rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(1), ALPP(1), ALPPL2(8), FPGS(14), SPR(1)	921600	25	23	7	2	0	9	3	13	0	0	0.0413	1.37e-13	8.45e-11
2	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(1), PRDX1(1), PRDX2(2), TPO(22)	1336570	26	25	7	2	3	0	21	0	2	0	0.0159	2.90e-09	8.93e-07
3	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(1), TPO(22)	1154920	23	22	4	2	2	0	21	0	0	0	0.0181	3.81e-08	7.82e-06
4	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF3(1), CDKN2A(2), MDM2(2), TP53(18)	1124314	23	18	23	2	2	0	7	1	12	1	0.105	3.25e-07	5.00e-05
5	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ATP6V0C(1), EPX(1), PRDX1(1), PRDX2(2), SHMT2(1), TPO(22)	1628686	28	27	9	3	4	0	22	0	2	0	0.0251	4.17e-07	5.13e-05
6	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(1), DAXX(4), PML(2), RARA(1), RB1(2), SIRT1(1), TNFRSF1A(1), TP53(18)	2553179	30	24	30	2	3	1	7	1	17	1	0.0464	6.15e-07	6.31e-05
7	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	NFKB1(1), TP53(18)	1391271	19	17	19	1	2	0	5	1	10	1	0.122	2.32e-06	0.000204
8	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(5), ATR(3), CHEK2(2), TP53(18)	2105624	28	24	28	4	3	0	6	3	15	1	0.479	2.99e-06	0.000221
9	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(1), ATM(5), MDM2(2), RB1(2), TIMP3(1), TP53(18)	2416850	29	23	29	3	2	0	6	1	19	1	0.214	3.22e-06	0.000221
10	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(1), GNAS(5), GNB1(2), PRKACA(1), PRKAR1A(7)	921215	16	15	15	2	1	0	3	2	10	0	0.512	4.70e-05	0.00270
11	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(5), RB1(2), TP53(18)	2370899	25	22	25	6	2	0	5	1	16	1	0.785	4.82e-05	0.00270
12	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(1), IDI1(5), SQLE(2)	449336	8	8	5	0	0	1	7	0	0	0	0.120	9.74e-05	0.00500
13	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	EPX(1), MTHFR(1), SHMT2(1), TPO(22)	1583527	25	24	6	4	4	0	21	0	0	0	0.0698	0.000111	0.00525
14	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	CDKN2A(2), MDM2(2), PIK3CA(1), PIK3R1(1), POLR1A(1), POLR1C(2), RB1(2), TBX2(1), TP53(18)	2722048	30	24	30	4	3	0	10	2	14	1	0.162	0.000137	0.00604
15	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	AOC3(1), EPX(1), GOT1(1), GOT2(2), MAOA(3), PRDX1(1), PRDX2(2), TPO(22)	3047226	33	30	14	4	6	0	23	0	4	0	0.0222	0.000170	0.00698
16	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	GALNS(1), GNS(2), HEXB(1), IDS(1), IDUA(14), LCT(1)	2002396	20	17	10	2	4	1	1	14	0	0	0.0861	0.000427	0.0160
17	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	APC(4), CD14(1), CTNNB1(14), DVL1(1), FZD1(6), GJA1(2), IRAK1(2), LBP(1), NFKB1(1), PIK3CA(1), PIK3R1(1), TLR4(3), WNT1(2)	4208091	39	29	28	3	0	1	14	11	13	0	0.0886	0.000443	0.0160
18	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(4), CTNNB1(14), DLL1(1), DVL1(1), FZD1(6), NOTCH1(4), WNT1(2)	3007948	32	25	21	4	1	1	9	7	14	0	0.393	0.000534	0.0174
19	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(1), IDI1(5), SQLE(2)	590510	8	8	5	0	0	1	7	0	0	0	0.123	0.000536	0.0174
20	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(2), ACTN2(2), BCAR1(1), CSK(1), CTNNA2(1), CTNNB1(14)	2698910	21	20	16	2	1	1	9	6	4	0	0.135	0.00244	0.0753
21	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(1), ATM(5), IGFBP3(1), MDM2(2), TP53(18)	2829201	27	20	27	8	3	0	6	2	15	1	0.814	0.00446	0.131
22	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ATM(5), CHEK2(2), MDM2(2), MRE11A(1), NFKB1(1), RAD50(3), RAD51(1), RBBP8(1), TP53(18), TP73(1)	3999822	35	25	35	5	3	0	10	3	18	1	0.341	0.00565	0.152
23	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(1), GNAS(5), GNB1(2), PRKAA2(1), PRKACB(1), PRKAG2(3), PRKAR1A(7)	2127011	20	17	19	3	2	1	4	2	11	0	0.461	0.00567	0.152
24	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	42	APAF1(1), BCL2L1(2), CASP8(1), FADD(2), GZMB(1), MAP3K1(2), MDM2(2), NFKB1(1), PARP1(3), TNFRSF1A(1), TP53(18)	5098871	34	25	34	4	6	1	11	1	14	1	0.0724	0.0161	0.398
25	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), HSD17B1(5), HSD17B4(3), HSD17B7(2)	1097614	11	9	7	2	6	0	3	1	1	0	0.260	0.0161	0.398
26	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(1), CFTR(2), GNAS(5), PRKACB(1), PRKAR1A(7), SLC9A3R1(1)	1809713	17	14	16	3	1	0	3	2	11	0	0.584	0.0182	0.432
27	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(1), CD3D(1), GZMB(1), HLA-A(4), ICAM1(1), ITGAL(1)	1191900	9	9	8	1	3	0	2	2	2	0	0.300	0.0219	0.489
28	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNAS(5), GNB1(2), PRKACB(1), PRKAR1A(7)	1362033	16	14	15	3	1	0	3	2	10	0	0.663	0.0222	0.489
29	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	APAF1(1), ATM(5), BCL2L1(2), TLN1(2), TP53(18)	3704416	28	22	28	6	4	0	6	1	16	1	0.610	0.0271	0.575
30	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2I(1), GTF2IRD1(1), STON1(1), TAF1(5), TAF1L(1), TAF4(1), TAF4B(1), TAF5(12), TAF7L(1), TBPL2(1)	4850336	25	21	14	1	2	0	8	13	2	0	0.0150	0.0293	0.602
31	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), FDFT1(1), HMGCR(1), IDI1(5), NQO2(1), SQLE(2)	1558700	11	10	8	1	0	1	8	0	2	0	0.212	0.0315	0.625
32	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(1), FDFT1(1), HMGCR(1), IDI1(5), NSDHL(1), SQLE(2)	1843221	11	11	8	1	0	1	8	1	1	0	0.236	0.0350	0.673
33	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(2), MAP2K3(2), NFATC1(1), PRKACB(1), PRKAR1A(7)	1658294	13	9	12	1	0	0	3	1	9	0	0.356	0.0506	0.945
34	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	HLA-DRB1(3)	328912	3	3	3	1	0	0	2	1	0	0	0.742	0.0612	1.000
35	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1B(1), GLI2(2), GLI3(9), PRKACB(1), PRKAR1A(7), SHH(2), SMO(3), SUFU(1)	2248824	26	19	19	5	11	1	6	0	8	0	0.152	0.0684	1.000
36	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	GRM1(3), PLCB1(3), PPP1CA(2), PRKACB(1), PRKAR1A(7)	2185883	16	12	15	3	1	0	2	2	11	0	0.602	0.0787	1.000
37	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCR3(1), HLA-DRB1(3), IL3(1)	407360	6	5	6	2	0	0	4	2	0	0	0.680	0.0826	1.000
38	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(1), ALOX12(1), ALOX5(3), CYP4F2(1), CYP4F3(1), EPX(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PRDX1(1), PRDX2(2), PTGDS(1), PTGS1(1), PTGS2(1), TPO(22)	3909168	43	34	24	8	4	1	29	3	6	0	0.0910	0.0879	1.000
39	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), ECHS1(2), EHHADH(1), HADHA(1), SDS(1)	665589	6	5	6	0	1	0	2	1	2	0	0.235	0.0887	1.000
40	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	GLUD1(1), PRODH(4)	808834	5	5	4	0	1	1	0	3	0	0	0.252	0.0900	1.000
41	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	GALNS(1), GNS(2), HEXB(1), IDS(1), IDUA(14), LCT(1)	2869029	20	17	10	3	4	1	1	14	0	0	0.184	0.0907	1.000
42	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	97560	1	1	1	0	0	0	0	0	1	0	0.717	0.0957	1.000
43	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CTH(1), GOT1(1), GOT2(2), LDHA(3)	910674	7	7	7	2	3	0	2	1	1	0	0.652	0.0987	1.000
44	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	EGFR(3), IGF1R(1), RB1(2), TEP1(2), TERT(1), TNKS(1), TP53(18)	3785860	28	21	28	6	5	1	7	1	13	1	0.388	0.102	1.000
45	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(1), GOT2(2)	356738	3	3	3	0	2	0	1	0	0	0	0.399	0.109	1.000
46	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	12	ADCY1(1), GNAS(5), PLCE1(2), PRKACB(1), PRKAR1A(7), RAP2B(1)	2071211	17	13	16	3	1	0	4	2	10	0	0.566	0.116	1.000
47	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(3), PAPSS2(1), SUOX(2)	815298	6	5	6	1	0	0	3	0	2	1	0.783	0.117	1.000
48	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(4), CREBBP(1), CTNNB1(14), DVL1(1), EP300(2), FZD1(6), HDAC1(1), LDB1(1), PITX2(3), TRRAP(1), WNT1(2)	4516441	36	27	26	5	3	0	12	7	14	0	0.341	0.118	1.000
49	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	PRKACB(1), PRKAR1A(7)	1746293	8	8	7	9	0	0	0	0	8	0	1.000	0.122	1.000
50	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(2), CHIA(2), CHIT1(3), CTBS(1), GNE(1), GNPDA1(1), HEXB(1), HK2(3), HK3(3), LHPP(2), MTMR1(1), MTMR2(1)	3943997	21	19	19	3	1	3	10	2	5	0	0.190	0.128	1.000
51	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(5), ATR(3), BRCA2(1), CHEK2(2), FANCF(1), MRE11A(1), RAD1(1), RAD17(1), RAD50(3), RAD51(1), RAD9A(1), TP53(18)	5893736	38	30	38	9	5	0	7	6	19	1	0.775	0.129	1.000
52	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(2), NDUFB5(2), NDUFB7(1), NDUFS2(1)	964591	7	6	7	0	1	0	4	0	2	0	0.215	0.131	1.000
53	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(2), MTMR1(1), MTMR2(1)	869921	4	4	3	1	0	3	0	0	1	0	0.705	0.143	1.000
54	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT3(3), FUT6(2)	707549	5	5	5	1	2	0	2	1	0	0	0.442	0.145	1.000
55	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(2), DPYD(2), DPYS(2), PANK2(15), PPCS(1)	1887197	22	20	9	5	1	0	17	2	2	0	0.451	0.151	1.000
56	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO2(1), ENO3(1), FARS2(1), GOT1(1), GOT2(2)	1118895	6	6	6	1	3	0	1	2	0	0	0.436	0.156	1.000
57	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ECHS1(2), HADH(1), HADHA(1), HADHB(1), HSD17B4(3), MECR(1)	1170442	9	7	9	0	0	0	5	2	2	0	0.138	0.162	1.000
58	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(1), FUCA1(4), FUCA2(1), HEXB(1), LCT(1), MANBA(2)	2305288	10	10	10	0	2	1	1	5	1	0	0.0845	0.166	1.000
59	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(2), TH(3)	826124	5	5	5	1	2	0	2	0	1	0	0.407	0.202	1.000
60	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	AOC3(1), EPX(1), ESCO2(1), GOT1(1), GOT2(2), MAOA(3), MIF(3), PNPLA3(2), TPO(22)	4637962	36	31	16	6	5	0	27	2	2	0	0.0794	0.202	1.000
61	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH6(1), ADH7(2), AOC3(1), DBH(2), DCT(1), GOT1(1), GOT2(2), HGD(1), MAOA(3), TH(3), TPO(22)	4370623	39	31	20	8	7	0	27	1	4	0	0.110	0.209	1.000
62	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(1), APC(4), BMPR1A(2), BMPR2(1), CHRD(2), CTNNB1(14), DVL1(1), FZD1(6), GATA4(1), MEF2C(2), NKX2-5(1), NOG(1), RFC1(1), TGFBR2(2), TGFBR3(4), WNT1(2)	4999122	45	28	35	9	2	1	15	11	16	0	0.605	0.216	1.000
63	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(1), FUCA1(4), FUCA2(1), GALNS(1), GNS(2), HEXB(1), IDS(1), IDUA(14), LCT(1), MAN2B1(1), MANBA(2)	4871048	29	22	19	4	5	3	1	19	1	0	0.113	0.230	1.000
64	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(1), EP300(2), PRKACB(1), PRKAR1A(7), RARA(1)	2810551	12	11	11	4	0	0	2	0	10	0	0.954	0.234	1.000
65	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ECHS1(2), EHHADH(1), HADHA(1), SDHB(1), SDS(1)	1058757	6	5	6	1	1	0	2	1	2	0	0.553	0.269	1.000
66	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(1), CCR3(1), HLA-DRB1(3)	726816	5	4	5	2	0	0	3	2	0	0	0.778	0.274	1.000
67	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	BDKRB2(1), KNG1(1), NOS3(4)	1377399	6	6	6	1	2	1	2	1	0	0	0.356	0.277	1.000
68	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS2(1), CTH(1), GOT1(1), GOT2(2), LDHA(3), SDS(1)	1717418	9	9	9	2	4	0	2	2	1	0	0.459	0.279	1.000
69	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), ECHS1(2), EHHADH(1), HADH(1), HADHA(1), HSD17B4(3), NTAN1(1), SIRT1(1)	1628304	11	8	11	0	0	0	6	2	3	0	0.0870	0.283	1.000
70	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(1), FSHR(1), GNAS(5), XPO1(1)	1311265	8	7	8	1	2	0	2	2	2	0	0.463	0.285	1.000
71	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(1), FUCA1(4), FUCA2(1), HEXB(1), LCT(1), MAN2B1(1), MANBA(2)	2846697	11	10	11	1	2	2	1	5	1	0	0.228	0.310	1.000
72	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	GOT1(1), GOT2(2)	635908	3	3	3	0	2	0	1	0	0	0	0.386	0.329	1.000
73	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ECHS1(2), EHHADH(1), HADHA(1), HADHB(1), SDS(1)	1143871	6	5	6	0	1	0	2	1	2	0	0.248	0.331	1.000
74	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1)	158301	1	1	1	0	0	0	1	0	0	0	0.783	0.336	1.000
75	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(2), BCAT2(1), DPYD(2), DPYS(2), PANK2(15), PPCS(1), VNN1(1)	2359280	24	21	11	6	1	0	19	2	2	0	0.477	0.346	1.000
76	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	8	GABRA1(2), GABRA2(2), GABRA6(2), GPX1(1)	887334	7	6	7	2	0	0	6	1	0	0	0.678	0.351	1.000
77	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(1), GSS(1), NFKB1(1), NOX1(1), XDH(3)	1387484	7	6	7	0	0	0	5	1	1	0	0.190	0.352	1.000
78	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	HLA-DRB1(3), IL2(1)	544598	4	4	4	2	0	0	3	1	0	0	0.833	0.356	1.000
79	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), RB1(2)	888811	3	3	3	1	0	0	1	0	2	0	0.824	0.370	1.000
80	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT2(1), B3GALT5(1), FUT3(3)	988565	5	5	5	0	2	0	2	1	0	0	0.210	0.370	1.000
81	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1)	221925	1	1	1	0	0	0	1	0	0	0	0.772	0.371	1.000
82	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	GNE(1), GNPDA1(1), HEXB(1), HK2(3), HK3(3)	2332008	9	9	9	1	1	0	6	1	1	0	0.256	0.384	1.000
83	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1)	228975	1	1	1	0	1	0	0	0	0	0	0.652	0.387	1.000
84	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(5), BMPR1B(1), CCND2(1), CEBPB(1), EGR1(2), FSHR(1), GJA4(1), MLH1(2), NCOR1(1), NR5A1(2), NRIP1(3), PGR(1), VDR(1)	4689063	22	16	22	3	2	2	8	1	9	0	0.296	0.396	1.000
85	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP5(1), ACP6(1), ACPP(1), FLAD1(1), LHPP(2), MTMR1(1), MTMR2(1)	2072410	8	8	7	2	0	3	2	2	1	0	0.611	0.399	1.000
86	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(1), CTH(1), MUT(1)	675049	3	3	3	0	0	0	2	0	1	0	0.608	0.400	1.000
87	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	FADS2(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1)	1460378	8	7	8	0	1	0	3	1	3	0	0.169	0.401	1.000
88	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLUD1(1), GLUD2(1)	610547	2	2	2	0	1	0	0	1	0	0	0.570	0.411	1.000
89	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(7), NDUFA12(1), NDUFB11(2)	575162	10	8	5	3	0	0	10	0	0	0	0.683	0.422	1.000
90	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(1)	202484	1	1	1	0	0	0	0	0	1	0	1.000	0.423	1.000
91	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(1), BMPR1A(2), BMPR1B(1), BMPR2(1)	845749	5	4	5	0	1	1	2	1	0	0	0.278	0.427	1.000
92	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ASPH(1), EP300(2), EPO(1), LDHA(3), NOS3(4), P4HB(1)	2302595	12	11	12	2	1	1	5	3	2	0	0.365	0.434	1.000
93	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	APAF1(1), DAXX(4)	1510615	5	5	5	1	0	1	0	0	4	0	0.715	0.434	1.000
94	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	EGR2(1), EGR3(1), MAP3K1(2), NFATC1(1), NFKB1(1), PLCG1(3), PPP3CB(1), PRKACB(1), PRKAR1A(7), VIP(1), VIPR2(1)	3785138	20	16	19	4	3	0	7	2	8	0	0.406	0.440	1.000
95	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	9	AKAP9(3), MAP2(2), PPP1CA(2), PRKACB(1)	2262487	8	8	8	1	0	0	3	1	4	0	0.649	0.442	1.000
96	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	HK2(3), HK3(3)	1432669	6	6	6	1	0	0	4	1	1	0	0.461	0.446	1.000
97	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ECHS1(2), HADHA(1)	739035	3	3	3	0	0	0	1	0	2	0	0.644	0.463	1.000
98	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	23	APC(4), CREBBP(1), CTNNB1(14), DVL1(1), FZD1(6), HDAC1(1), WIF1(1), WNT1(2)	4133071	30	26	20	6	0	0	10	7	13	0	0.753	0.466	1.000
99	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(1), CASP8(1), DFFA(1), GZMB(1), SCAP(4), SREBF2(2)	2577152	10	9	10	1	3	0	1	0	6	0	0.457	0.475	1.000
100	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(2), LEPR(2), PRKAA2(1), PRKAG2(3)	1943567	8	7	8	1	2	1	3	0	2	0	0.400	0.484	1.000
