		Clinical Features	CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL		MIRSEQ_MATURE_CNMF		MIRSEQ_MATURE_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
ZFPM1	24 (39%)	38	0.80129	1	0.81627	1	0.71582	1	0.87168	1	0.37475	1	0.74459	1	0.8215	1	0.9225	1	0.38151	1	0.74173	1
LACTB	19 (31%)	43	0.43646	1	0.69064	1	0.65998	1	0.56607	1	1	1	0.31608	1	0.37753	1	0.75224	1	0.32038	1	0.17846	1
CCDC102A	17 (27%)	45	0.01901	1	0.93583	1	0.88012	1	0.50675	1	0.97466	1	0.82576	1	0.49723	1	0.46941	1	0.80534	1	0.50653	1
ZNF517	13 (21%)	49	0.16638	1	0.98003	1	NA	NA	NA	NA	0.81964	1	0.95119	1	0.17302	1	0.69819	1	0.72649	1	0.7725	1
MAL2	11 (18%)	51	0.49933	1	0.31303	1	0.20877	1	1	1	0.25318	1	0.50941	1	0.21794	1	0.26836	1	1	1	0.86748	1
CLDN23	10 (16%)	52	0.57171	1	0.24908	1	1	1	0.34917	1	0.02969	1	0.2111	1	0.098449	1	0.18182	1	0.41647	1	0.54226	1
TOR3A	12 (19%)	50	0.61021	1	0.01363	1	0.13795	1	0.31545	1	0.67853	1	0.005	1	1	1	0.84448	1	0.91198	1	0.8078	1
USP42	15 (24%)	47	0.5485	1	0.04692	1	1	1	0.46582	1	1	1	0.96027	1	0.45655	1	0.8726	1	0.91127	1	0.9025	1
TP53	12 (19%)	50	0.13303	1	0.79251	1	0.067989	1	0.4658	1	0.02013	1	0.66655	1	0.01582	1	0.67203	1	0.0061399	1	0.17817	1
APOE	7 (11%)	55	1	1	0.59291	1	0.58914	1	0.38382	1	0.060159	1	0.40086	1	0.19465	1	0.79052	1	0.4156	1	1	1
ZAR1	11 (18%)	51	0.64452	1	0.66963	1	0.20939	1	0.79255	1	0.62361	1	0.86863	1	0.71587	1	0.97182	1	1	1	0.60298	1
ASPDH	8 (13%)	54	0.30067	1	0.68819	1	0.71653	1	0.31426	1	0.02364	1	0.39771	1	0.47364	1	0.03102	1	0.21327	1	0.080999	1
KCNK17	9 (15%)	53	0.20103	1	0.03909	1	0.17899	1	0.43906	1	0.10433	1	0.0094199	1	0.89147	1	0.54797	1	0.71668	1	0.44423	1
LZTR1	6 (10%)	56	0.051729	1	0.85066	1	NA	NA	NA	NA	0.089639	1	0.1197	1	0.40128	1	0.01432	1	1	1	0.45293	1
ERCC2	10 (16%)	52	1	1	0.23243	1	0.21848	1	0.23278	1	0.4816	1	0.17215	1	0.59736	1	0.26787	1	0.33653	1	0.20732	1
RINL	8 (13%)	54	0.33913	1	0.67755	1	0.52797	1	0.57862	1	0.46409	1	0.27276	1	0.7601	1	0.16937	1	0.34498	1	0.74794	1
SYT8	8 (13%)	54	0.44315	1	0.44105	1	1	1	1	1	0.04155	1	0.17657	1	1	1	0.18489	1	0.75075	1	0.49568	1
LRIG1	16 (26%)	46	0.54233	1	0.95968	1	0.21134	1	1	1	0.86526	1	0.61092	1	0.36161	1	0.43466	1	0.57737	1	0.90222	1
C1ORF106	9 (15%)	53	0.84297	1	0.47146	1	0.16406	1	0.04752	1	0.34025	1	0.76125	1	0.47403	1	0.6927	1	0.052979	1	1	1
GPRIN2	8 (13%)	54	0.86749	1	0.3813	1	0.21045	1	0.69321	1	0.68221	1	0.40159	1	0.57775	1	0.75381	1	0.59396	1	0.18263	1
CTNNB1	7 (11%)	55	0.73091	1	0.1849	1	0.21098	1	0.39529	1	0.01765	1	0.02351	1	0.00078999	0.767	0.17519	1	0.12536	1	0.7127	1
