A(4), TNFRSF1B(2), TNFRSF21(5), TNFRSF25(3), TNFSF10(1), TP53(74), TP73(6), TRAF1(5), TRAF2(3), TRAF3(5) 20246836 444 129 412 107 111 167 77 3 83 3 0.00379 1.000 1.000 260 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(21), COL4A2(12), COL4A3(26), COL4A4(23), COL4A5(26), COL4A6(32), F10(14), F11(15), F12(2), F2(8), F2R(6), F5(48), F8(45), F9(14), FGA(26), FGB(7), FGG(10), KLKB1(10), PROC(5), PROS1(21), SERPINC1(10), SERPING1(7) 16412302 388 69 371 93 87 184 67 2 44 4 0.00834 1.000 1.000 261 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(5), ALDOB(9), ALDOC(3), FBP1(2), FBP2(1), GOT1(9), GOT2(3), GPT(2), GPT2(5), MDH1(4), MDH2(4), ME1(12), ME3(9), PGK1(7), PGK2(6), PKLR(7), PKM2(5), RPE(5), RPIA(9), TKT(6), TKTL1(9), TKTL2(16), TPI1(2) 7208802 140 53 135 37 48 56 18 2 16 0 0.0340 1.000 1.000 262 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 16 ALOX12(8), ALOX15(9), ALOX15B(6), ALOX5(10), ALOX5AP(3), DPEP1(3), GGT1(5), LTA4H(4), PLA2G6(9), PTGDS(5), PTGES(2), PTGIS(7), PTGS1(6), PTGS2(9), TBXAS1(7) 5401004 93 33 91 27 40 29 17 1 6 0 0.130 1.000 1.000 263 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(12), EGF(19), EGFR(12), GRB2(3), HRAS(1), MAP2K1(2), MAPK1(2), MAPK3(3), PTPRB(31), RAF1(8), RASA1(30), SHC1(7), SOS1(13), SPRY1(3), SPRY2(5), SPRY3(6), SPRY4(2), SRC(3) 9178228 162 61 155 37 40 59 38 0 24 1 0.0477 1.000 1.000 264 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 14 CHUK(8), MAP3K14(6), MAPK14(4), MAPK8(10), NFKB1(10), RELA(6), TNFRSF13B(3), TNFRSF17(1), TNFSF13B(5), TRAF2(3), TRAF3(5), TRAF5(7), TRAF6(7) 5225351 75 37 74 21 20 25 15 1 14 0 0.315 1.000 1.000 265 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(18), CAPN1(5), CAPNS1(2), CAPNS2(3), CDK5(2), CDK5R1(3), CSNK1A1(4), CSNK1D(3), GSK3B(13), MAPT(9), PPP2CA(6) 3361556 68 29 67 22 31 18 9 0 10 0 0.322 1.000 1.000 266 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(4), EGFR(12), IGF1R(13), MYC(8), POLR2A(21), PPP2CA(6), PRKCA(10), RB1(26), TEP1(13), TERF1(1), TERT(4), TNKS(15), TP53(74), XRCC5(8) 10199390 215 105 188 58 80 53 39 3 37 3 0.0393 1.000 1.000 267 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(3), CALR(3), CANX(5), CD4(6), CD74(1), CD8A(2), CD8B(1), CIITA(15), CREB1(6), CTSL1(5), CTSS(4), HLA-A(1), HLA-B(3), HLA-C(2), HLA-DMA(3), HLA-DOA(3), HLA-DOB(3), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(1), HLA-DRB5(1), HLA-E(1), HLA-F(3), HLA-G(2), HSP90AA1(7), HSP90AB1(21), HSPA5(6), IFI30(1), IFNA1(2), IFNA10(3), IFNA13(3), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(2), IFNA21(1), IFNA4(3), IFNA5(5), IFNA6(2), IFNA7(1), IFNA8(3), KIR2DL1(5), KIR2DL3(1), KIR2DL4(4), KIR2DS4(5), KIR3DL1(10), KIR3DL2(5), KIR3DL3(3), KLRC1(7), KLRC2(3), KLRC3(1), KLRC4(5), KLRD1(3), LGMN(7), LTA(3), NFYA(9), NFYB(2), NFYC(3), PDIA3(5), PSME1(1), PSME2(4), RFX5(9), RFXANK(4), RFXAP(2), TAP1(8), TAP2(1), TAPBP(4) 15021381 262 62 253 65 67 123 42 0 29 1 0.00852 1.000 1.000 268 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 NRF1(5), TAX1BP3(1), UBE2A(3), UBE2B(3), UBE2C(1), UBE2D2(4), UBE2D3(2), UBE2E1(3), UBE2E3(7), UBE2G1(2), UBE2H(1), UBE2J1(1), UBE2L3(2), UBE2L6(3), UBE2N(4), UBE3A(16) 3762990 58 27 58 20 16 15 16 2 9 0 0.630 1.000 1.000 269 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(53), MAP2(31), PPP1CA(3), PPP2CA(6), PRKACB(3), PRKACG(9), PRKAG1(3), PRKAR2A(4), PRKAR2B(3), PRKCE(10) 6652974 125 40 122 31 24 50 29 0 19 3 0.231 1.000 1.000 270 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(3), F13B(15), HSD17B1(4), HSD17B2(2), HSD17B3(6), HSD17B4(13), HSD17B7(5), HSD3B1(3), HSD3B2(6) 2949521 57 30 55 21 12 27 6 0 12 0 0.689 1.000 1.000 271 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(54), CCNA1(5), CCNB1(8), CCND1(14), CCND2(9), CCND3(4), CCNE1(6), CCNE2(8), CCNG2(2), CCNH(7), CDC25A(8), CDK2(2), CDK4(3), CDK7(7), CDKN1A(1), CDKN1B(7), CDKN2A(2), CDKN2C(4), CDKN2D(1), CREB3L1(3), CREB3L3(7), CREB3L4(6), E2F1(9), E2F2(3), E2F3(4), E2F4(3), E2F5(6), E2F6(1), GBA2(13), MCM2(7), MCM3(9), MCM4(11), MCM5(8), MCM6(6), MCM7(6), MDM2(4), MYC(8), MYT1(18), NACA(20), PCNA(3), POLA2(3), POLE(47), POLE2(4), PRIM1(3), RB1(26), RBL1(13), RPA1(6), RPA2(3), RPA3(3), TFDP1(13), TFDP2(6), TNXB(19), TP53(74), WEE1(2) 27079694 529 146 480 126 148 189 103 3 80 6 0.00152 1.000 1.000 272 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(22), C5(18), C6(16), C7(20), ICAM1(2), IL6(5), IL8(3), ITGA4(10), ITGAL(17), ITGB1(8), ITGB2(14), SELP(12), SELPLG(9), VCAM1(12) 9034468 168 51 161 46 43 72 25 1 25 2 0.0577 1.000 1.000 273 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(17), ACO2(7), AFMID(6), CS(6), GRHPR(3), HAO1(3), HAO2(10), HYI(2), MDH1(4), MDH2(4), MTHFD1(6), MTHFD1L(15), MTHFD2(4) 4944780 87 39 85 28 39 24 18 0 6 0 0.247 1.000 1.000 274 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(4), PSMA2(4), PSMA3(5), PSMA4(2), PSMA5(2), PSMA6(1), PSMA7(2), PSMB1(2), PSMB10(4), PSMB2(2), PSMB3(2), PSMB4(1), PSMB5(4), PSMB6(4), PSMB7(2), PSMB8(2), PSMB9(1) 3015723 44 23 42 14 12 12 8 0 12 0 0.536 1.000 1.000 275 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(3), ACTG1(6), ACTN1(9), ACTN2(16), ACTN3(10), ACTN4(8), AKT1(4), AKT2(6), AKT3(11), ARHGAP5(21), BAD(2), BCAR1(8), BIRC2(10), BIRC3(5), BRAF(10), CAPN2(11), CAV1(2), CAV2(1), CCND1(14), CCND2(9), CCND3(4), CDC42(4), CHAD(3), COL11A1(37), COL11A2(10), COL1A1(12), COL1A2(24), COL2A1(15), COL3A1(19), COL4A1(21), COL4A2(12), COL4A4(23), COL4A6(32), COL5A1(29), COL5A2(21), COL5A3(19), COL6A1(5), COL6A2(14), COL6A3(44), COL6A6(27), COMP(6), CRK(2), CRKL(6), CTNNB1(80), DIAPH1(12), DOCK1(22), EGF(19), EGFR(12), ELK1(3), ERBB2(10), FARP2(15), FIGF(5), FLNA(40), FLNB(34), FLNC(37), FLT1(20), FN1(43), FYN(7), GRB2(3), GSK3B(13), HGF(14), HRAS(1), IBSP(7), IGF1(5), IGF1R(13), ILK(5), ITGA1(17), ITGA10(9), ITGA11(7), ITGA2(19), ITGA2B(10), ITGA3(7), ITGA4(10), ITGA5(10), ITGA6(12), ITGA7(14), ITGA8(20), ITGA9(16), ITGAV(10), ITGB1(8), ITGB3(11), ITGB4(8), ITGB5(8), ITGB6(7), ITGB7(4), ITGB8(9), JUN(1), KDR(26), LAMA1(30), LAMA2(61), LAMA3(30), LAMA4(15), LAMA5(17), LAMB1(23), LAMB2(26), LAMB3(16), LAMB4(32), LAMC1(18), LAMC2(17), LAMC3(17), MAP2K1(2), MAPK1(2), MAPK10(9), MAPK3(3), MAPK8(10), MAPK9(5), MET(17), MYL2(2), MYL5(1), MYL7(3), MYL9(3), MYLK(14), MYLK2(8), MYLPF(2), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PAK7(9), PARVA(4), PARVB(2), PARVG(8), PDGFA(3), PDGFB(2), PDGFC(3), PDGFD(8), PDGFRA(24), PDGFRB(12), PDPK1(3), PGF(3), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PIP5K1C(5), PPP1CA(3), PPP1CB(9), PPP1CC(4), PPP1R12A(8), PRKCA(10), PRKCG(8), PTEN(228), PTK2(12), PXN(6), RAC1(1), RAC2(3), RAF1(8), RAP1A(4), RAP1B(2), RAPGEF1(11), RELN(48), RHOA(3), ROCK1(22), ROCK2(17), SHC1(7), SHC2(5), SHC3(15), SHC4(5), SOS1(13), SOS2(17), SPP1(2), SRC(3), THBS1(11), THBS2(20), THBS3(3), THBS4(12), TLN1(23), TLN2(29), TNC(26), TNN(19), TNR(14), TNXB(19), VASP(3), VAV1(12), VAV2(7), VAV3(14), VCL(11), VEGFA(2), VEGFB(2), VEGFC(6), VTN(3), VWF(25), ZYX(11) 132352116 2810 237 2488 764 737 1006 502 59 442 64 2.64e-07 1.000 1.000 276 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 199 ABI2(4), ACTN1(9), ACTN2(16), ACTN3(10), ACTN4(8), APC(56), ARAF(12), ARHGEF1(12), ARHGEF12(29), ARHGEF4(9), ARHGEF6(26), ARHGEF7(15), ARPC1A(6), ARPC1B(5), ARPC2(1), ARPC3(1), ARPC4(1), ARPC5(1), BAIAP2(5), BCAR1(8), BDKRB1(3), BDKRB2(8), BRAF(10), CD14(2), CDC42(4), CFL1(1), CFL2(8), CHRM1(6), CHRM2(10), CHRM3(8), CHRM4(9), CHRM5(9), CRK(2), CRKL(6), CSK(1), CYFIP1(9), CYFIP2(20), DIAPH1(12), DIAPH2(31), DIAPH3(25), DOCK1(22), EGF(19), EGFR(12), EZR(4), F2(8), F2R(6), FGD1(15), FGD3(9), FGF10(2), FGF11(1), FGF12(5), FGF13(4), FGF14(4), FGF17(1), FGF18(1), FGF21(1), FGF23(3), FGF3(1), FGF5(9), FGF6(2), FGF7(5), FGF8(4), FGF9(1), FGFR1(10), FGFR2(34), FGFR3(6), FGFR4(14), FN1(43), GIT1(9), GNA12(8), GNA13(7), GNG12(1), GSN(5), HRAS(1), INS(3), IQGAP1(12), IQGAP2(24), IQGAP3(16), ITGA1(17), ITGA10(9), ITGA11(7), ITGA2(19), ITGA2B(10), ITGA3(7), ITGA4(10), ITGA5(10), ITGA6(12), ITGA7(14), ITGA8(20), ITGA9(16), ITGAD(10), ITGAE(9), ITGAL(17), ITGAM(21), ITGAV(10), ITGAX(14), ITGB1(8), ITGB2(14), ITGB3(11), ITGB4(8), ITGB5(8), ITGB6(7), ITGB7(4), ITGB8(9), KRAS(53), LIMK1(8), LIMK2(15), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), MOS(6), MRAS(1), MSN(18), MYH10(29), MYH14(23), MYH9(22), MYL2(2), MYL5(1), MYL7(3), MYL9(3), MYLK(14), MYLK2(8), MYLPF(2), NCKAP1(8), NCKAP1L(20), NRAS(9), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PAK7(9), PDGFA(3), PDGFB(2), PDGFRA(24), PDGFRB(12), PFN1(1), PFN2(2), PFN4(2), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PIP4K2A(5), PIP4K2B(7), PIP4K2C(3), PIP5K1A(8), PIP5K1B(5), PIP5K1C(5), PPP1CA(3), PPP1CB(9), PPP1CC(4), PPP1R12A(8), PPP1R12B(20), PTK2(12), PXN(6), RAC1(1), RAC2(3), RAF1(8), RDX(16), RHOA(3), ROCK1(22), ROCK2(17), RRAS(3), RRAS2(4), SCIN(6), SLC9A1(8), SOS1(13), SOS2(17), SSH1(17), SSH2(13), SSH3(4), TIAM1(27), TIAM2(14), VAV1(12), VAV2(7), VAV3(14), VCL(11), WAS(11), WASF1(3), WASF2(3), WASL(8) 100375796 2100 225 1870 599 573 763 403 27 303 31 0.000441 1.000 1.000 277 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 107 ACTN1(9), ACTN2(16), ACTN3(10), ACTN4(8), ARHGAP5(21), BCAR1(8), CD99(1), CDC42(4), CDH5(6), CLDN1(3), CLDN10(7), CLDN11(2), CLDN15(5), CLDN16(4), CLDN17(4), CLDN18(7), CLDN19(2), CLDN2(3), CLDN20(3), CLDN22(2), CLDN8(4), CLDN9(3), CTNNA1(18), CTNNA2(16), CTNNA3(13), CTNNB1(80), CTNND1(27), CXCL12(6), CXCR4(1), CYBA(2), CYBB(9), ESAM(1), EZR(4), F11R(1), GNAI1(5), GNAI2(6), GNAI3(4), ICAM1(2), ITGA4(10), ITGAL(17), ITGAM(21), ITGB1(8), ITGB2(14), ITK(7), JAM2(9), JAM3(3), MAPK11(3), MAPK12(3), MAPK13(4), MAPK14(4), MLLT4(21), MMP2(7), MMP9(12), MSN(18), MYL2(2), MYL5(1), MYL7(3), MYL9(3), MYLPF(2), NCF1(3), NCF2(8), NCF4(5), NOX1(16), NOX3(7), OCLN(2), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLCG1(12), PLCG2(27), PRKCA(10), PRKCG(8), PTK2(12), PTK2B(16), PTPN11(8), PXN(6), RAC1(1), RAC2(3), RAP1A(4), RAP1B(2), RAPGEF3(10), RAPGEF4(15), RASSF5(3), RHOA(3), RHOH(1), ROCK1(22), ROCK2(17), SIPA1(1), THY1(1), TXK(6), VASP(3), VAV1(12), VAV2(7), VAV3(14), VCAM1(12), VCL(11) 44542115 1137 221 948 291 284 409 235 12 177 20 0.000531 1.000 1.000 278 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 128 ACACA(33), ACACB(29), AKT1(4), AKT2(6), AKT3(11), ARAF(12), BAD(2), BRAF(10), CALM1(2), CALM2(4), CALML3(3), CALML6(4), CBL(12), CBLB(12), CBLC(5), CRK(2), CRKL(6), ELK1(3), EXOC7(4), FASN(7), FBP1(2), FBP2(1), FLOT1(1), FLOT2(2), FOXO1(12), G6PC(5), G6PC2(11), GCK(3), GRB2(3), GSK3B(13), GYS1(13), GYS2(16), HRAS(1), IKBKB(13), INPP5D(9), INS(3), INSR(18), IRS1(13), IRS4(20), KRAS(53), LIPE(13), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK10(9), MAPK3(3), MAPK8(10), MAPK9(5), MKNK1(3), MKNK2(3), NRAS(9), PCK1(9), PCK2(7), PDE3A(19), PDE3B(15), PDPK1(3), PFKL(8), PFKM(9), PFKP(8), PHKA1(20), PHKA2(21), PHKB(15), PHKG1(7), PHKG2(3), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PKLR(7), PKM2(5), PPARGC1A(9), PPP1CA(3), PPP1CB(9), PPP1CC(4), PPP1R3A(32), PPP1R3B(2), PPP1R3C(4), PRKAA1(8), PRKAA2(10), PRKAB1(6), PRKAB2(1), PRKACA(6), PRKACB(3), PRKACG(9), PRKAG1(3), PRKAG2(4), PRKAG3(6), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCI(6), PRKCZ(3), PRKX(2), PTPN1(5), PTPRF(27), PYGB(11), PYGL(8), PYGM(10), RAF1(8), RAPGEF1(11), RHEB(3), RHOQ(1), RPS6(7), RPS6KB1(5), RPS6KB2(4), SH2B2(1), SHC1(7), SHC2(5), SHC3(15), SHC4(5), SLC2A4(9), SOCS2(6), SOCS4(5), SORBS1(18), SOS1(13), SOS2(17), SREBF1(2), TRIP10(10), TSC1(12), TSC2(15) 56199251 1338 221 1144 337 387 449 263 15 203 21 2.27e-06 1.000 1.000 279 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 142 APC(56), AXIN1(9), AXIN2(9), BTRC(14), CACYBP(2), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CCND1(14), CCND2(9), CCND3(4), CER1(4), CHD8(34), CREBBP(32), CSNK1A1(4), CSNK1A1L(4), CSNK1E(3), CSNK2A1(9), CSNK2A2(4), CTBP1(1), CTBP2(5), CTNNB1(80), CUL1(13), CXXC4(1), DAAM1(18), DAAM2(10), DKK1(3), DKK2(3), DKK4(3), DVL1(3), DVL2(10), DVL3(9), EP300(32), FBXW11(5), FOSL1(3), FZD1(3), FZD10(9), FZD2(8), FZD3(9), FZD4(4), FZD5(2), FZD6(13), FZD7(4), FZD8(2), FZD9(6), GSK3B(13), JUN(1), LEF1(9), LRP5(14), LRP6(26), MAP3K7(9), MAPK10(9), MAPK8(10), MAPK9(5), MYC(8), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(5), NKD1(3), NLK(5), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PORCN(12), PPARD(3), PPP2CA(6), PPP2CB(4), PPP2R1A(30), PPP2R1B(6), PPP2R2A(10), PPP2R2B(12), PPP2R2C(2), PPP3CA(4), PPP3CB(5), PPP3CC(6), PPP3R1(1), PPP3R2(3), PRICKLE1(6), PRICKLE2(3), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(10), PRKCG(8), PRKX(2), PSEN1(5), RAC1(1), RAC2(3), RBX1(1), RHOA(3), ROCK1(22), ROCK2(17), RUVBL1(3), SENP2(12), SFRP1(6), SFRP2(4), SFRP4(9), SFRP5(2), SIAH1(6), SMAD2(9), SMAD3(7), SMAD4(5), SOX17(7), TBL1X(8), TBL1XR1(15), TCF7(3), TCF7L1(4), TCF7L2(11), TP53(74), VANGL1(6), VANGL2(10), WIF1(5), WNT1(1), WNT10A(2), WNT10B(2), WNT11(6), WNT16(7), WNT2(3), WNT2B(6), WNT3(3), WNT3A(1), WNT4(1), WNT5A(7), WNT5B(3), WNT6(1), WNT7A(3), WNT7B(2), WNT8A(2), WNT8B(5), WNT9A(4), WNT9B(2) 56493350 1173 217 1053 318 383 413 219 10 140 8 5.62e-05 1.000 1.000 280 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 129 ACTB(3), ACTG1(6), ACTN1(9), ACTN2(16), ACTN3(10), ACTN4(8), AKT1(4), AKT2(6), AKT3(11), AMOTL1(12), ASH1L(42), CASK(18), CDC42(4), CDK4(3), CGN(14), CLDN1(3), CLDN10(7), CLDN11(2), CLDN15(5), CLDN16(4), CLDN17(4), CLDN18(7), CLDN19(2), CLDN2(3), CLDN20(3), CLDN22(2), CLDN8(4), CLDN9(3), CRB3(1), CSDA(4), CSNK2A1(9), CSNK2A2(4), CTNNA1(18), CTNNA2(16), CTNNA3(13), CTNNB1(80), CTTN(3), EPB41(11), EPB41L1(15), EPB41L2(14), EPB41L3(17), EXOC3(8), EXOC4(6), F11R(1), GNAI1(5), GNAI2(6), GNAI3(4), HCLS1(12), HRAS(1), IGSF5(5), INADL(20), JAM2(9), JAM3(3), KRAS(53), LLGL1(10), LLGL2(7), MAGI1(23), MAGI2(28), MAGI3(16), MLLT4(21), MPDZ(22), MPP5(10), MRAS(1), MYH1(45), MYH10(29), MYH11(33), MYH13(22), MYH14(23), MYH15(23), MYH2(43), MYH3(30), MYH4(31), MYH6(16), MYH7(35), MYH7B(16), MYH8(29), MYH9(22), MYL2(2), MYL5(1), MYL7(3), MYL9(3), MYLPF(2), NRAS(9), OCLN(2), PARD3(19), PARD6B(3), PARD6G(1), PPM1J(3), PPP2CA(6), PPP2CB(4), PPP2R1A(30), PPP2R1B(6), PPP2R2A(10), PPP2R2B(12), PPP2R2C(2), PPP2R3A(12), PPP2R3B(9), PPP2R4(5), PRKCA(10), PRKCD(5), PRKCE(10), PRKCG(8), PRKCH(10), PRKCI(6), PRKCQ(9), PRKCZ(3), PTEN(228), RAB13(3), RAB3B(2), RHOA(3), RRAS(3), RRAS2(4), SPTAN1(31), SRC(3), SYMPK(17), TJAP1(6), TJP1(24), TJP2(16), TJP3(7), VAPA(6), YES1(8), ZAK(15) 70594305 1669 216 1426 457 442 588 281 52 267 39 0.00128 1.000 1.000 281 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 246 ACVR1B(9), ACVR1C(6), AKT1(4), AKT2(6), AKT3(11), ARRB1(4), ARRB2(4), ATF2(8), ATF4(3), BDNF(7), BRAF(10), CACNA1A(19), CACNA1B(35), CACNA1C(38), CACNA1D(29), CACNA1E(59), CACNA1F(41), CACNA1G(24), CACNA1H(12), CACNA1I(8), CACNA1S(33), CACNA2D1(14), CACNA2D2(10), CACNA2D3(22), CACNA2D4(15), CACNB1(12), CACNB2(13), CACNB3(5), CACNB4(13), CACNG1(1), CACNG2(3), CACNG3(10), CACNG4(6), CACNG5(4), CACNG6(4), CACNG7(7), CACNG8(1), CASP3(4), CD14(2), CDC25B(3), CDC42(4), CHUK(8), CRK(2), CRKL(6), DAXX(10), DDIT3(2), DUSP1(2), DUSP10(5), DUSP14(4), DUSP16(11), DUSP3(2), DUSP5(4), DUSP6(2), DUSP7(3), DUSP8(1), DUSP9(1), ECSIT(5), EGF(19), EGFR(12), ELK1(3), ELK4(3), FAS(9), FASLG(7), FGF10(2), FGF11(1), FGF12(5), FGF13(4), FGF14(4), FGF17(1), FGF18(1), FGF21(1), FGF23(3), FGF3(1), FGF5(9), FGF6(2), FGF7(5), FGF8(4), FGF9(1), FGFR1(10), FGFR2(34), FGFR3(6), FGFR4(14), FLNA(40), FLNB(34), FLNC(37), FOS(3), GADD45G(1), GNA12(8), GNG12(1), GRB2(3), HRAS(1), IKBKB(13), IKBKG(4), IL1B(2), IL1R1(5), IL1R2(5), JUN(1), KRAS(53), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K4(9), MAP2K5(3), MAP2K6(10), MAP2K7(4), MAP3K1(30), MAP3K10(7), MAP3K12(8), MAP3K13(13), MAP3K14(6), MAP3K2(12), MAP3K3(9), MAP3K4(21), MAP3K5(25), MAP3K6(7), MAP3K7(9), MAP3K8(10), MAP4K1(11), MAP4K2(7), MAP4K3(16), MAP4K4(11), MAPK1(2), MAPK10(9), MAPK11(3), MAPK12(3), MAPK13(4), MAPK14(4), MAPK3(3), MAPK7(14), MAPK8(10), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(9), MAPK9(5), MAPKAPK2(6), MAPKAPK3(5), MAPKAPK5(5), MAPT(9), MAX(12), MEF2C(11), MKNK1(3), MKNK2(3), MOS(6), MRAS(1), MYC(8), NF1(36), NFATC2(13), NFATC4(5), NFKB1(10), NFKB2(9), NLK(5), NR4A1(5), NRAS(9), NTF3(5), NTRK1(13), NTRK2(13), PAK1(3), PAK2(3), PDGFA(3), PDGFB(2), PDGFRA(24), PDGFRB(12), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PPM1A(6), PPM1B(4), PPP3CA(4), PPP3CB(5), PPP3CC(6), PPP3R1(1), PPP3R2(3), PPP5C(7), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(10), PRKCG(8), PRKX(2), PTPN5(8), PTPN7(6), PTPRR(17), RAC1(1), RAC2(3), RAF1(8), RAP1A(4), RAP1B(2), RAPGEF2(30), RASA1(30), RASA2(11), RASGRF1(11), RASGRF2(18), RASGRP1(8), RASGRP2(4), RASGRP3(11), RASGRP4(6), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), RPS6KA4(2), RPS6KA5(11), RPS6KA6(19), RRAS(3), RRAS2(4), SOS1(13), SOS2(17), SRF(3), STK3(12), STK4(9), STMN1(4), TAOK1(12), TAOK2(9), TAOK3(5), TGFB1(2), TGFB2(5), TGFB3(9), TGFBR1(5), TGFBR2(6), TNFRSF1A(4), TP53(74), TRAF2(3), TRAF6(7), ZAK(15) 104048776 2099 200 1966 642 661 763 373 29 258 15 0.000271 1.000 1.000 282 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(8), ACVR1B(9), ACVRL1(2), AKT1(4), AURKB(4), BMPR1A(5), BMPR2(12), BUB1(10), CDKL1(8), CDKL2(5), CDS1(5), CLK1(7), CLK2(9), CLK4(6), COL4A3BP(3), CSNK2A1(9), CSNK2A2(4), DGKA(10), DGKB(22), DGKD(18), DGKE(5), DGKG(11), DGKH(11), DGKQ(2), DGKZ(10), IMPA1(4), INPP1(3), INPP4A(21), INPP4B(16), INPP5A(5), INPPL1(17), ITPKA(1), ITPKB(11), MAP3K10(7), MOS(6), NEK1(19), NEK3(7), OCRL(19), PIK3C2A(22), PIK3C2B(10), PIK3C2G(16), PIK3CA(172), PIK3CB(17), PIK3CG(23), PIM2(5), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PLCD1(5), PLCG1(12), PLCG2(27), PLK3(8), PRKACA(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(10), PRKCD(5), PRKCE(10), PRKCG(8), PRKCH(10), PRKCQ(9), PRKCZ(3), PRKD1(8), PRKG1(11), RAF1(8), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), RPS6KA4(2), RPS6KB1(5), STK11(2), TGFBR1(5), VRK1(12) 41274078 870 183 754 257 252 293 211 10 102 2 0.112 1.000 1.000 283 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), CALM1(2), CALM2(4), CALML3(3), CALML6(4), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CREB1(6), CREB3L1(3), CREB3L2(7), CREB3L3(7), CREB3L4(6), CREBBP(32), CTNNB1(80), DCT(13), DVL1(3), DVL2(10), DVL3(9), EDN1(4), EDNRB(4), EP300(32), FZD1(3), FZD10(9), FZD2(8), FZD3(9), FZD4(4), FZD5(2), FZD6(13), FZD7(4), FZD8(2), FZD9(6), GNAI1(5), GNAI2(6), GNAI3(4), GNAO1(7), GNAQ(3), GNAS(24), GSK3B(13), HRAS(1), KIT(24), KITLG(3), KRAS(53), LEF1(9), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), MC1R(3), MITF(6), NRAS(9), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), POMC(4), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(10), PRKCG(8), PRKX(2), RAF1(8), TCF7(3), TCF7L1(4), TCF7L2(11), TYR(12), TYRP1(7), WNT1(1), WNT10A(2), WNT10B(2), WNT11(6), WNT16(7), WNT2(3), WNT2B(6), WNT3(3), WNT3A(1), WNT4(1), WNT5A(7), WNT5B(3), WNT6(1), WNT7A(3), WNT7B(2), WNT8A(2), WNT8B(5), WNT9A(4), WNT9B(2) 37866316 835 177 716 267 274 306 159 11 83 2 0.0164 1.000 1.000 284 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 108 ABL1(8), ANAPC1(21), ANAPC10(2), ANAPC2(6), ANAPC4(5), ANAPC5(8), ANAPC7(5), ATM(54), ATR(38), BUB1(10), BUB1B(6), BUB3(4), CCNA1(5), CCNA2(7), CCNB1(8), CCNB2(5), CCNB3(33), CCND1(14), CCND2(9), CCND3(4), CCNE1(6), CCNE2(8), CCNH(7), CDC14A(6), CDC14B(6), CDC16(12), CDC20(4), CDC23(7), CDC25A(8), CDC25B(3), CDC25C(5), CDC6(3), CDC7(11), CDK2(2), CDK4(3), CDK6(3), CDK7(7), CDKN1A(1), CDKN1B(7), CDKN2A(2), CDKN2C(4), CDKN2D(1), CHEK1(2), CHEK2(14), CREBBP(32), CUL1(13), DBF4(11), E2F1(9), E2F2(3), E2F3(4), EP300(32), ESPL1(11), FZR1(2), GADD45G(1), GSK3B(13), HDAC1(5), HDAC2(5), MAD1L1(12), MAD2L1(4), MAD2L2(2), MCM2(7), MCM3(9), MCM4(11), MCM5(8), MCM6(6), MCM7(6), MDM2(4), PCNA(3), PKMYT1(2), PLK1(4), PRKDC(54), PTTG1(2), PTTG2(1), RB1(26), RBL1(13), RBL2(19), RBX1(1), SKP2(7), SMAD2(9), SMAD3(7), SMAD4(5), SMC1A(19), SMC1B(21), TFDP1(13), TGFB1(2), TGFB2(5), TGFB3(9), TP53(74), WEE1(2), YWHAE(4), YWHAG(3), YWHAH(3), YWHAQ(1), YWHAZ(1) 