101	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	GRIA2(3)	521591	3	2	3	0	0	0	1	0	2	0	0.437	0.495	1.000
102	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	NDUFA1(1), SDHA(1), SDHB(1), SDHD(1)	882443	4	3	4	1	0	0	2	2	0	0	0.697	0.503	1.000
103	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCND2(1), CDKN2A(2), RB1(2), RBL1(1), TFDP1(1)	2148074	7	7	7	1	3	0	1	0	3	0	0.377	0.520	1.000
104	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(1), EIF2AK4(2), EIF2B5(1), PPP1CA(2)	1548603	6	5	6	0	0	0	1	1	4	0	0.621	0.524	1.000
105	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	CMA1(1), CPA3(1), CTSA(2), ENPEP(3), LNPEP(1), MME(3), NLN(3)	2873519	14	12	14	3	1	2	9	1	0	1	0.374	0.541	1.000
106	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(1), CD3D(1), CREBBP(1), CSK(1), GNAS(5), GNB1(2), HLA-DRB1(3), LCK(1), PRKACB(1), PRKAR1A(7), ZAP70(1)	3182524	24	18	23	6	1	0	9	3	11	0	0.655	0.569	1.000
107	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(1), CD3D(1), CREBBP(1), CSK(1), GNAS(5), GNB1(2), HLA-DRB1(3), LCK(1), PRKACB(1), PRKAR1A(7), ZAP70(1)	3182524	24	18	23	6	1	0	9	3	11	0	0.655	0.569	1.000
108	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(1), BCL2L1(2), CSF2RB(1), IGF1R(1), IL3(1), PIK3CA(1), PIK3R1(1), PRKACB(1), PRKAR1A(7)	2987110	16	14	15	4	2	0	3	2	9	0	0.707	0.593	1.000
109	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C9(1)	271437	1	1	1	1	0	0	1	0	0	0	0.947	0.595	1.000
110	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	CKM(2), LDHA(3)	1244675	5	5	5	1	1	0	2	2	0	0	0.563	0.604	1.000
111	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASDHPPT(1), KARS(1)	626882	2	2	2	1	1	0	1	0	0	0	0.863	0.614	1.000
112	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	LDLR(1), MBTPS1(2), SCAP(4), SREBF2(2)	1729468	9	6	9	1	3	0	2	0	4	0	0.424	0.617	1.000
113	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	PIK3CA(1), PIK3R1(1), PLCB1(3), PLCG1(3), VAV1(3)	1764475	11	9	11	3	5	0	3	2	1	0	0.597	0.619	1.000
114	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(2), CREBBP(1), DFFA(1), GZMB(1)	1453793	5	5	5	1	2	0	2	1	0	0	0.507	0.619	1.000
115	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD3D(1), CD8A(1), IL3(1)	846177	3	3	3	0	0	1	2	0	0	0	0.400	0.627	1.000
116	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(2), MMP9(1), RECK(1), TIMP3(1)	1049960	5	4	5	2	2	0	1	0	2	0	0.843	0.633	1.000
117	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR2(1), GPR171(1), GPR34(1), GPR39(2), GPR68(1), GPR75(1)	1341959	7	6	7	2	1	0	5	1	0	0	0.511	0.634	1.000
118	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	CPS1(3), GLUD1(1), GOT1(1)	1058236	5	4	5	2	1	0	2	1	1	0	0.802	0.634	1.000
119	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(3)	1053317	3	3	3	0	0	0	1	2	0	0	0.475	0.647	1.000
120	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(1), B3GALNT1(1), B3GALT5(1), GBGT1(2), HEXB(1), ST3GAL1(1)	1453288	7	6	7	1	2	0	3	1	1	0	0.397	0.649	1.000
121	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), CASP8(1), FADD(2), TNFRSF1A(1)	1142801	5	5	5	2	1	1	1	0	2	0	0.876	0.665	1.000
122	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(2), IARS(1), LARS(1), LARS2(1), PDHB(1)	1347228	6	6	6	2	0	0	2	3	1	0	0.829	0.675	1.000
123	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(1), SNCAIP(1)	855228	2	2	2	1	0	0	2	0	0	0	0.877	0.678	1.000
124	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(1)	511888	1	1	1	1	0	0	0	0	1	0	1.000	0.682	1.000
125	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	RB1(2), TFDP1(1)	1149866	3	3	3	1	1	0	0	0	2	0	0.693	0.684	1.000
126	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	RB1(2), TFDP1(1)	1168917	3	3	3	1	1	0	0	0	2	0	0.685	0.691	1.000
127	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(1), ABCB11(1), ABCB4(2), ABCC1(1), ABCC3(2), GSTP1(1)	1977073	8	8	8	2	3	1	2	2	0	0	0.452	0.692	1.000
128	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT5(2), ST3GAL1(1)	1060998	3	3	3	0	1	0	0	2	0	0	0.493	0.692	1.000
129	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(5)	1864143	5	5	5	5	0	0	1	0	4	0	0.999	0.695	1.000
130	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(1)	426720	1	1	1	0	0	0	1	0	0	0	0.759	0.695	1.000
131	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	DFFA(1), GZMB(1), TOP2A(1)	1390656	3	3	3	1	2	0	1	0	0	0	0.782	0.697	1.000
132	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD3D(1)	442188	1	1	1	0	0	0	1	0	0	0	0.745	0.707	1.000
133	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	HGD(1)	305249	1	1	1	0	0	0	1	0	0	0	0.764	0.714	1.000
134	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(1)	768001	2	2	2	0	1	0	0	1	0	0	0.564	0.714	1.000
135	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPS(1), CHPT1(2), ENPP2(2), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLD2(1), PPAP2C(1)	3235717	14	10	14	1	2	0	8	2	2	0	0.102	0.723	1.000
136	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(1), FARSB(1), GOT1(1), GOT2(2)	1189492	5	5	5	2	2	0	1	1	1	0	0.816	0.731	1.000
137	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1)	526215	1	1	1	1	0	0	1	0	0	0	0.928	0.731	1.000
138	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(3), CHST11(1), CHST13(3), PAPSS2(1), SUOX(2)	1238650	10	8	9	4	0	0	4	3	2	1	0.886	0.735	1.000
139	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(1), BCL2L1(2), BCL2L11(1)	1552395	4	4	4	1	1	0	0	0	3	0	0.694	0.739	1.000
140	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	37	G6PD(2), GPX1(1), GPX7(1), GSS(1), GSTA2(1), GSTK1(1), GSTO2(1), GSTP1(1), GSTT2(2), MGST1(1), OPLAH(3)	3142966	15	12	14	3	4	1	4	1	5	0	0.480	0.739	1.000
141	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(1), CHAT(1), DBH(2), MAOA(3), SLC18A3(1), TH(3)	1999566	11	9	11	3	2	1	5	0	3	0	0.529	0.752	1.000
142	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(1), BCL2L1(2), CASP8(1), DFFA(1)	1830578	5	5	5	1	2	0	0	0	3	0	0.686	0.763	1.000
143	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), HEXB(1), LCT(1), ST3GAL1(1), ST6GALNAC3(1), ST6GALNAC5(1)	2221670	6	6	6	1	2	0	2	1	1	0	0.487	0.763	1.000
144	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH6(1), ADH7(2)	756040	3	3	3	5	1	0	0	1	1	0	0.999	0.765	1.000
145	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CSAD(1)	803225	2	2	2	0	0	0	2	0	0	0	0.558	0.765	1.000
146	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	OXCT1(1)	459287	1	1	1	0	0	0	0	1	0	0	0.737	0.766	1.000
147	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(1), GBGT1(2), HEXB(1), ST3GAL1(1)	1373769	5	4	5	1	1	0	2	1	1	0	0.618	0.769	1.000
148	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	RB1(2), TFDP1(1)	1138640	3	3	3	2	1	0	0	0	2	0	0.889	0.769	1.000
149	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(2), EGFR(3), TF(1)	1724137	6	6	6	2	2	0	2	2	0	0	0.701	0.778	1.000
150	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP5(1), ACPP(1), FLAD1(1)	1333133	3	3	3	1	0	0	2	1	0	0	0.762	0.782	1.000
151	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	EGR1(2), MAPK1(1), NGFR(2)	1149786	5	5	5	1	3	0	1	1	0	0	0.386	0.786	1.000
152	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDHPPT(1), KARS(1)	919051	2	2	2	1	1	0	1	0	0	0	0.858	0.790	1.000
153	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	GRIN1(1), GRIN2B(2), GRIN2C(2), GRIN2D(1), NOS1(2), PPP3CB(1), PRKACB(1), PRKAR1A(7)	3563730	17	14	16	9	4	0	4	1	8	0	0.965	0.790	1.000
154	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ALDH6A1(1), BCAT1(2), BCAT2(1), ECHS1(2), EHHADH(1), HADH(1), HADHA(1), HADHB(1), HMGCS2(1), HSD17B4(3), MCCC1(2), MUT(1), OXCT1(1), PCCA(1)	5937275	19	16	19	0	0	0	10	6	3	0	0.0118	0.796	1.000
155	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(1), SHMT2(1)	599187	2	2	2	0	1	0	1	0	0	0	0.481	0.799	1.000
156	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	PTGS1(1), PTGS2(1)	716546	2	2	2	2	0	0	1	0	1	0	0.980	0.802	1.000
157	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ALDH6A1(1), BCAT1(2), ECHS1(2), EHHADH(1), HADHA(1), HADHB(1), MCCC1(2), MUT(1), OXCT1(1), PCCA(1), SDS(1)	4918177	14	13	14	1	1	0	5	5	3	0	0.124	0.802	1.000
158	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(1), CYP11B1(1), CYP11B2(1), CYP17A1(1), CYP21A2(1), HSD11B1(1)	1324127	7	7	7	8	1	0	4	0	2	0	0.997	0.804	1.000
159	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(1), CYP11B1(1), CYP11B2(1), CYP17A1(1), CYP21A2(1), HSD11B1(1)	1324127	7	7	7	8	1	0	4	0	2	0	0.997	0.804	1.000
160	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	SHH(2), XPO1(1)	1175229	3	3	3	1	1	0	2	0	0	0	0.725	0.804	1.000
161	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG3(1), BECN1(1), GABARAPL1(1), IFNA8(1), PIK3C3(1), PRKAA2(1), ULK1(1), ULK2(1), ULK3(1)	2897090	9	8	9	1	0	0	4	1	4	0	0.527	0.813	1.000
162	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	GOT1(1), GOT2(2), GPT2(2), MDH2(1), PGK2(3), RPIA(1), TKTL2(3)	2762154	13	9	12	4	3	2	5	1	2	0	0.590	0.821	1.000
163	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	F13A1(1), PLAT(1), PLG(1), SERPINB2(1), SERPINE1(1)	1824174	5	4	5	1	1	1	1	1	1	0	0.562	0.822	1.000
164	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SRP72(3)	1015653	3	3	3	0	1	0	2	0	0	0	0.464	0.827	1.000
165	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	RAB6A(1)	585537	1	1	1	0	0	0	0	1	0	0	0.794	0.827	1.000
166	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	KEAP1(2), MAPK1(1)	1256548	3	3	3	1	1	0	1	1	0	0	0.686	0.827	1.000
167	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD3D(1), CTLA4(2), HLA-DRB1(3), IL2(1), ITK(1), LCK(1), PIK3CA(1), PIK3R1(1), PTPN11(1)	1734581	12	12	12	4	0	0	6	5	1	0	0.757	0.831	1.000
168	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(2)	491541	2	1	2	1	0	0	2	0	0	0	0.813	0.833	1.000
169	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V0A1(2), ATP6V0A4(1), ATP6V0C(1), ATP6V1A(1), FDXR(2)	2185409	7	7	7	2	1	0	4	2	0	0	0.603	0.837	1.000
170	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ECHS1(2), EHHADH(1), HADHA(1), SDS(1)	1664821	5	4	5	0	1	0	2	0	2	0	0.284	0.845	1.000
171	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	IL3(1), ITGAX(1), TLR2(2), TLR4(3), TLR7(1), TLR9(2)	2528489	10	8	10	2	0	0	8	1	1	0	0.399	0.850	1.000
172	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNB1(2), HTR2C(1), PLCB1(3), TUB(1)	966641	7	7	7	3	2	0	4	1	0	0	0.759	0.851	1.000
173	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACSL1(3), ACSL3(2), EHHADH(1), HADHA(1)	2279180	7	6	7	2	1	1	3	0	2	0	0.686	0.852	1.000
174	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	FUT3(3), FUT4(1), FUT6(2), GCNT2(1)	2185668	7	7	7	2	3	0	2	2	0	0	0.575	0.853	1.000
175	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	UGP2(1), UGT1A3(1), UGT1A5(2), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B15(2), UGT2B28(1)	3646659	14	10	13	2	1	0	11	2	0	0	0.268	0.855	1.000
176	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT10(1), GALNT3(2), GALNT4(1), GALNT8(2), ST3GAL1(1)	2009424	7	5	7	1	0	0	2	2	3	0	0.593	0.860	1.000
177	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(2)	1063189	2	2	2	1	0	0	1	1	0	0	0.863	0.861	1.000
178	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(1), MTFMT(4), MTHFD1(1), MTHFD1L(1), MTHFR(1), MTR(1), SHMT2(1)	2619899	10	10	8	3	2	0	1	7	0	0	0.585	0.861	1.000
179	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	CASP8(1), FADD(2), MAP3K1(2), MAPK1(1), NFKB1(1), NSMAF(3), TNFRSF1A(1)	2776255	11	11	9	3	2	1	3	4	1	0	0.630	0.862	1.000
180	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(2), AOC3(1), CHDH(6), CHKB(1), CTH(1), DAO(1), GARS(35), GCAT(2), MAOA(3), PEMT(1), PIPOX(1), SARDH(1), SDS(1), SHMT2(1)	5995146	57	47	19	13	5	1	37	10	4	0	0.166	0.864	1.000
181	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(1), CASP8(1), GZMB(1)	1721575	3	3	3	1	1	0	0	0	2	0	0.822	0.867	1.000
182	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	ADSS(1), AGXT(2), CAD(1), DDO(1), GOT1(1), GOT2(2), GPT2(2), PC(1)	3608683	11	10	10	2	3	2	2	2	2	0	0.392	0.868	1.000
183	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	CAPN2(3), CAPNS1(1), CXCR3(2), EGFR(3), MAPK1(1), MYLK(2), PRKACB(1), PRKAR1A(7), TLN1(2)	4583036	22	18	21	9	5	0	6	2	9	0	0.864	0.869	1.000
184	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ANXA1(1), GNAS(5), GNB1(2), NFKB1(1), NOS3(4), PIK3CA(1), PIK3R1(1)	2522425	15	13	15	4	2	1	7	3	2	0	0.629	0.869	1.000
185	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B4GALT7(1), HS3ST2(3), HS3ST3A1(2), XYLT1(1)	936848	7	4	7	3	2	1	4	0	0	0	0.681	0.872	1.000
186	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B4GALT7(1), HS3ST2(3), HS3ST3A1(2), XYLT1(1)	936848	7	4	7	3	2	1	4	0	0	0	0.681	0.872	1.000
187	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	UGP2(1)	683415	1	1	1	0	0	0	1	0	0	0	0.780	0.874	1.000
188	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CYP11B2(1), CYP17A1(1), HSD11B1(1)	943234	3	3	3	3	0	0	2	0	1	0	0.980	0.877	1.000
189	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	PFKL(2), PGAM1(1)	1259150	3	3	3	1	1	1	0	1	0	0	0.699	0.878	1.000
190	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	HMGCS2(1), OXCT1(1)	1013102	2	2	2	0	0	0	1	1	0	0	0.599	0.884	1.000
191	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	22	FADD(2), IRAK1(2), MAP3K1(2), NFKB1(1), TLR4(3), TNFRSF1A(1)	3374559	11	10	10	3	2	1	6	2	0	0	0.563	0.888	1.000
192	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(1), ALPP(1), ALPPL2(8), ASCC3(1), ATP13A2(1), DDX18(2), DDX4(2), DDX50(2), EP400(4), ERCC2(19), ERCC3(1), FPGS(14), MOV10L1(1), PTS(1), RAD54B(1), RUVBL2(1), SETX(2), SMARCA2(4), SMARCA5(1), SPR(1)	8571596	68	44	31	13	21	10	10	18	9	0	0.0730	0.889	1.000
193	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(1), AFMID(1), CS(1), GRHPR(1), HAO1(1), MDH2(1), MTHFD1(1), MTHFD1L(1)	1823536	8	6	8	2	1	0	5	2	0	0	0.568	0.889	1.000
194	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(1), PLCB1(3)	1137637	4	3	4	2	1	0	2	1	0	0	0.799	0.893	1.000
195	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	G6PD(2), GPX1(1), GSS(1), GSTA2(1), GSTO2(1), GSTP1(1), GSTT2(2), MGST1(1)	2559485	10	10	10	3	2	1	2	1	4	0	0.793	0.894	1.000
196	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(1), CHAT(1), PEMT(1), SLC18A3(1)	955793	4	2	4	2	0	1	2	1	0	0	0.845	0.900	1.000
197	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	13	DUSP1(1), IKBKAP(2), MAP3K1(2), NFKB1(1)	2544408	6	6	6	0	1	0	4	0	1	0	0.201	0.901	1.000
198	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(1), HLA-A(4), LAT(1), PIK3CA(1), PIK3R1(1), PTPN6(1), SYK(1), VAV1(3)	2591379	13	10	12	3	3	0	2	3	5	0	0.671	0.901	1.000
199	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	GCNT2(1)	860306	1	1	1	1	1	0	0	0	0	0	0.940	0.903	1.000
200	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	MAP2K3(2), MAP3K1(2), MAPK1(1), NFKB1(1), PIK3CA(1), PIK3R1(1), RB1(2)	2670656	10	9	10	3	1	0	4	3	2	0	0.673	0.906	1.000
201	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	THBS1(1)	969294	1	1	1	0	0	0	0	1	0	0	0.808	0.906	1.000
202	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGFR(3), ERBB3(1)	1392874	4	4	4	2	2	0	2	0	0	0	0.837	0.907	1.000
203	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1), CS(1), GRHPR(1), HAO1(1), MDH2(1), MTHFD1(1), MTHFD1L(1)	1738418	7	6	7	2	1	0	4	2	0	0	0.639	0.907	1.000
204	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(1), FH(1), MDH2(1), SDHB(1)	1213540	4	3	4	2	0	0	3	1	0	0	0.871	0.919	1.000
