Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Aurora B signaling	181.0	12182.0	67.0	-0.293	0.37	1000.0	-1000.0	-0.029	-1000.0
Endothelins	122.0	11776.0	96.0	-0.39	0.164	1000.0	-1000.0	-0.03	-1000.0
Aurora C signaling	118.0	827.0	7.0	-0.0	0.228	1000.0	-1000.0	-0.014	-1000.0
Signaling events regulated by Ret tyrosine kinase	113.0	9314.0	82.0	-0.146	0.038	1000.0	-1000.0	-0.032	-1000.0
Angiopoietin receptor Tie2-mediated signaling	104.0	9226.0	88.0	-0.304	0.114	1000.0	-1000.0	-0.047	-1000.0
p75(NTR)-mediated signaling	98.0	12352.0	125.0	-0.166	0.075	1000.0	-1000.0	-0.041	-1000.0
FOXM1 transcription factor network	88.0	4528.0	51.0	-0.284	0.28	1000.0	-1000.0	-0.06	-1000.0
PDGFR-alpha signaling pathway	85.0	3765.0	44.0	-0.276	0.036	1000.0	-1000.0	-0.029	-1000.0
Signaling events mediated by the Hedgehog family	79.0	4155.0	52.0	-0.203	0.111	1000.0	-1000.0	-0.02	-1000.0
Integrins in angiogenesis	78.0	6578.0	84.0	-0.259	0.096	1000.0	-1000.0	-0.02	-1000.0
HIF-1-alpha transcription factor network	77.0	5883.0	76.0	-0.25	0.045	1000.0	-1000.0	-0.027	-1000.0
PLK1 signaling events	75.0	6379.0	85.0	-0.056	0.25	1000.0	-1000.0	-0.033	-1000.0
Reelin signaling pathway	74.0	4190.0	56.0	-0.117	0.045	1000.0	-1000.0	-0.019	-1000.0
Cellular roles of Anthrax toxin	68.0	2666.0	39.0	-0.092	0.053	1000.0	-1000.0	-0.016	-1000.0
Effects of Botulinum toxin	67.0	1746.0	26.0	-0.104	0.114	1000.0	-1000.0	-0.008	-1000.0
S1P3 pathway	65.0	2745.0	42.0	-0.394	0.031	1000.0	-1000.0	-0.02	-1000.0
Nongenotropic Androgen signaling	61.0	3202.0	52.0	-0.231	0.136	1000.0	-1000.0	-0.019	-1000.0
Aurora A signaling	57.0	3457.0	60.0	-0.137	0.22	1000.0	-1000.0	-0.015	-1000.0
IGF1 pathway	55.0	3144.0	57.0	-0.078	0.035	1000.0	-1000.0	-0.02	-1000.0
Fc-epsilon receptor I signaling in mast cells	54.0	5300.0	97.0	-0.096	0.024	1000.0	-1000.0	-0.031	-1000.0
Wnt signaling	54.0	384.0	7.0	-0.066	0.035	1000.0	-1000.0	-0.007	-1000.0
TCGA08_retinoblastoma	52.0	416.0	8.0	-0.04	0.129	1000.0	-1000.0	-0.005	-1000.0
FOXA2 and FOXA3 transcription factor networks	49.0	2263.0	46.0	-0.191	0.183	1000.0	-1000.0	-0.047	-1000.0
TCGA08_p53	49.0	343.0	7.0	-0.033	0.019	1000.0	-1000.0	-0.008	-1000.0
Signaling mediated by p38-alpha and p38-beta	49.0	2175.0	44.0	-0.075	0.023	1000.0	-1000.0	-0.016	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	49.0	5969.0	120.0	-0.152	0.115	1000.0	-1000.0	-0.03	-1000.0
Ephrin B reverse signaling	47.0	2296.0	48.0	-0.092	0.028	1000.0	-1000.0	-0.027	-1000.0
Thromboxane A2 receptor signaling	46.0	4830.0	105.0	-0.133	0.048	1000.0	-1000.0	-0.027	-1000.0
Glypican 1 network	46.0	2221.0	48.0	-0.168	0.102	1000.0	-1000.0	-0.021	-1000.0
LPA4-mediated signaling events	44.0	531.0	12.0	-0.109	0.0	1000.0	-1000.0	-0.016	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	43.0	2944.0	68.0	-0.153	0.075	1000.0	-1000.0	-0.053	-1000.0
S1P4 pathway	43.0	1092.0	25.0	-0.065	0.038	1000.0	-1000.0	-0.013	-1000.0
Noncanonical Wnt signaling pathway	42.0	1114.0	26.0	-0.123	0.035	1000.0	-1000.0	-0.023	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	40.0	1392.0	34.0	-0.017	0.029	1000.0	-1000.0	-0.025	-1000.0