49263559 904 173 857 223 255 296 183 5 153 12 0.00326 1.000 1.000 285 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY7(9), ADCY8(22), ADCY9(27), ADORA2A(6), ADORA2B(1), ADRA1A(12), ADRA1B(6), ADRA1D(1), ADRB2(7), ADRB3(3), AGTR1(4), ATP2A1(12), ATP2A2(8), ATP2A3(11), ATP2B1(15), ATP2B2(12), ATP2B3(17), ATP2B4(14), AVPR1A(7), AVPR1B(3), BDKRB1(3), BDKRB2(8), BST1(1), CACNA1A(19), CACNA1B(35), CACNA1C(38), CACNA1D(29), CACNA1E(59), CACNA1F(41), CACNA1G(24), CACNA1H(12), CACNA1I(8), CACNA1S(33), CALM1(2), CALM2(4), CALML3(3), CALML6(4), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CAMK4(5), CCKAR(9), CCKBR(3), CD38(6), CHRM1(6), CHRM2(10), CHRM3(8), CHRM5(9), CHRNA7(5), CYSLTR1(8), CYSLTR2(5), DRD1(6), EDNRA(5), EDNRB(4), EGFR(12), ERBB2(10), ERBB3(20), ERBB4(27), F2R(6), GNA11(2), GNA14(7), GNA15(1), GNAL(6), GNAQ(3), GNAS(24), GRIN1(4), GRIN2A(25), GRIN2C(6), GRIN2D(5), GRM1(29), GRM5(27), GRPR(4), HRH1(10), HRH2(4), HTR2A(11), HTR2B(2), HTR2C(17), HTR4(8), HTR5A(12), HTR6(4), HTR7(5), ITPKA(1), ITPKB(11), ITPR1(34), ITPR2(35), ITPR3(21), LHCGR(17), LTB4R2(4), MYLK(14), MYLK2(8), NOS1(18), NOS3(11), NTSR1(5), OXTR(4), P2RX1(5), P2RX2(3), P2RX3(8), P2RX4(1), P2RX5(5), P2RX7(1), PDE1A(15), PDE1B(7), PDE1C(12), PDGFRA(24), PDGFRB(12), PHKA1(20), PHKA2(21), PHKB(15), PHKG1(7), PHKG2(3), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PLCD1(5), PLCD3(3), PLCD4(11), PLCE1(41), PLCG1(12), PLCG2(27), PLCZ1(14), PLN(2), PPID(3), PPP3CA(4), PPP3CB(5), PPP3CC(6), PPP3R1(1), PPP3R2(3), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(10), PRKCG(8), PRKX(2), PTAFR(4), PTGER3(7), PTGFR(13), PTK2B(16), RYR1(72), RYR2(111), RYR3(94), SLC25A4(2), SLC25A5(2), SLC25A6(5), SLC8A1(13), SLC8A2(6), SLC8A3(13), SPHK1(2), SPHK2(2), TACR1(7), TACR2(3), TACR3(9), TNNC1(2), TNNC2(3), TRHR(3), TRPC1(13), VDAC1(2), VDAC2(3), VDAC3(2) 98590383 1955 172 1906 757 676 716 347 15 191 10 0.637 1.000 1.000 286 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 126 ABL1(8), ABLIM1(7), ABLIM2(8), ABLIM3(8), ARHGEF12(29), CDC42(4), CDK5(2), CFL1(1), CFL2(8), CXCL12(6), CXCR4(1), DCC(34), DPYSL2(12), DPYSL5(4), EFNA1(1), EFNA3(1), EFNA4(3), EFNA5(3), EFNB1(6), EFNB2(2), EFNB3(1), EPHA1(11), EPHA2(5), EPHA3(18), EPHA4(19), EPHA5(25), EPHA6(20), EPHA7(9), EPHA8(13), EPHB1(26), EPHB2(12), EPHB3(6), EPHB4(4), EPHB6(11), FES(15), FYN(7), GNAI1(5), GNAI2(6), GNAI3(4), GSK3B(13), HRAS(1), ITGB1(8), KRAS(53), L1CAM(20), LIMK1(8), LIMK2(15), LRRC4C(13), MAPK1(2), MAPK3(3), MET(17), NCK1(4), NCK2(8), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(5), NGEF(16), NRAS(9), NRP1(16), NTN1(3), NTN4(5), NTNG1(8), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PAK7(9), PLXNA1(24), PLXNA2(25), PLXNA3(18), PLXNB1(14), PLXNB2(16), PLXNB3(23), PLXNC1(26), PPP3CA(4), PPP3CB(5), PPP3CC(6), PPP3R1(1), PPP3R2(3), PTK2(12), RAC1(1), RAC2(3), RASA1(30), RGS3(11), RHOA(3), RHOD(1), RND1(6), ROBO1(24), ROBO2(24), ROBO3(16), ROCK1(22), ROCK2(17), SEMA3A(8), SEMA3B(6), SEMA3C(11), SEMA3D(12), SEMA3E(9), SEMA3F(6), SEMA3G(5), SEMA4A(8), SEMA4B(4), SEMA4C(7), SEMA4D(6), SEMA4F(11), SEMA4G(4), SEMA5A(19), SEMA5B(8), SEMA6A(9), SEMA6B(3), SEMA6C(5), SEMA6D(26), SEMA7A(11), SLIT1(14), SLIT2(29), SLIT3(20), SRGAP1(17), SRGAP2(14), SRGAP3(11), UNC5A(9), UNC5B(8), UNC5C(10), UNC5D(15) 69179806 1339 163 1259 451 427 489 238 8 171 6 0.148 1.000 1.000 287 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 233 ADCYAP1R1(5), ADORA1(3), ADORA2A(6), ADORA2B(1), ADORA3(5), ADRA1A(12), ADRA1B(6), ADRA2A(6), ADRA2B(5), ADRA2C(2), ADRB2(7), ADRB3(3), AGTR1(4), AGTR2(11), AVPR1A(7), AVPR1B(3), AVPR2(5), BDKRB1(3), BDKRB2(8), BRS3(17), C3AR1(9), C5AR1(3), CALCR(9), CALCRL(8), CCKAR(9), CCKBR(3), CGA(1), CHRM1(6), CHRM2(10), CHRM3(8), CHRM4(9), CHRM5(9), CNR1(12), CNR2(6), CRHR1(3), CRHR2(2), CTSG(3), CYSLTR1(8), CYSLTR2(5), DRD1(6), DRD2(8), DRD3(6), DRD5(11), EDNRA(5), EDNRB(4), F2(8), F2R(6), F2RL1(4), F2RL2(2), FPR1(2), FSHR(16), GABBR1(12), GABBR2(15), GABRA1(14), GABRA2(13), GABRA3(14), GABRA4(19), GABRA5(10), GABRA6(7), GABRB1(9), GABRB2(15), GABRB3(10), GABRD(6), GABRE(7), GABRG1(10), GABRG2(16), GABRG3(9), GABRP(5), GABRQ(11), GABRR1(3), GALR1(3), GALR3(2), GH1(3), GH2(3), GHR(8), GHRHR(2), GHSR(8), GIPR(5), GLP1R(5), GLP2R(11), GLRA1(8), GLRA2(8), GLRA3(9), GLRB(7), GNRHR(4), GPR156(7), GPR35(3), GPR50(8), GPR63(5), GPR83(3), GRIA1(13), GRIA2(20), GRIA3(22), GRIA4(19), GRID1(13), GRID2(16), GRIK1(17), GRIK2(12), GRIK3(16), GRIK4(7), GRIK5(18), GRIN1(4), GRIN2A(25), GRIN2B(25), GRIN2C(6), GRIN2D(5), GRIN3A(15), GRIN3B(3), GRM1(29), GRM2(9), GRM3(19), GRM4(12), GRM5(27), GRM6(15), GRM7(20), GRM8(19), GRPR(4), GZMA(6), HCRTR2(11), HRH1(10), HRH2(4), HRH3(2), HRH4(5), HTR1A(14), HTR1B(6), HTR1D(6), HTR1E(11), HTR1F(11), HTR2A(11), HTR2B(2), HTR2C(17), HTR4(8), HTR5A(12), HTR6(4), HTR7(5), LEP(2), LEPR(12), LHB(2), LHCGR(17), LTB4R(2), LTB4R2(4), MAS1(3), MC1R(3), MC2R(4), MC3R(5), MC4R(5), MC5R(14), MCHR1(8), MCHR2(3), MLNR(5), MTNR1A(5), MTNR1B(4), NMBR(4), NMUR1(4), NMUR2(8), NPBWR2(1), NPFFR1(1), NPFFR2(13), NPY1R(9), NPY2R(5), NPY5R(13), NR3C1(18), NTSR1(5), NTSR2(1), OPRD1(1), OPRK1(10), OPRL1(3), OPRM1(13), OXTR(4), P2RX1(5), P2RX2(3), P2RX3(8), P2RX4(1), P2RX5(5), P2RX7(1), P2RY1(3), P2RY10(8), P2RY11(7), P2RY13(2), P2RY14(6), P2RY2(3), P2RY4(5), P2RY6(4), P2RY8(7), PARD3(19), PPYR1(8), PRL(6), PRLHR(1), PRLR(5), PRSS1(4), PRSS3(2), PTAFR(4), PTGDR(9), PTGER2(3), PTGER3(7), PTGER4(12), PTGFR(13), PTGIR(3), PTH2R(12), RXFP1(22), RXFP2(14), SCTR(5), SSTR1(10), SSTR2(3), SSTR3(3), SSTR4(10), SSTR5(2), TAAR1(7), TAAR2(7), TAAR5(5), TAAR6(6), TAAR8(3), TAAR9(8), TACR1(7), TACR2(3), TACR3(9), THRA(6), THRB(4), TRHR(3), TRPV1(3), TSHB(3), TSHR(8), TSPO(2), VIPR1(3), VIPR2(4) 77867473 1739 162 1683 650 538 752 283 19 142 5 0.102 1.000 1.000 288 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(5), ACTB(3), ACTG1(6), ACTN1(9), ACTN2(16), ACTN3(10), ACTN4(8), ACVR1B(9), ACVR1C(6), BAIAP2(5), CDC42(4), CDH1(14), CREBBP(32), CSNK2A1(9), CSNK2A2(4), CTNNA1(18), CTNNA2(16), CTNNA3(13), CTNNB1(80), CTNND1(27), EGFR(12), EP300(32), ERBB2(10), FARP2(15), FER(14), FGFR1(10), FYN(7), IGF1R(13), INSR(18), IQGAP1(12), LEF1(9), LMO7(26), MAP3K7(9), MAPK1(2), MAPK3(3), MET(17), MLLT4(21), NLK(5), PARD3(19), PTPN1(5), PTPN6(6), PTPRB(31), PTPRF(27), PTPRJ(18), PTPRM(15), PVRL1(10), PVRL2(5), PVRL3(7), PVRL4(4), RAC1(1), RAC2(3), RHOA(3), SMAD2(9), SMAD3(7), SMAD4(5), SNAI1(2), SNAI2(5), SORBS1(18), SRC(3), SSX2IP(11), TCF7(3), TCF7L1(4), TCF7L2(11), TGFBR1(5), TGFBR2(6), TJP1(24), VCL(11), WAS(11), WASF1(3), WASF2(3), WASF3(8), WASL(8), YES1(8) 43898605 848 162 771 222 254 303 169 10 105 7 0.000362 1.000 1.000 289 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(8), ATM(54), BUB1(10), BUB1B(6), BUB3(4), CCNA1(5), CCNA2(7), CCNB1(8), CCNB2(5), CCNB3(33), CCND2(9), CCND3(4), CCNE1(6), CCNE2(8), CCNH(7), CDAN1(9), CDC14A(6), CDC14B(6), CDC20(4), CDC25A(8), CDC25B(3), CDC25C(5), CDC6(3), CDC7(11), CDH1(14), CDK2(2), CDK4(3), CDKN1A(1), CDKN2A(2), CHEK1(2), CHEK2(14), DTX4(4), E2F1(9), E2F2(3), E2F3(4), E2F4(3), E2F5(6), E2F6(1), EP300(32), ESPL1(11), GSK3B(13), HDAC1(5), HDAC2(5), HDAC3(12), HDAC4(14), HDAC5(12), HDAC6(25), HDAC8(2), MAD1L1(12), MAD2L1(4), MAD2L2(2), MCM2(7), MCM3(9), MCM4(11), MCM5(8), MCM6(6), MCM7(6), MDM2(4), MPEG1(9), MPL(7), PCNA(3), PLK1(4), PRKDC(54), PTPRA(10), PTTG1(2), PTTG2(1), RB1(26), RBL1(13), SKP2(7), SMAD4(5), TBC1D8(15), TFDP1(13), TGFB1(2), TP53(74), WEE1(2) 40838039 744 158 702 197 223 243 142 5 122 9 0.0151 1.000 1.000 290 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), ADRA1A(12), ADRA1B(6), ADRA1D(1), ADRB2(7), ADRB3(3), ANXA6(11), ARRB1(4), ARRB2(4), ATP1A4(24), ATP1B1(6), ATP1B2(5), ATP1B3(3), ATP2A2(8), ATP2A3(11), ATP2B1(15), ATP2B2(12), ATP2B3(17), CACNA1A(19), CACNA1B(35), CACNA1C(38), CACNA1D(29), CACNA1E(59), CACNA1S(33), CACNB1(12), CACNB3(5), CALM1(2), CALM2(4), CALR(3), CAMK1(2), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CAMK4(5), CASQ1(7), CASQ2(9), CHRM1(6), CHRM2(10), CHRM3(8), CHRM4(9), CHRM5(9), FXYD2(3), GJA1(5), GJA4(1), GJA5(6), GJB1(3), GJB2(3), GJB3(4), GJB4(6), GJB5(2), GJB6(3), GNA11(2), GNAI2(6), GNAI3(4), GNAO1(7), GNAQ(3), GNAZ(4), GNB1(2), GNB2(5), GNB3(2), GNB4(4), GNB5(3), GNG12(1), GNG13(2), GNG2(2), GNG3(2), GNG4(5), GNG7(1), GNGT1(1), GRK4(10), GRK5(10), GRK6(2), ITPR1(34), ITPR2(35), ITPR3(21), KCNB1(13), KCNJ3(9), KCNJ5(7), MIB1(9), MYCBP(2), NME7(4), PEA15(2), PKIA(1), PLCB3(11), PLN(2), PRKACA(6), PRKACB(3), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(10), PRKCD(5), PRKCE(10), PRKCG(8), PRKCH(10), PRKCQ(9), PRKCZ(3), PRKD1(8), RGS1(6), RGS10(2), RGS11(1), RGS14(4), RGS16(5), RGS17(4), RGS18(3), RGS19(3), RGS2(3), RGS20(2), RGS3(11), RGS4(8), RGS5(4), RGS6(11), RGS7(9), RGS9(11), RYR1(72), RYR2(111), RYR3(94), SLC8A1(13), SLC8A3(13), USP5(13), YWHAH(3), YWHAQ(1) 69521324 1384 154 1354 523 488 514 222 11 140 9 0.391 1.000 1.000 291 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(12), BRAF(10), CACNA1A(19), CRH(1), CRHR1(3), GNA11(2), GNA12(8), GNA13(7), GNAI1(5), GNAI2(6), GNAI3(4), GNAO1(7), GNAQ(3), GNAS(24), GNAZ(4), GRIA1(13), GRIA2(20), GRIA3(22), GRID2(16), GRM1(29), GRM5(27), GUCY1A2(10), GUCY1A3(11), GUCY1B3(8), GUCY2C(14), GUCY2D(7), GUCY2F(26), HRAS(1), IGF1(5), IGF1R(13), ITPR1(34), ITPR2(35), ITPR3(21), KRAS(53), LYN(9), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), NOS1(18), NOS3(11), NPR1(12), NPR2(11), NRAS(9), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PPP2CA(6), PPP2CB(4), PPP2R1A(30), PPP2R1B(6), PPP2R2A(10), PPP2R2B(12), PPP2R2C(2), PRKCA(10), PRKCG(8), PRKG1(11), PRKG2(11), RAF1(8), RYR1(72) 40168024 840 149 763 271 256 356 134 9 82 3 0.0631 1.000 1.000 292 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 135 ACTB(3), ACTG1(6), CHAD(3), COL11A1(37), COL11A2(10), COL17A1(20), COL1A1(12), COL1A2(24), COL2A1(15), COL3A1(19), COL4A1(21), COL4A2(12), COL4A4(23), COL4A6(32), COL5A1(29), COL5A2(21), COL5A3(19), COL6A1(5), COL6A2(14), COL6A3(44), COL6A6(27), COMP(6), DES(6), DSC1(18), DSC2(14), DSC3(20), DSG1(24), DSG2(15), DSG3(23), DSG4(16), FN1(43), GJA1(5), GJA10(10), GJA3(5), GJA4(1), GJA5(6), GJA8(6), GJA9(15), GJB1(3), GJB2(3), GJB3(4), GJB4(6), GJB5(2), GJB6(3), GJB7(8), GJC1(2), GJC3(2), GJD2(8), GJD4(3), IBSP(7), INA(4), ITGA6(12), ITGB4(8), KRT1(8), KRT10(3), KRT12(8), KRT13(6), KRT14(9), KRT15(10), KRT16(8), KRT17(4), KRT18(1), KRT19(6), KRT2(7), KRT20(4), KRT23(11), KRT24(5), KRT25(7), KRT27(4), KRT28(4), KRT3(9), KRT31(8), KRT32(10), KRT33A(7), KRT33B(5), KRT34(8), KRT35(9), KRT36(6), KRT37(8), KRT38(8), KRT39(14), KRT4(9), KRT40(5), KRT5(6), KRT6A(4), KRT6B(9), KRT6C(8), KRT7(3), KRT71(5), KRT72(6), KRT73(7), KRT74(1), KRT75(4), KRT76(6), KRT77(7), KRT78(5), KRT79(5), KRT8(7), KRT81(4), KRT82(1), KRT83(3), KRT84(7), KRT85(6), KRT86(1), KRT9(8), LAMA1(30), LAMA2(61), LAMA3(30), LAMA4(15), LAMA5(17), LAMB1(23), LAMB2(26), LAMB3(16), LAMB4(32), LAMC1(18), LAMC2(17), LAMC3(17), LMNA(7), LMNB1(5), LMNB2(4), NES(28), RELN(48), SPP1(2), THBS1(11), THBS2(20), THBS3(3), THBS4(12), TNC(26), TNN(19), TNR(14), TNXB(19), VIM(8), VTN(3), VWF(25) 88632952 1584 147 1551 525 484 632 260 19 174 15 0.0743 1.000 1.000 293 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), ATF4(3), CACNA1C(38), CACNA1D(29), CACNA1F(41), CACNA1S(33), CALM1(2), CALM2(4), CALML3(3), CALML6(4), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CDC42(4), CGA(1), EGFR(12), ELK1(3), GNA11(2), GNAQ(3), GNAS(24), GNRH1(1), GNRH2(1), GNRHR(4), GRB2(3), HBEGF(2), HRAS(1), ITPR1(34), ITPR2(35), ITPR3(21), JUN(1), KRAS(53), LHB(2), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP2K7(4), MAP3K1(30), MAP3K2(12), MAP3K3(9), MAP3K4(21), MAPK1(2), MAPK10(9), MAPK11(3), MAPK12(3), MAPK13(4), MAPK14(4), MAPK3(3), MAPK7(14), MAPK8(10), MAPK9(5), MMP14(6), MMP2(7), NRAS(9), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PLD1(14), PLD2(10), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(10), PRKCD(5), PRKX(2), PTK2B(16), RAF1(8), SOS1(13), SOS2(17), SRC(3) 46763646 929 142 859 284 321 333 151 13 104 7 0.00479 1.000 1.000 294 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(56), AXIN1(9), CCND1(14), CCND2(9), CCND3(4), CSNK1E(3), CTNNB1(80), DVL1(3), DVL2(10), DVL3(9), FBXW2(4), FOSL1(3), FZD1(3), FZD10(9), FZD2(8), FZD3(9), FZD5(2), FZD6(13), FZD7(4), FZD8(2), FZD9(6), GSK3B(13), JUN(1), LDLR(6), MAPK10(9), MAPK9(5), MYC(8), PAFAH1B1(2), PLAU(6), PPP2R5C(7), PPP2R5E(8), PRKCA(10), PRKCD(5), PRKCE(10), PRKCG(8), PRKCH(10), PRKCI(6), PRKCQ(9), PRKCZ(3), PRKD1(8), RAC1(1), RHOA(3), SFRP4(9), TCF7(3), WNT1(1), WNT10A(2), WNT10B(2), WNT11(6), WNT16(7), WNT2(3), WNT2B(6), WNT3(3), WNT4(1), WNT5A(7), WNT5B(3), WNT6(1), WNT7A(3), WNT7B(2) 20506676 457 141 388 145 136 176 87 4 50 4 0.0971 1.000 1.000 295 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(11), CD36(8), CD44(5), CD47(6), CHAD(3), COL11A1(37), COL11A2(10), COL1A1(12), COL1A2(24), COL2A1(15), COL3A1(19), COL4A1(21), COL4A2(12), COL4A4(23), COL4A6(32), COL5A1(29), COL5A2(21), COL5A3(19), COL6A1(5), COL6A2(14), COL6A3(44), COL6A6(27), DAG1(6), FN1(43), FNDC1(34), FNDC3A(7), FNDC4(3), FNDC5(2), GP5(3), GP6(5), GP9(1), HMMR(12), HSPG2(24), IBSP(7), ITGA1(17), ITGA10(9), ITGA11(7), ITGA2(19), ITGA2B(10), ITGA3(7), ITGA4(10), ITGA5(10), ITGA6(12), ITGA7(14), ITGA8(20), ITGA9(16), ITGAV(10), ITGB1(8), ITGB3(11), ITGB4(8), ITGB5(8), ITGB6(7), ITGB7(4), ITGB8(9), LAMA1(30), LAMA2(61), LAMA3(30), LAMA4(15), LAMA5(17), LAMB1(23), LAMB2(26), LAMB3(16), LAMB4(32), LAMC1(18), LAMC2(17), LAMC3(17), RELN(48), SDC1(1), SDC2(1), SDC3(2), SDC4(4), SPP1(2), SV2A(14), SV2B(13), SV2C(17), THBS1(11), THBS2(20), THBS3(3), THBS4(12), TNC(26), TNN(19), TNR(14), TNXB(19), VTN(3), VWF(25) 79695637 1316 139 1289 455 393 528 212 15 153 15 0.322 1.000 1.000 296 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 56 ALG2(2), BAK1(3), BAX(3), BFAR(7), BTK(12), CAD(25), CASP10(8), CASP3(4), CASP8(21), CD7(3), CDK2AP1(1), CSNK1A1(4), DAXX(10), DEDD(2), DEDD2(2), DIABLO(2), EGFR(12), EPHB2(12), FADD(1), FAF1(10), FAIM2(3), IL8(3), MAP2K4(9), MAP2K7(4), MAP3K1(30), MAP3K5(25), MAPK1(2), MAPK10(9), MAPK8(10), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(9), MAPK9(5), MET(17), NFAT5(16), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NFKBIL1(2), NR0B2(2), PFN1(1), PFN2(2), PTPN13(30), RALBP1(6), RIPK1(9), ROCK1(22), SMPD1(11), TP53(74), TPX2(12), TRAF2(3), TUFM(5) 24662302 499 137 464 126 136 182 82 2 92 5 0.00658 1.000 1.000 297 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 136 ACTA1(5), ACTA2(7), ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), ADM(2), ARRB1(4), ARRB2(4), ATF1(6), ATF2(8), ATF3(3), ATF4(3), ATF5(6), ATP2A2(8), ATP2A3(11), CACNB3(5), CALCA(2), CALM1(2), CALM2(4), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CNN1(3), CNN2(1), CORIN(13), CRH(1), CRHR1(3), DGKZ(10), ETS2(6), FOS(3), GABPA(8), GABPB2(12), GBA2(13), GJA1(5), GNAQ(3), GNB1(2), GNB2(5), GNB3(2), GNB4(4), GNB5(3), GNG12(1), GNG13(2), GNG2(2), GNG3(2), GNG4(5), GNG7(1), GNGT1(1), GRK4(10), GRK5(10), GRK6(2), GSTO1(3), GUCA2B(1), GUCY1A3(11), IGFBP1(4), IGFBP2(5), IGFBP3(4), IGFBP4(3), IGFBP6(2), IL1B(2), IL6(5), ITPR1(34), ITPR2(35), ITPR3(21), JUN(1), MIB1(9), MYL2(2), MYLK2(8), NFKB1(10), NOS1(18), NOS3(11), OXTR(4), PDE4B(14), PDE4D(9), PKIA(1), PLCB3(11), PLCD1(5), PLCG1(12), PLCG2(27), PRKACA(6), PRKACB(3), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(10), PRKCD(5), PRKCE(10), PRKCH(10), PRKCQ(9), PRKCZ(3), PRKD1(8), RAMP1(1), RAMP3(2), RGS1(6), RGS10(2), RGS11(1), RGS14(4), RGS16(5), RGS17(4), RGS18(3), RGS19(3), RGS2(3), RGS20(2), RGS3(11), RGS4(8), RGS5(4), RGS6(11), RGS7(9), RGS9(11), RLN1(1), RYR1(72), RYR2(111), RYR3(94), SLC8A1(13), SP1(7), TNXB(19), USP5(13), YWHAH(3), YWHAQ(1) 62417276 1161 136 1132 436 385 439 203 7 120 7 0.595 1.000 1.000 298 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), AKAP1(9), AKAP10(9), AKAP11(23), AKAP12(21), AKAP3(21), AKAP4(15), AKAP5(3), AKAP6(34), AKAP7(7), AKAP8(5), AKAP9(53), ARHGEF1(12), CALM1(2), CALM2(4), CHMP1B(1), GNA11(2), GNA12(8), GNA13(7), GNA14(7), GNA15(1), GNAI2(6), GNAI3(4), GNAL(6), GNAO1(7), GNAQ(3), GNAZ(4), GNB1(2), GNB2(5), GNB3(2), GNB5(3), GNG12(1), GNG13(2), GNG3(2), GNG4(5), GNG7(1), GNGT1(1), GNGT2(3), HRAS(1), IL18BP(1), ITPR1(34), KCNJ3(9), KRAS(53), NRAS(9), PALM2(7), PDE1A(15), PDE1B(7), PDE1C(12), PDE4A(10), PDE4B(14), PDE4C(2), PDE4D(9), PDE7A(1), PDE7B(7), PDE8A(7), PDE8B(19), PLCB3(11), PPP3CA(4), PPP3CC(6), PRKACA(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(10), PRKCD(5), PRKCE(10), PRKCG(8), PRKCH(10), PRKCI(6), PRKCQ(9), PRKCZ(3), PRKD1(8), PRKD3(11), RHOA(3), RRAS(3), SLC9A1(8), USP5(13) 42506319 830 133 768 302 259 294 173 6 94 4 0.602 1.000 1.000 299 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 246 ACVR1(8), ACVR1B(9), ACVR2A(7), ACVR2B(5), AMHR2(3), BMP2(6), BMP7(12), BMPR1A(5), BMPR1B(6), BMPR2(12), CCL1(1), CCL13(2), CCL14(1), CCL15(1), CCL16(1), CCL17(1), CCL18(1), CCL21(1), CCL23(3), CCL24(3), CCL25(1), CCL28(2), CCL4(5), CCL5(2), CCL7(4), CCL8(3), CCR1(4), CCR2(5), CCR3(4), CCR4(5), CCR5(6), CCR6(5), CCR7(6), CCR8(6), CCR9(4), CD27(4), CD40(4), CD40LG(6), CD70(2), CLCF1(1), CNTF(3), CNTFR(2), CRLF2(5), CSF1(6), CSF1R(8), CSF2(1), CSF2RA(12), CSF2RB(14), CSF3(1), CSF3R(7), CX3CL1(3), CX3CR1(6), CXCL1(3), CXCL10(2), CXCL12(6), CXCL13(2), CXCL16(2), CXCL2(2), CXCL3(1), CXCL5(3), CXCL9(2), CXCR3(5), CXCR4(1), CXCR6(1), EDA(5), EDA2R(6), EDAR(5), EGF(19), EGFR(12), EPO(2), EPOR(4), FAS(9), FASLG(7), FLT1(20), FLT3(16), FLT3LG(2), FLT4(9), GDF5(7), GH1(3), GH2(3), GHR(8), HGF(14), IFNA1(2), IFNA10(3), IFNA13(3), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(2), IFNA21(1), IFNA4(3), IFNA5(5), IFNA6(2), IFNA7(1), IFNA8(3), IFNAR1(7), IFNAR2(8), IFNB1(3), IFNG(9), IFNGR1(4), IFNGR2(4), IFNK(2), IFNW1(3), IL10(3), IL10RA(4), IL10RB(6), IL11(2), IL11RA(5), IL12A(5), IL12B(2), IL12RB1(13), IL12RB2(10), IL13RA1(13), IL15(2), IL17RA(5), IL17RB(5), IL18(2), IL18R1(9), IL18RAP(15), IL19(2), IL1B(2), IL1R1(5), IL1R2(5), IL1RAP(8), IL2(2), IL20(9), IL20RA(3), IL21(3), IL21R(7), IL22RA1(4), IL22RA2(1), IL23A(4), IL23R(5), IL24(7), IL25(2), IL26(3), IL28A(3), IL28B(2), IL28RA(9), IL29(2), IL2RA(4), IL2RB(3), IL2RG(13), IL3(2), IL3RA(9), IL4(1), IL4R(6), IL5(2), IL5RA(9), IL6(5), IL6R(7), IL6ST(11), IL7(1), IL7R(12), IL8(3), IL9(1), IL9R(7), INHBA(7), INHBB(2), INHBC(3), INHBE(6), KDR(26), KIT(24), KITLG(3), LEP(2), LEPR(12), LIF(3), LIFR(27), LTA(3), LTBR(5), MET(17), MPL(7), NGFR(3), OSM(2), OSMR(13), PDGFB(2), PDGFC(3), PDGFRA(24), PDGFRB(12), PF4(1), PF4V1(1), PLEKHO2(6), PPBP(1), PRL(6), PRLR(5), RELT(2), TGFB1(2), TGFB2(5), TGFB3(9), TGFBR1(5), TGFBR2(6), TNFRSF10A(2), TNFRSF10B(5), TNFRSF10C(4), TNFRSF10D(6), TNFRSF11A(4), TNFRSF11B(13), TNFRSF13B(3), TNFRSF14(2), TNFRSF17(1), TNFRSF19(4), TNFRSF1A(4), TNFRSF1B(2), TNFRSF21(5), TNFRSF25(3), TNFRSF8(8), TNFRSF9(2), TNFSF10(1), TNFSF11(7), TNFSF12(4), TNFSF13B(5), TNFSF14(2), TNFSF15(3), TNFSF18(4), TNFSF4(4), TNFSF8(1), TNFSF9(6), TPO(15), TSLP(2), VEGFA(2), VEGFB(2), VEGFC(6), XCL2(2), XCR1(3) 63931396 1168 133 1148 361 301 472 236 6 148 5 0.0259 1.000 1.000 300 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 91 ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), CSNK1D(3), DRD1(6), DRD2(8), EGF(19), EGFR(12), GJA1(5), GJD2(8), GNA11(2), GNAI1(5), GNAI2(6), GNAI3(4), GNAQ(3), GNAS(24), GRB2(3), GRM1(29), GRM5(27), GUCY1A2(10), GUCY1A3(11), GUCY1B3(8), GUCY2C(14), GUCY2D(7), GUCY2F(26), HRAS(1), HTR2A(11), HTR2B(2), HTR2C(17), ITPR1(34), ITPR2(35), ITPR3(21), KRAS(53), MAP2K1(2), MAP2K2(5), MAP2K5(3), MAP3K2(12), MAPK1(2), MAPK3(3), MAPK7(14), NPR1(12), NPR2(11), NRAS(9), PDGFA(3), PDGFB(2), PDGFC(3), PDGFD(8), PDGFRA(24), PDGFRB(12), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(10), PRKCG(8), PRKG1(11), PRKG2(11), PRKX(2), RAF1(8), SOS1(13), SOS2(17), SRC(3), TJP1(24), TUBA1A(9), TUBA1B(3), TUBA1C(5), TUBA3C(5), TUBA3D(4), TUBA3E(10), TUBA4A(11), TUBA8(7), TUBAL3(6), TUBB1(5), TUBB2A(2), TUBB2B(2), TUBB3(6), TUBB6(5), TUBB8(4) 47468487 942 132 874 293 285 362 182 12 98 3 0.0138 1.000 1.000 301 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(21), ADCY8(22), ARAF(12), ATF4(3), BRAF(10), CACNA1C(38), CALM1(2), CALM2(4), CALML3(3), CALML6(4), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CAMK4(5), CREBBP(32), EP300(32), GNAQ(3), GRIA1(13), GRIA2(20), GRIN1(4), GRIN2A(25), GRIN2B(25), GRIN2C(6), GRIN2D(5), GRM1(29), GRM5(27), HRAS(1), ITPR1(34), ITPR2(35), ITPR3(21), KRAS(53), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), NRAS(9), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PPP1CA(3), PPP1CB(9), PPP1CC(4), PPP1R12A(8), PPP1R1A(4), PPP3CA(4), PPP3CB(5), PPP3CC(6), PPP3R1(1), PPP3R2(3), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(10), PRKCG(8), PRKX(2), RAF1(8), RAP1A(4), RAP1B(2), RAPGEF3(10), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), RPS6KA6(19) 36763828 737 132 672 244 222 281 144 7 80 3 0.142 1.000 1.000 302 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 127 ALCAM(7), CADM1(4), CADM3(10), CD2(4), CD22(14), CD226(6), CD274(1), CD276(2), CD28(3), CD34(1), CD4(6), CD40(4), CD40LG(6), CD58(2), CD6(6), CD80(5), CD86(5), CD8A(2), CD8B(1), CD99(1), CDH1(14), CDH15(8), CDH2(19), CDH3(6), CDH4(17), CDH5(6), CLDN1(3), CLDN10(7), CLDN11(2), CLDN15(5), CLDN16(4), CLDN17(4), CLDN18(7), CLDN19(2), CLDN2(3), CLDN20(3), CLDN22(2), CLDN8(4), CLDN9(3), CNTN1(18), CNTN2(6), CNTNAP1(12), CNTNAP2(31), CTLA4(2), ESAM(1), F11R(1), GLG1(8), HLA-A(1), HLA-B(3), HLA-C(2), HLA-DMA(3), HLA-DOA(3), HLA-DOB(3), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(1), HLA-DRB5(1), HLA-E(1), HLA-F(3), HLA-G(2), ICAM1(2), ICAM2(3), ICAM3(3), ICOS(3), ICOSLG(2), ITGA4(10), ITGA6(12), ITGA8(20), ITGA9(16), ITGAL(17), ITGAM(21), ITGAV(10), ITGB1(8), ITGB2(14), ITGB7(4), ITGB8(9), JAM2(9), JAM3(3), L1CAM(20), MADCAM1(2), MAG(7), MPZ(3), MPZL1(3), NCAM1(9), NCAM2(33), NEGR1(7), NEO1(17), NFASC(33), NLGN1(9), NLGN2(7), NLGN3(25), NRCAM(14), NRXN1(36), NRXN2(17), NRXN3(29), OCLN(2), PDCD1(3), PDCD1LG2(1), PTPRC(17), PTPRF(27), PTPRM(15), PVR(3), PVRL1(10), PVRL2(5), PVRL3(7), SDC1(1), SDC2(1), SDC3(2), SDC4(4), SELE(5), SELL(5), SELP(12), SELPLG(9), SIGLEC1(11), SPN(1), VCAM1(12), VCAN(65) 51647538 970 131 941 323 303 376 164 5 113 9 0.0349 1.000 1.000 303 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 141 ADA(2), ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), ADK(2), ADSL(8), ADSS(6), ADSSL1(5), AK1(1), AK2(3), AK5(8), AK7(13), ALLC(8), AMPD1(23), AMPD2(6), AMPD3(7), ATIC(7), CANT1(1), DCK(5), ENPP1(12), ENPP3(18), ENTPD1(3), ENTPD3(5), ENTPD4(2), ENTPD5(2), ENTPD6(10), ENTPD8(5), FHIT(4), GART(9), GDA(4), GMPR(6), GMPR2(3), GMPS(14), GUCY1A2(10), GUCY1A3(11), GUCY1B3(8), GUCY2C(14), GUCY2D(7), GUCY2F(26), GUK1(7), HPRT1(2), IMPDH1(6), IMPDH2(5), ITPA(1), NME1(2), NME4(2), NME6(2), NME7(4), NPR1(12), NPR2(11), NT5C(1), NT5C1A(2), NT5C1B(8), NT5C2(6), NT5C3(8), NT5E(6), NT5M(3), NUDT2(2), NUDT5(2), NUDT9(1), PAICS(4), PAPSS1(8), PAPSS2(7), PDE10A(15), PDE11A(12), PDE1A(15), PDE1C(12), PDE2A(14), PDE3B(15), PDE4A(10), PDE4B(14), PDE4C(2), PDE4D(9), PDE5A(14), PDE6D(2), PDE6G(1), PDE6H(1), PDE7A(1), PDE7B(7), PDE8A(7), PDE8B(19), PDE9A(8), PFAS(11), PKLR(7), PKM2(5), PNPT1(7), POLA1(29), POLA2(3), POLD1(12), POLD2(6), POLD3(6), POLD4(1), POLE(47), POLE2(4), POLE3(3), POLE4(1), POLR1A(16), POLR1B(16), POLR1C(2), POLR1D(3), POLR2A(21), POLR2B(21), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(2), POLR2H(3), POLR2J(1), POLR2K(2), POLR3A(7), POLR3B(14), POLR3G(3), POLR3GL(2), POLR3H(5), PPAT(9), PRIM1(3), PRPS1(3), PRPS1L1(5), PRPS2(7), PRUNE(5), RFC5(8), RRM1(2), RRM2(7), RRM2B(5), XDH(14) 59133569 1056 128 1022 319 334 363 206 12 140 1 0.0276 1.000 1.000 304 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 149 ADORA1(3), ADORA2A(6), ADORA2B(1), ADORA3(5), ADRA1A(12), ADRA1B(6), ADRA1D(1), ADRA2A(6), ADRA2C(2), ADRB2(7), ADRB3(3), AGTR1(4), AGTR2(11), AVPR1A(7), AVPR1B(3), AVPR2(5), BDKRB1(3), BDKRB2(8), BRS3(17), C3AR1(9), CCBP2(3), CCKAR(9), CCKBR(3), CCR1(4), CCR2(5), CCR3(4), CCR4(5), CCR5(6), CCR6(5), CCR7(6), CCR8(6), CCR9(4), CCRL1(7), CCRL2(1), CHML(10), CHRM1(6), CHRM2(10), CHRM3(8), CHRM4(9), CHRM5(9), CMKLR1(9), CNR1(12), CNR2(6), CX3CR1(6), CXCR3(5), CXCR4(1), DRD1(6), DRD2(8), DRD3(6), DRD5(11), EDNRA(5), EDNRB(4), F2R(6), F2RL1(4), F2RL2(2), FPR1(2), FSHR(16), GALR1(3), GALR3(2), GALT(3), GHSR(8), GNB2L1(1), GPR17(6), GPR173(6), GPR174(12), GPR3(5), GPR35(3), GPR37(9), GPR37L1(5), GPR4(9), GPR50(8), GPR6(4), GPR63(5), GPR77(2), GPR83(3), GPR85(7), GPR87(7), GRPR(4), HCRTR2(11), HRH1(10), HRH2(4), HRH3(2), HTR1A(14), HTR1B(6), HTR1D(6), HTR1E(11), HTR1F(11), HTR2A(11), HTR2B(2), HTR2C(17), HTR4(8), HTR5A(12), HTR6(4), HTR7(5), LHCGR(17), LTB4R(2), MAS1(3), MC1R(3), MC3R(5), MC4R(5), MC5R(14), MLNR(5), MTNR1A(5), MTNR1B(4), NMBR(4), NMUR1(4), NMUR2(8), NPY1R(9), NPY2R(5), NPY5R(13), NTSR1(5), NTSR2(1), OPN1SW(6), OPN3(2), OPRD1(1), OPRK1(10), OPRL1(3), OPRM1(13), OXTR(4), P2RY1(3), P2RY10(8), P2RY11(7), P2RY12(5), P2RY13(2), P2RY14(6), P2RY2(3), P2RY6(4), PPYR1(8), PTAFR(4), PTGDR(9), PTGER2(3), PTGER4(12), PTGFR(13), PTGIR(3), RGR(6), RHO(4), RRH(2), SSTR1(10), SSTR2(3), SSTR3(3), SSTR4(10), SUCNR1(3), TRHR(3) 39736749 879 126 854 309 298 360 144 11 66 0 0.00332 1.000 1.000 305 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(4), AKT2(6), AKT3(11), ANKRD6(8), APC(56), AXIN1(9), AXIN2(9), CER1(4), CSNK1A1(4), CTNNB1(80), DACT1(14), DKK1(3), DKK2(3), DKK3(1), DKK4(3), DVL1(3), FSTL1(3), GSK3A(10), GSK3B(13), LRP1(51), MVP(14), NKD1(3), PSEN1(5), PTPRA(10), SENP2(12), SFRP1(6), TSHB(3), WIF1(5) 14398562 353 126 287 95 111 148 53 2 36 3 0.0107 1.000 1.000 306 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(4), ATF2(8), CDC42(4), DLD(5), DUSP10(5), DUSP8(1), GAB1(8), GCK(3), IL1R1(5), JUN(1), MAP2K4(9), MAP2K5(3), MAP2K7(4), MAP3K1(30), MAP3K10(7), MAP3K11(6), MAP3K12(8), MAP3K13(13), MAP3K2(12), MAP3K3(9), MAP3K4(21), MAP3K5(25), MAP3K7(9), MAP3K9(6), MAPK10(9), MAPK7(14), MAPK8(10), MAPK9(5), MYEF2(6), NFATC3(12), NR2C2(7), PAPPA(27), SHC1(7), TP53(74), TRAF6(7), ZAK(15) 17971185 399 123 371 98 128 136 67 4 61 3 0.0186 1.000 1.000 307 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 56 ASH1L(42), ASH2L(12), CARM1(5), CTCFL(13), DOT1L(8), EED(12), EHMT1(23), EHMT2(2), EZH1(10), EZH2(15), FBXO11(8), HCFC1(26), HSF4(3), JMJD4(4), JMJD6(5), KDM6A(14), MEN1(9), MLL(32), MLL2(57), MLL3(56), MLL4(53), MLL5(25), NSD1(37), OGT(17), PAXIP1(10), PPP1CA(3), PPP1CB(9), PPP1CC(4), PRDM2(19), PRDM6(6), PRDM7(2), PRDM9(31), PRMT1(4), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), RBBP5(7), SATB1(18), SETD1A(12), SETD1B(17), SETD2(36), SETD7(7), SETD8(3), SETDB1(16), SETDB2(14), SETMAR(6), SMYD3(6), STK38(9), SUV39H1(9), SUV39H2(5), SUV420H1(16), SUZ12(12), WHSC1(19), WHSC1L1(17) 44102583 832 121 807 235 258 274 160 10 124 6 0.0498 1.000 1.000 308 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 86 ACVR1(8), ACVR1B(9), ACVR1C(6), ACVR2A(7), ACVR2B(5), ACVRL1(2), AMHR2(3), BMP2(6), BMP4(10), BMP5(14), BMP6(5), BMP7(12), BMP8A(3), BMP8B(1), BMPR1A(5), BMPR1B(6), BMPR2(12), CHRD(11), COMP(6), CREBBP(32), CUL1(13), DCN(11), E2F4(3), E2F5(6), EP300(32), FST(4), GDF5(7), GDF6(4), ID1(2), ID2(1), IFNG(9), INHBA(7), INHBB(2), INHBC(3), INHBE(6), LEFTY1(4), LEFTY2(1), LTBP1(17), MAPK1(2), MAPK3(3), MYC(8), NODAL(3), NOG(2), PITX2(12), PPP2CA(6), PPP2CB(4), PPP2R1A(30), PPP2R1B(6), PPP2R2A(10), PPP2R2B(12), PPP2R2C(2), RBL1(13), RBL2(19), RBX1(1), RHOA(3), ROCK1(22), ROCK2(17), RPS6KB1(5), RPS6KB2(4), SMAD1(2), SMAD2(9), SMAD3(7), SMAD4(5), SMAD5(11), SMAD7(3), SMAD9(2), SMURF1(12), SMURF2(7), SP1(7), TFDP1(13), TGFB1(2), TGFB2(5), TGFB3(9), TGFBR1(5), TGFBR2(6), THBS1(11), THBS2(20), THBS3(3), THBS4(12), ZFYVE16(18), ZFYVE9(18) 35156888 666 121 634 186 231 222 123 4 82 4 0.0178 1.000 1.000 309 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(5), ACTA2(7), ACTN2(16), ACTN3(10), ACTN4(8), DES(6), DMD(92), FAM48A(5), MYBPC1(16), MYBPC2(13), MYBPC3(13), MYH3(30), MYH6(16), MYH7(35), MYH8(29), MYL1(5), MYL2(2), MYL3(1), MYL9(3), MYOM1(36), NEB(122), TMOD1(4), TNNC2(3), TNNI1(1), TNNI2(4), TNNI3(4), TNNT1(4), TNNT2(8), TNNT3(4), TPM1(3), TPM2(1), TPM3(5), TPM4(4), TTN(525), VIM(8) 52150257 1048 121 1013 333 292 436 227 4 60 29 0.556 1.000 1.000 310 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(2), ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADK(2), ADSL(8), ADSS(6), AK1(1), AK2(3), AK5(8), ALLC(8), AMPD1(23), AMPD2(6), AMPD3(7), ATIC(7), ATP1B1(6), ATP5A1(8), ATP5B(5), ATP5C1(1), ATP5D(1), ATP5F1(4), ATP5G1(3), ATP5G2(1), ATP5G3(1), ATP5H(1), ATP5I(2), ATP5J(3), CANT1(1), DCK(5), ENPP1(12), ENPP3(18), ENTPD1(3), FHIT(4), GART(9), GDA(4), GMPS(14), GUCY1A2(10), GUCY1A3(11), GUCY1B3(8), GUCY2C(14), GUCY2D(7), GUCY2F(26), GUK1(7), HPRT1(2), IMPDH1(6), IMPDH2(5), ITPA(1), NME1(2), NPR1(12), NPR2(11), NT5C(1), NT5E(6), NT5M(3), NUDT2(2), PAICS(4), PAPSS1(8), PAPSS2(7), PDE1A(15), PDE4A(10), PDE4B(14), PDE4C(2), PDE4D(9), PDE5A(14), PDE6B(5), PDE6C(13), PDE6G(1), PDE7B(7), PDE8A(7), PDE9A(8), PFAS(11), PKLR(7), PKM2(5), POLB(4), POLD1(12), POLD2(6), POLE(47), POLG(6), POLL(7), POLQ(29), POLR1B(16), POLR2A(21), POLR2B(21), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(2), POLR2H(3), POLR2J(1), POLR2K(2), POLRMT(11), PPAT(9), PRPS1(3), PRPS1L1(5), PRPS2(7), PRUNE(5), RRM1(2), RRM2(7) 46086103 827 116 802 257 264 303 154 6 99 1 0.111 1.000 1.000 311 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(4), AKT3(11), BCAR1(8), CAPN1(5), CAPN10(9), CAPN11(9), CAPN2(11), CAPN3(11), CAPN5(9), CAPN6(13), CAPN7(8), CAPN9(11), CAPNS1(2), CAV1(2), CAV2(1), CDC42(4), CRK(2), CSK(1), DOCK1(22), FYN(7), GIT2(9), GRB2(3), ILK(5), ITGA10(9), ITGA11(7), ITGA2(19), ITGA2B(10), ITGA3(7), ITGA4(10), ITGA5(10), ITGA6(12), ITGA7(14), ITGA8(20), ITGA9(16), ITGAD(10), ITGAE(9), ITGAL(17), ITGAM(21), ITGAV(10), ITGAX(14), ITGB1(8), ITGB2(14), ITGB3(11), ITGB4(8), ITGB5(8), ITGB6(7), ITGB7(4), ITGB8(9), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K6(10), MAPK10(9), MAPK12(3), MAPK4(4), MAPK6(11), MAPK7(14), MYLK2(8), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PDPK1(3), PIK3R2(7), PTK2(12), PXN(6), RAC1(1), RAC2(3), RAP1B(2), RAPGEF1(11), RHO(4), ROCK1(22), ROCK2(17), SDCCAG8(13), SEPP1(3), SHC1(7), SHC3(15), SORBS1(18), SOS1(13), SRC(3), TLN1(23), TNS1(19), VASP(3), VAV2(7), VAV3(14), VCL(11), ZYX(11) 48776737 799 114 777 290 255 298 140 6 94 6 0.605 1.000 1.000 312 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 91 CD2BP2(2), CDC40(9), CLK2(9), CLK3(6), CLK4(6), COL2A1(15), CPSF1(11), CPSF2(14), CPSF3(8), CPSF4(1), CSTF1(4), CSTF2(13), CSTF2T(5), CSTF3(10), DDIT3(2), DDX1(5), DDX20(4), DHX15(9), DHX16(11), DHX38(10), DHX8(9), DHX9(14), DICER1(36), DNAJC8(1), FUS(3), GIPC1(2), METTL3(6), NCBP1(9), NCBP2(4), NONO(17), NXF1(4), PABPN1(3), PAPOLA(13), PHF5A(1), POLR2A(21), PPM1G(8), PRPF18(5), PRPF3(10), PRPF4(5), PRPF4B(17), PRPF8(26), PSKH1(8), PTBP1(3), PTBP2(9), RBM17(4), RBM5(5), RNGTT(11), RNMT(7), RNPS1(3), SF3A1(4), SF3A2(2), SF3A3(8), SF3B1(17), SF3B2(9), SF3B4(4), SF3B5(2), SNRPA(2), SNRPB(2), SNRPB2(1), SNRPD1(1), SNRPD2(1), SNRPD3(3), SNRPE(1), SNRPG(1), SNRPN(4), SNURF(1), SPOP(23), SRPK1(11), SRPK2(6), SRRM1(12), SUPT5H(19), U2AF1(4), U2AF2(7), XRN2(19) 38070878 582 111 559 174 200 191 121 3 65 2 0.571 1.000 1.000 313 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(30), ABCA10(27), ABCA12(54), ABCA13(80), ABCA2(10), ABCA3(12), ABCA4(27), ABCA5(30), ABCA6(24), ABCA7(17), ABCA8(27), ABCA9(28), ABCB1(32), ABCB10(10), ABCB11(15), ABCB4(28), ABCB5(32), ABCB6(11), ABCB7(17), ABCB8(6), ABCB9(7), ABCC1(14), ABCC10(10), ABCC11(27), ABCC12(20), ABCC2(30), ABCC3(13), ABCC4(16), ABCC5(15), ABCC6(13), ABCC8(21), ABCC9(29), ABCD1(12), ABCD2(7), ABCD3(9), ABCD4(2), ABCG1(12), ABCG2(16), ABCG4(7), ABCG5(5), ABCG8(7), CFTR(14), TAP1(8), TAP2(1) 42524165 832 108 805 227 229 334 149 3 107 10 8.78e-05 1.000 1.000 314 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 12 ACTN1(9), ACTN2(16), ACTN3(10), BCAR1(8), CSK(1), CTNNA1(18), CTNNA2(16), CTNNB1(80), PTK2(12), PXN(6), SRC(3), VCL(11) 6836403 190 100 131 52 42 93 31 2 21 1 0.0833 1.000 1.000 315 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(17), AMY2A(4), AMY2B(11), ASCC3(31), ATP13A2(5), DDX18(12), DDX19A(4), DDX23(9), DDX4(15), DDX41(3), DDX47(5), DDX50(10), DDX51(8), DDX52(4), DDX54(8), DDX55(7), DDX56(5), DHX58(6), ENPP1(12), ENPP3(18), ENTPD7(8), EP400(42), ERCC2(1), ERCC3(11), G6PC(5), G6PC2(11), GAA(4), GANC(15), GBA(4), GBA3(9), GBE1(9), GCK(3), GPI(7), GUSB(5), GYS1(13), GYS2(16), HK1(11), HK2(9), HK3(10), IFIH1(5), LYZL1(4), MGAM(51), MOV10L1(19), NUDT5(2), NUDT8(1), PGM1(7), PGM3(4), PYGB(11), PYGL(8), PYGM(10), RAD54B(14), RAD54L(5), RUVBL2(4), SETX(33), SI(65), SKIV2L2(17), SMARCA2(24), SMARCA5(19), TREH(2), UGDH(2), UGP2(6), UGT1A1(6), UGT1A10(7), UGT1A3(2), UGT1A4(5), UGT1A5(7), UGT1A6(3), UGT1A7(7), UGT1A8(5), UGT1A9(3), UGT2A1(11), UGT2A3(5), UGT2B10(18), UGT2B11(18), UGT2B15(9), UGT2B17(7), UGT2B28(21), UGT2B4(11), UGT2B7(5), UXS1(5) 45031394 855 100 827 213 232 307 201 9 100 6 0.000579 1.000 1.000 316 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 83 ATF2(8), BRAF(10), CHUK(8), CREB1(6), DAXX(10), ELK1(3), FOS(3), GRB2(3), HRAS(1), IKBKB(13), JUN(1), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K4(9), MAP2K5(3), MAP2K6(10), MAP2K7(4), MAP3K1(30), MAP3K10(7), MAP3K11(6), MAP3K12(8), MAP3K13(13), MAP3K14(6), MAP3K2(12), MAP3K3(9), MAP3K4(21), MAP3K5(25), MAP3K6(7), MAP3K7(9), MAP3K8(10), MAP3K9(6), MAP4K1(11), MAP4K2(7), MAP4K3(16), MAP4K4(11), MAP4K5(7), MAPK1(2), MAPK10(9), MAPK11(3), MAPK12(3), MAPK13(4), MAPK14(4), MAPK3(3), MAPK4(4), MAPK6(11), MAPK7(14), MAPK8(10), MAPK9(5), MAPKAPK2(6), MAPKAPK3(5), MAPKAPK5(5), MAX(12), MEF2A(3), MEF2B(1), MEF2C(11), MEF2D(7), MKNK1(3), MKNK2(3), MYC(8), NFKB1(10), NFKBIA(3), PAK1(3), PAK2(3), RAC1(1), RAF1(8), RELA(6), RIPK1(9), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), RPS6KA4(2), RPS6KA5(11), RPS6KB1(5), RPS6KB2(4), SHC1(7), SP1(7), STAT1(15), TGFB1(2), TGFB2(5), TGFB3(9), TGFBR1(5), TRAF2(3) 34631614 615 100 599 161 190 226 108 4 83 4 0.00610 1.000 1.000 317 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 106 A4GNT(7), ALG1(2), ALG10(6), ALG10B(6), ALG11(6), ALG12(7), ALG13(24), ALG14(2), ALG2(2), ALG3(1), ALG6(5), ALG8(10), ALG9(4), B3GNT1(5), B3GNT2(1), B3GNT7(3), B4GALT1(2), B4GALT2(5), B4GALT3(10), B4GALT4(5), B4GALT5(2), B4GALT7(4), C1GALT1(2), C1GALT1C1(6), CHPF(5), CHST1(8), CHST11(8), CHST12(3), CHST14(3), CHST2(2), CHST3(4), CHST4(4), CHST6(6), CHST7(4), CHSY1(8), DAD1(2), DDOST(3), DPAGT1(3), EXT1(12), EXT2(6), EXTL1(9), EXTL2(8), EXTL3(10), FUT11(4), FUT8(13), GALNT1(10), GALNT10(8), GALNT11(12), GALNT12(6), GALNT13(18), GALNT14(6), GALNT2(9), GALNT3(7), GALNT4(8), GALNT5(5), GALNT6(1), GALNT7(13), GALNT8(11), GALNT9(8), GALNTL1(8), GALNTL2(17), GALNTL4(6), GALNTL5(11), GANAB(10), GCNT1(5), GCNT3(5), GCNT4(1), HS2ST1(7), HS3ST1(5), HS3ST2(5), HS3ST3A1(2), HS3ST3B1(5), HS3ST5(9), HS6ST1(2), HS6ST2(12), HS6ST3(3), MAN1A1(13), MAN1A2(7), MAN1B1(5), MAN1C1(6), MAN2A1(20), MGAT1(4), MGAT2(4), MGAT3(4), MGAT4A(5), MGAT4B(6), MGAT5(11), MGAT5B(10), NDST1(14), NDST2(9), NDST3(14), NDST4(15), OGT(17), RPN1(3), RPN2(5), ST3GAL1(2), ST3GAL2(6), ST3GAL3(10), ST3GAL4(3), ST6GAL1(7), ST6GALNAC1(4), STT3B(5), UST(3), WBSCR17(15), XYLT1(16), XYLT2(4) 38860123 734 99 711 231 235 260 153 3 80 3 0.130 1.000 1.000 318 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 90 ACTB(3), BAD(2), CABIN1(19), CALM1(2), CALM2(4), CAMK2B(3), CAMK4(5), CD3E(2), CD3G(3), CD69(2), CDKN1A(1), CNR1(12), CREBBP(32), CSF2(1), CSNK2A1(9), CTLA4(2), EGR2(6), EGR3(7), EP300(32), FCER1A(9), FCGR3A(1), FKBP1B(1), FOS(3), FOSL1(3), GATA3(3), GATA4(3), GSK3A(10), GSK3B(13), HRAS(1), ICOS(3), IFNA1(2), IFNB1(3), IFNG(9), IL10(3), IL1B(2), IL2(2), IL2RA(4), IL3(2), IL4(1), IL6(5), IL8(3), ITK(7), KPNA5(7), MAP2K7(4), MAPK14(4), MAPK8(10), MAPK9(5), MEF2A(3), MEF2B(1), MEF2D(7), MYF5(6), NCK2(8), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(5), NFKB2(9), NFKBIB(1), NFKBIE(6), NPPB(3), NUP214(18), OPRD1(1), P2RX7(1), PAK1(3), PPIA(1), PPP3CB(5), PPP3CC(6), PPP3R1(1), PTPRC(17), RELA(6), RPL13A(1), SLA(6), SP1(7), SP3(10), TGFB1(2), TRAF2(3), TRPV6(10), VAV1(12), VAV2(7), VAV3(14), XPO5(11) 32447336 512 97 497 165 166 170 100 4 71 1 0.190 1.000 1.000 319 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 85 AICDA(5), AK3(2), CAD(25), CANT1(1), CDA(2), CTPS(11), CTPS2(8), DCK(5), DCTD(4), DHODH(3), DPYD(20), DPYS(6), DTYMK(2), ENTPD1(3), ENTPD3(5), ENTPD4(2), ENTPD5(2), ENTPD6(10), ENTPD8(5), ITPA(1), NME1(2), NME4(2), NME6(2), NME7(4), NT5C(1), NT5C1A(2), NT5C1B(8), NT5C2(6), NT5C3(8), NT5E(6), NT5M(3), NUDT2(2), PNPT1(7), POLA1(29), POLA2(3), POLD1(12), POLD2(6), POLD3(6), POLD4(1), POLE(47), POLE2(4), POLE3(3), POLE4(1), POLR1A(16), POLR1B(16), POLR1C(2), POLR1D(3), POLR2A(21), POLR2B(21), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(2), POLR2H(3), POLR2J(1), POLR2K(2), POLR3A(7), POLR3B(14), POLR3G(3), POLR3GL(2), POLR3H(5), PRIM1(3), RFC5(8), RRM1(2), RRM2(7), RRM2B(5), TK1(3), TK2(6), TXNRD1(10), TXNRD2(5), UCK1(7), UCK2(5), UMPS(7), UPB1(10), UPP1(4), UPP2(4), UPRT(8) 29373971 508 97 487 156 154 178 101 5 69 1 0.134 1.000 1.000 320 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 66 A2M(18), BDKRB1(3), BDKRB2(8), C1QA(5), C1QB(3), C1QC(4), C1R(11), C1S(8), C2(3), C3(22), C3AR1(9), C4BPA(6), C4BPB(6), C5(18), C5AR1(3), C6(16), C7(20), C8A(9), C8B(5), C8G(1), C9(19), CD46(3), CD55(7), CD59(4), CFB(3), CFH(22), CFI(8), CPB2(7), CR1(22), CR2(24), F10(14), F11(15), F12(2), F13A1(8), F13B(15), F2(8), F2R(6), F3(6), F5(48), F7(2), F8(45), F9(14), FGA(26), FGB(7), FGG(10), KLKB1(10), KNG1(12), MASP1(15), MASP2(7), MBL2(4), PLAT(6), PLAU(6), PLAUR(7), PLG(14), PROC(5), PROS1(21), SERPINA1(4), SERPINA5(5), SERPINC1(10), SERPIND1(7), SERPINE1(5), SERPINF2(4), SERPING1(7), TFPI(9), THBD(1), VWF(25) 32691403 707 96 679 205 183 307 120 4 88 5 0.0308 1.000 1.000 321 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 51 ACTG1(6), APAF1(17), ARHGDIB(3), BAG4(5), BID(2), BIRC2(10), BIRC3(5), CASP2(6), CASP3(4), CASP6(7), CASP7(4), CASP8(21), CASP9(3), CFLAR(6), CHUK(8), CRADD(3), CYCS(2), DAXX(10), DFFB(4), FADD(1), GSN(5), LMNA(7), LMNB1(5), LMNB2(4), MAP2K7(4), MAP3K1(30), MAP3K14(6), MAP3K5(25), MAPK8(10), MDM2(4), NFKB1(10), NFKBIA(3), NUMA1(21), PAK2(3), PRKCD(5), PRKDC(54), PSEN1(5), PSEN2(8), PTK2(12), RASA1(30), RB1(26), RELA(6), RIPK1(9), SPTAN1(31), TNFRSF1A(4), TNFRSF1B(2), TRAF1(5), TRAF2(3) 25165677 464 95 451 130 121 167 82 6 83 5 0.155 1.000 1.000 322 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(15), CD14(2), CD19(4), CD1A(5), CD1B(2), CD1C(14), CD1D(5), CD1E(6), CD2(4), CD22(14), CD33(6), CD34(1), CD36(8), CD37(1), CD38(6), CD3D(6), CD3E(2), CD3G(3), CD4(6), CD44(5), CD5(10), CD55(7), CD59(4), CD7(3), CD8A(2), CD8B(1), CD9(4), CR1(22), CR2(24), CSF1(6), CSF1R(8), CSF2(1), CSF2RA(12), CSF3(1), CSF3R(7), DNTT(3), EPO(2), EPOR(4), FCER2(1), FCGR1A(6), FLT3(16), FLT3LG(2), GP5(3), GP9(1), GYPA(2), HLA-DRA(1), HLA-DRB5(1), IL11(2), IL11RA(5), IL1B(2), IL1R1(5), IL1R2(5), IL2RA(4), IL3(2), IL3RA(9), IL4(1), IL4R(6), IL5(2), IL5RA(9), IL6(5), IL6R(7), IL7(1), IL7R(12), IL9R(7), ITGA1(17), ITGA2(19), ITGA2B(10), ITGA3(7), ITGA4(10), ITGA5(10), ITGA6(12), ITGAM(21), ITGB3(11), KIT(24), KITLG(3), MME(11), MS4A1(7), TFRC(4), THPO(7), TPO(15) 