205	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	UGT1A3(1), UGT1A5(2), UGT2B15(2)	2347962	5	5	5	0	1	0	2	2	0	0	0.254	0.922	1.000
206	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(1), GNAS(5), GNB1(2), NFATC1(1), PLCG1(3), PPP3CB(1), PRKACB(1), PRKAR1A(7)	4784170	21	17	20	6	3	0	6	2	10	0	0.728	0.925	1.000
207	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(2), POLD2(1), POLE(3), POLG(1), POLQ(1)	2308300	8	7	7	2	1	1	3	2	1	0	0.645	0.925	1.000
208	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	18	DUSP1(1), IKBKAP(2), MAP3K1(2), NFKB1(1), TANK(1)	3129307	7	7	7	1	1	0	5	0	1	0	0.389	0.927	1.000
209	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	JAK1(1), JAK2(2)	1102806	3	2	3	2	0	0	1	2	0	0	0.921	0.929	1.000
210	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CDKN2A(2)	1219123	2	2	2	1	0	0	1	0	1	0	0.922	0.930	1.000
211	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(5), NRG2(2), NRG3(2)	1228071	9	6	8	4	2	0	5	2	0	0	0.794	0.932	1.000
212	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMB1(2), PSMB3(1), PSMB5(1), PSMC2(2), PSMD6(1)	2174857	7	4	7	1	1	0	3	2	1	0	0.509	0.933	1.000
213	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	LRP8(1), RELN(7)	1894701	8	7	8	3	0	0	5	3	0	0	0.755	0.935	1.000
214	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ARPC2(1)	1121521	1	1	1	3	0	0	0	0	1	0	1.000	0.937	1.000
215	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CTH(1), MARS(1), MARS2(1), PAPSS2(1), SCLY(1)	1717294	5	4	5	5	1	0	1	1	2	0	0.995	0.938	1.000
216	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	GAB1(1), MAP3K1(2), MAP3K12(1), MAP3K13(1), MAP3K3(1), MAP3K4(1), MAPK7(2), MYEF2(1), NR2C2(1), PAPPA(5), TP53(18)	6861642	34	22	33	9	5	1	14	2	11	1	0.598	0.939	1.000
217	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CHPT1(2), LCMT1(1), PCYT1B(1), WBSCR22(1)	1926195	5	5	5	2	0	1	3	1	0	0	0.723	0.943	1.000
218	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	CEBPB(1), CLDN5(3), CRY2(1), GFRA1(2), GSTP1(1), HSPA8(1), IDI1(5), KLF9(1), NCKAP1(1), NCOA4(2), PER1(1), UGP2(1), VAPA(1), ZFR(1)	5039485	22	17	19	4	3	2	12	4	1	0	0.258	0.943	1.000
219	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(2), GATA1(1)	1125562	3	3	3	2	1	0	1	1	0	0	0.899	0.946	1.000
220	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	HDAC9(2), MEF2C(2)	1169349	4	3	4	2	1	0	1	1	1	0	0.885	0.947	1.000
221	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC3(1)	809070	1	1	1	1	1	0	0	0	0	0	0.908	0.948	1.000
222	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOSL2(1), IFNAR2(1), NFKB1(1), TNFRSF11A(1), TNFSF11(1)	1505771	5	5	5	2	1	0	4	0	0	0	0.757	0.950	1.000
223	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ACACA(2), ACACB(4), ACSS2(1), ALDH6A1(1), ECHS1(2), EHHADH(1), HADHA(1), LDHA(3), MUT(1), PCCA(1)	5365060	17	13	17	3	2	0	10	2	3	0	0.347	0.951	1.000
224	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(2), ATP6V0A4(1), ATP6V0C(1), ATP6V1A(1)	2056943	5	5	5	2	1	0	3	1	0	0	0.741	0.951	1.000
225	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(2), ATP6V0A4(1), ATP6V0C(1), ATP6V1A(1)	2056943	5	5	5	2	1	0	3	1	0	0	0.741	0.951	1.000
226	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(2), ATP6V0A4(1), ATP6V0C(1), ATP6V1A(1)	2056943	5	5	5	2	1	0	3	1	0	0	0.741	0.951	1.000
227	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	SHMT2(1)	793973	1	1	1	0	1	0	0	0	0	0	0.673	0.951	1.000
228	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(2), BLVRA(1), CP(1), EPRS(3), UGT1A3(1), UGT1A5(2), UGT2B15(2)	3686394	12	9	12	3	2	0	4	5	1	0	0.511	0.952	1.000
229	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3D(1), IL2(1), TGFBR2(2), TGFBR3(4), TOB2(1)	1462586	9	7	9	6	1	0	5	1	2	0	0.975	0.952	1.000
230	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(1), ABCC2(2), BCHE(2), UGT1A3(1), UGT1A5(2)	3074663	8	7	8	0	1	0	5	2	0	0	0.104	0.955	1.000
231	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	MAPK1(1), NFKB1(1), PLCB1(3)	2099992	5	4	5	1	1	0	2	2	0	0	0.511	0.955	1.000
232	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	MAPK1(1), NFKB1(1), PIK3CA(1), PIK3R1(1), RB1(2), TFDP1(1)	2757893	7	7	7	2	1	0	2	2	2	0	0.637	0.956	1.000
233	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMB1(2), PSMB3(1), PSMB5(1), PSMB9(1)	1199407	5	2	5	1	1	0	4	0	0	0	0.577	0.956	1.000
234	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(2), GABBR1(2), GPRC5B(1), GPRC5D(1), GRM1(3), GRM3(3), GRM4(1), GRM5(1), GRM8(4)	2844263	18	7	18	3	1	0	12	3	2	0	0.150	0.959	1.000
235	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	EPRS(3), FARS2(1), GARS(35), IARS(1), KARS(1), LARS(1), LARS2(1), MARS(1), MARS2(1), QARS(1), WARS2(1)	4302753	47	40	15	10	3	1	35	6	2	0	0.258	0.960	1.000
236	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ALDH5A1(1), CAD(1), CPS1(3), EPRS(3), GLUD1(1), GMPS(1), GOT1(1), GOT2(2), GPT2(2), GSS(1), NADSYN1(2), QARS(1)	4541645	19	13	19	4	2	3	5	4	5	0	0.451	0.963	1.000
237	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	16	CREBBP(1), EP300(2), FADD(2), NFKB1(1), TNFRSF1A(1)	3073962	7	7	7	2	1	1	4	0	1	0	0.704	0.965	1.000
238	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	WDR1(2)	1502161	2	2	2	2	0	0	0	1	1	0	0.981	0.967	1.000
239	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR2B(2), POLR2H(1), POLRMT(5)	1849011	8	8	5	3	1	4	2	0	1	0	0.766	0.969	1.000
240	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(3), PRKACB(1)	1370134	4	3	4	2	0	0	2	0	2	0	0.930	0.970	1.000
241	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(1), ESR1(1), TUBA8(2)	1540273	4	4	4	2	2	0	1	1	0	0	0.753	0.970	1.000
242	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(1), JAK1(1), JAK2(2), TYK2(2)	1440563	7	6	7	3	0	1	2	2	2	0	0.846	0.971	1.000
243	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(1), JAK1(1), JAK2(2), TYK2(2)	1440563	7	6	7	3	0	1	2	2	2	0	0.846	0.971	1.000
244	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	32	CD14(1), IRAK1(2), MAP2K3(2), MAP3K1(2), NFKB1(1), PPARA(1), TLR2(2), TLR4(3), TLR6(1), TLR7(1), TLR9(2)	5022047	18	15	17	4	1	1	9	5	2	0	0.485	0.973	1.000
245	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(1), JAK2(2), JAK3(3), MAPK1(1), TYK2(2)	1660174	9	6	9	3	1	0	2	4	2	0	0.746	0.973	1.000
246	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR2(1), JAK1(1), TYK2(2)	1482978	4	4	4	2	1	0	1	0	2	0	0.848	0.974	1.000
247	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD3D(1), CD8A(1), ICAM1(1), ITGAL(1)	1447271	4	4	4	2	1	1	2	0	0	0	0.782	0.975	1.000
248	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CRY2(1), PER1(1)	1181670	2	2	2	0	1	0	1	0	0	0	0.563	0.976	1.000
249	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	HK2(3), HK3(3)	1643856	6	6	6	3	0	0	4	1	1	0	0.852	0.977	1.000
250	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(1), PGAP1(1), PIGG(2), PIGO(1), PIGU(2), PIGZ(1)	3399862	9	5	9	2	0	1	4	1	3	0	0.559	0.977	1.000
251	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	31	APC(4), CTNNB1(14), DACT1(2), DKK1(1), DKK2(1), DVL1(1), LRP1(6), NKD1(1), NKD2(1), PIN1(1), PTPRA(1), WIF1(1)	5638790	34	25	29	8	6	0	12	10	6	0	0.476	0.977	1.000
252	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C6(1), C7(1), C9(3)	1728980	5	5	5	3	0	0	3	1	1	0	0.900	0.977	1.000
253	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(1), JAK1(1)	1655844	2	2	2	1	1	0	1	0	0	0	0.781	0.977	1.000
254	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	CAPNS1(1)	1332097	1	1	1	2	0	0	0	0	1	0	0.974	0.977	1.000
255	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	JAK1(1), JAK2(2), PTPRU(1)	1558492	4	3	4	2	0	0	2	2	0	0	0.861	0.978	1.000
256	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	KHK(2), LCT(1), PYGL(1)	1889952	4	4	4	2	2	0	1	1	0	0	0.825	0.978	1.000
257	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	ICAM1(1), ITGA4(1), ITGAL(1), SELE(1)	1686558	4	4	4	3	1	0	1	1	0	1	0.943	0.980	1.000
258	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	DLL1(1), NOTCH1(4)	1349431	5	5	4	3	1	1	2	0	1	0	0.900	0.980	1.000
259	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	APOBEC3F(1)	984812	1	1	1	0	0	0	1	0	0	0	0.764	0.983	1.000
260	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(1), CR2(2), HLA-DRB1(3), ICAM1(1), ITGAL(1)	2075799	8	8	8	5	2	0	3	1	2	0	0.940	0.984	1.000
261	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(1), ATP6V0C(1), MTHFD1(1), MTHFD1L(1), MTHFR(1), MTR(1), SHMT2(1)	2440169	7	7	7	3	2	0	2	3	0	0	0.746	0.984	1.000
262	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS3(1), PON1(1)	1225164	2	2	2	5	0	0	0	1	1	0	1.000	0.984	1.000
263	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(1), EP300(2), ESR1(1), MAPK1(1), PELP1(1)	2057460	6	6	6	3	0	0	2	2	2	0	0.943	0.985	1.000
264	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(2), ARSD(2), GAL3ST1(1), GALC(1), LCT(1), PPAP2C(1), SPTLC1(1), SPTLC2(1)	3318796	10	9	10	3	1	0	8	0	1	0	0.537	0.987	1.000
265	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	IL4R(1), JAK1(1), JAK3(3), STAT6(1)	2032611	6	5	6	2	1	1	2	2	0	0	0.704	0.987	1.000
266	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), HLA-DRB1(3), LCK(1), ZAP70(1)	1249592	6	6	6	3	0	0	4	1	1	0	0.832	0.988	1.000
267	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(1), CASP8(1), DFFA(1), GZMB(1), LMNB1(1), LMNB2(2)	2637896	7	6	7	3	4	0	0	0	3	0	0.853	0.988	1.000
268	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ARPC2(1), PDGFRA(1), PIK3CA(1), PIK3R1(1)	1831299	4	4	4	6	0	0	1	2	1	0	0.999	0.990	1.000
269	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(1), IL3(1), JAK2(2), PTPN6(1), STAT5B(1)	2431806	6	4	6	2	0	0	2	2	2	0	0.797	0.990	1.000
270	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6R(1), JAK1(1), JAK2(2), JAK3(3), PTPRU(1)	2121410	8	7	8	3	1	0	4	3	0	0	0.731	0.990	1.000
271	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH6(1), ADH7(2)	1821558	3	3	3	6	1	0	0	1	1	0	1.000	0.991	1.000
272	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	JAK1(1), PTPRU(1), TYK2(2)	1718758	4	3	4	2	0	0	2	0	2	0	0.861	0.991	1.000
273	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	BCL2L1(2), H2AFX(1), NFKB1(1), PIK3CA(1), PIK3R1(1)	2695438	6	5	6	2	1	0	3	1	1	0	0.766	0.991	1.000
274	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	BST1(2), NADSYN1(2), NMNAT3(1), NNT(1), NT5C1A(1), NT5C1B(2), NT5E(1), NT5M(1)	2925904	11	9	10	5	1	2	5	0	3	0	0.851	0.992	1.000
275	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP8(1), DAXX(4), DFFA(1), FADD(2), LMNB1(1), LMNB2(2), MAP3K1(2), PRKDC(3), PTPN13(2), RB1(2), RIPK2(1), SPTAN1(3)	5837396	24	16	24	5	7	2	4	2	9	0	0.440	0.992	1.000
276	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F5(2), PROC(1), PROS1(1), TFPI(1)	2253243	5	5	5	2	1	0	2	2	0	0	0.736	0.992	1.000
277	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ELOVL5(2), FADS2(1), FASN(3), HADHA(1)	2114071	7	6	7	5	0	0	2	3	2	0	0.992	0.992	1.000
278	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CXCR4(1), PLCG1(3)	1850128	4	4	4	3	2	0	1	0	1	0	0.929	0.992	1.000
279	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AOC3(1), DDHD1(3), ESCO2(1), PNPLA3(2)	3395984	7	6	6	2	3	0	1	3	0	0	0.584	0.993	1.000
280	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMKK2(1)	1640507	1	1	1	1	0	0	1	0	0	0	0.942	0.994	1.000
281	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	EPO(1), GRIN1(1), JAK2(2), NFKB1(1)	1819764	5	3	5	2	0	0	3	2	0	0	0.808	0.994	1.000
282	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	ST3GAL1(1)	1664404	1	1	1	1	0	0	0	1	0	0	0.955	0.994	1.000
283	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	NFKB1(1), PIK3CA(1), PIK3R1(1)	1939192	3	3	3	2	0	0	2	1	0	0	0.919	0.995	1.000
284	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CRY2(1), NR1D1(1), PER1(1), PER3(3)	2349770	6	4	6	2	1	0	3	0	2	0	0.751	0.995	1.000
285	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	GOT1(1), GOT2(2), GPT2(2), MDH2(1), ME2(1), RPIA(1)	2476032	8	7	8	4	2	1	3	0	2	0	0.863	0.995	1.000
286	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	BPNT1(3), MAPK1(1), PIK3CA(1)	2747034	5	4	5	2	0	0	1	2	1	1	0.934	0.995	1.000
287	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	EIF2B5(1), IGF1R(1), PIK3CA(1), PIK3R1(1)	2707236	4	4	4	2	1	0	2	1	0	0	0.848	0.995	1.000
288	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	NGFR(2), NTRK1(1), PIK3CA(1)	2284819	4	4	4	2	2	0	1	1	0	0	0.815	0.995	1.000
289	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD3D(1), CXCR3(2), JAK2(2), TYK2(2)	2068886	7	3	7	4	1	0	1	3	2	0	0.926	0.996	1.000
290	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	CA3(1), CPS1(3), CTH(1), GLUD1(1)	2577614	6	4	6	5	1	0	2	1	2	0	0.982	0.996	1.000
291	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	ICAM1(1), ITGA4(1), ITGAL(1), ITGAM(2), SELE(1), SELP(2)	2238692	8	6	8	4	1	0	4	2	0	1	0.878	0.996	1.000
292	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	GOSR2(2), STX18(1), STX19(1), STX7(1), TSNARE1(2), VAMP1(1), VTI1B(1)	2337003	9	9	9	4	1	0	2	4	2	0	0.858	0.996	1.000
293	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BFAR(1), BRAF(1), MAPK1(1)	1577798	3	3	3	2	0	0	1	2	0	0	0.930	0.996	1.000
294	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD3D(1), ICAM1(1), ITGAL(1)	1529295	3	3	3	2	1	0	2	0	0	0	0.865	0.996	1.000
295	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	ICAM1(1), ITGAL(1), ITGAM(2), SELE(1)	1490071	5	5	5	3	1	0	2	2	0	0	0.892	0.997	1.000
296	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ARPC2(1), NCKAP1(1), NTRK1(1), WASF2(1)	2089405	4	4	4	4	0	0	2	1	1	0	0.987	0.997	1.000
297	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMB1(2), PSMB3(1), PSMB5(1), RPN2(2), UBE3A(1)	1798016	7	2	7	2	2	0	5	0	0	0	0.638	0.997	1.000
298	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1S(1), C2(1), C6(1), C7(1), C9(3)	2433350	7	7	7	4	1	0	3	2	1	0	0.876	0.997	1.000
299	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	JAK1(1), JAK2(2), JAK3(3), STAT5B(1), TYK2(2)	2588447	9	7	9	4	1	0	2	3	3	0	0.878	0.997	1.000
300	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(1), ALOX12(1), ALOX12B(1), ALOX5(3), CYP2B6(3), CYP2C9(1), CYP2J2(1), CYP2U1(2), CYP4A22(4), CYP4F2(1), CYP4F3(1), GPX1(1), GPX7(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PTGDS(1), PTGS1(1), PTGS2(1)	5499927	31	17	31	9	2	3	14	5	7	0	0.600	0.998	1.000
301	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	BAG4(1), CASP8(1), DFFA(1), FADD(2), LMNB1(1), LMNB2(2), MAP3K1(2), PRKDC(3), RB1(2), SPTAN1(3), TNFRSF1A(1)	5448544	19	15	19	5	7	1	4	0	7	0	0.559	0.998	1.000
302	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ACACA(2), ALDH6A1(1), ECHS1(2), EHHADH(1), HADHA(1), LDHA(3), MUT(1), PCCA(1), SDS(1)	4467642	13	11	13	4	3	0	7	1	2	0	0.651	0.998	1.000
303	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	52	CREBBP(1), GATA4(1), LIF(1), MAPK1(1), MEF2C(2), MYH2(2), NFATC1(1), NKX2-5(1), PIK3CA(1), PIK3R1(1), PPP3CB(1), PRKACB(1), PRKAR1A(7)	6856660	21	13	20	6	0	1	7	5	8	0	0.757	0.998	1.000
304	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(2), ACACB(4), FASN(3), OLAH(1)	2259396	10	8	10	5	1	0	5	3	1	0	0.916	0.998	1.000
305	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	CA3(1), CPS1(3), CTH(1), GLUD1(1), GLUD2(1)	2878700	7	5	7	6	2	0	2	1	2	0	0.987	0.998	1.000
306	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(1), EP300(2), JAK1(1), JAK3(3), LCK(1), PIK3CA(1), PIK3R1(1), STAT5B(1)	3816725	11	10	11	3	1	0	5	2	3	0	0.697	0.998	1.000
307	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), F2RL1(1), MAPK1(1), MAPK7(2), MYEF2(1), PLD2(1), TEC(1), VAV1(3)	3801255	11	9	10	3	2	0	6	1	2	0	0.550	0.999	1.000
