rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(3), IL8(2)	496037	5	5	5	0	1	1	2	0	1	0	0.352	0.0132	1.000
2	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(4), GNAS(6), GNB1(1), GNGT1(1), PRKACA(2)	1769339	14	14	14	1	7	1	4	1	1	0	0.0763	0.0513	1.000
3	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(2), CD4(1), FYN(3), HLA-DRA(1), HLA-DRB1(1), PTPRC(10), ZAP70(2)	2462474	20	19	20	3	9	3	3	1	4	0	0.173	0.0618	1.000
4	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(1), GNAQ(2), GNB1(1), GNGT1(1), HTR2C(2), PLCB1(10), TUB(3)	2066687	20	18	20	3	11	1	3	4	1	0	0.145	0.0665	1.000
5	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	5	NFYA(3), NFYB(1), NFYC(1), SP1(3), SP3(2)	1417365	10	10	10	0	8	0	2	0	0	0	0.0763	0.0697	1.000
6	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(3), GSTZ1(1), HGD(2)	656562	6	6	6	0	5	0	0	1	0	0	0.145	0.0783	1.000
7	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(1), IFNGR1(6), IFNGR2(3), JAK1(1), JAK2(6), STAT1(2)	2394449	19	18	18	3	9	2	0	0	7	1	0.325	0.0853	1.000
8	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(2), F13B(2), HSD17B4(10), HSD17B7(2), HSD3B1(2), HSD3B2(1)	2356166	19	14	19	2	10	0	4	3	2	0	0.0739	0.114	1.000
9	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), HADH(1), HSD17B10(1), HSD17B4(10), MECR(1), PPT1(1), PPT2(1)	2402078	16	13	16	1	7	2	3	2	2	0	0.0618	0.116	1.000
10	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD34(2), CD3D(2), CD4(1), CD58(2), CD8A(2), IL6(1), IL8(2), KITLG(1)	1811898	13	10	13	2	5	2	3	0	3	0	0.318	0.156	1.000
11	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(1), CD4(1), HLA-DRA(1), HLA-DRB1(1), IL5(1), IL5RA(2), IL6(1)	1420729	8	8	8	1	4	2	2	0	0	0	0.227	0.162	1.000
12	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(1), HLA-DRA(1), HLA-DRB1(1), IL5(1)	746468	4	4	4	1	2	2	0	0	0	0	0.462	0.168	1.000
13	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(3), COQ5(2), COQ6(1), COQ7(1), NDUFB11(3)	1217340	10	10	10	2	5	0	3	0	2	0	0.532	0.171	1.000
14	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(1), PGLYRP2(2)	504526	3	3	3	1	1	1	0	0	1	0	0.726	0.176	1.000
15	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(1), IFNG(1), IL12A(2), IL12B(2)	892904	6	6	6	1	5	0	0	0	1	0	0.551	0.182	1.000
16	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(5), APOBEC1(1), APOBEC3B(1), APOBEC3F(2), APOBEC3G(6), APOBEC4(3)	2134444	18	16	18	3	7	1	8	0	2	0	0.184	0.188	1.000
17	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	FUT1(2), FUT2(3), FUT9(3), GCNT2(3), ST8SIA1(2)	1763764	13	11	13	1	5	1	4	1	2	0	0.0670	0.189	1.000
18	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(1), CYP11A1(3), CYP11B2(3), CYP17A1(2), HSD11B2(1), HSD3B1(2), HSD3B2(1)	1998939	13	12	13	2	5	0	5	1	2	0	0.117	0.199	1.000
19	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	FOSB(3), GRIA2(2)	1032150	5	5	5	1	2	0	1	2	0	0	0.576	0.251	1.000
20	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA11(1), NDUFA5(1), NDUFA8(1), NDUFB7(2), NDUFS1(1), NDUFS2(1), NDUFV1(3)	2085754	11	10	11	0	4	1	2	0	4	0	0.0820	0.265	1.000
21	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(1), CYP2C9(3)	584680	4	4	4	1	3	0	1	0	0	0	0.561	0.267	1.000
22	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT2(1), TAT(3)	760205	4	4	4	0	2	0	2	0	0	0	0.292	0.273	1.000
23	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD4(1), HLA-DRA(1), HLA-DRB1(1)	553381	3	3	3	1	2	1	0	0	0	0	0.600	0.274	1.000
24	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(2), CHAT(2), CHKA(2), PCYT1A(2), PDHA1(1), PDHA2(4), PEMT(1), SLC18A3(1)	1986878	15	14	14	3	6	1	6	1	1	0	0.268	0.281	1.000
25	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	CREBBP(15), DFFA(1), DFFB(1), GZMA(1), GZMB(1), HMGB2(1), PRF1(1), SET(2)	3142891	23	19	22	4	9	2	5	0	6	1	0.223	0.287	1.000
26	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(2), FDPS(4), IDI1(1), SQLE(2)	954797	9	8	9	2	8	1	0	0	0	0	0.468	0.296	1.000
27	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(2), B3GALT5(2), B3GNT5(3), FUT1(2), FUT2(3), ST3GAL3(1)	2071271	13	11	13	2	5	2	2	1	3	0	0.255	0.301	1.000
28	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(4), CREM(1), FHL5(1), FSHR(2), GNAS(6), XPO1(3)	2637517	17	16	17	3	7	1	4	2	3	0	0.391	0.338	1.000
29	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(2), GOT2(1), TAT(3), TYR(2)	1361490	8	8	8	2	4	0	3	0	1	0	0.515	0.343	1.000
30	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	16	IFNG(1), IFNGR1(6), IFNGR2(3), IKBKB(2), JAK2(6), LIN7A(2), NFKB1(2), NFKBIA(2), RELA(7), TNFRSF1A(4), TNFRSF1B(2), TP53(12), USH1C(3), WT1(2)	4596743	54	33	52	9	27	6	7	2	11	1	0.0767	0.344	1.000
31	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(3), ALAS2(2), FECH(1), PPOX(2), UROD(1), UROS(1)	2276029	10	9	10	1	4	0	4	0	2	0	0.201	0.416	1.000
32	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	210091	1	1	1	0	1	0	0	0	0	0	0.701	0.425	1.000
33	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), LARS(3), LARS2(1), PDHA1(1), PDHA2(4), PDHB(2)	2917181	12	11	11	1	7	1	1	1	2	0	0.202	0.427	1.000
34	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMB1(1), PSMB10(2), PSMB2(1), PSMB3(1), PSMB6(1), PSMB8(4), PSMB9(1)	2376232	12	11	12	2	3	1	5	0	3	0	0.408	0.457	1.000
35	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(2)	339223	2	1	2	0	0	1	1	0	0	0	0.597	0.476	1.000
36	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	11	ASAH1(2), BFAR(3), BRAF(2), CREB1(2), CREB3(1), CREB5(5), SNX13(2)	3131404	17	14	17	2	9	1	5	0	2	0	0.178	0.497	1.000
37	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16	CD3D(2), HLA-DRA(1), HLA-DRB1(1), ITK(1), PIK3R1(10)	2944870	15	10	15	1	6	3	3	1	2	0	0.103	0.503	1.000
38	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(5), CPT1A(4), LEP(1), LEPR(8), PRKAA2(3), PRKAG1(1), PRKAG2(2)	4213889	24	21	24	2	17	1	4	0	2	0	0.0508	0.511	1.000
39	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS1(1), DHRS3(2), DHRSX(4), HSD3B7(1), PON1(1), PON2(2), PON3(1), RDH13(1)	2601184	13	12	13	3	6	0	4	2	1	0	0.326	0.521	1.000
40	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(4), CD3D(2), CD4(1), CREBBP(15), GNAS(6), GNB1(1), GNGT1(1), HLA-DRA(1), HLA-DRB1(1), PRKAR2A(1), PTPRC(10), ZAP70(2)	6427096	45	38	44	8	21	3	9	2	9	1	0.0788	0.523	1.000
41	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(4), CD3D(2), CD4(1), CREBBP(15), GNAS(6), GNB1(1), GNGT1(1), HLA-DRA(1), HLA-DRB1(1), PRKAR2A(1), PTPRC(10), ZAP70(2)	6427096	45	38	44	8	21	3	9	2	9	1	0.0788	0.523	1.000
42	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), EHHADH(1), HADH(1), HSD17B10(1), HSD17B4(10), SIRT1(2), SIRT2(1), SIRT5(2), SIRT7(1), VNN2(2)	3473668	22	19	22	3	13	1	2	3	3	0	0.138	0.525	1.000
43	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(4), GABBR1(5), GPRC5B(2), GPRC5D(1), GRM1(3), GRM2(2), GRM3(2), GRM4(1), GRM5(5), GRM7(3), GRM8(6)	5678709	34	26	34	4	19	2	11	2	0	0	0.00396	0.537	1.000
44	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(2), HRAS(1), PTK2B(3), SOS1(5)	2545116	11	9	11	1	4	1	4	1	1	0	0.233	0.544	1.000
45	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(2), DAG1(3), GNAQ(2), ITPKA(1), ITPKB(1)	1700826	9	9	9	2	5	0	3	1	0	0	0.405	0.560	1.000
46	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	MAX(2), MYC(1), SP1(3), SP3(2), TP53(12), WT1(2)	1983094	22	16	21	4	15	2	4	0	1	0	0.254	0.607	1.000
47	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(2), ST3GAL1(2), ST3GAL2(1), ST3GAL5(2), ST6GALNAC2(2), ST8SIA1(2)	1648539	11	11	11	3	5	0	4	0	2	0	0.296	0.610	1.000
48	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(2), CALM3(1), CAMK1(2), CAMK2A(3), CAMK2B(1), CAMK2D(2), CAMK4(2), CAMKK1(1), CAMKK2(4), CREB1(2), SYT1(2)	3402213	22	19	22	4	13	1	6	2	0	0	0.168	0.615	1.000
49	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(1), AOC3(3), CES1(3), ESD(1)	1685080	8	7	8	1	4	0	2	2	0	0	0.257	0.637	1.000
50	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(3), HLCS(2)	918185	5	4	5	0	3	0	0	2	0	0	0.231	0.640	1.000
51	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(2), HK1(2), HK2(4), HK3(1), PGM3(1)	2993197	10	10	10	1	5	1	2	0	2	0	0.165	0.644	1.000
52	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(5), ERBB4(4), NRG2(1), NRG3(3), PRKCA(3), PSEN1(4)	2647186	20	16	20	3	10	1	5	3	1	0	0.189	0.645	1.000
53	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	5	CASP3(1), PDE6D(2)	766797	3	3	3	0	2	0	1	0	0	0	0.406	0.656	1.000
54	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD4(1), HLA-DRA(1), HLA-DRB1(1)	1017993	3	3	3	1	2	1	0	0	0	0	0.635	0.664	1.000
55	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	5	CREBBP(15), ESR1(1), MAPK3(1)	2758476	17	16	16	4	7	0	4	1	4	1	0.401	0.669	1.000
56	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(2), HK1(2), HK2(4), HK3(1), IMPA2(2), ISYNA1(1), PGM3(1)	3404056	13	12	13	1	8	1	2	0	2	0	0.0684	0.672	1.000
57	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(1)	443655	1	1	1	0	1	0	0	0	0	0	0.802	0.703	1.000
58	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(2), FDPS(4), IDI1(1), IDI2(2), SQLE(2)	1267791	11	9	11	3	9	1	0	1	0	0	0.549	0.708	1.000
59	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1B(2), ADH4(1), ADH6(1), ADH7(1), ADHFE1(1)	1631978	6	6	6	2	3	0	1	0	2	0	0.717	0.713	1.000
60	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(5), DLL1(1), FURIN(1), NOTCH1(14), PSEN1(4)	2699809	25	18	25	5	10	2	8	2	3	0	0.201	0.717	1.000
61	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	12	ARNT(3), ASPH(5), COPS5(2), CREB1(2), EDN1(1), HIF1A(5), JUN(2), NOS3(6), P4HB(2)	3544934	28	19	28	4	17	0	6	0	5	0	0.127	0.735	1.000
62	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(3), MTMR2(1), MTMR6(1), PHPT1(1)	1873511	6	6	6	1	3	0	1	0	2	0	0.561	0.741	1.000
63	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	PLCG1(3), PRKCA(3), PTK2B(3)	1945685	9	9	9	2	6	0	2	0	1	0	0.382	0.760	1.000
64	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	6	JAK1(1), JAK2(6), JAK3(4), MAPK3(1), STAT3(2), TYK2(9)	3232432	23	18	23	5	12	1	3	1	4	2	0.220	0.774	1.000
65	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(1), CHRNA1(2)	944062	3	3	3	1	2	1	0	0	0	0	0.632	0.775	1.000
66	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	6	AKT1(3), PIK3R1(10), PLCB1(10), PLCG1(3), PRKCA(3), VAV1(2)	3128646	31	20	30	5	20	1	4	2	4	0	0.115	0.776	1.000
67	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(4), CDO1(2), CSAD(1), GAD1(4)	1682636	11	11	11	4	5	0	3	0	3	0	0.675	0.799	1.000
68	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(1), ADORA3(3), P2RY1(1)	1629688	5	5	5	1	3	1	0	0	1	0	0.219	0.800	1.000
69	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	SUCLA2(1)	634106	1	1	1	1	0	0	0	0	1	0	0.928	0.802	1.000
70	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(2), BMPR1A(1), BMPR1B(2), BMPR2(3)	1790461	8	8	8	2	3	1	2	1	1	0	0.615	0.802	1.000
71	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(2), ACAT2(1)	981353	3	3	3	0	1	1	0	1	0	0	0.454	0.805	1.000
72	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD3D(2), CD8A(2), ITGAL(4), PTPRC(10), THY1(1)	3080645	19	17	19	5	6	3	4	2	4	0	0.393	0.806	1.000
73	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), MIOX(1)	2462901	10	10	10	2	5	0	2	3	0	0	0.371	0.809	1.000
74	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(2), FH(1), MDH1(1), MDH2(1), SDHB(1), SUCLA2(1)	2621441	7	7	7	1	3	0	2	0	2	0	0.423	0.828	1.000
75	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(2), ACP5(1), ACP6(1), ACPT(5), ALPI(3), ALPL(1), ALPP(2), ALPPL2(1), CYP3A43(2), CYP3A5(2), CYP3A7(1), DHRS1(1), DHRS3(2), DHRSX(4), PON1(1), PON2(2), PON3(1)	5269010	32	28	32	6	19	0	10	2	1	0	0.0730	0.834	1.000
76	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	12	AKT1(3), BAD(2), CHRNB1(1), CHRNG(1), MUSK(3), PIK3R1(10), PTK2(2), PTK2B(3), RAPSN(1), TERT(1)	4250616	27	22	26	5	10	2	6	3	6	0	0.163	0.838	1.000
77	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(2), NFKB1(2), NFKBIA(2), PLCB1(10), PRKCA(3), RELA(7)	2382147	26	18	26	5	18	1	2	3	2	0	0.275	0.838	1.000
78	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	13	ACTR2(1), ARPC1A(2), ARPC2(3), CDC42(1), PAK1(1), PDGFRA(2), PIK3R1(10), RAC1(1), WASL(4)	3283634	25	18	25	4	13	1	4	2	5	0	0.235	0.841	1.000
79	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(2), AFMID(1), GRHPR(1), HAO1(2), HAO2(1), MDH1(1), MDH2(1), MTHFD1(1), MTHFD1L(2), MTHFD2(2)	3920475	14	14	14	2	8	0	3	1	2	0	0.205	0.843	1.000
80	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNG(1), IL12A(2), IL12B(2), IL15(2), IL16(2), IL1A(2), IL5(1), IL6(1), IL8(2)	2780996	15	14	15	4	8	2	3	0	2	0	0.496	0.848	1.000
81	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	11	CDK5R1(1), EGR1(3), HRAS(1), KLK2(3), MAP2K1(2), MAPK3(1), NGFR(1)	2192124	12	10	11	3	7	0	4	0	1	0	0.318	0.848	1.000
82	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(3), POLD2(1), POLE(7), POLG(3), POLL(1), POLQ(13)	4877518	29	22	29	4	16	0	7	1	5	0	0.0684	0.858	1.000
83	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(2), UXS1(2)	1161121	4	4	4	1	3	0	0	0	1	0	0.678	0.867	1.000
84	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	13	APC(7), CREBBP(15), CTNNB1(5), FZD1(1), LDB1(4), LEF1(1), PITX2(2), TRRAP(13), WNT1(1)	8129987	49	34	46	8	23	2	12	3	8	1	0.0594	0.867	1.000
85	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(4), ARHGEF1(1), F2R(1), F2RL3(2), GNA12(2), GNA13(3), GNAI1(1), GNAQ(2), GNB1(1), GNGT1(1), PIK3R1(10), PLCB1(10), PPP1R12B(3), PRKCA(3), PTK2B(3), ROCK1(3)	6807904	50	35	50	7	29	1	8	4	8	0	0.0318	0.869	1.000
86	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(2), DNAJC3(3), EIF2S1(3), EIF2S2(2), NFKB1(2), NFKBIA(2), RELA(7), TP53(12)	2940902	33	20	32	7	23	1	3	2	4	0	0.335	0.883	1.000
87	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(1), NR1H3(3), NR1H4(1), RXRA(1)	1548809	6	6	6	2	3	0	3	0	0	0	0.597	0.889	1.000
88	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1), FMOD(1), KERA(1), LUM(1)	1059210	4	4	4	2	1	1	2	0	0	0	0.792	0.890	1.000
89	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(1), CYP2A13(1), CYP2A6(2), CYP2A7(5), NAT1(1), NAT2(1), XDH(2)	2348938	13	10	13	3	10	1	2	0	0	0	0.240	0.896	1.000
90	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2)	2305970	13	12	13	3	8	0	2	3	0	0	0.370	0.902	1.000
91	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2)	2305970	13	12	13	3	8	0	2	3	0	0	0.370	0.902	1.000
92	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(4), CR2(3), HLA-DRA(1), HLA-DRB1(1), ITGAL(4), PTPRC(10)	4333358	23	21	23	5	8	3	3	3	6	0	0.356	0.903	1.000
93	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD3D(2), CD4(1), CXCR3(1), IFNG(1), IL12A(2), IL12B(2), IL12RB1(1), IL12RB2(2), JAK2(6), STAT4(4), TYK2(9)	4372283	31	24	31	8	16	4	3	1	5	2	0.350	0.903	1.000
94	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(2), GRHPR(1), HAO1(2), HAO2(1), MDH1(1), MDH2(1), MTHFD1(1), MTHFD1L(2), MTHFD2(2)	3734683	13	13	13	2	8	0	3	0	2	0	0.241	0.907	1.000
95	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(2), UGP2(2), UXS1(2)	1465089	6	5	6	1	5	0	0	0	1	0	0.501	0.907	1.000
96	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD3D(2), CD4(1), ITGAL(4), PTPRC(10), THY1(1)	3278027	18	16	18	5	6	3	3	2	4	0	0.431	0.910	1.000
97	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	13	AKT1(3), BAD(2), CASP9(1), CHUK(2), GHR(6), NFKB1(2), NFKBIA(2), PDPK1(2), PIK3R1(10), RELA(7)	3487740	37	25	36	7	19	3	6	3	6	0	0.251	0.911	1.000
98	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNG(1), IFNGR1(6), JAK1(1), JAK2(6), PTPRU(3), REG1A(2), STAT1(2)	3352189	21	20	20	5	11	1	1	1	6	1	0.419	0.914	1.000
99	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	16	ADRB2(2), AKT1(3), CALM1(2), CALM3(1), GNAS(6), GNB1(1), GNGT1(1), NFKB1(2), NOS3(6), NPPA(1), NR3C1(4), PIK3R1(10), RELA(7), SYT1(2)	4548706	48	29	47	7	27	3	9	3	6	0	0.0727	0.922	1.000
100	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(3), PNPO(2)	1396942	5	3	5	1	3	0	1	0	1	0	0.569	0.927	1.000
101	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	12	APC(7), CDH1(2), CREBBP(15), MAP2K1(2), MAPK3(1), SKIL(2), TGFB2(1), TGFB3(2), TGFBR1(1), TGFBR2(5)	6094811	38	32	36	8	19	0	6	2	10	1	0.420	0.933	1.000
102	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(3), F13A1(2), F2R(1), FGA(6), FGG(1), PLAT(3), PLAU(1), PLG(1)	3941752	18	17	17	3	11	1	4	2	0	0	0.254	0.933	1.000
103	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(11), CDC25A(2), CDC25B(4), CDC25C(2), CHEK1(1), MYT1(4)	4047880	24	18	23	3	18	0	4	0	2	0	0.186	0.939	1.000
104	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(3), ENO3(4), FARS2(1), GOT2(1), PAH(2), TAT(3), YARS(2)	2403206	16	11	16	5	10	0	2	2	2	0	0.586	0.939	1.000
105	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(4), GNAS(6), GNB1(1), GNGT1(1), PRKAA2(3), PRKAG1(1), PRKAG2(2), PRKAR2A(1)	4342256	19	19	19	3	12	0	5	1	1	0	0.197	0.941	1.000
106	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(1), ACTR2(1), ARPC1A(2), ARPC2(3), CDC42(1), RAC1(1), WASF1(3), WASL(4)	2391419	16	13	16	4	8	0	2	1	5	0	0.571	0.941	1.000
107	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	FLT3(3), IL11(1), IL1A(2), IL6(1), KITLG(1), TGFB2(1), TGFB3(2)	2482835	11	11	11	3	5	0	4	0	2	0	0.536	0.945	1.000
108	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	MST1(2), MST1R(7)	1816693	9	7	9	5	5	1	0	0	3	0	0.931	0.946	1.000
109	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(3), ALAS2(2), CPO(1), FECH(1), GATA1(2), UROD(1), UROS(1)	2445839	11	10	11	3	5	1	5	0	0	0	0.494	0.950	1.000
110	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	FH(1), MDH1(1), OGDH(4), SDHA(4), SUCLA2(1)	2787841	11	11	11	3	5	0	4	0	2	0	0.535	0.951	1.000
111	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(1), GAD1(4), HDC(2), TH(2), TPH1(2)	1736308	11	9	11	4	7	1	2	0	1	0	0.620	0.952	1.000
112	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	8	BAG4(1), BIRC3(1), FADD(1), RIPK1(2), TNFRSF1A(4), TNFRSF1B(2), TRAF2(1)	1837341	12	9	12	4	6	2	1	0	3	0	0.694	0.952	1.000
113	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(4), ADRB2(2), CFTR(4), GNAS(6), PRKAR2A(1)	3648375	17	15	17	4	8	0	4	1	4	0	0.411	0.953	1.000
114	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(2), SEC61A2(2), SRP19(2), SRP68(2), SRP72(2)	2187922	10	9	10	3	5	0	2	2	1	0	0.658	0.953	1.000
115	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	HLA-DRA(1), HLA-DRB1(1), IFNG(1), IFNGR1(6), IFNGR2(3), IL12A(2), IL12B(2), IL12RB1(1), IL12RB2(2), IL18R1(2), IL4R(5)	3582955	26	24	25	7	12	5	3	0	6	0	0.577	0.953	1.000
116	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	11	CHST11(2), CHST12(2), PAPSS1(1), PAPSS2(2), SULT1A1(1), SULT1E1(1), SULT2B1(3), SUOX(3)	2487026	15	11	15	4	9	0	2	3	1	0	0.462	0.959	1.000
117	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), B4GALT7(1), HS3ST2(1), HS3ST3A1(2), HS3ST3B1(1), XYLT2(1)	1793874	7	7	7	6	2	0	3	0	2	0	0.924	0.959	1.000
118	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), B4GALT7(1), HS3ST2(1), HS3ST3A1(2), HS3ST3B1(1), XYLT2(1)	1793874	7	7	7	6	2	0	3	0	2	0	0.924	0.959	1.000