29769275 541 93 531 184 140 215 101 3 79 3 0.364 1.000 1.000 323 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 68 ACACB(29), ACSL1(14), ACSL3(7), ACSL4(21), ACSL5(9), ACSL6(12), ADIPOQ(2), ADIPOR1(3), ADIPOR2(7), AGRP(2), AKT1(4), AKT2(6), AKT3(11), CAMKK1(13), CAMKK2(7), CD36(8), CHUK(8), CPT1A(9), CPT1B(6), CPT1C(15), CPT2(4), G6PC(5), G6PC2(11), IKBKB(13), IKBKG(4), IRS1(13), IRS4(20), JAK1(20), JAK2(17), JAK3(10), LEP(2), LEPR(12), MAPK10(9), MAPK8(10), MAPK9(5), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NPY(2), PCK1(9), PCK2(7), POMC(4), PPARA(1), PPARGC1A(9), PRKAA1(8), PRKAA2(10), PRKAB1(6), PRKAB2(1), PRKAG1(3), PRKAG2(4), PRKAG3(6), PRKCQ(9), PTPN11(8), RELA(6), RXRA(3), RXRG(8), SLC2A1(2), SLC2A4(9), STAT3(10), STK11(2), TNFRSF1A(4), TNFRSF1B(2), TRAF2(3), TYK2(10) 28958077 523 90 511 189 152 200 96 5 64 6 0.600 1.000 1.000 324 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(12), CD28(3), CD3D(6), CSK(1), CTLA4(2), DAG1(6), DTYMK(2), EPHB2(12), FBXW7(46), GRB2(3), ITK(7), ITPKA(1), ITPKB(11), LCK(5), LCP2(5), MAPK1(2), NCK1(4), NFAT5(16), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NFKBIL1(2), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PAK7(9), PLCG1(12), PTPRC(17), RAF1(8), RASGRP1(8), RASGRP2(4), RASGRP3(11), RASGRP4(6), SOS1(13), SOS2(17), VAV1(12), ZAP70(8) 19923014 327 89 304 113 105 116 55 4 45 2 0.655 1.000 1.000 325 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(11), CREBBP(32), CTBP1(1), CTBP2(5), DLL1(7), DLL3(6), DLL4(6), DTX1(7), DTX2(4), DTX3(5), DTX3L(7), DTX4(4), DVL1(3), DVL2(10), DVL3(9), EP300(32), HDAC1(5), HDAC2(5), HES1(1), JAG1(23), JAG2(2), LFNG(2), MAML1(6), MAML2(9), MAML3(13), MFNG(3), NCOR2(23), NCSTN(9), NOTCH1(11), NOTCH2(18), NOTCH3(29), NOTCH4(9), NUMB(9), NUMBL(4), PSEN1(5), PSEN2(8), RBPJ(5), RBPJL(9), SNW1(6) 22970247 363 87 354 123 135 109 59 6 53 1 0.258 1.000 1.000 326 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 AK3(2), CAD(25), CANT1(1), CDA(2), CTPS(11), CTPS2(8), DCK(5), DCTD(4), DHODH(3), DPYD(20), DPYS(6), DTYMK(2), ENTPD1(3), ITPA(1), NME1(2), NT5C(1), NT5E(6), NT5M(3), NUDT2(2), POLB(4), POLD1(12), POLD2(6), POLE(47), POLG(6), POLL(7), POLQ(29), POLR1B(16), POLR2A(21), POLR2B(21), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(2), POLR2H(3), POLR2J(1), POLR2K(2), POLRMT(11), RRM1(2), RRM2(7), TK1(3), TK2(6), TXNRD1(10), UCK1(7), UCK2(5), UMPS(7), UNG(3), UPB1(10), UPP1(4) 20573408 368 84 350 108 112 144 66 1 44 1 0.0849 1.000 1.000 327 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(4), AKT2(6), AKT3(11), ASAH1(7), BRAF(10), DAG1(6), DRD2(8), EGFR(12), EPHB2(12), GRB2(3), ITPKA(1), ITPKB(11), ITPR1(34), ITPR2(35), ITPR3(21), KCNJ3(9), KCNJ5(7), KCNJ9(4), MAPK1(2), PI3(2), PIK3CB(17), PITX2(12), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), RAF1(8), RGS20(2), SHC1(7), SOS1(13), SOS2(17), SRC(3), STAT3(10), TERF2IP(2) 21223221 339 84 328 138 105 130 58 5 39 2 0.924 1.000 1.000 328 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 48 ADORA3(5), ALG6(5), CCKBR(3), CCR2(5), CCR3(4), CCR5(6), CELSR1(23), CELSR2(22), CELSR3(26), CHRM2(10), CHRM3(8), CIDEB(2), CXCR3(5), EDNRA(5), EMR2(6), EMR3(4), F2R(6), FSHR(16), GHRHR(2), GNRHR(4), GPR116(21), GPR132(6), GPR133(16), GPR135(4), GPR143(4), GPR17(6), GPR18(3), GPR55(3), GPR56(3), GPR61(4), GPR77(2), GPR84(3), GRM1(29), GRPR(4), HRH4(5), LGR6(13), LPHN2(22), LPHN3(21), LTB4R2(4), NTSR1(5), P2RY11(7), P2RY13(2), PTGFR(13), SMO(9), SSTR2(3), TAAR5(5), TSHR(8), VN1R1(5) 22229698 397 83 394 149 115 173 62 3 43 1 0.359 1.000 1.000 329 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 66 ADAM10(4), ADAM17(11), ATP6AP1(8), ATP6V0A1(7), ATP6V0A2(12), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(11), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1E2(4), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(7), CASP3(4), CCL5(2), CDC42(4), CHUK(8), CSK(1), CXCL1(3), EGFR(12), F11R(1), GIT1(9), HBEGF(2), IGSF5(5), IKBKB(13), IKBKG(4), IL8(3), JAM2(9), JAM3(3), JUN(1), LYN(9), MAP2K4(9), MAP3K14(6), MAPK10(9), MAPK11(3), MAPK12(3), MAPK13(4), MAPK14(4), MAPK8(10), MAPK9(5), MET(17), NFKB1(10), NFKB2(9), NFKBIA(3), NOD1(9), PAK1(3), PLCG1(12), PLCG2(27), PTPN11(8), PTPRZ1(46), RAC1(1), RELA(6), SRC(3), TCIRG1(6), TJP1(24) 25714605 471 83 465 148 122 194 84 2 66 3 0.287 1.000 1.000 330 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(4), APC(56), ASAH1(7), CAMP(1), DAG1(6), DLG4(11), EPHB2(12), GNAI1(5), GNAQ(3), ITPR1(34), ITPR2(35), ITPR3(21), KCNJ3(9), KCNJ5(7), KCNJ9(4), MAPK1(2), PITX2(12), PTX3(2), RAC1(1), RHO(4), RYR1(72) 16749934 308 83 297 129 84 145 37 3 35 4 0.875 1.000 1.000 331 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(17), CARM1(5), CCND1(14), CREBBP(32), EP300(32), ERCC3(11), ESR1(11), GRIP1(12), GTF2A1(3), GTF2E1(3), GTF2F1(7), HDAC1(5), HDAC2(5), HDAC3(12), HDAC4(14), HDAC5(12), HDAC6(25), MEF2C(11), NCOR2(23), NR0B1(8), NRIP1(17), PELP1(11), POLR2A(21), SRA1(1), TBP(3) 16878927 315 82 301 86 115 94 57 1 47 1 0.0172 1.000 1.000 332 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(6), AASDHPPT(9), AASS(12), ACAT1(6), ACAT2(4), AKR1B10(4), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2), BBOX1(1), DLST(9), DOT1L(8), ECHS1(3), EHHADH(11), EHMT1(23), EHMT2(2), GCDH(6), HADH(1), HADHA(6), HSD17B10(4), HSD17B4(13), HSD3B7(5), NSD1(37), OGDH(13), OGDHL(19), PIPOX(4), PLOD1(4), PLOD2(13), PLOD3(7), RDH11(1), RDH12(5), RDH13(4), RDH14(2), SETD1A(12), SETD7(7), SETDB1(16), SHMT1(5), SHMT2(5), SPCS3(2), SUV39H1(9), SUV39H2(5), TMLHE(6) 20158536 340 82 329 110 117 114 69 9 30 1 0.226 1.000 1.000 333 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(6), BMP4(10), BMP5(14), BMP6(5), BMP7(12), BMP8A(3), BMP8B(1), BTRC(14), CSNK1A1(4), CSNK1A1L(4), CSNK1D(3), CSNK1E(3), CSNK1G1(6), CSNK1G2(2), CSNK1G3(8), DHH(2), FBXW11(5), GLI1(13), GLI2(10), GLI3(28), GSK3B(13), HHIP(13), IHH(3), LRP2(91), PRKACA(6), PRKACB(3), PRKACG(9), PRKX(2), PTCH1(22), PTCH2(10), RAB23(4), SHH(4), SMO(9), STK36(6), SUFU(3), WNT1(1), WNT10A(2), WNT10B(2), WNT11(6), WNT16(7), WNT2(3), WNT2B(6), WNT3(3), WNT3A(1), WNT4(1), WNT5A(7), WNT5B(3), WNT6(1), WNT7A(3), WNT7B(2), WNT8A(2), WNT8B(5), WNT9A(4), WNT9B(2), ZIC2(1) 20670823 413 81 404 143 151 160 57 4 39 2 0.289 1.000 1.000 334 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 65 AGTR1(4), AGTR2(11), ATP8A1(15), AVPR1A(7), AVPR1B(3), AVPR2(5), BDKRB1(3), BDKRB2(8), BRS3(17), C3AR1(9), CCKAR(9), CCKBR(3), CCR1(4), CCR2(5), CCR3(4), CCR4(5), CCR5(6), CCR6(5), CCR7(6), CCR8(6), CX3CR1(6), CXCR3(5), CXCR4(1), CXCR6(1), EDNRA(5), EDNRB(4), FPR1(2), FSHR(16), GALR1(3), GALR3(2), GALT(3), GHSR(8), GNB2L1(1), GNRHR(4), GPR77(2), GRPR(4), LHCGR(17), MC1R(3), MC2R(4), MC3R(5), MC4R(5), MC5R(14), NMBR(4), NPY1R(9), NPY2R(5), NPY5R(13), NTSR1(5), NTSR2(1), OPRD1(1), OPRK1(10), OPRL1(3), OPRM1(13), OXTR(4), PPYR1(8), SSTR1(10), SSTR2(3), SSTR3(3), SSTR4(10), TACR1(7), TACR2(3), TACR3(9), TRHR(3), TSHR(8) 18351949 382 81 370 142 115 167 51 6 43 0 0.146 1.000 1.000 335 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(17), AMY2A(4), AMY2B(11), ENPP1(12), ENPP3(18), G6PC(5), GAA(4), GANAB(10), GBA3(9), GBE1(9), GCK(3), GPI(7), GUSB(5), GYS1(13), GYS2(16), HK1(11), HK2(9), HK3(10), MGAM(51), PGM1(7), PGM3(4), PYGB(11), PYGL(8), PYGM(10), RNPC3(6), SI(65), UCHL1(4), UCHL3(1), UGDH(2), UGT1A1(6), UGT1A10(7), UGT1A3(2), UGT1A4(5), UGT1A5(7), UGT1A6(3), UGT1A7(7), UGT1A8(5), UGT1A9(3), UGT2B15(9), UGT2B4(11), UXS1(5) 21023868 412 81 407 107 101 154 96 5 56 0 0.0279 1.000 1.000 336 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(22), ATP4A(9), ATP4B(4), ATP5A1(8), ATP5B(5), ATP5C1(1), ATP5D(1), ATP5E(2), ATP5F1(4), ATP5G1(3), ATP5G2(1), ATP5G3(1), ATP5H(1), ATP5I(2), ATP5J(3), ATP5L(1), ATP5O(1), ATP6AP1(8), ATP6V0A1(7), ATP6V0A2(12), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(11), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1E2(4), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(7), COX10(3), COX15(3), COX17(1), COX4I1(3), COX5A(1), COX5B(1), COX6A1(3), COX6A2(1), COX6B1(1), COX6C(3), COX7A1(3), COX7B(4), COX7B2(3), COX7C(2), COX8A(1), COX8C(1), CYC1(3), LHPP(2), NDUFA1(1), NDUFA10(7), NDUFA13(1), NDUFA2(3), NDUFA3(4), NDUFA4(1), NDUFA4L2(1), NDUFA5(4), NDUFA6(2), NDUFA8(5), NDUFA9(5), NDUFAB1(2), NDUFB1(1), NDUFB10(1), NDUFB11(3), NDUFB7(3), NDUFB8(1), NDUFC1(1), NDUFC2(1), NDUFS1(13), NDUFS2(7), NDUFS4(3), NDUFS5(1), NDUFS7(2), NDUFS8(3), NDUFV1(3), NDUFV2(2), PPA1(4), PPA2(5), SDHA(15), SDHB(2), SDHC(4), SDHD(3), TCIRG1(6), UQCRB(4), UQCRC1(2), UQCRC2(7), UQCRFS1(3), UQCRH(1), UQCRQ(2) 20433737 373 80 369 103 121 140 54 2 55 1 0.0236 1.000 1.000 337 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(6), AANAT(2), ABP1(5), ACAT1(6), ACAT2(4), ACMSD(8), AFMID(6), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2), AOC2(7), AOC3(10), AOX1(18), ASMT(5), CARM1(5), CAT(4), CYP1A1(12), CYP1A2(11), CYP1B1(2), DDC(9), ECHS1(3), EHHADH(11), GCDH(6), HAAO(2), HADH(1), HADHA(6), HEMK1(3), HSD17B10(4), HSD17B4(13), INMT(2), KMO(11), KYNU(7), LCMT1(2), LCMT2(9), LNX1(9), MAOA(12), MAOB(7), METTL2B(4), METTL6(5), NFX1(15), OGDH(13), OGDHL(19), PRMT2(4), PRMT3(9), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), TDO2(3), TPH1(9), TPH2(4), WARS(6), WARS2(3), WBSCR22(5) 21980296 385 80 373 113 112 148 77 6 40 2 0.0538 1.000 1.000 338 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 66 ACAA1(5), ACADL(8), ACADM(9), ACOX1(7), ACOX2(8), ACOX3(8), ACSL1(14), ACSL3(7), ACSL4(21), ACSL5(9), ACSL6(12), ADIPOQ(2), APOA1(3), APOA2(2), APOA5(2), APOC3(1), AQP7(4), CD36(8), CPT1A(9), CPT1B(6), CPT1C(15), CPT2(4), CYP27A1(9), CYP4A11(7), CYP4A22(7), CYP7A1(11), CYP8B1(4), DBI(1), EHHADH(11), FABP1(4), FABP2(2), FABP3(1), FABP4(2), FABP5(3), FABP6(3), FABP7(2), FADS2(2), GK(17), GK2(20), HMGCS2(9), ILK(5), LPL(16), ME1(12), MMP1(3), NR1H3(4), OLR1(2), PCK1(9), PCK2(7), PDPK1(3), PLTP(7), PPARA(1), PPARD(3), PPARG(6), RXRA(3), RXRG(8), SCD(6), SCP2(9), SLC27A1(10), SLC27A2(3), SLC27A4(5), SLC27A5(3), SLC27A6(9), SORBS1(18), UBC(8), UCP1(2) 23302521 441 80 432 131 134 167 89 1 50 0 0.0772 1.000 1.000 339 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), AGK(10), AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPAT6(6), AKR1A1(1), AKR1B1(1), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2), CEL(5), DAK(4), DGAT1(3), DGAT2(6), DGKA(10), DGKB(22), DGKD(18), DGKE(5), DGKG(11), DGKH(11), DGKI(20), DGKQ(2), DGKZ(10), GK(17), GK2(20), GLA(9), GLB1(6), GPAM(9), LCT(32), LIPA(8), LIPC(8), LIPF(7), LIPG(7), LPL(16), MGLL(2), PNLIP(6), PNLIPRP1(6), PNLIPRP2(9), PNPLA3(7), PPAP2A(6), PPAP2B(3), PPAP2C(1) 21221405 406 77 397 132 126 152 86 3 38 1 0.158 1.000 1.000 340 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 36 EEF1A2(4), EEF1B2(3), EEF1D(8), EEF1G(5), EEF2(13), EEF2K(11), EIF1AX(4), EIF2AK1(8), EIF2AK2(13), EIF2AK3(12), EIF2B2(5), EIF2B3(7), EIF2B4(4), EIF2B5(5), EIF2S1(2), EIF2S2(9), EIF2S3(6), EIF4A1(5), EIF4A2(9), EIF4E(2), EIF4EBP2(1), EIF4G1(15), EIF4G3(24), EIF5(3), EIF5A(5), EIF5B(15), ETF1(7), GSPT2(18), KIAA0664(13), PABPC1(10), PABPC3(8), PAIP1(6), SLC35A4(5) 15890643 265 76 258 65 87 92 42 6 34 4 0.0179 1.000 1.000 341 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 54 ABP1(5), ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), ALDH1A3(8), ALDH3A1(7), ALDH3B2(7), AOC2(7), AOC3(10), AOX1(18), CARM1(5), COMT(3), DBH(9), DCT(13), DDC(9), ECH1(2), ESCO1(16), ESCO2(8), FAH(6), GOT1(9), GOT2(3), GSTZ1(5), HEMK1(3), HGD(4), HPD(2), LCMT1(2), LCMT2(9), MAOA(12), MAOB(7), METTL2B(4), METTL6(5), NAT6(1), PNMT(2), PNPLA3(7), PRMT2(4), PRMT3(9), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), SH3GLB1(7), TAT(7), TH(3), TPO(15), TYR(12), TYRP1(7), WBSCR22(5) 21082149 344 75 337 96 100 129 66 4 45 0 0.0291 1.000 1.000 342 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(8), AGTR2(11), CALM1(2), CALM2(4), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CDK5(2), F2(8), FYN(7), GNA11(2), GNAI1(5), GNB1(2), GNGT1(1), GRB2(3), HRAS(1), JAK2(17), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(10), MAPT(9), MYLK(14), PLCG1(12), PRKCA(10), PTK2B(16), RAF1(8), SHC1(7), SOS1(13), STAT1(15), STAT3(10), STAT5A(5), SYT1(4) 15149973 244 74 235 89 87 84 44 1 25 3 0.609 1.000 1.000 343 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 37 ATF2(8), CDC42(4), CREB1(6), DAXX(10), DDIT3(2), ELK1(3), GRB2(3), HMGN1(2), HRAS(1), HSPB2(1), MAP2K4(9), MAP2K6(10), MAP3K1(30), MAP3K5(25), MAP3K7(9), MAP3K9(6), MAPK14(4), MAPKAPK2(6), MAPKAPK5(5), MAX(12), MEF2A(3), MEF2B(1), MEF2C(11), MEF2D(7), MKNK1(3), MYC(8), PLA2G4A(13), RAC1(1), RIPK1(9), RPS6KA5(11), SHC1(7), STAT1(15), TGFB1(2), TGFB2(5), TGFB3(9), TGFBR1(5), TRAF2(3) 13320121 269 74 260 64 75 106 52 1 34 1 0.0235 1.000 1.000 344 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 34 ACTG1(6), ACTR2(6), ACTR3(1), AKT1(4), ANGPTL2(6), CDC42(4), CFL1(1), CFL2(8), FLNA(40), FLNC(37), FSCN1(5), FSCN3(5), GDI1(4), GDI2(1), LIMK1(8), MYH2(43), MYLK(14), MYLK2(8), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PAK7(9), PFN1(1), PFN2(2), RHO(4), ROCK1(22), ROCK2(17), RPS4X(1), VASP(3), WASF1(3), WASL(8) 16540338 298 74 295 89 91 126 43 3 33 2 0.0350 1.000 1.000 345 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(3), CDC7(11), CDK2(2), CDT1(3), DIAPH2(31), GMNN(2), MCM10(8), MCM2(7), MCM3(9), MCM4(11), MCM5(8), MCM6(6), MCM7(6), NACA(20), PCNA(3), POLA2(3), POLD1(12), POLD2(6), POLD3(6), POLD4(1), POLE(47), POLE2(4), PRIM1(3), RFC1(21), RFC2(4), RFC3(4), RFC4(5), RFC5(8), RPA1(6), RPA2(3), RPA3(3), RPA4(4), RPS27A(4), UBA52(1), UBB(2), UBC(8) 18401804 285 73 264 74 74 135 39 3 32 2 0.0778 1.000 1.000 346 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(12), ADCY6(14), ADCY8(22), CACNA1A(19), CACNA1B(35), GNAS(24), GNAT3(8), GNB1(2), GNB3(2), GNG13(2), GNG3(2), GRM4(12), ITPR3(21), KCNB1(13), PDE1A(15), PLCB2(8), PRKACA(6), PRKACB(3), PRKACG(9), PRKX(2), SCNN1A(3), SCNN1B(4), SCNN1G(9), TAS1R1(10), TAS1R2(11), TAS1R3(4), TAS2R1(4), TAS2R10(9), TAS2R13(3), TAS2R14(6), TAS2R16(4), TAS2R3(4), TAS2R38(5), TAS2R39(9), TAS2R4(3), TAS2R40(5), TAS2R41(4), TAS2R42(4), TAS2R43(1), TAS2R46(2), TAS2R5(4), TAS2R50(4), TAS2R60(6), TAS2R7(3), TAS2R8(6), TAS2R9(3), TRPM5(9) 20433711 370 73 363 145 125 139 71 2 33 0 0.690 1.000 1.000 347 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(22), ATP4B(4), ATP5E(2), ATP5O(1), ATP6AP1(8), ATP6V0A1(7), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(7), ATP7A(29), ATP7B(13), COX10(3), COX4I1(3), COX5A(1), COX5B(1), COX6A1(3), COX6A2(1), COX6B1(1), COX6C(3), COX7A1(3), COX7B(4), COX7C(2), COX8A(1), NDUFA1(1), NDUFA10(7), NDUFA4(1), NDUFA5(4), NDUFA8(5), NDUFB7(3), NDUFS1(13), NDUFS2(7), NDUFV1(3), NDUFV2(2), PPA2(5), SDHA(15), SDHB(2), SHMT1(5), UQCRB(4), UQCRC1(2), UQCRFS1(3), UQCRH(1) 14142139 279 73 275 73 80 112 40 2 44 1 0.0205 1.000 1.000 348 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 35 AKT1(4), AKT2(6), AKT3(11), ARHGEF11(20), CDC42(4), DLG4(11), GNA13(7), IKBKG(4), LPA(15), MAP2K4(9), MAP3K1(30), MAP3K5(25), MAPK8(10), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NFKBIL1(2), PDK1(2), PHKA2(21), PI3(2), PIK3CB(17), PLD1(14), PLD2(10), PLD3(5), PTK2(12), RDX(16), ROCK1(22), ROCK2(17), SERPINA4(4), SRF(3) 17689412 332 73 320 84 104 108 56 0 61 3 0.0342 1.000 1.000 349 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), AGPAT2(2), AGPAT3(4), AGPAT4(5), AKR1A1(1), AKR1B1(1), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH9A1(2), CEL(5), DGAT1(3), DGKA(10), DGKB(22), DGKD(18), DGKE(5), DGKG(11), DGKH(11), DGKQ(2), DGKZ(10), GK(17), GLA(9), GLB1(6), LCT(32), LIPC(8), LIPF(7), LIPG(7), LPL(16), PNLIP(6), PNLIPRP1(6), PNLIPRP2(9), PPAP2A(6), PPAP2B(3), PPAP2C(1) 17350704 333 72 329 102 101 121 76 3 32 0 0.0751 1.000 1.000 350 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 23 POLA1(29), POLA2(3), POLB(4), POLD1(12), POLD2(6), POLD3(6), POLD4(1), POLE(47), POLE2(4), POLE3(3), POLE4(1), POLG(6), POLG2(3), POLH(12), POLI(6), POLK(11), POLL(7), POLM(8), POLQ(29), PRIM1(3), REV1(13), REV3L(35), RFC5(8) 14833216 257 72 238 60 60 107 48 3 38 1 0.0642 1.000 1.000 351 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 CHUK(8), DAXX(10), EGF(19), EGFR(12), ETS1(6), ETS2(6), FOS(3), HOXA7(8), HRAS(1), IKBKB(13), JUN(1), MAP2K1(2), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP2K7(4), MAP3K1(30), MAP3K14(6), MAP3K5(25), MAPK1(2), MAPK13(4), MAPK14(4), MAPK3(3), MAPK8(10), NFKB1(10), NFKBIA(3), PPP2CA(6), PRKCA(10), PRKCD(5), PRKCE(10), PRKCG(8), PRKCH(10), PRKCQ(9), RAF1(8), RELA(6), RIPK1(9), SP1(7), TNFRSF1A(4), TNFRSF1B(2), TRAF2(3) 17531738 313 72 305 94 89 113 58 2 49 2 0.145 1.000 1.000 352 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 27 ADRBK1(8), AKT1(4), AKT2(6), AKT3(11), DAG1(6), GNAQ(3), IKBKG(4), ITPKA(1), ITPKB(11), ITPR1(34), ITPR2(35), ITPR3(21), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NFKBIL1(2), PDK1(2), PHKA2(21), PIK3CB(17), PITX2(12), PLD1(14), PLD2(10), PLD3(5), VN1R1(5) 16052704 261 72 253 90 83 100 34 1 42 1 0.363 1.000 1.000 353 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 63 ACSS1(5), ACSS2(6), ACYP1(2), ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), AKR1A1(1), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH3B2(7), ALDH7A1(2), ALDH9A1(2), ALDOA(5), ALDOB(9), ALDOC(3), BPGM(1), DLAT(3), DLD(5), ENO1(6), ENO2(4), ENO3(5), FBP1(2), FBP2(1), G6PC(5), G6PC2(11), GALM(1), GAPDH(3), GAPDHS(10), GCK(3), GPI(7), HK1(11), HK2(9), HK3(10), LDHA(8), LDHAL6A(8), LDHAL6B(2), LDHB(3), LDHC(4), PDHA1(7), PDHA2(9), PDHB(3), PFKL(8), PFKM(9), PFKP(8), PGAM1(3), PGAM2(1), PGAM4(5), PGK1(7), PGK2(6), PGM1(7), PGM3(4), PKLR(7), PKM2(5), TPI1(2) 20778184 322 71 319 112 102 124 59 2 35 0 0.396 1.000 1.000 354 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(5), AKT1(4), BDKRB2(8), CALM1(2), CALM2(4), CAV1(2), CHRM1(6), CHRNA1(7), FLT1(20), FLT4(9), KDR(26), NOS3(11), PDE2A(14), PDE3A(19), PDE3B(15), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKG1(11), PRKG2(11), RYR2(111), SLC7A1(8), SYT1(4), TNNI1(1) 14841596 325 71 317 113 94 123 62 3 39 4 0.431 1.000 1.000 355 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 39 ALK(18), AR(12), ESR1(11), ESR2(5), ESRRA(2), HNF4A(13), NPM1(3), NR0B1(8), NR1D1(3), NR1D2(2), NR1H2(3), NR1H3(4), NR1I2(3), NR1I3(6), NR2C2(7), NR2E1(8), NR2F1(7), NR2F2(5), NR2F6(4), NR3C1(18), NR4A1(5), NR4A2(11), NR5A1(3), NR5A2(13), PGR(13), PPARA(1), PPARD(3), PPARG(6), RARA(2), RARB(4), RARG(6), ROR1(10), RORA(11), RORC(8), RXRA(3), RXRG(8), THRA(6), THRB(4), VDR(8) 14380270 267 71 257 85 97 97 47 3 22 1 0.167 1.000 1.000 356 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(8), AARS2(7), CARS(9), CARS2(5), DARS(7), DARS2(10), EARS2(5), EPRS(15), FARS2(2), FARSA(6), FARSB(7), GARS(8), HARS(5), HARS2(7), IARS(8), IARS2(20), KARS(5), LARS(18), LARS2(8), MARS(11), MARS2(4), NARS(11), NARS2(10), PARS2(4), QARS(7), RARS(13), RARS2(8), SARS(4), SARS2(6), TARS(9), TARS2(10), VARS(6), VARS2(1), WARS(6), WARS2(3), YARS(5), YARS2(3) 19060344 281 70 276 90 89 112 51 3 26 0 0.622 1.000 1.000 357 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 58 A4GALT(2), B3GALNT1(6), B3GALT1(12), B3GALT2(8), B3GALT4(3), B3GALT5(4), B3GNT1(5), B3GNT2(1), B3GNT3(5), B3GNT4(4), B3GNT5(6), B4GALNT1(6), B4GALT1(2), B4GALT2(5), B4GALT3(10), B4GALT4(5), B4GALT6(6), FUT1(4), FUT2(1), FUT3(8), FUT5(1), FUT6(10), FUT7(2), FUT9(9), GBGT1(7), GCNT2(11), PIGA(8), PIGB(11), PIGC(3), PIGF(2), PIGG(6), PIGH(5), PIGK(9), PIGL(1), PIGM(1), PIGN(13), PIGO(9), PIGP(3), PIGQ(5), PIGS(1), PIGT(7), PIGU(3), PIGV(7), PIGX(2), PIGZ(5), ST3GAL1(2), ST3GAL2(6), ST3GAL3(10), ST3GAL4(3), ST3GAL5(5), ST3GAL6(6), ST6GALNAC3(8), ST6GALNAC4(4), ST6GALNAC5(2), ST6GALNAC6(6), ST8SIA1(2), ST8SIA5(8), UGCG(4) 