308	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(4), B4GALT5(2), C1GALT1(1), GALNT10(1), GALNT12(2), GALNT14(1), GALNT3(2), GALNT4(1), GALNT5(1), GALNT8(2), OGT(1), ST3GAL1(1), ST6GALNAC1(1)	4428512	20	14	17	6	3	1	5	4	7	0	0.797	0.999	1.000
309	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(1), ALOX5(3), PTGDS(1), PTGS1(1), PTGS2(1)	2174199	7	7	7	5	0	1	3	2	1	0	0.976	0.999	1.000
310	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(4), CDH1(1), CREBBP(1), EP300(2), SKIL(1), TGFBR2(2)	3488080	11	10	11	6	0	0	6	2	3	0	0.983	0.999	1.000
311	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	NADSYN1(2), NNT(1), NT5E(1), NT5M(1)	1987836	5	4	5	5	1	2	1	0	1	0	0.988	0.999	1.000
312	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	CTH(1), DNMT3B(1), MARS(1), MARS2(1), MTR(1)	2411145	5	5	5	7	1	1	0	2	1	0	0.999	0.999	1.000
313	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGFR(3), MAP3K1(2), NCOR2(4), RARA(1), THRA(1)	2392065	11	9	11	5	3	0	4	3	1	0	0.873	0.999	1.000
314	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	ITPR1(2), ITPR2(4), ITPR3(5), TF(1)	4984271	12	10	12	3	2	0	5	5	0	0	0.483	0.999	1.000
315	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	MUSK(3), PIK3CA(1), PIK3R1(1), TERT(1)	2308521	6	6	6	3	1	1	2	2	0	0	0.868	0.999	1.000
316	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3D(1), CXCR3(2), ETV5(2), IL18R1(2), JAK2(2), TYK2(2)	2571835	11	7	11	6	2	0	3	4	2	0	0.929	0.999	1.000
317	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1S(1), C2(1), C6(1), C7(1), C8B(1), C9(3)	2877130	8	8	8	4	2	0	3	2	1	0	0.813	0.999	1.000
318	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(1), CS(1), DLST(1), FH(1), IDH3G(1), MDH2(1), PC(1), PCK1(1), SDHA(1), SDHB(1)	2825244	10	6	10	4	0	1	7	2	0	0	0.756	0.999	1.000
319	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	BDKRB2(1), FLT4(6), KDR(1), NOS3(4), PDE2A(1), PDE3A(2), PDE3B(1), PRKACB(1), PRKAR1A(7), PRKG2(2), RYR2(12)	5792409	38	23	37	10	8	4	10	6	10	0	0.417	0.999	1.000
320	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS3(1), ESCO2(1), PNPLA3(2)	2189249	4	3	4	3	0	0	1	2	1	0	0.959	0.999	1.000
321	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	EPO(1), JAK2(2), PLCG1(3), PTPN6(1), STAT5B(1)	2991336	8	6	8	4	2	0	2	2	2	0	0.892	0.999	1.000
322	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CTH(1), LCMT1(1), MARS(1), MARS2(1), PAPSS2(1), SCLY(1), WBSCR22(1)	3431645	7	6	7	7	1	1	2	1	2	0	0.995	0.999	1.000
323	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	DHRS3(1), LCMT1(1), WBSCR22(1)	2048454	3	3	3	5	0	1	1	0	1	0	0.995	0.999	1.000
324	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR3(1), CCR4(1), CXCR3(2), CXCR4(1), IL18R1(2), IL2(1), IL4R(1)	2769860	9	9	9	8	2	1	3	2	1	0	0.990	0.999	1.000
325	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1S(1), C2(1), C6(1), C7(1), C9(3)	2970998	7	7	7	5	1	0	3	2	1	0	0.929	0.999	1.000
326	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	DHRS3(1), ECHS1(2), EHHADH(1), ESCO2(1), HADHA(1), PNPLA3(2)	3487588	8	6	8	3	0	0	3	2	3	0	0.835	0.999	1.000
327	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(1), POLR1C(2), POLR2B(2), POLR2H(1)	3178546	6	5	6	2	1	0	4	0	1	0	0.775	0.999	1.000
328	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACO1(1), ACSS2(1), FH(1), MDH2(1)	1809270	4	2	4	2	0	0	4	0	0	0	0.854	1.000	1.000
329	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(2), EPN1(1), PICALM(1), PPP3CB(1), SYNJ1(1)	3108675	6	6	6	3	0	0	6	0	0	0	0.844	1.000	1.000
330	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX5(3), CYP2C9(1), CYP2J2(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1)	3318866	12	8	12	9	1	1	6	2	2	0	0.985	1.000	1.000
331	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(1), ALDH5A1(1), ECHS1(2), EHHADH(1), HADHA(1), OXCT1(1), PDHB(1), SDHB(1), SDS(1)	3516086	10	7	10	4	1	0	4	3	2	0	0.819	1.000	1.000
332	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ALDH5A1(1), CAD(1), CPS1(3), EARS2(2), EPRS(3), GLUD1(1), GLUD2(1), GMPS(1), GOT1(1), GOT2(2), GPT2(2), GSS(1), NADSYN1(2), QARS(1)	5408752	22	14	22	5	4	3	5	5	5	0	0.434	1.000	1.000
333	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(1), HS3ST2(3), HS3ST3A1(2), HS3ST5(2), HS6ST1(1), HS6ST2(1), NDST2(1), NDST4(2)	2866477	13	8	13	8	1	0	6	4	2	0	0.960	1.000	1.000
334	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(1), EP300(2), NCOA1(2), NCOA2(1)	2485018	6	6	6	3	0	0	4	1	1	0	0.933	1.000	1.000
335	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CEBPB(1), IL6R(1), JAK1(1), JAK2(2), JAK3(3), PTPN11(1), SRF(1)	3289640	10	8	10	4	2	0	3	4	1	0	0.827	1.000	1.000
336	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	NFKB1(1)	1987187	1	1	1	1	0	0	1	0	0	0	0.949	1.000	1.000
337	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(1), CAPN2(3), CAPNS1(1), EP300(2), HDAC1(1), HDAC2(1), NFATC1(1), PPP3CB(1)	3296266	11	10	11	6	1	0	7	1	2	0	0.911	1.000	1.000
338	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(1), BCL2L1(2), CASP8(1), DAXX(4), DFFA(1), FADD(2), NFKB1(1), NGFR(2), NTRK1(1), PTPN13(2), TNFRSF1A(1)	5997560	18	14	18	9	5	2	3	2	6	0	0.951	1.000	1.000
339	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	IL2(1), MAP3K1(2), NFKB1(1), TNFSF9(2)	2706409	6	5	6	3	2	0	4	0	0	0	0.868	1.000	1.000
340	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(2), CALCR(1), CALCRL(1), CD97(1), ELTD1(2), EMR1(1), EMR2(4), GIPR(1), GLP1R(1), GPR64(1), LPHN1(3), LPHN2(1), LPHN3(3), VIPR1(1), VIPR2(1)	3837139	24	17	23	9	3	1	13	5	2	0	0.689	1.000	1.000
341	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C6(1), C7(1), ICAM1(1), ITGA4(1), ITGAL(1), SELP(2)	3381752	7	6	7	5	1	0	5	0	0	1	0.949	1.000	1.000
342	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(2), BCAT2(1), IARS(1), LARS(1), LARS2(1), PDHB(1), VARS(8), VARS2(1)	2527155	16	14	11	6	1	0	10	3	2	0	0.816	1.000	1.000
343	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP5(1), ACP6(1), ACPP(1), ALPI(1), ALPP(1), ALPPL2(8), DHRS3(1), PON1(1)	2494801	15	13	9	8	0	9	3	2	1	0	0.886	1.000	1.000
344	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	GMPPB(1), HK2(3), HK3(3), KHK(2)	3335159	9	9	9	4	2	0	5	1	1	0	0.728	1.000	1.000
345	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	AOC3(1), MAOA(3)	3371374	4	3	4	4	1	0	1	0	2	0	0.986	1.000	1.000
346	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	DAXX(4), EGFR(3), ETS2(1), MAP2K3(2), MAP3K1(2), MAPK1(1), NFKB1(1), PRKCG(1), PRKCH(1), PRKCQ(2), TNFRSF1A(1)	6512329	19	17	19	7	3	1	6	3	6	0	0.812	1.000	1.000
347	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	BCR(2), JAK2(2), MAP3K1(2), PIK3CA(1), PIK3R1(1), STAT5B(1)	3761721	9	7	9	5	1	0	3	3	2	0	0.964	1.000	1.000
348	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	AOC3(1), DPYD(2), DPYS(2), ECHS1(2), EHHADH(1), HADHA(1), SDS(1)	3932161	10	8	10	5	3	0	4	0	3	0	0.847	1.000	1.000
349	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	CYP2C9(1), DHRS3(1), ECHS1(2), EHHADH(1), ESCO2(1), HADHA(1), PNPLA3(2)	4174357	9	6	9	4	0	0	4	2	3	0	0.876	1.000	1.000
350	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	GNB1(2), MAPK1(1), PLA2G4A(3), PLCB1(3), PTGS1(1), SYK(1)	3303619	11	8	11	6	1	0	6	3	1	0	0.939	1.000	1.000
351	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(1), B3GALNT1(1), B3GALT2(1), B3GALT4(1), B3GALT5(1), FUT3(3), FUT4(1), FUT6(2), GBGT1(2), GCNT2(1), PIGG(2), PIGO(1), PIGU(2), PIGZ(1), ST3GAL1(1), ST6GALNAC3(1), ST6GALNAC5(1)	6770814	23	13	23	5	5	0	9	5	4	0	0.378	1.000	1.000
352	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	IL2(1), JAK1(1), JAK3(3), LCK(1), STAT5B(1), SYK(1)	3252583	8	7	8	4	1	0	4	1	2	0	0.883	1.000	1.000
353	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	EIF1(1), EIF2B5(1), FLT4(6), KDR(1), NOS3(4), PIK3CA(1), PIK3R1(1), PLCG1(3)	4737251	18	16	18	6	6	3	5	4	0	0	0.562	1.000	1.000
354	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(1), GNAS(5), GNB1(2), MAPK1(1), NOX1(1), PIK3C2G(1), PLCB1(3)	3502131	15	13	15	7	2	0	6	5	2	0	0.917	1.000	1.000
355	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(1), ARF3(1), ARL4D(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0C(1), ATP6V0D2(1), ATP6V1A(1), ATP6V1E2(1), GNAS(5), PDIA4(1), PLCG1(3)	5114318	21	16	21	9	4	2	8	3	4	0	0.846	1.000	1.000
356	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(2), COL4A2(1), COL4A5(2), COL4A6(4), P4HB(1), SLC23A2(1)	3550398	11	10	11	7	2	1	5	1	2	0	0.912	1.000	1.000
357	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	65	APAF1(1), ATM(5), ATR(3), CASP8(1), CCNB3(2), CCND2(1), CDKN2A(2), CHEK2(2), DDB2(1), GADD45G(2), GTSE1(1), IGFBP3(1), MDM2(2), PMAIP1(1), RRM2(1), SERPINE1(1), SESN1(1), THBS1(1), TP53(18), TP53I3(1), TP73(1), TSC2(1)	9011640	50	32	50	11	6	0	14	6	23	1	0.496	1.000	1.000
358	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(1), CDIPT(1), CHAT(1), CHKB(1), CHPT1(2), DGKB(1), DGKD(2), DGKH(1), DGKI(1), DGKZ(6), ESCO2(1), GNPAT(1), GPAM(2), PCYT1B(1), PEMT(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLD2(1), PNPLA3(2), PPAP2C(1)	9197526	34	19	32	8	4	1	15	9	5	0	0.351	1.000	1.000
359	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), B4GALT5(2), MGAT3(1), RPN2(2)	2763978	6	4	6	3	2	0	2	2	0	0	0.874	1.000	1.000
360	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTN1(2), ACTN2(2), CAPNS1(1), SPTAN1(3), TLN1(2)	3982161	10	8	10	4	4	1	4	0	1	0	0.652	1.000	1.000
361	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDHPPT(1), ATP6V0C(1), DLST(1), DOT1L(2), ECHS1(2), EHHADH(1), EHMT1(3), EHMT2(1), HADHA(1), PLOD3(2), SDS(1), SHMT2(1)	5013618	17	10	17	6	3	1	8	1	4	0	0.709	1.000	1.000
362	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F5(2), F8(2), F9(1), LPA(1), PLAT(1), PLG(1), SERPINB2(1), SERPINE1(1), VWF(6)	4757383	16	12	16	8	2	1	6	4	3	0	0.896	1.000	1.000
363	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACSL1(3), ACSL3(2), ADH6(1), ADH7(2), CPT1C(1), CYP4A22(4), ECHS1(2), EHHADH(1), HADH(1), HADHA(1), HADHB(1), HSD17B4(3)	6677058	22	16	22	8	3	2	8	4	5	0	0.771	1.000	1.000
364	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ARRB2(1), CALML3(1), CALML6(1), GNAL(2), PDE1C(1), PRKACA(1), PRKACB(1), PRKG2(2)	4238383	10	9	10	7	2	0	3	3	2	0	0.985	1.000	1.000
365	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(2), AOC3(1), ATP6V0C(1), CHDH(6), CHKB(1), CTH(1), DAO(1), GARS(35), GCAT(2), MAOA(3), PEMT(1), PLCG1(3), SARDH(1), SHMT2(1)	5881043	59	47	21	16	6	1	38	10	4	0	0.314	1.000	1.000
366	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	APOE(9), HMGCR(1), LDLR(1), LRP1(6), SCARB1(3)	3739948	20	15	12	6	6	0	4	9	1	0	0.560	1.000	1.000
367	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(1), CXCR4(1), GNB1(2), MAPK1(1), NFKB1(1), PIK3C2G(1), PIK3CA(1), PIK3R1(1), PLCG1(3)	3887319	12	12	12	9	2	0	7	2	1	0	0.987	1.000	1.000
368	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(1), GNB1(2), MAPK1(1), PDGFRA(1), PIK3CA(1), PIK3R1(1), PLCB1(3), SPHK1(2)	3696675	12	10	12	9	2	0	4	5	1	0	0.990	1.000	1.000
369	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS2(1), ADSS(1), ADSSL1(3), AGXT(2), CAD(1), DDO(1), GOT1(1), GOT2(2), GPT2(2), PC(1), PDHB(1)	5225599	16	14	15	5	5	2	4	3	2	0	0.631	1.000	1.000
370	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	JAK2(2), MPL(1), PIK3CA(1), PIK3R1(1), PLCG1(3), STAT5B(1)	4054873	9	7	9	5	2	0	2	3	2	0	0.964	1.000	1.000
371	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(1), MAP2K3(2), MAP3K1(2), MAPK1(1), PLCG1(3)	3913094	9	8	9	4	3	0	4	2	0	0	0.778	1.000	1.000
372	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	67	APAF1(1), BCL2L1(2), BCL2L11(1), BIRC5(1), CASP8(1), DFFA(1), FADD(2), GZMB(1), HELLS(1), IRF2(3), IRF3(1), IRF4(1), IRF5(1), IRF6(1), MAP3K1(2), MDM2(2), NFKB1(1), NFKBIE(2), PLEKHG5(1), TNFRSF1A(1), TNFRSF21(1), TP53(18), TP73(1)	7937309	47	30	47	12	9	1	15	3	18	1	0.443	1.000	1.000
373	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(1), DUSP1(1), EP300(2), MAP2K3(2), MAPK11(1), NFKB1(1), TGFBR2(2), TLR2(2)	4050233	12	8	12	6	0	0	7	3	2	0	0.956	1.000	1.000
374	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	GAA(1), GALK2(1), HK2(3), HK3(3), LCT(1), MGAM(4)	4470728	13	10	13	5	1	0	8	2	2	0	0.730	1.000	1.000
375	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	BCL2L1(2), CBL(1), JAK1(1), JAK3(3), MAPK1(1), PIK3CA(1), PIK3R1(1), PTPN6(1), STAT5B(1), SYK(1)	4944580	13	11	13	7	2	1	4	3	3	0	0.949	1.000	1.000
376	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	APC(4), AR(2), BRAF(1), EGFR(3), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), PHKA2(2), PIK3CA(1), PIK3R1(1), PITX2(3), PTX3(1)	7420063	30	20	30	8	5	0	13	10	2	0	0.466	1.000	1.000
377	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	CMA1(1), COL4A1(2), COL4A2(1), COL4A5(2), COL4A6(4)	3511236	10	9	10	6	2	1	5	1	1	0	0.890	1.000	1.000
378	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BTK(1), MAP3K1(2), NFATC1(1), PLCG1(3), PPP3CB(1), SYK(1), VAV1(3)	5176187	12	7	12	4	5	0	5	0	2	0	0.640	1.000	1.000
379	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(4), MAPK1(1), MAPK8IP3(2)	3923105	7	4	7	5	0	0	4	2	1	0	0.971	1.000	1.000
380	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(1), CASP8(1), DFFA(1), FADD(2), NFKB1(1), SPTAN1(3), TNFRSF10A(1)	4606724	10	8	10	8	4	1	3	0	2	0	0.983	1.000	1.000
381	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	EIF4G1(1), MAPK1(1), MKNK1(1), PABPC1(5), PIK3CA(1), PIK3R1(1)	3784297	10	10	8	5	1	0	4	4	1	0	0.915	1.000	1.000
382	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	21	BTK(1), EEA1(2), PFKL(2), PLCG1(3), VAV2(1)	3296022	9	8	9	5	3	0	3	2	1	0	0.877	1.000	1.000
383	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	EIF4G1(1), MKNK1(1), PIK3CA(1), PIK3R1(1), TSC2(1)	3771220	5	5	5	5	1	0	2	1	1	0	0.992	1.000	1.000
384	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA2(1), POLD1(2), POLD2(1), POLE(3), POLG(1), POLK(1), POLM(1), POLQ(1), REV3L(1), RFC5(1)	5636804	13	9	12	4	1	1	6	3	2	0	0.778	1.000	1.000
385	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH6(1), ADH7(2), AOC3(1), DBH(2), DCT(1), ESCO2(1), GOT1(1), GOT2(2), HGD(1), LCMT1(1), MAOA(3), MIF(3), PNPLA3(2), TH(3), TPO(22), TYRP1(1), WBSCR22(1)	8111349	48	35	28	13	7	1	32	4	4	0	0.347	1.000	1.000
386	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	IARS(1), IL13RA1(1), IL4R(1), INPP5D(1), JAK1(1), JAK2(2), JAK3(3), PIK3CA(1), SERPINA4(1), SOS2(1), STAT6(1), TYK2(2)	5052012	16	10	16	7	1	1	4	7	3	0	0.872	1.000	1.000
387	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(1), FCER1A(2), MAP3K1(2), MAPK1(1), NFATC1(1), PIK3CA(1), PIK3R1(1), PLA2G4A(3), PLCG1(3), PPP3CB(1), SYK(1), VAV1(3)	5830175	20	11	20	5	5	0	9	3	3	0	0.519	1.000	1.000
388	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG10(1), ALG13(3), ALG2(2), ALG3(1), ALG6(1), MAN2A1(1), MGAT3(1), RPN2(2)	5871798	12	10	12	6	1	0	6	2	3	0	0.884	1.000	1.000
389	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AFMID(1), AOC3(1), ECHS1(2), EHHADH(1), HADH(1), HADHA(1), HSD17B4(3), KMO(1), LCMT1(1), LNX1(2), MAOA(3), OGDHL(1), TDO2(1), WARS2(1), WBSCR22(1)	8279390	21	14	21	6	2	1	11	3	4	0	0.563	1.000	1.000
390	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	G6PC2(1), GAA(1), GALK2(1), HK2(3), HK3(3), LCT(1), MGAM(4), PFKL(2), UGP2(1)	5307105	17	11	17	7	2	0	9	4	2	0	0.780	1.000	1.000
391	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(1), ALDH5A1(1), DDHD1(3), ECHS1(2), EHHADH(1), HADH(1), HADHA(1), HMGCS2(1), HSD17B4(3), OXCT1(1), PDHB(1)	5619878	16	11	15	6	2	0	8	4	2	0	0.777	1.000	1.000
