Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.01 0.073 -9999.0 0.0 -0.207 6.0 6.0 epithelial cell differentiation 0.015 0.083 -9999.0 0.0 -0.213 6.0 6.0 CYFIP2 0.018 0.058 -9999.0 0.0 -0.413 1.0 1.0 ENAH 0.005 0.092 0.266 3.0 -9999.0 0.0 3.0 EGFR 0.013 0.061 -9999.0 0.0 -0.413 1.0 1.0 EPHA2 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.034 0.071 0.173 1.0 -0.208 7.0 8.0 CTNNB1 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.044 0.041 -9999.0 0.0 -0.251 1.0 1.0 AQP5 -0.061 0.162 -9999.0 0.0 -0.467 7.0 7.0 CTNND1 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.031 0.066 0.171 1.0 -0.205 6.0 7.0 regulation of calcium-dependent cell-cell adhesion -0.034 0.07 0.171 1.0 -0.205 7.0 8.0 EGF 0.006 0.083 -9999.0 0.0 -0.413 2.0 2.0 NCKAP1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.018 0.092 -9999.0 0.0 -0.595 1.0 1.0 cortical microtubule organization 0.015 0.083 -9999.0 0.0 -0.213 6.0 6.0 GO:0000145 -0.03 0.063 0.159 1.0 -0.196 6.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.019 0.086 -9999.0 0.0 -0.215 6.0 6.0 MLLT4 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.032 0.047 -9999.0 0.0 -0.195 4.0 4.0 ARF6 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.05 0.029 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.02 0.063 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.031 0.067 0.173 1.0 -0.208 6.0 7.0 ARF6/GTP 0.053 0.032 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.031 0.145 -9999.0 0.0 -0.413 7.0 7.0 EGFR/EGFR/EGF/EGF 0.0 0.099 -9999.0 0.0 -0.227 8.0 8.0 RhoA/GDP 0.017 0.083 -9999.0 0.0 -0.211 6.0 6.0 actin cytoskeleton organization -0.036 0.069 0.16 1.0 -0.207 6.0 7.0 IGF-1R heterotetramer -0.006 0.113 -9999.0 0.0 -0.412 4.0 4.0 GIT1 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.006 0.113 -9999.0 0.0 -0.413 4.0 4.0 IGF1 -0.019 0.115 -9999.0 0.0 -0.413 4.0 4.0 DIAPH1 0.022 0.128 -9999.0 0.0 -0.622 1.0 1.0 Wnt receptor signaling pathway -0.015 0.083 0.213 6.0 -9999.0 0.0 6.0 RHOA 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.032 0.049 -9999.0 0.0 -0.204 4.0 4.0 CTNNA1 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.037 0.07 0.161 1.0 -0.211 6.0 7.0 EFNA1 0.022 0.009 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.031 0.064 0.163 1.0 -0.201 6.0 7.0 Ephrin A1/EPHA2 0.014 0.066 -9999.0 0.0 -0.204 4.0 4.0 SEC6/SEC8 -0.036 0.052 -9999.0 0.0 -0.2 5.0 5.0 MGAT3 -0.035 0.071 0.173 1.0 -0.208 7.0 8.0 HGF/MET -0.026 0.128 -9999.0 0.0 -0.245 13.0 13.0 HGF -0.049 0.144 -9999.0 0.0 -0.413 7.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.007 0.07 -9999.0 0.0 -0.209 6.0 6.0 actin cable formation 0.03 0.101 0.271 5.0 -9999.0 0.0 5.0 KIAA1543 -0.051 0.101 0.16 1.0 -0.263 9.0 10.0 KIFC3 -0.031 0.066 0.173 1.0 -0.208 6.0 7.0 NCK1 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.032 0.067 0.173 1.0 -0.208 6.0 7.0 NCK1/GIT1 0.034 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.015 0.083 -9999.0 0.0 -0.213 6.0 6.0 EXOC4 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.034 0.061 -9999.0 0.0 -0.208 6.0 6.0 PIP5K1C -0.031 0.067 0.173 1.0 -0.208 6.0 7.0 LIMA1 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.008 0.101 0.286 3.0 -9999.0 0.0 3.0 adherens junction assembly -0.079 0.166 -9999.0 0.0 -0.453 7.0 7.0 IGF-1R heterotetramer/IGF1 -0.019 0.13 -9999.0 0.0 -0.259 11.0 11.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.035 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.002 0.099 -9999.0 0.0 -0.413 3.0 3.0 PLEKHA7 -0.052 0.107 0.173 1.0 -0.276 9.0 10.0 mol:GTP 0.048 0.028 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.023 0.074 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.01 0.073 -9999.0 0.0 -0.207 6.0 6.0 regulation of cell-cell adhesion -0.036 0.069 0.16 1.0 -0.207 6.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.007 0.07 -9999.0 0.0 -0.209 6.0 6.0