16968686 310 70 303 75 105 117 52 2 34 0 0.000929 1.000 1.000 358 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), AKR1C1(6), AKR1C2(3), AKR1C3(2), AKR1C4(6), ALDH1A3(8), ALDH3A1(7), ALDH3B2(7), CYP1A1(12), CYP1A2(11), CYP1B1(2), CYP2B6(14), CYP2C18(5), CYP2C19(6), CYP2C8(7), CYP2C9(5), CYP2E1(2), CYP2F1(4), CYP2S1(8), CYP3A4(10), CYP3A43(4), CYP3A5(6), CYP3A7(7), DHDH(4), EPHX1(2), GSTA1(2), GSTA2(6), GSTA3(5), GSTA4(3), GSTA5(4), GSTK1(6), GSTM1(2), GSTM2(3), GSTM3(5), GSTM4(1), GSTM5(2), GSTO2(1), GSTP1(2), GSTT1(1), GSTT2(1), GSTZ1(5), MGST1(4), MGST3(2), UGT1A1(6), UGT1A10(7), UGT1A3(2), UGT1A4(5), UGT1A5(7), UGT1A6(3), UGT1A7(7), UGT1A8(5), UGT1A9(3), UGT2A1(11), UGT2A3(5), UGT2B10(18), UGT2B11(18), UGT2B15(9), UGT2B17(7), UGT2B28(21), UGT2B4(11), UGT2B7(5) 20623799 393 69 380 95 104 167 74 4 44 0 0.00180 1.000 1.000 359 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 31 ADRA1A(12), ADRA1B(6), ADRA1D(1), ADRA2A(6), ADRA2C(2), ADRB2(7), ADRB3(3), CHRM1(6), CHRM2(10), CHRM3(8), CHRM4(9), CHRM5(9), DRD1(6), DRD2(8), DRD3(6), DRD5(11), HRH1(10), HRH2(4), HTR1A(14), HTR1B(6), HTR1D(6), HTR1E(11), HTR1F(11), HTR2A(11), HTR2B(2), HTR2C(17), HTR4(8), HTR5A(12), HTR6(4), HTR7(5) 8984624 231 69 223 81 91 84 42 3 11 0 0.0556 1.000 1.000 360 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(6), ACTR3(1), ARHGAP1(2), ARHGAP4(11), ARHGAP5(21), ARHGAP6(18), ARHGEF1(12), ARHGEF11(20), ARHGEF5(13), ARPC1A(6), ARPC1B(5), ARPC2(1), ARPC3(1), ARPC4(1), BAIAP2(5), CFL1(1), DIAPH1(12), GSN(5), LIMK1(8), MYL2(2), MYLK(14), OPHN1(15), PFN1(1), PIP5K1A(8), PIP5K1B(5), PPP1R12B(20), ROCK1(22), SRC(3), TLN1(23), VCL(11) 16688465 273 69 268 93 100 100 48 0 23 2 0.578 1.000 1.000 361 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 27 ARHGDIB(3), BAG4(5), CASP2(6), CASP3(4), CASP8(21), CRADD(3), DFFB(4), FADD(1), JUN(1), LMNA(7), LMNB1(5), LMNB2(4), MADD(17), MAP2K4(9), MAP3K1(30), MAP3K7(9), MAPK8(10), PAK1(3), PAK2(3), PRKDC(54), RB1(26), RIPK1(9), SPTAN1(31), TNFRSF1A(4), TRAF2(3) 14248497 272 69 264 84 76 80 52 4 56 4 0.530 1.000 1.000 362 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(2), ABP1(5), ACAT1(6), ACAT2(4), ACMSD(8), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH9A1(2), AOC2(7), AOC3(10), AOX1(18), ASMT(5), CAT(4), CYP19A1(13), CYP1A1(12), CYP1A2(11), CYP2A13(8), CYP2A6(11), CYP2A7(5), CYP2B6(14), CYP2C18(5), CYP2C19(6), CYP2C8(7), CYP2C9(5), CYP2D6(2), CYP2E1(2), CYP2F1(4), CYP2J2(5), CYP3A4(10), CYP3A5(6), CYP3A7(7), CYP4B1(4), CYP4F8(7), CYP51A1(4), DDC(9), ECHS1(3), EHHADH(11), GCDH(6), HAAO(2), HADHA(6), KMO(11), KYNU(7), MAOA(12), MAOB(7), SDS(1), TDO2(3), TPH1(9), WARS(6), WARS2(3) 20087936 363 69 357 124 99 145 73 4 39 3 0.472 1.000 1.000 363 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(4), BTK(12), CALM1(2), CALM2(4), CD79A(1), CD79B(2), ELK1(3), FOS(3), GRB2(3), HRAS(1), JUN(1), LYN(9), MAP2K1(2), MAP3K1(30), MAPK14(4), MAPK3(3), MAPK8(10), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(5), PLCG1(12), PPP3CA(4), PPP3CB(5), PPP3CC(6), PRKCA(10), RAC1(1), RAF1(8), SHC1(7), SOS1(13), SYK(4), SYT1(4), VAV1(12) 13601950 220 68 212 72 67 80 47 1 24 1 0.458 1.000 1.000 364 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(9), ACAA1(5), ACAA2(3), ACADM(9), ACADS(3), ACAT1(6), ACAT2(4), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH6A1(6), ALDH7A1(2), ALDH9A1(2), AOX1(18), AUH(4), BCAT1(7), BCAT2(3), BCKDHA(6), BCKDHB(3), DBT(5), DLD(5), ECHS1(3), EHHADH(11), HADH(1), HADHA(6), HADHB(4), HIBADH(5), HIBCH(6), HMGCL(2), HMGCS1(6), HMGCS2(9), HSD17B10(4), HSD17B4(13), IVD(2), MCCC1(9), MCCC2(5), MCEE(1), MUT(10), OXCT1(10), OXCT2(2), PCCA(6), PCCB(9) 15810646 251 68 247 70 62 101 58 2 28 0 0.117 1.000 1.000 365 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(4), AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPAT6(6), CDS1(5), CHAT(5), CHKA(9), CHKB(6), CHPT1(1), DGKA(10), DGKB(22), DGKD(18), DGKE(5), DGKG(11), DGKH(11), DGKI(20), DGKQ(2), DGKZ(10), ESCO1(16), ESCO2(8), ETNK1(10), ETNK2(3), GNPAT(11), GPAM(9), GPD1(3), GPD1L(4), GPD2(3), LCAT(4), LYPLA1(1), LYPLA2(7), NAT6(1), PCYT1A(4), PCYT1B(4), PEMT(1), PISD(2), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLD1(14), PLD2(10), PNPLA3(7), PPAP2A(6), PPAP2B(3), PPAP2C(1), PTDSS1(5), PTDSS2(2), SH3GLB1(7) 23545860 347 68 342 126 108 124 69 3 42 1 0.740 1.000 1.000 366 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(5), ACTN1(9), ACTN2(16), ACTN3(10), BCAR1(8), BCR(6), CAPN1(5), CAPNS1(2), CAPNS2(3), CAV1(2), CRKL(6), CSK(1), FYN(7), GRB2(3), HRAS(1), ITGA1(17), ITGB1(8), JUN(1), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), MAPK8(10), PPP1R12B(20), PTK2(12), PXN(6), RAF1(8), RAP1A(4), ROCK1(22), SHC1(7), SOS1(13), SRC(3), TLN1(23), VCL(11), ZYX(11) 16913420 272 68 264 77 102 87 50 0 32 1 0.0384 1.000 1.000 367 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(8), AGTR1(4), ATF2(8), CALM1(2), CALM2(4), EGFR(12), ELK1(3), GNAQ(3), GRB2(3), HRAS(1), JUN(1), MAP2K1(2), MAP2K2(5), MAP2K4(9), MAP3K1(30), MAPK1(2), MAPK3(3), MAPK8(10), MEF2A(3), MEF2B(1), MEF2C(11), MEF2D(7), PAK1(3), PRKCA(10), PTK2(12), PTK2B(16), RAC1(1), RAF1(8), SHC1(7), SOS1(13), SRC(3), SYT1(4) 12424151 209 67 202 65 60 76 41 0 31 1 0.309 1.000 1.000 368 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(3), CASP10(8), CASP3(4), CASP6(7), CASP7(4), CASP8(21), CFLAR(6), DAXX(10), DFFB(4), FADD(1), FAF1(10), JUN(1), LMNA(7), LMNB1(5), LMNB2(4), MAP2K4(9), MAP3K1(30), MAP3K7(9), MAPK8(10), PAK1(3), PAK2(3), PRKDC(54), PTPN13(30), RB1(26), RIPK2(6), SPTAN1(31) 15656179 306 67 297 82 75 103 58 4 62 4 0.256 1.000 1.000 369 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(1), AKR1B10(4), B4GALT1(2), B4GALT2(5), G6PC(5), G6PC2(11), GAA(4), GALE(1), GALK1(1), GALK2(3), GALT(3), GANC(15), GCK(3), GLA(9), GLB1(6), HK1(11), HK2(9), HK3(10), HSD3B7(5), LALBA(2), LCT(32), MGAM(51), PFKL(8), PFKM(9), PFKP(8), PGM1(7), PGM3(4), RDH11(1), RDH12(5), RDH13(4), RDH14(2), UGP2(6) 13671150 247 67 243 91 83 89 47 3 25 0 0.615 1.000 1.000 370 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 53 AKR1C4(6), AKR1D1(8), ARSD(6), ARSE(10), CARM1(5), CYP11B1(8), CYP11B2(8), CYP19A1(13), HEMK1(3), HSD11B1(6), HSD17B1(4), HSD17B12(4), HSD17B2(2), HSD17B3(6), HSD17B7(5), HSD17B8(2), HSD3B1(3), HSD3B2(6), LCMT1(2), LCMT2(9), METTL2B(4), METTL6(5), PRMT2(4), PRMT3(9), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), SRD5A1(6), STS(8), SULT1E1(9), SULT2A1(7), SULT2B1(4), UGT1A1(6), UGT1A10(7), UGT1A3(2), UGT1A4(5), UGT1A5(7), UGT1A6(3), UGT1A7(7), UGT1A8(5), UGT1A9(3), UGT2A1(11), UGT2A3(5), UGT2B10(18), UGT2B11(18), UGT2B15(9), UGT2B17(7), UGT2B28(21), UGT2B4(11), UGT2B7(5), WBSCR22(5) 17574364 354 67 340 97 79 166 58 3 46 2 0.0271 1.000 1.000 371 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 41 ACACA(33), ACACB(29), ACAT1(6), ACAT2(4), ACOT12(11), ACSS1(5), ACSS2(6), ACYP1(2), AKR1B1(1), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2), DLAT(3), DLD(5), GRHPR(3), LDHA(8), LDHAL6A(8), LDHAL6B(2), LDHB(3), LDHC(4), LDHD(2), MDH1(4), MDH2(4), ME1(12), ME2(8), ME3(9), PC(12), PCK1(9), PCK2(7), PDHA1(7), PDHA2(9), PDHB(3), PKLR(7), PKM2(5) 16736435 262 67 254 92 84 97 43 5 32 1 0.563 1.000 1.000 372 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(8), CALM1(2), CALM2(4), CRKL(6), GNAQ(3), GRB2(3), HRAS(1), JUN(1), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K4(9), MAP3K1(30), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(10), PAK1(3), PLCG1(12), PRKCA(10), PTK2B(16), RAC1(1), RAF1(8), SHC1(7), SOS1(13), SRC(3), SYT1(4) 10198568 177 67 170 58 53 64 35 0 24 1 0.500 1.000 1.000 373 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(56), CDH1(14), CREBBP(32), EP300(32), MAP2K1(2), MAP3K7(9), MAPK3(3), SKIL(7), TGFB1(2), TGFB2(5), TGFB3(9), TGFBR1(5), TGFBR2(6) 9444442 182 67 173 49 48 62 36 2 30 4 0.218 1.000 1.000 374 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 52 ACYP1(2), ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), AKR1A1(1), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH3B2(7), ALDH9A1(2), ALDOA(5), ALDOB(9), ALDOC(3), BPGM(1), DLAT(3), DLD(5), ENO1(6), ENO2(4), ENO3(5), FBP1(2), FBP2(1), G6PC(5), GAPDH(3), GCK(3), GPI(7), HK1(11), HK2(9), HK3(10), LDHA(8), LDHB(3), LDHC(4), PDHA1(7), PDHA2(9), PDHB(3), PFKM(9), PFKP(8), PGAM1(3), PGK1(7), PGM1(7), PGM3(4), PKLR(7), PKM2(5), TPI1(2) 17484356 278 66 276 92 86 103 51 2 36 0 0.265 1.000 1.000 375 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 52 ACYP1(2), ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), AKR1A1(1), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH3B2(7), ALDH9A1(2), ALDOA(5), ALDOB(9), ALDOC(3), BPGM(1), DLAT(3), DLD(5), ENO1(6), ENO2(4), ENO3(5), FBP1(2), FBP2(1), G6PC(5), GAPDH(3), GCK(3), GPI(7), HK1(11), HK2(9), HK3(10), LDHA(8), LDHB(3), LDHC(4), PDHA1(7), PDHA2(9), PDHB(3), PFKM(9), PFKP(8), PGAM1(3), PGK1(7), PGM1(7), PGM3(4), PKLR(7), PKM2(5), TPI1(2) 17484356 278 66 276 92 86 103 51 2 36 0 0.265 1.000 1.000 376 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 50 AKR1C3(2), ALOX12(8), ALOX12B(10), ALOX15(9), ALOX15B(6), ALOX5(10), CBR1(4), CBR3(2), CYP2B6(14), CYP2C18(5), CYP2C19(6), CYP2C8(7), CYP2C9(5), CYP2E1(2), CYP2J2(5), CYP2U1(2), CYP4A11(7), CYP4A22(7), CYP4F2(12), CYP4F3(8), EPHX2(7), GGT1(5), GPX2(1), GPX3(2), GPX5(6), GPX6(7), GPX7(1), LTA4H(4), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PTGDS(5), PTGES(2), PTGES2(3), PTGIS(7), PTGS1(6), PTGS2(9), TBXAS1(7) 14108848 248 66 240 73 88 90 40 5 25 0 0.0816 1.000 1.000 377 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 92 ANK2(40), B3GALT4(3), CDR1(2), DGKI(20), FAU(2), IL6ST(11), MRPL19(6), PIGK(9), RPL10(5), RPL11(3), RPL13(1), RPL13A(1), RPL14(3), RPL15(2), RPL17(6), RPL18(1), RPL18A(2), RPL19(4), RPL21(3), RPL22(5), RPL23(1), RPL24(2), RPL27(1), RPL27A(3), RPL28(3), RPL29(2), RPL3(2), RPL34(1), RPL35A(2), RPL37(3), RPL38(1), RPL39(4), RPL3L(3), RPL4(4), RPL5(7), RPL6(3), RPL7(1), RPL7A(2), RPL8(2), RPL9(2), RPLP0(5), RPS10(1), RPS11(1), RPS12(2), RPS13(1), RPS15(1), RPS16(1), RPS18(3), RPS20(3), RPS21(3), RPS24(2), RPS25(2), RPS27(1), RPS27A(4), RPS28(1), RPS29(2), RPS3(3), RPS3A(1), RPS4X(1), RPS6(7), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), RPS6KA6(19), RPS6KB1(5), RPS6KB2(4), RPS7(5), RPS8(2), RPS9(1), RPSA(1), SLC36A2(6), TBC1D10C(1), TSPAN9(4), UBA52(1), UBB(2), UBC(8) 19078569 316 66 306 109 88 117 67 3 39 2 0.911 1.000 1.000 378 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(4), AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPS(8), CDS1(5), CHAT(5), CHKA(9), CHKB(6), CLC(1), CPT1B(6), DGKA(10), DGKB(22), DGKD(18), DGKE(5), DGKG(11), DGKH(11), DGKQ(2), DGKZ(10), ETNK1(10), GNPAT(11), GPD1(3), GPD2(3), LCAT(4), LGALS13(1), LYPLA1(1), LYPLA2(7), PAFAH1B1(2), PAFAH2(2), PCYT1A(4), PCYT1B(4), PEMT(1), PISD(2), PLA2G2E(5), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLCB2(8), PLCG1(12), PLCG2(27), PPAP2A(6), PPAP2B(3), PPAP2C(1) 17808076 291 65 286 105 93 104 63 3 26 2 0.657 1.000 1.000 379 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(5), ALDOB(9), ALDOC(3), DLAT(3), DLD(5), ENO1(6), ENO2(4), ENO3(5), FBP1(2), FBP2(1), G6PC(5), GAPDH(3), GAPDHS(10), GCK(3), GOT1(9), GOT2(3), GPI(7), HK1(11), HK2(9), HK3(10), LDHA(8), LDHAL6B(2), LDHB(3), LDHC(4), MDH1(4), MDH2(4), PC(12), PCK1(9), PDHA1(7), PDHA2(9), PDHB(3), PDHX(11), PFKL(8), PFKM(9), PFKP(8), PGAM1(3), PGAM2(1), PGK1(7), PGK2(6), PKLR(7), PKM2(5), TNFAIP1(3), TPI1(2) 15179743 248 65 244 83 86 88 44 2 28 0 0.270 1.000 1.000 380 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(9), ACACA(33), ACACB(29), ACADM(9), ACAT1(6), ACAT2(4), ACSS1(5), ACSS2(6), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH6A1(6), ALDH7A1(2), ALDH9A1(2), ECHS1(3), EHHADH(11), HADHA(6), HIBCH(6), LDHA(8), LDHAL6A(8), LDHAL6B(2), LDHB(3), LDHC(4), MCEE(1), MLYCD(3), MUT(10), PCCA(6), PCCB(9), SUCLA2(5), SUCLG1(5), SUCLG2(10) 14485204 238 65 233 65 62 88 53 5 29 1 0.0971 1.000 1.000 381 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(8), AADAC(6), ABAT(9), ACADS(3), ACAT1(6), ACAT2(4), ACSM1(11), AKR1B10(4), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH5A1(7), ALDH7A1(2), ALDH9A1(2), BDH1(3), BDH2(4), DDHD1(8), ECHS1(3), EHHADH(11), GAD1(6), GAD2(12), HADH(1), HADHA(6), HMGCL(2), HMGCS1(6), HMGCS2(9), HSD17B10(4), HSD17B4(13), HSD3B7(5), ILVBL(8), L2HGDH(5), OXCT1(10), OXCT2(2), PDHA1(7), PDHA2(9), PDHB(3), PLA1A(6), PPME1(3), PRDX6(4), RDH11(1), RDH12(5), RDH13(4), RDH14(2) 14787189 251 65 242 77 77 91 50 6 26 1 0.153 1.000 1.000 382 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(5), AGMAT(3), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH4A1(4), ALDH9A1(2), AMD1(3), AOC2(7), AOC3(10), ARG1(5), ARG2(3), ASL(2), CKM(3), CKMT1A(1), CKMT2(4), CPS1(23), DAO(8), GAMT(3), GATM(5), GLUD1(3), GOT1(9), GOT2(3), MAOA(12), MAOB(7), NOS1(18), NOS3(11), OAT(7), ODC1(2), OTC(7), P4HA1(6), P4HA2(12), P4HA3(3), P4HB(6), PYCR1(3), RARS(13), SMS(8) 15728089 269 64 264 93 89 95 50 6 27 2 0.435 1.000 1.000 383 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(5), AGXT(4), AGXT2(12), ALAS1(8), ALAS2(11), AMT(2), AOC2(7), AOC3(10), ATP6V0C(1), BHMT(2), CBS(11), CHDH(2), CHKA(9), CHKB(6), CPT1B(6), CTH(6), DAO(8), DLD(5), DMGDH(4), GAMT(3), GARS(8), GATM(5), GLDC(16), MAOA(12), MAOB(7), PEMT(1), PISD(2), PLCB2(8), PLCG1(12), PLCG2(27), PSPH(1), SARDH(9), SARS(4), SHMT1(5), SHMT2(5), TARS(9) 15209542 253 64 245 89 78 100 50 0 25 0 0.560 1.000 1.000 384 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(5), ACAA2(3), ACADL(8), ACADM(9), ACADS(3), ACADSB(6), ACADVL(9), ACAT1(6), ACAT2(4), ACOX1(7), ACOX3(8), ACSL1(14), ACSL3(7), ACSL4(21), ACSL5(9), ACSL6(12), ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2), CPT1A(9), CPT1B(6), CPT1C(15), CPT2(4), CYP4A11(7), CYP4A22(7), ECHS1(3), EHHADH(11), GCDH(6), HADH(1), HADHA(6), HADHB(4), HSD17B10(4), HSD17B4(13) 17830726 298 64 292 80 85 108 66 2 37 0 0.0202 1.000 1.000 385 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(4), ALPL(5), ALPP(3), ALPPL2(3), ASCC3(31), ATP13A2(5), DDX18(12), DDX19A(4), DDX23(9), DDX4(15), DDX41(3), DDX47(5), DDX50(10), DDX51(8), DDX52(4), DDX54(8), DDX55(7), DDX56(5), DHFR(5), DHX58(6), ENTPD7(8), EP400(42), ERCC2(1), ERCC3(11), FPGS(5), GCH1(1), GGH(2), IFIH1(5), MOV10L1(19), NUDT5(2), NUDT8(1), PTS(1), RAD54B(14), RAD54L(5), RUVBL2(4), SETX(33), SKIV2L2(17), SMARCA2(24), SMARCA5(19), SPR(1) 22546741 367 64 352 98 127 112 83 4 35 6 0.0284 1.000 1.000 386 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(9), ADC(8), ALDH4A1(4), ALDH5A1(7), CAD(25), CPS1(23), EARS2(5), EPRS(15), GAD1(6), GAD2(12), GCLC(8), GCLM(2), GFPT1(9), GFPT2(12), GLS(11), GLS2(7), GLUD1(3), GLUD2(9), GLUL(7), GMPS(14), GNPNAT1(2), GOT1(9), GOT2(3), GPT(2), GPT2(5), GSR(6), GSS(5), NADSYN1(6), NAGK(2), PPAT(9), QARS(7) 14398876 252 63 246 79 81 79 48 4 38 2 0.276 1.000 1.000 387 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(8), AARS2(7), ABAT(9), ACY3(3), ADSL(8), ADSS(6), ADSSL1(5), AGXT(4), AGXT2(12), ASL(2), ASNS(9), ASPA(5), ASS1(2), CAD(25), CRAT(3), DARS(7), DARS2(10), DDO(7), DLAT(3), DLD(5), GAD1(6), GAD2(12), GOT1(9), GOT2(3), GPT(2), GPT2(5), NARS(11), NARS2(10), PC(12), PDHA1(7), PDHA2(9), PDHB(3) 13551574 229 63 223 79 57 95 41 5 31 0 0.552 1.000 1.000 388 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 28 AGA(7), ARSB(5), FUCA1(3), FUCA2(4), GALNS(4), GBA(4), GLB1(6), GNS(5), GUSB(5), HEXA(3), HEXB(5), HGSNAT(9), HPSE(6), HPSE2(11), HYAL1(2), HYAL2(4), IDS(8), IDUA(7), LCT(32), MAN2B1(14), MAN2B2(5), MAN2C1(7), MANBA(12), NAGLU(3), NEU2(4), NEU3(3), SPAM1(15) 11933424 193 63 192 78 50 82 36 4 21 0 0.880 1.000 1.000 389 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(1), AKR1B10(4), ALDOA(5), ALDOB(9), ALDOC(3), FBP1(2), FBP2(1), FPGT(6), FUK(8), GMDS(4), GMPPA(6), GMPPB(2), HK1(11), HK2(9), HK3(10), HSD3B7(5), KHK(2), LHPP(2), MPI(5), MTMR1(16), MTMR2(5), MTMR6(10), PFKFB1(8), PFKFB2(4), PFKFB3(4), PFKFB4(4), PFKL(8), PFKM(9), PFKP(8), PGM2(8), PHPT1(1), PMM2(6), RDH11(1), RDH12(5), RDH13(4), RDH14(2), SORD(5), TPI1(2), TSTA3(4) 13401284 209 62 204 79 78 62 36 3 30 0 0.622 1.000 1.000 390 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(5), AGXT(4), AGXT2(12), AKR1B10(4), ALAS1(8), ALAS2(11), AMT(2), AOC2(7), AOC3(10), BHMT(2), CBS(11), CHDH(2), CHKA(9), CHKB(6), CTH(6), DAO(8), DLD(5), DMGDH(4), GAMT(3), GARS(8), GATM(5), GLDC(16), GNMT(3), HSD3B7(5), MAOA(12), MAOB(7), PEMT(1), PHGDH(5), PIPOX(4), PISD(2), PSAT1(5), PSPH(1), RDH11(1), RDH12(5), RDH13(4), RDH14(2), SARDH(9), SARS(4), SARS2(6), SDS(1), SHMT1(5), SHMT2(5), TARS(9), TARS2(10) 15514922 254 62 247 98 79 102 46 1 26 0 0.783 1.000 1.000 391 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 40 ABP1(5), ACY3(3), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH3B2(7), ALDH7A1(2), ALDH9A1(2), AMDHD1(13), AOC2(7), AOC3(10), ASPA(5), CARM1(5), CNDP1(4), DDC(9), FTCD(8), HAL(6), HARS(5), HARS2(7), HDC(9), HEMK1(3), HNMT(4), LCMT1(2), LCMT2(9), MAOA(12), MAOB(7), METTL2B(4), METTL6(5), PRMT2(4), PRMT3(9), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), PRPS1(3), PRPS2(7), UROC1(9), WBSCR22(5) 13908656 244 62 236 80 71 92 45 4 32 0 0.259 1.000 1.000 392 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(2), ALG10(6), ALG10B(6), ALG11(6), ALG12(7), ALG13(24), ALG14(2), ALG2(2), ALG3(1), ALG5(2), ALG6(5), ALG8(10), ALG9(4), B4GALT1(2), B4GALT2(5), B4GALT3(10), DAD1(2), DDOST(3), DHDDS(4), DOLPP1(2), DPAGT1(3), DPM1(2), FUT8(13), GANAB(10), MAN1A1(13), MAN1A2(7), MAN1B1(5), MAN1C1(6), MAN2A1(20), MGAT1(4), MGAT2(4), MGAT3(4), MGAT4A(5), MGAT4B(6), MGAT5(11), MGAT5B(10), RFT1(6), RPN1(3), RPN2(5), ST6GAL1(7), STT3B(5) 15130995 254 62 239 64 82 85 55 1 30 1 0.0234 1.000 1.000 393 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 29 B4GALT5(2), C1GALT1(2), C1GALT1C1(6), GALNT1(10), GALNT10(8), GALNT11(12), GALNT12(6), GALNT13(18), GALNT14(6), GALNT2(9), GALNT3(7), GALNT4(8), GALNT5(5), GALNT6(1), GALNT7(13), GALNT8(11), GALNT9(8), GALNTL1(8), GALNTL2(17), GALNTL4(6), GALNTL5(11), GCNT1(5), GCNT3(5), GCNT4(1), OGT(17), ST3GAL1(2), ST3GAL2(6), ST6GALNAC1(4), WBSCR17(15) 11810588 229 62 223 80 62 86 48 1 31 1 0.787 1.000 1.000 394 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(2), ALOX12(8), ALOX15(9), ALOX5(10), CBR1(4), CBR3(2), CYP4F2(12), CYP4F3(8), EPX(15), GGT1(5), LPO(6), LTA4H(4), MPO(10), PLA2G2E(5), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PRDX2(4), PRDX5(1), PRDX6(4), PTGDS(5), PTGES2(3), PTGIS(7), PTGS1(6), PTGS2(9), TBXAS1(7), TPO(15) 10064017 191 62 183 60 77 65 28 5 16 0 0.172 1.000 1.000 395 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 34 AKT1(4), ATF1(6), CDC42(4), CREB1(6), CREB5(5), DUSP1(2), DUSP10(5), EEF2K(11), EIF4E(2), ELK1(3), IL1R1(5), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP3K10(7), MAP3K4(21), MAP3K5(25), MAP3K7(9), MAPK1(2), MAPK11(3), MAPK12(3), MAPK13(4), MAPK14(4), MAPKAPK2(6), MAPKAPK5(5), MKNK1(3), MKNK2(3), MYEF2(6), NFKB1(10), NR2C2(7), SRF(3), TRAF6(7) 11929413 207 61 204 59 70 75 40 1 21 0 0.141 1.000 1.000 396 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 46 APAF1(17), BAD(2), BAX(3), BCL2L1(4), BCL2L2(2), BOK(2), CASP1(8), CASP10(8), CASP2(6), CASP3(4), CASP4(5), CASP6(7), CASP7(4), CASP8(21), CASP9(3), CD40(4), CD40LG(6), CRADD(3), CYCS(2), DAXX(10), DFFB(4), FADD(1), FAS(9), FASLG(7), IKBKE(4), LTA(3), MCL1(1), NFKB1(10), NFKBIA(3), NGFR(3), NR3C1(18), NTRK1(13), PTPN13(30), RIPK1(9), TFG(4), TNFRSF1A(4), TNFRSF1B(2), TRAF1(5), TRAF2(3), TRAF3(5), TRAF6(7) 15655494 266 60 260 78 59 107 51 2 47 0 0.273 1.000 1.000 397 