Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.042 0.156 -9999.0 0.0 -0.536 31.0 31.0 IHH -0.041 0.211 0.31 57.0 -0.382 121.0 178.0 SHH Np/Cholesterol/GAS1 -0.084 0.102 0.23 1.0 -0.186 254.0 255.0 LRPAP1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.083 0.102 0.185 254.0 -0.228 1.0 255.0 SMO/beta Arrestin2 -0.039 0.159 -9999.0 0.0 -0.313 106.0 106.0 SMO -0.057 0.155 -9999.0 0.0 -0.326 109.0 109.0 AKT1 -0.019 0.124 -9999.0 0.0 -0.473 21.0 21.0 ARRB2 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.01 0.066 -9999.0 0.0 -0.349 17.0 17.0 ADRBK1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.056 0.153 -9999.0 0.0 -0.322 109.0 109.0 STIL -0.01 0.118 0.186 56.0 -0.277 28.0 84.0 DHH N/PTCH2 -0.004 0.098 -9999.0 0.0 -0.258 65.0 65.0 DHH N/PTCH1 -0.043 0.133 -9999.0 0.0 -0.242 126.0 126.0 PIK3CA 0.02 0.018 -9999.0 0.0 -0.349 1.0 1.0 DHH -0.007 0.1 -9999.0 0.0 -0.349 41.0 41.0 PTHLH -0.062 0.191 -9999.0 0.0 -0.578 33.0 33.0 determination of left/right symmetry -0.056 0.153 -9999.0 0.0 -0.322 109.0 109.0 PIK3R1 0.018 0.037 -9999.0 0.0 -0.349 5.0 5.0 skeletal system development -0.061 0.189 -9999.0 0.0 -0.572 33.0 33.0 IHH N/Hhip -0.004 0.143 0.22 72.0 -0.23 118.0 190.0 DHH N/Hhip 0.017 0.09 0.208 26.0 -0.243 46.0 72.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.056 0.153 -9999.0 0.0 -0.322 109.0 109.0 pancreas development 0.032 0.069 0.279 28.0 -0.349 5.0 33.0 HHAT 0.017 0.033 -9999.0 0.0 -0.349 4.0 4.0 PI3K 0.026 0.03 -9999.0 0.0 -0.245 5.0 5.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.203 0.181 -9999.0 0.0 -0.349 313.0 313.0 somite specification -0.056 0.153 -9999.0 0.0 -0.322 109.0 109.0 SHH Np/Cholesterol/PTCH1 -0.022 0.11 0.241 5.0 -0.242 49.0 54.0 SHH Np/Cholesterol/PTCH2 0.015 0.06 0.225 6.0 -0.197 27.0 33.0 SHH Np/Cholesterol/Megalin 0.079 0.095 0.205 168.0 -0.176 6.0 174.0 SHH 0.004 0.059 0.131 62.0 -0.246 6.0 68.0 catabolic process -0.037 0.127 -9999.0 0.0 -0.252 124.0 124.0 SMO/Vitamin D3 -0.015 0.15 0.273 12.0 -0.259 114.0 126.0 SHH Np/Cholesterol/Hhip 0.03 0.06 0.206 33.0 -0.184 11.0 44.0 LRP2 0.111 0.123 0.28 179.0 -9999.0 0.0 179.0 receptor-mediated endocytosis -0.009 0.14 0.233 11.0 -0.319 32.0 43.0 SHH Np/Cholesterol/BOC 0.017 0.054 0.225 6.0 -0.193 22.0 28.0 SHH Np/Cholesterol/CDO 0.005 0.07 0.225 6.0 -0.19 47.0 53.0 mesenchymal cell differentiation -0.03 0.059 0.183 11.0 -0.203 33.0 44.0 mol:Vitamin D3 0.0 0.135 0.293 16.0 -0.281 31.0 47.0 IHH N/PTCH2 -0.022 0.147 0.199 56.0 -0.25 130.0 186.0 CDON -0.015 0.112 -9999.0 0.0 -0.349 52.0 52.0 IHH N/PTCH1 -0.026 0.147 -9999.0 0.0 -0.254 124.0 124.0 Megalin/LRPAP1 0.09 0.084 0.209 172.0 -9999.0 0.0 172.0 PTCH2 0.002 0.084 -9999.0 0.0 -0.349 28.0 28.0 SHH Np/Cholesterol 0.008 0.023 -9999.0 0.0 -0.183 6.0 6.0 PTCH1 -0.037 0.127 -9999.0 0.0 -0.253 124.0 124.0 HHIP 0.032 0.069 0.279 28.0 -0.349 5.0 33.0