BMP receptor signaling	40.0	3270.0	81.0	-0.23	0.043	1000.0	-1000.0	-0.026	-1000.0
Plasma membrane estrogen receptor signaling	40.0	3474.0	86.0	-0.192	0.081	1000.0	-1000.0	-0.027	-1000.0
amb2 Integrin signaling	39.0	3198.0	82.0	-0.104	0.128	1000.0	-1000.0	-0.017	-1000.0
S1P5 pathway	39.0	673.0	17.0	-0.065	0.036	1000.0	-1000.0	-0.003	-1000.0
Syndecan-1-mediated signaling events	37.0	1271.0	34.0	-0.048	0.158	1000.0	-1000.0	-0.02	-1000.0
LPA receptor mediated events	37.0	3826.0	102.0	-0.134	0.128	1000.0	-1000.0	-0.049	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	37.0	2951.0	78.0	-0.136	0.056	1000.0	-1000.0	-0.047	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	35.0	2975.0	85.0	-0.206	0.031	1000.0	-1000.0	-0.034	-1000.0
Osteopontin-mediated events	34.0	1308.0	38.0	-0.087	0.096	1000.0	-1000.0	-0.019	-1000.0
Ephrin A  reverse signaling	34.0	241.0	7.0	-0.026	0.013	1000.0	-1000.0	-0.007	-1000.0
EPHB forward signaling	33.0	2869.0	85.0	-0.055	0.048	1000.0	-1000.0	-0.044	-1000.0
Ras signaling in the CD4+ TCR pathway	32.0	548.0	17.0	-0.09	0.023	1000.0	-1000.0	-0.017	-1000.0
S1P1 pathway	31.0	1129.0	36.0	-0.149	0.022	1000.0	-1000.0	-0.03	-1000.0
Arf6 signaling events	30.0	1880.0	62.0	-0.061	0.043	1000.0	-1000.0	-0.016	-1000.0
IL4-mediated signaling events	30.0	2765.0	91.0	-0.302	0.092	1000.0	-1000.0	-0.098	-1000.0
Glucocorticoid receptor regulatory network	29.0	3382.0	114.0	-0.149	0.206	1000.0	-1000.0	-0.035	-1000.0
Visual signal transduction: Rods	29.0	1542.0	52.0	-0.057	0.112	1000.0	-1000.0	-0.015	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	28.0	1565.0	54.0	-0.1	0.048	1000.0	-1000.0	-0.025	-1000.0
HIF-2-alpha transcription factor network	28.0	1218.0	43.0	-0.165	0.076	1000.0	-1000.0	-0.042	-1000.0
EGFR-dependent Endothelin signaling events	28.0	601.0	21.0	-0.083	0.047	1000.0	-1000.0	-0.027	-1000.0
FAS signaling pathway (CD95)	26.0	1246.0	47.0	-0.048	0.038	1000.0	-1000.0	-0.027	-1000.0
Insulin Pathway	26.0	1959.0	74.0	-0.097	0.114	1000.0	-1000.0	-0.031	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	25.0	1323.0	52.0	-0.055	0.047	1000.0	-1000.0	-0.022	-1000.0
Glypican 2 network	25.0	102.0	4.0	0.023	0.043	1000.0	-1000.0	0.016	-1000.0
TCGA08_rtk_signaling	25.0	654.0	26.0	-0.096	0.032	1000.0	-1000.0	-0.01	-1000.0
Coregulation of Androgen receptor activity	24.0	1883.0	76.0	-0.09	0.124	1000.0	-1000.0	-0.018	-1000.0
Visual signal transduction: Cones	24.0	939.0	38.0	-0.057	0.033	1000.0	-1000.0	-0.014	-1000.0
Syndecan-2-mediated signaling events	24.0	1705.0	69.0	-0.01	0.102	1000.0	-1000.0	-0.027	-1000.0
Presenilin action in Notch and Wnt signaling	24.0	1477.0	61.0	-0.087	0.083	1000.0	-1000.0	-0.035	-1000.0
TCR signaling in naïve CD8+ T cells	24.0	2246.0	93.0	-0.014	0.052	1000.0	-1000.0	-0.034	-1000.0
Syndecan-4-mediated signaling events	24.0	1659.0	67.0	-0.204	0.128	1000.0	-1000.0	-0.025	-1000.0
Signaling events mediated by PTP1B	23.0	1791.0	76.0	-0.089	0.037	1000.0	-1000.0	-0.025	-1000.0