119	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(1), GABRA2(2), GABRA4(1), GABRA5(1), GABRA6(1), PRKCE(1)	2284662	7	7	7	2	3	1	1	0	2	0	0.595	0.960	1.000
120	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	6	CREBBP(15), LPL(2), NCOA1(4), NCOA2(2), PPARG(1), RXRA(1)	3969964	25	23	23	6	11	0	8	0	5	1	0.462	0.961	1.000
121	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1), RAB5A(1), RAB6A(1)	1257886	3	3	3	2	1	0	1	0	1	0	0.922	0.962	1.000
122	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(6)	2476653	7	6	7	0	5	1	0	0	1	0	0.308	0.964	1.000
123	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(3), ACO1(2), ACSS1(3), ACSS2(2), FH(1), MDH1(1), MDH2(1), SUCLA2(1)	3883753	14	13	14	3	8	0	4	0	2	0	0.315	0.967	1.000
124	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	9	B2M(3), CD3D(2), GZMB(1), ITGAL(4), PRF1(1)	2336262	11	9	11	4	4	2	3	0	2	0	0.494	0.970	1.000
125	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	SHMT1(2), SHMT2(1)	1256499	3	3	3	4	2	0	0	0	1	0	0.975	0.970	1.000
126	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(1), DHRS3(2), DHRSX(4), ESCO1(1), ESCO2(1), NAT6(1), PNPLA3(1), SH3GLB1(2)	4731422	13	12	13	2	7	0	3	2	1	0	0.331	0.970	1.000
127	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ADAM10(2), ANKRD1(1), CYR61(1), IFNG(1), IL1A(2), IL1R1(2), MYOG(1)	3113649	10	10	10	2	6	0	1	2	1	0	0.447	0.970	1.000
128	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA2(1), IL4R(5), JAK1(1), JAK2(6), TYK2(9)	3054141	22	17	22	7	10	2	5	1	2	2	0.601	0.972	1.000
129	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA2(1), IL4R(5), JAK1(1), JAK2(6), TYK2(9)	3054141	22	17	22	7	10	2	5	1	2	2	0.601	0.972	1.000
130	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(3), BAD(2), BAK1(1), BCL2L11(3), BID(1), CASP9(1), CES1(3)	3356348	14	13	14	4	3	0	4	2	5	0	0.787	0.973	1.000
131	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), BCAT2(2), IARS2(3), LARS(3), LARS2(1), PDHA1(1), PDHA2(4), PDHB(2), VARS(2), VARS2(1)	4708158	20	18	19	4	12	1	2	1	4	0	0.324	0.973	1.000
132	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	18	B2M(3), ITGB1(2), KLRC4(1), KLRD1(2), LAT(1), MAP2K1(2), MAPK3(1), PAK1(1), PIK3R1(10), PTK2B(3), RAC1(1), SYK(1), VAV1(2)	4692529	30	23	30	6	13	1	7	2	7	0	0.264	0.974	1.000
133	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(1), MMP2(6), MMP9(1), RECK(3), TIMP1(1), TIMP2(1)	2225502	13	10	13	3	7	2	3	1	0	0	0.359	0.974	1.000
134	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADM(4), ACADS(3), ACAT1(2)	1560843	9	5	9	3	4	1	2	1	1	0	0.736	0.975	1.000
135	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	EPHX2(2), HSD3B7(1), RDH13(1)	1384183	4	4	4	2	3	0	1	0	0	0	0.733	0.976	1.000
136	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	20	CCR3(1), GNAQ(2), GNAS(6), GNB1(1), GNGT1(1), HRAS(1), LIMK1(4), MAP2K1(2), MAPK3(1), NOX1(2), PIK3C2G(5), PLCB1(10), PPP1R12B(3), PRKCA(3), PTK2(2), ROCK2(4)	7185502	48	33	48	6	29	1	11	4	3	0	0.0328	0.976	1.000
137	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(1), ITPKA(1), PDE1A(3), PDE1B(2), PLCB1(10), PLCB2(2), PRL(3), TRH(2), VIP(2)	3195227	26	22	26	7	15	2	4	2	3	0	0.436	0.977	1.000
138	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(1), ACOX3(2), PLA2G12A(1), PLA2G12B(3), PLA2G2D(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2)	3060281	14	10	14	2	9	0	3	1	1	0	0.141	0.978	1.000
139	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(3), BLVRA(1), CP(2), EPRS(7), FECH(1), GUSB(4), HMOX1(2), PPOX(2), UGT1A1(2), UGT1A4(1), UGT1A5(1), UGT1A6(1), UGT2B15(5), UGT2B4(1), UROD(1), UROS(1)	7953409	35	25	35	5	24	0	4	3	4	0	0.0480	0.979	1.000
140	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), BCKDK(1), CBS(1)	1424653	3	3	3	3	1	0	1	0	1	0	0.973	0.979	1.000
141	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3D(2), IFNG(1), TGFB2(1), TGFB3(2), TGFBR1(1), TGFBR2(5), TOB2(2)	3116087	14	12	14	7	6	1	2	1	4	0	0.921	0.979	1.000
142	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(1), EGFR(7), ERBB3(12), NRG1(1), UBE2D1(1)	2959798	22	18	19	5	11	1	7	2	1	0	0.399	0.979	1.000
143	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT3(1), B4GALT5(1), FUT8(3), ST3GAL1(2), ST3GAL2(1), ST3GAL3(1)	2275445	9	8	9	5	4	0	2	0	3	0	0.863	0.980	1.000
144	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	12	CARM1(1), CREB1(2), CREBBP(15), NCOA3(1), PRKAR2A(1), RXRA(1)	4613726	21	20	20	5	9	0	7	0	4	1	0.423	0.980	1.000
145	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(3), MDH1(1), ME1(1), PC(1), PDHA1(1), SLC25A1(1), SLC25A11(1)	2711819	9	9	9	3	4	1	3	0	1	0	0.609	0.981	1.000
146	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	10	CREB1(2), FOS(2), JUN(2), KEAP1(1), MAPK8(1), PRKCA(3)	2062756	11	11	11	4	6	0	4	0	1	0	0.658	0.982	1.000
147	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	14	CUZD1(2), FOS(2), HRAS(1), JUN(2), MAP2K1(2), MAPK3(1), MYC(1), NFKB1(2), NFKBIA(2), PLCB1(10), PRKCA(3), RELA(7)	4197358	35	25	35	9	23	1	5	2	4	0	0.340	0.986	1.000
148	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(4), ABCB11(4), ABCB4(5), ABCC1(1), ABCC3(9)	4241904	23	17	23	6	11	0	7	1	4	0	0.275	0.986	1.000
149	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(2), FUT2(3), FUT6(1), ST3GAL3(1)	1459781	7	5	7	4	2	1	1	2	1	0	0.877	0.987	1.000
150	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	13	AKT1(3), CREB1(2), MAP2K1(2), MAP2K3(2), MAP3K1(4), MAPK3(1), NFKB1(2), PIK3R1(10), RELA(7), SP1(3)	4391638	36	22	35	6	21	2	7	3	3	0	0.158	0.987	1.000
151	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(2), ACAT2(1), BDH1(1), HMGCS1(1)	2078101	5	4	5	1	3	1	0	1	0	0	0.562	0.988	1.000
152	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD3D(2), CD4(1)	948017	3	2	3	2	1	1	1	0	0	0	0.837	0.989	1.000
153	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(1), PARK2(2), SNCAIP(4), UBE2L6(1)	1841570	8	8	8	3	3	0	2	1	2	0	0.774	0.991	1.000
154	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(1), IL8(2), NFKB1(2), NOX1(2), RELA(7), XDH(2)	2836983	16	11	16	5	6	2	4	1	3	0	0.631	0.991	1.000
155	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1B(2), ADH4(1), ADH6(1), ADH7(1), ADHFE1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2)	3868886	15	15	15	4	8	0	2	3	2	0	0.451	0.991	1.000
156	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(2), PLCD1(2), PRKCA(3)	1435438	7	7	7	4	5	0	1	0	1	0	0.764	0.991	1.000
157	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(1), CYP2E1(1), PTGS2(2)	1538025	4	4	4	3	3	0	0	0	1	0	0.878	0.991	1.000
158	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(1), GOT2(1), PAH(2), TAT(3), YARS(2), YARS2(1)	2538190	10	8	10	3	6	0	2	1	1	0	0.610	0.992	1.000
159	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(1), GABARAP(1), GABRA1(1), GABRA2(2), GABRA4(1), GABRA5(1), GABRA6(1), NSF(1), UBQLN1(4)	3500288	13	13	13	3	7	2	1	0	3	0	0.408	0.992	1.000
160	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	SHMT1(2), SHMT2(1)	1662499	3	3	3	4	2	0	0	0	1	0	0.982	0.992	1.000
161	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(3), GLUD1(2), PRODH(1)	1661272	6	6	6	5	4	0	1	0	1	0	0.974	0.992	1.000
162	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(1), DHRS1(1), DHRS3(2), DHRSX(4), HEMK1(1), LCMT1(4), LCMT2(1), METTL2B(1), PRMT2(1), PRMT5(1), PRMT6(1), PRMT7(3)	4294210	21	18	21	5	11	1	5	1	3	0	0.286	0.993	1.000
163	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	ABCB1(4), AKT1(3), ATM(11), CDKN1A(1), CPB2(3), CSNK1D(2), HIF1A(5), MAPK8(1), MDM2(1), NQO1(1), TP53(12)	5765618	44	31	41	6	30	1	8	2	3	0	0.0917	0.993	1.000
164	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(1), CD8A(2), IL11(1), IL5(1), IL6(1), IL8(2)	1800708	8	7	8	5	3	2	2	0	1	0	0.901	0.993	1.000
165	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(1), MBTPS1(3), SCAP(1), SREBF1(3), SREBF2(2)	3465430	11	9	11	3	7	0	2	0	2	0	0.392	0.993	1.000
166	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(1), IL6R(3), JAK1(1), JAK2(6), JAK3(4), PIAS3(2), PTPRU(3), REG1A(2), STAT3(2)	4458683	24	19	23	7	13	1	4	1	4	1	0.394	0.993	1.000
167	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), EHHADH(1), SDS(1)	1432488	3	3	3	2	2	0	0	0	1	0	0.861	0.994	1.000
168	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(3), CDKN1A(1), EPOR(1), HIF1A(5), JAK2(6), NFKB1(2), NFKBIA(2), RELA(7)	3795591	27	19	27	7	15	2	4	1	4	1	0.524	0.994	1.000
169	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), SHMT1(2)	4464638	16	15	16	5	3	0	5	1	7	0	0.536	0.994	1.000
170	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), SHMT1(2)	4464638	16	15	16	5	3	0	5	1	7	0	0.536	0.994	1.000
171	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), SHMT1(2)	4464638	16	15	16	5	3	0	5	1	7	0	0.536	0.994	1.000
172	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	11	APAF1(3), ARHGAP5(4), CASP1(1), CASP10(1), CASP3(1), CASP9(1), GZMB(1), JUN(2), PRF1(1)	3381780	15	13	15	4	8	0	2	0	5	0	0.616	0.995	1.000
173	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(11), ATR(6), CDC25C(2), CHEK1(1), CHEK2(1), TP53(12)	4624531	33	24	31	5	25	0	4	1	3	0	0.263	0.995	1.000
174	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(1), CD36(2), FOS(2), FYN(3), JUN(2), THBS1(2)	2102412	12	9	12	4	8	1	2	0	1	0	0.696	0.995	1.000
175	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(1), ADH1B(2), ADH4(1), ADH6(1), ADH7(1), ADHFE1(1), AKR1C4(2), AKR1D1(2), ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), BAAT(4), CEL(3), CYP27A1(3), CYP7A1(2), SOAT2(2)	6750067	38	28	38	9	20	2	9	3	4	0	0.207	0.995	1.000
176	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	NDUFA1(1), SDHA(4), SDHB(1), SDHD(1), UQCRC1(1)	1888486	8	7	8	5	4	1	2	0	1	0	0.946	0.996	1.000
177	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	12	CCNA1(2), CCNA2(2), CCND1(1), CDK2(1), E2F2(1), E2F4(1), PRB1(1)	2493517	9	8	9	4	3	0	1	3	2	0	0.868	0.996	1.000
178	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	CAPN1(5), CAPNS1(1), CDK5R1(1), CSNK1D(2), MAPT(2)	2738707	11	9	11	4	5	2	3	0	1	0	0.680	0.996	1.000
179	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(4), ARHGEF1(1), GNA12(2), GNA13(3), GNAQ(2), GNB1(1), GNGT1(1), MYLK(2), PLCB1(10), PPP1R12B(3), PRKCA(3), ROCK1(3)	6054489	35	27	35	6	22	0	4	3	6	0	0.173	0.996	1.000
180	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXTL1(2), EXTL3(1), HS2ST1(1), HS3ST2(1), HS3ST3A1(2), HS3ST3B1(1), HS3ST5(1), HS6ST2(5), NDST2(4), NDST3(5), NDST4(4)	5974807	27	22	27	6	12	0	8	4	3	0	0.184	0.996	1.000
181	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(2), FOSL2(2), IFNAR1(3), IFNAR2(2), MAPK8(1), NFKB1(2), RELA(7), TNFSF11(1), TRAF6(1)	3130743	21	14	21	5	13	1	3	1	3	0	0.549	0.997	1.000
182	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(15), DAXX(2), HRAS(1), PAX3(2), PML(6), SIRT1(2), SP100(7), TNFRSF1A(4), TNFRSF1B(2), TP53(12)	4818201	53	31	51	12	30	2	10	2	8	1	0.229	0.997	1.000
183	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	15	AKT1(3), CREB1(2), HRAS(1), MAPK3(1), MAPK7(2), MEF2A(1), MEF2B(1), MEF2C(1), MEF2D(3), PIK3R1(10), PLCG1(3), RPS6KA1(1)	4906728	29	20	28	5	13	3	7	2	4	0	0.149	0.997	1.000
184	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(2), CHAT(2), DBH(1), DDC(2), GAD1(4), HDC(2), MAOA(1), PAH(2), SLC18A3(1), TH(2), TPH1(2)	4159064	21	18	21	6	10	1	6	1	3	0	0.440	0.997	1.000
185	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), FDXR(1), SHMT1(2)	4713736	17	16	17	5	3	0	6	1	7	0	0.479	0.997	1.000
186	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSS(1), HPRT1(1), IMPDH1(2), MTHFD2(2), OAZ1(2), POLB(1), POLD1(3), POLG(3), PRPS2(2), RRM1(2), SRM(1)	3701318	20	18	20	5	11	1	5	1	2	0	0.393	0.997	1.000
187	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(3), ALPL(1), ALPP(2), ALPPL2(1), GGH(2)	1858101	9	8	9	4	6	0	3	0	0	0	0.655	0.997	1.000
188	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(11), CDC25A(2), CDC25B(4), CDC25C(2), CDK2(1), CHEK1(1), MYT1(4), TP53(12)	4655472	37	25	35	7	28	0	6	0	3	0	0.284	0.997	1.000
189	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), AKR1D1(2), CYP11A1(3), CYP11B1(1), CYP11B2(3), CYP17A1(2), CYP21A2(1), HSD11B2(1), HSD3B1(2), HSD3B2(1)	2774316	18	16	18	7	7	1	7	1	2	0	0.554	0.998	1.000
190	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), AKR1D1(2), CYP11A1(3), CYP11B1(1), CYP11B2(3), CYP17A1(2), CYP21A2(1), HSD11B2(1), HSD3B1(2), HSD3B2(1)	2774316	18	16	18	7	7	1	7	1	2	0	0.554	0.998	1.000
191	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(1), HLA-DRA(1), HLA-DRB1(1), IFNG(1), IL11(1), IL12A(2), IL12B(2), IL15(2), IL1A(2), IL5(1), IL6(1), IL8(2), TGFB2(1), TGFB3(2)	3733306	20	18	20	9	12	3	2	0	3	0	0.793	0.998	1.000
192	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CDC25A(2), CDC25B(4), CDC25C(2), XPO1(3)	2499885	11	8	11	3	8	0	1	1	1	0	0.688	0.998	1.000
193	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(1), ACTR2(1), ARPC1A(2), ARPC2(3), NCK1(2), NCKAP1(3), PIR(1), RAC1(1), WASF1(3), WASF2(2), WASF3(1), WASL(4)	4496973	24	21	24	5	10	0	6	2	6	0	0.391	0.998	1.000
194	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(1), JAK2(6), JAK3(4), PIAS3(2), PTPRU(3), REG1A(2)	4039984	18	17	17	5	9	1	3	1	3	1	0.470	0.998	1.000
195	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	APAF1(3), ATM(11), CCND1(1), CDK2(1), CDKN1A(1), MDM2(1), PCNA(1), TP53(12)	4773455	31	25	29	8	19	0	6	1	5	0	0.579	0.998	1.000
196	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	8	CCNA1(2), CDK2(1), CUL1(4), TFDP1(2)	2022476	9	7	9	6	5	1	0	2	1	0	0.948	0.998	1.000
197	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS1(1), PAPSS2(2), SULT1E1(1), SUOX(3)	1770139	7	5	7	3	3	0	1	2	1	0	0.824	0.998	1.000
198	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(1), ENO1(3), GPI(3), HK1(2), PGAM1(1), PGK1(1), PKLR(3)	2695803	14	13	14	6	6	0	5	1	2	0	0.682	0.998	1.000
199	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(2), HDAC9(3), MEF2A(1), MEF2B(1), MEF2C(1), MEF2D(3)	2396575	11	9	11	4	5	2	0	2	2	0	0.837	0.998	1.000
200	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	FDFT1(2), FDPS(4), HMGCR(1), IDI1(1), LSS(2), MVD(1), MVK(1), NQO1(1), PMVK(1), SQLE(2), VKORC1(1)	3231823	17	14	17	5	11	1	0	2	3	0	0.439	0.999	1.000
201	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(9), GNA12(2), PRKAG1(1), PRKAR2A(1)	2904144	13	11	13	5	10	0	0	1	2	0	0.809	0.999	1.000
202	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(2), ACAT2(1), EHHADH(1), GCDH(2), SDHB(1), SDS(1)	2296233	8	8	8	3	3	1	2	1	1	0	0.717	0.999	1.000
203	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(3), ALAS2(2), BLVRA(1), COX10(1), CP(2), EPRS(7), FECH(1), GUSB(4), HMOX1(2), MMAB(1), PPOX(2), UGT1A1(2), UGT1A4(1), UGT1A5(1), UGT1A6(1), UGT2A1(2), UGT2A3(3), UGT2B10(3), UGT2B11(3), UGT2B15(5), UGT2B17(3), UGT2B4(1), UGT2B7(1), UROD(1), UROS(1)	12336219	54	40	54	9	35	0	7	7	5	0	0.0396	0.999	1.000
204	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	11	AKT1(3), HRAS(1), KLK2(3), PIK3R1(10), PLCG1(3), PRKCA(3), SOS1(5)	3903585	28	19	26	6	17	2	5	2	2	0	0.269	0.999	1.000
205	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(2), ACP5(1), ACPT(5), ENPP1(2), ENPP3(5), FLAD1(3), TYR(2)	2864807	20	18	20	7	10	0	6	2	2	0	0.699	0.999	1.000
206	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(2), CALM3(1), CXCR4(3), FOS(2), GNAQ(2), JUN(2), MAPK8(1), PLCG1(3), PRKCA(3), PTK2B(3), SYT1(2)	3949464	24	21	24	7	14	1	4	2	3	0	0.425	0.999	1.000
207	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADM(4), ACADS(3), ACADVL(2), ACSL1(1), ACSL3(2), ACSL4(5), CPT1A(4), CPT2(1), EHHADH(1), SCP2(1)	4871776	24	16	24	7	12	2	3	0	7	0	0.512	0.999	1.000
208	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(1), ACAT1(2), ACAT2(1), EHHADH(1), SDS(1)	2460774	6	5	6	2	2	1	0	1	2	0	0.674	0.999	1.000
209	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(2), ACP5(1), ACP6(1), ACPT(5), ENPP1(2), ENPP3(5), FLAD1(3), MTMR1(3), MTMR2(1), MTMR6(1), PHPT1(1), TYR(2)	4416450	27	25	27	7	14	0	7	2	4	0	0.486	0.999	1.000
210	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(2), IL6(1), LDLR(1), LPL(2)	1527206	6	6	6	3	3	0	2	1	0	0	0.845	0.999	1.000
211	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	20	F2R(1), F2RL3(2), GNAI1(1), GNB1(1), GNGT1(1), HRAS(1), ITGA1(3), ITGB1(2), MAP2K1(2), MAPK3(1), PLA2G4A(3), PLCB1(10), PRKCA(3), PTK2(2), SYK(1)	6885360	34	25	34	6	20	1	9	3	1	0	0.125	0.999	1.000
212	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(3), CTSD(1), ESR1(1), GREB1(3), HSPB1(1), MTA1(2), PDZK1(1), TUBA8(2)	3123710	14	12	14	5	9	1	2	1	1	0	0.525	0.999	1.000
213	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT1(2), FUT2(3), FUT9(3), GLA(1), HEXB(2), ST3GAL1(2), ST3GAL2(1), ST8SIA1(2)	2878006	16	13	16	7	4	2	7	1	2	0	0.702	0.999	1.000
214	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	14	CCND1(1), CDK2(1), CDKN1A(1), E2F2(1), MDM2(1), NXT1(1), PRB1(1), TP53(12)	2296712	19	16	18	7	11	0	5	2	1	0	0.710	0.999	1.000
215	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(1), AGT(2), AGTR1(1), NOS3(6), REN(1)	2924561	11	9	11	9	5	1	3	0	2	0	0.965	0.999	1.000
216	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(3), BST1(4), ENPP1(2), ENPP3(5), NADK(3), NADSYN1(5), NMNAT3(1), NNMT(1), NNT(1), NT5C(2), NT5C1A(2), NT5C1B(2), NT5C2(3), NT5E(1), NUDT12(2), QPRT(1)	6240129	38	26	38	8	18	1	10	5	4	0	0.204	0.999	1.000
217	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	19	AKT1(3), EIF4A1(3), EIF4A2(3), EIF4G1(5), EIF4G3(4), GHR(6), IRS1(2), MAPK3(1), MKNK1(1), PDK2(1), PDPK1(2), PIK3R1(10), PRKCA(3), RPS6KB1(1)	7081009	45	24	44	8	25	4	8	2	6	0	0.183	1.000	1.000
218	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	13	CHUK(2), DUSP1(1), IKBKAP(3), IKBKB(2), MAP3K1(4), NFKB1(2), NFKBIA(2), RELA(7), TNFAIP3(2), TRAF3(3), TRAF6(1)	5403394	29	20	28	7	17	1	6	2	3	0	0.459	1.000	1.000
219	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(3), ENPP1(2), ENPP3(5), NADSYN1(5), NNMT(1), NNT(1), NT5C(2), NT5E(1), QPRT(1)	4201389	21	17	21	8	8	0	6	3	4	0	0.762	1.000	1.000
220	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALNT1(1), B3GALT5(2), FUT1(2), FUT2(3), FUT9(3), GLA(1), HEXB(2), ST3GAL1(2), ST3GAL2(1), ST8SIA1(2)	3054207	19	14	19	7	5	4	7	1	2	0	0.575	1.000	1.000
221	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(6), C5(3), C6(5), C7(3), C9(1)	3721766	18	13	18	5	10	2	3	1	2	0	0.637	1.000	1.000
222	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT3(1), B3GNT5(3), B4GALT3(1), B4GALT4(1), FUT1(2), FUT2(3), FUT6(1), FUT9(3), GCNT2(3), ST3GAL6(1), ST8SIA1(2)	4588929	21	18	21	9	9	2	4	2	4	0	0.763	1.000	1.000
223	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1R(1), C1S(1), C2(1), C3(6), C5(3), C6(5), C7(3), C9(1)	4960906	21	15	21	5	11	3	4	1	2	0	0.459	1.000	1.000
224	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(2), ITGAL(4), ITGAM(4), SELE(1), SELL(1)	3167855	12	11	12	6	6	1	3	0	2	0	0.798	1.000	1.000