392	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ITGA9(1), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), PDE3A(2), PDE3B(1), PIK3C2G(1), PIK3CA(1), PIK3R1(1), SGCB(1), VASP(1)	6782969	21	15	21	6	2	0	11	7	1	0	0.528	1.000	1.000
393	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(2), ACACB(4), ACSS2(1), GRHPR(1), HAGH(1), LDHA(3), MDH2(1), ME2(1), PC(1), PCK1(1), PDHB(1)	6339221	17	13	17	9	3	1	8	3	2	0	0.943	1.000	1.000
394	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(2), GRHPR(1), HAGH(1), LDHA(3), MDH2(1), ME2(1), PC(1), PCK1(1), PDHB(1)	5007409	12	11	12	9	3	1	5	2	1	0	0.984	1.000	1.000
395	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AOC3(1), CYP2A6(1), CYP2B6(3), CYP2C9(1), CYP2J2(1), CYP4B1(1), ECHS1(2), EHHADH(1), HADHA(1), KMO(1), MAOA(3), SDS(1), TDO2(1), WARS2(1)	7505994	19	12	19	9	3	0	10	2	4	0	0.923	1.000	1.000
396	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC7(1), CDT1(1), DIAPH2(2), MCM3(1), NACA(3), POLA2(1), POLD1(2), POLD2(1), POLE(3), RFC1(1), RFC5(1), RPA2(1), RPA4(1), UBB(1)	6838299	20	13	19	6	3	1	7	6	3	0	0.718	1.000	1.000
397	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CD3D(1), LAT(1), LCK(1), MAP3K1(2), NFATC1(1), NFKB1(1), PIK3CA(1), PIK3R1(1), PLCG1(3), PPP3CB(1), PTPN7(1), VAV1(3), ZAP70(1)	6528357	18	11	18	5	5	0	9	1	3	0	0.547	1.000	1.000
398	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTN1(2), ACTN2(2), BCAR1(1), BCR(2), CAPNS1(1), CSK(1), MAPK1(1), ROCK1(2), TLN1(2), ZYX(1)	6535988	15	12	15	7	3	1	8	1	2	0	0.830	1.000	1.000
399	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(2), BLVRA(1), CP(1), EARS2(2), EPRS(3), MMAB(1), UGT1A3(1), UGT1A5(2), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B15(2), UGT2B28(1)	5676858	23	14	22	7	4	0	12	6	1	0	0.595	1.000	1.000
400	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	MAP3K1(2), MYLK(2), PDGFRA(1), PIK3CA(1), PIK3R1(1), TRIO(1), VAV1(3)	4774573	11	9	11	8	4	0	4	2	1	0	0.985	1.000	1.000
401	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC10(1), CDC16(2), CDC20(1), CDC27(1), CUL3(1), FZR1(2), ITCH(1), WWP1(1), WWP2(1)	5529011	11	9	11	6	1	0	3	6	1	0	0.949	1.000	1.000
402	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF2(2), EIF2AK1(1), EIF2AK3(1), EIF2B5(1), EIF4G1(1), PABPC1(5), PABPC3(3), PAIP1(1)	6061897	15	11	13	7	1	0	7	5	2	0	0.908	1.000	1.000
403	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	GSN(1), MAPK1(1), MYLK(2), PIK3CA(1), PIK3R1(1), ROCK1(2), TLN1(2)	5119802	10	9	10	6	1	0	6	2	1	0	0.943	1.000	1.000
404	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS2(1), CARS2(1), EARS2(2), EPRS(3), FARS2(1), FARSB(1), GARS(35), IARS(1), KARS(1), LARS(1), LARS2(1), MARS(1), MARS2(1), MTFMT(4), QARS(1), RARS2(2), VARS(8), VARS2(1), WARS2(1)	7351696	67	51	28	18	6	1	44	12	4	0	0.440	1.000	1.000
405	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(2), COL4A2(1), COL4A5(2), COL4A6(4), F5(2), F8(2), F9(1), PROC(1), PROS1(1), SERPING1(1)	6156391	17	14	17	9	2	1	8	5	1	0	0.912	1.000	1.000
406	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(4), CCND2(1), CTNNB1(14), DVL1(1), DVL2(1), FZD1(6), FZD5(1), FZD7(1), FZD8(2), LDLR(1), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(2), PRKD1(1), WNT1(2), WNT10A(1), WNT16(1), WNT2(1), WNT2B(1), WNT3(1), WNT4(1), WNT6(1)	7960275	47	31	37	14	5	1	15	10	15	1	0.828	1.000	1.000
407	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	DOCK1(2), GAB1(1), HGF(1), MAPK1(1), PIK3CA(1), PIK3R1(1), PTPN11(1)	6201277	8	7	8	7	0	1	3	3	1	0	0.992	1.000	1.000
408	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ACTG1(1), ARHGEF2(1), CD14(1), CDH1(1), CLDN1(1), CTNNB1(14), NCK2(1), ROCK1(2), TLR4(3), TUBA3E(1), TUBA8(2), TUBAL3(1), TUBB(1), WAS(1)	7059784	31	26	26	10	4	2	12	7	6	0	0.757	1.000	1.000
409	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ACTG1(1), ARHGEF2(1), CD14(1), CDH1(1), CLDN1(1), CTNNB1(14), NCK2(1), ROCK1(2), TLR4(3), TUBA3E(1), TUBA8(2), TUBAL3(1), TUBB(1), WAS(1)	7059784	31	26	26	10	4	2	12	7	6	0	0.757	1.000	1.000
410	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	152	BCL2L1(2), CBL(1), CBLC(1), CCND2(1), CNTFR(1), CREBBP(1), CSF2RA(1), CSF2RB(1), CSF3R(1), EP300(2), EPO(1), GH2(1), IFNA8(1), IFNAR2(1), IFNW1(1), IL13RA1(1), IL2(1), IL21R(2), IL23R(1), IL24(1), IL3(1), IL4R(1), IL6R(1), IL9R(3), IRF9(1), JAK1(1), JAK2(2), JAK3(3), LEPR(2), LIF(1), MPL(1), OSMR(4), PIAS2(2), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PTPN11(1), PTPN6(1), SOCS5(1), SOCS7(1), SOS2(1), SPRED1(1), STAM(1), STAT5B(1), STAT6(1), TPO(22), TYK2(2)	19969646	86	46	67	21	6	4	47	12	17	0	0.341	1.000	1.000
411	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	CREBBP(1), DUSP1(1), EHHADH(1), EP300(2), HSD17B4(3), MAPK1(1), NCOA1(2), NCOR1(1), NCOR2(4), NR2F1(3), NRIP1(3), PIK3CA(1), PIK3R1(1), PPARA(1), PRKACB(1), PRKAR1A(7), PTGS2(1), RB1(2), STAT5B(1)	8612103	37	26	36	11	2	1	12	9	13	0	0.766	1.000	1.000
412	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	237	ADCYAP1R1(2), ADRA2A(2), ADRA2B(1), ADRA2C(4), AVPR1A(3), AVPR1B(1), AVPR2(1), BDKRB2(1), C3AR1(1), CALCR(1), CALCRL(1), CHRM5(1), CYSLTR2(1), DRD3(1), DRD5(1), EDNRB(1), F2RL1(1), FPR1(2), FSHR(1), GABBR1(2), GABRA1(2), GABRA2(2), GABRA6(2), GABRB1(1), GABRB2(1), GABRB3(2), GABRD(1), GABRE(1), GABRG1(1), GABRG2(3), GABRG3(1), GABRR2(1), GALR3(1), GH2(1), GIPR(1), GLP1R(1), GLRA1(3), GLRB(1), GPR156(1), GPR50(4), GPR83(1), GRIA2(3), GRID1(1), GRID2(1), GRIK1(3), GRIK2(2), GRIK4(2), GRIK5(1), GRIN1(1), GRIN2B(2), GRIN2C(2), GRIN2D(1), GRIN3A(4), GRIN3B(7), GRM1(3), GRM3(3), GRM4(1), GRM5(1), GRM6(1), GRM8(4), HCRTR1(1), HTR2A(1), HTR2C(1), HTR5A(3), HTR6(1), KISS1R(3), LEPR(2), MC1R(1), MC3R(1), MCHR1(1), MCHR2(1), MTNR1A(2), MTNR1B(2), NPBWR2(1), NPFFR2(1), NPY1R(1), OPRD1(26), OPRL1(1), P2RX5(1), P2RY14(1), P2RY2(2), P2RY4(1), PARD3(1), PPYR1(3), PRLHR(2), PRSS1(1), PRSS3(1), PTGER4(1), PTGIR(1), RXFP1(1), SSTR1(1), SSTR2(1), SSTR3(2), SSTR4(2), TAAR5(3), TACR3(1), TBXA2R(1), THRA(1), TRPV1(1), UTS2R(4), VIPR1(1), VIPR2(1)	30387635	189	66	154	114	27	8	106	36	12	0	1.000	1.000	1.000
413	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTG1(1), ACTN1(2), ACTN2(2), ACTN4(1), BCAR1(1), BRAF(1), CAPN2(3), CCND2(1), COL11A1(1), COL1A1(1), COL1A2(1), COL2A1(1), COL4A1(2), COL4A2(1), COL4A6(4), COL5A1(5), COL5A2(3), COL5A3(2), COL6A1(2), COL6A2(3), COL6A3(2), COL6A6(2), CTNNB1(14), DOCK1(2), EGFR(3), FARP2(1), FLNA(3), FLNB(1), FLNC(1), FN1(1), HGF(1), IGF1R(1), ITGA10(2), ITGA2(1), ITGA2B(1), ITGA3(2), ITGA4(1), ITGA6(1), ITGA9(1), ITGB4(1), ITGB5(1), ITGB6(1), ITGB8(2), KDR(1), LAMA1(6), LAMA2(7), LAMA3(2), LAMA4(2), LAMA5(3), LAMB3(2), LAMB4(1), LAMC2(2), LAMC3(1), MAPK1(1), MYLK(2), MYLK2(2), PAK3(3), PAK4(1), PAK7(2), PARVG(1), PDGFD(1), PDGFRA(1), PDGFRB(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PIP5K1C(1), PPP1CA(2), PPP1R12A(1), PRKCG(1), RAPGEF1(1), RELN(7), ROCK1(2), SHC2(2), SHC3(1), SOS2(1), THBS1(1), THBS2(2), THBS4(2), TLN1(2), TLN2(6), TNC(3), TNN(4), TNR(5), TNXB(3), VASP(1), VAV1(3), VAV2(1), VAV3(3), VEGFB(1), VTN(1), VWF(6), ZYX(1)	51761335	197	64	192	76	38	10	82	36	30	1	0.945	1.000	1.000
414	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	248	ARRB1(1), ARRB2(1), ATF4(1), BDNF(1), BRAF(1), CACNA1A(10), CACNA1B(6), CACNA1C(1), CACNA1D(3), CACNA1E(3), CACNA1F(3), CACNA1G(2), CACNA1H(3), CACNA1I(2), CACNA1S(2), CACNA2D1(2), CACNA2D4(4), CACNB3(1), CACNB4(1), CACNG3(1), CACNG6(1), CACNG7(1), CD14(1), DAXX(4), DUSP1(1), DUSP6(1), DUSP7(3), ECSIT(1), EGFR(3), ELK4(1), FGF12(1), FGF13(1), FGF19(2), FGF21(1), FGF23(2), FGF3(1), FGF5(1), FGFR2(2), FGFR4(1), FLNA(3), FLNB(1), FLNC(1), GADD45G(2), MAP2K3(2), MAP3K1(2), MAP3K12(1), MAP3K13(1), MAP3K3(1), MAP3K4(1), MAP3K8(1), MAP4K3(1), MAP4K4(1), MAPK1(1), MAPK11(1), MAPK7(2), MAPK8IP3(2), MEF2C(2), MKNK1(1), NF1(9), NFKB1(1), NFKB2(1), NTF3(1), NTRK1(1), NTRK2(1), PDGFRA(1), PDGFRB(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PPP3CB(1), PPP5C(1), PRKACA(1), PRKACB(1), PRKCG(1), PTPN7(1), RAPGEF2(2), RASGRF1(2), RASGRF2(1), RASGRP1(2), RPS6KA1(1), RPS6KA4(2), RPS6KA6(1), SOS2(1), SRF(1), STK4(1), TAOK1(1), TAOK2(6), TAOK3(2), TGFBR2(2), TNFRSF1A(1), TP53(18)	40920000	178	63	169	96	32	10	71	24	40	1	1.000	1.000	1.000
415	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	CADM1(1), CADM3(2), CD276(1), CD8A(1), CD99(1), CDH1(1), CDH2(3), CDH3(1), CDH4(4), CDH5(2), CLDN1(1), CLDN23(13), CLDN5(3), CLDN9(1), CNTN1(2), CNTN2(1), CNTNAP1(1), CNTNAP2(1), CTLA4(2), ESAM(1), F11R(2), HLA-A(4), HLA-B(10), HLA-C(2), HLA-DOB(1), HLA-DQA1(2), HLA-DQB1(3), HLA-DRB1(3), HLA-F(1), HLA-G(1), ICAM1(1), ITGA4(1), ITGA6(1), ITGA9(1), ITGAL(1), ITGAM(2), ITGB8(2), L1CAM(1), MADCAM1(5), MAG(1), NFASC(1), NLGN1(1), NLGN2(4), NRCAM(2), NRXN1(3), NRXN2(3), PTPRF(2), PVR(1), PVRL1(2), PVRL3(1), SDC1(1), SDC4(1), SELE(1), SELP(2), VCAN(3)	20439582	116	57	97	63	21	6	53	23	12	1	0.999	1.000	1.000
416	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	137	ACTG1(1), COL11A1(1), COL17A1(1), COL1A1(1), COL1A2(1), COL2A1(1), COL4A1(2), COL4A2(1), COL4A6(4), COL5A1(5), COL5A2(3), COL5A3(2), COL6A1(2), COL6A2(3), COL6A3(2), COL6A6(2), DSC2(3), DSC3(2), DSG1(2), DSG2(1), DSG3(2), FN1(1), GJA1(2), GJA4(1), GJA8(1), GJB2(1), GJD3(1), GJD4(1), INA(1), ITGA6(1), ITGB4(1), KRT1(2), KRT12(2), KRT14(2), KRT17(1), KRT2(2), KRT20(1), KRT31(1), KRT32(3), KRT33A(1), KRT33B(3), KRT36(1), KRT39(2), KRT40(1), KRT6A(1), KRT71(1), KRT72(2), KRT73(1), KRT74(2), KRT75(1), KRT76(1), KRT77(2), KRT78(1), KRT81(1), KRT83(2), KRT84(1), LAMA1(6), LAMA2(7), LAMA3(2), LAMA4(2), LAMA5(3), LAMB3(2), LAMB4(1), LAMC2(2), LAMC3(1), LMNB1(1), LMNB2(2), RELN(7), THBS1(1), THBS2(2), THBS4(2), TNC(3), TNN(4), TNR(5), TNXB(3), VIM(1), VTN(1), VWF(6)	34657531	155	56	152	77	44	8	66	21	16	0	0.997	1.000	1.000
417	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	169	ADCY1(1), ADCY2(3), ADCY4(1), ADCY7(1), ADCY8(3), ATP2A1(2), ATP2A2(2), ATP2A3(1), ATP2B3(4), AVPR1A(3), AVPR1B(1), BDKRB2(1), BST1(2), CACNA1A(10), CACNA1B(6), CACNA1C(1), CACNA1D(3), CACNA1E(3), CACNA1F(3), CACNA1G(2), CACNA1H(3), CACNA1I(2), CACNA1S(2), CALML3(1), CALML6(1), CHRM5(1), CYSLTR2(1), EDNRB(1), EGFR(3), ERBB3(1), ERBB4(5), GNAL(2), GNAS(5), GRIN1(1), GRIN2C(2), GRIN2D(1), GRM1(3), GRM5(1), HTR2A(1), HTR2C(1), HTR5A(3), HTR6(1), ITPR1(2), ITPR2(4), ITPR3(5), MYLK(2), MYLK2(2), NOS1(2), NOS3(4), P2RX5(1), PDE1A(2), PDE1C(1), PDGFRA(1), PDGFRB(1), PHKA2(2), PHKB(3), PLCB1(3), PLCB3(1), PLCB4(1), PLCE1(2), PLCG1(3), PPP3CB(1), PRKACA(1), PRKACB(1), PRKCG(1), RYR1(4), RYR2(12), RYR3(4), SLC8A1(2), SLC8A2(2), SLC8A3(1), SPHK1(2), SPHK2(2), TACR3(1), TBXA2R(1), TRPC1(1)	38506507	173	55	164	96	39	10	74	30	20	0	1.000	1.000	1.000
418	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	130	ACTG1(1), ACTN1(2), ACTN2(2), ACTN4(1), ASH1L(1), CLDN1(1), CLDN23(13), CLDN5(3), CLDN9(1), CSDA(1), CTNNA2(1), CTNNA3(1), CTNNB1(14), EPB41(1), EPB41L1(1), EPB41L3(1), EXOC3(1), F11R(2), INADL(1), LLGL2(1), MAGI1(2), MAGI2(4), MAGI3(2), MPDZ(4), MPP5(1), MYH11(2), MYH13(1), MYH14(3), MYH15(3), MYH2(2), MYH3(2), MYH4(3), MYH6(4), MYH7(1), MYH8(4), PARD3(1), PPP2R1B(1), PPP2R3A(1), PPP2R3B(2), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(2), SPTAN1(3), SYMPK(2), TJAP1(1), TJP1(1), TJP2(1), TJP3(3), VAPA(1)	26660823	110	54	90	38	20	6	51	20	13	0	0.745	1.000	1.000
419	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	252	ACVR1(1), ACVR2B(1), AMH(1), AMHR2(1), BMPR1A(2), BMPR1B(1), BMPR2(1), CCL11(1), CCR3(1), CCR4(1), CCR6(2), CCR9(1), CNTFR(1), CSF1R(1), CSF2RA(1), CSF2RB(1), CSF3R(1), CX3CL1(1), CX3CR1(2), CXCL1(1), CXCL3(1), CXCL9(2), CXCR3(2), CXCR4(1), EGFR(3), EPO(1), FLT4(6), GDF5(1), GH2(1), HGF(1), IFNA8(1), IFNAR2(1), IFNW1(1), IL13RA1(1), IL17A(1), IL17RA(2), IL18R1(2), IL2(1), IL21R(2), IL23R(1), IL24(1), IL25(1), IL3(1), IL4R(1), IL6R(1), IL9R(3), INHBA(2), INHBB(3), KDR(1), LEPR(2), LIF(1), MPL(1), NGFR(2), OSMR(4), PDGFRA(1), PDGFRB(1), TGFBR2(2), TNFRSF10A(1), TNFRSF11A(1), TNFRSF1A(1), TNFRSF21(1), TNFRSF6B(1), TNFSF11(1), TNFSF9(2), TPO(22), VEGFB(1), XCL1(1)	24456563	115	51	95	43	23	4	62	14	12	0	0.738	1.000	1.000
420	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	163	ADRA2A(2), ADRA2C(4), AVPR1A(3), AVPR1B(1), AVPR2(1), BDKRB2(1), C3AR1(1), CCR3(1), CCR4(1), CCR6(2), CCR9(1), CHRM5(1), CX3CR1(2), CXCR3(2), CXCR4(1), DRD3(1), DRD5(1), EDNRB(1), F2RL1(1), FPR1(2), FSHR(1), GALR3(1), GPR173(2), GPR174(1), GPR3(1), GPR37(1), GPR4(3), GPR50(4), GPR6(1), GPR83(1), GPR85(1), HCRTR1(1), HTR2A(1), HTR2C(1), HTR5A(3), HTR6(1), MC1R(1), MC3R(1), MTNR1A(2), MTNR1B(2), NPY1R(1), OPRD1(26), OPRL1(1), OR2H1(1), OR7A5(1), P2RY12(1), P2RY14(1), P2RY2(2), PPYR1(3), PTGER4(1), PTGIR(1), SSTR1(1), SSTR2(1), SSTR3(2), SSTR4(2), TBXA2R(1)	16443523	106	50	77	70	16	3	63	19	5	0	1.000	1.000	1.000
421	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(1), COL11A1(1), COL1A1(1), COL1A2(1), COL2A1(1), COL4A1(2), COL4A2(1), COL4A6(4), COL5A1(5), COL5A2(3), COL5A3(2), COL6A1(2), COL6A2(3), COL6A3(2), COL6A6(2), FN1(1), FNDC1(3), GP6(2), GP9(2), HMMR(1), HSPG2(5), ITGA10(2), ITGA2(1), ITGA2B(1), ITGA3(2), ITGA4(1), ITGA6(1), ITGA9(1), ITGB4(1), ITGB5(1), ITGB6(1), ITGB8(2), LAMA1(6), LAMA2(7), LAMA3(2), LAMA4(2), LAMA5(3), LAMB3(2), LAMB4(1), LAMC2(2), LAMC3(1), RELN(7), SDC1(1), SDC4(1), SV2C(1), THBS1(1), THBS2(2), THBS4(2), TNC(3), TNN(4), TNR(5), TNXB(3), VTN(1), VWF(6)	31583923	122	49	120	47	24	7	55	23	12	1	0.853	1.000	1.000
422	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), ARRB1(1), ARRB2(1), ATP1A4(2), ATP1B1(1), ATP2A2(2), ATP2A3(1), ATP2B3(4), CACNA1A(10), CACNA1B(6), CACNA1C(1), CACNA1D(3), CACNA1E(3), CACNA1S(2), CACNB3(1), CHRM5(1), GJA1(2), GJA4(1), GJB2(1), GNB1(2), GRK4(1), ITPR1(2), ITPR2(4), ITPR3(5), KCNB1(1), PLCB3(1), PRKACA(1), PRKACB(1), PRKAR1A(7), PRKCG(1), PRKCH(1), PRKCQ(2), PRKD1(1), RGS1(1), RGS10(1), RGS18(3), RGS3(1), RYR1(4), RYR2(12), RYR3(4), SLC8A1(2), SLC8A3(1)	26587124	115	48	105	63	20	10	49	16	20	0	1.000	1.000	1.000
423	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	202	ACTN1(2), ACTN2(2), ACTN4(1), APC(4), APC2(2), ARHGEF1(1), ARHGEF4(2), ARPC2(1), BCAR1(1), BDKRB2(1), BRAF(1), CD14(1), CHRM5(1), CSK(1), CYFIP1(1), CYFIP2(2), DIAPH2(2), DIAPH3(1), DOCK1(2), EGFR(3), FGF12(1), FGF13(1), FGF19(2), FGF21(1), FGF23(2), FGF3(1), FGF5(1), FGFR2(2), FGFR4(1), FN1(1), GIT1(1), GSN(1), IQGAP2(1), IQGAP3(1), ITGA10(2), ITGA2(1), ITGA2B(1), ITGA3(2), ITGA4(1), ITGA6(1), ITGA9(1), ITGAE(1), ITGAL(1), ITGAM(2), ITGAX(1), ITGB4(1), ITGB5(1), ITGB6(1), ITGB8(2), LIMK2(1), MAPK1(1), MYH14(3), MYLK(2), MYLK2(2), NCKAP1(1), PAK3(3), PAK4(1), PAK7(2), PDGFRA(1), PDGFRB(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PIP4K2B(1), PIP5K1C(1), PPP1CA(2), PPP1R12A(1), ROCK1(2), SCIN(1), SLC9A1(1), SOS2(1), SSH1(1), TIAM1(3), TIAM2(3), VAV1(3), VAV2(1), VAV3(3), WAS(1), WASF2(1)	38882321	119	47	117	56	16	7	53	23	19	1	0.997	1.000	1.000
424	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	145	APC(4), APC2(2), CCND2(1), CHD8(1), CREBBP(1), CTBP2(4), CTNNB1(14), DAAM1(2), DAAM2(2), DKK1(1), DKK2(1), DVL1(1), DVL2(1), EP300(2), FZD1(6), FZD5(1), FZD7(1), FZD8(2), LRP6(1), NFATC1(1), NKD1(1), NKD2(1), PLCB1(3), PLCB3(1), PLCB4(1), PPP2R1B(1), PPP3CB(1), PRICKLE2(1), PRKACA(1), PRKACB(1), PRKCG(1), ROCK1(2), TBL1X(3), TCF7L2(1), TP53(18), WIF1(1), WNT1(2), WNT10A(1), WNT16(1), WNT2(1), WNT2B(1), WNT3(1), WNT4(1), WNT6(1)	22181187	96	46	85	45	11	3	29	18	33	2	1.000	1.000	1.000
