Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.003 0.09 0.255 50.0 -0.215 11.0 61.0 KIRREL -0.017 0.113 -9999.0 0.0 -0.355 52.0 52.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.003 0.09 0.215 11.0 -0.255 50.0 61.0 PLCG1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.023 0.078 0.222 11.0 -0.19 49.0 60.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.005 0.07 0.196 3.0 -0.207 48.0 51.0 FYN 0.017 0.116 0.228 97.0 -0.183 49.0 146.0 mol:Ca2+ 0.02 0.075 0.338 1.0 -0.189 48.0 49.0 mol:DAG 0.021 0.076 0.343 1.0 -0.19 48.0 49.0 NPHS2 -0.008 0.033 0.298 3.0 -9999.0 0.0 3.0 mol:IP3 0.021 0.076 0.343 1.0 -0.19 48.0 49.0 regulation of endocytosis 0.015 0.068 0.19 9.0 -0.173 49.0 58.0 Nephrin/NEPH1/podocin/Cholesterol 0.013 0.073 0.205 12.0 -0.186 50.0 62.0 establishment of cell polarity 0.003 0.09 0.215 11.0 -0.255 50.0 61.0 Nephrin/NEPH1/podocin/NCK1-2 0.029 0.08 0.309 2.0 -0.183 49.0 51.0 Nephrin/NEPH1/beta Arrestin2 0.016 0.069 0.198 9.0 -0.175 49.0 58.0 NPHS1 0.02 0.054 0.289 13.0 -9999.0 0.0 13.0 Nephrin/NEPH1/podocin 0.014 0.072 0.2 12.0 -0.184 49.0 61.0 TJP1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.021 0.023 -9999.0 0.0 -0.349 2.0 2.0 NCK2 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.021 0.076 0.349 1.0 -0.191 48.0 49.0 CD2AP 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.02 0.076 0.241 4.0 -0.188 49.0 53.0 GRB2 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.007 0.126 0.234 91.0 -0.202 64.0 155.0 cytoskeleton organization -0.016 0.079 0.216 19.0 -0.218 47.0 66.0 Nephrin/NEPH1 0.007 0.064 0.177 11.0 -0.171 50.0 61.0 Nephrin/NEPH1/ZO-1 0.014 0.077 0.204 11.0 -0.201 50.0 61.0