225	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(3), BAK1(1), BID(1), BIK(1), BIRC2(2), BIRC3(1), CASP3(1), CASP6(2), CASP9(1), DFFA(1), DFFB(1)	3596131	15	12	15	5	5	1	5	1	3	0	0.747	1.000	1.000
226	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(3), EGF(1), EGFR(7), HGS(2), RAB5A(1)	3737155	14	11	14	7	7	0	4	1	2	0	0.932	1.000	1.000
227	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(3), AASS(2)	2023037	5	5	5	2	5	0	0	0	0	0	0.842	1.000	1.000
228	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(2), GNAS(6), GNB1(1), GNGT1(1), PRKAR2A(1), PRKCA(3)	2743177	14	11	14	4	10	0	3	1	0	0	0.575	1.000	1.000
229	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(2), ITGA4(6), ITGAL(4), ITGB1(2), SELE(1), SELL(1)	3608559	16	15	16	8	8	2	4	0	2	0	0.902	1.000	1.000
230	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), APAF1(3), CASP3(1), CASP9(1), DAXX(2), FAS(5), FASLG(1), HSPB1(1), IL1A(2), MAPKAPK2(2), MAPKAPK3(1)	3182126	20	16	19	7	13	0	5	0	2	0	0.671	1.000	1.000
231	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(2), CDC25B(4), CDC25C(2), PRKCA(3), PTPRA(2)	2702582	13	8	13	3	13	0	0	0	0	0	0.337	1.000	1.000
232	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(1), F11(1), F12(1), F13B(2), F5(7), F7(2), F8(9), F9(3), FGA(6), FGG(1), LPA(2), PLAT(3), PLAU(1), PLG(1), SERPINF2(1), VWF(6)	10237278	47	29	46	7	18	4	14	5	5	1	0.0695	1.000	1.000
233	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CYB5R3(1), GCK(2), GFPT1(3), GNE(3), HEXB(2), HK1(2), HK2(4), HK3(1), PGM3(1), UAP1(2)	5027079	21	21	21	6	11	2	4	1	3	0	0.452	1.000	1.000
234	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	18	BAD(2), FADD(1), MAP2K1(2), MAP3K1(4), MAPK3(1), MAPK8(1), NFKB1(2), NSMAF(4), RELA(7), RIPK1(2), SMPD1(3), TNFRSF1A(4), TRAF2(1)	5293734	34	22	34	9	14	3	9	2	6	0	0.467	1.000	1.000
235	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	21	ACTA1(1), ADCY1(4), CAP1(1), CDC25C(2), GNAI1(1), GNAS(6), GNB1(1), GNGT1(1), HRAS(1), MAPK3(1), MYT1(4), PIN1(1), PRKAR2A(1), RPS6KA1(1)	5691545	26	21	26	6	13	0	9	2	2	0	0.296	1.000	1.000
236	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(2), CDC25B(4), CDKN1A(1), CHEK1(1), NEK1(2)	2188379	10	7	10	3	9	0	1	0	0	0	0.803	1.000	1.000
237	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	13	AKT1(3), AKT2(1), AKT3(3), MAPK3(1), PDK1(3), PIK3CD(1), PTK2B(3), RBL2(2), SOS1(5)	4812384	22	17	21	6	14	1	3	1	3	0	0.479	1.000	1.000
238	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	14	APAF1(3), BIRC2(2), BIRC3(1), CASP10(1), CASP3(1), CASP9(1), DFFA(1), DFFB(1), GZMB(1), PRF1(1), SCAP(1), SREBF1(3), SREBF2(2)	4946414	19	16	19	5	9	1	4	0	5	0	0.405	1.000	1.000
239	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B4GALT3(1), B4GALT4(1), CHST4(2), FUT8(3), ST3GAL1(2), ST3GAL2(1), ST3GAL3(1)	3396497	11	9	11	8	7	0	2	0	2	0	0.939	1.000	1.000
240	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	GOSR2(1), SNAP23(2), STX11(3), STX2(1), STX3(2), STX5(1), STX6(1), STX7(1), STX8(2), TSNARE1(1), VAMP5(2)	4900074	17	14	17	8	8	0	3	2	4	0	0.867	1.000	1.000
241	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(2), EIF2B5(1), EIF2S1(3), EIF2S2(2), EIF5(1)	3303132	9	7	9	3	8	0	0	0	1	0	0.773	1.000	1.000
242	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(3), FTCD(3), GART(1), MTHFD1(1), MTHFD1L(2), MTHFD2(2), MTHFR(4), MTR(2), SHMT1(2), SHMT2(1)	5537882	21	20	21	8	9	1	5	2	4	0	0.783	1.000	1.000
243	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(2), CYSLTR2(1), GPR161(1), GPR171(1), GPR18(1), GPR34(1), GPR39(2), GPR45(2), GPR65(1), GPR68(1), GPR75(1)	2880915	14	12	14	7	5	0	6	2	1	0	0.706	1.000	1.000
244	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	UBE2D1(1), UBE2E1(2), UBE2H(1), UBE2I(1), UBE2J2(2), UBE2L6(1), UBE3A(3)	3058751	11	11	11	4	8	1	1	0	1	0	0.762	1.000	1.000
245	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMB1(1), PSMB2(1), PSMB3(1), PSMB6(1), PSMC3(1), RPN1(2), UBE3A(3)	3832228	11	11	11	4	5	2	2	0	2	0	0.756	1.000	1.000
246	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	17	ELK1(2), FOS(2), HRAS(1), JUN(2), KLK2(3), MAP2K1(2), MAPK3(1), MAPK8(1), NGFR(1), PIK3R1(10), PLCG1(3), SOS1(5)	4857887	33	21	32	8	16	2	9	2	4	0	0.361	1.000	1.000
247	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(2), FOS(2), HRAS(1), IL3RA(2), JAK2(6), MAP2K1(2), MAPK3(1), SOS1(5), STAT5A(2), STAT5B(1)	5202063	24	18	24	7	11	2	6	2	2	1	0.496	1.000	1.000
248	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(2), ITGA4(6), ITGAL(4), ITGAM(4), ITGB1(2), SELE(1), SELL(1)	4778895	20	19	20	8	11	2	4	0	3	0	0.760	1.000	1.000
249	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5R1(1), FYN(3), LRP8(1), RELN(7), VLDLR(3)	4059547	15	13	15	8	8	0	4	1	2	0	0.945	1.000	1.000
250	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG3(2), ATG5(1), ATG7(1), BECN1(1), GABARAP(1), GABARAPL1(1), IFNA10(1), IFNA4(1), IFNA5(1), IFNA6(1), IFNA8(1), IFNG(1), PIK3C3(4), PIK3R4(2), PRKAA2(3), ULK1(2), ULK2(3)	6260292	28	23	28	7	16	1	5	2	4	0	0.398	1.000	1.000
251	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(2), CREM(1), FOS(2), JUN(2), MAPK3(1), POLR2A(5), PRKAR2A(1)	3734903	14	14	14	8	8	0	3	1	2	0	0.937	1.000	1.000
252	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(2), FH(1), IDH3A(2), IDH3B(1), IDH3G(1), MDH1(1), MDH2(1), PC(1), SDHA(4), SDHB(1), SUCLA2(1), SUCLG1(1), SUCLG2(1)	6074390	18	17	18	5	9	0	4	0	5	0	0.457	1.000	1.000
253	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	FDFT1(2), FDPS(4), HMGCR(1), HMGCS1(1), IDI1(1), LSS(2), MVD(1), MVK(1), NSDHL(2), PMVK(1), SQLE(2)	3870919	18	15	18	6	11	1	1	2	3	0	0.575	1.000	1.000
254	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(1), CD5(1), IFNG(1), IL12A(2), IL12B(2), IL5(1), ITGAX(3), TLR2(2), TLR4(2), TLR7(4), TLR9(2)	5444005	21	17	21	7	12	2	2	3	2	0	0.510	1.000	1.000
255	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX1(1), ACOX3(2), ELOVL2(1), ELOVL5(1), FADS1(2), FASN(4), HSD17B12(1)	4285006	12	10	12	6	7	0	2	1	2	0	0.715	1.000	1.000
256	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(1), DFFA(1), DFFB(1), GZMB(1), HMGB1(1), HMGB2(1), TOP2A(2), TOP2B(2)	3006185	10	8	10	4	7	2	0	0	1	0	0.899	1.000	1.000
257	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(3), IL4R(5), IRS1(2), JAK1(1), JAK3(4), RPS6KB1(1), STAT6(3)	4259839	19	15	18	5	11	1	5	0	2	0	0.349	1.000	1.000
258	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	IL5(1), JUNB(2), MAP2K3(2), NFATC1(4), NFATC2(4), PRKAR2A(1)	3256961	14	13	14	9	10	2	1	0	1	0	0.933	1.000	1.000
259	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	29	AKR1C4(2), AKR1D1(2), ARSE(1), CYP11B1(1), CYP11B2(3), HSD11B2(1), HSD3B1(2), HSD3B2(1), STS(2), SULT1E1(1), UGT1A1(2), UGT1A4(1), UGT1A5(1), UGT1A6(1), UGT2B15(5), UGT2B4(1)	7811721	27	24	27	8	15	2	3	4	3	0	0.391	1.000	1.000
260	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(3), GART(1), MTHFD1(1), MTHFD1L(2), MTHFD2(2), MTHFR(4), MTR(2), SHMT1(2), SHMT2(1)	5231737	18	17	18	8	9	1	3	2	3	0	0.864	1.000	1.000
261	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(1), CRY1(1), CRY2(1), CSNK1D(2), NPAS2(4), NR1D1(2), PER1(3), PER2(1), PER3(7)	4901223	22	20	22	7	14	3	2	1	2	0	0.677	1.000	1.000
262	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(5), APC(7), BTRC(1), CTNNB1(5), DLL1(1), FZD1(1), NOTCH1(14), PSEN1(4), WNT1(1)	6114748	39	26	37	9	19	2	10	5	3	0	0.402	1.000	1.000
263	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(1), F2R(1), F5(7), F7(2), FGA(6), FGG(1), PROS1(2), SERPINC1(1), TFPI(1)	4770264	22	15	21	5	14	2	5	0	1	0	0.416	1.000	1.000
264	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	20	ADCY1(4), AKT1(3), ASAH1(2), GNAI1(1), GNB1(1), GNGT1(1), ITGAV(1), ITGB3(3), MAPK3(1), PDGFRA(2), PIK3R1(10), PLCB1(10), PRKCA(3), PTK2(2), RAC1(1), SMPD1(3), SMPD2(1), SPHK1(1)	7108345	50	29	49	11	31	2	8	3	6	0	0.144	1.000	1.000
265	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	13	AKT1(3), ITGB1(2), MAPK3(1), PDK2(1), PDPK1(2), PIK3R1(10), PTK2(2), SOS1(5)	4526001	26	16	25	6	13	4	5	2	2	0	0.463	1.000	1.000
266	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(4), ADRB2(2), GNAS(6), PLCE1(9), PRKAR2A(1)	4142653	22	20	22	7	14	0	5	1	2	0	0.601	1.000	1.000
267	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(1), DHCR24(1), FDFT1(2), FDPS(4), GGCX(3), HMGCR(1), HSD17B7(2), IDI1(1), IDI2(2), LSS(2), MVD(1), MVK(1), NQO1(1), NSDHL(2), PMVK(1), SQLE(2), TM7SF2(1), VKORC1(1)	5617871	29	22	29	9	17	1	3	4	4	0	0.424	1.000	1.000
268	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	14	CREBBP(15), FYN(3), JAK1(1), JAK3(4), NMI(1), PIK3R1(10), PTK2B(3), STAT5A(2), STAT5B(1)	6135000	40	28	39	10	17	1	12	1	8	1	0.301	1.000	1.000
269	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(3), AKT2(1), AKT3(3), CDKN1A(1), ELK1(2), HRAS(1), MAP2K1(2), NGFR(1), PIK3CD(1), SOS1(5)	4126063	20	16	19	6	12	1	5	1	1	0	0.461	1.000	1.000
270	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	20	APAF1(3), BIRC2(2), BIRC3(1), CASP1(1), CASP10(1), CASP2(2), CASP3(1), CASP6(2), CASP9(1), DFFA(1), DFFB(1), GZMB(1), LMNB1(1), PRF1(1)	5263139	19	17	19	6	10	1	3	1	4	0	0.735	1.000	1.000
271	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(1), HMOX1(2), IL1A(2), IL6(1), JAK1(1), STAT1(2), STAT3(2), STAT5A(2)	3470674	13	10	13	7	9	0	3	0	1	0	0.816	1.000	1.000
272	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMB1(1), PSMB2(1), PSMB3(1), PSMB6(1), PSMC2(2), PSMC3(1), PSMD2(2), PSMD6(1)	4691828	11	9	11	4	4	2	2	1	2	0	0.778	1.000	1.000
273	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(1), CHPT1(1), HEMK1(1), LCMT1(4), LCMT2(1), METTL2B(1), PCYT1A(2), PCYT1B(1), PRMT2(1), PRMT5(1), PRMT6(1), PRMT7(3)	4042012	18	16	18	6	12	1	3	0	2	0	0.612	1.000	1.000
274	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CALM1(2), CALM3(1), CDKN1A(1), GNAQ(2), NFATC1(4), NFATC2(4), NFATC3(5), NFATC4(3), PLCG1(3), PPP3CA(1), PPP3CC(1), PRKCA(3), SP1(3), SP3(2), SYT1(2)	5774104	37	24	37	9	27	2	6	1	1	0	0.345	1.000	1.000
275	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(1), GUSB(4), UGP2(2), UGT1A1(2), UGT1A4(1), UGT1A5(1), UGT1A6(1), UGT2A1(2), UGT2A3(3), UGT2B10(3), UGT2B11(3), UGT2B15(5), UGT2B17(3), UGT2B4(1), UGT2B7(1), XYLB(1)	7956976	34	27	34	8	23	0	2	8	1	0	0.276	1.000	1.000
276	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(3), ACADS(3), ACAT1(2), ACAT2(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH5A1(1), ALDH9A1(2), EHHADH(1), GAD1(4), L2HGDH(1), PDHA1(1), PDHA2(4), PDHB(2), SDHB(1), SDS(1)	7484637	38	26	37	9	20	2	6	6	4	0	0.239	1.000	1.000
277	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(1), G6PD(1), GCLM(1), GSTA2(2), GSTA3(2), GSTA4(1), GSTM2(1), GSTM4(1), GSTT1(2), GSTT2(1), GSTZ1(1), MGST3(1), PGD(2)	5440784	17	16	17	9	9	1	5	0	2	0	0.818	1.000	1.000
278	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(1), CARS2(1), CDO1(2), GOT2(1), LDHAL6A(1), LDHAL6B(1), LDHC(3), SDS(1), SULT1B1(3), SULT1C4(1), SULT4A1(1)	3608770	16	14	16	5	12	0	3	1	0	0	0.541	1.000	1.000
279	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	19	CCNA1(2), CCND1(1), CDC25A(2), CDK2(1), CDKN1A(1), RBL1(3), TFDP1(2)	3925597	12	8	12	7	4	2	3	2	1	0	0.949	1.000	1.000
280	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	FUCA2(3), GLB1(4), HEXB(2), LCT(3), MANBA(2), NEU1(2)	4509828	16	14	16	9	6	2	5	1	2	0	0.924	1.000	1.000
281	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	14	CHUK(2), CREBBP(15), FADD(1), HDAC3(3), IKBKB(2), NFKB1(2), NFKBIA(2), RELA(7), RIPK1(2), TNFRSF1A(4), TNFRSF1B(2), TRAF6(1)	4938721	43	26	42	11	21	3	8	1	9	1	0.403	1.000	1.000
282	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	ELK1(2), EPOR(1), FOS(2), HRAS(1), JAK2(6), JUN(2), MAP2K1(2), MAPK3(1), MAPK8(1), PLCG1(3), SOS1(5), STAT5A(2), STAT5B(1)	6360634	29	23	29	9	13	2	9	1	3	1	0.539	1.000	1.000
283	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), EHHADH(1), SDS(1)	3542611	15	13	15	5	9	0	2	3	1	0	0.561	1.000	1.000
284	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(3), CCR2(1), CCR3(1), CCR4(2), CCR7(1), CD4(1), CXCR3(1), CXCR4(3), IFNG(1), IFNGR1(6), IFNGR2(3), IL12A(2), IL12B(2), IL12RB1(1), IL12RB2(2), IL18R1(2), IL4R(5), IL5(1), TGFB2(1), TGFB3(2)	5927664	41	34	40	13	20	5	6	1	9	0	0.417	1.000	1.000
285	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	B4GALT3(1), B4GALT5(1), DPAGT1(1), FUT8(3), MAN1A1(1), MAN1B1(3), MGAT2(1), MGAT3(3), MGAT5(2), RPN1(2), ST6GAL1(2)	5578702	20	16	20	9	11	1	5	0	3	0	0.799	1.000	1.000
286	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(1), ABCC2(3), ABCG2(2), BCHE(4), CES1(3), CES2(1), CYP3A5(2), UGT1A1(2), UGT1A4(1), UGT1A5(1), UGT1A6(1)	6622474	21	18	21	7	10	0	5	5	1	0	0.545	1.000	1.000
287	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(5), ACACB(6), ACAT1(2), ACAT2(1), ACOT12(1), ACSS1(3), ACSS2(2), AKR1B1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), DLAT(2), GLO1(1), GRHPR(1), LDHAL6A(1), LDHAL6B(1), LDHC(3), LDHD(1), MDH1(1), MDH2(1), ME1(1), ME2(3), PC(1), PCK2(1), PDHA1(1), PDHA2(4), PDHB(2), PKLR(3)	13542411	58	41	57	10	36	4	6	9	3	0	0.0273	1.000	1.000
288	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(1), ACTN2(2), CTNNA1(2), CTNNA2(4), CTNNB1(5), PTK2(2), PXN(2), VCL(3)	5666744	21	17	20	8	7	1	7	3	3	0	0.770	1.000	1.000
289	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	14	ATN1(4), CASP1(1), CASP3(1), GAPDH(1), INSR(4), ITCH(2), MAGI1(3), MAGI2(3), RERE(4), WWP2(4)	6521638	27	22	27	8	14	1	7	1	4	0	0.626	1.000	1.000
290	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(1), ALDOA(3), ALDOB(1), ALDOC(1), FPGT(2), GCK(2), GMDS(1), GMPPA(1), HK1(2), HK2(4), HK3(1), KHK(2), PFKFB1(1), PMM2(1)	7129965	23	19	23	8	14	2	4	1	2	0	0.450	1.000	1.000
291	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1R(1), C1S(1), C2(1), C3(6), C5(3), C6(5), C7(3), C8B(2), C9(1), MASP1(1)	5917088	24	17	24	9	13	3	5	1	2	0	0.784	1.000	1.000
292	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(2), ARFGAP3(1), ARFGEF2(6), CLTA(1), CLTB(1), COPA(2), GBF1(5), GPLD1(2), KDELR1(2), KDELR3(2)	4728569	24	18	24	8	17	0	3	2	2	0	0.632	1.000	1.000
293	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(1), ADH1B(2), ADH4(1), ADH6(1), ADH7(1), ADHFE1(1), DHRS1(1), DHRS3(2), DHRSX(4), ESCO1(1), ESCO2(1), NAT6(1), PNPLA3(1), SH3GLB1(2)	7189961	20	18	20	6	10	0	5	2	3	0	0.624	1.000	1.000
294	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	CA14(3), CA2(1), CA4(1), CA6(2), CA7(1), CA8(1), CPS1(1), GLS2(2), GLUD1(2), GLUL(1), HAL(1)	5488607	16	14	16	7	9	0	2	3	2	0	0.834	1.000	1.000
295	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(3), ALDOB(1), ALDOC(1), GOT2(1), GPT2(2), MDH1(1), MDH2(1), ME1(1), ME2(3), PGK1(1), PKLR(3), TKT(1)	5215091	19	16	19	8	8	2	6	1	2	0	0.730	1.000	1.000
296	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), AOC2(1), AOC3(3), ASPA(1), DDC(2), HAL(1), HDC(2), MAOA(1), MAOB(3), PRPS2(2)	7103244	29	25	29	9	19	0	5	4	1	0	0.436	1.000	1.000
297	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ACADM(4), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), AOC2(1), AOC3(3), DPYD(3), DPYS(1), EHHADH(1), GAD1(4), HIBCH(1), SMS(1), SRM(1)	7731074	29	19	29	9	15	1	3	5	5	0	0.491	1.000	1.000
298	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA2(1), ACAD8(1), ADH1B(2), ADH4(1), ADH6(1), ADH7(1), ADHFE1(1), AKR1C4(2), AKR1D1(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), BAAT(4), CEL(3), CYP27A1(3), CYP7A1(2), HSD3B7(1), LIPA(1), RDH13(1), SLC27A5(7), SOAT2(2)	9246158	45	33	45	12	20	2	15	3	5	0	0.243	1.000	1.000
299	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(1), CSF1R(2), EGF(1), EGFR(7), MET(2), PDGFRA(2), PRKCA(3), SH3GLB1(2), SH3KBP1(2)	5676647	22	17	22	7	14	0	6	0	2	0	0.572	1.000	1.000
300	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1B(2), ADH4(1), ADH6(1), ADH7(1), ADHFE1(1), ALDH1A3(2), ALDH3A1(1), AOC2(1), AOC3(3), AOX1(3), DBH(1), DCT(2), DDC(2), FAH(3), GOT2(1), GSTZ1(1), HGD(2), HPD(2), MAOA(1), MAOB(3), TAT(3), TH(2), TPO(6), TYR(2)	9207084	47	32	47	11	28	1	11	3	4	0	0.118	1.000	1.000
301	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	FUCA2(3), GLB1(4), HEXB(2), LCT(3), MAN2B1(4), MAN2B2(2), MANBA(2), NEU1(2)	5616177	22	17	22	9	10	2	5	3	2	0	0.725	1.000	1.000
302	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHA4(3), EPHB1(2), FYN(3), ITGA1(3), ITGB1(2), L1CAM(5), RAP1B(1)	4593801	20	17	20	9	9	0	10	0	1	0	0.858	1.000	1.000
303	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), AMDHD1(2), AOC2(1), AOC3(3), ASPA(1), CARM1(1), DDC(2), FTCD(3), HAL(1), HARS2(1), HDC(2), HEMK1(1), LCMT1(4), LCMT2(1), MAOA(1), MAOB(3), METTL2B(1), PRMT2(1), PRMT5(1), PRMT6(1), PRMT7(3), PRPS2(2), UROC1(7)	11531049	52	42	52	12	27	1	14	4	6	0	0.108	1.000	1.000
304	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), CYP2C19(1), CYP2C9(3), DHRS1(1), DHRS3(2), DHRSX(4), EHHADH(1), ESCO1(1), ESCO2(1), NAT6(1), PNPLA3(1), SH3GLB1(2)	8928809	27	21	27	7	15	0	5	5	2	0	0.408	1.000	1.000
305	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(1), EGFR(7), MAP2K1(2), MAP3K1(4), NCOR2(6), RXRA(1), THRA(1)	5119940	22	17	22	8	10	0	10	1	1	0	0.679	1.000	1.000
306	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	BHMT(1), CBS(1), DNMT1(3), DNMT3A(2), MARS(2), MARS2(2), MAT1A(1), MTR(2)	5133569	14	12	14	9	8	0	3	2	1	0	0.963	1.000	1.000
307	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	GALNS(2), GLB1(4), GNS(3), GUSB(4), HEXB(2), HGSNAT(1), HPSE2(2), HYAL1(1), HYAL2(1), IDS(8), LCT(3), NAGLU(1), SPAM1(1)	6026095	33	23	33	10	18	3	7	2	3	0	0.382	1.000	1.000
308	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(2), CALM3(1), CAMK1(2), CAMK2A(3), CAMK2B(1), CAMK2D(2), CAMK4(2), ESRRA(1), HDAC5(2), MEF2A(1), MEF2B(1), MEF2C(1), MEF2D(3), PPARA(1), PPP3CA(1), PPP3CC(1), SYT1(2)	6139147	27	18	27	9	15	3	3	4	2	0	0.608	1.000	1.000
309	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(3), MAP2(10), PRKAG1(1), PRKAR2A(1), PRKCE(1)	5273842	16	14	16	7	9	0	5	1	1	0	0.952	1.000	1.000
310	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(5), ACACB(6), FASN(4), MCAT(1), OLAH(1), OXSM(1)	4713290	18	18	18	8	13	0	2	2	1	0	0.759	1.000	1.000
311	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AMD1(5), BHMT(1), CBS(1), DNMT1(3), DNMT3A(2), MARS(2), MARS2(2), MAT1A(1), MTR(2), SRM(1), TAT(3)	6096503	23	18	23	9	12	0	7	2	2	0	0.735	1.000	1.000
312	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL22RA1(1), JAK1(1), JAK2(6), JAK3(4), SOCS3(6), STAT1(2), STAT3(2), STAT5A(2), STAT5B(1), TYK2(9)	5389356	34	27	34	10	18	2	5	2	5	2	0.378	1.000	1.000
313	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	25	AKT1(3), APC(7), CCND1(1), CD14(3), CTNNB1(5), FZD1(1), GJA1(2), GNAI1(1), IRAK1(3), LEF1(1), LY96(2), NFKB1(2), PDPK1(2), PIK3R1(10), RELA(7), TLR4(2), TOLLIP(1), WNT1(1)	8140287	54	32	51	11	30	4	9	5	6	0	0.215	1.000	1.000
314	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	21	CRK(1), CXCR4(3), GNAI1(1), GNAQ(2), GNB1(1), GNGT1(1), HRAS(1), MAP2K1(2), MAPK3(1), NFKB1(2), PIK3C2G(5), PIK3R1(10), PLCG1(3), PRKCA(3), PTK2(2), PTK2B(3), PXN(2), RELA(7)	7319634	50	28	50	12	23	3	12	6	6	0	0.282	1.000	1.000