425	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABLIM1(2), ABLIM2(1), ABLIM3(3), CXCR4(1), DCC(1), EFNA2(1), EPHA1(2), EPHA2(1), EPHA5(2), EPHA6(2), EPHA8(3), EPHB1(1), EPHB3(2), EPHB4(2), EPHB6(1), L1CAM(1), LIMK2(1), LRRC4C(3), MAPK1(1), NCK2(1), NFATC1(1), NTN1(1), NTN4(2), NTNG1(2), PAK3(3), PAK4(1), PAK7(2), PLXNA1(3), PLXNA2(4), PLXNA3(3), PLXNB2(3), PLXNB3(7), PLXNC1(1), PPP3CB(1), RGS3(1), RHOD(2), RND1(1), ROBO1(3), ROBO2(4), ROBO3(1), ROCK1(2), SEMA3D(3), SEMA3E(1), SEMA3G(2), SEMA4F(1), SEMA4G(1), SEMA5A(3), SEMA5B(17), SEMA6A(2), SEMA6B(1), SEMA6C(1), SEMA6D(2), SLIT1(2), SLIT2(6), UNC5A(2), UNC5B(1), UNC5C(2), UNC5D(2)	27496111	129	46	112	45	29	8	56	27	9	0	0.584	1.000	1.000
426	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(2), ASCC3(1), ATP13A2(1), DDX18(2), DDX4(2), DDX50(2), EP400(4), ERCC2(19), ERCC3(1), G6PC2(1), GAA(1), HK2(3), HK3(3), LYZL1(2), MGAM(4), MOV10L1(1), PYGL(1), RAD54B(1), RUVBL2(1), SETX(2), SI(5), SMARCA2(4), SMARCA5(1), UGP2(1), UGT1A3(1), UGT1A5(2), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B15(2), UGT2B28(1)	16973407	78	45	58	25	23	1	28	12	13	1	0.700	1.000	1.000
427	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(2), ACTN2(2), ACTN4(1), BCAR1(1), CD99(1), CDH5(2), CLDN1(1), CLDN23(13), CLDN5(3), CLDN9(1), CTNNA2(1), CTNNA3(1), CTNNB1(14), CXCR4(1), ESAM(1), F11R(2), ICAM1(1), ITGA4(1), ITGAL(1), ITGAM(2), ITK(1), MAPK11(1), MMP9(1), NOX1(1), NOX3(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PLCG1(3), PRKCG(1), PTPN11(1), RAPGEF3(1), RASSF5(3), ROCK1(2), VASP(1), VAV1(3), VAV2(1), VAV3(3)	17302380	83	44	66	24	11	2	39	17	13	1	0.543	1.000	1.000
428	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), CALML3(1), CALML6(1), CREB3L1(1), CREB3L3(2), CREBBP(1), CTNNB1(14), DCT(1), DVL1(1), DVL2(1), EDNRB(1), EP300(2), FZD1(6), FZD5(1), FZD7(1), FZD8(2), GNAS(5), MAPK1(1), MC1R(1), PLCB1(3), PLCB3(1), PLCB4(1), PRKACA(1), PRKACB(1), PRKCG(1), TCF7L2(1), TYRP1(1), WNT1(2), WNT10A(1), WNT16(1), WNT2(1), WNT2B(1), WNT3(1), WNT4(1), WNT6(1)	15094916	75	44	64	33	9	2	26	16	21	1	0.994	1.000	1.000
429	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	91	ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), AKAP1(2), AKAP11(1), AKAP12(4), AKAP2(7), AKAP4(2), AKAP5(1), AKAP6(1), AKAP8(2), AKAP9(3), ARHGEF1(1), GNAL(2), GNB1(2), ITPR1(2), PDE1A(2), PDE1C(1), PDE4B(1), PDE4C(2), PDE4D(1), PDE8A(1), PDE8B(2), PLCB3(1), PRKACA(1), PRKACB(1), PRKAR1A(7), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(2), PRKD1(1), SLC9A1(1)	16025462	70	43	62	31	15	1	25	12	17	0	0.981	1.000	1.000
430	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), ADSS(1), ADSSL1(3), AK5(2), ENTPD2(1), ENTPD4(3), ENTPD8(1), GDA(1), GMPS(1), GUCY1A3(1), GUCY2D(3), GUCY2F(2), IMPDH1(1), NME6(1), NT5C1A(1), NT5C1B(2), NT5E(1), NT5M(1), NUDT2(1), NUDT9(2), PAPSS2(1), PDE10A(1), PDE1A(2), PDE1C(1), PDE2A(1), PDE3B(1), PDE4B(1), PDE4C(2), PDE4D(1), PDE8A(1), PDE8B(2), PDE9A(1), POLA2(1), POLD1(2), POLD2(1), POLE(3), POLR1A(1), POLR1C(2), POLR2B(2), POLR2H(1), PRPS1L1(1), RFC5(1), RRM2(1), XDH(3)	22665622	76	43	73	35	11	6	35	17	7	0	0.982	1.000	1.000
431	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	ATP8A1(1), AVPR1A(3), AVPR1B(1), AVPR2(1), BDKRB2(1), C3AR1(1), CCR3(1), CCR4(1), CCR6(2), CX3CR1(2), CXCR3(2), CXCR4(1), EDNRB(1), FPR1(2), FSHR(1), GALR3(1), MC1R(1), MC3R(1), NPY1R(1), OPRD1(26), OPRL1(1), PPYR1(3), SSTR1(1), SSTR2(1), SSTR3(2), SSTR4(2), TACR3(1)	6997313	62	43	36	28	8	1	45	6	2	0	0.794	1.000	1.000
432	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	137	ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), ADM(1), ARRB1(1), ARRB2(1), ATF4(1), ATP2A2(2), ATP2A3(1), CACNB3(1), CALCA(1), CNN1(1), CORIN(1), DGKZ(6), ETS2(1), GABPB2(1), GJA1(2), GNB1(2), GRK4(1), GUCY1A3(1), IGFBP1(1), IGFBP3(1), IGFBP6(1), ITPR1(2), ITPR2(4), ITPR3(5), MYLK2(2), NFKB1(1), NOS1(2), NOS3(4), PDE4B(1), PDE4D(1), PLCB3(1), PLCG1(3), PRKACA(1), PRKACB(1), PRKAR1A(7), PRKCH(1), PRKCQ(2), PRKD1(1), RAMP3(2), RGS1(1), RGS10(1), RGS18(3), RGS3(1), RYR1(4), RYR2(12), RYR3(4), SLC8A1(2), TNXB(3)	24381283	113	43	109	69	16	7	50	22	18	0	1.000	1.000	1.000
433	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	CABIN1(1), CEBPB(1), CREBBP(1), CTLA4(2), EGR2(1), EGR3(1), EP300(2), FCER1A(2), FCGR3A(3), GATA3(2), GATA4(1), IL2(1), IL3(1), ITK(1), KPNA5(1), NCK2(1), NFATC1(1), NFKB2(1), NFKBIE(2), NUP214(2), OPRD1(26), PIN1(1), PPP3CB(1), RPL13A(1), SLA(2), VAV1(3), VAV2(1), VAV3(3)	12563088	66	40	41	36	4	0	50	6	6	0	0.999	1.000	1.000
434	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), EGFR(3), GJA1(2), GNAS(5), GRM1(3), GRM5(1), GUCY1A3(1), GUCY2D(3), GUCY2F(2), HTR2A(1), HTR2C(1), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), MAPK7(2), PDGFD(1), PDGFRA(1), PDGFRB(1), PLCB1(3), PLCB3(1), PLCB4(1), PRKACA(1), PRKACB(1), PRKCG(1), PRKG2(2), SOS2(1), TJP1(1), TUBA3E(1), TUBA8(2), TUBAL3(1), TUBB(1)	18323121	69	39	67	37	15	1	26	17	10	0	0.994	1.000	1.000
435	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	82	AIFM1(1), APAF1(1), ATM(5), BCL2L1(2), CAPN2(3), CASP8(1), CSF2RB(1), DFFA(1), FADD(2), IL3(1), IRAK1(2), IRAK2(2), NFKB1(1), NFKB2(1), NTRK1(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PPP3CB(1), PRKACA(1), PRKACB(1), PRKAR1A(7), TNFRSF10A(1), TNFRSF1A(1), TP53(18)	11573862	62	38	60	37	7	2	19	6	27	1	1.000	1.000	1.000
436	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), ADSS(1), AK5(2), ATP1B1(1), ATP5F1(1), ENTPD2(1), GDA(1), GMPS(1), GUCY1A3(1), GUCY2D(3), GUCY2F(2), IMPDH1(1), NT5E(1), NT5M(1), NUDT2(1), PAPSS2(1), PDE1A(2), PDE4B(1), PDE4C(2), PDE4D(1), PDE8A(1), PDE9A(1), POLD1(2), POLD2(1), POLE(3), POLG(1), POLQ(1), POLR2B(2), POLR2H(1), POLRMT(5), PRPS1L1(1), RRM2(1)	17761306	58	38	53	30	10	9	22	12	5	0	0.991	1.000	1.000
437	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(1), ADCY6(2), ADCY8(3), CACNA1A(10), CACNA1B(6), GNAS(5), GNB1(2), GRM4(1), ITPR3(5), KCNB1(1), PDE1A(2), PRKACA(1), PRKACB(1), SCNN1A(2), SCNN1B(2), TAS1R2(1), TAS2R3(1), TAS2R38(1), TAS2R4(1), TAS2R40(1), TAS2R41(1), TAS2R42(1), TAS2R43(4), TAS2R46(1), TAS2R5(1), TAS2R50(1)	8059546	58	37	51	26	8	6	34	5	5	0	0.925	1.000	1.000
438	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	84	CD14(1), CD19(2), CD1A(1), CD1C(1), CD1E(1), CD3D(1), CD8A(1), CD9(1), CR1(1), CR2(2), CSF1R(1), CSF2RA(1), CSF3R(1), EPO(1), GP9(2), HLA-DRB1(3), IL3(1), IL4R(1), IL6R(1), IL9R(3), ITGA2(1), ITGA2B(1), ITGA3(2), ITGA4(1), ITGA6(1), ITGAM(2), MME(3), TPO(22)	11331747	60	36	40	21	4	3	43	5	4	1	0.755	1.000	1.000
439	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	110	ANAPC10(1), ATM(5), ATR(3), CCNB3(2), CCND2(1), CDC14A(1), CDC16(2), CDC20(1), CDC27(1), CDC7(1), CDKN2A(2), CHEK2(2), CREBBP(1), DBF4(3), E2F3(1), EP300(2), ESPL1(1), FZR1(2), GADD45G(2), HDAC1(1), HDAC2(1), MAD1L1(1), MAD2L2(1), MCM3(1), MDM2(2), PRKDC(3), RB1(2), RBL1(1), SMC1A(2), TFDP1(1), TP53(18)	18617033	68	35	68	27	11	2	20	6	28	1	0.984	1.000	1.000
440	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(1), CANX(1), CD8A(1), CIITA(2), CTSL1(1), HLA-A(4), HLA-B(10), HLA-C(2), HLA-DOB(1), HLA-DQA1(2), HLA-DQB1(3), HLA-DRB1(3), HLA-F(1), HLA-G(1), HSP90AA1(1), HSP90AB1(1), HSPA5(1), IFNA8(1), KIR2DL1(1), KIR3DL2(1), NFYA(1), TAP1(1), TAP2(1)	6324416	42	35	39	22	2	4	15	13	8	0	0.997	1.000	1.000
441	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	BRAF(1), CACNA1A(10), GNAS(5), GRIA2(3), GRID2(1), GRM1(3), GRM5(1), GUCY1A3(1), GUCY2D(3), GUCY2F(2), IGF1R(1), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), NOS1(2), NOS3(4), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLCB1(3), PLCB3(1), PLCB4(1), PPP2R1B(1), PRKCG(1), PRKG2(2), RYR1(4)	15489759	69	35	66	47	10	1	31	18	9	0	1.000	1.000	1.000
442	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), ATF4(1), CACNA1C(1), CACNA1D(3), CACNA1F(3), CACNA1S(2), CALML3(1), CALML6(1), EGFR(3), GNAS(5), ITPR1(2), ITPR2(4), ITPR3(5), MAP2K3(2), MAP3K1(2), MAP3K3(1), MAP3K4(1), MAPK1(1), MAPK11(1), MAPK7(2), MMP14(2), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLCB1(3), PLCB3(1), PLCB4(1), PLD2(1), PRKACA(1), PRKACB(1), SOS2(1)	18055249	72	35	68	30	16	1	29	14	12	0	0.931	1.000	1.000
443	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	57	ASH1L(1), CTCFL(2), DOT1L(2), EHMT1(3), EHMT2(1), HCFC1(2), JMJD4(6), MEN1(8), MLL(5), MLL2(4), MLL3(7), MLL4(8), MLL5(1), NSD1(3), OGT(1), PPP1CA(2), PRDM6(2), PRDM9(5), SETD1A(1), SETD1B(2), SETD2(3), SETDB1(1), SETDB2(1), SETMAR(1), SUV420H1(1), WHSC1(1), WHSC1L1(1)	17382521	75	34	69	20	18	1	20	9	26	1	0.592	1.000	1.000
444	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACTG1(1), ACTN1(2), ACTN2(2), ACTN4(1), CDH1(1), CREBBP(1), CTNNA2(1), CTNNA3(1), CTNNB1(14), EGFR(3), EP300(2), FARP2(1), IGF1R(1), INSR(1), MAPK1(1), PARD3(1), PTPN6(1), PTPRF(2), PTPRJ(3), PVRL1(2), PVRL3(1), PVRL4(1), SORBS1(1), TCF7L2(1), TGFBR2(2), TJP1(1), WAS(1), WASF2(1)	16514835	51	34	46	18	9	2	21	9	10	0	0.815	1.000	1.000
445	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ATM(5), CCNB3(2), CCND2(1), CDC14A(1), CDC20(1), CDC7(1), CDH1(1), CDKN2A(2), CHEK2(2), DTX4(1), E2F3(1), EP300(2), ESPL1(1), HDAC1(1), HDAC2(1), HDAC4(1), HDAC6(2), MAD1L1(1), MAD2L2(1), MCM3(1), MDM2(2), MPL(1), PRKDC(3), PTPRA(1), RB1(2), RBL1(1), TBC1D8(2), TFDP1(1), TP53(18)	15264303	60	33	60	27	9	2	19	4	25	1	0.992	1.000	1.000
446	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1(1), AURKB(1), BMPR1A(2), BMPR2(1), CDIPT(1), CLK1(2), CLK2(1), COL4A3BP(1), DGKB(1), DGKD(2), DGKH(1), DGKZ(6), INPP4A(2), NEK1(1), OCRL(1), PAK4(1), PIK3C2G(1), PIK3CA(1), PIK3CB(1), PLCB1(3), PLCB3(1), PLCB4(1), PLCG1(3), PRKACA(1), PRKACB(1), PRKAR1A(7), PRKCG(1), PRKCH(1), PRKCQ(2), PRKD1(1), RPS6KA1(1), RPS6KA4(2), STK11(2)	15803361	55	33	52	40	11	2	14	13	15	0	1.000	1.000	1.000
447	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	ALG2(2), BFAR(1), BTK(1), CAD(1), CASP8(1), DAXX(4), DFFA(1), EGFR(3), FADD(2), MAP3K1(2), MAPK1(1), MAPK8IP3(2), NFKB1(1), NFKB2(1), NFKBIE(2), PTPN13(2), ROCK1(2), TNFRSF6B(1), TP53(18)	10226815	48	33	48	36	8	2	16	5	16	1	1.000	1.000	1.000
448	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	CREBBP(1), CTBP2(4), DLL1(1), DLL3(1), DTX2(2), DTX4(1), DVL1(1), DVL2(1), EP300(2), HDAC1(1), HDAC2(1), JAG2(1), MAML1(1), MAML3(2), NCOR2(4), NOTCH1(4), NOTCH2(11), NOTCH3(3), NOTCH4(2), PTCRA(2), RBPJL(2), SNW1(2)	9938986	50	32	38	33	7	14	15	7	7	0	1.000	1.000	1.000
449	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	BRAF(1), CD247(1), FCGR3A(3), GZMB(1), HLA-A(4), HLA-B(10), HLA-C(2), HLA-G(1), ICAM1(1), IFNA8(1), IFNAR2(1), ITGAL(1), KIR2DL1(1), KIR3DL2(1), LAT(1), LCK(1), MAPK1(1), MICA(2), MICB(1), NFATC1(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PLCG1(3), PPP3CB(1), PRKCG(1), PTPN11(1), PTPN6(1), SHC2(2), SHC3(1), SOS2(1), SYK(1), TNFRSF10A(1), VAV1(3), VAV2(1), VAV3(3), ZAP70(1)	15544815	64	32	61	21	11	4	21	12	16	0	0.800	1.000	1.000
450	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	65	ATM(5), CCND2(1), CDKN2A(2), CREB3L1(1), CREB3L3(2), E2F3(1), MCM3(1), MDM2(2), NACA(3), POLA2(1), POLE(3), RB1(2), RBL1(1), RPA2(1), TFDP1(1), TNXB(3), TP53(18)	10476255	48	31	47	22	8	2	13	4	20	1	0.983	1.000	1.000
451	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(1), EGFR(3), ERBB4(5), ETS2(1), FMN2(3), MAPK1(1), NOTCH1(4), NOTCH2(11), NOTCH3(3), NOTCH4(2), PIWIL1(1), PIWIL3(2), SOS2(1), SPIRE2(4)	7213331	42	29	30	18	7	12	10	7	6	0	0.920	1.000	1.000
452	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP5F1(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0C(1), ATP6V0D2(1), ATP6V1A(1), ATP6V1E2(1), COX4I1(1), COX4I2(1), COX6B1(1), COX7A1(1), LHPP(2), NDUFA1(1), NDUFA10(2), NDUFA12(1), NDUFB10(1), NDUFB11(2), NDUFB5(2), NDUFB7(1), NDUFB8(1), NDUFS2(1), PPA1(1), SDHA(1), SDHB(1), SDHD(1), TCIRG1(1), UQCRFS1(12)	7782988	45	28	33	17	4	2	15	18	6	0	0.898	1.000	1.000
453	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(1), ADCY8(3), ATF4(1), BRAF(1), CACNA1C(1), CALML3(1), CALML6(1), CREBBP(1), EP300(2), GRIA2(3), GRIN1(1), GRIN2B(2), GRIN2C(2), GRIN2D(1), GRM1(3), GRM5(1), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), PLCB1(3), PLCB3(1), PLCB4(1), PPP1CA(2), PPP1R12A(1), PPP3CB(1), PRKACA(1), PRKACB(1), PRKCG(1), RAPGEF3(1), RPS6KA1(1), RPS6KA6(1)	14091561	52	28	51	35	10	1	17	13	11	0	1.000	1.000	1.000
454	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALML3(1), CALML6(1), CDIPT(1), DGKB(1), DGKD(2), DGKH(1), DGKI(1), DGKZ(6), INPP4A(2), INPP5B(1), INPP5D(1), ITPR1(2), ITPR2(4), ITPR3(5), OCRL(1), PI4KA(4), PIK3C2G(1), PIK3C3(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PIP4K2B(1), PIP5K1C(1), PLCB1(3), PLCB3(1), PLCB4(1), PLCE1(2), PLCG1(3), PRKCG(1), SYNJ1(1)	17536808	57	27	55	35	10	1	22	18	6	0	1.000	1.000	1.000
455	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1(1), ACVR2B(1), AMH(1), AMHR2(1), BMP6(1), BMP8A(3), BMP8B(1), BMPR1A(2), BMPR1B(1), BMPR2(1), CHRD(2), CREBBP(1), DCN(2), EP300(2), GDF5(1), GDF6(1), ID1(1), INHBA(2), INHBB(3), LEFTY2(1), LTBP1(1), MAPK1(1), NOG(1), PITX2(3), PPP2R1B(1), RBL1(1), ROCK1(2), SMAD6(1), SMAD7(1), TFDP1(1), TGFBR2(2), THBS1(1), THBS2(2), THBS4(2), ZFYVE16(1), ZFYVE9(3)	13481802	53	27	51	30	15	2	22	13	1	0	0.993	1.000	1.000
456	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	BCAR1(1), CAPN2(3), CAPN6(4), CAPN9(1), CAPNS1(1), CSK(1), DOCK1(2), ITGA10(2), ITGA2(1), ITGA2B(1), ITGA3(2), ITGA4(1), ITGA6(1), ITGA9(1), ITGAE(1), ITGAL(1), ITGAM(2), ITGAX(1), ITGB4(1), ITGB5(1), ITGB6(1), ITGB8(2), MAP2K3(2), MAPK7(2), MYLK2(2), PAK3(3), PAK4(1), PIK3R2(1), RAPGEF1(1), ROCK1(2), SHC3(1), SORBS1(1), TLN1(2), TNS1(3), VASP(1), VAV2(1), VAV3(3), ZYX(1)	18864789	59	27	58	22	8	0	34	10	6	1	0.778	1.000	1.000
457	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	ALG10(1), ALG13(3), ALG2(2), ALG3(1), ALG6(1), B3GNT6(4), B4GALT5(2), B4GALT7(1), C1GALT1(1), CHPF(2), CHST11(1), CHST13(3), CHST3(1), EXT1(1), GALNT10(1), GALNT12(2), GALNT14(1), GALNT3(2), GALNT4(1), GALNT5(1), GALNT8(2), HS3ST2(3), HS3ST3A1(2), HS3ST5(2), HS6ST1(1), HS6ST2(1), MAN2A1(1), MGAT3(1), NDST2(1), NDST4(2), OGT(1), RPN2(2), ST3GAL1(1), ST6GALNAC1(1), XYLT1(1)	15206156	54	26	50	26	6	4	19	13	12	0	0.985	1.000	1.000
458	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(2), ACACB(4), BRAF(1), CALML3(1), CALML6(1), CBL(1), CBLC(1), FASN(3), G6PC2(1), INPP5D(1), INSR(1), IRS4(1), LIPE(2), MAPK1(1), MKNK1(1), PCK1(1), PDE3A(2), PDE3B(1), PFKL(2), PHKA2(2), PHKB(3), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PPARGC1A(2), PPP1CA(2), PPP1R3A(1), PRKAA2(1), PRKACA(1), PRKACB(1), PRKAG2(3), PRKAG3(1), PRKAR1A(7), PRKCI(1), PTPRF(2), PYGL(1), RAPGEF1(1), SHC2(2), SHC3(1), SORBS1(1), SOS2(1), TSC2(1)	22419003	70	26	69	39	14	3	17	16	20	0	1.000	1.000	1.000
459	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ATM(5), ATR(3), CDKN2A(2), HDAC1(1), RB1(2), TFDP1(1), TP53(18)	4063077	32	25	32	10	4	0	8	2	17	1	0.878	1.000	1.000
460	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA12(3), ABCA13(2), ABCA2(2), ABCA3(1), ABCA5(2), ABCA6(3), ABCA7(2), ABCB1(1), ABCB11(1), ABCB4(2), ABCB5(1), ABCC1(1), ABCC10(1), ABCC11(4), ABCC12(1), ABCC2(2), ABCC3(2), ABCC5(1), ABCC6(2), ABCC9(1), ABCD1(1), ABCD2(1), ABCD4(1), ABCG5(1), CFTR(2), TAP1(1), TAP2(1)	16469235	43	25	43	45	7	2	18	6	10	0	1.000	1.000	1.000