C16ORF3	5 (8%)	57	0.85814	1	0.00075999	0.739	0.59044	1	0.7878	1	0.80041	1	0.8148	1	0.58167	1	1	1	0.72618	1	0.83502	1
CCDC105	6 (10%)	56	1	1	0.0109	1	0.58843	1	0.67646	1	0.93757	1	0.79458	1	1	1	0.053549	1	0.21734	1	0.20754	1
RGS9BP	8 (13%)	54	0.72674	1	0.6315	1	1	1	0.12772	1	1	1	0.93362	1	0.21808	1	0.962	1	0.34298	1	0.75354	1
HHIPL1	6 (10%)	56	0.27604	1	0.43367	1	NA	NA	NA	NA	0.63147	1	0.51287	1	0.20677	1	0.42249	1	0.20065	1	0.33273	1
C10ORF95	6 (10%)	56	0.19915	1	0.3783	1	NA	NA	NA	NA	0.5128	1	1	1	0.48481	1	0.35556	1	1	1	1	1
TSC22D2	8 (13%)	54	0.94703	1	0.54149	1	0.76735	1	0.95442	1	0.78021	1	0.81702	1	0.76142	1	0.42895	1	0.34992	1	1	1
NOXA1	5 (8%)	57	0.14516	1	0.51358	1	NA	NA	NA	NA	0.22239	1	0.4425	1	0.29335	1	0.35314	1	0.25193	1	0.72224	1
THEM4	5 (8%)	57	0.28129	1	0.76924	1	NA	NA	NA	NA	0.43966	1	0.87565	1	0.17909	1	0.10663	1	0.23173	1	0.26083	1
ATXN1	10 (16%)	52	0.55553	1	0.13892	1	0.88724	1	0.91517	1	0.23605	1	0.65792	1	0.28533	1	0.87074	1	0.23544	1	0.31477	1
PLIN5	5 (8%)	57	0.49862	1	0.69608	1	0.45417	1	0.38541	1	0.80031	1	0.66723	1	0.26806	1	0.26472	1	0.51072	1	0.04648	1
OPRD1	12 (19%)	50	0.96814	1	0.43357	1	0.27996	1	0.4782	1	0.7986	1	0.95955	1	0.30003	1	0.61416	1	1	1	0.51017	1
KRTAP4-5	5 (8%)	57	0.63174	1	0.28562	1	NA	NA	NA	NA	0.90924	1	0.87624	1	1	1	0.84342	1	0.43509	1	1	1
C19ORF10	7 (11%)	55	0.78184	1	0.42338	1	0.88652	1	0.38987	1	0.24079	1	0.12416	1	0.55087	1	0.86152	1	0.63826	1	0.71518	1
AATK	6 (10%)	56	0.13862	1	0.33073	1	NA	NA	NA	NA	0.4407	1	0.35629	1	1	1	0.5443	1	1	1	0.61965	1
SARM1	6 (10%)	56	0.20777	1	0.4217	1	0.88591	1	0.694	1	0.17383	1	0.11423	1	0.26601	1	0.83588	1	0.51166	1	0.079279	1
TRIOBP	10 (16%)	52	0.62041	1	0.2292	1	0.45264	1	0.12812	1	1	1	0.11242	1	0.71251	1	0.87084	1	1	1	0.77445	1
ZNF598	12 (19%)	50	0.11076	1	0.31624	1	0.42676	1	0.75046	1	0.48883	1	0.95271	1	1	1	0.22573	1	0.90087	1	1	1
WDR34	5 (8%)	57	0.63277	1	0.83061	1	NA	NA	NA	NA	0.8629	1	0.81509	1	0.8421	1	0.55111	1	0.8422	1	0.33552	1
ZNF628	7 (11%)	55	0.21034	1	0.92692	1	0.5908	1	0.67468	1	0.3129	1	0.11655	1	0.094659	1	0.50274	1	0.28592	1	0.54492	1
BTBD11	6 (10%)	56	1	1	0.31533	1	NA	NA	NA	NA	0.48398	1	1	1	0.48771	1	0.18326	1	0.72558	1	0.32963	1
IRX3	5 (8%)	57	0.14111	1	0.70661	1	NA	NA	NA	NA	0.52243	1	0.1199	1	0.17913	1	0.77885	1	0.23054	1	0.45329	1
FPGS	5 (8%)	57	1	1	1	1	0.45164	1	0.3508	1	0.66486	1	0.60107	1	0.055269	1	0.62714	1	0.82207	1	0.61981	1
MEN1	5 (8%)	57	0.41813	1	0.04867	1	NA	NA	NA	NA	0.01314	1	0.0068299	1	0.20635	1	0.04262	1	0.1363	1	0.20113	1