315	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(1), AGT(2), AGTR1(1), ANPEP(1), CPA3(1), CTSA(1), CTSG(1), ENPEP(5), LNPEP(1), MAS1(2), MME(2), NLN(4), REN(1), THOP1(4)	6158481	27	21	27	9	15	2	7	1	2	0	0.532	1.000	1.000
316	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(5), ACAT1(2), ACAT2(1), AKR1B1(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), DLAT(2), GLO1(1), GRHPR(1), LDHC(3), LDHD(1), MDH1(1), MDH2(1), ME1(1), ME2(3), PC(1), PDHA1(1), PDHA2(4), PDHB(2), PKLR(3)	10697525	47	34	46	10	28	4	5	7	3	0	0.144	1.000	1.000
317	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(1), GUSB(4), UCHL1(1), UGT1A1(2), UGT1A4(1), UGT1A5(1), UGT1A6(1), UGT2B15(5), UGT2B4(1)	5129046	17	13	17	6	12	0	0	4	1	0	0.615	1.000	1.000
318	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(2), ACP5(1), ACPT(5), ALPI(3), ALPL(1), ALPP(2), ALPPL2(1), CYP19A1(1), CYP1A1(1), CYP1A2(1), CYP2A13(1), CYP2A6(2), CYP2A7(5), CYP2C18(3), CYP2C19(1), CYP2C9(3), CYP2E1(1), CYP2F1(1), CYP2J2(2), CYP3A5(2), CYP3A7(1), PON1(1)	8544552	41	30	41	12	29	1	10	1	0	0	0.148	1.000	1.000
319	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	24	ARNT(3), EIF2B2(2), EIF2B4(2), EIF2B5(1), EIF2S1(3), EIF2S2(2), ELAVL1(2), FLT1(7), FLT4(7), HIF1A(5), HRAS(1), KDR(2), NOS3(6), PIK3R1(10), PLCG1(3), PRKCA(3), PTK2(2), PXN(2)	9426492	63	34	63	14	34	2	14	3	10	0	0.147	1.000	1.000
320	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(1), ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), ATP7A(3), ATP7B(5), COX10(1), COX4I1(1), COX5A(2), COX6A1(1), COX7A2(1), COX8A(1), NDUFA1(1), NDUFA11(1), NDUFA5(1), NDUFA8(1), NDUFB7(2), NDUFS1(1), NDUFS2(1), NDUFV1(3), SDHA(4), SDHB(1), SHMT1(2), UQCRB(2), UQCRC1(1), UQCRFS1(1)	11285860	52	36	52	12	20	2	14	2	14	0	0.166	1.000	1.000
321	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	22	GHR(6), HRAS(1), INSR(4), IRS1(2), JAK2(6), MAP2K1(2), MAPK3(1), PIK3R1(10), PLCG1(3), PRKCA(3), RPS6KA1(1), SOS1(5), STAT5A(2), STAT5B(1)	8741002	47	30	47	11	22	4	11	3	6	1	0.212	1.000	1.000
322	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(2), ACAT2(1), DHRS1(1), DHRS3(2), DHRSX(4), EHHADH(1), ESCO1(1), ESCO2(1), GCDH(2), NAT6(1), PNPLA3(1), SH3GLB1(2)	7504907	19	16	19	6	8	1	5	3	2	0	0.657	1.000	1.000
323	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(3), ALDOB(1), ALDOC(1), G6PD(1), GPI(3), H6PD(2), PGD(2), PGM3(1), PRPS2(2), TKT(1)	5745448	17	15	17	7	7	2	6	1	1	0	0.663	1.000	1.000
324	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(1), G6PC(3), GAA(4), GALK1(2), GALK2(1), GALT(2), GANAB(4), GCK(2), GLA(1), GLB1(4), HK1(2), HK2(4), HK3(1), LCT(3), MGAM(12), PGM3(1)	9518121	47	35	46	14	23	5	7	3	9	0	0.299	1.000	1.000
325	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(1), ACADM(4), ACADS(3), ACADVL(2), ACAT1(2), ACAT2(1), ACOX1(1), ACOX3(2), ACSL1(1), ACSL3(2), ACSL4(5), ACSL5(2), ACSL6(1), ADH1B(2), ADH4(1), ADH6(1), ADH7(1), ADHFE1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), CPT1A(4), CPT1B(3), CPT1C(1), CPT2(1), CYP4A22(2), EHHADH(1), GCDH(2), HADH(1), HSD17B10(1), HSD17B4(10)	14239233	68	38	68	16	32	4	13	8	11	0	0.113	1.000	1.000
326	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	FUCA2(3), GALNS(2), GLB1(4), GNS(3), GUSB(4), HEXB(2), HGSNAT(1), HPSE2(2), HYAL1(1), HYAL2(1), IDS(8), LCT(3), MAN2B1(4), MAN2B2(2), MANBA(2), NAGLU(1), NEU1(2), SPAM1(1)	9824329	46	27	46	13	26	3	9	4	4	0	0.259	1.000	1.000
327	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	DLAT(2), FH(1), IDH3A(2), IDH3B(1), IDH3G(1), MDH1(1), MDH2(1), OGDH(4), PC(1), PDHA1(1), PDHA2(4), PDHB(2), PDHX(2), PDK1(3), PDK2(1), PDK3(1), PDK4(1), PDP2(1), SDHA(4), SDHB(1), SDHD(1), SUCLA2(1), SUCLG1(1), SUCLG2(1)	8378522	39	33	38	10	18	1	9	2	9	0	0.321	1.000	1.000
328	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(5), POLA2(1), POLB(1), POLD1(3), POLD2(1), POLD3(1), POLE(7), POLG(3), POLG2(2), POLI(1), POLK(4), POLL(1), POLM(4), POLQ(13), PRIM1(1), REV1(2), REV3L(3), RFC5(2)	12101557	55	32	55	10	29	1	9	4	12	0	0.186	1.000	1.000
329	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(1), AMY2A(3), AMY2B(3), ENPP1(2), ENPP3(5), G6PC(3), GAA(4), GANAB(4), GCK(2), GPI(3), GUSB(4), GYS1(2), GYS2(2), HK1(2), HK2(4), HK3(1), MGAM(12), PGM3(1), PYGB(3), PYGM(1), RNPC3(3), SI(12), UCHL1(1), UGT1A1(2), UGT1A4(1), UGT1A5(1), UGT1A6(1), UGT2B15(5), UGT2B4(1), UXS1(2)	16838795	91	62	91	22	42	5	20	12	12	0	0.176	1.000	1.000
330	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	39	ALK(3), AR(8), ESR1(1), ESRRA(1), HNF4A(3), NPM1(1), NR0B1(2), NR1D1(2), NR1D2(2), NR1H2(4), NR1H3(3), NR1I2(2), NR2C2(1), NR2E1(4), NR2F2(3), NR3C1(4), NR4A1(1), NR5A2(2), PGR(2), PPARA(1), PPARD(2), PPARG(1), RARB(5), RARG(5), ROR1(1), RORA(1), RORC(1), RXRA(1), THRA(1), VDR(1)	11816018	69	44	68	18	42	0	16	6	5	0	0.169	1.000	1.000
331	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(1), ALAS2(2), AOC2(1), AOC3(3), BHMT(1), CBS(1), CHDH(1), CHKA(2), CHKB(3), DAO(1), DMGDH(1), GARS(1), GCAT(3), GLDC(3), GNMT(1), HSD3B7(1), MAOA(1), MAOB(3), PEMT(1), PSPH(1), RDH13(1), SARDH(2), SARS(1), SARS2(3), SDS(1), SHMT1(2), SHMT2(1), TARS(2), TARS2(3)	12578325	48	30	48	12	30	1	11	3	3	0	0.150	1.000	1.000
332	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	53	AKR1C4(2), AKR1D1(2), ARSE(1), CARM1(1), CYP11B1(1), CYP11B2(3), CYP19A1(1), HEMK1(1), HSD11B2(1), HSD17B12(1), HSD17B7(2), HSD3B1(2), HSD3B2(1), LCMT1(4), LCMT2(1), METTL2B(1), PRMT2(1), PRMT5(1), PRMT6(1), PRMT7(3), STS(2), SULT1E1(1), SULT2B1(3), UGT1A1(2), UGT1A4(1), UGT1A5(1), UGT1A6(1), UGT2A1(2), UGT2A3(3), UGT2B10(3), UGT2B11(3), UGT2B15(5), UGT2B17(3), UGT2B4(1), UGT2B7(1)	14461835	63	50	63	16	36	3	9	10	5	0	0.184	1.000	1.000
333	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(1), ALAS2(2), AOC2(1), AOC3(3), BHMT(1), CBS(1), CHDH(1), CHKA(2), CHKB(3), CPT1B(3), DAO(1), DMGDH(1), GARS(1), GCAT(3), GLDC(3), MAOA(1), MAOB(3), PEMT(1), PLCB2(2), PLCG1(3), PLCG2(4), PSPH(1), SARDH(2), SARS(1), SHMT1(2), SHMT2(1), TARS(2)	12355700	50	31	50	13	28	2	12	5	3	0	0.193	1.000	1.000
334	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	24	ADCY1(4), AKT1(3), CAMK2A(3), CAMK2B(1), CAMK2D(2), CREB1(2), GNAS(6), HRAS(1), MAPK3(1), PIK3R1(10), PRKAR2A(1), PRKCA(3), RAC1(1), RPS6KA1(1), RPS6KA5(2), SOS1(5)	7564029	46	29	45	12	25	2	12	3	4	0	0.392	1.000	1.000
335	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1B(2), ADH4(1), ADH6(1), ADH7(1), ADHFE1(1), AGPAT2(1), AGPAT4(1), AKR1A1(1), AKR1B1(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), CEL(3), DGAT1(2), DGKA(3), DGKB(1), DGKE(1), DGKG(3), DGKH(2), DGKQ(1), DGKZ(5), GK(2), GLA(1), GLB1(4), LCT(3), LIPC(2), LIPF(1), LIPG(2), LPL(2), PNLIP(3), PNLIPRP1(3), PNLIPRP2(2), PPAP2B(4)	14131257	73	49	73	20	34	3	20	4	12	0	0.197	1.000	1.000
336	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(3), AKT2(1), AKT3(3), IL4R(5), INPP5D(4), JAK1(1), JAK2(6), JAK3(4), PPP1R13B(2), RPS6KB1(1), SERPINA4(2), SOS1(5), SOS2(5), STAT6(3), TYK2(9)	10083392	54	35	52	14	28	3	11	4	6	2	0.295	1.000	1.000
337	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	26	BRAF(2), CPEB1(1), EGFR(7), ERBB2(11), ERBB4(4), ETS2(1), ETV6(2), FMN2(9), MAP2K1(2), MAPK3(1), NOTCH1(14), NOTCH2(7), NOTCH3(7), NOTCH4(6), PIWIL1(3), PIWIL2(2), PIWIL3(5), PIWIL4(3), SOS1(5), SOS2(5), SPIRE1(1), SPIRE2(3)	14236205	101	58	97	23	52	4	27	6	12	0	0.137	1.000	1.000
338	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1B(2), ADH4(1), ADH6(1), ADH7(1), ADHFE1(1), AKR1A1(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), ALDOA(3), ALDOB(1), ALDOC(1), DLAT(2), ENO1(3), ENO3(4), G6PC(3), GAPDH(1), GCK(2), GPI(3), HK1(2), HK2(4), HK3(1), LDHC(3), PDHA1(1), PDHA2(4), PDHB(2), PGAM1(1), PGK1(1), PGM3(1), PKLR(3)	14232734	66	42	65	17	37	3	11	6	9	0	0.135	1.000	1.000
339	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1B(2), ADH4(1), ADH6(1), ADH7(1), ADHFE1(1), AKR1A1(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), ALDOA(3), ALDOB(1), ALDOC(1), DLAT(2), ENO1(3), ENO3(4), G6PC(3), GAPDH(1), GCK(2), GPI(3), HK1(2), HK2(4), HK3(1), LDHC(3), PDHA1(1), PDHA2(4), PDHB(2), PGAM1(1), PGK1(1), PGM3(1), PKLR(3)	14232734	66	42	65	17	37	3	11	6	9	0	0.135	1.000	1.000
340	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(4), CALM1(2), CALM3(1), CREB1(2), ELK1(2), FOS(2), GNAI1(1), GNAQ(2), GNAS(6), GNB1(1), GNGT1(1), HRAS(1), JUN(2), MAP2K1(2), MAPK3(1), NFATC1(4), NFATC2(4), NFATC3(5), NFATC4(3), PLCG1(3), PPP3CA(1), PPP3CC(1), PRKAR2A(1), PRKCA(3), RPS6KA3(2), SYT1(2)	9832491	59	38	59	15	38	2	13	3	3	0	0.267	1.000	1.000
341	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	189	ACTB(2), ACTG1(5), ACTN1(1), ACTN2(2), ACTN4(2), AKT1(3), AKT2(1), AKT3(3), ARHGAP5(4), BAD(2), BIRC2(2), BIRC3(1), BRAF(2), CAV2(1), CCND1(1), CDC42(1), COL11A1(11), COL11A2(5), COL1A1(2), COL1A2(3), COL2A1(7), COL3A1(5), COL4A1(4), COL4A2(4), COL4A4(2), COL4A6(4), COL5A1(6), COL5A2(6), COL5A3(3), COL6A1(3), COL6A2(4), COL6A3(10), COL6A6(6), COMP(3), CRK(1), CTNNB1(5), DIAPH1(1), DOCK1(4), EGF(1), EGFR(7), ELK1(2), ERBB2(11), FARP2(3), FIGF(1), FLNA(10), FLNB(7), FLNC(11), FLT1(7), FN1(5), FYN(3), HGF(5), HRAS(1), IGF1R(3), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(3), ITGA2B(1), ITGA3(1), ITGA4(6), ITGA5(2), ITGA7(4), ITGA8(5), ITGA9(2), ITGAV(1), ITGB1(2), ITGB3(3), ITGB4(7), ITGB5(1), ITGB6(2), ITGB7(1), ITGB8(2), JUN(2), KDR(2), LAMA1(7), LAMA2(11), LAMA3(4), LAMA4(5), LAMA5(8), LAMB1(2), LAMB2(6), LAMB3(4), LAMB4(1), LAMC1(4), LAMC2(3), LAMC3(4), MAP2K1(2), MAPK3(1), MAPK8(1), MAPK9(4), MET(2), MYL5(1), MYL9(1), MYLK(2), MYLPF(1), PAK1(1), PAK2(1), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PARVB(2), PDGFC(1), PDGFRA(2), PDGFRB(2), PDPK1(2), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(10), PIK3R3(4), PIP5K1C(3), PPP1CB(2), PPP1CC(1), PPP1R12A(7), PRKCA(3), PRKCG(1), PTK2(2), PXN(2), RAC1(1), RAC2(1), RAC3(1), RAP1A(1), RAP1B(1), RAPGEF1(4), RELN(7), RHOA(2), ROCK1(3), ROCK2(4), SHC2(3), SHC3(1), SOS1(5), SOS2(5), SPP1(3), THBS1(2), THBS2(2), THBS3(2), THBS4(1), TLN1(3), TLN2(1), TNC(9), TNN(1), TNXB(7), VASP(1), VAV1(2), VAV2(3), VAV3(3), VCL(3), VEGFA(1), VEGFC(4), VWF(6), ZYX(1)	107110725	490	135	482	180	257	22	119	31	61	0	0.985	1.000	1.000
342	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	244	ACVR1B(2), ACVR1C(1), AKT1(3), AKT2(1), AKT3(3), ARRB1(2), ATF2(2), ATF4(2), BRAF(2), CACNA1A(4), CACNA1B(9), CACNA1C(9), CACNA1D(4), CACNA1E(6), CACNA1F(6), CACNA1G(4), CACNA1H(8), CACNA1I(5), CACNA1S(3), CACNA2D1(3), CACNA2D2(3), CACNA2D3(3), CACNA2D4(3), CACNB1(2), CACNB2(2), CACNB3(2), CACNB4(7), CACNG3(1), CACNG5(1), CACNG6(1), CACNG7(3), CACNG8(1), CASP3(1), CD14(3), CDC25B(4), CDC42(1), CHUK(2), CRK(1), DAXX(2), DDIT3(1), DUSP1(1), DUSP10(1), DUSP16(2), DUSP5(2), DUSP7(2), DUSP8(1), DUSP9(1), EGF(1), EGFR(7), ELK1(2), ELK4(3), FAS(5), FASLG(1), FGF1(1), FGF11(1), FGF14(2), FGF17(1), FGF18(1), FGF2(1), FGF21(1), FGF3(1), FGF4(1), FGF8(1), FGF9(1), FGFR1(1), FGFR2(2), FGFR4(2), FLNA(10), FLNB(7), FLNC(11), FOS(2), GADD45B(1), GNA12(2), HRAS(1), IKBKB(2), IL1A(2), IL1R1(2), IL1R2(2), JUN(2), MAP2K1(2), MAP2K3(2), MAP2K7(1), MAP3K1(4), MAP3K10(2), MAP3K12(3), MAP3K13(1), MAP3K2(1), MAP3K3(1), MAP3K4(6), MAP3K5(11), MAP3K6(4), MAP3K8(1), MAP4K1(3), MAP4K2(2), MAP4K3(1), MAP4K4(3), MAPK11(2), MAPK13(1), MAPK3(1), MAPK7(2), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(2), MAPK9(4), MAPKAPK2(2), MAPKAPK3(1), MAPKAPK5(1), MAPT(2), MAX(2), MEF2C(1), MKNK1(1), MKNK2(2), MRAS(1), MYC(1), NF1(10), NFATC2(4), NFATC4(3), NFKB1(2), NFKB2(1), NR4A1(1), NRAS(1), NTRK2(1), PAK1(1), PAK2(1), PDGFRA(2), PDGFRB(2), PLA2G12A(1), PLA2G12B(3), PLA2G2D(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PPM1B(1), PPP3CA(1), PPP3CC(1), PPP5C(4), PRKACA(2), PRKCA(3), PRKCG(1), PTPN5(1), PTPRR(1), RAC1(1), RAC2(1), RAC3(1), RAP1A(1), RAP1B(1), RAPGEF2(4), RASA1(4), RASA2(6), RASGRF1(1), RASGRF2(1), RASGRP1(1), RASGRP2(5), RASGRP4(5), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA4(1), RPS6KA5(2), RPS6KA6(6), SOS1(5), SOS2(5), STK3(2), STK4(2), STMN1(1), TAOK1(2), TAOK2(6), TAOK3(3), TGFB2(1), TGFB3(2), TGFBR1(1), TGFBR2(5), TNFRSF1A(4), TP53(12), TRAF2(1), TRAF6(1), ZAK(5)	85049011	449	133	444	158	247	19	113	25	43	2	0.641	1.000	1.000
343	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(4), ADCY2(3), ADCY3(1), ADCY4(4), ADCY7(2), ADCY8(4), ADCY9(8), ADRA1A(3), ADRA1B(2), ADRA1D(1), ADRB2(2), AGTR1(1), ATP2A1(3), ATP2A2(3), ATP2A3(3), ATP2B1(3), ATP2B2(5), ATP2B3(3), ATP2B4(4), AVPR1A(1), AVPR1B(2), BST1(4), CACNA1A(4), CACNA1B(9), CACNA1C(9), CACNA1D(4), CACNA1E(6), CACNA1F(6), CACNA1G(4), CACNA1H(8), CACNA1I(5), CACNA1S(3), CALM1(2), CALM3(1), CALML6(1), CAMK2A(3), CAMK2B(1), CAMK2D(2), CAMK4(2), CCKAR(1), CCKBR(1), CHRM1(1), CHRM2(3), CHRM3(3), CHRM5(1), CHRNA7(1), CYSLTR1(2), CYSLTR2(1), EDNRA(1), EDNRB(2), EGFR(7), ERBB2(11), ERBB3(12), ERBB4(4), F2R(1), GNA11(2), GNA15(4), GNAL(2), GNAQ(2), GNAS(6), GRIN2A(4), GRIN2D(3), GRM1(3), GRM5(5), GRPR(4), HRH1(2), HRH2(1), HTR2B(2), HTR2C(2), HTR4(1), HTR5A(1), HTR6(3), HTR7(2), ITPKA(1), ITPKB(1), ITPR1(8), ITPR2(5), ITPR3(2), LHCGR(1), MYLK(2), NOS1(2), NOS3(6), NTSR1(1), OXTR(3), P2RX1(1), P2RX2(3), PDE1A(3), PDE1B(2), PDE1C(6), PDGFRA(2), PDGFRB(2), PHKA1(4), PHKA2(7), PHKB(3), PHKG2(1), PLCB1(10), PLCB2(2), PLCB3(2), PLCB4(1), PLCD1(2), PLCD3(3), PLCD4(2), PLCE1(9), PLCG1(3), PLCG2(4), PLCZ1(3), PPID(2), PPP3CA(1), PPP3CC(1), PRKACA(2), PRKCA(3), PRKCG(1), PTAFR(1), PTGER3(2), PTGFR(1), PTK2B(3), RYR1(10), RYR2(26), RYR3(11), SLC25A5(5), SLC8A1(1), SLC8A2(1), SPHK1(1), SPHK2(1), TACR1(1), TACR2(1), TBXA2R(1), TRPC1(5), VDAC1(1), VDAC2(1)	80199441	427	132	420	180	218	17	125	32	35	0	0.834	1.000	1.000
344	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(2), ACTG1(5), COL11A1(11), COL11A2(5), COL17A1(4), COL1A1(2), COL1A2(3), COL2A1(7), COL3A1(5), COL4A1(4), COL4A2(4), COL4A4(2), COL4A6(4), COL5A1(6), COL5A2(6), COL5A3(3), COL6A1(3), COL6A2(4), COL6A3(10), COL6A6(6), COMP(3), DSC1(1), DSC2(1), DSG1(2), DSG2(1), DSG3(8), DSG4(5), FN1(5), GJA1(2), GJA10(2), GJA5(1), GJA8(1), GJA9(2), GJB1(1), GJB5(1), GJB6(1), GJC1(1), GJC2(2), GJD2(2), INA(2), ITGB4(7), KRT1(6), KRT10(3), KRT13(1), KRT15(3), KRT16(1), KRT18(2), KRT2(2), KRT20(2), KRT24(2), KRT25(1), KRT27(1), KRT28(4), KRT31(2), KRT32(2), KRT33A(1), KRT34(1), KRT35(2), KRT36(1), KRT37(1), KRT38(2), KRT39(1), KRT4(1), KRT40(2), KRT5(2), KRT6A(2), KRT6B(5), KRT7(1), KRT71(2), KRT74(1), KRT75(1), KRT76(2), KRT79(2), KRT81(1), KRT82(1), KRT83(1), KRT84(2), KRT85(4), KRT86(3), KRT9(1), LAMA1(7), LAMA2(11), LAMA3(4), LAMA4(5), LAMA5(8), LAMB1(2), LAMB2(6), LAMB3(4), LAMB4(1), LAMC1(4), LAMC2(3), LAMC3(4), LMNB1(1), NES(3), PRPH(1), RELN(7), SPP1(3), THBS1(2), THBS2(2), THBS3(2), THBS4(1), TNC(9), TNN(1), TNXB(7), VIM(1), VWF(6)	72000831	327	118	326	118	179	13	71	27	37	0	0.957	1.000	1.000
345	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	237	ADCYAP1R1(3), ADORA1(1), ADORA3(3), ADRA1A(3), ADRA1B(2), ADRA2C(1), ADRB2(2), AGTR1(1), AVPR1A(1), AVPR1B(2), AVPR2(2), BRS3(3), C5AR1(2), CALCRL(1), CCKAR(1), CCKBR(1), CGA(1), CHRM1(1), CHRM2(3), CHRM3(3), CHRM4(1), CHRM5(1), CNR1(1), CNR2(1), CRHR1(2), CRHR2(2), CTSG(1), CYSLTR1(2), CYSLTR2(1), DRD3(2), EDNRA(1), EDNRB(2), F2R(1), F2RL2(1), F2RL3(2), FPR1(1), FSHR(2), GABBR1(5), GABBR2(2), GABRA1(1), GABRA2(2), GABRA4(1), GABRA5(1), GABRA6(1), GABRB1(2), GABRB2(1), GABRB3(4), GABRD(3), GABRE(1), GABRG1(3), GABRG2(3), GABRG3(4), GABRP(1), GABRQ(1), GABRR1(3), GALR2(1), GH2(1), GHR(6), GHSR(2), GIPR(3), GLP1R(1), GLRA1(1), GLRA2(2), GLRA3(3), GLRB(2), GPR156(2), GPR35(1), GPR50(2), GPR63(2), GPR83(1), GRIA1(4), GRIA2(2), GRIA3(6), GRIA4(2), GRID1(3), GRID2(2), GRIK1(4), GRIK3(2), GRIK4(2), GRIK5(5), GRIN2A(4), GRIN2B(3), GRIN2D(3), GRIN3A(3), GRIN3B(1), GRM1(3), GRM2(2), GRM3(2), GRM4(1), GRM5(5), GRM6(3), GRM7(3), GRM8(6), GRPR(4), GZMA(1), HCRTR1(1), HCRTR2(2), HRH1(2), HRH2(1), HRH4(2), HTR1A(4), HTR1B(2), HTR1D(1), HTR1F(2), HTR2B(2), HTR2C(2), HTR4(1), HTR5A(1), HTR6(3), HTR7(2), LEP(1), LEPR(8), LHCGR(1), MAS1(2), MC1R(1), MC2R(1), MC3R(1), MC5R(2), MCHR1(1), MCHR2(3), MLNR(3), MTNR1A(1), MTNR1B(2), NPBWR1(1), NPY1R(2), NPY2R(2), NPY5R(4), NR3C1(4), NTSR1(1), OPRL1(1), OPRM1(3), OXTR(3), P2RX1(1), P2RX2(3), P2RY1(1), P2RY10(1), P2RY13(3), P2RY14(1), P2RY4(3), P2RY8(2), PARD3(8), PRL(3), PRLHR(1), PRLR(1), PRSS1(2), PRSS3(2), PTAFR(1), PTGDR(2), PTGER3(2), PTGER4(2), PTGFR(1), PTH2R(1), RXFP1(3), RXFP2(2), SCTR(1), SSTR5(1), TAAR1(1), TAAR2(2), TAAR5(2), TACR1(1), TACR2(1), TBXA2R(1), THRA(1), VIPR2(1)	63414992	340	118	340	158	163	23	101	28	25	0	0.844	1.000	1.000
346	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	196	ABI2(1), ACTN1(1), ACTN2(2), ACTN4(2), APC(7), ARAF(1), ARHGEF1(1), ARHGEF12(6), ARHGEF4(5), ARHGEF6(1), ARHGEF7(4), ARPC1A(2), ARPC2(3), BRAF(2), CD14(3), CDC42(1), CHRM1(1), CHRM2(3), CHRM3(3), CHRM4(1), CHRM5(1), CRK(1), CYFIP1(5), DIAPH1(1), DIAPH2(4), DIAPH3(3), DOCK1(4), EGF(1), EGFR(7), EZR(6), F2R(1), FGD1(2), FGD3(4), FGF1(1), FGF11(1), FGF14(2), FGF17(1), FGF18(1), FGF2(1), FGF21(1), FGF3(1), FGF4(1), FGF8(1), FGF9(1), FGFR1(1), FGFR2(2), FGFR4(2), FN1(5), GNA12(2), GNA13(3), GSN(2), HRAS(1), IQGAP1(10), IQGAP2(4), IQGAP3(4), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(3), ITGA2B(1), ITGA3(1), ITGA4(6), ITGA5(2), ITGA7(4), ITGA8(5), ITGA9(2), ITGAD(1), ITGAE(3), ITGAL(4), ITGAM(4), ITGAV(1), ITGAX(3), ITGB1(2), ITGB3(3), ITGB4(7), ITGB5(1), ITGB6(2), ITGB7(1), ITGB8(2), LIMK1(4), LIMK2(2), MAP2K1(2), MAPK3(1), MRAS(1), MSN(2), MYH10(9), MYH14(3), MYH9(16), MYL5(1), MYL9(1), MYLK(2), MYLPF(1), NCKAP1(3), NCKAP1L(2), NRAS(1), PAK1(1), PAK2(1), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PDGFRA(2), PDGFRB(2), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(10), PIK3R3(4), PIP4K2A(1), PIP5K1A(1), PIP5K1B(1), PIP5K1C(3), PPP1CB(2), PPP1CC(1), PPP1R12A(7), PPP1R12B(3), PTK2(2), PXN(2), RAC1(1), RAC2(1), RAC3(1), RDX(2), RHOA(2), ROCK1(3), ROCK2(4), SCIN(1), SLC9A1(4), SOS1(5), SOS2(5), SSH1(1), SSH2(4), SSH3(2), TIAM1(4), TIAM2(4), TMSB4X(1), VAV1(2), VAV2(3), VAV3(3), VCL(3), WASF1(3), WASF2(2), WASL(4)	80691900	375	117	374	154	207	12	85	15	55	1	0.992	1.000	1.000
347	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	125	ABL1(8), ABLIM1(1), ABLIM2(1), ABLIM3(1), ARHGEF12(6), CDC42(1), CXCR4(3), DCC(9), DPYSL2(1), DPYSL5(5), EFNB2(1), EPHA1(1), EPHA2(10), EPHA3(5), EPHA4(3), EPHA5(6), EPHA7(3), EPHA8(2), EPHB1(2), EPHB2(3), EPHB3(4), EPHB4(1), EPHB6(4), FES(2), FYN(3), GNAI1(1), GNAI2(1), GNAI3(3), HRAS(1), ITGB1(2), L1CAM(5), LIMK1(4), LIMK2(2), LRRC4C(2), MAPK3(1), MET(2), NCK1(2), NFAT5(5), NFATC1(4), NFATC2(4), NFATC3(5), NFATC4(3), NGEF(1), NRAS(1), NRP1(3), NTN1(1), NTN4(2), NTNG1(3), PAK1(1), PAK2(1), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PLXNA1(5), PLXNA2(4), PLXNA3(10), PLXNB1(5), PLXNB2(6), PLXNB3(4), PLXNC1(6), PPP3CA(1), PPP3CC(1), PTK2(2), RAC1(1), RAC2(1), RAC3(1), RASA1(4), RGS3(8), RHOA(2), RHOD(1), RND1(1), ROBO1(8), ROBO2(4), ROBO3(4), ROCK1(3), ROCK2(4), SEMA3A(3), SEMA3D(1), SEMA3E(2), SEMA3F(1), SEMA3G(1), SEMA4A(4), SEMA4B(7), SEMA4C(1), SEMA4F(3), SEMA4G(1), SEMA5A(2), SEMA5B(2), SEMA6A(3), SEMA6B(1), SEMA6C(3), SEMA6D(3), SLIT1(2), SLIT2(6), SLIT3(5), SRGAP1(6), SRGAP3(2), UNC5A(2), UNC5D(4)	57082189	305	113	305	110	158	16	82	15	34	0	0.690	1.000	1.000
