Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.013 0.024 -9999.0 0.0 -0.17 8.0 8.0 epithelial cell differentiation 0.041 0.023 -9999.0 0.0 -0.177 2.0 2.0 CYFIP2 0.02 0.028 -9999.0 0.0 -0.349 3.0 3.0 ENAH -0.006 0.057 0.26 13.0 -9999.0 0.0 13.0 EGFR 0.014 0.06 0.329 1.0 -0.349 13.0 14.0 EPHA2 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.012 0.025 0.173 6.0 -9999.0 0.0 6.0 CTNNB1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.043 0.017 -9999.0 0.0 -0.208 1.0 1.0 AQP5 0.077 0.086 0.233 7.0 -0.338 8.0 15.0 CTNND1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.014 0.017 0.169 2.0 -9999.0 0.0 2.0 regulation of calcium-dependent cell-cell adhesion -0.016 0.036 0.17 6.0 -0.319 1.0 7.0 EGF 0.031 0.052 0.279 20.0 -0.349 1.0 21.0 NCKAP1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.001 0.058 -9999.0 0.0 -0.305 15.0 15.0 cortical microtubule organization 0.041 0.023 -9999.0 0.0 -0.177 2.0 2.0 GO:0000145 -0.013 0.016 0.158 2.0 -9999.0 0.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.046 0.024 -9999.0 0.0 -0.178 2.0 2.0 MLLT4 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.02 0.018 -9999.0 0.0 -0.165 4.0 4.0 ARF6 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.043 0.031 -9999.0 0.0 -0.19 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.004 0.017 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.012 0.023 0.171 5.0 -9999.0 0.0 5.0 ARF6/GTP 0.047 0.033 -9999.0 0.0 -0.18 2.0 2.0 CDH1 0.019 0.024 -9999.0 0.0 -0.349 2.0 2.0 EGFR/EGFR/EGF/EGF 0.033 0.043 -9999.0 0.0 -0.181 13.0 13.0 RhoA/GDP 0.042 0.023 -9999.0 0.0 -0.171 2.0 2.0 actin cytoskeleton organization -0.014 0.021 0.159 5.0 -9999.0 0.0 5.0 IGF-1R heterotetramer 0.008 0.07 -9999.0 0.0 -0.349 19.0 19.0 GIT1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.008 0.07 -9999.0 0.0 -0.349 19.0 19.0 IGF1 -0.048 0.146 -9999.0 0.0 -0.349 99.0 99.0 DIAPH1 0.019 0.096 -9999.0 0.0 -0.529 7.0 7.0 Wnt receptor signaling pathway -0.041 0.023 0.177 2.0 -9999.0 0.0 2.0 RHOA 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.02 0.018 -9999.0 0.0 -0.165 4.0 4.0 CTNNA1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.015 0.021 0.16 5.0 -9999.0 0.0 5.0 EFNA1 0.02 0.02 0.304 2.0 -9999.0 0.0 2.0 LPP -0.014 0.023 0.167 5.0 -9999.0 0.0 5.0 Ephrin A1/EPHA2 0.029 0.026 -9999.0 0.0 -0.17 2.0 2.0 SEC6/SEC8 -0.021 0.012 -9999.0 0.0 -0.167 1.0 1.0 MGAT3 -0.016 0.037 0.172 6.0 -0.324 1.0 7.0 HGF/MET -0.002 0.087 -9999.0 0.0 -0.175 95.0 95.0 HGF -0.048 0.145 -9999.0 0.0 -0.349 98.0 98.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.013 0.024 -9999.0 0.0 -0.171 8.0 8.0 actin cable formation 0.047 0.106 0.23 93.0 -0.244 2.0 95.0 KIAA1543 -0.013 0.022 0.162 5.0 -0.165 3.0 8.0 KIFC3 -0.014 0.022 0.171 5.0 -9999.0 0.0 5.0 NCK1 0.021 0.023 -9999.0 0.0 -0.349 2.0 2.0 EXOC3 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.012 0.024 0.173 6.0 -9999.0 0.0 6.0 NCK1/GIT1 0.03 0.02 -9999.0 0.0 -0.245 2.0 2.0 mol:GDP 0.041 0.023 -9999.0 0.0 -0.177 2.0 2.0 EXOC4 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.012 0.024 0.172 6.0 -0.172 2.0 8.0 PIP5K1C -0.014 0.017 0.171 2.0 -9999.0 0.0 2.0 LIMA1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.018 0.087 0.31 17.0 -9999.0 0.0 17.0 adherens junction assembly -0.043 0.139 -9999.0 0.0 -0.558 29.0 29.0 IGF-1R heterotetramer/IGF1 -0.008 0.093 -9999.0 0.0 -0.184 106.0 106.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.021 0.04 0.279 4.0 -0.349 4.0 8.0 PLEKHA7 -0.013 0.024 0.172 5.0 -0.174 1.0 6.0 mol:GTP 0.041 0.03 -9999.0 0.0 -0.189 2.0 2.0 establishment of epithelial cell apical/basal polarity 0.0 0.075 0.342 12.0 -9999.0 0.0 12.0 cortical actin cytoskeleton stabilization 0.013 0.024 -9999.0 0.0 -0.17 8.0 8.0 regulation of cell-cell adhesion -0.014 0.021 0.159 5.0 -9999.0 0.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.013 0.024 -9999.0 0.0 -0.171 8.0 8.0