BHLHE22	5 (8%)	57	0.42538	1	0.071939	1	0.88858	1	0.91639	1	0.11979	1	0.81671	1	0.58214	1	0.83598	1	0.72679	1	0.83622	1
DMKN	3 (5%)	59	1	1	0.32475	1	NA	NA	NA	NA	0.61705	1	0.44076	1	0.0062199	1	0.56842	1	0.25403	1	1	1
OBSCN	18 (29%)	44	0.30998	1	0.51987	1	1	1	0.54469	1	0.67171	1	0.80679	1	0.14838	1	0.49779	1	1	1	0.38603	1
PANK2	5 (8%)	57	0.62783	1	0.43145	1	0.45052	1	0.34847	1	0.11492	1	0.051969	1	0.42921	1	0.34974	1	1	1	0.25526	1
RREB1	5 (8%)	57	0.72729	1	0.85084	1	NA	NA	NA	NA	0.6191	1	1	1	0.52799	1	0.54667	1	0.17381	1	0.35223	1
RNF149	4 (6%)	58	0.33873	1	0.03673	1	0.76581	1	0.95381	1	0.43737	1	0.60004	1	0.31769	1	0.25856	1	0.66314	1	0.17435	1
GLTPD2	6 (10%)	56	0.8773	1	0.84246	1	NA	NA	NA	NA	0.82866	1	0.39872	1	0.5512	1	0.53084	1	0.87273	1	0.13174	1
SNED1	5 (8%)	57	0.62939	1	0.31365	1	NA	NA	NA	NA	0.40019	1	0.66612	1	0.094269	1	0.66165	1	1	1	0.5435	1
TPO	12 (19%)	50	0.26233	1	0.30262	1	0.8868	1	0.69661	1	0.17426	1	0.12512	1	0.098109	1	0.34138	1	1	1	0.16965	1
PTPLA	4 (6%)	58	0.41812	1	0.32498	1	NA	NA	NA	NA	0.33614	1	0.44335	1	0.77648	1	1	1	0.77438	1	1	1
PRSS27	3 (5%)	59	1	1	0.90961	1	NA	NA	NA	NA	0.61948	1	0.050559	1	0.13096	1	1	1	0.61401	1	0.5569	1
CD320	4 (6%)	58	1	1	0.85277	1	NA	NA	NA	NA	0.73788	1	0.65859	1	0.39992	1	0.22521	1	0.23156	1	0.26076	1
SEMA5B	8 (13%)	54	0.34176	1	0.26878	1	0.62442	1	0.1741	1	0.3974	1	0.21469	1	0.64994	1	0.29901	1	0.36192	1	0.40787	1
CCDC150	4 (6%)	58	0.18002	1	0.85128	1	1	1	0.60066	1	0.23806	1	0.11693	1	0.40026	1	0.2095	1	1	1	0.45411	1
TAF5	4 (6%)	58	1	1	0.76915	1	1	1	0.95344	1	1	1	0.87709	1	0.0092599	1	0.11516	1	0.055489	1	0.01408	1
GARS	19 (31%)	43	0.075359	1	0.092179	1	0.38148	1	0.33485	1	0.34097	1	0.1023	1	0.11845	1	0.40171	1	0.21351	1	0.39942	1
MUC5B	22 (35%)	40	1	1	0.63056	1	0.53038	1	0.80908	1	0.73311	1	0.66974	1	0.71518	1	0.61717	1	1	1	0.53104	1
KIAA1984	4 (6%)	58	0.41815	1	0.70904	1	0.45086	1	0.50522	1	0.12673	1	0.04934	1	0.03135	1	0.58086	1	0.66469	1	0.79304	1
SRPX	3 (5%)	59	0.75302	1	0.11151	1	NA	NA	NA	NA	0.61828	1	1	1	0.77576	1	0.71755	1	1	1	0.40118	1
TNIP2	5 (8%)	57	0.6294	1	0.70841	1	NA	NA	NA	NA	0.73941	1	0.87625	1	1	1	0.41416	1	1	1	0.45274	1
IDUA	8 (13%)	54	0.3811	1	0.8544	1	0.52833	1	0.79361	1	0.50804	1	0.54613	1	0.20223	1	0.43215	1	0.45732	1	0.64505	1
RNF39	5 (8%)	57	0.7259	1	0.37972	1	0.25315	1	0.79362	1	0.1764	1	0.26629	1	0.15824	1	0.6984	1	0.23867	1	0.68561	1
PABPC1	4 (6%)	58	0.4166	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