348	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	128	ACTB(2), ACTG1(5), ACTN1(1), ACTN2(2), ACTN4(2), AKT1(3), AKT2(1), AKT3(3), AMOTL1(2), ASH1L(7), CASK(5), CDC42(1), CGN(5), CLDN10(1), CLDN16(2), CLDN18(2), CLDN2(2), CLDN22(1), CLDN8(1), CTNNA1(2), CTNNA2(4), CTNNA3(6), CTNNB1(5), CTTN(1), EPB41(4), EPB41L1(3), EPB41L2(1), EPB41L3(4), EXOC3(3), EXOC4(3), F11R(2), GNAI1(1), GNAI2(1), GNAI3(3), HCLS1(1), HRAS(1), INADL(4), LLGL1(2), LLGL2(4), MAGI1(3), MAGI2(3), MAGI3(6), MLLT4(5), MPDZ(7), MPP5(6), MRAS(1), MYH1(7), MYH10(9), MYH11(3), MYH13(10), MYH14(3), MYH15(13), MYH2(9), MYH3(8), MYH4(5), MYH6(6), MYH7(8), MYH7B(6), MYH8(7), MYH9(16), MYL5(1), MYL9(1), MYLPF(1), NRAS(1), OCLN(1), PARD3(8), PARD6A(1), PARD6B(2), PPM1J(1), PPP2R1A(2), PPP2R2A(3), PPP2R2B(3), PPP2R2C(3), PPP2R3A(1), PPP2R4(1), PRKCA(3), PRKCD(1), PRKCE(1), PRKCG(1), PRKCH(1), PRKCI(6), PRKCQ(1), PRKCZ(1), RAB13(1), RHOA(2), SPTAN1(11), SYMPK(4), TJP1(7), TJP2(8), TJP3(1), YES1(2), ZAK(5)	56559900	330	112	326	104	199	10	59	23	38	1	0.532	1.000	1.000
349	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(3), CD36(2), CD44(2), COL11A1(11), COL11A2(5), COL1A1(2), COL1A2(3), COL2A1(7), COL3A1(5), COL4A1(4), COL4A2(4), COL4A4(2), COL4A6(4), COL5A1(6), COL5A2(6), COL5A3(3), COL6A1(3), COL6A2(4), COL6A3(10), COL6A6(6), DAG1(3), FN1(5), FNDC1(7), FNDC3A(1), FNDC4(1), GP5(1), GP9(1), HMMR(3), HSPG2(13), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(3), ITGA2B(1), ITGA3(1), ITGA4(6), ITGA5(2), ITGA7(4), ITGA8(5), ITGA9(2), ITGAV(1), ITGB1(2), ITGB3(3), ITGB4(7), ITGB5(1), ITGB6(2), ITGB7(1), ITGB8(2), LAMA1(7), LAMA2(11), LAMA3(4), LAMA4(5), LAMA5(8), LAMB1(2), LAMB2(6), LAMB3(4), LAMB4(1), LAMC1(4), LAMC2(3), LAMC3(4), RELN(7), SDC1(1), SPP1(3), SV2B(1), SV2C(3), THBS1(2), THBS2(2), THBS3(2), THBS4(1), TNC(9), TNN(1), TNXB(7), VWF(6)	65230014	282	110	281	103	139	12	68	22	41	0	0.975	1.000	1.000
350	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	249	ACVR1B(2), ACVR2A(6), AMHR2(1), BMPR1A(1), BMPR1B(2), BMPR2(3), CCL15(1), CCL17(1), CCL23(2), CCR1(3), CCR2(1), CCR3(1), CCR4(2), CCR6(1), CCR7(1), CCR8(2), CCR9(2), CD27(2), CD40(1), CD40LG(3), CD70(2), CLCF1(1), CNTF(2), CRLF2(1), CSF1R(2), CSF2RB(2), CSF3R(3), CX3CL1(3), CX3CR1(2), CXCL16(1), CXCL9(1), CXCR3(1), CXCR4(3), CXCR6(1), EDAR(2), EGF(1), EGFR(7), EPOR(1), FAS(5), FASLG(1), FLT1(7), FLT3(3), FLT4(7), GDF5(5), GH2(1), GHR(6), HGF(5), IFNA10(1), IFNA4(1), IFNA5(1), IFNA6(1), IFNA8(1), IFNAR1(3), IFNAR2(2), IFNG(1), IFNGR1(6), IFNGR2(3), IL11(1), IL11RA(2), IL12A(2), IL12B(2), IL12RB1(1), IL12RB2(2), IL15(2), IL15RA(1), IL17A(1), IL17RB(1), IL18R1(2), IL18RAP(2), IL19(1), IL1A(2), IL1R1(2), IL1R2(2), IL1RAP(5), IL20(1), IL20RA(1), IL21(1), IL21R(1), IL22RA1(1), IL23A(1), IL23R(1), IL26(1), IL3RA(2), IL4R(5), IL5(1), IL5RA(2), IL6(1), IL6R(3), IL6ST(2), IL8(2), IL9R(3), INHBA(1), INHBB(1), INHBC(1), INHBE(1), KDR(2), KIT(3), KITLG(1), LEP(1), LEPR(8), LIFR(2), LTBR(1), MET(2), MPL(1), NGFR(1), OSMR(1), PDGFC(1), PDGFRA(2), PDGFRB(2), PLEKHO2(4), PPBP(1), PRL(3), PRLR(1), TGFB2(1), TGFB3(2), TGFBR1(1), TGFBR2(5), TNFRSF10A(1), TNFRSF10B(1), TNFRSF10C(1), TNFRSF10D(1), TNFRSF11B(1), TNFRSF12A(1), TNFRSF13B(1), TNFRSF14(1), TNFRSF1A(4), TNFRSF1B(2), TNFRSF21(2), TNFRSF6B(1), TNFRSF8(3), TNFSF10(2), TNFSF11(1), TNFSF13B(1), TPO(6), VEGFA(1), VEGFC(4), XCL1(1), XCL2(1), XCR1(4)	51353016	285	105	279	93	145	21	51	20	48	0	0.405	1.000	1.000
351	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	149	AKT1(3), AKT2(1), AKT3(3), CBL(1), CBLB(5), CBLC(3), CCND1(1), CLCF1(1), CNTF(2), CREBBP(15), CRLF2(1), CSF2RB(2), CSF3R(3), EPOR(1), GH2(1), GHR(6), IFNA10(1), IFNA4(1), IFNA5(1), IFNA6(1), IFNA8(1), IFNAR1(3), IFNAR2(2), IFNG(1), IFNGR1(6), IFNGR2(3), IL11(1), IL11RA(2), IL12A(2), IL12B(2), IL12RB1(1), IL12RB2(2), IL13RA2(1), IL15(2), IL15RA(1), IL19(1), IL20(1), IL20RA(1), IL21(1), IL21R(1), IL22RA1(1), IL23A(1), IL23R(1), IL26(1), IL3RA(2), IL4R(5), IL5(1), IL5RA(2), IL6(1), IL6R(3), IL6ST(2), IL9R(3), IRF9(1), JAK1(1), JAK2(6), JAK3(4), LEP(1), LEPR(8), LIFR(2), MPL(1), MYC(1), OSMR(1), PIAS2(1), PIAS3(2), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(10), PIK3R3(4), PIM1(1), PRL(3), PRLR(1), SOCS2(3), SOCS3(6), SOCS4(6), SOCS5(1), SOCS7(1), SOS1(5), SOS2(5), SPRED1(1), SPRED2(1), SPRY1(2), SPRY3(2), SPRY4(2), STAM(2), STAM2(2), STAT1(2), STAT2(3), STAT3(2), STAT4(4), STAT5A(2), STAT5B(1), STAT6(3), TPO(6), TYK2(9)	40216321	234	105	229	73	133	13	39	12	34	3	0.533	1.000	1.000
352	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(4), ADCY2(3), ADCY3(1), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(4), ADCY9(8), ADRA1A(3), ADRA1B(2), ADRA1D(1), ADRB2(2), ARRB1(2), ATP1A4(2), ATP1B1(1), ATP1B3(1), ATP2A2(3), ATP2A3(3), ATP2B1(3), ATP2B2(5), ATP2B3(3), CACNA1A(4), CACNA1B(9), CACNA1C(9), CACNA1D(4), CACNA1E(6), CACNA1S(3), CACNB1(2), CACNB3(2), CALM1(2), CALM3(1), CALR(3), CAMK1(2), CAMK2A(3), CAMK2B(1), CAMK2D(2), CAMK4(2), CASQ1(2), CHRM1(1), CHRM2(3), CHRM3(3), CHRM4(1), CHRM5(1), GJA1(2), GJA5(1), GJB1(1), GJB5(1), GJB6(1), GNA11(2), GNAI2(1), GNAI3(3), GNAO1(1), GNAQ(2), GNB1(1), GNB2(1), GNB3(1), GNB5(4), GNG2(1), GNGT1(1), GRK4(3), GRK5(2), GRK6(1), ITPR1(8), ITPR2(5), ITPR3(2), KCNB1(1), KCNJ5(1), MIB1(2), MYCBP(1), NME7(1), PKIA(1), PKIB(1), PLCB3(2), PRKACA(2), PRKAR2A(1), PRKCA(3), PRKCD(1), PRKCE(1), PRKCG(1), PRKCH(1), PRKCQ(1), PRKCZ(1), PRKD1(4), RGS10(2), RGS11(1), RGS14(3), RGS17(3), RGS18(1), RGS19(1), RGS2(2), RGS20(1), RGS3(8), RGS4(3), RGS5(1), RGS7(2), RGS9(1), RYR1(10), RYR2(26), RYR3(11), SFN(1), SLC8A1(1), YWHAQ(2)	56070717	282	99	282	114	155	10	72	20	25	0	0.719	1.000	1.000
353	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(1), ACTN2(2), ACTN4(2), DMD(23), MYBPC1(3), MYBPC2(6), MYBPC3(1), MYH3(8), MYH6(6), MYH7(8), MYH8(7), MYL1(2), MYL3(2), MYL9(1), MYOM1(2), NEB(24), TMOD1(1), TNNT2(2), TPM2(3), TPM4(1), TTN(136), VIM(1)	41041892	242	97	242	78	144	14	46	15	21	2	0.888	1.000	1.000
354	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	141	ADA(2), ADCY1(4), ADCY2(3), ADCY3(1), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(4), ADCY9(8), ADSS(1), ADSSL1(2), AK2(1), AK5(1), AK7(5), ALLC(2), AMPD1(2), AMPD2(2), APRT(1), CANT1(1), DCK(1), DGUOK(2), ENPP1(2), ENPP3(5), ENTPD3(2), ENTPD4(1), GART(1), GDA(3), GMPR(1), GMPS(2), GUCY1A2(4), GUCY1A3(3), GUCY1B3(2), GUCY2C(1), GUCY2D(3), GUCY2F(5), GUK1(1), HPRT1(1), IMPDH1(2), IMPDH2(1), NME6(1), NME7(1), NPR1(2), NT5C(2), NT5C1A(2), NT5C1B(2), NT5C2(3), NT5E(1), NUDT9(1), PAICS(1), PAPSS1(1), PAPSS2(2), PDE10A(2), PDE11A(2), PDE1A(3), PDE1C(6), PDE2A(2), PDE4A(3), PDE4B(5), PDE5A(4), PDE6D(2), PDE7B(1), PDE8A(1), PDE8B(1), PDE9A(1), PFAS(2), PKLR(3), PNPT1(1), POLA1(5), POLA2(1), POLD1(3), POLD2(1), POLD3(1), POLE(7), POLR1A(7), POLR1B(3), POLR1C(3), POLR2A(5), POLR2B(3), POLR2C(1), POLR2F(1), POLR2H(1), POLR2L(1), POLR3A(1), POLR3B(3), POLR3G(2), PPAT(1), PRIM1(1), PRPS2(2), PRUNE(1), RFC5(2), RRM1(2), RRM2B(1), XDH(2)	47921728	216	94	216	90	121	10	51	16	18	0	0.966	1.000	1.000
355	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	141	APC(7), AXIN2(2), BTRC(1), CAMK2A(3), CAMK2B(1), CAMK2D(2), CCND1(1), CHD8(10), CREBBP(15), CTBP1(1), CTBP2(3), CTNNB1(5), CTNNBIP1(3), CUL1(4), DAAM1(3), DAAM2(4), DKK1(1), FBXW11(1), FZD1(1), FZD10(2), FZD2(2), FZD3(1), FZD4(3), FZD5(2), FZD6(2), FZD7(1), FZD8(1), JUN(2), LEF1(1), LRP5(8), LRP6(7), MAPK8(1), MAPK9(4), MMP7(1), MYC(1), NFAT5(5), NFATC1(4), NFATC2(4), NFATC3(5), NFATC4(3), NKD1(1), NKD2(1), PLCB1(10), PLCB2(2), PLCB3(2), PLCB4(1), PORCN(3), PPARD(2), PPP2R1A(2), PPP2R2A(3), PPP2R2B(3), PPP2R2C(3), PPP3CA(1), PPP3CC(1), PRICKLE2(1), PRKACA(2), PRKCA(3), PRKCG(1), PSEN1(4), RAC1(1), RAC2(1), RAC3(1), RBX1(1), RHOA(2), ROCK1(3), ROCK2(4), RUVBL1(2), SENP2(1), SFRP2(1), SFRP4(1), SMAD2(1), SMAD3(2), SMAD4(7), SOX17(2), TBL1X(1), TBL1XR1(5), TCF7L1(2), TCF7L2(2), TP53(12), VANGL2(1), WIF1(1), WNT1(1), WNT10A(1), WNT11(1), WNT16(1), WNT2B(1), WNT5B(2), WNT7B(4), WNT8A(1), WNT8B(3)	44405804	243	94	238	86	134	7	56	17	28	1	0.872	1.000	1.000
356	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	126	ALCAM(2), CADM1(2), CADM3(1), CD22(3), CD226(3), CD274(1), CD34(2), CD4(1), CD40(1), CD40LG(3), CD58(2), CD6(2), CD8A(2), CD8B(1), CD99(1), CDH1(2), CDH15(2), CDH2(1), CDH4(2), CDH5(1), CLDN10(1), CLDN16(2), CLDN18(2), CLDN2(2), CLDN22(1), CLDN8(1), CNTN1(4), CNTN2(1), CNTNAP1(5), CNTNAP2(8), F11R(2), GLG1(5), HLA-C(5), HLA-DMA(2), HLA-DMB(2), HLA-DPB1(3), HLA-DQA1(3), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(1), HLA-E(2), HLA-F(2), HLA-G(2), ICAM2(1), ICAM3(4), ICOSLG(2), ITGA4(6), ITGA8(5), ITGA9(2), ITGAL(4), ITGAM(4), ITGAV(1), ITGB1(2), ITGB7(1), ITGB8(2), L1CAM(5), MADCAM1(3), MAG(1), MPZ(1), MPZL1(1), NCAM1(4), NCAM2(5), NEGR1(1), NEO1(4), NFASC(4), NLGN1(4), NLGN3(4), NRCAM(5), NRXN1(4), NRXN2(2), NRXN3(4), OCLN(1), PDCD1LG2(1), PTPRC(10), PTPRF(7), PTPRM(6), PVR(1), PVRL1(3), PVRL2(1), PVRL3(5), SDC1(1), SELE(1), SELL(1), SIGLEC1(5), SPN(1), VCAM1(2), VCAN(15)	41324578	242	93	239	84	122	13	46	20	40	1	0.703	1.000	1.000
357	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	126	ACACA(5), ACACB(6), AKT1(3), AKT2(1), AKT3(3), ARAF(1), BAD(2), BRAF(2), CALM1(2), CALM3(1), CALML6(1), CBL(1), CBLB(5), CBLC(3), CRK(1), ELK1(2), EXOC7(2), FASN(4), FLOT2(2), FOXO1(1), G6PC(3), G6PC2(1), GCK(2), GYS1(2), GYS2(2), HRAS(1), IKBKB(2), INPP5D(4), INSR(4), IRS1(2), IRS4(2), LIPE(2), MAP2K1(2), MAPK3(1), MAPK8(1), MAPK9(4), MKNK1(1), MKNK2(2), NRAS(1), PCK2(1), PDE3A(5), PDPK1(2), PHKA1(4), PHKA2(7), PHKB(3), PHKG2(1), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(10), PIK3R3(4), PKLR(3), PPARGC1A(1), PPP1CB(2), PPP1CC(1), PPP1R3A(6), PRKAA2(3), PRKACA(2), PRKAG1(1), PRKAG2(2), PRKAR2A(1), PRKCI(6), PRKCZ(1), PTPN1(1), PTPRF(7), PYGB(3), PYGM(1), RAPGEF1(4), RPS6KB1(1), RPS6KB2(1), SHC2(3), SHC3(1), SOCS2(3), SOCS3(6), SOCS4(6), SORBS1(5), SOS1(5), SOS2(5), SREBF1(3), TRIP10(3), TSC1(2), TSC2(6)	45679622	223	92	222	75	131	9	49	10	24	0	0.589	1.000	1.000
358	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	136	ACTA1(1), ADCY1(4), ADCY2(3), ADCY3(1), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(4), ADCY9(8), ARRB1(2), ATF2(2), ATF4(2), ATF5(1), ATP2A2(3), ATP2A3(3), CACNB3(2), CALM1(2), CALM3(1), CAMK2A(3), CAMK2B(1), CAMK2D(2), CNN2(1), CORIN(3), CREB3(1), CRHR1(2), DGKZ(5), ETS2(1), FOS(2), GABPB2(1), GBA2(1), GJA1(2), GNAQ(2), GNB1(1), GNB2(1), GNB3(1), GNB5(4), GNG2(1), GNGT1(1), GRK4(3), GRK5(2), GRK6(1), GSTO1(1), GUCY1A3(3), IL6(1), ITPR1(8), ITPR2(5), ITPR3(2), JUN(2), MIB1(2), NFKB1(2), NOS1(2), NOS3(6), OXTR(3), PDE4B(5), PKIA(1), PKIB(1), PLCB3(2), PLCD1(2), PLCG1(3), PLCG2(4), PRKACA(2), PRKAR2A(1), PRKCA(3), PRKCD(1), PRKCE(1), PRKCH(1), PRKCQ(1), PRKCZ(1), PRKD1(4), RAMP2(3), RGS10(2), RGS11(1), RGS14(3), RGS17(3), RGS18(1), RGS19(1), RGS2(2), RGS20(1), RGS3(8), RGS4(3), RGS5(1), RGS7(2), RGS9(1), RLN1(1), RYR1(10), RYR2(26), RYR3(11), SFN(1), SLC8A1(1), SP1(3), TNXB(7), YWHAQ(2)	50377111	259	92	258	96	149	6	55	22	27	0	0.653	1.000	1.000
359	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	105	ABL1(8), ANAPC1(2), ANAPC2(4), ANAPC5(1), ANAPC7(1), ATM(11), ATR(6), BUB1(4), BUB1B(1), CCNA1(2), CCNA2(2), CCNB3(4), CCND1(1), CDC14A(3), CDC14B(3), CDC16(1), CDC20(2), CDC25A(2), CDC25B(4), CDC25C(2), CDC27(3), CDC6(1), CDC7(2), CDK2(1), CDKN1A(1), CHEK1(1), CHEK2(1), CREBBP(15), CUL1(4), DBF4(1), E2F2(1), E2F3(3), ESPL1(5), FZR1(2), GADD45B(1), MCM2(1), MCM5(2), MCM6(1), MCM7(3), MDM2(1), PCNA(1), PKMYT1(1), PLK1(1), PRKDC(11), PTTG2(1), RBL1(3), RBL2(2), RBX1(1), SFN(1), SMAD2(1), SMAD3(2), SMAD4(7), SMC1A(4), SMC1B(2), TFDP1(2), TGFB2(1), TGFB3(2), TP53(12), YWHAE(2), YWHAQ(2), YWHAZ(3)	37905931	176	88	172	52	107	4	25	11	28	1	0.667	1.000	1.000
360	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	73	ACP1(2), ACTB(2), ACTG1(5), ACTN1(1), ACTN2(2), ACTN4(2), ACVR1B(2), ACVR1C(1), CDC42(1), CDH1(2), CREBBP(15), CTNNA1(2), CTNNA2(4), CTNNA3(6), CTNNB1(5), CTNND1(4), EGFR(7), ERBB2(11), FARP2(3), FER(3), FGFR1(1), FYN(3), IGF1R(3), INSR(4), IQGAP1(10), LEF1(1), LMO7(8), MAPK3(1), MET(2), MLLT4(5), PARD3(8), PTPN1(1), PTPRB(5), PTPRF(7), PTPRJ(1), PTPRM(6), PVRL1(3), PVRL2(1), PVRL3(5), RAC1(1), RAC2(1), RAC3(1), RHOA(2), SMAD2(1), SMAD3(2), SMAD4(7), SNAI1(2), SORBS1(5), SSX2IP(1), TCF7L1(2), TCF7L2(2), TGFBR1(1), TGFBR2(5), TJP1(7), VCL(3), WASF1(3), WASF2(2), WASF3(1), WASL(4), YES1(2)	33488822	210	87	205	62	118	7	36	10	38	1	0.466	1.000	1.000
361	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	159	ADORA1(1), ADORA3(3), ADRA1A(3), ADRA1B(2), ADRA1D(1), ADRA2C(1), ADRB2(2), AGTR1(1), AVPR1A(1), AVPR1B(2), AVPR2(2), BRS3(3), CCKAR(1), CCKBR(1), CCR1(3), CCR2(1), CCR3(1), CCR4(2), CCR6(1), CCR7(1), CCR8(2), CCR9(2), CCRL2(1), CHRM1(1), CHRM2(3), CHRM3(3), CHRM4(1), CHRM5(1), CMKLR1(4), CNR1(1), CNR2(1), CX3CR1(2), CXCR3(1), CXCR4(3), DRD3(2), EDNRA(1), EDNRB(2), F2R(1), F2RL2(1), F2RL3(2), FPR1(1), FSHR(2), GALR2(1), GALT(2), GHSR(2), GPR173(3), GPR174(2), GPR3(1), GPR35(1), GPR37(1), GPR50(2), GPR63(2), GPR83(1), GPR85(1), GRPR(4), HCRTR1(1), HCRTR2(2), HRH1(2), HRH2(1), HTR1A(4), HTR1B(2), HTR1D(1), HTR1F(2), HTR2B(2), HTR2C(2), HTR4(1), HTR5A(1), HTR6(3), HTR7(2), LHCGR(1), MAS1(2), MC1R(1), MC3R(1), MC5R(2), MLNR(3), MTNR1A(1), MTNR1B(2), NPY1R(2), NPY2R(2), NPY5R(4), NTSR1(1), OPN1SW(1), OPRL1(1), OPRM1(3), OR10A5(2), OR1C1(2), OR1Q1(2), OR7C1(1), OR8B8(2), OXTR(3), P2RY1(1), P2RY10(1), P2RY12(1), P2RY13(3), P2RY14(1), PTAFR(1), PTGDR(2), PTGER4(2), PTGFR(1), RGR(1), RRH(2), TBXA2R(1)	33804248	176	86	176	87	85	14	54	12	11	0	0.514	1.000	1.000
362	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	90	ADCY1(4), ADCY2(3), ADCY3(1), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(4), ADCY9(8), CSNK1D(2), EGF(1), EGFR(7), GJA1(2), GJD2(2), GNA11(2), GNAI1(1), GNAI2(1), GNAI3(3), GNAQ(2), GNAS(6), GRM1(3), GRM5(5), GUCY1A2(4), GUCY1A3(3), GUCY1B3(2), GUCY2C(1), GUCY2D(3), GUCY2F(5), HRAS(1), HTR2B(2), HTR2C(2), ITPR1(8), ITPR2(5), ITPR3(2), MAP2K1(2), MAP3K2(1), MAPK3(1), MAPK7(2), NPR1(2), NRAS(1), PDGFC(1), PDGFRA(2), PDGFRB(2), PLCB1(10), PLCB2(2), PLCB3(2), PLCB4(1), PRKACA(2), PRKCA(3), PRKCG(1), PRKG2(3), SOS1(5), SOS2(5), TJP1(7), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3C(2), TUBA3D(1), TUBA8(2), TUBB(1), TUBB8(1)	38135954	175	86	175	85	101	8	46	10	10	0	0.988	1.000	1.000
363	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(3), AKT3(3), CAPN1(5), CAPN3(5), CAPN6(2), CAPN9(3), CAPNS1(1), CAV2(1), CDC42(1), CRK(1), DOCK1(4), FYN(3), GIT2(2), ITGA10(2), ITGA11(3), ITGA2(3), ITGA2B(1), ITGA3(1), ITGA4(6), ITGA5(2), ITGA7(4), ITGA8(5), ITGA9(2), ITGAD(1), ITGAE(3), ITGAL(4), ITGAM(4), ITGAV(1), ITGAX(3), ITGB1(2), ITGB3(3), ITGB4(7), ITGB5(1), ITGB6(2), ITGB7(1), ITGB8(2), MAP2K1(2), MAP2K3(2), MAPK4(1), MAPK6(2), MAPK7(2), PAK1(1), PAK2(1), PAK3(1), PAK4(2), PAK6(3), PDPK1(2), PTK2(2), PXN(2), RAC1(1), RAC2(1), RAC3(1), RAP1B(1), RAPGEF1(4), ROCK1(3), ROCK2(4), SDCCAG8(4), SHC3(1), SORBS1(5), SOS1(5), TLN1(3), TNS1(5), VASP(1), VAV2(3), VAV3(3), VCL(3), ZYX(1)	39668168	169	86	168	73	92	11	36	6	24	0	0.975	1.000	1.000
364	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	96	ADCY1(4), ADCY2(3), ADCY3(1), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(4), ADCY9(8), CALM1(2), CALM3(1), CALML6(1), CAMK2A(3), CAMK2B(1), CAMK2D(2), CREB1(2), CREB3(1), CREB3L1(1), CREB3L2(1), CREB3L3(3), CREB3L4(2), CREBBP(15), CTNNB1(5), DCT(2), EDN1(1), EDNRB(2), FZD1(1), FZD10(2), FZD2(2), FZD3(1), FZD4(3), FZD5(2), FZD6(2), FZD7(1), FZD8(1), GNAI1(1), GNAI2(1), GNAI3(3), GNAO1(1), GNAQ(2), GNAS(6), HRAS(1), KIT(3), KITLG(1), LEF1(1), MAP2K1(2), MAPK3(1), MC1R(1), NRAS(1), PLCB1(10), PLCB2(2), PLCB3(2), PLCB4(1), POMC(2), PRKACA(2), PRKCA(3), PRKCG(1), TCF7L1(2), TCF7L2(2), TYR(2), WNT1(1), WNT10A(1), WNT11(1), WNT16(1), WNT2B(1), WNT5B(2), WNT7B(4), WNT8A(1), WNT8B(3)	29377261	163	85	161	56	93	3	44	10	12	1	0.339	1.000	1.000
365	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(1), AMY2A(3), AMY2B(3), ASCC3(4), ATP13A2(5), DDX18(1), DDX19A(2), DDX23(3), DDX41(6), DDX50(1), DDX52(2), DHX58(1), ENPP1(2), ENPP3(5), ENTPD7(1), EP400(9), ERCC2(1), ERCC3(1), G6PC(3), G6PC2(1), GAA(4), GANC(1), GCK(2), GPI(3), GUSB(4), GYS1(2), GYS2(2), HK1(2), HK2(4), HK3(1), IFIH1(2), LYZL1(2), MGAM(12), MOV10L1(4), NUDT8(1), PGM3(1), PYGB(3), PYGM(1), RAD54B(2), RAD54L(3), SETX(3), SI(12), SKIV2L2(5), SMARCA2(4), SMARCA5(3), UGP2(2), UGT1A1(2), UGT1A4(1), UGT1A5(1), UGT1A6(1), UGT2A1(2), UGT2A3(3), UGT2B10(3), UGT2B11(3), UGT2B15(5), UGT2B17(3), UGT2B4(1), UGT2B7(1), UXS1(2)	36539286	168	83	167	47	91	6	34	17	20	0	0.294	1.000	1.000
366	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	93	ADCY1(4), ADCY2(3), ADCY3(1), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(4), ADCY9(8), ATF4(2), CACNA1C(9), CACNA1D(4), CACNA1F(6), CACNA1S(3), CALM1(2), CALM3(1), CALML6(1), CAMK2A(3), CAMK2B(1), CAMK2D(2), CDC42(1), CGA(1), EGFR(7), ELK1(2), GNA11(2), GNAQ(2), GNAS(6), GNRH2(1), HRAS(1), ITPR1(8), ITPR2(5), ITPR3(2), JUN(2), MAP2K1(2), MAP2K3(2), MAP2K7(1), MAP3K1(4), MAP3K2(1), MAP3K3(1), MAP3K4(6), MAPK11(2), MAPK13(1), MAPK3(1), MAPK7(2), MAPK8(1), MAPK9(4), MMP2(6), NRAS(1), PLA2G12A(1), PLA2G12B(3), PLA2G2D(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLCB1(10), PLCB2(2), PLCB3(2), PLCB4(1), PLD1(3), PRKACA(2), PRKCA(3), PRKCD(1), PTK2B(3), SOS1(5), SOS2(5)	37559678	191	83	191	79	112	8	46	15	10	0	0.855	1.000	1.000
367	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(5), ABCA10(4), ABCA12(16), ABCA13(15), ABCA2(6), ABCA3(3), ABCA4(6), ABCA5(6), ABCA6(5), ABCA7(5), ABCA8(4), ABCA9(4), ABCB1(4), ABCB10(1), ABCB11(4), ABCB4(5), ABCB5(4), ABCB6(1), ABCB7(3), ABCB9(1), ABCC1(1), ABCC10(4), ABCC11(3), ABCC12(1), ABCC2(3), ABCC3(9), ABCC4(5), ABCC5(4), ABCC6(2), ABCC8(4), ABCC9(1), ABCD1(7), ABCD2(1), ABCD3(3), ABCD4(4), ABCG1(3), ABCG2(2), ABCG4(1), ABCG8(2), CFTR(4), TAP1(3), TAP2(2)	34478732	171	82	169	67	71	11	41	20	27	1	0.748	1.000	1.000