Calcium signaling in the CD4+ TCR pathway	23.0	726.0	31.0	-0.088	0.042	1000.0	-1000.0	-0.026	-1000.0
Regulation of Androgen receptor activity	23.0	1635.0	70.0	-0.039	0.191	1000.0	-1000.0	-0.022	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	22.0	2858.0	125.0	-0.054	0.044	1000.0	-1000.0	-0.025	-1000.0
IL6-mediated signaling events	22.0	1701.0	75.0	-0.086	0.089	1000.0	-1000.0	-0.028	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	22.0	740.0	33.0	-0.122	0.125	1000.0	-1000.0	-0.025	-1000.0
Canonical Wnt signaling pathway	21.0	1102.0	51.0	-0.048	0.083	1000.0	-1000.0	-0.034	-1000.0
IL2 signaling events mediated by STAT5	21.0	467.0	22.0	-0.096	0.076	1000.0	-1000.0	-0.023	-1000.0
BCR signaling pathway	21.0	2176.0	99.0	-0.038	0.058	1000.0	-1000.0	-0.037	-1000.0
BARD1 signaling events	20.0	1186.0	57.0	-0.045	0.132	1000.0	-1000.0	-0.039	-1000.0
Hedgehog signaling events mediated by Gli proteins	20.0	1315.0	65.0	-0.093	0.052	1000.0	-1000.0	-0.028	-1000.0
mTOR signaling pathway	20.0	1072.0	53.0	-0.029	0.025	1000.0	-1000.0	-0.024	-1000.0
EPO signaling pathway	19.0	1078.0	55.0	-0.042	0.039	1000.0	-1000.0	-0.019	-1000.0
Class I PI3K signaling events mediated by Akt	19.0	1306.0	68.0	-0.082	0.206	1000.0	-1000.0	-0.017	-1000.0
Regulation of p38-alpha and p38-beta	19.0	1074.0	54.0	-0.133	0.053	1000.0	-1000.0	-0.036	-1000.0
IFN-gamma pathway	18.0	1243.0	68.0	-0.179	0.073	1000.0	-1000.0	-0.03	-1000.0
Nectin adhesion pathway	18.0	1179.0	63.0	-0.038	0.054	1000.0	-1000.0	-0.021	-1000.0
IL1-mediated signaling events	18.0	1140.0	62.0	-0.026	0.068	1000.0	-1000.0	-0.024	-1000.0
Regulation of nuclear SMAD2/3 signaling	17.0	2364.0	136.0	-0.086	0.138	1000.0	-1000.0	-0.027	-1000.0
IL12-mediated signaling events	17.0	1539.0	87.0	-0.288	0.06	1000.0	-1000.0	-0.045	-1000.0
Retinoic acid receptors-mediated signaling	17.0	1008.0	58.0	-0.017	0.05	1000.0	-1000.0	-0.02	-1000.0
Syndecan-3-mediated signaling events	17.0	601.0	35.0	-0.06	0.097	1000.0	-1000.0	-0.012	-1000.0
Rapid glucocorticoid signaling	17.0	351.0	20.0	-0.031	0.026	1000.0	-1000.0	-0.009	-1000.0
IL2 signaling events mediated by PI3K	16.0	941.0	58.0	-0.033	0.117	1000.0	-1000.0	-0.026	-1000.0
PDGFR-beta signaling pathway	16.0	1605.0	97.0	-0.021	0.049	1000.0	-1000.0	-0.034	-1000.0
ErbB2/ErbB3 signaling events	15.0	1025.0	65.0	-0.073	0.048	1000.0	-1000.0	-0.041	-1000.0
Sphingosine 1-phosphate (S1P) pathway	15.0	436.0	28.0	-0.065	0.041	1000.0	-1000.0	-0.015	-1000.0
Insulin-mediated glucose transport	15.0	499.0	32.0	-0.083	0.206	1000.0	-1000.0	-0.018	-1000.0
FoxO family signaling	15.0	1005.0	64.0	-0.016	0.206	1000.0	-1000.0	-0.031	-1000.0
Regulation of Telomerase	15.0	1573.0	102.0	-0.241	0.086	1000.0	-1000.0	-0.036	-1000.0
IL23-mediated signaling events	15.0	922.0	60.0	-0.007	0.232	1000.0	-1000.0	-0.051	-1000.0
JNK signaling in the CD4+ TCR pathway	14.0	249.0	17.0	-0.045	0.056	1000.0	-1000.0	-0.014	-1000.0
Ceramide signaling pathway	14.0	1096.0	76.0	-0.048	0.06	1000.0	-1000.0	-0.025	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	14.0	640.0	45.0	-0.005	0.057	1000.0	-1000.0	-0.032	-1000.0