SCRT1	3 (5%)	59	1	1	0.43005	1	NA	NA	NA	NA	0.47389	1	0.61617	1	0.42644	1	0.7949	1	0.46823	1	1	1
MAP1S	5 (8%)	57	0.15757	1	0.2769	1	0.21019	1	0.4204	1	0.40071	1	1	1	1	1	0.83477	1	0.42031	1	0.83718	1
NF1	7 (11%)	55	0.2512	1	0.90323	1	0.88877	1	0.39163	1	0.35892	1	0.19244	1	0.28152	1	0.88548	1	1	1	0.096649	1
AKAP2	4 (6%)	58	0.10585	1	0.43501	1	0.45396	1	0.67594	1	0.74048	1	0.17183	1	0.52739	1	0.44648	1	0.82385	1	0.34889	1
NOTCH2	5 (8%)	57	0.27873	1	0.89536	1	NA	NA	NA	NA	0.5239	1	0.11839	1	0.03102	1	0.318	1	0.66453	1	0.795	1
FANK1	4 (6%)	58	1	1	0.32349	1	NA	NA	NA	NA	0.85694	1	0.28893	1	0.77667	1	0.23481	1	0.7741	1	0.25363	1
NEFH	6 (10%)	56	0.052289	1	0.17476	1	NA	NA	NA	NA	0.11581	1	0.050949	1	0.39916	1	0.20979	1	0.66309	1	0.45188	1
NPTX1	3 (5%)	59	0.63817	1	1	1	NA	NA	NA	NA	1	1	0.81713	1	0.58121	1	0.79397	1	0.35178	1	0.55805	1
KBTBD13	9 (15%)	53	0.45716	1	0.11667	1	1	1	0.79057	1	0.68601	1	0.11527	1	1	1	0.32898	1	1	1	0.6046	1
RASIP1	6 (10%)	56	0.36071	1	0.34973	1	NA	NA	NA	NA	0.04035	1	0.18789	1	0.055849	1	0.69955	1	0.41678	1	0.71211	1
AR	4 (6%)	58	0.41638	1	0.51604	1	1	1	0.95428	1	0.47361	1	0.44695	1	0.42991	1	1	1	0.25433	1	1	1
KNDC1	9 (15%)	53	0.35321	1	0.066629	1	0.45158	1	0.55255	1	0.02552	1	0.32783	1	0.42056	1	0.36527	1	0.18717	1	0.38458	1
SEZ6L2	8 (13%)	54	0.38054	1	0.66655	1	0.45073	1	0.79125	1	0.82868	1	1	1	0.46531	1	0.62838	1	1	1	0.85242	1
VARS	6 (10%)	56	1	1	0.42242	1	0.45259	1	0.38595	1	0.21641	1	0.065969	1	0.64599	1	0.86247	1	0.75036	1	1	1
IER5	3 (5%)	59	0.20005	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
NMU	5 (8%)	57	0.91452	1	1	1	NA	NA	NA	NA	0.069069	1	0.61257	1	1	1	0.54625	1	0.82325	1	0.62093	1
TMEM189	3 (5%)	59	0.19981	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
ADAD2	4 (6%)	58	0.41942	1	0.57463	1	NA	NA	NA	NA	0.7381	1	0.1732	1	0.0096599	1	0.51183	1	0.056849	1	0.35174	1
PLEC	13 (21%)	49	0.42794	1	0.67053	1	0.19687	1	0.04863	1	0.20435	1	0.71944	1	0.59614	1	0.6334	1	0.14048	1	0.6249	1
RGMB	6 (10%)	56	0.65102	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
CLIC6	5 (8%)	57	0.63101	1	1	1	NA	NA	NA	NA	0.66487	1	0.11838	1	0.17761	1	0.58303	1	0.29353	1	1	1
ZNF814	3 (5%)	59	1	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
DSPP	9 (15%)	53	0.6101	1	0.059689	1	0.88772	1	0.69324	1	1	1	0.48432	1	0.44609	1	0.53998	1	0.9006	1	1	1
AMDHD1	10 (16%)	52	0.65532	1	0.75806	1	1	1	0.3512	1	0.58827	1	0.13806	1	0.17273	1	0.85202	1	0.90123	1	0.68289	1
CRIPAK	10 (16%)	52	0.38538	1	0.92891	1	0.88671	1	0.93467	1	0.48972	1	0.68673	1	0.89537	1	0.33013	1	0.47652	1	0.36424	1