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM1(2), CALM2(4), CAMK1(2), CAMK1G(5), ELK1(3), FPR1(2), GNA15(1), GNB1(2), GNGT1(1), HRAS(1), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K6(10), MAP3K1(30), MAPK1(2), MAPK14(4), MAPK3(3), NCF1(3), NCF2(8), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(5), NFKB1(10), NFKBIA(3), PAK1(3), PIK3C2G(16), PLCB1(5), PPP3CA(4), PPP3CB(5), PPP3CC(6), RAC1(1), RAF1(8), RELA(6), SYT1(4) 13841989 208 60 203 68 63 73 40 2 29 1 0.410 1.000 1.000 398 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(1), B4GALT1(2), B4GALT2(5), FBP2(1), G6PC(5), GAA(4), GALE(1), GALK1(1), GALK2(3), GALT(3), GANAB(10), GCK(3), GLA(9), GLB1(6), HK1(11), HK2(9), HK3(10), LALBA(2), LCT(32), MGAM(51), PFKM(9), PFKP(8), PGM1(7), PGM3(4) 11638492 197 60 194 83 64 73 37 2 21 0 0.913 1.000 1.000 399 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(4), ARG1(5), ARG2(3), ASL(2), ASS1(2), CKM(3), CKMT1A(1), CKMT2(4), CPS1(23), DAO(8), EPRS(15), GAMT(3), GATM(5), GLUD1(3), GLUD2(9), GOT1(9), GOT2(3), LAP3(10), NOS1(18), NOS3(11), OAT(7), OTC(7), P4HA1(6), P4HA2(12), P4HA3(3), PARS2(4), PRODH(12), PYCR1(3), PYCR2(2), PYCRL(1), RARS(13), RARS2(8) 12782303 219 60 215 79 72 81 39 5 20 2 0.676 1.000 1.000 400 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(3), GTF2A1L(3), GTF2B(5), GTF2E1(3), GTF2E2(2), GTF2F1(7), GTF2F2(1), GTF2H1(9), GTF2H3(3), GTF2H4(2), GTF2I(4), GTF2IRD1(7), STON1(1), TAF1(57), TAF10(1), TAF1L(40), TAF2(19), TAF4(10), TAF4B(4), TAF5(8), TAF5L(5), TAF6(9), TAF6L(5), TAF7(4), TAF7L(10), TAF9(4), TAF9B(12), TBPL1(5), TBPL2(5) 12968048 248 60 241 59 83 95 43 3 23 1 0.0409 1.000 1.000 401 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(12), ADRBK2(15), ARRB2(4), CALM1(2), CALM2(4), CALML3(3), CALML6(4), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CLCA1(15), CLCA2(10), CLCA4(15), CNGA3(13), CNGA4(10), CNGB1(13), GNAL(6), GUCA1A(5), GUCA1B(3), GUCA1C(5), PDC(1), PDE1C(12), PRKACA(6), PRKACB(3), PRKACG(9), PRKG1(11), PRKG2(11), PRKX(2) 11219988 216 60 212 73 67 82 34 2 31 0 0.387 1.000 1.000 402 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(8), CREBBP(32), DUSP1(2), EP300(32), IKBKB(13), IL1B(2), IL8(3), MAP2K3(7), MAP2K6(10), MAP3K14(6), MAP3K7(9), MAPK11(3), MAPK14(4), MYD88(3), NFKB1(10), NFKBIA(3), NR3C1(18), RELA(6), TGFBR1(5), TGFBR2(6), TLR2(16) 10691056 198 60 191 51 57 64 43 2 30 2 0.0916 1.000 1.000 403 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(8), BCR(6), BLNK(4), ELK1(3), FOS(3), GRB2(3), HRAS(1), JUN(1), LYN(9), MAP2K1(2), MAP3K1(30), MAPK1(2), MAPK3(3), MAPK8IP3(9), PAPPA(27), RAC1(1), RPS6KA1(1), RPS6KA3(19), SHC1(7), SOS1(13), SYK(4), VAV1(12), VAV2(7), VAV3(14) 11251667 189 60 183 58 52 71 38 1 26 1 0.277 1.000 1.000 404 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(9), ABP1(5), ACADL(8), ACADM(9), ACADSB(6), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH9A1(2), AOC2(7), AOC3(10), CNDP1(4), DPYD(20), DPYS(6), ECHS1(3), EHHADH(11), GAD1(6), GAD2(12), HADHA(6), MLYCD(3), SDS(1), SMS(8), UPB1(10) 10447050 194 59 191 71 50 68 49 3 24 0 0.554 1.000 1.000 405 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 DPM2(2), EGFR(12), ELK1(3), GNAS(24), GNB1(2), GNGT1(1), GRB2(3), HRAS(1), IGF1R(13), ITGB1(8), KLK2(2), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), MKNK1(3), MKNK2(3), MYC(8), NGFR(3), PDGFRA(24), PPP2CA(6), PTPRR(17), RAF1(8), RPS6KA1(1), RPS6KA5(11), SHC1(7), SOS1(13), SRC(3), STAT3(10) 11799432 200 59 191 50 55 77 43 1 23 1 0.0273 1.000 1.000 406 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(9), ACACA(33), ACADL(8), ACADM(9), ACADSB(6), ACAT1(6), ACAT2(4), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH6A1(6), ALDH9A1(2), ECHS1(3), EHHADH(11), HADHA(6), LDHA(8), LDHB(3), LDHC(4), MCEE(1), MLYCD(3), MUT(10), PCCA(6), PCCB(9), SDS(1), SUCLA2(5), SUCLG1(5), SUCLG2(10) 12101964 216 59 213 59 49 76 54 4 33 0 0.148 1.000 1.000 407 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), DAG1(6), ITPKA(1), ITPKB(11), ITPR1(34), ITPR2(35), ITPR3(21), NFAT5(16), PDE6A(10), PDE6B(5), PDE6C(13), PDE6D(2), PDE6G(1), PDE6H(1), SLC6A13(9), TF(14) 13059603 201 59 199 70 57 86 25 1 31 1 0.344 1.000 1.000 408 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(14), F11(15), F12(2), F13B(15), F2(8), F5(48), F7(2), F8(45), F9(14), FGA(26), FGB(7), FGG(10), LPA(15), PLAT(6), PLAU(6), PLG(14), SERPINB2(9), SERPINE1(5), SERPINF2(4), VWF(25) 12712243 290 58 274 76 69 134 52 0 35 0 0.0448 1.000 1.000 409 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 31 APAF1(17), BID(2), BIRC2(10), BIRC3(5), CASP10(8), CASP3(4), CASP6(7), CASP7(4), CASP8(21), CASP9(3), CFLAR(6), CHUK(8), CYCS(2), DFFB(4), FADD(1), GAS2(7), LMNA(7), MAP3K14(6), NFKB1(10), NFKBIA(3), RELA(6), RIPK1(9), SPTAN1(31), TNFRSF10A(2), TNFRSF10B(5), TNFRSF25(3), TNFSF10(1), TNFSF12(4), TRAF2(3) 11978937 199 58 193 51 50 80 24 3 42 0 0.104 1.000 1.000 410 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 ATM(54), BMPR1B(6), CCND2(9), CDK4(3), CDKN1B(7), DAZL(6), DMC1(5), EGR1(6), ESR2(5), FSHR(16), GJA4(1), INHA(1), LHCGR(17), MLH1(7), MSH5(10), NCOR1(23), NR5A1(3), NRIP1(17), PGR(13), PRLR(5), PTGER2(3), SMPD1(11), VDR(8), ZP2(12) 12345156 248 58 238 65 51 98 40 6 49 4 0.174 1.000 1.000 411 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 36 ACACA(33), ACAT1(6), ACAT2(4), ACYP1(2), AKR1B1(1), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH9A1(2), DLAT(3), DLD(5), GRHPR(3), LDHA(8), LDHB(3), LDHC(4), LDHD(2), MDH1(4), MDH2(4), ME1(12), ME2(8), ME3(9), PC(12), PCK1(9), PDHA1(7), PDHA2(9), PDHB(3), PKLR(7), PKM2(5) 13180165 213 58 209 69 64 78 38 4 29 0 0.395 1.000 1.000 412 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(5), ACAA2(3), ACADL(8), ACADM(9), ACADS(3), ACADSB(6), ACAT1(6), ACAT2(4), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH6A1(6), ALDH9A1(2), AOX1(18), BCAT1(7), BCKDHA(6), BCKDHB(3), ECHS1(3), EHHADH(11), HADHA(6), HADHB(4), HIBADH(5), HMGCL(2), IVD(2), MCCC1(9), MCCC2(5), MCEE(1), MUT(10), OXCT1(10), PCCA(6), PCCB(9), SDS(1) 13157737 218 58 215 70 53 84 51 2 28 0 0.383 1.000 1.000 413 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(11), ACO1(17), ACO2(7), CLYBL(9), CS(6), DLD(5), DLST(9), FH(8), IDH1(4), IDH2(5), IDH3A(3), IDH3B(3), IDH3G(10), MDH1(4), MDH2(4), OGDH(13), OGDHL(19), PC(12), PCK1(9), PCK2(7), SDHA(15), SDHB(2), SDHC(4), SDHD(3), SUCLA2(5), SUCLG1(5), SUCLG2(10) 10928355 209 57 204 70 82 63 40 4 20 0 0.229 1.000 1.000 414 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(56), ASAH1(7), CAMP(1), CASP3(4), CERK(6), CREB1(6), CREB5(5), CXCL2(2), DAG1(6), EPHB2(12), FOS(3), GNAQ(3), ITPKA(1), ITPKB(11), JUN(1), MAP2K4(9), MAP2K7(4), MAPK1(2), MAPK10(9), MAPK8(10), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(9), MAPK9(5) 9812900 177 57 173 60 48 68 20 1 36 4 0.433 1.000 1.000 415 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(2), CALM2(4), CHUK(8), EGR2(6), EGR3(7), GNAQ(3), MAP3K1(30), MYC(8), NFATC1(10), NFATC2(13), NFKB1(10), NFKBIA(3), PLCG1(12), PPP3CA(4), PPP3CB(5), PPP3CC(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), RELA(6), SYT1(4), VIP(3), VIPR2(4) 9816248 175 57 170 56 49 66 32 2 24 2 0.311 1.000 1.000 416 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(8), ABAT(9), ADSL(8), ADSS(6), AGXT(4), AGXT2(12), ASL(2), ASNS(9), ASPA(5), CAD(25), CRAT(3), DARS(7), DDO(7), GAD1(6), GAD2(12), GOT1(9), GOT2(3), GPT(2), GPT2(5), NARS(11), PC(12) 9296781 165 56 161 53 44 64 29 4 24 0 0.335 1.000 1.000 417 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(9), ALDH4A1(4), ALDH5A1(7), CAD(25), CPS1(23), EPRS(15), GAD1(6), GAD2(12), GCLC(8), GCLM(2), GFPT1(9), GLS(11), GLS2(7), GLUD1(3), GLUL(7), GMPS(14), GOT1(9), GOT2(3), GPT(2), GPT2(5), GSS(5), NADSYN1(6), PPAT(9), QARS(7) 12092421 208 56 202 63 58 68 44 4 32 2 0.322 1.000 1.000 418 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 35 ARSA(2), ARSD(6), ARSE(10), ASAH1(7), B4GALT6(6), CERK(6), DEGS1(5), DEGS2(4), ENPP7(3), GAL3ST1(7), GALC(8), GBA(4), GLA(9), GLB1(6), LCT(32), NEU2(4), NEU3(3), PPAP2A(6), PPAP2B(3), PPAP2C(1), SGMS1(5), SGMS2(5), SGPP1(2), SGPP2(4), SMPD1(11), SMPD2(7), SMPD3(7), SMPD4(8), SPHK1(2), SPHK2(2), SPTLC1(6), SPTLC2(5), UGCG(4), UGT8(14) 12070767 214 56 209 63 56 98 32 3 25 0 0.0610 1.000 1.000 419 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(8), IFNA1(2), IFNB1(3), IKBKB(13), IL1B(2), IL1R1(5), IL1RAP(8), IL6(5), IRAK1(4), IRAK2(9), IRAK3(10), JUN(1), MAP2K3(7), MAP2K6(10), MAP3K1(30), MAP3K14(6), MAP3K7(9), MAPK14(4), MAPK8(10), MYD88(3), NFKB1(10), NFKBIA(3), RELA(6), TGFB1(2), TGFB2(5), TGFB3(9), TOLLIP(1), TRAF6(7) 10714977 192 56 188 44 42 80 37 1 30 2 0.0440 1.000 1.000 420 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(7), CDK7(7), ERCC3(11), GTF2B(5), GTF2E1(3), GTF2E2(2), GTF2F2(1), GTF2H1(9), GTF2H4(2), ILK(5), POLR1A(16), POLR1B(16), POLR2A(21), POLR2B(21), POLR2C(5), POLR2E(1), POLR2F(2), POLR2H(3), POLR2J(1), POLR2K(2), POLR3B(14), POLR3D(3), POLR3E(5), POLR3H(5), TAF5(8), TAF6(9), TAF7(4), TAF9(4), TBP(3) 12564504 195 56 193 58 73 66 29 3 23 1 0.272 1.000 1.000 421 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(6), BAD(2), BRAF(10), CREB1(6), CREB5(5), DUSP6(2), DUSP9(1), EEF2K(11), EIF4E(2), GRB2(3), MAP2K1(2), MAP2K2(5), MAP3K8(10), MAPK1(2), MAPK3(3), MKNK1(3), MKNK2(3), MOS(6), NFKB1(10), RAP1A(4), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), SHC1(7), SOS1(13), SOS2(17), TRAF3(5) 10740371 172 56 168 59 51 63 37 1 19 1 0.553 1.000 1.000 422 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(12), DLG4(11), EPHB2(12), F2(8), F2RL1(4), F2RL2(2), JUN(1), MAP2K5(3), MAPK1(2), MAPK7(14), MAPK8(10), MYEF2(6), PLD1(14), PLD2(10), PLD3(5), PTK2(12), RAF1(8), RASAL1(14), SRC(3), TEC(8), VAV1(12) 10013158 171 56 168 61 59 54 29 3 26 0 0.692 1.000 1.000 423 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(21), CALM1(2), CALM2(4), CREB1(6), ELK1(3), FOS(3), GNAI1(5), GNAQ(3), GNAS(24), GNB1(2), GNGT1(1), HRAS(1), JUN(1), MAP2K1(2), MAPK3(3), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(5), PLCG1(12), PPP3CA(4), PPP3CB(5), PPP3CC(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(10), RAF1(8), RPS6KA3(19), SYT1(4) 12116635 216 55 208 74 80 66 42 1 26 1 0.372 1.000 1.000 424 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(9), ABP1(5), ACADM(9), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2), AOC2(7), AOC3(10), CNDP1(4), DPYD(20), DPYS(6), ECHS1(3), EHHADH(11), GAD1(6), GAD2(12), HADHA(6), HIBCH(6), MLYCD(3), SMS(8), SRM(1), UPB1(10) 9640368 167 55 164 56 45 61 40 3 18 0 0.334 1.000 1.000 425 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(9), ELK1(3), FOS(3), GRB2(3), HRAS(1), IL2(2), IL2RA(4), IL2RB(3), IL2RG(13), JAK1(20), JAK3(10), JUN(1), LCK(5), MAP2K1(2), MAPK3(3), MAPK8(10), RAF1(8), SHC1(7), SOS1(13), STAT5A(5), STAT5B(7), SYK(4) 8425585 136 55 130 35 35 56 26 2 17 0 0.0659 1.000 1.000 426 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(6), AASDH(10), AASDHPPT(9), AASS(12), ACAT1(6), ACAT2(4), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH9A1(2), ATP6V0C(1), BBOX1(1), DLST(9), DOT1L(8), ECHS1(3), EHHADH(11), EHMT1(23), EHMT2(2), GCDH(6), HADHA(6), PLOD1(4), PLOD2(13), PLOD3(7), SDS(1), SHMT1(5), SHMT2(5), TMLHE(6) 12530482 208 55 203 71 66 71 44 5 21 1 0.312 1.000 1.000 427 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(4), AP2A1(7), AP2M1(8), ARF1(3), BAD(2), BTK(12), EEA1(17), GRASP(4), GSK3A(10), GSK3B(13), LYN(9), PDPK1(3), PFKL(8), PFKM(9), PFKP(8), PLCG1(12), PRKCE(10), PRKCZ(3), RAB5A(2), RAC1(1), RPS6KB1(5), VAV2(7) 8954356 157 55 152 55 62 53 25 0 17 0 0.435 1.000 1.000 428 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(6), CASP2(6), CHUK(8), CRADD(3), IKBKB(13), IKBKG(4), JUN(1), LTA(3), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP3K1(30), MAP3K14(6), MAP4K2(7), MAPK14(4), MAPK8(10), NFKB1(10), NFKBIA(3), RELA(6), RIPK1(9), TANK(5), TNFRSF1A(4), TRAF2(3) 8545840 167 54 165 42 37 62 34 1 31 2 0.105 1.000 1.000 429 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(5), ALDOB(9), ALDOC(3), DERA(10), FBP1(2), FBP2(1), G6PD(6), GPI(7), H6PD(7), PFKL(8), PFKM(9), PFKP(8), PGD(3), PGLS(2), PGM1(7), PGM3(4), PRPS1(3), PRPS1L1(5), PRPS2(7), RBKS(1), RPE(5), RPIA(9), TALDO1(6), TKT(6), TKTL1(9), TKTL2(16) 8567433 158 53 151 50 64 49 23 1 21 0 0.107 1.000 1.000 430 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 37 ACAA1(5), ACAA2(3), ACAD8(5), ACAD9(8), ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), AKR1B10(4), AKR1C4(6), AKR1D1(8), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2), BAAT(7), CEL(5), CYP27A1(9), CYP7A1(11), HADHB(4), HSD3B7(5), LIPA(8), RDH11(1), RDH12(5), RDH13(4), RDH14(2), SLC27A5(3), SOAT1(9), SOAT2(5), SRD5A1(6) 11346074 194 53 191 63 66 67 35 4 21 1 0.205 1.000 1.000 431 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(4), ALOX15(9), ALOX5(10), CYP1A2(11), CYP2C18(5), CYP2C19(6), CYP2C8(7), CYP2C9(5), CYP2E1(2), CYP2J2(5), CYP3A4(10), CYP3A43(4), CYP3A5(6), CYP3A7(7), HSD3B7(5), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), RDH11(1), RDH12(5), RDH13(4), RDH14(2) 8757420 153 53 148 46 47 58 23 4 21 0 0.226 1.000 1.000 432 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(3), ALAS1(8), ALAS2(11), BLVRA(1), BLVRB(1), COX10(3), COX15(3), CP(15), CPOX(6), EARS2(5), EPRS(15), FECH(7), FTH1(2), FTMT(7), GUSB(5), HCCS(1), HMBS(8), HMOX1(4), HMOX2(3), MMAB(2), UGT1A1(6), UGT1A10(7), UGT1A3(2), UGT1A4(5), UGT1A5(7), UGT1A6(3), UGT1A7(7), UGT1A8(5), UGT1A9(3), UGT2A1(11), UGT2A3(5), UGT2B10(18), UGT2B11(18), UGT2B15(9), UGT2B17(7), UGT2B28(21), UGT2B4(11), UGT2B7(5), UROD(3), UROS(3) 15055211 266 53 253 68 72 118 46 2 28 0 0.0492 1.000 1.000 433 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(7), CS(6), DLAT(3), DLD(5), DLST(9), FH(8), IDH2(5), IDH3A(3), IDH3B(3), IDH3G(10), MDH1(4), MDH2(4), OGDH(13), PC(12), PDHA1(7), PDHA2(9), PDHB(3), PDHX(11), PDK1(2), PDK2(5), PDK3(12), PDK4(10), PDP2(4), SDHA(15), SDHB(2), SDHC(4), SDHD(3), SUCLA2(5), SUCLG1(5), SUCLG2(10) 10367375 199 53 196 65 70 69 35 2 23 0 0.310 1.000 1.000 434 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(8), CARS(9), DARS(7), EPRS(15), FARS2(2), GARS(8), HARS(5), IARS(8), KARS(5), LARS(18), LARS2(8), MARS(11), MARS2(4), NARS(11), QARS(7), RARS(13), SARS(4), TARS(9), WARS(6), WARS2(3), YARS(5) 11765558 166 52 163 61 46 72 31 1 16 0 0.898 1.000 1.000 435 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 38 ARNTL(10), AZIN1(8), CBX3(4), CLOCK(9), CRY1(9), CRY2(3), DNAJA1(3), EIF4G2(7), ETV6(6), GFRA1(9), GSTM3(5), GSTP1(2), HERPUD1(2), HSPA8(8), IDI1(3), KLF9(3), MYF6(8), NCKAP1(8), NCOA4(8), NR1D2(2), PER1(10), PER2(13), PIGF(2), PPP1R3C(4), PPP2CB(4), PSMA4(2), SF3A3(8), SUMO3(3), TOB1(4), TUBB3(6), UGP2(6), VAPA(6), ZFR(10) 13167207 195 52 190 59 62 71 38 2 22 0 0.382 1.000 1.000 436 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 25 ABP1(5), ALDH1A3(8), ALDH3A1(7), ALDH3B2(7), AOC2(7), AOC3(10), DDC(9), EPX(15), ESCO1(16), ESCO2(8), GOT1(9), GOT2(3), HPD(2), LPO(6), MAOA(12), MAOB(7), MPO(10), NAT6(1), PNPLA3(7), PRDX6(4), SH3GLB1(7), TAT(7), TPO(15) 12074023 182 52 178 62 59 67 34 3 19 0 0.457 1.000 1.000 437 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(5), CHIA(3), CHIT1(6), CMAS(7), CTBS(4), CYB5R1(3), CYB5R3(5), GFPT1(9), GFPT2(12), GNE(10), GNPDA1(2), GNPDA2(10), GNPNAT1(2), HEXA(3), HEXB(5), HK1(11), HK2(9), HK3(10), LHPP(2), MTMR1(16), MTMR2(5), MTMR6(10), NAGK(2), NANS(7), NPL(7), PGM3(4), PHPT1(1), RENBP(4), UAP1(6) 10429868 180 52 178 54 56 57 37 1 29 0 0.273 1.000 1.000 438 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(30), APOA1(3), APOA4(3), APOC1(3), APOC3(1), APOE(1), CETP(5), CYP7A1(11), DGAT1(3), HMGCR(12), LCAT(4), LDLR(6), LIPC(8), LPL(16), LRP1(51), SCARB1(7), SOAT1(9) 9737188 173 52 170 47 67 54 36 0 16 0 0.0334 1.000 1.000 439 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(5), ACTN1(9), ACTN2(16), ACTN3(10), CAPN1(5), CAPNS1(2), CAPNS2(3), ITGA1(17), ITGB1(8), ITGB3(11), PTK2(12), PXN(6), RAC1(1), SPTAN1(31), SRC(3), TLN1(23) 10471567 162 52 159 61 67 47 23 1 24 0 0.667 1.000 1.000 440 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(8), ABAT(9), ACADS(3), ACAT1(6), ACAT2(4), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH5A1(7), ALDH9A1(2), ECHS1(3), EHHADH(11), GAD1(6), GAD2(12), HADHA(6), HMGCL(2), L2HGDH(5), OXCT1(10), PDHA1(7), PDHA2(9), PDHB(3), SDHB(2), SDS(1) 9314002 164 51 160 48 47 59 36 3 19 0 0.120 1.000 1.000 441 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(5), CREB1(6), CREBBP(32), EP300(32), NCOA3(10), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), RARA(2), RXRA(3) 7436105 117 51 112 32 30 37 24 3 21 2 0.157 1.000 1.000 442 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(5), ACP2(1), ACP5(5), ACPP(5), ACPT(5), ALPI(4), ALPL(5), ALPP(3), ALPPL2(3), CYP19A1(13), CYP1A1(12), CYP1A2(11), CYP2A13(8), CYP2A6(11), CYP2A7(5), CYP2B6(14), CYP2C18(5), CYP2C19(6), CYP2C8(7), CYP2C9(5), CYP2D6(2), CYP2E1(2), CYP2F1(4), CYP2J2(5), CYP3A4(10), CYP3A5(6), CYP3A7(7), CYP4B1(4), CYP4F8(7), CYP51A1(4), PON1(12) 10550838 196 51 192 73 60 77 37 1 19 2 0.659 1.000 1.000 443 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(20), GABBR1(12), GPRC5A(7), GPRC5B(6), GPRC5C(3), GPRC5D(4), GRM1(29), GRM2(9), GRM3(19), GRM4(12), GRM5(27), GRM7(20), GRM8(19) 7056881 187 51 179 65 61 69 31 3 21 2 0.166 1.000 1.000 444 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(16), AP2A1(7), AP2M1(8), BIN1(3), CALM1(2), CALM2(4), DNM1(4), EPN1(9), EPS15(11), NME1(2), PICALM(11), PPP3CA(4), PPP3CB(5), PPP3CC(6), SYNJ1(29), SYNJ2(11), SYT1(4) 8178295 136 51 132 51 47 44 26 0 19 0 0.625 1.000 1.000 445 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(21), CD3D(6), CD3E(2), CD3G(3), CD4(6), CREBBP(32), CSK(1), GNAS(24), GNB1(2), GNGT1(1), HLA-DRA(1), LCK(5), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PTPRC(17), ZAP70(8) 7957941 156 50 150 53 55 53 24 1 21 2 0.378 1.000 1.000 446 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(21), CD3D(6), CD3E(2), CD3G(3), CD4(6), CREBBP(32), CSK(1), GNAS(24), GNB1(2), GNGT1(1), HLA-DRA(1), LCK(5), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PTPRC(17), ZAP70(8) 7957941 156 50 150 53 55 53 24 1 21 2 0.378 1.000 1.000 447 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(5), ACY1(3), ADC(8), AGMAT(3), ALDH18A1(9), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2), AMD1(3), AOC2(7), AOC3(10), ARG1(5), ARG2(3), ASL(2), ASS1(2), CPS1(23), GATM(5), MAOA(12), MAOB(7), NAGS(3), ODC1(2), OTC(7), SAT1(5), SAT2(1), SMS(8), SRM(1) 10557702 165 50 162 68 52 60 29 3 19 2 0.858 1.000 1.000 448 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(5), CAPN1(5), CAPN2(11), CAPNS1(2), CAPNS2(3), CXCR3(5), EGF(19), EGFR(12), HRAS(1), ITGA1(17), ITGB1(8), MAPK1(2), MAPK3(3), MYL2(2), MYLK(14), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PTK2(12), PXN(6), TLN1(23) 12110743 177 50 174 55 64 53 35 1 23 1 0.147 1.000 1.000 449 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(17), ACO2(7), CS(6), DLD(5), DLST(9), FH(8), IDH1(4), IDH2(5), IDH3A(3), IDH3B(3), IDH3G(10), MDH1(4), MDH2(4), PC(12), PCK1(9), SDHA(15), SDHB(2), SUCLA2(5), SUCLG1(5), SUCLG2(10) 7507343 143 49 141 50 61 42 24 2 14 0 0.330 1.000 1.000 450 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(14), ACE2(22), AGT(8), AGTR1(4), AGTR2(11), ANPEP(15), CMA1(2), CPA3(5), CTSA(9), CTSG(3), ENPEP(19), LNPEP(10), MAS1(3), MME(11), NLN(4), REN(4), THOP1(3) 7592031 147 49 143 51 34 62 34 2 14 1 0.528 1.000 1.000 451 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(8), BAIAP2(5), CASP1(8), CASP3(4), CASP7(4), CASP8(21), GAPDH(3), INS(3), INSR(18), ITCH(10), MAGI1(23), MAGI2(28), RERE(17), WWP1(19), WWP2(9) 8511067 180 49 174 54 55 59 36 1 28 1 0.323 1.000 1.000 452 