368	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	91	ADCY1(4), ADCY2(3), ADCY3(1), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(4), ADCY9(8), AKAP1(1), AKAP10(2), AKAP11(5), AKAP12(5), AKAP2(1), AKAP3(6), AKAP4(4), AKAP5(1), AKAP6(6), AKAP7(3), AKAP8(3), AKAP9(3), ARHGEF1(1), CALM1(2), CALM3(1), GNA11(2), GNA12(2), GNA13(3), GNA15(4), GNAI2(1), GNAI3(3), GNAL(2), GNAO1(1), GNAQ(2), GNB1(1), GNB2(1), GNB3(1), GNB5(4), GNGT1(1), HRAS(1), ITPR1(8), NRAS(1), PDE1A(3), PDE1B(2), PDE1C(6), PDE4A(3), PDE4B(5), PDE7B(1), PDE8A(1), PDE8B(1), PLCB3(2), PPP3CA(1), PPP3CC(1), PRKACA(2), PRKAR2A(1), PRKCA(3), PRKCD(1), PRKCE(1), PRKCG(1), PRKCH(1), PRKCI(6), PRKCQ(1), PRKCZ(1), PRKD1(4), PRKD3(1), RHOA(2), SLC9A1(4)	34053879	171	81	171	49	104	5	33	16	13	0	0.255	1.000	1.000
369	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	108	ACTN1(1), ACTN2(2), ACTN4(2), ARHGAP5(4), CD99(1), CDC42(1), CDH5(1), CLDN10(1), CLDN16(2), CLDN18(2), CLDN2(2), CLDN22(1), CLDN8(1), CTNNA1(2), CTNNA2(4), CTNNA3(6), CTNNB1(5), CTNND1(4), CXCR4(3), CYBB(2), EZR(6), F11R(2), GNAI1(1), GNAI2(1), GNAI3(3), ITGA4(6), ITGAL(4), ITGAM(4), ITGB1(2), ITK(1), MAPK11(2), MAPK13(1), MLLT4(5), MMP2(6), MMP9(1), MSN(2), MYL5(1), MYL9(1), MYLPF(1), NCF2(2), NCF4(2), NOX1(2), NOX3(4), OCLN(1), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(10), PIK3R3(4), PLCG1(3), PLCG2(4), PRKCA(3), PRKCG(1), PTK2(2), PTK2B(3), PXN(2), RAC1(1), RAC2(1), RAP1A(1), RAP1B(1), RAPGEF3(1), RAPGEF4(4), RHOA(2), RHOH(1), ROCK1(3), ROCK2(4), SIPA1(2), THY1(1), TXK(2), VASP(1), VAV1(2), VAV2(3), VAV3(3), VCAM1(2), VCL(3)	35711151	182	81	181	61	98	8	46	13	17	0	0.547	1.000	1.000
370	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(2), ADCY1(4), ADCY2(3), ADCY3(1), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(4), ADSS(1), AK2(1), AK5(1), ALLC(2), AMPD1(2), AMPD2(2), APRT(1), ATP1B1(1), ATP5D(1), ATP5F1(3), ATP5G3(1), ATP5H(1), ATP5J(2), CANT1(1), DCK(1), DGUOK(2), ENPP1(2), ENPP3(5), GART(1), GDA(3), GMPS(2), GUCY1A2(4), GUCY1A3(3), GUCY1B3(2), GUCY2C(1), GUCY2D(3), GUCY2F(5), GUK1(1), HPRT1(1), IMPDH1(2), IMPDH2(1), NPR1(2), NT5C(2), NT5E(1), PAICS(1), PAPSS1(1), PAPSS2(2), PDE1A(3), PDE4A(3), PDE4B(5), PDE5A(4), PDE6B(1), PDE6C(2), PDE7B(1), PDE8A(1), PDE9A(1), PFAS(2), PKLR(3), POLB(1), POLD1(3), POLD2(1), POLE(7), POLG(3), POLL(1), POLQ(13), POLR1B(3), POLR2A(5), POLR2B(3), POLR2C(1), POLR2F(1), POLR2H(1), POLR2L(1), POLRMT(5), PPAT(1), PRPS2(2), PRUNE(1), RRM1(2)	37262055	177	76	177	78	102	8	38	12	17	0	0.977	1.000	1.000
371	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	82	ABL1(8), ABL2(1), AKT1(3), AKT2(1), AKT3(3), ARAF(1), BAD(2), BRAF(2), BTC(1), CAMK2A(3), CAMK2B(1), CAMK2D(2), CBL(1), CBLB(5), CBLC(3), CDKN1A(1), CRK(1), EGF(1), EGFR(7), ELK1(2), ERBB2(11), ERBB3(12), ERBB4(4), GAB1(2), HRAS(1), JUN(2), MAP2K1(2), MAP2K7(1), MAPK3(1), MAPK8(1), MAPK9(4), MYC(1), NCK1(2), NRAS(1), NRG1(1), NRG2(1), NRG3(3), NRG4(1), PAK1(1), PAK2(1), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(10), PIK3R3(4), PLCG1(3), PLCG2(4), PRKCA(3), PRKCG(1), PTK2(2), RPS6KB1(1), RPS6KB2(1), SHC2(3), SHC3(1), SOS1(5), SOS2(5), STAT5A(2), STAT5B(1)	28810428	160	75	153	49	84	4	48	11	13	0	0.436	1.000	1.000
372	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	84	ACVR1B(2), ACVR1C(1), ACVR2A(6), ACVRL1(1), AMHR2(1), BMP4(2), BMP5(1), BMP6(1), BMP8A(1), BMPR1A(1), BMPR1B(2), BMPR2(3), CHRD(3), COMP(3), CREBBP(15), CUL1(4), E2F4(1), E2F5(1), GDF5(5), GDF6(2), GDF7(1), ID1(1), ID4(1), IFNG(1), INHBA(1), INHBB(1), INHBC(1), INHBE(1), LEFTY1(1), LEFTY2(2), LTBP1(2), MAPK3(1), MYC(1), NODAL(2), PITX2(2), PPP2R1A(2), PPP2R2A(3), PPP2R2B(3), PPP2R2C(3), RBL1(3), RBL2(2), RBX1(1), RHOA(2), ROCK1(3), ROCK2(4), RPS6KB1(1), RPS6KB2(1), SMAD1(1), SMAD2(1), SMAD3(2), SMAD4(7), SMAD5(3), SMAD7(1), SMURF2(2), SP1(3), TFDP1(2), TGFB2(1), TGFB3(2), TGFBR1(1), TGFBR2(5), THBS1(2), THBS2(2), THBS3(2), THBS4(1), ZFYVE16(4), ZFYVE9(4)	26645142	149	75	147	46	73	10	29	13	23	1	0.704	1.000	1.000
373	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	121	ARAF(1), BID(1), BRAF(2), CASP3(1), CD244(2), CD247(1), FAS(5), FASLG(1), FCER1G(1), FYN(3), GZMB(1), HLA-C(5), HLA-E(2), HLA-G(2), HRAS(1), ICAM2(1), IFNA10(1), IFNA4(1), IFNA5(1), IFNA6(1), IFNA8(1), IFNAR1(3), IFNAR2(2), IFNG(1), IFNGR1(6), IFNGR2(3), ITGAL(4), KIR2DL1(1), KIR2DL3(1), KIR3DL1(1), KIR3DL2(1), KLRD1(2), LAT(1), LCP2(1), MAP2K1(2), MAPK3(1), MICA(2), NCR1(1), NCR2(3), NCR3(1), NFAT5(5), NFATC1(4), NFATC2(4), NFATC3(5), NFATC4(3), NRAS(1), PAK1(1), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(10), PIK3R3(4), PLCG1(3), PLCG2(4), PPP3CA(1), PPP3CC(1), PRF1(1), PRKCA(3), PRKCG(1), PTK2B(3), RAC1(1), RAC2(1), RAC3(1), SH3BP2(1), SHC2(3), SHC3(1), SOS1(5), SOS2(5), SYK(1), TNFRSF10A(1), TNFRSF10B(1), TNFRSF10C(1), TNFRSF10D(1), TNFSF10(2), TYROBP(1), ULBP1(1), ULBP2(1), ULBP3(1), VAV1(2), VAV2(3), VAV3(3), ZAP70(2)	31326174	169	73	167	59	95	9	35	7	22	1	0.678	1.000	1.000
374	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	83	ATF2(2), BRAF(2), CEBPA(2), CHUK(2), CREB1(2), DAXX(2), ELK1(2), FOS(2), HRAS(1), IKBKB(2), JUN(2), MAP2K1(2), MAP2K3(2), MAP2K7(1), MAP3K1(4), MAP3K10(2), MAP3K12(3), MAP3K13(1), MAP3K2(1), MAP3K3(1), MAP3K4(6), MAP3K5(11), MAP3K6(4), MAP3K8(1), MAP3K9(5), MAP4K1(3), MAP4K2(2), MAP4K3(1), MAP4K4(3), MAP4K5(4), MAPK11(2), MAPK13(1), MAPK3(1), MAPK4(1), MAPK6(2), MAPK7(2), MAPK8(1), MAPK9(4), MAPKAPK2(2), MAPKAPK3(1), MAPKAPK5(1), MAX(2), MEF2A(1), MEF2B(1), MEF2C(1), MEF2D(3), MKNK1(1), MKNK2(2), MYC(1), NFKB1(2), NFKBIA(2), PAK1(1), PAK2(1), RAC1(1), RELA(7), RIPK1(2), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA4(1), RPS6KA5(2), RPS6KB1(1), RPS6KB2(1), SP1(3), STAT1(2), TGFB2(1), TGFB3(2), TGFBR1(1), TRAF2(1)	28091787	144	72	144	43	80	6	32	11	15	0	0.528	1.000	1.000
375	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	71	CALM1(2), CALM3(1), CALML6(1), DGKA(3), DGKB(1), DGKE(1), DGKG(3), DGKH(2), DGKI(4), DGKQ(1), DGKZ(5), IMPA2(2), INPP1(2), INPP4A(3), INPP4B(4), INPP5B(2), INPP5D(4), INPP5E(1), INPPL1(4), ITPK1(1), ITPKA(1), ITPKB(1), ITPR1(8), ITPR2(5), ITPR3(2), OCRL(3), PI4KA(5), PI4KB(1), PIK3C2A(4), PIK3C2B(4), PIK3C2G(5), PIK3C3(4), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(10), PIK3R3(4), PIP4K2A(1), PIP5K1A(1), PIP5K1B(1), PIP5K1C(3), PLCB1(10), PLCB2(2), PLCB3(2), PLCB4(1), PLCD1(2), PLCD3(3), PLCD4(2), PLCE1(9), PLCG1(3), PLCG2(4), PLCZ1(3), PRKCA(3), PRKCG(1), SYNJ1(2), SYNJ2(1)	36031166	162	71	162	55	94	6	31	13	18	0	0.598	1.000	1.000
376	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	72	ARAF(1), BRAF(2), CACNA1A(4), CRHR1(2), GNA11(2), GNA12(2), GNA13(3), GNAI1(1), GNAI2(1), GNAI3(3), GNAO1(1), GNAQ(2), GNAS(6), GRIA1(4), GRIA2(2), GRIA3(6), GRID2(2), GRM1(3), GRM5(5), GUCY1A2(4), GUCY1A3(3), GUCY1B3(2), GUCY2C(1), GUCY2D(3), GUCY2F(5), HRAS(1), IGF1R(3), ITPR1(8), ITPR2(5), ITPR3(2), MAP2K1(2), MAPK3(1), NOS1(2), NOS3(6), NPR1(2), NRAS(1), PLA2G12A(1), PLA2G12B(3), PLA2G2D(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLCB1(10), PLCB2(2), PLCB3(2), PLCB4(1), PPP2R1A(2), PPP2R2A(3), PPP2R2B(3), PPP2R2C(3), PRKCA(3), PRKCG(1), PRKG2(3), RYR1(10)	32151943	157	71	157	69	83	7	38	14	15	0	0.942	1.000	1.000
377	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	57	ASH1L(7), CARM1(1), CTCFL(2), DOT1L(6), EHMT1(5), EHMT2(3), EZH1(5), EZH2(3), FBXO11(6), HCFC1(5), HSF4(3), JMJD4(1), JMJD6(3), KDM6A(11), NSD1(19), OGT(4), PAXIP1(1), PPP1CB(2), PPP1CC(1), PRDM2(5), PRDM7(1), PRDM9(7), PRMT1(1), PRMT5(1), PRMT6(1), PRMT7(3), SATB1(1), SETD1B(1), SETD2(5), SETD8(2), SETDB1(6), SETDB2(1), SETMAR(5), STK38(2), SUV39H1(1), SUV39H2(2), SUV420H1(2), WHSC1(5), WHSC1L1(3)	35945164	143	70	142	48	81	4	25	12	20	1	0.950	1.000	1.000
378	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	79	ABL1(8), ATM(11), BUB1(4), BUB1B(1), CCNA1(2), CCNA2(2), CCNB3(4), CDC14A(3), CDC14B(3), CDC20(2), CDC25A(2), CDC25B(4), CDC25C(2), CDC6(1), CDC7(2), CDH1(2), CDK2(1), CDKN1A(1), CHEK1(1), CHEK2(1), DTX4(1), E2F2(1), E2F3(3), E2F4(1), E2F5(1), E2F6(1), ESPL1(5), HDAC3(3), HDAC4(3), HDAC5(2), HDAC6(4), HDAC8(1), MCM2(1), MCM5(2), MCM6(1), MCM7(3), MDM2(1), MPEG1(2), MPL(1), PCNA(1), PLK1(1), PRKDC(11), PTPRA(2), PTTG2(1), RBL1(3), SMAD4(7), TBC1D8(1), TFDP1(2), TP53(12)	30508895	135	70	132	35	77	7	24	11	16	0	0.249	1.000	1.000
379	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	64	ADCY1(4), ADCY8(4), ARAF(1), ATF4(2), BRAF(2), CACNA1C(9), CALM1(2), CALM3(1), CALML6(1), CAMK2A(3), CAMK2B(1), CAMK2D(2), CAMK4(2), CREBBP(15), GNAQ(2), GRIA1(4), GRIA2(2), GRIN2A(4), GRIN2B(3), GRIN2D(3), GRM1(3), GRM5(5), HRAS(1), ITPR1(8), ITPR2(5), ITPR3(2), MAP2K1(2), MAPK3(1), NRAS(1), PLCB1(10), PLCB2(2), PLCB3(2), PLCB4(1), PPP1CB(2), PPP1CC(1), PPP1R12A(7), PPP1R1A(1), PPP3CA(1), PPP3CC(1), PRKACA(2), PRKCA(3), PRKCG(1), RAP1A(1), RAP1B(1), RAPGEF3(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA6(6)	28043656	143	69	142	65	81	6	32	11	12	1	0.968	1.000	1.000
380	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	68	ACACB(6), ACSL1(1), ACSL3(2), ACSL4(5), ACSL5(2), ACSL6(1), ADIPOR2(2), AKT1(3), AKT2(1), AKT3(3), CAMKK1(1), CAMKK2(4), CD36(2), CHUK(2), CPT1A(4), CPT1B(3), CPT1C(1), CPT2(1), G6PC(3), G6PC2(1), IKBKB(2), IRS1(2), IRS4(2), JAK1(1), JAK2(6), JAK3(4), LEP(1), LEPR(8), MAPK8(1), MAPK9(4), NFKB1(2), NFKB2(1), NFKBIA(2), NFKBIE(2), PCK2(1), POMC(2), PPARA(1), PPARGC1A(1), PRKAA2(3), PRKAG1(1), PRKAG2(2), PRKCQ(1), RELA(7), RXRA(1), SLC2A1(1), SOCS3(6), STAT3(2), STK11(8), TNFRSF1A(4), TNFRSF1B(2), TRAF2(1), TYK2(9)	23523251	139	69	138	33	77	9	27	8	16	2	0.0396	1.000	1.000
381	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	74	ABL1(8), ACTN1(1), ACTR2(1), AKT1(3), AKT2(1), AKT3(3), ARHGEF6(1), ARHGEF7(4), BRAF(2), CDC42(1), CRK(1), CSE1L(3), DOCK1(4), EPHB2(3), FYN(3), GRB7(3), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(3), ITGA3(1), ITGA4(6), ITGA5(2), ITGA7(4), ITGA8(5), ITGA9(2), MAP2K7(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(2), MAPK9(4), MRAS(1), MYLK(2), P4HB(2), PAK1(1), PAK2(1), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PIK3CB(2), PKLR(3), PLCG1(3), PLCG2(4), PTK2(2), RALA(1), ROCK1(3), ROCK2(4), SOS1(5), SOS2(5), TLN1(3), TLN2(1), VASP(1), ZYX(1)	34470073	136	69	135	66	78	6	30	5	17	0	0.998	1.000	1.000
382	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CD2BP2(1), CDC40(1), CLK2(3), CLK3(2), CLK4(2), COL2A1(7), CPSF1(10), CPSF2(2), CPSF3(1), CPSF4(3), CSTF1(1), CSTF2(3), CSTF2T(2), CSTF3(4), DDIT3(1), DDX1(1), DDX20(3), DHX15(1), DHX16(1), DHX38(4), DHX8(4), DHX9(5), DICER1(3), DNAJC8(2), FUS(1), GIPC1(1), METTL3(1), NCBP1(2), NONO(2), NXF1(5), PABPN1(1), PAPOLA(1), POLR2A(5), PPM1G(2), PRPF18(2), PRPF3(2), PRPF4(3), PRPF4B(2), PRPF8(5), PTBP1(3), RBM17(2), RBM5(4), RNGTT(3), RNMT(2), SF3A3(1), SF3B1(1), SF3B2(2), SF3B4(2), SNRPA1(2), SNRPB(1), SNRPD1(1), SNRPD2(1), SNRPD3(1), SNURF(1), SPOP(1), SRPK2(5), SUPT5H(2), TXNL4A(2), U2AF1(2), U2AF2(1), XRN2(3)	30589623	145	67	144	46	85	6	22	9	23	0	0.871	1.000	1.000
383	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	A4GNT(1), ALG1(2), ALG13(6), ALG6(3), ALG8(3), ALG9(1), B4GALT3(1), B4GALT4(1), B4GALT5(1), B4GALT7(1), C1GALT1C1(4), CHPF(1), CHST11(2), CHST12(2), CHST14(1), CHST3(2), CHST4(2), CHSY1(1), DPAGT1(1), EXTL1(2), EXTL3(1), FUT11(1), FUT8(3), GALNT1(1), GALNT11(2), GALNT13(1), GALNT14(3), GALNT3(1), GALNT4(2), GALNT5(2), GALNT6(1), GALNT7(2), GALNT9(4), GALNTL5(1), GANAB(4), GCNT3(1), GCNT4(1), HS2ST1(1), HS3ST2(1), HS3ST3A1(2), HS3ST3B1(1), HS3ST5(1), HS6ST2(5), MAN1A1(1), MAN1A2(1), MAN1B1(3), MAN1C1(3), MAN2A1(3), MGAT2(1), MGAT3(3), MGAT5(2), MGAT5B(1), NDST2(4), NDST3(5), NDST4(4), OGT(4), RPN1(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(1), ST6GAL1(2), ST6GALNAC1(2), UST(1), WBSCR17(5), XYLT2(1)	31238004	132	66	131	47	70	6	31	10	15	0	0.583	1.000	1.000
384	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	91	AKT1(3), AKT2(1), AKT3(3), CARD11(5), CBL(1), CBLB(5), CBLC(3), CD247(1), CD3D(2), CD4(1), CD40LG(3), CD8A(2), CD8B(1), CDC42(1), CHUK(2), FOS(2), FYN(3), HRAS(1), IFNG(1), IKBKB(2), IL5(1), ITK(1), JUN(2), LAT(1), LCP2(1), MALT1(1), MAP3K8(1), NCK1(2), NFAT5(5), NFATC1(4), NFATC2(4), NFATC3(5), NFATC4(3), NFKB1(2), NFKB2(1), NFKBIA(2), NFKBIE(2), NRAS(1), PAK1(1), PAK2(1), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PDK1(3), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(10), PIK3R3(4), PLCG1(3), PPP3CA(1), PPP3CC(1), PRKCQ(1), PTPRC(10), RASGRP1(1), RHOA(2), SOS1(5), SOS2(5), VAV1(2), VAV2(3), VAV3(3), ZAP70(2)	28491204	152	66	151	54	94	7	29	7	15	0	0.842	1.000	1.000
385	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	42	ADAM17(5), APH1A(2), CREBBP(15), CTBP1(1), CTBP2(3), DLL1(1), DLL3(1), DTX1(1), DTX3(1), DTX3L(4), DTX4(1), HES1(2), JAG1(3), JAG2(1), LFNG(2), MAML1(3), MAML2(5), MAML3(3), MFNG(1), NCOR2(6), NCSTN(2), NOTCH1(14), NOTCH2(7), NOTCH3(7), NOTCH4(6), NUMB(2), PSEN1(4), PSEN2(1), PSENEN(1), RBPJ(1), RBPJL(2), RFNG(1), SNW1(2)	18232617	111	65	109	41	51	4	34	4	17	1	0.791	1.000	1.000
386	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	ACTB(2), BAD(2), CABIN1(5), CALM1(2), CALM3(1), CAMK2B(1), CAMK4(2), CDKN1A(1), CNR1(1), CREBBP(15), EGR3(1), FOS(2), GSK3A(3), HRAS(1), IFNG(1), IL6(1), IL8(2), ITK(1), JUNB(2), KPNA5(3), MAP2K7(1), MAPK8(1), MAPK9(4), MEF2A(1), MEF2B(1), MEF2D(3), NFAT5(5), NFATC1(4), NFATC2(4), NFATC3(5), NFATC4(3), NFKB2(1), NFKBIE(2), NUP214(2), PAK1(1), PIN1(1), PPP3CC(1), PTPRC(10), RELA(7), RPL13A(2), SFN(1), SLA(1), SP1(3), SP3(2), TRAF2(1), TRPV6(2), VAV1(2), VAV2(3), VAV3(3), XPO5(2)	24955885	128	64	127	42	71	6	27	5	18	1	0.611	1.000	1.000
387	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1B(2), ACVRL1(1), AKT1(3), AURKB(2), BMPR1A(1), BMPR2(3), BUB1(4), CDKL2(2), CLK1(4), CLK2(3), CLK4(2), COL4A3BP(3), DGKA(3), DGKB(1), DGKE(1), DGKG(3), DGKH(2), DGKQ(1), DGKZ(5), INPP1(2), INPP4A(3), INPP4B(4), INPPL1(4), ITPKA(1), ITPKB(1), MAP3K10(2), NEK1(2), NEK3(1), OCRL(3), PAK4(2), PIK3C2A(4), PIK3C2B(4), PIK3C2G(5), PIK3CB(2), PIK3CG(1), PIM2(1), PLCB1(10), PLCB2(2), PLCB3(2), PLCB4(1), PLCD1(2), PLCG1(3), PLCG2(4), PLK3(1), PRKACA(2), PRKAR2A(1), PRKCA(3), PRKCD(1), PRKCE(1), PRKCG(1), PRKCH(1), PRKCQ(1), PRKCZ(1), PRKD1(4), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA4(1), RPS6KB1(1), STK11(8), TGFBR1(1)	32726316	145	64	144	53	85	7	31	13	9	0	0.846	1.000	1.000
388	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	57	BAK1(1), BFAR(3), BTK(4), CAD(8), CASP10(1), CASP3(1), DAXX(2), DEDD(1), DEDD2(1), DFFA(1), EGFR(7), EPHB2(3), FADD(1), FAF1(4), FAIM2(1), HSPB1(1), IL1A(2), IL8(2), MAP2K7(1), MAP3K1(4), MAP3K5(11), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(2), MAPK9(4), MET(2), NFAT5(5), NFKB1(2), NFKB2(1), NFKBIA(2), NFKBIE(2), PTPN13(6), RALBP1(3), RIPK1(2), ROCK1(3), SMPD1(3), TNFRSF6B(1), TP53(12), TPX2(2), TRAF2(1)	20775488	116	63	114	34	66	5	27	4	14	0	0.583	1.000	1.000
389	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	85	AK3(1), CAD(8), CANT1(1), CTPS2(2), DCK(1), DCTD(1), DHODH(1), DPYD(3), DPYS(1), ENTPD3(2), ENTPD4(1), NME6(1), NME7(1), NT5C(2), NT5C1A(2), NT5C1B(2), NT5C2(3), NT5E(1), PNPT1(1), POLA1(5), POLA2(1), POLD1(3), POLD2(1), POLD3(1), POLE(7), POLR1A(7), POLR1B(3), POLR1C(3), POLR2A(5), POLR2B(3), POLR2C(1), POLR2F(1), POLR2H(1), POLR2L(1), POLR3A(1), POLR3B(3), POLR3G(2), PRIM1(1), RFC5(2), RRM1(2), RRM2B(1), TXNRD1(2), UCK1(1), UMPS(1), UPP2(2)	23922516	96	62	96	39	49	4	23	9	11	0	0.908	1.000	1.000
390	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	APAF1(3), BAD(2), BAK1(1), BCL2L11(3), BID(1), BIRC2(2), BIRC3(1), CASP1(1), CASP10(1), CASP2(2), CASP3(1), CASP6(2), CASP9(1), CHUK(2), DFFA(1), DFFB(1), FADD(1), FAS(5), FASLG(1), GZMB(1), HELLS(1), IKBKB(2), IRF1(3), IRF2(1), IRF5(2), IRF6(2), IRF7(3), JUN(2), MAP3K1(4), MDM2(1), MYC(1), NFKB1(2), NFKBIA(2), NFKBIE(2), PLEKHG5(4), PRF1(1), RELA(7), RIPK1(2), TNFRSF10B(1), TNFRSF1A(4), TNFRSF1B(2), TNFRSF21(2), TNFSF10(2), TP53(12), TP73(6), TRAF1(1), TRAF2(1), TRAF3(3)	16051472	109	61	106	32	61	6	19	6	17	0	0.561	1.000	1.000
391	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	96	AKT1(3), AKT2(1), AKT3(3), CD14(3), CD40(1), CHUK(2), CXCL9(1), FADD(1), FOS(2), IFNA10(1), IFNA4(1), IFNA5(1), IFNA6(1), IFNA8(1), IFNAR1(3), IFNAR2(2), IKBKB(2), IKBKE(1), IL12A(2), IL12B(2), IL6(1), IL8(2), IRAK1(3), IRF5(2), IRF7(3), JUN(2), LY96(2), MAP2K1(2), MAP2K3(2), MAP2K7(1), MAP3K8(1), MAPK11(2), MAPK13(1), MAPK3(1), MAPK8(1), MAPK9(4), NFKB1(2), NFKB2(1), NFKBIA(2), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(10), PIK3R3(4), RAC1(1), RELA(7), RIPK1(2), SPP1(3), STAT1(2), TBK1(3), TICAM1(4), TLR1(1), TLR2(2), TLR3(5), TLR4(2), TLR5(2), TLR7(4), TLR8(4), TLR9(2), TOLLIP(1), TRAF3(3), TRAF6(1)	24764844	136	61	134	40	82	7	25	6	16	0	0.297	1.000	1.000
392	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(2), C1QC(1), C1R(1), C1S(1), C2(1), C3(6), C4BPA(2), C5(3), C5AR1(2), C6(5), C7(3), C8B(2), C8G(3), C9(1), CD55(1), CFB(1), CFH(6), CFI(2), CPB2(3), CR1(4), CR2(3), F10(1), F11(1), F12(1), F13A1(2), F13B(2), F2R(1), F5(7), F7(2), F8(9), F9(3), FGA(6), FGG(1), KLKB1(2), MASP1(1), MASP2(2), PLAT(3), PLAU(1), PLG(1), PROS1(2), SERPINC1(1), SERPIND1(2), SERPINF2(1), SERPING1(2), TFPI(1), THBD(2), VWF(6)	26070293	116	60	115	36	61	8	24	11	11	1	0.627	1.000	1.000
393	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	84	ANPEP(1), CD14(3), CD19(1), CD1A(2), CD1B(1), CD1E(2), CD22(3), CD34(2), CD36(2), CD3D(2), CD4(1), CD44(2), CD5(1), CD55(1), CD8A(2), CD8B(1), CR1(4), CR2(3), CSF1R(2), CSF3R(3), DNTT(1), EPOR(1), FCGR1A(1), FLT3(3), GP5(1), GP9(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(1), IL11(1), IL11RA(2), IL1A(2), IL1R1(2), IL1R2(2), IL3RA(2), IL4R(5), IL5(1), IL5RA(2), IL6(1), IL6R(3), IL9R(3), ITGA1(3), ITGA2(3), ITGA2B(1), ITGA3(1), ITGA4(6), ITGA5(2), ITGAM(4), ITGB3(3), KIT(3), KITLG(1), MME(2), THPO(1), TPO(6)	23771930	112	60	112	41	56	8	28	6	14	0	0.762	1.000	1.000
394	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	59	AKT1(3), AKT2(1), AKT3(3), BAD(2), CDC42(1), CDK2(1), CREB1(2), CREB3(1), CREB5(5), ERBB4(4), F2RL2(1), GAB1(2), GSK3A(3), INPPL1(4), IRS1(2), IRS4(2), MET(2), MYC(1), NOLC1(2), PAK1(1), PAK2(1), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PARD3(8), PARD6A(1), PDK1(3), PIK3CD(1), PPP1R13B(2), PREX1(10), PTK2(2), PTPN1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), SFN(1), SOS1(5), SOS2(5), TSC1(2), TSC2(6), YWHAE(2), YWHAQ(2), YWHAZ(3)	20921761	112	60	111	39	68	4	21	7	12	0	0.752	1.000	1.000
395	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	79	AIFM1(2), AKT1(3), AKT2(1), AKT3(3), APAF1(3), ATM(11), BAD(2), BID(1), BIRC2(2), BIRC3(1), CAPN1(5), CASP10(1), CASP3(1), CASP6(2), CASP9(1), CHUK(2), CSF2RB(2), DFFA(1), DFFB(1), FADD(1), FAS(5), FASLG(1), IKBKB(2), IL1A(2), IL1R1(2), IL1RAP(5), IL3RA(2), IRAK1(3), IRAK2(1), IRAK3(2), NFKB1(2), NFKB2(1), NFKBIA(2), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(10), PIK3R3(4), PPP3CA(1), PPP3CC(1), PRKACA(2), PRKAR2A(1), RELA(7), RIPK1(2), TNFRSF10A(1), TNFRSF10B(1), TNFRSF10C(1), TNFRSF10D(1), TNFRSF1A(4), TNFSF10(2), TP53(12), TRAF2(1)	23552194	131	58	126	44	78	7	20	7	19	0	0.705	1.000	1.000