NOM1	6 (10%)	56	1	1	0.31351	1	NA	NA	NA	NA	0.86547	1	1	1	1	1	0.78773	1	0.42178	1	1	1
MAP7	3 (5%)	59	1	1	0.653	1	NA	NA	NA	NA	1	1	0.81256	1	0.58099	1	0.79345	1	1	1	0.55321	1
PTX4	3 (5%)	59	1	1	1	1	NA	NA	NA	NA	0.47195	1	0.19454	1	0.43049	1	1	1	0.25271	1	0.2553	1
LRP11	6 (10%)	56	1	1	0.079699	1	NA	NA	NA	NA	0.8003	1	0.66412	1	0.58145	1	0.93554	1	0.84205	1	0.83826	1
PDCD6	3 (5%)	59	0.29913	1	0.65105	1	NA	NA	NA	NA	NA	NA	NA	NA	1	1	0.64084	1	1	1	1	1
SHOX2	3 (5%)	59	0.41276	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
UQCRFS1	5 (8%)	57	0.75028	1	0.58655	1	NA	NA	NA	NA	1	1	0.87574	1	0.48895	1	0.20246	1	0.84251	1	0.33385	1
CTBP2	3 (5%)	59	0.75389	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
PRKAR1A	6 (10%)	56	0.61788	1	1	1	0.88635	1	0.7927	1	0.27838	1	0.40311	1	0.10512	1	0.58645	1	0.04932	1	0.58798	1
JMJD4	3 (5%)	59	1	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
HSD17B1	4 (6%)	58	0.91377	1	0.04788	1	0.76491	1	0.50815	1	0.91001	1	0.0081999	1	1	1	0.84273	1	0.54947	1	0.79586	1
COQ2	5 (8%)	57	0.36116	1	0.76786	1	NA	NA	NA	NA	0.43777	1	0.59874	1	1	1	0.67279	1	0.54696	1	0.61677	1
FEZ2	3 (5%)	59	0.46658	1	0.35411	1	NA	NA	NA	NA	0.22192	1	0.81447	1	0.19596	1	0.79493	1	0.7758	1	0.55609	1
DLEU7	3 (5%)	59	0.52815	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
RNF135	3 (5%)	59	0.75559	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
SPIRE2	3 (5%)	59	0.29998	1	0.03857	1	NA	NA	NA	NA	1	1	0.81424	1	1	1	0.79548	1	1	1	1	1
KRTAP5-5	3 (5%)	59	1	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
SGK223	3 (5%)	59	0.75448	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
C9ORF66	5 (8%)	57	1	1	0.92481	1	NA	NA	NA	NA	1	1	0.51207	1	0.58053	1	0.93592	1	0.34953	1	0.54101	1
AQP7	3 (5%)	59	0.75505	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
ADAMTS7	4 (6%)	58	0.19715	1	0.47667	1	0.01241	1	0.34993	1	0.090549	1	0.43811	1	0.082369	1	0.25824	1	0.12362	1	0.0387	1
PCDHB13	5 (8%)	57	0.395	1	0.14136	1	NA	NA	NA	NA	0.12746	1	0.35599	1	0.66312	1	0.059649	1	0.43606	1	0.45301	1
CSGALNACT2	3 (5%)	59	0.16142	1	0.0388	1	NA	NA	NA	NA	0.77419	1	0.81233	1	0.58303	1	0.87595	1	0.35154	1	0.40086	1
HLA-A	3 (5%)	59	1	1	1	1	NA	NA	NA	NA	0.85242	1	0.19409	1	1	1	0.50575	1	0.77538	1	0.25366	1
MTFMT	3 (5%)	59	1	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
NLRP5	4 (6%)	58	0.91419	1	0.17058	1	NA	NA	NA	NA	1	1	0.12119	1	0.77823	1	0.64252	1	1	1	0.076049	1
KCNJ11	4 (6%)	58	0.01914	1	0.70919	1	NA	NA	NA	NA	0.43636	1	0.2297	1	0.12555	1	0.053419	1	0.29139	1	0.25926	1
