E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.016 0.091 -9999.0 0.0 -0.271 57.0 57.0 KLHL20 -0.005 0.062 0.2 2.0 -0.201 28.0 30.0 CYFIP2 0.02 0.028 -9999.0 0.0 -0.349 3.0 3.0 Rac1/GDP 0.001 0.068 0.247 3.0 -0.259 7.0 10.0 ENAH -0.019 0.093 -9999.0 0.0 -0.275 58.0 58.0 AP1M1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.023 0.001 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.014 0.027 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.013 0.037 -9999.0 0.0 -0.137 29.0 29.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.048 0.028 0.208 1.0 -0.19 2.0 3.0 RAPGEF1 -0.012 0.079 0.224 2.0 -0.308 9.0 11.0 CTNND1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.012 0.1 -9999.0 0.0 -0.28 63.0 63.0 CRK -0.009 0.082 -9999.0 0.0 -0.267 42.0 42.0 E-cadherin/gamma catenin/alpha catenin 0.039 0.027 -9999.0 0.0 -0.296 2.0 2.0 alphaE/beta7 Integrin 0.032 0.013 0.208 1.0 -9999.0 0.0 1.0 IQGAP1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.042 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.013 0.087 -9999.0 0.0 -0.274 50.0 50.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.016 0.016 -9999.0 0.0 -0.127 2.0 2.0 MLLT4 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.036 0.036 -9999.0 0.0 -0.185 12.0 12.0 PI3K -0.02 0.02 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.028 0.027 -9999.0 0.0 -0.345 2.0 2.0 TIAM1 0.013 0.058 -9999.0 0.0 -0.349 13.0 13.0 E-cadherin(dimer)/Ca2+ 0.046 0.025 -9999.0 0.0 -0.178 2.0 2.0 AKT1 -0.012 0.02 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.018 0.037 -9999.0 0.0 -0.349 5.0 5.0 CDH1 0.019 0.024 -9999.0 0.0 -0.349 2.0 2.0 RhoA/GDP 0.0 0.067 0.231 1.0 -0.262 5.0 6.0 actin cytoskeleton organization -0.003 0.048 0.173 3.0 -0.147 28.0 31.0 CDC42/GDP 0.002 0.068 0.247 3.0 -0.267 6.0 9.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.012 0.02 -9999.0 0.0 -0.284 2.0 2.0 ITGB7 0.023 0.012 0.279 1.0 -9999.0 0.0 1.0 RAC1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.049 0.026 -9999.0 0.0 -0.19 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.034 0.02 -9999.0 0.0 -0.174 2.0 2.0 mol:GDP -0.011 0.073 0.254 3.0 -0.286 9.0 12.0 CDC42/GTP/IQGAP1 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.021 0.017 -9999.0 0.0 -0.349 1.0 1.0 p120 catenin/RhoA/GDP 0.008 0.069 0.235 1.0 -0.273 4.0 5.0 RAC1/GTP/IQGAP1 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.004 0.036 0.164 5.0 -0.102 12.0 17.0 NME1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.01 0.084 -9999.0 0.0 -0.27 48.0 48.0 regulation of cell-cell adhesion 0.008 0.023 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.001 0.025 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.017 0.037 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.056 0.034 -9999.0 0.0 -0.26 2.0 2.0 CCND1 0.004 0.043 0.186 5.0 -0.123 12.0 17.0 VAV2 -0.03 0.163 -9999.0 0.0 -0.562 34.0 34.0 RAP1/GDP 0.017 0.06 0.251 4.0 -0.258 3.0 7.0 adherens junction assembly -0.011 0.084 -9999.0 0.0 -0.264 50.0 50.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.04 0.029 -9999.0 0.0 -0.253 2.0 2.0 E-cadherin/beta catenin 0.008 0.019 -9999.0 0.0 -0.29 2.0 2.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.016 0.092 -9999.0 0.0 -0.274 57.0 57.0 PIK3CA 0.02 0.018 -9999.0 0.0 -0.349 1.0 1.0 Rac1/GTP -0.018 0.085 -9999.0 0.0 -0.312 29.0 29.0 E-cadherin/beta catenin/alpha catenin 0.039 0.023 -9999.0 0.0 -0.208 2.0 2.0 ITGAE 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.013 0.102 -9999.0 0.0 -0.284 63.0 63.0