Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.091 0.166 -9999.0 0.0 -0.521 5.0 5.0 IHH -0.057 0.141 -9999.0 0.0 -0.32 10.0 10.0 SHH Np/Cholesterol/GAS1 -0.039 0.085 -9999.0 0.0 -0.177 14.0 14.0 LRPAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.039 0.085 0.176 14.0 -9999.0 0.0 14.0 SMO/beta Arrestin2 -0.104 0.18 -9999.0 0.0 -0.366 10.0 10.0 SMO -0.114 0.178 -9999.0 0.0 -0.383 10.0 10.0 AKT1 -0.061 0.158 -9999.0 0.0 -0.532 4.0 4.0 ARRB2 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.019 0.025 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.112 0.176 -9999.0 0.0 -0.378 10.0 10.0 STIL -0.068 0.141 0.191 2.0 -0.299 9.0 11.0 DHH N/PTCH2 0.04 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.068 0.13 -9999.0 0.0 -0.26 9.0 9.0 PIK3CA 0.019 0.05 -9999.0 0.0 -0.341 1.0 1.0 DHH 0.028 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.128 0.207 -9999.0 0.0 -0.548 6.0 6.0 determination of left/right symmetry -0.112 0.176 -9999.0 0.0 -0.378 10.0 10.0 PIK3R1 -0.006 0.098 -9999.0 0.0 -0.341 4.0 4.0 skeletal system development -0.127 0.205 -9999.0 0.0 -0.543 6.0 6.0 IHH N/Hhip -0.105 0.138 -9999.0 0.0 -0.254 22.0 22.0 DHH N/Hhip 0.0 0.088 -9999.0 0.0 -0.237 6.0 6.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.112 0.176 -9999.0 0.0 -0.378 10.0 10.0 pancreas development -0.023 0.116 -9999.0 0.0 -0.34 6.0 6.0 HHAT -0.026 0.123 -9999.0 0.0 -0.341 7.0 7.0 PI3K 0.013 0.083 -9999.0 0.0 -0.302 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.047 0.136 -9999.0 0.0 -0.341 9.0 9.0 somite specification -0.112 0.176 -9999.0 0.0 -0.378 10.0 10.0 SHH Np/Cholesterol/PTCH1 -0.079 0.133 -9999.0 0.0 -0.281 12.0 12.0 SHH Np/Cholesterol/PTCH2 -0.005 0.068 -9999.0 0.0 -0.176 7.0 7.0 SHH Np/Cholesterol/Megalin -0.008 0.068 -9999.0 0.0 -0.178 7.0 7.0 SHH -0.018 0.079 -9999.0 0.0 -0.237 6.0 6.0 catabolic process -0.081 0.136 -9999.0 0.0 -0.292 9.0 9.0 SMO/Vitamin D3 -0.074 0.171 -9999.0 0.0 -0.346 10.0 10.0 SHH Np/Cholesterol/Hhip -0.029 0.087 -9999.0 0.0 -0.19 11.0 11.0 LRP2 0.021 0.021 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.08 0.168 -9999.0 0.0 -0.401 7.0 7.0 SHH Np/Cholesterol/BOC -0.004 0.064 -9999.0 0.0 -0.178 6.0 6.0 SHH Np/Cholesterol/CDO -0.007 0.068 -9999.0 0.0 -0.178 7.0 7.0 mesenchymal cell differentiation 0.029 0.087 0.189 11.0 -9999.0 0.0 11.0 mol:Vitamin D3 -0.065 0.153 0.211 2.0 -0.282 12.0 14.0 IHH N/PTCH2 -0.067 0.113 -9999.0 0.0 -0.217 18.0 18.0 CDON 0.023 0.018 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.088 0.14 -9999.0 0.0 -0.248 21.0 21.0 Megalin/LRPAP1 0.033 0.021 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.011 0.064 -9999.0 0.0 -0.174 7.0 7.0 PTCH1 -0.081 0.136 -9999.0 0.0 -0.292 9.0 9.0 HHIP -0.023 0.116 -9999.0 0.0 -0.341 6.0 6.0