461	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	BDKRB2(1), C1QC(1), C1S(1), C2(1), C3AR1(1), C6(1), C7(1), C8B(1), C9(3), CFB(1), CFD(1), CFH(2), CR1(1), CR2(2), F13A1(1), F5(2), F8(2), F9(1), KNG1(1), PLAT(1), PLG(1), PROC(1), PROS1(1), SERPINA1(1), SERPIND1(1), SERPINE1(1), SERPING1(1), TFPI(1), VWF(6)	12458659	40	25	40	17	9	2	13	10	6	0	0.861	1.000	1.000
462	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(5), ATR(3), CHEK2(2), EP300(2), MDM2(2), PRKDC(3), RPS6KA1(1), TP53(18)	5842035	36	24	36	17	3	0	10	3	19	1	0.996	1.000	1.000
463	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	99	CASP8(1), CD14(1), CXCL9(2), FADD(2), IFNA8(1), IFNAR2(1), IRAK1(2), IRF3(1), IRF5(1), LBP(1), MAP2K3(2), MAP3K8(1), MAPK1(1), MAPK11(1), NFKB1(1), NFKB2(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), TICAM1(1), TLR2(2), TLR4(3), TLR6(1), TLR7(1), TLR9(2)	12276388	37	24	36	38	4	3	14	10	6	0	1.000	1.000	1.000
464	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTN2(2), ACTN4(1), DMD(4), MYBPC1(1), MYBPC2(1), MYH3(2), MYH6(4), MYH7(1), MYH8(4), MYL1(1), MYOM1(1), NEB(7), TNNT1(1), TNNT2(1), TPM2(2), TTN(26), VIM(1)	19079615	60	24	60	24	8	7	25	13	7	0	0.917	1.000	1.000
465	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	CAD(1), DHODH(3), DPYD(2), DPYS(2), ENTPD4(3), ENTPD8(1), NME6(1), NT5C1A(1), NT5C1B(2), NT5E(1), NT5M(1), NUDT2(1), POLA2(1), POLD1(2), POLD2(1), POLE(3), POLR1A(1), POLR1C(2), POLR2B(2), POLR2H(1), RFC5(1), RRM2(1), UCK2(1)	11282709	35	23	33	14	6	4	14	5	6	0	0.881	1.000	1.000
466	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	AMDHD1(18), AOC3(1), LCMT1(1), MAOA(3), UROC1(1), WBSCR22(1)	5514870	25	23	8	22	1	1	3	18	2	0	1.000	1.000	1.000
467	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	93	CARD11(3), CBL(1), CBLC(1), CD247(1), CD3D(1), CD8A(1), CTLA4(2), IL2(1), ITK(1), LAT(1), LCK(1), MAP3K8(1), NCK2(1), NFATC1(1), NFKB1(1), NFKB2(1), NFKBIE(2), PAK3(3), PAK4(1), PAK7(2), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PLCG1(3), PPP3CB(1), PRKCQ(2), PTPN6(1), RASGRP1(2), SOS2(1), TEC(1), VAV1(3), VAV2(1), VAV3(3), ZAP70(1)	13957564	53	23	53	43	8	3	23	8	11	0	1.000	1.000	1.000
468	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	71	ACACB(4), ACSL1(3), ACSL3(2), ADIPOR1(1), CAMKK2(1), CPT1C(1), G6PC2(1), IRS4(1), JAK1(1), JAK2(2), JAK3(3), LEPR(2), NFKB1(1), NFKB2(1), NFKBIE(2), PCK1(1), PPARA(1), PPARGC1A(2), PRKAA2(1), PRKAG2(3), PRKAG3(1), PRKCQ(2), PTPN11(1), STK11(2), TNFRSF1A(1), TYK2(2)	11522828	43	23	43	44	5	3	18	8	9	0	1.000	1.000	1.000
469	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP6V0A1(2), ATP6V0A4(1), ATP6V0C(1), ATP6V1A(1), ATP7B(3), COX4I1(1), COX6B1(1), COX7A1(1), NDUFA1(1), NDUFA10(2), NDUFB5(2), NDUFB7(1), NDUFS2(1), SDHA(1), SDHB(1), UQCRFS1(12)	5228982	32	23	21	15	3	0	11	15	3	0	0.963	1.000	1.000
470	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ARHGAP4(1), ARHGEF11(2), BTK(1), ITPR1(2), ITPR2(4), ITPR3(5), MYLK(2), MYLK2(2), PAK3(3), PAK4(1), PAK7(2), PIK3CA(1), PIK3R1(1), PITX2(3), ROCK1(2)	9656099	32	23	32	20	5	0	15	8	4	0	0.993	1.000	1.000
471	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ACTN1(2), BCAR1(1), BRAF(1), CDKN2A(2), DOCK1(2), ITGA10(2), ITGA2(1), ITGA3(2), ITGA4(1), ITGA6(1), ITGA9(1), MAPK1(1), MAPK8IP3(2), MYLK(2), MYLK2(2), P4HB(1), PAK3(3), PAK4(1), PAK7(2), PIK3CA(1), PIK3CB(1), PLCG1(3), ROCK1(2), SOS2(1), TLN1(2), TLN2(6), VASP(1), WAS(1), ZYX(1)	16951981	49	23	49	18	6	1	26	8	7	1	0.800	1.000	1.000
472	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	DNAJA3(1), JAK2(2), NFKB1(1), RB1(2), TNFRSF1A(1), TP53(18), USH1C(2), WT1(2)	2514174	29	23	29	14	4	1	8	3	12	1	0.967	1.000	1.000
473	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(1), AKR1D1(1), ARSD(2), CYP11B1(1), CYP11B2(1), HSD11B1(1), HSD17B1(5), HSD17B7(2), LCMT1(1), STS(1), UGT1A3(1), UGT1A5(2), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B15(2), UGT2B28(1), WBSCR22(1)	6815004	30	22	25	26	8	1	18	2	1	0	1.000	1.000	1.000
474	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL2(1), AREG(1), BRAF(1), CBL(1), CBLC(1), EGFR(3), ERBB3(1), ERBB4(5), GAB1(1), MAPK1(1), NCK2(1), NRG2(2), NRG3(2), PAK3(3), PAK4(1), PAK7(2), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PLCG1(3), PRKCG(1), SHC2(2), SHC3(1), SOS2(1), STAT5B(1)	14258983	43	22	42	19	10	3	14	8	8	0	0.944	1.000	1.000
475	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CLK2(1), COL2A1(1), CPSF1(2), CPSF3(1), CSTF2(1), DHX15(1), DHX38(1), DICER1(1), GIPC1(1), NCBP1(1), NXF1(1), PAPOLA(2), PRPF4B(1), PRPF8(2), PTBP2(1), RBM5(1), SF3B1(2), SNRPB2(1), SNRPE(1), SNRPN(1), SNURF(1), SRPK1(1), SRPK2(1), SRRM1(3), SUPT5H(1), U2AF1(1)	14559938	32	22	32	12	7	1	12	4	7	1	0.925	1.000	1.000
476	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(1), APAF1(1), BAG4(1), CASP8(1), DAXX(4), DFFA(1), FADD(2), GSN(1), LMNB1(1), LMNB2(2), MAP3K1(2), MDM2(2), NFKB1(1), NUMA1(1), PRKDC(3), RB1(2), SPTAN1(3), TNFRSF1A(1)	9626726	30	21	30	14	8	3	6	0	13	0	0.945	1.000	1.000
477	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP6(1), BMP8A(3), BMP8B(1), DHH(2), GLI2(2), GLI3(9), HHIP(2), LRP2(2), PRKACA(1), PRKACB(1), PTCH1(2), SHH(2), SMO(3), SUFU(1), WNT1(2), WNT10A(1), WNT16(1), WNT2(1), WNT2B(1), WNT3(1), WNT4(1), WNT6(1)	8249861	41	21	33	16	14	3	10	6	7	1	0.815	1.000	1.000
478	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	85	BRAF(1), DAXX(4), MAP2K3(2), MAP3K1(2), MAP3K12(1), MAP3K13(1), MAP3K3(1), MAP3K4(1), MAP3K8(1), MAP4K3(1), MAP4K4(1), MAPK1(1), MAPK11(1), MAPK7(2), MEF2C(2), MKNK1(1), NFKB1(1), RPS6KA1(1), RPS6KA4(2)	13569839	27	21	26	25	6	1	9	7	4	0	1.000	1.000	1.000
479	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(1), DHODH(3), DPYD(2), DPYS(2), NT5E(1), NT5M(1), NUDT2(1), POLD1(2), POLD2(1), POLE(3), POLG(1), POLQ(1), POLR2B(2), POLR2H(1), POLRMT(5), RRM2(1), UCK2(1)	7970231	29	21	25	11	5	7	9	4	4	0	0.850	1.000	1.000
480	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	BCR(2), BTK(1), CD19(2), CDKN2A(2), DAPP1(1), GAB1(1), ITPR1(2), ITPR2(4), ITPR3(5), PIK3CA(1), PITX2(3), PREX1(4), RPS6KA1(1), SYK(1), TEC(1), VAV1(3)	7642083	34	21	34	20	6	2	16	6	4	0	0.995	1.000	1.000
481	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	CKM(2), CKMT2(1), CPS1(3), DAO(1), EPRS(3), GLUD1(1), GLUD2(1), GOT1(1), GOT2(2), LAP3(1), NOS1(2), NOS3(4), PRODH(4), PYCRL(1), RARS2(2)	4978875	29	20	28	19	5	2	11	7	4	0	0.994	1.000	1.000
482	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	70	ADH6(1), ADH7(2), AKR1C3(1), AKR1C4(1), CYP2B6(3), CYP2C9(1), DHDH(1), EPHX1(1), GSTA2(1), GSTK1(1), GSTO2(1), GSTP1(1), GSTT2(2), MGST1(1), UGT1A3(1), UGT1A5(2), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B15(2), UGT2B28(1)	7872971	31	20	30	16	5	0	15	5	6	0	0.975	1.000	1.000
483	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACSL1(3), ACSL3(2), ANGPTL4(1), AQP7(4), CPT1C(1), CYP4A22(4), EHHADH(1), FABP2(1), FADS2(1), GK2(1), HMGCS2(1), PCK1(1), PPARA(1), SLC27A1(3), SLC27A5(1), SORBS1(1)	8901470	27	20	25	11	5	3	10	6	3	0	0.822	1.000	1.000
484	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH6(1), ADH7(2), AGK(1), AKR1A1(1), CEL(1), DGKB(1), DGKD(2), DGKH(1), DGKI(1), DGKZ(6), GK2(1), GPAM(2), LCT(1), PNLIP(3), PNLIPRP1(2), PNPLA3(2), PPAP2C(1)	8204393	29	19	27	13	4	0	12	8	5	0	0.914	1.000	1.000
485	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(2), AR(2), ESR1(1), HNF4A(1), NR1D1(1), NR1H2(2), NR2C2(1), NR2F1(3), NR4A2(2), NR5A1(2), NR5A2(1), PGR(1), PPARA(1), RARA(1), RORA(1), RORC(2), THRA(1), VDR(1)	5866536	26	19	26	19	3	2	8	5	7	1	1.000	1.000	1.000
486	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(1), AOC3(1), CKM(2), CKMT2(1), CPS1(3), DAO(1), GLUD1(1), GOT1(1), GOT2(2), MAOA(3), NOS1(2), NOS3(4), P4HB(1)	6107961	23	18	23	26	4	1	10	3	5	0	1.000	1.000	1.000
487	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	BCR(2), BTK(1), CD19(2), CR2(2), CSK(1), INPP5D(1), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), NFATC1(1), PIK3CA(1), PIK3R1(1), PPP3CB(1), SOS2(1), SYK(1), VAV1(3)	10092849	30	18	30	14	4	0	12	8	6	0	0.944	1.000	1.000
488	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(1), TP53(18), WT1(2)	967489	21	18	21	13	3	0	6	1	10	1	0.993	1.000	1.000
489	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ALG6(1), CCR3(1), CELSR1(3), CELSR2(1), CXCR3(2), EMR2(4), EMR3(1), FSHR(1), GPR133(1), GPR61(2), GPR84(2), GRM1(3), LGR6(2), LPHN2(1), LPHN3(3), SMO(3), SSTR2(1), TAAR5(3)	9163804	35	17	34	17	6	2	17	8	2	0	0.883	1.000	1.000
490	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	INPP4A(2), INPP5B(1), IPMK(1), OCRL(1), PI4KA(4), PIK3C3(1), PIK3CA(1), PIK3CB(1), PIP4K2B(1), PIP5K1C(1), PLCB1(3), PLCB3(1), PLCB4(1), PLCE1(2), PLCG1(3), SYNJ1(1)	10340170	25	17	25	26	6	1	10	6	2	0	1.000	1.000	1.000
491	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	ERCC3(1), POLR1A(1), POLR2B(2), POLR2H(1), TAF5(12)	4741344	17	17	6	12	0	0	3	12	2	0	0.998	1.000	1.000
492	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(1), FLNA(3), FLNC(1), MYH2(2), MYLK(2), MYLK2(2), PAK3(3), PAK4(1), PAK7(2), ROCK1(2), VASP(1)	6599267	20	17	20	12	3	2	8	4	3	0	0.946	1.000	1.000
493	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(1), CD3D(1), CSK(1), CTLA4(2), ITK(1), LAT(1), LCK(1), MAPK1(1), NFKB1(1), NFKB2(1), NFKBIE(2), PAK3(3), PAK4(1), PAK7(2), PLCG1(3), RASGRP1(2), SOS2(1), VAV1(3), ZAP70(1)	7855491	29	17	29	33	5	1	13	3	7	0	1.000	1.000	1.000
494	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(2), GAA(1), HK2(3), HK3(3), MGAM(4), PYGL(1), SI(5), UGT1A3(1), UGT1A5(2), UGT2B15(2)	7870820	24	17	24	12	2	0	12	6	4	0	0.946	1.000	1.000
495	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	CREBBP(1), EP300(2), ERCC3(1), ESR1(1), GRIP1(3), HDAC1(1), HDAC2(1), HDAC4(1), HDAC6(2), MEF2C(2), NCOR2(4), NRIP1(3), PELP1(1)	6521150	23	16	23	22	0	0	12	6	5	0	1.000	1.000	1.000
496	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP5(1), ACPP(1), ALPI(1), ALPP(1), ALPPL2(8), CYP2A6(1), CYP2B6(3), CYP2C9(1), CYP2J2(1), CYP4B1(1), PON1(1)	4022990	20	16	14	9	1	9	8	2	0	0	0.817	1.000	1.000
497	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(1), AGPS(1), CDIPT(1), CHAT(1), CHKB(1), DGKB(1), DGKD(2), DGKH(1), DGKZ(6), GNPAT(1), PCYT1B(1), PEMT(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLCG1(3), PPAP2C(1)	7076651	29	16	27	11	5	1	13	6	4	0	0.782	1.000	1.000
498	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ENO2(1), ENO3(1), GOT1(1), GOT2(2), HK2(3), HK3(3), LDHA(3), MDH2(1), PC(1), PCK1(1), PDHB(1), PFKL(2), PGAM1(1), PGK2(3)	5761728	24	16	24	10	5	1	10	6	2	0	0.776	1.000	1.000
499	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	FUK(3), GMPPB(1), HK2(3), HK3(3), KHK(2), LHPP(2), MTMR1(1), MTMR2(1), PFKL(2)	5226583	18	16	17	11	5	3	6	2	2	0	0.943	1.000	1.000
500	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	66	ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0C(1), ATP6V0D2(1), ATP6V1A(1), ATP6V1E2(1), CSK(1), CXCL1(1), EGFR(3), F11R(2), GIT1(1), MAPK11(1), NFKB1(1), NFKB2(1), NOD1(1), PLCG1(3), PTPN11(1), PTPRZ1(2), TCIRG1(1), TJP1(1)	9721091	29	16	29	29	5	0	12	4	8	0	1.000	1.000	1.000
501	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	BRAF(1), EGFR(3), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), PIK3CB(1), PITX2(3), PLCB1(3), PLCB3(1), PLCB4(1), SOS2(1)	8020097	26	16	26	15	6	1	10	8	1	0	0.965	1.000	1.000
502	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	27	ITPR1(2), ITPR2(4), ITPR3(5), NFKB1(1), NFKB2(1), NFKBIE(2), PHKA2(2), PIK3CB(1), PITX2(3), PLD2(1)	6322591	22	16	22	30	3	1	13	5	0	0	1.000	1.000	1.000
503	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH6(1), ADH7(2), AKR1A1(1), CEL(1), DGKB(1), DGKD(2), DGKH(1), DGKZ(6), LCT(1), PNLIP(3), PNLIPRP1(2), PPAP2C(1)	6767103	22	15	20	10	3	0	9	7	3	0	0.925	1.000	1.000
504	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS2(1), ADH6(1), ADH7(2), AKR1A1(1), ENO2(1), ENO3(1), G6PC2(1), HK2(3), HK3(3), LDHA(3), PDHB(1), PFKL(2), PGAM1(1), PGK2(3)	7949915	24	15	24	15	4	1	8	8	3	0	0.987	1.000	1.000
505	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	KDR(1), MAPK1(1), MAPK11(1), NFATC1(1), NOS3(4), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLCG1(3), PPP3CB(1), PRKCG(1), PTGS2(1), SH2D2A(1), SHC2(2), SPHK1(2), SPHK2(2)	10029602	35	15	35	12	6	2	13	8	6	0	0.774	1.000	1.000
506	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ADCY1(1), GNAS(5), GNB1(2), MAPK1(1), PIN1(1), PRKACB(1), PRKAR1A(7), RPS6KA1(1)	2869292	19	15	18	11	2	0	4	3	10	0	0.998	1.000	1.000
507	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(8), B3GALT4(1), CDR1(1), DGKI(1), RPL12(1), RPL13A(1), RPL14(1), RPL22(1), RPL39(1), RPS21(1), RPS24(1), RPS3(1), RPS6KA1(1), RPS6KA6(1), RPS9(1), SLC36A2(1), UBB(1)	7078619	24	15	24	29	3	0	14	4	3	0	1.000	1.000	1.000
508	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	APC(4), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), PITX2(3), PTX3(1), RYR1(4)	6422087	24	15	24	14	4	0	11	7	2	0	0.965	1.000	1.000
509	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(1), GNAS(5), MAPK1(1), PIK3CA(1), PIK3R1(1), PRKACB(1), PRKAR1A(7), RPS6KA1(1)	4020793	18	14	17	12	1	0	3	4	10	0	0.999	1.000	1.000
510	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASDHPPT(1), DLST(1), DOT1L(2), ECHS1(2), EHHADH(1), EHMT1(3), EHMT2(1), HADH(1), HADHA(1), HSD17B4(3), NSD1(3), OGDHL(1), PIPOX(1), PLOD3(2), SETD1A(1), SETDB1(1), SHMT2(1)	7928148	26	14	26	11	4	1	13	2	6	0	0.853	1.000	1.000
511	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	73	BTK(1), FCER1A(2), IL3(1), INPP5D(1), LAT(1), MAP2K3(2), MAPK1(1), MAPK11(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLCG1(3), SOS2(1), SYK(1), VAV1(3), VAV2(1), VAV3(3)	9780118	36	14	36	14	5	1	12	9	9	0	0.908	1.000	1.000
512	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(5), CASP8(1), INSR(1), ITCH(1), MAGI1(2), MAGI2(4), RERE(2), WWP1(1), WWP2(1)	3231733	18	14	15	10	2	0	13	2	1	0	0.967	1.000	1.000
513	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	BCL2L1(2), CDKN2A(2), ERBB4(5), GAB1(1), IGFBP1(1), IRS4(1), PAK3(3), PAK4(1), PAK7(2), PARD3(1), PIK3CA(1), PREX1(4), RPS6KA1(1), SOS2(1), TSC2(1)	10492334	27	14	27	30	4	2	12	3	6	0	1.000	1.000	1.000
514	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	BRAF(1), CREBBP(1), EGR1(2), EGR2(1), EGR3(1), EGR4(3), MAP1B(2), MAPK1(1), MAPK8IP3(2), NTRK1(1), PIK3C2G(1), PIK3CA(1), PIK3R1(1), PTPN11(1), TH(3)	7218048	22	14	22	10	5	0	9	6	2	0	0.870	1.000	1.000
515	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(3), GNAS(5), GNB1(2), IGF1R(1), MAPK1(1), MKNK1(1), NGFR(2), PDGFRA(1), RPS6KA1(1)	4630830	17	13	17	14	7	0	5	3	2	0	0.998	1.000	1.000
516	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH6(1), ADH7(2), AKR1A1(1), ENO2(1), ENO3(1), HK2(3), HK3(3), LDHA(3), PDHB(1), PGAM1(1)	6649636	17	13	17	12	3	1	6	5	2	0	0.986	1.000	1.000
517	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH6(1), ADH7(2), AKR1A1(1), ENO2(1), ENO3(1), HK2(3), HK3(3), LDHA(3), PDHB(1), PGAM1(1)	6649636	17	13	17	12	3	1	6	5	2	0	0.986	1.000	1.000
518	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	DHCR24(2), DHCR7(1), FDFT1(1), HMGCR(1), HSD17B7(2), IDI1(5), NSDHL(1), SQLE(2)	2698903	15	13	12	20	1	1	10	1	2	0	1.000	1.000	1.000
519	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	INPP4A(2), OCRL(1), PIK3C2G(1), PIK3CA(1), PIK3CB(1), PLCB1(3), PLCB3(1), PLCB4(1), PLCG1(3)	6231922	14	13	14	18	3	1	5	5	0	0	1.000	1.000	1.000