396	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	44	AKT1(3), AKT2(1), AKT3(3), BAD(2), BCR(2), BLNK(2), BTK(4), CD19(1), CD22(3), CR2(3), DAG1(3), FLOT2(2), GSK3A(3), INPP5D(4), ITPR1(8), ITPR2(5), ITPR3(2), MAP4K1(3), MAPK3(1), NFATC1(4), NFATC2(4), PDK1(3), PIK3CD(1), PIK3R1(10), PLCG2(4), PPP1R13B(2), PPP3CA(1), PPP3CC(1), PTPRC(10), SOS1(5), SOS2(5), SYK(1), VAV1(2)	20425452	108	57	107	35	58	6	20	9	15	0	0.553	1.000	1.000
397	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	62	APAF1(3), ATM(11), ATR(6), BAI1(6), BBC3(1), BID(1), CASP3(1), CASP9(1), CCNB3(4), CCND1(1), CDK2(1), CDKN1A(1), CHEK1(1), CHEK2(1), DDB2(1), EI24(1), FAS(5), GADD45B(1), GTSE1(1), MDM2(1), PERP(1), PPM1D(2), RCHY1(1), RFWD2(2), RRM2B(1), SERPINB5(1), SESN2(3), SESN3(3), SFN(1), THBS1(2), TNFRSF10B(1), TP53(12), TP53I3(1), TP73(6), TSC2(6)	18336843	92	56	89	36	59	0	17	5	11	0	0.939	1.000	1.000
398	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	70	B2M(3), CALR(3), CANX(3), CD4(1), CD74(1), CD8A(2), CD8B(1), CIITA(1), CREB1(2), CTSS(3), HLA-C(5), HLA-DMA(2), HLA-DMB(2), HLA-DPB1(3), HLA-DQA1(3), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(1), HLA-E(2), HLA-F(2), HLA-G(2), HSP90AA1(3), HSP90AB1(1), IFI30(1), IFNA10(1), IFNA4(1), IFNA5(1), IFNA6(1), IFNA8(1), KIR2DL1(1), KIR2DL3(1), KIR3DL1(1), KIR3DL2(1), KIR3DL3(1), KLRC4(1), KLRD1(2), NFYA(3), NFYB(1), NFYC(1), PDIA3(1), RFX5(1), TAP1(3), TAP2(2), TAPBP(5)	11412134	81	56	79	41	46	1	14	5	14	1	0.988	1.000	1.000
399	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	61	AKT1(3), AKT2(1), AKT3(3), BLNK(2), BTK(4), CARD11(5), CD19(1), CD22(3), CD72(1), CD79A(1), CD79B(1), CHUK(2), CR2(3), FOS(2), HRAS(1), IKBKB(2), INPP5D(4), JUN(2), LILRB3(3), MALT1(1), NFAT5(5), NFATC1(4), NFATC2(4), NFATC3(5), NFATC4(3), NFKB1(2), NFKB2(1), NFKBIA(2), NFKBIE(2), NRAS(1), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(10), PIK3R3(4), PLCG2(4), PPP3CA(1), PPP3CC(1), RAC1(1), RAC2(1), RAC3(1), SYK(1), VAV1(2), VAV2(3), VAV3(3)	20914639	110	56	109	38	64	4	26	5	11	0	0.693	1.000	1.000
400	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(3), ALG6(3), CCKBR(1), CCR2(1), CCR3(1), CELSR1(7), CELSR2(7), CELSR3(5), CHRM2(3), CHRM3(3), CIDEB(2), CXCR3(1), EDNRA(1), EMR2(3), EMR3(1), F2R(1), FSHR(2), GPR116(4), GPR132(1), GPR133(2), GPR143(1), GPR18(1), GPR56(2), GPR61(1), GRM1(3), GRPR(4), HRH4(2), LGR6(2), LPHN2(4), LPHN3(10), NTSR1(1), OR2M4(1), P2RY13(3), PTGFR(1), SMO(1), TAAR5(2), VN1R1(4)	19155349	95	55	95	30	41	7	26	10	11	0	0.114	1.000	1.000
401	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	49	ACTG1(5), APAF1(3), BAG4(1), BID(1), BIRC2(2), BIRC3(1), CASP2(2), CASP3(1), CASP6(2), CASP9(1), CHUK(2), DAXX(2), DFFA(1), DFFB(1), FADD(1), GSN(2), LMNB1(1), MAP2K7(1), MAP3K1(4), MAP3K5(11), MAPK8(1), MDM2(1), NFKB1(2), NFKBIA(2), NUMA1(3), PAK2(1), PRKCD(1), PRKDC(11), PSEN1(4), PSEN2(1), PTK2(2), RASA1(4), RELA(7), RIPK1(2), SPTAN1(11), TNFRSF1A(4), TNFRSF1B(2), TRAF1(1), TRAF2(1)	19403909	106	55	104	33	54	6	18	9	19	0	0.734	1.000	1.000
402	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	42	ACTR2(1), AKT1(3), AKT2(1), AKT3(3), ARHGAP4(6), ARHGEF11(8), BTK(4), CDC42(1), GDI1(2), INPPL1(4), ITPR1(8), ITPR2(5), ITPR3(2), LIMK1(4), MYLK(2), PAK1(1), PAK2(1), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PDK1(3), PIK3CD(1), PIK3CG(1), PIK3R1(10), PITX2(2), PPP1R13B(2), RACGAP1(1), ROCK1(3), ROCK2(4), RPS4X(2), SAG(1), WASF1(3), WASL(4)	19691722	101	55	100	30	56	4	16	6	19	0	0.382	1.000	1.000
403	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(4), ADCY6(4), ADCY8(4), CACNA1A(4), CACNA1B(9), GNAS(6), GNAT3(2), GNB1(1), GNB3(1), GRM4(1), ITPR3(2), KCNB1(1), PDE1A(3), PLCB2(2), PRKACA(2), SCNN1A(3), SCNN1G(3), TAS1R1(3), TAS1R2(4), TAS1R3(3), TAS2R1(1), TAS2R13(2), TAS2R16(2), TAS2R4(1), TAS2R41(2), TAS2R42(1), TAS2R43(2), TAS2R60(2), TAS2R7(2), TRPM5(2)	16761981	79	54	78	36	38	5	27	4	5	0	0.654	1.000	1.000
404	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	61	ATM(11), CCNA1(2), CCND1(1), CDC25A(2), CDK2(1), CDKN1A(1), CREB3(1), CREB3L1(1), CREB3L3(3), CREB3L4(2), E2F2(1), E2F3(3), E2F4(1), E2F5(1), E2F6(1), GBA2(1), MCM2(1), MCM5(2), MCM6(1), MCM7(3), MDM2(1), MYC(1), MYT1(4), NACA(3), PCNA(1), POLA2(1), POLE(7), PRIM1(1), RBL1(3), RPA1(4), RPA2(1), TFDP1(2), TNXB(7), TP53(12)	20888661	88	53	86	23	44	5	18	8	13	0	0.371	1.000	1.000
405	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASS(2), ACAT1(2), ACAT2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), BBOX1(4), DOT1L(6), EHHADH(1), EHMT1(5), EHMT2(3), GCDH(2), HADH(1), HSD17B10(1), HSD17B4(10), HSD3B7(1), NSD1(19), OGDH(4), OGDHL(3), PLOD1(2), PLOD3(1), RDH13(1), SETDB1(6), SHMT1(2), SHMT2(1), SUV39H1(1), SUV39H2(2), TMLHE(1)	16381948	91	53	90	30	55	3	15	8	10	0	0.594	1.000	1.000
406	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	66	ACADM(4), ACOX1(1), ACOX2(3), ACOX3(2), ACSL1(1), ACSL3(2), ACSL4(5), ACSL5(2), ACSL6(1), AQP7(1), CD36(2), CPT1A(4), CPT1B(3), CPT1C(1), CPT2(1), CYP27A1(3), CYP4A22(2), CYP7A1(2), CYP8B1(1), DBI(1), EHHADH(1), FABP1(1), FABP3(1), FABP4(1), GK(2), GK2(1), LPL(2), ME1(1), MMP1(3), NR1H3(3), PCK2(1), PDPK1(2), PPARA(1), PPARD(2), PPARG(1), RXRA(1), SCP2(1), SLC27A1(3), SLC27A2(4), SLC27A4(2), SLC27A5(7), SLC27A6(1), SORBS1(5), UBC(2)	18707384	91	53	91	32	46	8	19	4	14	0	0.531	1.000	1.000
407	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(3), ATF2(2), CDC42(1), DUSP10(1), DUSP8(1), GAB1(2), GCK(2), IL1R1(2), JUN(2), MAP2K7(1), MAP3K1(4), MAP3K10(2), MAP3K12(3), MAP3K13(1), MAP3K2(1), MAP3K3(1), MAP3K4(6), MAP3K5(11), MAP3K9(5), MAPK7(2), MAPK8(1), MAPK9(4), MYEF2(1), NFATC3(5), NR2C2(1), PAPPA(1), TP53(12), TRAF6(1), ZAK(5)	14529693	84	53	81	25	48	3	17	6	10	0	0.676	1.000	1.000
408	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	71	AKT1(3), AKT2(1), AKT3(3), BTK(4), FCER1G(1), FYN(3), GAB2(1), HRAS(1), IL5(1), INPP5D(4), LAT(1), LCP2(1), MAP2K1(2), MAP2K3(2), MAP2K7(1), MAPK11(2), MAPK13(1), MAPK3(1), MAPK8(1), MAPK9(4), MS4A2(1), NRAS(1), PDK1(3), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(10), PIK3R3(4), PLA2G12A(1), PLA2G12B(3), PLA2G2D(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLCG1(3), PLCG2(4), PRKCA(3), PRKCD(1), PRKCE(1), RAC1(1), RAC2(1), RAC3(1), SOS1(5), SOS2(5), SYK(1), VAV1(2), VAV2(3), VAV3(3)	20028956	106	52	105	36	61	4	25	9	7	0	0.573	1.000	1.000
409	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	32	AKT1(3), APC(7), AR(8), ASAH1(2), BRAF(2), CCL15(1), DAG1(3), EGFR(7), GNA11(2), GNA15(4), GNAI1(1), GNAQ(2), ITPKA(1), ITPKB(1), ITPR1(8), ITPR2(5), ITPR3(2), KCNJ5(1), KCNJ9(1), PHKA2(7), PIK3CD(1), PIK3R1(10), PITX2(2), PTX3(1)	14857875	82	52	80	23	47	4	17	6	8	0	0.298	1.000	1.000
410	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1B(2), ADH4(1), ADH6(1), ADH7(1), ADHFE1(1), AGPAT2(1), AGPAT4(1), AGPAT6(1), AKR1A1(1), AKR1B1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), CEL(3), DGAT1(2), DGAT2(1), DGKA(3), DGKB(1), DGKE(1), DGKG(3), DGKH(2), DGKI(4), DGKQ(1), DGKZ(5), GK(2), GK2(1), GLA(1), GLB1(4), GPAM(2), LCT(3), LIPA(1), LIPC(2), LIPF(1), LIPG(2), LPL(2), PNLIP(3), PNLIPRP1(3), PNLIPRP2(2), PNPLA3(1), PPAP2B(4)	17205484	80	51	80	23	35	4	21	4	16	0	0.236	1.000	1.000
411	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	70	ADH1B(2), ADH4(1), ADH6(1), ADH7(1), ADHFE1(1), AKR1C1(2), AKR1C2(1), AKR1C4(2), ALDH1A3(2), ALDH3A1(1), CYP1A1(1), CYP1A2(1), CYP2C18(3), CYP2C19(1), CYP2C9(3), CYP2E1(1), CYP2F1(1), CYP3A43(2), CYP3A5(2), CYP3A7(1), DHDH(1), GSTA2(2), GSTA3(2), GSTA4(1), GSTA5(1), GSTM2(1), GSTM4(1), GSTT1(2), GSTT2(1), GSTZ1(1), MGST3(1), UGT1A1(2), UGT1A4(1), UGT1A5(1), UGT1A6(1), UGT2A1(2), UGT2A3(3), UGT2B10(3), UGT2B11(3), UGT2B15(5), UGT2B17(3), UGT2B4(1), UGT2B7(1)	17027873	70	51	70	26	41	2	14	8	5	0	0.604	1.000	1.000
412	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	30	AKT1(3), AKT2(1), AKT3(3), BCR(2), BTK(4), CD19(1), DAPP1(1), FLOT2(2), GAB1(2), ITPR1(8), ITPR2(5), ITPR3(2), PDK1(3), PITX2(2), PLCG2(4), PPP1R13B(2), PREX1(10), PTPRC(10), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), SAG(1), SYK(1), VAV1(2)	15106668	75	51	74	20	43	3	9	6	14	0	0.239	1.000	1.000
413	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	IMPA2(2), INPP1(2), INPP4A(3), INPP4B(4), INPP5B(2), INPP5E(1), INPPL1(4), IPMK(1), ISYNA1(1), ITPK1(1), ITPKA(1), ITPKB(1), MIOX(1), OCRL(3), PI4KA(5), PI4KB(1), PIK3C3(4), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIP4K2A(1), PIP5K1A(1), PIP5K1B(1), PIP5K1C(3), PLCB1(10), PLCB2(2), PLCB3(2), PLCB4(1), PLCD1(2), PLCD3(3), PLCD4(2), PLCE1(9), PLCG1(3), PLCG2(4), PLCZ1(3), SYNJ1(2), SYNJ2(1)	20816250	91	50	91	34	53	3	14	10	11	0	0.766	1.000	1.000
414	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	45	ACOX1(1), CD36(2), CPT1B(3), CREBBP(15), DUSP1(1), EHHADH(1), FABP1(1), HSD17B4(10), JUN(2), LPL(2), MAPK3(1), ME1(1), MYC(1), NCOA1(4), NCOR1(5), NCOR2(6), NFKBIA(2), NR1H3(3), NRIP1(4), PIK3R1(10), PPARA(1), PRKAR2A(1), PRKCA(3), PTGS2(2), RELA(7), RXRA(1), SP1(3), SRA1(1), STAT5A(2), STAT5B(1)	15501677	97	50	96	29	54	4	21	6	11	1	0.455	1.000	1.000
415	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG1(5), ACTG2(1), ACTR2(1), AKT1(3), CDC42(1), FLNA(10), FLNC(11), FSCN1(2), GDI1(2), LIMK1(4), MYH2(9), MYLK(2), PAK1(1), PAK2(1), PAK3(1), PAK4(2), PAK6(3), PAK7(2), ROCK1(3), ROCK2(4), RPS4X(2), VASP(1), WASF1(3), WASL(4)	13820615	78	50	77	31	46	4	17	2	9	0	0.805	1.000	1.000
416	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	42	AKT1(3), AKT2(1), AKT3(3), BRAF(2), DDIT4(1), EIF4B(3), FIGF(1), HIF1A(5), MAPK3(1), PDPK1(2), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(10), PIK3R3(4), PRKAA2(3), RICTOR(4), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA6(6), RPS6KB1(1), RPS6KB2(1), STK11(8), TSC1(2), TSC2(6), ULK1(2), ULK2(3), VEGFA(1), VEGFC(4)	14778287	86	49	84	33	53	6	16	3	8	0	0.909	1.000	1.000
417	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3(1), CAD(8), CANT1(1), CTPS2(2), DCK(1), DCTD(1), DHODH(1), DPYD(3), DPYS(1), NT5C(2), NT5E(1), POLB(1), POLD1(3), POLD2(1), POLE(7), POLG(3), POLL(1), POLQ(13), POLR1B(3), POLR2A(5), POLR2B(3), POLR2C(1), POLR2F(1), POLR2H(1), POLR2L(1), POLRMT(5), RRM1(2), TXNRD1(2), UCK1(1), UMPS(1), UNG(2)	16642141	79	49	79	26	41	2	18	6	12	0	0.555	1.000	1.000
418	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	92	ANK2(14), B3GALT4(2), CDR1(1), DGKI(4), IL6ST(2), PIGK(2), RPL10(1), RPL11(1), RPL13A(2), RPL18(1), RPL27(1), RPL28(3), RPL29(2), RPL3(2), RPL31(1), RPL35(1), RPL36(1), RPL4(3), RPL6(2), RPL7A(2), RPL8(1), RPL9(1), RPS10(1), RPS13(2), RPS19(1), RPS2(1), RPS21(1), RPS23(1), RPS24(1), RPS25(1), RPS3A(1), RPS4X(2), RPS5(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA6(6), RPS6KB1(1), RPS6KB2(1), RPS7(1), RPS9(1), SLC36A2(3), TBC1D10C(2), UBA52(1), UBC(2)	15330004	86	49	86	31	57	3	12	1	13	0	0.657	1.000	1.000
419	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	40	AKT1(3), ASAH1(2), BRAF(2), CREB1(2), CREB3(1), CREB5(5), CREBBP(15), DAG1(3), EGR1(3), EGR3(1), EGR4(1), ELK1(2), FRS2(2), GNAQ(2), JUN(2), MAP1B(8), MAP2K7(1), MAPK3(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(2), MAPK9(4), PIK3C2G(5), PIK3CD(1), PIK3R1(10), RPS6KA3(2), TH(2)	14231746	85	49	83	28	42	3	25	3	11	1	0.649	1.000	1.000
420	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	42	CBL(1), CD3D(2), DAG1(3), EPHB2(3), ITK(1), ITPKA(1), ITPKB(1), LAT(1), LCP2(1), NCK1(2), NFAT5(5), NFKB1(2), NFKB2(1), NFKBIA(2), NFKBIE(2), PAK1(1), PAK2(1), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PLCG1(3), PTPRC(10), RASGRP1(1), RASGRP2(5), RASGRP4(5), SOS1(5), SOS2(5), VAV1(2), ZAP70(2)	15534206	76	49	76	22	41	3	19	4	9	0	0.475	1.000	1.000
421	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(3), ACSS2(2), ADH1B(2), ADH4(1), ADH6(1), ADH7(1), ADHFE1(1), AKR1A1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), ALDOA(3), ALDOB(1), ALDOC(1), DLAT(2), ENO1(3), ENO3(4), G6PC(3), G6PC2(1), GALM(1), GAPDH(1), GAPDHS(2), GCK(2), GPI(3), HK1(2), HK2(4), HK3(1), LDHAL6A(1), LDHAL6B(1), LDHC(3), PDHA1(1), PDHA2(4), PDHB(2), PGAM1(1), PGK1(1), PGK2(1), PGM3(1), PKLR(3)	16998923	74	48	73	22	43	3	13	6	9	0	0.216	1.000	1.000
422	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	66	ADAM10(2), ADAM17(5), ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1E2(1), ATP6V1F(1), CASP3(1), CDC42(1), CHUK(2), EGFR(7), F11R(2), IKBKB(2), IL8(2), JUN(2), MAPK11(2), MAPK13(1), MAPK8(1), MAPK9(4), MET(2), NFKB1(2), NFKB2(1), NFKBIA(2), NOD1(1), PAK1(1), PLCG1(3), PLCG2(4), PTPRZ1(4), RAC1(1), RELA(7), TJP1(7)	20742851	85	48	85	27	46	3	19	5	12	0	0.524	1.000	1.000
423	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	35	AKT1(3), AKT2(1), AKT3(3), ARHGEF11(8), CDC42(1), DLG4(2), GNA13(3), LPA(2), MAP3K1(4), MAP3K5(11), MAPK8(1), NFKB1(2), NFKB2(1), NFKBIA(2), NFKBIE(2), PDK1(3), PHKA2(7), PIK3CB(2), PLD1(3), PTK2(2), RDX(2), ROCK1(3), ROCK2(4), SERPINA4(2), TBXA2R(1)	14316726	75	48	73	18	42	2	17	7	7	0	0.276	1.000	1.000
424	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	66	AKT1(3), AKT2(1), AKT3(3), BAD(2), CASP9(1), CDC42(1), HRAS(1), KDR(2), MAP2K1(2), MAPK11(2), MAPK13(1), MAPK3(1), MAPKAPK2(2), MAPKAPK3(1), NFAT5(5), NFATC1(4), NFATC2(4), NFATC3(5), NFATC4(3), NOS3(6), NRAS(1), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(10), PIK3R3(4), PLA2G12A(1), PLA2G12B(3), PLA2G2D(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLCG1(3), PLCG2(4), PPP3CA(1), PPP3CC(1), PRKCA(3), PRKCG(1), PTGS2(2), PTK2(2), PXN(2), RAC1(1), RAC2(1), RAC3(1), SHC2(3), SPHK1(1), SPHK2(1), VEGFA(1)	20010633	108	47	107	38	62	4	27	5	10	0	0.618	1.000	1.000
425	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(8), ACTB(2), ACTG1(5), ARHGEF2(3), CD14(3), CDC42(1), CDH1(2), CTNNB1(5), CTTN(1), EZR(6), FYN(3), HCLS1(1), ITGB1(2), KRT18(2), LY96(2), NCK1(2), NCL(3), OCLN(1), PRKCA(3), RHOA(2), ROCK1(3), ROCK2(4), TLR4(2), TLR5(2), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3C(2), TUBA3D(1), TUBA8(2), TUBB(1), TUBB8(1), WASL(4), YWHAQ(2), YWHAZ(3)	15075089	88	47	87	33	53	2	18	7	8	0	0.866	1.000	1.000
426	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(8), ACTB(2), ACTG1(5), ARHGEF2(3), CD14(3), CDC42(1), CDH1(2), CTNNB1(5), CTTN(1), EZR(6), FYN(3), HCLS1(1), ITGB1(2), KRT18(2), LY96(2), NCK1(2), NCL(3), OCLN(1), PRKCA(3), RHOA(2), ROCK1(3), ROCK2(4), TLR4(2), TLR5(2), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3C(2), TUBA3D(1), TUBA8(2), TUBB(1), TUBB8(1), WASL(4), YWHAQ(2), YWHAZ(3)	15075089	88	47	87	33	53	2	18	7	8	0	0.866	1.000	1.000
427	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	AKT1(3), AKT2(1), AKT3(3), ASAH1(2), BRAF(2), DAG1(3), EGFR(7), EPHB2(3), ITPKA(1), ITPKB(1), ITPR1(8), ITPR2(5), ITPR3(2), KCNJ5(1), KCNJ9(1), PIK3CB(2), PITX2(2), PLCB1(10), PLCB2(2), PLCB3(2), PLCB4(1), RGS20(1), SOS1(5), SOS2(5), STAT3(2)	16841082	75	47	74	29	47	4	13	4	7	0	0.786	1.000	1.000
428	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(1), ARHGAP4(6), ARHGAP5(4), ARHGAP6(8), ARHGEF1(1), ARHGEF11(8), ARHGEF5(5), ARPC1A(2), ARPC2(3), DIAPH1(1), GSN(2), LIMK1(4), MYLK(2), OPHN1(2), PIP5K1A(1), PIP5K1B(1), PPP1R12B(3), ROCK1(3), TLN1(3), VCL(3)	13586710	63	46	63	20	38	0	12	1	12	0	0.604	1.000	1.000
429	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	37	AKT1(3), AKT2(1), AKT3(3), BAD(2), BCR(2), BLNK(2), BTK(4), CD19(1), DAG1(3), EPHB2(3), ITPKA(1), ITPKB(1), MAP2K1(2), NFAT5(5), NFKB1(2), NFKB2(1), NFKBIA(2), NFKBIE(2), PIK3CD(1), PIK3R1(10), PLCG2(4), PPP1R13B(2), SERPINA4(2), SOS1(5), SOS2(5), SYK(1), VAV1(2)	14396921	72	46	70	20	34	3	20	5	10	0	0.357	1.000	1.000
430	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(8), ATM(11), BRCA1(5), CDKN1A(1), CHEK1(1), CHEK2(1), JUN(2), MAPK8(1), MDM2(1), MRE11A(1), NFKB1(2), NFKBIA(2), RAD51(1), RBBP8(4), RELA(7), TP53(12), TP73(6)	8524661	66	45	64	18	39	1	12	3	10	1	0.816	1.000	1.000
431	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(7), CCND1(1), CTNNB1(5), FBXW2(1), FZD1(1), FZD10(2), FZD2(2), FZD3(1), FZD5(2), FZD6(2), FZD7(1), FZD8(1), JUN(2), LDLR(1), MAPK9(4), MYC(1), PAFAH1B1(2), PLAU(1), PPP2R5C(2), PPP2R5E(2), PRKCA(3), PRKCD(1), PRKCE(1), PRKCG(1), PRKCH(1), PRKCI(6), PRKCQ(1), PRKCZ(1), PRKD1(4), RAC1(1), RHOA(2), SFRP4(1), WNT1(1), WNT10A(1), WNT11(1), WNT16(1), WNT2B(1), WNT5B(2), WNT7B(4)	16916110	75	45	73	26	44	1	15	10	5	0	0.605	1.000	1.000
432	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(1), AKT1(3), CALM1(2), CALM3(1), CHRM1(1), CHRNA1(2), FLT1(7), FLT4(7), KDR(2), NOS3(6), PDE2A(2), PDE3A(5), PRKAR2A(1), PRKG2(3), RYR2(26), SLC7A1(2), SYT1(2)	12248513	73	44	72	25	35	4	21	4	9	0	0.568	1.000	1.000
433	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(1), ATP8A1(3), AVPR1A(1), AVPR1B(2), AVPR2(2), BRS3(3), CCKAR(1), CCKBR(1), CCR1(3), CCR2(1), CCR3(1), CCR4(2), CCR6(1), CCR7(1), CCR8(2), CX3CR1(2), CXCR3(1), CXCR4(3), CXCR6(1), EDNRA(1), EDNRB(2), FPR1(1), FSHR(2), GALR2(1), GALT(2), GHSR(2), GRPR(4), LHCGR(1), MC1R(1), MC2R(1), MC3R(1), MC5R(2), NPY1R(2), NPY2R(2), NPY5R(4), NTSR1(1), OPRL1(1), OPRM1(3), OXTR(3), TACR1(1), TACR2(1)	14820727	71	44	71	28	35	7	19	5	5	0	0.212	1.000	1.000
434	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	44	AKT1(3), AKT2(1), AKT3(3), BRD4(7), CAP1(1), CBL(1), CDC42(1), F2RL2(1), FLOT2(2), GSK3A(3), INPPL1(4), IRS1(2), IRS4(2), LNPEP(1), MAPK3(1), PARD3(8), PARD6A(1), PDK1(3), PIK3CD(1), PIK3R1(10), PTPN1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), SERPINB6(1), SFN(1), SORBS1(5), SOS1(5), SOS2(5), YWHAE(2), YWHAQ(2), YWHAZ(3)	15455918	87	44	86	22	54	3	12	6	12	0	0.327	1.000	1.000
435	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(2), AGPAT2(1), AGPAT4(1), AGPAT6(1), CHAT(2), CHKA(2), CHKB(3), CHPT1(1), DGKA(3), DGKB(1), DGKE(1), DGKG(3), DGKH(2), DGKI(4), DGKQ(1), DGKZ(5), ESCO1(1), ESCO2(1), ETNK1(1), ETNK2(1), GPAM(2), GPD1L(1), LCAT(3), NAT6(1), PCYT1A(2), PCYT1B(1), PEMT(1), PHOSPHO1(1), PLA2G12A(1), PLA2G12B(3), PLA2G2D(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLD1(3), PNPLA3(1), PPAP2B(4), PTDSS1(1), PTDSS2(2), SH3GLB1(2)	19157342	73	43	73	24	44	1	17	4	7	0	0.499	1.000	1.000
436	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	50	ACTA1(1), AGT(2), AKT1(3), CALM1(2), CALM3(1), CALR(3), CAMK1(2), CAMK4(2), CREBBP(15), EDN1(1), FGF2(1), HRAS(1), MAP2K1(2), MAPK3(1), MAPK8(1), MEF2C(1), MYH2(9), NFATC1(4), NFATC2(4), NFATC3(5), NFATC4(3), NPPA(1), PIK3R1(10), PPP3CA(1), PPP3CC(1), PRKAR2A(1), RPS6KB1(1), SYT1(2)	13743134	81	43	79	27	46	5	18	3	8	1	0.659	1.000	1.000
437	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	55	ADH1B(2), ADH4(1), ADH6(1), ADH7(1), ADHFE1(1), ALDH1A3(2), ALDH3A1(1), AOC2(1), AOC3(3), AOX1(3), CARM1(1), DBH(1), DCT(2), DDC(2), ESCO1(1), ESCO2(1), FAH(3), GOT2(1), GSTZ1(1), HEMK1(1), HGD(2), HPD(2), LCMT1(4), LCMT2(1), MAOA(1), MAOB(3), METTL2B(1), NAT6(1), PNPLA3(1), PRMT2(1), PRMT5(1), PRMT6(1), PRMT7(3), SH3GLB1(2), TAT(3), TH(2), TPO(6), TYR(2)	17143077	67	42	67	21	40	2	15	4	6	0	0.475	1.000	1.000