Signaling events mediated by PRL	14.0	483.0	34.0	-0.037	0.091	1000.0	-1000.0	-0.029	-1000.0
Caspase cascade in apoptosis	13.0	1020.0	74.0	-0.029	0.148	1000.0	-1000.0	-0.026	-1000.0
ceramide signaling pathway	13.0	644.0	49.0	-0.01	0.054	1000.0	-1000.0	-0.027	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	13.0	1156.0	83.0	-0.022	0.206	1000.0	-1000.0	-0.019	-1000.0
ErbB4 signaling events	12.0	833.0	69.0	-0.049	0.055	1000.0	-1000.0	-0.025	-1000.0
E-cadherin signaling in keratinocytes	12.0	529.0	43.0	-0.008	0.038	1000.0	-1000.0	-0.016	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	11.0	411.0	37.0	-0.021	0.063	1000.0	-1000.0	-0.015	-1000.0
Signaling mediated by p38-gamma and p38-delta	11.0	170.0	15.0	-0.011	0.022	1000.0	-1000.0	-0.017	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	11.0	852.0	74.0	-0.048	0.077	1000.0	-1000.0	-0.045	-1000.0
IL27-mediated signaling events	10.0	555.0	51.0	-0.032	0.039	1000.0	-1000.0	-0.028	-1000.0
E-cadherin signaling in the nascent adherens junction	10.0	799.0	76.0	-0.03	0.056	1000.0	-1000.0	-0.035	-1000.0
Class IB PI3K non-lipid kinase events	10.0	30.0	3.0	-0.022	0.022	1000.0	-1000.0	-0.02	-1000.0
Canonical NF-kappaB pathway	9.0	374.0	39.0	-0.008	0.053	1000.0	-1000.0	-0.017	-1000.0
Signaling events mediated by HDAC Class III	9.0	386.0	40.0	-0.052	0.04	1000.0	-1000.0	-0.03	-1000.0
Signaling events mediated by HDAC Class II	7.0	564.0	75.0	-0.033	0.044	1000.0	-1000.0	-0.02	-1000.0
Arf6 trafficking events	7.0	500.0	71.0	-0.155	0.041	1000.0	-1000.0	-0.032	-1000.0
p38 MAPK signaling pathway	7.0	343.0	44.0	-0.003	0.064	1000.0	-1000.0	-0.018	-1000.0
Class I PI3K signaling events	6.0	446.0	73.0	-0.023	0.042	1000.0	-1000.0	-0.023	-1000.0
Signaling events mediated by HDAC Class I	5.0	558.0	104.0	-0.035	0.057	1000.0	-1000.0	-0.035	-1000.0
Arf6 downstream pathway	4.0	173.0	43.0	-0.037	0.041	1000.0	-1000.0	-0.024	-1000.0
TRAIL signaling pathway	4.0	238.0	48.0	-0.01	0.049	1000.0	-1000.0	-0.019	-1000.0
Paxillin-dependent events mediated by a4b1	4.0	170.0	36.0	-0.041	0.043	1000.0	-1000.0	-0.028	-1000.0
VEGFR1 specific signals	4.0	259.0	56.0	-0.041	0.047	1000.0	-1000.0	-0.025	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	3.0	77.0	23.0	0.002	0.045	1000.0	-1000.0	-0.022	-1000.0
PLK2 and PLK4 events	3.0	11.0	3.0	-0.011	0.025	1000.0	-1000.0	-0.013	-1000.0
Arf1 pathway	3.0	180.0	54.0	-0.006	0.041	1000.0	-1000.0	-0.009	-1000.0
a4b1 and a4b7 Integrin signaling	2.0	10.0	5.0	0.022	0.033	1000.0	-1000.0	0.018	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	2.0	56.0	27.0	-0.013	0.054	1000.0	-1000.0	-0.025	-1000.0
Atypical NF-kappaB pathway	1.0	48.0	31.0	-0.011	0.026	1000.0	-1000.0	-0.016	-1000.0
E-cadherin signaling events	1.0	7.0	5.0	0.019	0.038	1000.0	-1000.0	0.018	-1000.0
Circadian rhythm pathway	0.0	16.0	22.0	-0.005	0.048	1000.0	-1000.0	-0.031	-1000.0
Alternative NF-kappaB pathway	0.0	2.0	13.0	-0.0	0.059	1000.0	-1000.0	-0.0	-1000.0
Total	4152	248807	7203	-11.6765637425	10.3374094826	131000	-131000	-3.24536972462	-131000