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(2), CALM2(4), DLG4(11), GRIN1(4), GRIN2A(25), GRIN2B(25), GRIN2C(6), GRIN2D(5), NOS1(18), PPP3CA(4), PPP3CB(5), PPP3CC(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(10), SYT1(4) 9115431 156 49 153 76 54 51 33 1 16 1 0.969 1.000 1.000 453 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(5), BIRC2(10), BIRC3(5), CASP3(4), CASP8(21), CFLAR(6), FADD(1), IKBKG(4), JUN(1), MAP2K4(9), MAP3K3(9), MAP3K7(9), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NFKBIL1(2), NR2C2(7), RALBP1(6), RIPK1(9), TNFAIP3(3), TNFRSF1A(4), TNFRSF1B(2), TRAF2(3) 9349804 149 49 146 38 38 60 24 0 25 2 0.102 1.000 1.000 454 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 29 AKR1C4(6), AKR1D1(8), ARSB(5), ARSD(6), ARSE(10), CYP11B1(8), CYP11B2(8), HSD11B1(6), HSD17B2(2), HSD17B3(6), HSD17B8(2), HSD3B1(3), HSD3B2(6), SRD5A1(6), STS(8), SULT1E1(9), SULT2A1(7), UGT1A1(6), UGT1A10(7), UGT1A3(2), UGT1A4(5), UGT1A5(7), UGT1A6(3), UGT1A7(7), UGT1A8(5), UGT1A9(3), UGT2B15(9), UGT2B4(11) 9754557 171 48 165 55 45 81 27 2 16 0 0.297 1.000 1.000 455 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 22 ARSA(2), ARSB(5), ARSD(6), ARSE(10), ASAH1(7), GAL3ST1(7), GALC(8), GBA(4), GLA(9), GLB1(6), LCT(32), NEU2(4), NEU3(3), PPAP2A(6), PPAP2B(3), PPAP2C(1), SMPD1(11), SMPD2(7), SPTLC1(6), SPTLC2(5), UGCG(4) 8264638 146 48 143 46 37 71 24 1 13 0 0.256 1.000 1.000 456 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(6), CARM1(5), CBS(11), CTH(6), GGT1(5), HEMK1(3), LCMT1(2), LCMT2(9), MARS(11), MARS2(4), MAT1A(4), MAT2B(12), METTL2B(4), METTL6(5), PAPSS1(8), PAPSS2(7), PRMT2(4), PRMT3(9), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), SCLY(3), SEPHS1(12), SEPHS2(5), WBSCR22(5) 8840900 167 48 162 51 60 65 19 2 21 0 0.128 1.000 1.000 457 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPAT6(6), AGPS(8), CHPT1(1), ENPP2(25), ENPP6(11), PAFAH1B1(2), PAFAH1B2(3), PAFAH2(2), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLD1(14), PLD2(10), PPAP2A(6), PPAP2B(3), PPAP2C(1) 8426272 148 48 142 43 45 55 20 3 24 1 0.198 1.000 1.000 458 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(8), FADD(1), IKBKB(13), IKBKG(4), IL1R1(5), IRAK1(4), MAP3K1(30), MAP3K14(6), MAP3K7(9), MYD88(3), NFKB1(10), NFKBIA(3), RELA(6), RIPK1(9), TLR4(17), TNFAIP3(3), TNFRSF1A(4), TNFRSF1B(2), TRAF6(7) 8589976 144 48 143 33 31 56 26 1 27 3 0.0731 1.000 1.000 459 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(15), G6PD(6), GCLC(8), GCLM(2), GGT1(5), GPX2(1), GPX3(2), GPX5(6), GPX6(7), GPX7(1), GSR(6), GSS(5), GSTA1(2), GSTA2(6), GSTA3(5), GSTA4(3), GSTA5(4), GSTK1(6), GSTM1(2), GSTM2(3), GSTM3(5), GSTM4(1), GSTM5(2), GSTO2(1), GSTP1(2), GSTT1(1), GSTT2(1), GSTZ1(5), IDH1(4), IDH2(5), MGST1(4), MGST3(2), TXNDC12(5) 7340923 133 47 129 42 40 47 31 2 12 1 0.282 1.000 1.000 460 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(5), GALNS(4), GLB1(6), GNS(5), GUSB(5), HEXA(3), HEXB(5), HGSNAT(9), HPSE(6), HPSE2(11), HYAL1(2), HYAL2(4), IDS(8), IDUA(7), LCT(32), NAGLU(3), SPAM1(15) 7347340 130 47 130 53 29 56 26 3 16 0 0.881 1.000 1.000 461 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(5), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2), CYP2C19(6), CYP2C9(5), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), ECHS1(3), EHHADH(11), ESCO1(16), ESCO2(8), HADHA(6), NAT6(1), PNPLA3(7), SH3GLB1(7), YOD1(3) 11203507 125 47 124 43 38 52 21 2 12 0 0.564 1.000 1.000 462 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 26 ACAA1(5), ACAA2(3), ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), AKR1C4(6), AKR1D1(8), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH9A1(2), BAAT(7), CEL(5), CYP27A1(9), CYP7A1(11), HADHB(4), SOAT2(5), SRD5A1(6) 8301184 159 46 156 48 53 54 32 3 17 0 0.121 1.000 1.000 463 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(4), POLD1(12), POLD2(6), POLE(47), POLG(6), POLL(7), POLQ(29) 6044414 111 46 98 30 32 57 15 1 6 0 0.164 1.000 1.000 464 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 21 ABP1(5), ALDH1A3(8), ALDH3A1(7), ALDH3B2(7), AOC2(7), AOC3(10), DDC(9), EPX(15), GOT1(9), GOT2(3), HPD(2), LPO(6), MAOA(12), MAOB(7), MPO(10), PRDX2(4), PRDX5(1), PRDX6(4), TAT(7), TPO(15) 7660602 148 46 144 54 50 52 28 3 15 0 0.486 1.000 1.000 465 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 18 CHUK(8), DUSP1(2), IKBKAP(13), IKBKB(13), IKBKG(4), LTA(3), MAP3K1(30), MAP3K14(6), NFKB1(10), NFKBIA(3), RELA(6), RIPK1(9), TANK(5), TNFAIP3(3), TNFRSF1B(2), TRAF1(5), TRAF2(3), TRAF3(5) 8209617 130 46 129 32 32 52 20 1 23 2 0.0868 1.000 1.000 466 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(9), AGT(8), AGTR2(11), EDN1(4), EDNRA(5), EDNRB(4), EGF(19), EGFR(12), FOS(3), HRAS(1), JUN(1), MYC(8), NFKB1(10), PLCG1(12), PRKCA(10), RELA(6) 7459154 123 45 119 48 30 48 31 2 12 0 0.797 1.000 1.000 467 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(1), ALDOA(5), ALDOB(9), ALDOC(3), FBP1(2), FBP2(1), FPGT(6), GCK(3), GMDS(4), GMPPA(6), GMPPB(2), HK1(11), HK2(9), HK3(10), KHK(2), MPI(5), PFKFB1(8), PFKFB3(4), PFKFB4(4), PFKM(9), PFKP(8), PMM2(6), SORD(5), TPI1(2) 8759023 125 45 123 60 50 35 24 0 16 0 0.946 1.000 1.000 468 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 14 AGA(7), FUCA1(3), FUCA2(4), GLB1(6), HEXA(3), HEXB(5), LCT(32), MAN2B1(14), MAN2B2(5), MAN2C1(7), MANBA(12), NEU2(4), NEU3(3) 6888206 105 45 104 41 29 41 22 3 10 0 0.778 1.000 1.000 469 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(2), ASNS(9), CA1(6), CA12(1), CA13(4), CA14(4), CA2(2), CA3(5), CA4(1), CA5A(6), CA5B(7), CA6(3), CA7(5), CA8(6), CA9(4), CPS1(23), CTH(6), GLS(11), GLS2(7), GLUD1(3), GLUD2(9), GLUL(7), HAL(6) 7721466 137 45 132 47 41 50 18 2 24 2 0.564 1.000 1.000 470 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(16), POLR1B(16), POLR1C(2), POLR1D(3), POLR2A(21), POLR2B(21), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(2), POLR2H(3), POLR2J(1), POLR2K(2), POLR3A(7), POLR3B(14), POLR3G(3), POLR3GL(2), POLR3H(5) 8487029 127 45 126 36 45 45 17 2 17 1 0.201 1.000 1.000 471 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(5), ALDOB(9), ALDOC(3), FBP1(2), FBP2(1), G6PD(6), GPI(7), H6PD(7), PFKM(9), PFKP(8), PGD(3), PGLS(2), PGM1(7), PGM3(4), PRPS1(3), PRPS1L1(5), PRPS2(7), RBKS(1), RPE(5), RPIA(9), TAL1(1), TALDO1(6), TKT(6) 7121683 116 45 112 42 44 38 20 1 13 0 0.392 1.000 1.000 472 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(8), CHUK(8), IFNG(9), IKBKB(13), IL2(2), IL4(1), JUN(1), MAP3K1(30), MAP3K5(25), MAP4K5(7), MAPK14(4), MAPK8(10), NFKB1(10), NFKBIA(3), RELA(6), TNFRSF9(2), TNFSF9(6), TRAF2(3) 7209024 148 44 144 40 40 63 20 1 22 2 0.249 1.000 1.000 473 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(4), CFL1(1), GNAQ(3), GNAS(24), GNB1(2), GNGT1(1), HRAS(1), LIMK1(8), MAP2K1(2), MAPK1(2), MAPK3(3), MYL2(2), NOX1(16), PIK3C2G(16), PLCB1(5), PPP1R12B(20), PRKCA(10), PTK2(12), RAF1(8), ROCK2(17) 9254834 157 44 152 49 48 50 34 3 22 0 0.559 1.000 1.000 474 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(6), AMD1(3), BHMT(2), CBS(11), CTH(6), DNMT1(14), DNMT3A(8), DNMT3B(15), MARS(11), MARS2(4), MAT1A(4), MAT2B(12), MTAP(4), MTR(11), SRM(1), TAT(7) 7468924 119 44 116 52 47 40 20 1 11 0 0.868 1.000 1.000 475 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 66 FAU(2), MRPS7(3), RPL10A(1), RPL10L(8), RPL11(3), RPL13(1), RPL13A(1), RPL14(3), RPL18(1), RPL18A(2), RPL19(4), RPL21(3), RPL22L1(5), RPL23A(5), RPL24(2), RPL27(1), RPL27A(3), RPL28(3), RPL29(2), RPL3(2), RPL34(1), RPL35A(2), RPL36AL(1), RPL37(3), RPL37A(1), RPL38(1), RPL39(4), RPL3L(3), RPL6(3), RPL7(1), RPL8(2), RPL9(2), RPS10(1), RPS11(1), RPS12(2), RPS13(1), RPS15A(1), RPS16(1), RPS18(3), RPS20(3), RPS21(3), RPS24(2), RPS25(2), RPS27(1), RPS28(1), RPS29(2), RPS3(3), RPS3A(1), RPS6(7), RPS7(5), RPS8(2), RPS9(1), RPSA(1) 8167792 123 44 120 39 36 49 27 3 8 0 0.685 1.000 1.000 476 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(19), CALM1(2), CALM2(4), CAPN2(11), CAPNS1(2), CAPNS2(3), EP300(32), HDAC1(5), HDAC2(5), MEF2D(7), NFATC1(10), NFATC2(13), PPP3CA(4), PPP3CB(5), PPP3CC(6), PRKCA(10), SYT1(4) 8576701 142 44 137 42 52 32 33 1 24 0 0.233 1.000 1.000 477 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL4(5), CCR1(4), CCR2(5), CCR3(4), CCR4(5), CCR5(6), CCR7(6), CD28(3), CD4(6), CSF2(1), CXCR3(5), CXCR4(1), IFNG(9), IFNGR1(4), IFNGR2(4), IL12A(5), IL12B(2), IL12RB1(13), IL12RB2(10), IL18R1(9), IL2(2), IL4(1), IL4R(6), IL5(2), TGFB1(2), TGFB2(5), TGFB3(9) 7439499 134 44 133 43 38 52 24 1 19 0 0.293 1.000 1.000 478 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(21), ADRB2(7), GNAS(24), PLCE1(41), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3) 5147041 120 44 116 34 44 29 29 1 16 1 0.163 1.000 1.000 479 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(12), DYRK1B(4), GLI2(10), GLI3(28), GSK3B(13), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), SHH(4), SMO(9), SUFU(3) 5610085 110 44 107 55 39 39 12 3 15 2 0.903 1.000 1.000 480 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(7), CYB5R3(5), GCK(3), GFPT1(9), GNE(10), GNPDA1(2), GNPDA2(10), HEXA(3), HEXB(5), HK1(11), HK2(9), HK3(10), PGM3(4), RENBP(4), UAP1(6) 6187133 98 43 97 36 35 25 23 1 14 0 0.719 1.000 1.000 481 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(5), CALCR(9), CALCRL(8), CD97(13), CRHR1(3), CRHR2(2), ELTD1(12), EMR1(22), EMR2(6), GHRHR(2), GIPR(5), GLP1R(5), GLP2R(11), GPR64(11), LPHN1(16), LPHN2(22), LPHN3(21), SCTR(5), VIPR1(3), VIPR2(4) 10055000 185 43 179 70 55 79 27 1 21 2 0.524 1.000 1.000 482 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 23 ABP1(5), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH3B2(7), ALDH9A1(2), AOC2(7), AOC3(10), ASPA(5), CNDP1(4), DDC(9), HAL(6), HARS(5), HDC(9), HNMT(4), MAOA(12), MAOB(7), PRPS1(3), PRPS2(7) 8613975 150 43 144 53 45 50 32 3 20 0 0.482 1.000 1.000 483 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(17), BIRC2(10), BIRC3(5), CASP10(8), CASP3(4), CASP7(4), CASP8(21), CASP9(3), DFFB(4), GZMB(4), PRF1(8), SCAP(12), SREBF1(2), SREBF2(13) 6378058 115 43 110 37 31 44 16 0 24 0 0.471 1.000 1.000 484 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(5), EPHA4(19), EPHB1(26), FYN(7), ITGA1(17), ITGB1(8), L1CAM(20), LYN(9), RAP1B(2), SELP(12) 5796064 125 42 122 38 40 47 22 1 15 0 0.191 1.000 1.000 485 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(3), B4GALNT1(6), GLB1(6), HEXA(3), HEXB(5), LCT(32), SLC33A1(9), ST3GAL1(2), ST3GAL2(6), ST3GAL5(5), ST6GALNAC3(8), ST6GALNAC4(4), ST6GALNAC5(2), ST6GALNAC6(6), ST8SIA1(2), ST8SIA5(8) 5831166 107 42 105 40 31 42 18 2 14 0 0.631 1.000 1.000 486 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(5), ADCY1(21), CAP1(7), CCNB1(8), CDC25C(5), GNAI1(5), GNAS(24), GNB1(2), GNGT1(1), HRAS(1), MAPK1(2), MAPK3(3), MYT1(18), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), RPS6KA1(1), SRC(3) 7150582 133 42 129 40 50 41 23 1 17 1 0.136 1.000 1.000 487 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(2), ASNS(9), CA1(6), CA12(1), CA14(4), CA2(2), CA3(5), CA4(1), CA5A(6), CA5B(7), CA6(3), CA7(5), CA8(6), CA9(4), CPS1(23), CTH(6), GLS(11), GLS2(7), GLUD1(3), GLUL(7), HAL(6) 6927980 124 42 119 37 35 46 17 2 22 2 0.317 1.000 1.000 488 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(10), GALNT10(8), GALNT2(9), GALNT3(7), GALNT4(8), GALNT6(1), GALNT7(13), GALNT8(11), GALNT9(8), GCNT1(5), ST3GAL1(2), ST3GAL2(6), ST3GAL4(3), WBSCR17(15) 5377050 106 42 104 32 29 40 27 1 9 0 0.357 1.000 1.000 489 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(12), EXT2(6), EXTL1(9), EXTL2(8), EXTL3(10), GLCE(5), HS2ST1(7), HS3ST1(5), HS3ST2(5), HS3ST3A1(2), HS3ST3B1(5), HS3ST5(9), HS6ST1(2), HS6ST2(12), HS6ST3(3), NDST1(14), NDST2(9), NDST3(14), NDST4(15) 7439901 152 41 150 45 42 60 32 1 16 1 0.204 1.000 1.000 490 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(6), CSF1(6), CSF2(1), CSF3(1), HLA-DRA(1), IFNA1(2), IFNB1(3), IFNG(9), IL10(3), IL11(2), IL12A(5), IL12B(2), IL15(2), IL2(2), IL3(2), IL4(1), IL5(2), IL6(5), IL7(1), IL8(3), LTA(3), PDGFA(3), TGFB1(2), TGFB2(5), TGFB3(9) 4650214 81 41 80 28 24 37 11 1 8 0 0.463 1.000 1.000 491 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(6), BHMT(2), CBS(11), CTH(6), DNMT1(14), DNMT3A(8), DNMT3B(15), MARS(11), MARS2(4), MAT1A(4), MAT2B(12), MTR(11) 6295427 104 41 101 43 42 34 16 1 11 0 0.762 1.000 1.000 492 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(21), ARHGEF1(12), GNA12(8), GNA13(7), GNAQ(3), GNB1(2), GNGT1(1), MYL2(2), MYLK(14), PLCB1(5), PPP1R12B(20), PRKCA(10), ROCK1(22) 7598901 127 41 123 50 43 41 27 2 11 3 0.868 1.000 1.000 493 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(3), ARFGAP1(2), ARFGAP3(4), ARFGEF2(27), CLTB(6), COPA(19), GBF1(14), GPLD1(13), KDELR1(3), KDELR3(4) 5936033 95 40 93 29 36 29 21 0 8 1 0.349 1.000 1.000 494 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(5), CR1(22), CR2(24), FCGR2B(3), HLA-DRA(1), ICAM1(2), ITGAL(17), ITGB2(14), PTPRC(17) 5411848 105 40 104 30 34 38 17 2 13 1 0.137 1.000 1.000 495 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(17), ARHGDIB(3), BIRC2(10), BIRC3(5), CASP1(8), CASP10(8), CASP2(6), CASP3(4), CASP4(5), CASP6(7), CASP7(4), CASP8(21), CASP9(3), CYCS(2), DFFB(4), GZMB(4), LMNA(7), LMNB1(5), LMNB2(4), PRF1(8) 6936180 135 40 129 40 35 52 21 1 26 0 0.463 1.000 1.000 496 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(12), CSF1R(8), EGF(19), EGFR(12), GRB2(3), MET(17), PDGFRA(24), PRKCA(10), SH3GLB1(7), SH3GLB2(6), SH3KBP1(7), SRC(3) 7155198 128 40 125 44 33 45 32 0 16 2 0.477 1.000 1.000 497 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(5), C1QB(3), C1R(11), C1S(8), C2(3), C3(22), C5(18), C6(16), C7(20), C8A(9), C9(19), MASP1(15), MASP2(7), MBL2(4) 7752035 160 40 153 56 35 77 30 0 16 2 0.627 1.000 1.000 498 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(15), CD2(4), CD33(6), CD5(10), CD7(3), CSF2(1), IFNA1(2), IFNB1(3), IFNG(9), IL10(3), IL12A(5), IL12B(2), IL3(2), IL4(1), IL5(2), ITGAX(14), TLR2(16), TLR4(17), TLR7(17), TLR9(6) 6754142 138 40 136 41 41 58 20 1 16 2 0.0937 1.000 1.000 499 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 ANPEP(15), G6PD(6), GCLC(8), GCLM(2), GGT1(5), GPX2(1), GPX3(2), GPX5(6), GSS(5), GSTA1(2), GSTA2(6), GSTA3(5), GSTA4(3), GSTM1(2), GSTM2(3), GSTM3(5), GSTM4(1), GSTM5(2), GSTO2(1), GSTP1(2), GSTT1(1), GSTT2(1), GSTZ1(5), IDH1(4), IDH2(5), MGST1(4), MGST3(2), PGD(3) 6581275 107 40 104 34 29 42 26 1 8 1 0.334 1.000 1.000 500 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 21 AOX1(18), BST1(1), CD38(6), ENPP1(12), ENPP3(18), NADK(9), NADSYN1(6), NMNAT1(3), NMNAT2(3), NMNAT3(1), NNMT(6), NNT(7), NT5C(1), NT5C1A(2), NT5C1B(8), NT5C2(6), NT5C3(8), NT5E(6), NT5M(3), NUDT12(4), QPRT(2) 7699061 130 40 127 37 42 44 38 0 6 0 0.135 1.000 1.000 501 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 12 AGA(7), FUCA1(3), FUCA2(4), GLB1(6), HEXA(3), HEXB(5), LCT(32), MAN2C1(7), MANBA(12), NEU2(4), NEU3(3) 5549271 86 40 85 32 19 33 22 2 10 0 0.788 1.000 1.000 502 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(3), BLVRA(1), BLVRB(1), CP(15), CPOX(6), EPRS(15), FECH(7), GUSB(5), HCCS(1), HMBS(8), HMOX1(4), HMOX2(3), UGT1A1(6), UGT1A10(7), UGT1A3(2), UGT1A4(5), UGT1A5(7), UGT1A6(3), UGT1A7(7), UGT1A8(5), UGT1A9(3), UGT2B15(9), UGT2B4(11), UROD(3), UROS(3) 10003330 140 40 135 44 43 63 20 1 13 0 0.434 1.000 1.000 503 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(11), GTF2A1(3), GTF2B(5), GTF2E1(3), GTF2F1(7), HDAC3(12), NCOA1(19), NCOA2(15), NCOA3(10), NCOR2(23), POLR2A(21), RARA(2), RXRA(3), TBP(3) 8960600 137 40 134 46 54 41 27 1 14 0 0.444 1.000 1.000 504 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(2), CALM2(4), CCL4(5), CCR5(6), CXCL12(6), CXCR4(1), FOS(3), GNAQ(3), JUN(1), MAPK14(4), MAPK8(10), PLCG1(12), PRKCA(10), PTK2B(16), SYT1(4) 4962945 87 39 84 34 29 31 18 0 9 0 0.710 1.000 1.000 505 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(5), C1QB(3), C1R(11), C1S(8), C2(3), C3(22), C5(18), C6(16), C7(20), C8A(9), C8B(5), C9(19), MASP1(15) 7552563 154 39 146 53 34 70 31 0 17 2 0.600 1.000 1.000 506 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(4), GABARAP(1), GABRA1(14), GABRA2(13), GABRA3(14), GABRA4(19), GABRA5(10), GABRA6(7), GPHN(18), NSF(3), SRC(3), UBQLN1(6) 4390786 112 39 106 33 32 47 20 0 13 0 0.284 1.000 1.000 507 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 34 BET1(3), BET1L(1), BNIP1(4), GOSR1(3), GOSR2(1), SNAP23(3), SNAP25(9), SNAP29(4), STX10(1), STX11(6), STX12(3), STX16(1), STX17(1), STX18(2), STX19(3), STX2(7), STX3(7), STX4(6), STX5(5), STX6(3), STX7(6), STX8(3), TSNARE1(3), USE1(4), VAMP1(1), VAMP3(1), VAMP4(1), VAMP5(1), VAMP7(4), VTI1A(1), VTI1B(6), YKT6(4) 5962055 108 39 104 32 39 33 21 0 15 0 0.370 1.000 1.000 508 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG3(2), ATG5(3), ATG7(5), BECN1(1), GABARAP(1), GABARAPL1(3), IFNA1(2), IFNA10(3), IFNA13(3), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(2), IFNA21(1), IFNA4(3), IFNA5(5), IFNA6(2), IFNA7(1), IFNA8(3), IFNG(9), INS(3), PIK3C3(14), PIK3R4(21), PRKAA1(8), PRKAA2(10), ULK1(5), ULK2(12), ULK3(5) 7623927 138 39 137 40 33 65 25 0 15 0 0.446 1.000 1.000 509 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(14), ABCC2(30), ABCG2(16), BCHE(17), CES1(13), CES2(2), CYP3A4(10), CYP3A5(6), UGT1A1(6), UGT1A10(7), UGT1A3(2), UGT1A4(5), UGT1A5(7), UGT1A6(3), UGT1A7(7), UGT1A8(5), UGT1A9(3) 8435358 153 39 149 45 35 65 40 0 11 2 0.181 1.000 1.000 510 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 CALM1(2), CALM2(4), CDKN1A(1), GNAQ(3), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(5), PLCG1(12), PPP3CA(4), PPP3CB(5), PPP3CC(6), PRKCA(10), SP1(7), SP3(10), SYT1(4) 7204844 108 38 104 44 39 34 23 0 12 0 0.813 1.000 1.000 511 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(21), GNAS(24), GNB1(2), GNGT1(1), PPP2CA(6), PRKAA1(8), PRKAA2(10), PRKAB1(6), PRKAB2(1), PRKACB(3), PRKACG(9), PRKAG1(3), PRKAG2(4), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3) 5373906 113 38 109 36 46 33 16 2 15 1 0.343 1.000 1.000 512 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(19), EGFR(12), MAP2K1(2), MAP3K1(30), MAPK14(4), NCOR2(23), RARA(2), RXRA(3), THRA(6), THRB(4) 6019780 105 38 103 38 29 35 22 1 17 1 0.694 1.000 1.000 513 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(5), GALNS(4), GLB1(6), GNS(5), GUSB(5), HEXA(3), HEXB(5), IDS(8), IDUA(7), LCT(32), NAGLU(3) 5119464 83 38 83 34 20 32 18 3 10 0 0.790 1.000 1.000 514 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(33), ACACB(29), FASN(7), MCAT(3), OLAH(7), OXSM(6) 5404313 85 38 82 38 33 25 15 2 8 2 0.838 1.000 1.000 515 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(6), CD2(4), CD3D(6), CD3E(2), CD3G(3), CD4(6), CXCR3(5), IFNG(9), IL12A(5), IL12B(2), IL12RB1(13), IL12RB2(10), JAK2(17), STAT4(7), TYK2(10) 5451266 105 38 104 30 22 48 18 1 13 3 0.298 1.000 1.000 516 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(16), POLR2A(21), POLR2B(21), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(2), POLR2H(3), POLR2J(1), POLR2K(2), POLRMT(11) 4571137 86 38 85 25 33 28 13 0 11 1 0.289 1.000 1.000 517 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(8), F2R(6), GNAI1(5), GNB1(2), GNGT1(1), HRAS(1), ITGA1(17), ITGB1(8), MAP2K1(2), MAPK1(2), MAPK3(3), PLA2G4A(13), PLCB1(5), PRKCA(10), PTGS1(6), PTK2(12), RAF1(8), SRC(3), SYK(4), TBXAS1(7) 8821295 123 38 122 48 30 44 29 4 16 0 0.830 1.000 1.000 518 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(2), CDK5R1(3), CSNK1D(3), DRD1(6), DRD2(8), GRM1(29), PLCB1(5), PPP1CA(3), PPP1R1B(2), PPP2CA(6), PPP3CA(4), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3) 5735718 98 37 97 44 31 37 12 4 13 1 0.810 1.000 1.000 519 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(9), CARS2(5), CDO1(4), CTH(6), GOT1(9), GOT2(3), LDHA(8), LDHAL6A(8), LDHAL6B(2), LDHB(3), LDHC(4), MPST(1), SDS(1), SULT1B1(7), SULT1C2(4), SULT1C4(4), SULT4A1(4) 4529700 82 37 79 33 19 32 19 2 10 0 0.890 