520	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	FPR1(2), GNB1(2), MAP2K3(2), MAP3K1(2), MAPK1(1), NFATC1(1), NFKB1(1), PIK3C2G(1), PLCB1(3), PPP3CB(1)	5343247	16	12	16	7	2	0	11	3	0	0	0.824	1.000	1.000
521	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(2), ARSD(2), DEGS2(1), GAL3ST1(1), GALC(1), LCT(1), PPAP2C(1), SGPP1(1), SMPD4(1), SPHK1(2), SPHK2(2), SPTLC1(1), SPTLC2(1)	4904800	17	12	17	10	3	0	11	1	2	0	0.944	1.000	1.000
522	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	63	BTK(1), CARD11(3), CD19(2), CR2(2), INPP5D(1), NFATC1(1), NFKB1(1), NFKB2(1), NFKBIE(2), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PPP3CB(1), PTPN6(1), SYK(1), VAV1(3), VAV2(1), VAV3(3)	10267179	31	12	31	36	3	1	14	6	7	0	1.000	1.000	1.000
523	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP4(1), ARHGAP6(2), ARHGEF1(1), ARHGEF11(2), ARHGEF5(2), ARPC2(1), GSN(1), MYLK(2), ROCK1(2), TLN1(2)	6410134	16	12	16	12	3	1	7	3	2	0	0.992	1.000	1.000
524	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	BRD4(1), CBL(1), CDKN2A(2), IGFBP1(1), IRS4(1), LNPEP(1), MAPK1(1), PARD3(1), PIK3CA(1), PIK3R1(1), PPYR1(3), RPS6KA1(1), SORBS1(1), SOS2(1)	8012878	17	12	17	24	3	1	8	2	3	0	1.000	1.000	1.000
525	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	35	ARHGEF11(2), LPA(1), MAP3K1(2), NFKB1(1), NFKB2(1), NFKBIE(2), PHKA2(2), PIK3CB(1), PLD2(1), ROCK1(2), SERPINA4(1), SRF(1), TBXA2R(1)	6701222	18	12	18	32	4	1	11	2	0	0	1.000	1.000	1.000
526	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	MAPK1(1), MAPK7(2), MEF2C(2), NTRK1(1), PIK3CA(1), PIK3R1(1), PLCG1(3), RPS6KA1(1)	2716219	12	11	11	10	2	0	7	3	0	0	0.996	1.000	1.000
527	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	BRAF(1), MAPK1(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PRKAA2(1), RPS6KA1(1), RPS6KA6(1), STK11(2), TSC2(1), ULK1(1), ULK2(1), ULK3(1), VEGFB(1)	7379172	19	11	19	15	0	2	7	5	5	0	1.000	1.000	1.000
528	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	DAXX(4), MAP3K1(2), MEF2C(2), MKNK1(1), PLA2G4A(3)	5110395	12	11	12	11	2	1	4	2	3	0	0.999	1.000	1.000
529	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	BCR(2), BTK(1), CD19(2), CSK(1), MAPK1(1), NFKB1(1), NFKB2(1), NFKBIE(2), PIK3CA(1), PIK3R1(1), SERPINA4(1), SOS2(1), SYK(1), VAV1(3)	7283022	19	11	19	33	2	0	10	3	4	0	1.000	1.000	1.000
530	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	28	BAG4(1), CASP8(1), FADD(2), MAP3K3(1), NFKB1(1), NFKB2(1), NFKBIE(2), NR2C2(1), TNFRSF1A(1)	3813055	11	11	11	28	2	1	6	0	2	0	1.000	1.000	1.000
531	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), AKR1D1(1), ARSD(2), CYP11B1(1), CYP11B2(1), HSD11B1(1), STS(1), UGT1A3(1), UGT1A5(2), UGT2B15(2)	3695827	13	10	13	21	2	0	8	2	1	0	1.000	1.000	1.000
532	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	EGFR(3), JAK1(1), MAP3K1(2), PIK3CA(1), PIK3R1(1), PLCG1(3), SRF(1)	5087679	12	10	12	6	6	0	5	1	0	0	0.847	1.000	1.000
533	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	29	CABIN1(1), IGF1R(1), INSR(1), MAPK7(2), MEF2C(2), NFATC1(1), PIK3CA(1), PIK3R1(1), PPP3CB(1)	4781674	11	10	10	6	2	0	6	3	0	0	0.877	1.000	1.000
534	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	CTH(1), DNMT3B(1), MARS(1), MARS2(1), MTAP(1), MTFMT(4), MTR(1), SRM(1)	2870791	11	10	9	16	2	1	1	6	1	0	1.000	1.000	1.000
535	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	BCR(2), MAP3K1(2), MAPK1(1), MAPK8IP3(2), PAPPA(5), RPS6KA1(1), SYK(1), VAV1(3), VAV2(1), VAV3(3)	4424463	21	10	21	13	3	0	12	2	4	0	0.991	1.000	1.000
536	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	GNB1(2), JAK2(2), MAPK1(1), MYLK(2), PLCG1(3)	5776211	10	9	10	7	2	0	5	3	0	0	0.972	1.000	1.000
537	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	AGMAT(1), ALDH18A1(2), AOC3(1), CPS1(3), MAOA(3), SAT1(2), SRM(1)	4078215	13	9	13	20	1	0	7	0	5	0	1.000	1.000	1.000
538	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	IL1RN(2), IRAK1(2), IRAK2(2), MAP2K3(2), MAP3K1(2), NFKB1(1)	4046748	11	9	10	8	3	0	5	3	0	0	0.981	1.000	1.000
539	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA2A(2), ADRA2C(4), CHRM5(1), DRD3(1), DRD5(1), HTR2A(1), HTR2C(1), HTR5A(3), HTR6(1)	3518070	15	9	14	10	3	2	5	3	2	0	0.941	1.000	1.000
540	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGEF1(1), GNB1(2), MYLK(2), PLCB1(3), ROCK1(2)	2790669	10	9	10	5	1	0	8	1	0	0	0.882	1.000	1.000
541	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(1), ARHGEF1(1), GNB1(2), PIK3CA(1), PIK3R1(1), PLCB1(3), ROCK1(2)	3489296	11	9	11	6	1	0	7	3	0	0	0.925	1.000	1.000
542	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	28	ANXA1(1), ANXA5(1), EDNRB(1), HSD11B1(1), PLA2G4A(3), PTGDS(1), PTGER4(1), PTGIR(1), PTGS1(1), PTGS2(1)	2850106	12	9	12	29	1	0	6	3	2	0	1.000	1.000	1.000
543	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	INSR(1), JAK2(2), MAPK1(1), PIK3CA(1), PIK3R1(1), PLCG1(3), PTPN6(1), RPS6KA1(1), SRF(1), STAT5B(1)	4517348	13	8	13	14	4	0	3	4	2	0	1.000	1.000	1.000
544	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ADH6(1), ADH7(2), AKR1C4(1), AKR1D1(1), BAAT(1), CEL(1), HADHB(1), SLC27A5(1), SOAT2(1)	4376885	10	8	10	29	3	0	4	2	1	0	1.000	1.000	1.000
545	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	AOC3(1), DPYD(2), DPYS(2), ECHS1(2), EHHADH(1), HADHA(1), SRM(1)	3659600	10	8	10	13	2	0	5	0	3	0	1.000	1.000	1.000
546	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	JAK1(1), MAP3K1(2), PDGFRA(1), PIK3CA(1), PIK3R1(1), PLCG1(3), SRF(1)	4754969	10	8	10	7	4	0	4	2	0	0	0.956	1.000	1.000
547	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	IL4R(1), JAK1(1), JAK3(3), MAPK1(1), PIK3CA(1), PIK3R1(1), SOS2(1), STAT6(1)	4977591	10	8	10	11	1	1	3	4	1	0	0.999	1.000	1.000
548	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	DUSP1(1), MAP2K3(2), MAP3K4(1), MAPK1(1), MAPK11(1), MKNK1(1), MYEF2(1), NFKB1(1), NR2C2(1), SRF(1)	4673938	11	8	11	11	3	0	5	3	0	0	0.998	1.000	1.000
549	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(1), ARFGEF2(2), CLTB(3), COPA(1), GPLD1(1)	2212391	8	7	8	5	2	1	4	1	0	0	0.911	1.000	1.000
550	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	EGFR(3), MAP3K1(2), MAPK1(1), MEF2C(2)	4654717	8	7	8	6	3	0	3	2	0	0	0.944	1.000	1.000
551	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ADH6(1), ADH7(2), AKR1C4(1), AKR1D1(1), BAAT(1), CEL(1), HADHB(1), SOAT2(1)	3161818	9	7	9	24	3	0	3	2	1	0	1.000	1.000	1.000
552	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(1), ETS2(1), HDAC2(1), NCOR2(4), RBL1(1), SIN3B(2)	3711836	10	7	10	10	3	0	3	3	1	0	0.996	1.000	1.000
553	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	GABRA1(2), GABRA2(2), GABRA6(2), UBQLN1(1)	1648217	7	7	7	4	0	0	6	1	0	0	0.912	1.000	1.000
554	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACO1(1), CS(1), DLST(1), FH(1), IDH3G(1), MDH2(1), OGDHL(1), PC(1), PCK1(1), SDHA(1), SDHB(1), SDHD(1)	4076526	12	7	12	8	1	1	7	3	0	0	0.954	1.000	1.000
555	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	G6PD(2), PFKL(2), PRPS1L1(1), RPIA(1), TKTL2(3)	3351359	9	7	8	22	3	2	2	2	0	0	1.000	1.000	1.000
556	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT2(1), B4GALT7(1), CHPF(2), CHST11(1), CHST13(3), CHST3(1), DSE(2), XYLT1(1)	1954195	12	7	11	7	1	3	4	4	0	0	0.907	1.000	1.000
557	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	CS(1), DLST(1), FH(1), IDH3G(1), MDH2(1), PC(1), PDHB(1), PDK3(1), SDHA(1), SDHB(1), SDHD(1)	3897773	11	7	11	6	0	1	7	3	0	0	0.902	1.000	1.000
558	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	NGFR(2), PIK3CA(1), PIK3R1(1), PLCG1(3)	2593175	7	7	7	4	4	0	2	1	0	0	0.880	1.000	1.000
559	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(1), NCOA1(2), NCOA2(1), NCOR2(4), RARA(1)	3459263	9	7	9	18	0	0	4	3	2	0	1.000	1.000	1.000
560	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(1), PDE1A(2), PLCB1(3), TRH(1), VIP(1)	1512421	8	7	8	8	1	1	3	3	0	0	0.994	1.000	1.000
561	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	33	DUSP1(1), MAPK1(1), MAPK11(1), MAPK8IP3(2), NFKB1(1), NFKB2(1), NFKBIE(2), PIK3CA(1), PIK3R1(1)	4851854	11	7	11	26	0	0	8	3	0	0	1.000	1.000	1.000
562	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BRAF(1), DUSP6(1), MAP3K8(1), MAPK1(1), MKNK1(1), NFKB1(1), RPS6KA1(1), SOS2(1)	4108355	8	7	8	13	2	0	2	3	1	0	1.000	1.000	1.000
563	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(1), BTK(1), CDKN2A(2), DAPP1(1), IARS(1), IGFBP1(1), INPP5D(1), PIK3CA(1), RPS6KA1(1), SOS2(1), TEC(1)	4858976	12	7	12	13	1	0	5	3	3	0	1.000	1.000	1.000
564	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	HLA-DRB1(3), IL18R1(2), IL2(1), IL4R(1)	1738503	7	7	7	4	0	1	5	1	0	0	0.889	1.000	1.000
565	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(2), CKM(2), CKMT2(1), CPS1(3), GLUD1(1)	2451275	9	7	9	17	1	0	4	2	2	0	1.000	1.000	1.000
566	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(2), EDNRB(1), EGFR(3), NFKB1(1), PLCG1(3)	2789316	10	6	10	5	5	1	4	0	0	0	0.786	1.000	1.000
567	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(1), CSF1R(1), EGFR(3), PDGFRA(1)	2658383	6	6	6	6	3	1	1	1	0	0	0.974	1.000	1.000
568	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPS7(1), RPL12(1), RPL13A(1), RPL14(1), RPL39(1), RPS21(1), RPS24(1), RPS3(1), RPS9(1)	2972477	9	6	9	18	1	0	5	2	1	0	1.000	1.000	1.000
569	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(1), JAK2(2), JAK3(3), PTPRU(1)	1927977	7	6	7	4	1	0	3	3	0	0	0.895	1.000	1.000
570	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	25	MAP2K3(2), MAP3K1(2), NFKB1(1), TANK(1), TNFRSF1A(1)	3355355	7	6	7	5	1	0	5	1	0	0	0.957	1.000	1.000
571	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	NTRK1(1), PIK3CA(1), PIK3R1(1), PLCG1(3)	2125976	6	6	6	4	2	0	3	1	0	0	0.936	1.000	1.000
572	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	NFATC1(1), PLCG1(3), PPP3CB(1)	2779525	5	5	5	3	2	0	3	0	0	0	0.850	1.000	1.000
573	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ADH6(1), ADH7(2), DHRS3(1), ESCO2(1), PNPLA3(2)	3336521	7	5	7	10	1	0	1	3	2	0	1.000	1.000	1.000
574	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	IGF1R(1), PIK3CA(1), PIK3R1(1), PTPN11(1), SRF(1)	3356010	5	5	5	5	2	0	1	2	0	0	0.984	1.000	1.000
575	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	HLA-DRB1(3), IL2(1), IL3(1)	1869697	5	5	5	8	0	0	4	1	0	0	0.999	1.000	1.000
576	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	INSR(1), PIK3CA(1), PIK3R1(1), PTPN11(1), SRF(1)	3461742	5	5	5	5	2	0	1	2	0	0	0.986	1.000	1.000
577	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	MST1(5)	892137	5	5	4	5	1	0	3	1	0	0	0.976	1.000	1.000
578	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	14	MTNR1A(2), MTNR1B(2), PTGER4(1), PTGIR(1), TBXA2R(1)	1574925	7	5	6	24	1	0	4	2	0	0	1.000	1.000	1.000
579	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(1), EGFR(3), MAPK1(1)	3402300	5	5	5	3	2	1	1	1	0	0	0.897	1.000	1.000
580	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHB1(1), L1CAM(1), SELP(2)	2136314	4	4	4	3	0	0	3	1	0	0	0.950	1.000	1.000
581	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP2A6(1), XDH(3)	1092359	4	4	4	4	0	0	4	0	0	0	0.981	1.000	1.000
582	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	IGF1R(1), MAPK1(1), PIK3CA(1), PIK3R1(1)	2550264	4	4	4	4	1	0	1	2	0	0	0.982	1.000	1.000
583	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(2), PLCG1(3)	921760	5	4	5	5	4	0	1	0	0	0	0.955	1.000	1.000
584	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSS(1), IMPDH1(1), OAZ1(1), POLD1(2), POLG(1), SRM(1)	1800831	7	4	7	10	1	0	5	0	1	0	1.000	1.000	1.000
585	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	G6PD(2), PRPS1L1(1), RPIA(1)	2761858	4	4	4	21	1	1	1	1	0	0	1.000	1.000	1.000
586	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	BCAR1(1), MAPK1(1), PIK3CA(1), PIK3R1(1)	2623376	4	4	4	3	0	0	2	2	0	0	0.952	1.000	1.000
587	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	FCGR3A(3), IL6R(1), TNFRSF1A(1)	1913999	5	4	5	5	0	0	5	0	0	0	0.977	1.000	1.000
588	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	IGF1R(1), PIK3CA(1), PIK3R1(1)	1799971	3	3	3	9	1	0	1	1	0	0	1.000	1.000	1.000
589	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	MEF2C(2), PPARA(1), PPP3CB(1)	2914713	4	3	4	4	0	0	2	2	0	0	0.972	1.000	1.000
590	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD8A(1), EPO(1), IL2(1), IL3(1)	856121	4	3	4	3	0	1	3	0	0	0	0.882	1.000	1.000
591	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IL2(1), IL3(1)	1342021	2	2	2	2	0	0	2	0	0	0	0.952	1.000	1.000
592	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	EPO(1), IL3(1)	1168926	2	2	2	3	0	0	2	0	0	0	0.990	1.000	1.000
593	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	CS(1), FH(1), SDHA(1)	1287672	3	2	3	3	0	0	3	0	0	0	0.955	1.000	1.000
594	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	CS(1), PC(1)	1270925	2	2	2	2	0	0	1	1	0	0	0.946	1.000	1.000
595	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CSK(1), PTPRA(1)	1275506	2	2	2	2	0	0	2	0	0	0	0.942	1.000	1.000
596	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	UBE2S(1), UBE3A(1)	1422278	2	2	2	2	0	0	1	1	0	0	0.969	1.000	1.000
597	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(1)	736961	1	1	1	3	0	0	1	0	0	0	0.995	1.000	1.000
598	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	IL2(1)	416620	1	1	1	2	0	0	1	0	0	0	0.991	1.000	1.000
599	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	LDLR(1)	720336	1	1	1	3	0	0	1	0	0	0	0.994	1.000	1.000
600	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	P2RY2(2)	788822	2	1	2	3	2	0	0	0	0	0	0.951	1.000	1.000
601	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	TGM2(1)	697721	1	1	1	4	1	0	0	0	0	0	0.996	1.000	1.000
602	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	NEK1(1)	1032923	1	1	1	3	0	0	1	0	0	0	0.997	1.000	1.000
603	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1)	787135	1	1	1	2	0	0	1	0	0	0	0.985	1.000	1.000
604	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8		1090041	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
605	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8		1090041	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
606	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5		433444	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
607	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8		1186824	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
608	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9		1171540	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
609	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2		240059	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
610	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7		652482	0	0	0	2	0	0	0	0	0	0	1.000	1.000	1.000
611	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		68167	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
612	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2		294059	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
613	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5		657612	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
614	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4		519909	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
615	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5		544114	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
616	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6		813718	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
