Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.056 0.177 -9999.0 0.0 -0.594 37.0 37.0 IHH -0.129 0.2 -9999.0 0.0 -0.394 184.0 184.0 SHH Np/Cholesterol/GAS1 -0.148 0.13 -9999.0 0.0 -0.232 349.0 349.0 LRPAP1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.147 0.129 0.231 349.0 -9999.0 0.0 349.0 SMO/beta Arrestin2 -0.052 0.155 -9999.0 0.0 -0.298 132.0 132.0 SMO -0.061 0.163 -9999.0 0.0 -0.318 133.0 133.0 AKT1 -0.018 0.096 -9999.0 0.0 -0.438 7.0 7.0 ARRB2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.003 0.077 -9999.0 0.0 -0.41 18.0 18.0 ADRBK1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.06 0.161 -9999.0 0.0 -0.315 133.0 133.0 STIL -0.049 0.115 -9999.0 0.0 -0.341 33.0 33.0 DHH N/PTCH2 -0.023 0.105 -9999.0 0.0 -0.296 66.0 66.0 DHH N/PTCH1 -0.06 0.138 -9999.0 0.0 -0.353 52.0 52.0 PIK3CA 0.01 0.018 -9999.0 0.0 -0.41 1.0 1.0 DHH -0.023 0.113 -9999.0 0.0 -0.41 41.0 41.0 PTHLH -0.07 0.213 -9999.0 0.0 -0.649 37.0 37.0 determination of left/right symmetry -0.06 0.161 -9999.0 0.0 -0.315 133.0 133.0 PIK3R1 0.007 0.041 -9999.0 0.0 -0.41 5.0 5.0 skeletal system development -0.07 0.211 -9999.0 0.0 -0.643 37.0 37.0 IHH N/Hhip -0.08 0.132 -9999.0 0.0 -0.264 154.0 154.0 DHH N/Hhip -0.024 0.098 -9999.0 0.0 -0.263 74.0 74.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.06 0.161 -9999.0 0.0 -0.315 133.0 133.0 pancreas development -0.013 0.088 -9999.0 0.0 -0.343 35.0 35.0 HHAT 0.008 0.037 -9999.0 0.0 -0.41 4.0 4.0 PI3K 0.013 0.031 -9999.0 0.0 -0.28 6.0 6.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.259 0.202 -9999.0 0.0 -0.41 338.0 338.0 somite specification -0.06 0.161 -9999.0 0.0 -0.315 133.0 133.0 SHH Np/Cholesterol/PTCH1 -0.052 0.116 -9999.0 0.0 -0.342 30.0 30.0 SHH Np/Cholesterol/PTCH2 -0.017 0.08 -9999.0 0.0 -0.18 96.0 96.0 SHH Np/Cholesterol/Megalin -0.068 0.103 -9999.0 0.0 -0.176 232.0 232.0 SHH -0.015 0.082 -9999.0 0.0 -0.223 71.0 71.0 catabolic process -0.055 0.137 -9999.0 0.0 -0.26 148.0 148.0 SMO/Vitamin D3 -0.049 0.14 -9999.0 0.0 -0.395 28.0 28.0 SHH Np/Cholesterol/Hhip -0.018 0.075 -9999.0 0.0 -0.168 102.0 102.0 LRP2 -0.111 0.163 -9999.0 0.0 -0.33 188.0 188.0 receptor-mediated endocytosis -0.076 0.137 -9999.0 0.0 -0.325 78.0 78.0 SHH Np/Cholesterol/BOC -0.012 0.074 -9999.0 0.0 -0.174 86.0 86.0 SHH Np/Cholesterol/CDO -0.03 0.097 -9999.0 0.0 -0.201 117.0 117.0 mesenchymal cell differentiation 0.018 0.075 0.167 102.0 -9999.0 0.0 102.0 mol:Vitamin D3 -0.042 0.123 -9999.0 0.0 -0.344 30.0 30.0 IHH N/PTCH2 -0.079 0.139 -9999.0 0.0 -0.278 143.0 143.0 CDON -0.036 0.133 -9999.0 0.0 -0.41 59.0 59.0 IHH N/PTCH1 -0.035 0.15 -9999.0 0.0 -0.262 148.0 148.0 Megalin/LRPAP1 -0.068 0.112 -9999.0 0.0 -0.218 188.0 188.0 PTCH2 -0.012 0.096 -9999.0 0.0 -0.41 29.0 29.0 SHH Np/Cholesterol -0.012 0.061 -9999.0 0.0 -0.165 71.0 71.0 PTCH1 -0.055 0.138 -9999.0 0.0 -0.261 148.0 148.0 HHIP -0.013 0.089 -9999.0 0.0 -0.344 35.0 35.0