1.000 1.000 520 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(6), ABP1(5), AOC2(7), AOC3(10), CES1(13), DDHD1(8), ESCO1(16), ESCO2(8), LIPA(8), NAT6(1), PLA1A(6), PNPLA3(7), PPME1(3), PRDX6(4), SH3GLB1(7) 9195734 109 37 106 40 27 45 24 0 12 1 0.765 1.000 1.000 521 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(4), IL22RA1(4), IL22RA2(1), JAK1(20), JAK2(17), JAK3(10), STAT1(15), STAT3(10), STAT5A(5), STAT5B(7), TYK2(10) 6607070 103 37 102 42 29 39 18 0 14 3 0.807 1.000 1.000 522 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ATP6V0C(1), CAT(4), EPX(15), LPO(6), MPO(10), PRDX2(4), PRDX5(1), PRDX6(4), SHMT1(5), SHMT2(5), TPO(15) 4251973 70 37 68 28 29 26 8 1 6 0 0.680 1.000 1.000 523 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 10 CD44(5), ICAM1(2), ITGA4(10), ITGAL(17), ITGAM(21), ITGB1(8), ITGB2(14), SELE(5), SELL(5), SELP(12) 5968706 99 37 95 36 28 41 14 1 14 1 0.576 1.000 1.000 524 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(2), CALM2(4), CAMK1(2), CAMK1G(5), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CAMK4(5), ESRRA(2), HDAC5(12), MEF2A(3), MEF2B(1), MEF2C(11), MEF2D(7), PPARA(1), PPP3CA(4), PPP3CB(5), PPP3CC(6), SLC2A4(9), SYT1(4), YWHAH(3) 7515013 108 37 107 38 42 31 20 0 15 0 0.435 1.000 1.000 525 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(3), ALDH18A1(9), ARG1(5), ARG2(3), ASL(2), CKM(3), CKMT1A(1), CKMT2(4), CPS1(23), GAMT(3), GATM(5), GLUD1(3), NAGS(3), OAT(7), ODC1(2), OTC(7), PYCR1(3), SMS(8) 6217565 94 37 93 37 30 33 17 2 10 2 0.838 1.000 1.000 526 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(5), C1QB(3), C1R(11), C1S(8), C2(3), C3(22), C5(18), C6(16), C7(20), C8A(9), C9(19) 6333689 134 36 128 46 25 62 29 0 16 2 0.663 1.000 1.000 527 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(5), ACP2(1), ACP5(5), ACP6(4), ACPP(5), ACPT(5), ALPI(4), ALPL(5), ALPP(3), ALPPL2(3), CMBL(3), CYP3A4(10), CYP3A43(4), CYP3A5(6), CYP3A7(7), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), PON1(12), PON2(6), PON3(5) 6438004 109 36 107 32 25 42 27 1 14 0 0.205 1.000 1.000 528 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 CAT(4), EPX(15), LPO(6), MPO(10), MTHFR(10), PRDX6(4), SHMT1(5), SHMT2(5), TPO(15) 4173957 74 36 71 27 32 24 8 2 8 0 0.542 1.000 1.000 529 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(11), ESR2(5), ITPKA(1), PDE1A(15), PDE1B(7), PLCB1(5), PLCB2(8), PRL(6), TRH(1), VIP(3) 3949492 62 36 61 29 17 19 16 3 7 0 0.970 1.000 1.000 530 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(5), ACTR2(6), ACTR3(1), ARPC1A(6), ARPC1B(5), ARPC2(1), ARPC3(1), ARPC4(1), NCK1(4), NCKAP1(8), NTRK1(13), PIR(6), PSMA7(2), RAC1(1), WASF1(3), WASF2(3), WASF3(8), WASL(8) 5632560 82 35 82 29 26 39 10 0 7 0 0.610 1.000 1.000 531 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 15 GATA3(3), IL4(1), IL5(2), MAF(2), MAP2K3(7), MAPK14(4), NFATC1(10), NFATC2(13), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3) 3863826 69 35 67 30 26 20 13 1 8 1 0.602 1.000 1.000 532 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(17), ACO2(7), CS(6), GRHPR(3), HAO1(3), HAO2(10), HYI(2), MDH1(4), MDH2(4), MTHFD1(6), MTHFD1L(15), MTHFD2(4) 4710422 81 35 79 26 36 22 18 0 5 0 0.279 1.000 1.000 533 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(32), ABCB11(15), ABCB4(28), ABCC1(14), ABCC3(13), GSTP1(2) 5405704 104 35 101 38 21 39 25 0 16 3 0.644 1.000 1.000 534 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), ALG5(2), B4GALT1(2), B4GALT2(5), B4GALT3(10), B4GALT5(2), DDOST(3), DPAGT1(3), DPM1(2), FUT8(13), MAN1A1(13), MAN1B1(5), MGAT1(4), MGAT2(4), MGAT3(4), MGAT4A(5), MGAT4B(6), MGAT5(11), RPN1(3), RPN2(5), ST6GAL1(7) 6843201 110 35 102 33 39 35 27 1 8 0 0.322 1.000 1.000 535 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(8), ADSS(6), DHFR(5), HPRT1(2), IMPDH1(6), MTHFD2(4), OAZ1(1), POLB(4), POLD1(12), POLG(6), PRPS2(7), RRM1(2), SRM(1) 4466818 64 35 62 26 23 21 13 1 6 0 0.821 1.000 1.000 536 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(10), AMT(2), ATIC(7), ATP6V0C(1), DHFR(5), GART(9), MTHFD1(6), MTHFD1L(15), MTHFD2(4), MTHFR(10), MTR(11), SHMT1(5), SHMT2(5) 6599249 90 35 87 32 37 31 14 1 7 0 0.379 1.000 1.000 537 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(15), GBA3(9), LPO(6), MPO(10), PRDX2(4), PRDX5(1), PRDX6(4), TPO(15), TYR(12) 3491995 76 35 74 27 25 29 14 1 7 0 0.567 1.000 1.000 538 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(11), CYP2A13(8), CYP2A6(11), CYP2A7(5), NAT1(7), NAT2(4), XDH(14) 2966743 60 34 56 22 19 30 8 0 3 0 0.505 1.000 1.000 539 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT1(4), B3GAT2(1), B3GAT3(2), B4GALT7(4), CHPF(5), CHST11(8), CHST12(3), CHST14(3), CHST3(4), CHST7(4), CHSY1(8), DSE(19), UST(3), XYLT1(16), XYLT2(4) 4484184 88 34 87 34 35 28 21 0 4 0 0.620 1.000 1.000 540 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(10), AMT(2), ATIC(7), DHFR(5), FTCD(8), GART(9), MTHFD1(6), MTHFD1L(15), MTHFD2(4), MTHFR(10), MTR(11), SHMT1(5), SHMT2(5) 6928161 97 34 94 34 38 34 17 1 7 0 0.390 1.000 1.000 541 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(33), CPT1A(9), LEP(2), LEPR(12), PRKAA1(8), PRKAA2(10), PRKAB1(6), PRKAB2(1), PRKAG1(3), PRKAG2(4) 5343713 88 34 85 26 26 33 14 2 13 0 0.456 1.000 1.000 542 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(15), CKM(3), EIF4E(2), FBL(3), GPT(2), LDHA(8), LDHB(3), LDHC(4), MAPK14(4), NCL(7) 3281547 51 34 51 24 9 20 11 3 7 1 0.958 1.000 1.000 543 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(3), CD3D(6), CD3E(2), CD3G(3), IFNG(9), IL2(2), IL2RA(4), IL4(1), TGFB1(2), TGFB2(5), TGFB3(9), TGFBR1(5), TGFBR2(6), TGFBR3(15), TOB1(4), TOB2(5) 3917492 81 34 81 31 25 35 11 1 9 0 0.761 1.000 1.000 544 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(2), ACHE(4), CHAT(5), COMT(3), DBH(9), DDC(9), GAD1(6), GAD2(12), HDC(9), MAOA(12), PAH(2), PNMT(2), SLC18A3(6), TH(3), TPH1(9) 4928980 93 33 91 32 28 28 20 1 14 2 0.358 1.000 1.000 545 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(5), B3GNT2(1), B3GNT7(3), B4GALT1(2), B4GALT2(5), B4GALT3(10), B4GALT4(5), CHST1(8), CHST2(2), CHST4(4), CHST6(6), FUT8(13), ST3GAL1(2), ST3GAL2(6), ST3GAL3(10), ST3GAL4(3) 4140897 85 33 81 39 38 26 14 1 6 0 0.857 1.000 1.000 546 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(11), ACO1(17), ACO2(7), ACSS1(5), ACSS2(6), FH(8), IDH1(4), IDH2(5), MDH1(4), MDH2(4), SUCLA2(5) 4873171 76 33 75 32 30 24 15 0 7 0 0.733 1.000 1.000 547 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(15), GBA(4), GBA3(9), LPO(6), MPO(10), PRDX6(4), TPO(15) 3039937 63 33 61 24 22 25 9 1 6 0 0.640 1.000 1.000 548 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(6), CBS(11), CTH(6), GGT1(5), MARS(11), MARS2(4), MAT1A(4), MAT2B(12), PAPSS1(8), PAPSS2(7), SCLY(3), SEPHS1(12) 4419353 89 33 86 32 40 29 11 1 8 0 0.435 1.000 1.000 549 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(6), GRB2(3), HBXIP(1), HRAS(1), PTK2B(16), SHC1(7), SOS1(13), SRC(3) 3131844 50 32 47 16 16 22 10 0 2 0 0.525 1.000 1.000 550 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(4), PSMA2(4), PSMA3(5), PSMA4(2), PSMA5(2), PSMA6(1), PSMA7(2), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(1), PSMB5(4), PSMB6(4), PSMB7(2), PSMC2(3), PSMC3(1), PSMD1(12), PSMD11(6), PSMD12(5), PSMD13(1), PSMD2(10), PSMD6(3) 5921391 78 32 74 26 21 24 13 0 20 0 0.663 1.000 1.000 551 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(1), BLVRB(1), HMOX1(4), IL10(3), IL10RA(4), IL10RB(6), IL6(5), JAK1(20), STAT1(15), STAT3(10), STAT5A(5) 4358319 74 32 73 29 25 21 13 0 15 0 0.690 1.000 1.000 552 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH9A1(2), ECHS1(3), EHHADH(11), HADHA(6), SDS(1) 4375145 71 32 70 30 20 27 16 2 6 0 0.744 1.000 1.000 553 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 7 CD44(5), ICAM1(2), ITGAL(17), ITGAM(21), ITGB2(14), SELE(5), SELL(5) 3941677 69 32 68 32 21 27 9 1 10 1 0.866 1.000 1.000 554 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(4), GNAS(24), GNB1(2), GNGT1(1), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(10) 3374899 68 31 65 25 29 18 10 1 9 1 0.646 1.000 1.000 555 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(29), GNA12(8), PRKACB(3), PRKACG(9), PRKAG1(3), PRKAR2A(4), PRKAR2B(3) 3655022 59 31 57 21 15 21 14 0 8 1 0.726 1.000 1.000 556 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(20), JAK2(17), JAK3(10), MAPK1(2), MAPK3(3), STAT3(10), TYK2(10) 4165944 72 31 72 27 16 25 15 0 13 3 0.734 1.000 1.000 557 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(6), GNAQ(3), GNB1(2), GNGT1(1), HTR2C(17), PLCB1(5), TUB(13) 2575796 47 31 45 19 16 12 10 4 5 0 0.760 1.000 1.000 558 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(4), DHCR7(2), FDFT1(1), FDPS(8), HMGCR(12), HMGCS1(6), IDI1(3), LSS(6), MVD(3), MVK(3), NSDHL(10), PMVK(3), SC5DL(3), SQLE(5) 4725661 69 30 68 30 18 26 18 0 7 0 0.891 1.000 1.000 559 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(11), KHK(2), LCT(32), MPI(5), PGM1(7), PYGL(8), PYGM(10), TPI1(2), TREH(2) 4908197 79 30 79 38 20 32 19 0 8 0 0.941 1.000 1.000 560 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(8), CYP51A1(4), DHCR24(6), DHCR7(2), EBP(2), FDFT1(1), FDPS(8), GGCX(10), GGPS1(2), HMGCR(12), HSD17B7(5), IDI1(3), IDI2(1), LSS(6), MVD(3), MVK(3), NQO1(3), NSDHL(10), PMVK(3), SC5DL(3), SQLE(5), TM7SF2(2), VKORC1(1) 6930322 103 30 102 49 29 46 19 0 9 0 0.978 1.000 1.000 561 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(3), HK1(11), HK2(9), HK3(10), IMPA1(4), IMPA2(6), ISYNA1(2), PGM1(7), PGM3(4), TGDS(4) 4130241 60 30 60 31 23 17 14 0 6 0 0.927 1.000 1.000 562 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(5), ACOX1(7), ACOX3(8), ELOVL2(8), ELOVL5(2), ELOVL6(4), FADS1(4), FADS2(2), FASN(7), HADHA(6), HSD17B12(4), PECR(6), SCD(6) 4854200 69 30 69 30 26 24 12 0 7 0 0.711 1.000 1.000 563 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 8 CD44(5), ICAM1(2), ITGA4(10), ITGAL(17), ITGB1(8), ITGB2(14), SELE(5), SELL(5) 4471919 66 30 64 29 21 24 12 1 8 0 0.833 1.000 1.000 564 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(4), PSMA2(4), PSMA3(5), PSMA4(2), PSMA5(2), PSMA6(1), PSMA7(2), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(1), PSMB5(4), PSMB6(4), PSMB7(2), PSMC3(1), PSMD14(2), RPN1(3), RPN2(5), UBE2A(3), UBE3A(16) 4871346 67 30 65 24 21 15 15 1 15 0 0.732 1.000 1.000 565 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(17), ACO2(7), FH(8), IDH1(4), IDH2(5), MDH1(4), MDH2(4), SDHB(2), SUCLA2(5) 3292258 56 30 55 24 25 15 11 0 5 0 0.751 1.000 1.000 566 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(6), AKR1D1(8), CYP11A1(9), CYP11B1(8), CYP11B2(8), CYP17A1(3), CYP21A2(6), HSD11B1(6), HSD3B1(3), HSD3B2(6) 3205297 63 29 63 25 17 25 10 1 10 0 0.703 1.000 1.000 567 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(11), ERBB4(27), NRG2(4), NRG3(17), PRKCA(10), PSEN1(5) 3322589 74 29 73 28 24 24 17 0 8 1 0.767 1.000 1.000 568 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(8), CYSLTR2(5), GPR161(6), GPR171(5), GPR18(3), GPR34(9), GPR39(9), GPR45(3), GPR65(11), GPR68(6), GPR75(8) 3643783 73 29 68 32 28 21 20 0 4 0 0.740 1.000 1.000 569 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(6), AKR1D1(8), CYP11A1(9), CYP11B1(8), CYP11B2(8), CYP17A1(3), CYP21A2(6), HSD11B1(6), HSD3B1(3), HSD3B2(6) 3205297 63 29 63 25 17 25 10 1 10 0 0.703 1.000 1.000 570 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(5), FOS(3), HRAS(1), JUN(1), MAP2K1(2), MAPK1(2), MAPK3(3), MYC(8), NFKB1(10), NFKBIA(3), PLCB1(5), PRKCA(10), RAF1(8), RELA(6) 5458669 67 28 66 29 19 21 20 2 5 0 0.863 1.000 1.000 571 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(8), CYP11A1(9), CYP11B2(8), CYP17A1(3), HSD11B1(6), HSD3B1(3), HSD3B2(6) 2498956 43 28 43 19 11 16 8 0 8 0 0.732 1.000 1.000 572 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(11), CS(6), MDH1(4), ME1(12), PC(12), PDHA1(7), SLC25A1(2), SLC25A11(3) 3287841 57 28 56 25 17 26 8 1 5 0 0.812 1.000 1.000 573 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(2), CDK5R1(3), DAB1(6), FYN(7), LRP8(4), RELN(48), VLDLR(4) 5115071 74 28 71 32 11 34 20 1 7 1 0.930 1.000 1.000 574 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(9), CTH(6), GOT1(9), GOT2(3), LDHA(8), LDHB(3), LDHC(4), MPST(1) 2443982 43 27 42 16 8 19 10 1 5 0 0.813 1.000 1.000 575 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(2), B3GALNT1(6), B3GALT5(4), FUT1(4), FUT2(1), FUT9(9), GBGT1(7), GLA(9), HEXA(3), HEXB(5), NAGA(3), ST3GAL1(2), ST3GAL2(6), ST8SIA1(2) 3755630 63 27 59 25 20 27 10 1 5 0 0.657 1.000 1.000 576 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(7), CS(6), FH(8), IDH2(5), MDH1(4), OGDH(13), SDHA(15), SUCLA2(5) 3504439 63 27 62 24 28 19 13 0 3 0 0.491 1.000 1.000 577 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(6), LDLR(6), MBTPS1(9), MBTPS2(10), SCAP(12), SREBF1(2), SREBF2(13) 4072172 58 27 57 26 23 20 9 0 6 0 0.768 1.000 1.000 578 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(14), CD44(5), CSF1(6), FCGR3A(1), IL1B(2), IL6R(7), SELL(5), SPN(1), TGFB1(2), TGFB2(5), TNFRSF1A(4), TNFRSF1B(2), TNFRSF8(8), TNFSF8(1) 4738496 63 27 60 29 20 21 13 0 9 0 0.874 1.000 1.000 579 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(3), HK1(11), HK2(9), HK3(10), IMPA1(4), PGM1(7), PGM3(4), TGDS(4) 3696126 52 27 52 26 18 16 13 0 5 0 0.917 1.000 1.000 580 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(2), FDFT1(1), FDPS(8), HMGCR(12), IDI1(3), LSS(6), MVD(3), MVK(3), NQO1(3), NQO2(5), PMVK(3), SC5DL(3), SQLE(5), VKORC1(1) 3924470 58 26 56 27 16 24 13 0 5 0 0.908 1.000 1.000 581 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP3(4), CASP7(4), DFFB(4), ENDOG(1), GZMB(4), HMGB1(4), HMGB2(4), TOP2A(14), TOP2B(24) 3857901 63 26 62 20 9 22 16 0 16 0 0.850 1.000 1.000 582 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(2), FUT1(4), FUT2(1), FUT9(9), GBGT1(7), GLA(9), HEXA(3), HEXB(5), NAGA(3), ST3GAL1(2), ST3GAL2(6), ST3GAL4(3), ST8SIA1(2) 3538266 56 26 55 23 18 24 11 1 2 0 0.714 1.000 1.000 583 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(3), PLCG1(12), PRKCA(10), PTK2B(16) 2445611 41 26 40 25 20 11 9 0 1 0 0.986 1.000 1.000 584 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(5), B4GALT1(2), B4GALT2(5), B4GALT3(10), B4GALT5(2), FUT8(13), ST3GAL1(2), ST3GAL2(6), ST3GAL3(10), ST3GAL4(3) 2788833 58 26 54 18 25 17 11 1 4 0 0.416 1.000 1.000 585 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(8), CDC25A(8), CDC25B(3), CDC25C(5), CSK(1), GRB2(3), PRKCA(10), PTPRA(10), SRC(3) 3330501 51 26 50 26 19 10 14 0 8 0 0.962 1.000 1.000 586 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(6), AASDH(10), AASDHPPT(9), AASS(12), KARS(5) 2587026 42 25 39 19 6 19 12 1 4 0 0.954 1.000 1.000 587 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(3), NFKB1(10), NFKBIA(3), PLCB1(5), PRKCA(10), RELA(6) 2991782 37 25 37 22 10 11 9 2 5 0 0.987 1.000 1.000 588 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(1), MMP14(6), MMP2(7), MMP9(12), RECK(13), TIMP1(4), TIMP2(2), TIMP3(7), TIMP4(1) 2748434 53 25 53 20 13 24 10 0 6 0 0.591 1.000 1.000 589 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), B4GALT7(4), HS3ST1(5), HS3ST2(5), HS3ST3A1(2), HS3ST3B1(5), XYLT1(16), XYLT2(4) 2130232 43 24 43 16 21 11 8 0 3 0 0.495 1.000 1.000 590 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), B4GALT7(4), HS3ST1(5), HS3ST2(5), HS3ST3A1(2), HS3ST3B1(5), XYLT1(16), XYLT2(4) 2130232 43 24 43 16 21 11 8 0 3 0 0.495 1.000 1.000 591 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(6), ACAT2(4), ACYP1(2), ECHS1(3), EHHADH(11), GCDH(6), HADHA(6), SDHB(2), SDS(1) 2849217 41 23 41 15 7 19 12 0 3 0 0.703 1.000 1.000 592 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(5), ACAA2(3), ACAT1(6), ACAT2(4), ECHS1(3), EHHADH(11), HADHA(6), HADHB(4), SDS(1) 3075552 43 23 43 16 11 15 14 0 3 0 0.665 1.000 1.000 593 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(3), ALAS1(8), ALAS2(11), CPOX(6), FECH(7), HMBS(8), UROD(3), UROS(3) 2842724 49 23 47 13 20 17 7 0 5 0 0.372 1.000 1.000 594 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2), MIOX(6), UGDH(2) 3009817 39 23 38 16 18 13 4 2 2 0 0.581 1.000 1.000 595 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(4), EPHX2(7), HSD3B7(5), RDH11(1), RDH12(5), RDH13(4), RDH14(2) 1698250 28 23 28 12 12 9 4 1 2 0 0.695 1.000 1.000 596 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(7), CAMP(1), DAG1(6), GNAQ(3), ITPKA(1), ITPKB(11) 2031746 29 23 29 11 10 14 1 0 4 0 0.532 1.000 1.000 597 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(4), CHAT(5), CHKA(9), PCYT1A(4), PDHA1(7), PDHA2(9), PEMT(1), SLC18A3(6) 2387107 45 22 44 25 9 20 9 1 5 1 0.947 1.000 1.000 598 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(11), DLL1(7), FURIN(6), NOTCH1(11), PSEN1(5) 2760552 40 22 40 24 16 15 5 0 4 0 0.917 1.000 1.000 599 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(5), AOC2(7), AOC3(10), CES1(13), ESD(2) 2112292 37 21 34 15 9 12 12 0 4 0 0.728 1.000 1.000 600 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(6), AASDHPPT(9), AASS(12), KARS(5) 1761211 32 21 29 13 6 17 7 1 1 0 0.890 1.000 1.000 601 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 11 BPNT1(3), CHST11(8), CHST12(3), PAPSS1(8), PAPSS2(7), SULT1A1(3), SULT1A2(1), SULT1E1(9), SULT2A1(7), SULT2B1(4), SUOX(2) 3159305 55 21 51 18 27 20 5 0 3 0 0.442 1.000 1.000 602 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(3), ADORA2A(6), ADORA2B(1), ADORA3(5), LTB4R(2), P2RY1(3), P2RY2(3), P2RY6(4) 2030439 27 21 27 14 11 7 9 0 0 0 0.830 1.000 1.000 603 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 6 FUT1(4), FUT2(1), FUT3(8), FUT5(1), FUT6(10), ST3GAL3(10) 1510570 34 20 34 12 18 11 2 0 3 0 0.326 1.000 1.000 604 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(2), CDK5R1(3), DPM2(2), EGR1(6), HRAS(1), KLK2(2), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), NGFR(3), RAF1(8) 2829678 39 20 38 20 19 12 7 0 1 0 0.820 1.000 1.000 605 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(2), MTMR1(16), MTMR2(5), MTMR6(10), NFS1(5), PHPT1(1), TPK1(3) 2334275 42 20 41 13 10 17 6 0 9 0 0.677 1.000 1.000 606 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(6), PLCD1(5), PRKCA(10), TGM2(10) 1783266 31 20 31 17 15 7 7 0 2 0 0.889 1.000 1.000 607 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(11), CYP2E1(2), NR1I3(6), PTGS1(6), PTGS2(9) 1942207 34 19 33 11 12 11 7 1 3 0 0.540 1.000 1.000 608 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(11), GLS2(7), GLUD1(3), GLUD2(9) 1620963 30 19 29 14 9 7 6 0 8 0 0.936 1.000 1.000 609 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(8), CYCS(2), GPD2(3), NDUFA1(1), SDHA(15), SDHB(2), SDHC(4), SDHD(3), UQCRC1(2) 2400407 40 18 40 13 18 13 7 0 2 0 0.529 1.000 1.000 610 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(4), ALPL(5), ALPP(3), ALPPL2(3), DHFR(5), FPGS(5), GCH1(1), GGH(2), SPR(1) 2130667 29 18 29 13 11 11 5 0 2 0 0.630 1.000 1.000 611 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GBA(4), GBA3(9), GGT1(5), SHMT1(5), SHMT2(5) 2046382 28 18 28 12 9 12 3 0 4 0 0.693 1.000 1.000 612 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), ECHS1(3), EHHADH(11), HADHA(6), SDS(1) 1772376 22 17 22 16 3 10 8 0 1 0 0.994 1.000 1.000 613 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(3), PAPSS1(8), PAPSS2(7), SULT1A2(1), SULT1E1(9), SULT2A1(7), SUOX(2) 2256029 37 17 34 11 18 13 3 0 3 0 0.622 1.000 1.000 614 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(10), ALDH1A2(11), BCMO1(3), RDH5(3) 1414742 27 16 27 13 7 11 4 0 5 0 0.869 1.000 1.000 615 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(18), PDXK(4), PNPO(1), PSAT1(5) 1718955 28 15 28 13 7 13 5 0 3 0 0.858 1.000 1.000 616 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(3), CD4(6), CD80(5), HLA-DRA(1), IL10(3), IL2(2), IL4(1) 1330988 21 14 21 11 6 7 3 1 4 0 0.921 1.000 1.000