438	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP4(2), BMP5(1), BMP6(1), BMP8A(1), BTRC(1), CSNK1D(2), CSNK1G1(1), CSNK1G3(2), DHH(2), FBXW11(1), GLI1(2), GLI2(6), GLI3(4), IHH(1), LRP2(18), PRKACA(2), PTCH1(2), PTCH2(3), RAB23(1), SMO(1), STK36(1), SUFU(2), WNT1(1), WNT10A(1), WNT11(1), WNT16(1), WNT2B(1), WNT5B(2), WNT7B(4), WNT8A(1), WNT8B(3), ZIC2(2)	16990134	74	42	74	24	32	5	26	7	4	0	0.496	1.000	1.000
439	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(1), ATP5D(1), ATP5F1(3), ATP5G3(1), ATP5H(1), ATP5J(2), ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1E2(1), ATP6V1F(1), COX10(1), COX4I1(1), COX4I2(2), COX5A(2), COX6A1(1), COX7A2(1), COX8A(1), NDUFA1(1), NDUFA11(1), NDUFA5(1), NDUFA8(1), NDUFA9(1), NDUFB10(1), NDUFB11(3), NDUFB7(2), NDUFS1(1), NDUFS2(1), NDUFS3(1), NDUFS4(1), NDUFS6(1), NDUFV1(3), SDHA(4), SDHB(1), SDHD(1), UQCRB(2), UQCRC1(1), UQCRC2(3), UQCRFS1(1), UQCRQ(1)	16501760	67	41	67	25	30	3	16	3	15	0	0.694	1.000	1.000
440	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ADC(1), ALDH4A1(3), ALDH5A1(1), CAD(8), CPS1(1), EPRS(7), GAD1(4), GCLM(1), GFPT1(3), GFPT2(5), GLS2(2), GLUD1(2), GLUD2(1), GLUL(1), GMPS(2), GNPNAT1(1), GOT2(1), GPT2(2), GSR(1), NADSYN1(5), PPAT(1), QARS(2)	11554144	55	41	55	20	31	0	14	4	6	0	0.670	1.000	1.000
441	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	ACAT1(2), ACAT2(1), ACMSD(1), AFMID(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), AOC2(1), AOC3(3), AOX1(3), ASMT(1), CARM1(1), CAT(2), CYP1A1(1), CYP1A2(1), DDC(2), EHHADH(1), GCDH(2), HAAO(2), HADH(1), HEMK1(1), HSD17B10(1), HSD17B4(10), KMO(1), LCMT1(4), LCMT2(1), MAOA(1), MAOB(3), METTL2B(1), NFX1(2), OGDH(4), OGDHL(3), PRMT2(1), PRMT5(1), PRMT6(1), PRMT7(3), TPH1(2), WARS(1), WARS2(1)	17592001	77	41	77	22	46	4	14	7	6	0	0.287	1.000	1.000
442	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(3), ALPL(1), ALPP(2), ALPPL2(1), ASCC3(4), ATP13A2(5), DDX18(1), DDX19A(2), DDX23(3), DDX41(6), DDX50(1), DDX52(2), DHX58(1), ENTPD7(1), EP400(9), ERCC2(1), ERCC3(1), GGH(2), IFIH1(2), MOV10L1(4), NUDT8(1), RAD54B(2), RAD54L(3), SETX(3), SKIV2L2(5), SMARCA2(4), SMARCA5(3)	18395912	73	41	72	26	45	1	14	2	11	0	0.722	1.000	1.000
443	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(3), CARS(1), CARS2(1), DARS2(2), EPRS(7), FARS2(1), GARS(1), HARS2(1), IARS2(3), LARS(3), LARS2(1), MARS(2), MARS2(2), NARS2(3), QARS(2), RARS2(5), SARS(1), SARS2(3), TARS(2), TARS2(3), VARS(2), VARS2(1), WARS(1), WARS2(1), YARS(2), YARS2(1)	15093905	55	41	54	17	39	1	8	3	4	0	0.526	1.000	1.000
444	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	32	ACTA1(1), CRK(1), DOCK1(4), ELK1(2), FOS(2), GAB1(2), HGF(5), HRAS(1), ITGA1(3), ITGB1(2), JUN(2), MAP2K1(2), MAP4K1(3), MAPK3(1), MAPK8(1), MET(2), PAK1(1), PIK3R1(10), PTK2(2), PTK2B(3), PXN(2), RAP1A(1), RAP1B(1), RASA1(4), SOS1(5), STAT3(2)	12170686	65	41	64	20	26	5	22	5	7	0	0.645	1.000	1.000
445	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	27	ADRBK1(2), AKT1(3), AKT2(1), AKT3(3), DAG1(3), GNAQ(2), ITPKA(1), ITPKB(1), ITPR1(8), ITPR2(5), ITPR3(2), NFKB1(2), NFKB2(1), NFKBIA(2), NFKBIE(2), PDK1(3), PHKA2(7), PIK3CB(2), PITX2(2), PLD1(3), VN1R1(4)	13254740	59	41	58	21	35	3	12	5	4	0	0.626	1.000	1.000
446	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	36	ANKHD1(10), EEF1A2(1), EEF1B2(1), EEF1G(1), EEF2(2), EEF2K(2), EIF1AX(1), EIF2AK1(4), EIF2AK2(3), EIF2AK3(2), EIF2B2(2), EIF2B4(2), EIF2B5(1), EIF2S1(3), EIF2S2(2), EIF4A1(3), EIF4A2(3), EIF4G1(5), EIF4G3(4), EIF5(1), EIF5A(1), EIF5B(3), ETF1(3), GSPT2(4), PABPC3(4), PAIP1(1), SLC35A4(1)	12969557	70	41	70	21	41	3	10	6	10	0	0.701	1.000	1.000
447	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(3), BAK1(1), BID(1), BIRC2(2), BIRC3(1), CASP2(2), CASP3(1), CASP6(2), CASP9(1), FADD(1), FAS(5), FASLG(1), GZMB(1), JUN(2), MAP3K1(4), MCL1(1), MDM2(1), MYC(1), NFKB1(2), NFKBIA(2), PARP1(2), PRF1(1), RELA(7), RIPK1(2), TNFRSF1A(4), TNFRSF1B(2), TNFSF10(2), TP53(12), TRAF1(1), TRAF2(1)	10325802	69	40	67	21	40	4	12	4	9	0	0.600	1.000	1.000
448	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(2), CDK2(1), CDT1(2), DIAPH2(4), GMNN(2), MCM10(4), MCM2(1), MCM5(2), MCM6(1), MCM7(3), NACA(3), PCNA(1), POLA2(1), POLD1(3), POLD2(1), POLD3(1), POLE(7), PRIM1(1), RFC1(2), RFC2(1), RFC3(1), RFC5(2), RPA1(4), RPA2(1), RPA4(3), UBA52(1), UBC(2)	14766741	58	40	58	18	36	3	8	2	9	0	0.574	1.000	1.000
449	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	36	CALM1(2), CALM3(1), CAMK1(2), ELK1(2), FPR1(1), GNA15(4), GNB1(1), GNGT1(1), HRAS(1), MAP2K1(2), MAP2K3(2), MAP3K1(4), MAPK3(1), NCF2(2), NFATC1(4), NFATC2(4), NFATC3(5), NFATC4(3), NFKB1(2), NFKBIA(2), PAK1(1), PIK3C2G(5), PLCB1(10), PPP3CA(1), PPP3CC(1), RAC1(1), RELA(7), SYT1(2)	10977983	74	40	74	22	46	3	15	6	4	0	0.511	1.000	1.000
450	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	B3GALNT1(1), B3GALT1(2), B3GALT4(2), B3GALT5(2), B3GNT3(1), B3GNT5(3), B4GALT3(1), B4GALT4(1), B4GALT6(1), FUT1(2), FUT2(3), FUT6(1), FUT9(3), GCNT2(3), PIGA(2), PIGG(2), PIGH(1), PIGK(2), PIGM(1), PIGN(1), PIGO(2), PIGQ(2), PIGU(2), PIGX(1), ST3GAL1(2), ST3GAL2(1), ST3GAL3(1), ST3GAL5(2), ST3GAL6(1), ST6GALNAC3(3), ST6GALNAC5(1), ST6GALNAC6(3), ST8SIA1(2), ST8SIA5(1), UGCG(2)	14221040	61	40	61	21	28	6	17	3	7	0	0.371	1.000	1.000
451	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	34	AKT1(3), CDC42(1), CREB1(2), CREB3(1), CREB5(5), DUSP1(1), DUSP10(1), EEF2K(2), ELK1(2), HSPB1(1), IL1R1(2), MAP2K3(2), MAP3K10(2), MAP3K4(6), MAP3K5(11), MAPK11(2), MAPK13(1), MAPKAPK2(2), MAPKAPK5(1), MKNK1(1), MKNK2(2), MYEF2(1), NFKB1(2), NR2C2(1), TRAF6(1)	9563390	56	40	55	19	30	1	16	3	6	0	0.738	1.000	1.000
452	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	36	AGT(2), CALM1(2), CALM3(1), CAMK2A(3), CAMK2B(1), CAMK2D(2), FYN(3), GNA11(2), GNAI1(1), GNB1(1), GNGT1(1), HRAS(1), JAK2(6), MAP2K1(2), MAPK3(1), MAPK8(1), MAPT(2), MYLK(2), PLCG1(3), PRKCA(3), PTK2B(3), SOS1(5), STAT1(2), STAT3(2), STAT5A(2), SYT1(2)	12023317	56	39	56	18	29	3	17	2	4	1	0.492	1.000	1.000
453	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	25	CASP10(1), CASP3(1), CASP6(2), DAXX(2), DFFA(1), DFFB(1), FADD(1), FAF1(4), JUN(2), LMNB1(1), MAP3K1(4), MAPK8(1), PAK1(1), PAK2(1), PRKDC(11), PTPN13(6), SPTAN1(11)	11499221	51	39	49	25	27	1	8	3	12	0	0.996	1.000	1.000
454	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(11), ATR(6), BRCA1(5), CDC25A(2), CDC25B(4), CDC25C(2), CDKN1A(1), CHEK1(1), CHEK2(1), MDM2(1), MYT1(4), PRKDC(11), RPS6KA1(1), TP53(12), YWHAQ(2)	11131378	64	39	61	14	48	0	8	3	5	0	0.351	1.000	1.000
455	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(2), AGPAT2(1), AGPAT4(1), AGPS(2), CHAT(2), CHKA(2), CHKB(3), CLC(1), CPT1B(3), DGKA(3), DGKB(1), DGKE(1), DGKG(3), DGKH(2), DGKQ(1), DGKZ(5), ETNK1(1), LCAT(3), PAFAH1B1(2), PCYT1A(2), PCYT1B(1), PEMT(1), PLA2G4A(3), PLA2G6(2), PLCB2(2), PLCG1(3), PLCG2(4), PPAP2B(4)	14610122	61	39	61	20	37	2	14	4	4	0	0.388	1.000	1.000
456	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	41	CALM1(2), CALM3(1), CD3D(2), ELK1(2), FOS(2), FYN(3), HRAS(1), JUN(2), LAT(1), MAP2K1(2), MAP3K1(4), MAPK3(1), MAPK8(1), NFATC1(4), NFATC2(4), NFATC3(5), NFATC4(3), NFKB1(2), NFKBIA(2), PIK3R1(10), PLCG1(3), PPP3CA(1), PPP3CC(1), PRKCA(3), RAC1(1), RASA1(4), RELA(7), SOS1(5), SYT1(2), VAV1(2), ZAP70(2)	13112482	85	39	85	25	46	6	21	4	8	0	0.552	1.000	1.000
457	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	24	BRCA1(5), CARM1(1), CCND1(1), CREBBP(15), ERCC3(1), ESR1(1), GRIP1(9), GTF2A1(1), GTF2E1(1), HDAC3(3), HDAC4(3), HDAC5(2), HDAC6(4), MEF2C(1), NCOR2(6), NR0B1(2), NRIP1(4), POLR2A(5), SRA1(1), TBP(1)	12409802	67	38	66	20	34	1	19	5	6	2	0.492	1.000	1.000
458	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	CEBPA(2), CHUK(2), DAXX(2), EGF(1), EGFR(7), ETS2(1), FOS(2), HOXA7(1), HRAS(1), IKBKB(2), JUN(2), MAP2K1(2), MAP2K3(2), MAP2K7(1), MAP3K1(4), MAP3K5(11), MAPK13(1), MAPK3(1), MAPK8(1), NFKB1(2), NFKBIA(2), PRKCA(3), PRKCD(1), PRKCE(1), PRKCG(1), PRKCH(1), PRKCQ(1), RELA(7), RIPK1(2), SP1(3), TNFRSF1A(4), TNFRSF1B(2), TRAF2(1)	13981567	77	38	77	25	49	3	15	4	6	0	0.543	1.000	1.000
459	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	30	ACTR2(1), AKT1(3), DAG1(3), DGKA(3), ITGA9(2), ITPKA(1), ITPKB(1), ITPR1(8), ITPR2(5), ITPR3(2), MAP2K1(2), MAPK3(1), PAK1(1), PDE3A(5), PIK3C2G(5), PIK3CD(1), PIK3R1(10), RPS4X(2), VASP(1)	13609888	57	38	56	21	33	2	13	2	7	0	0.715	1.000	1.000
460	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	22	AKT1(3), APC(7), ASAH1(2), DAG1(3), DLG4(2), EPHB2(3), GNAI1(1), GNAQ(2), ITPR1(8), ITPR2(5), ITPR3(2), KCNJ5(1), KCNJ9(1), PITX2(2), PTX3(1), RAC1(1), RYR1(10)	13244721	54	38	52	19	31	2	12	3	6	0	0.572	1.000	1.000
461	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(3), APAF1(3), ATM(11), BAD(2), BID(1), CASP3(1), CASP6(2), CASP9(1), EIF2S1(3), PRKCA(3), PTK2(2), PXN(2), STAT1(2), TLN1(3), TP53(12)	8062868	51	37	48	13	32	1	9	2	7	0	0.408	1.000	1.000
462	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	21	ARFIP2(2), CDK5R1(1), CHN1(2), LIMK1(4), MAP3K1(4), MYLK(2), NCF2(2), PAK1(1), PDGFRA(2), PIK3R1(10), PLD1(3), PPP1R12B(3), RAC1(1), RALBP1(3), RPS6KB1(1), TRIO(7), VAV1(2), WASF1(3)	9565736	53	37	53	14	23	3	14	6	7	0	0.440	1.000	1.000
463	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ACAT1(2), ACAT2(1), ACMSD(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), AOC2(1), AOC3(3), AOX1(3), ASMT(1), CAT(2), CYP19A1(1), CYP1A1(1), CYP1A2(1), CYP2A13(1), CYP2A6(2), CYP2A7(5), CYP2C18(3), CYP2C19(1), CYP2C9(3), CYP2E1(1), CYP2F1(1), CYP2J2(2), CYP3A5(2), CYP3A7(1), DDC(2), EHHADH(1), GCDH(2), HAAO(2), KMO(1), MAOA(1), MAOB(3), SDS(1), TPH1(2), WARS(1), WARS2(1)	15999638	69	37	69	21	46	3	13	4	3	0	0.240	1.000	1.000
464	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(11), ATR(6), BRCA1(5), BRCA2(6), CHEK1(1), CHEK2(1), FANCA(4), FANCD2(3), FANCF(1), FANCG(1), MRE11A(1), RAD17(1), RAD51(1), TP53(12)	12847156	54	36	52	11	34	0	8	3	9	0	0.380	1.000	1.000
465	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	35	BTK(4), CALM1(2), CALM3(1), ELK1(2), FCER1G(1), FOS(2), HRAS(1), JUN(2), MAP2K1(2), MAP2K7(1), MAP3K1(4), MAPK3(1), MAPK8(1), NFATC1(4), NFATC2(4), NFATC3(5), NFATC4(3), PAK2(1), PIK3R1(10), PLA2G4A(3), PLCG1(3), PPP3CA(1), PPP3CC(1), SOS1(5), SYK(1), SYT1(2), VAV1(2)	11478476	69	36	69	21	37	4	16	5	7	0	0.624	1.000	1.000
466	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	22	ABL1(8), ATM(11), ATR(6), CCNA1(2), CCND1(1), CDC25A(2), CDK2(1), CDKN1A(1), TFDP1(2), TGFB2(1), TGFB3(2), TP53(12)	7998532	49	36	47	14	28	1	9	4	7	0	0.647	1.000	1.000
467	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ALDH4A1(3), ALDH5A1(1), CAD(8), CPS1(1), EPRS(7), GAD1(4), GCLM(1), GFPT1(3), GLS2(2), GLUD1(2), GLUL(1), GMPS(2), GOT2(1), GPT2(2), NADSYN1(5), PPAT(1), QARS(2)	9684260	46	36	46	15	26	0	11	4	5	0	0.565	1.000	1.000
468	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(5), ACTG2(1), ADCY3(1), ADCY9(8), ARF4(1), ARF6(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(1), ATP6V1C2(1), ATP6V1E2(1), ATP6V1F(1), GNAS(6), PDIA4(1), PLCG1(3), PLCG2(4), PRKCA(3), SEC61A2(2), TRIM23(1)	10761575	49	36	49	18	29	0	11	3	6	0	0.563	1.000	1.000
469	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	INPP1(2), INPP4A(3), INPP4B(4), INPPL1(4), ITPKA(1), ITPKB(1), MIOX(1), OCRL(3), PIK3C2A(4), PIK3C2B(4), PIK3C2G(5), PIK3CB(2), PIK3CG(1), PLCB1(10), PLCB2(2), PLCB3(2), PLCB4(1), PLCD1(2), PLCG1(3), PLCG2(4)	12435702	59	36	59	21	34	3	13	4	5	0	0.696	1.000	1.000
470	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(4), COL4A2(4), COL4A3(4), COL4A4(2), COL4A5(3), COL4A6(4), F10(1), F11(1), F12(1), F2R(1), F5(7), F8(9), F9(3), FGA(6), FGG(1), KLKB1(2), PROS1(2), SERPINC1(1), SERPING1(2)	13196643	58	36	57	20	29	5	14	3	6	1	0.932	1.000	1.000
471	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	38	ATF2(2), CDC42(1), CREB1(2), DAXX(2), DDIT3(1), ELK1(2), HRAS(1), HSPB1(1), MAP3K1(4), MAP3K5(11), MAP3K9(5), MAPKAPK2(2), MAPKAPK5(1), MAX(2), MEF2A(1), MEF2B(1), MEF2C(1), MEF2D(3), MKNK1(1), MYC(1), PLA2G4A(3), RAC1(1), RIPK1(2), RPS6KA5(2), STAT1(2), TGFB2(1), TGFB3(2), TGFBR1(1), TRAF2(1)	10735166	60	36	60	18	36	3	11	6	4	0	0.654	1.000	1.000
472	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	30	A1BG(1), AKT1(3), AKT2(1), AKT3(3), BAD(2), BTK(4), DAPP1(1), GSK3A(3), INPP5D(4), PDK1(3), PPP1R13B(2), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), SFN(1), SOS1(5), SOS2(5), YWHAE(2), YWHAQ(2), YWHAZ(3)	9464598	51	36	50	16	28	1	9	6	7	0	0.681	1.000	1.000
473	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	45	APAF1(3), BAD(2), CASP1(1), CASP10(1), CASP2(2), CASP3(1), CASP6(2), CASP9(1), CD40(1), CD40LG(3), DAXX(2), DFFA(1), DFFB(1), FADD(1), FAS(5), FASLG(1), IKBKE(1), MCL1(1), NFKB1(2), NFKBIA(2), NGFR(1), NR3C1(4), PTPN13(6), RIPK1(2), TFG(1), TNFRSF1A(4), TNFRSF1B(2), TRAF1(1), TRAF2(1), TRAF3(3), TRAF6(1)	12167948	60	35	58	20	35	3	7	2	13	0	0.806	1.000	1.000
474	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	13	ABL1(8), MDM2(1), MYC(1), PIK3R1(10), POLR1A(7), POLR1B(3), POLR1C(3), RAC1(1), TBX2(1), TP53(12), TWIST1(1)	4450675	48	35	47	13	25	1	13	3	6	0	0.417	1.000	1.000
475	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(2), BTK(4), CALM1(2), CALM3(1), CD79A(1), CD79B(1), ELK1(2), FOS(2), HRAS(1), JUN(2), MAP2K1(2), MAP3K1(4), MAPK3(1), MAPK8(1), NFATC1(4), NFATC2(4), NFATC3(5), NFATC4(3), PLCG1(3), PPP3CA(1), PPP3CC(1), PRKCA(3), RAC1(1), SOS1(5), SYK(1), SYT1(2), VAV1(2)	10969230	61	35	61	20	34	4	16	3	4	0	0.680	1.000	1.000
476	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(3), ALDOB(1), ALDOC(1), DLAT(2), ENO1(3), ENO3(4), G6PC(3), GAPDH(1), GAPDHS(2), GCK(2), GOT2(1), GPI(3), HK1(2), HK2(4), HK3(1), LDHAL6B(1), LDHC(3), MDH1(1), MDH2(1), PC(1), PDHA1(1), PDHA2(4), PDHB(2), PDHX(2), PGAM1(1), PGK1(1), PGK2(1), PKLR(3)	12431282	55	35	54	17	29	3	11	4	8	0	0.300	1.000	1.000
477	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(3), ADSS(1), ADSSL1(2), AGXT(1), ASL(2), ASPA(1), ASS1(2), CAD(8), CRAT(1), DARS2(2), DDO(1), DLAT(2), GAD1(4), GOT2(1), GPT2(2), NARS2(3), PC(1), PDHA1(1), PDHA2(4), PDHB(2)	11133831	44	35	43	14	21	1	15	3	4	0	0.518	1.000	1.000
478	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(3), AASS(2), ACAT1(2), ACAT2(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), BBOX1(4), DOT1L(6), EHHADH(1), EHMT1(5), EHMT2(3), GCDH(2), PLOD1(2), PLOD3(1), SDS(1), SHMT1(2), SHMT2(1), TMLHE(1)	10249203	50	35	50	16	31	1	8	4	6	0	0.497	1.000	1.000
479	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	21	CHUK(2), CREBBP(15), DUSP1(1), IKBKB(2), IL8(2), MAP2K3(2), MAPK11(2), NFKB1(2), NFKBIA(2), NR3C1(4), RELA(7), TGFBR1(1), TGFBR2(5), TLR2(2)	7197040	49	35	48	16	25	3	9	2	9	1	0.737	1.000	1.000
480	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	25	BAG4(1), CASP2(2), CASP3(1), DFFA(1), DFFB(1), FADD(1), JUN(2), LMNB1(1), MADD(7), MAP3K1(4), MAPK8(1), PAK1(1), PAK2(1), PRKDC(11), RIPK1(2), SPTAN1(11), TNFRSF1A(4), TRAF2(1)	10495878	53	35	51	23	29	2	7	3	12	0	0.967	1.000	1.000
481	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(1), G6PC(3), G6PC2(1), GAA(4), GALK1(2), GALK2(1), GALT(2), GANC(1), GCK(2), GLA(1), GLB1(4), HK1(2), HK2(4), HK3(1), HSD3B7(1), LCT(3), MGAM(12), PGM3(1), RDH13(1), UGP2(2)	11304369	49	34	48	19	25	5	8	3	8	0	0.610	1.000	1.000
482	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(3), AKT2(1), AKT3(3), APC(7), AXIN2(2), CTNNB1(5), DACT1(3), DKK1(1), DKK3(1), FSTL1(2), GSK3A(3), LRP1(5), MVP(2), NKD1(1), NKD2(1), PIN1(1), PSEN1(4), PTPRA(2), SENP2(1), WIF1(1)	11808799	49	34	46	26	28	1	8	8	4	0	0.990	1.000	1.000
483	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	EGF(1), EGFR(7), ELK1(2), FOS(2), HRAS(1), JAK1(1), JUN(2), MAP2K1(2), MAP3K1(4), MAPK3(1), MAPK8(1), PIK3R1(10), PLCG1(3), PRKCA(3), RASA1(4), SOS1(5), STAT1(2), STAT3(2), STAT5A(2)	10265422	55	33	55	22	26	2	17	3	7	0	0.894	1.000	1.000
484	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2A1(1), GTF2A2(1), GTF2E1(1), GTF2H3(1), GTF2H4(1), GTF2I(3), GTF2IRD1(2), TAF1(8), TAF10(1), TAF1L(11), TAF2(1), TAF4(4), TAF5(2), TAF5L(2), TAF6(1), TAF6L(2), TAF7L(4), TAF9(4), TAF9B(1), TBPL1(2), TBPL2(1)	10377708	54	33	54	17	26	3	10	8	7	0	0.759	1.000	1.000
485	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	34	ACTA1(1), ACTN1(1), ACTN2(2), BCR(2), CAPN1(5), CAPNS1(1), FYN(3), HRAS(1), ITGA1(3), ITGB1(2), JUN(2), MAP2K1(2), MAPK3(1), MAPK8(1), PPP1R12B(3), PTK2(2), PXN(2), RAP1A(1), ROCK1(3), SOS1(5), TLN1(3), VCL(3), ZYX(1)	13614143	50	33	50	23	21	3	13	3	10	0	0.955	1.000	1.000
486	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	32	CD14(3), CHUK(2), ELK1(2), FOS(2), IKBKB(2), IRAK1(3), JUN(2), LY96(2), MAP2K3(2), MAP3K1(4), MAPK8(1), NFKB1(2), NFKBIA(2), PPARA(1), RELA(7), TLR10(3), TLR2(2), TLR3(5), TLR4(2), TLR7(4), TLR9(2), TOLLIP(1), TRAF6(1)	10721358	57	33	57	18	33	5	10	4	5	0	0.603	1.000	1.000
487	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH4A1(3), ALDH9A1(2), AMD1(5), AOC2(1), AOC3(3), ASL(2), CKB(1), CKM(1), CKMT2(2), CPS1(1), DAO(1), GLUD1(2), GOT2(1), MAOA(1), MAOB(3), NOS1(2), NOS3(6), ODC1(2), OTC(1), P4HA2(3), P4HB(2), SMS(1)	12910680	58	32	58	19	35	0	10	5	8	0	0.448	1.000	1.000
488	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	30	APAF1(3), BID(1), BIRC2(2), BIRC3(1), CASP10(1), CASP3(1), CASP6(2), CASP9(1), CHUK(2), DFFA(1), DFFB(1), FADD(1), GAS2(2), NFKB1(2), NFKBIA(2), RELA(7), RIPK1(2), SPTAN1(11), TNFRSF10A(1), TNFRSF10B(1), TNFSF10(2), TRAF2(1)	9339355	48	32	47	16	24	3	9	3	9	0	0.746	1.000	1.000
489	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), CHIA(3), CYB5R1(2), CYB5R3(1), GFPT1(3), GFPT2(5), GNE(3), GNPNAT1(1), HEXB(2), HK1(2), HK2(4), HK3(1), MTMR1(3), MTMR2(1), MTMR6(1), NPL(1), PGM3(1), PHPT1(1), UAP1(2)	8455895	38	32	38	13	20	2	7	2	7	0	0.646	1.000	1.000
490	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(3), ACADS(3), ACAT1(2), ACAT2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH5A1(1), ALDH9A1(2), BDH1(1), DDHD1(2), EHHADH(1), GAD1(4), HADH(1), HMGCS1(1), HSD17B10(1), HSD17B4(10), HSD3B7(1), L2HGDH(1), PDHA1(1), PDHA2(4), PDHB(2), PLA1A(2), PPME1(2), RDH13(1)	11845435	54	32	53	15	30	4	7	8	5	0	0.313	1.000	1.000
491	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	23	ATF2(2), BCR(2), BLNK(2), ELK1(2), FOS(2), HRAS(1), JUN(2), MAP2K1(2), MAP3K1(4), MAPK3(1), MAPK8IP3(2), PAPPA(1), RAC1(1), RPS6KA1(1), RPS6KA3(2), SOS1(5), SYK(1), VAV1(2), VAV2(3), VAV3(3)	9155985	41	32	41	17	20	2	11	3	5	0	0.877	1.000	1.000
492	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	24	APC(7), ASAH1(2), CASP3(1), CERK(3), CREB1(2), CREB3(1), CREB5(5), DAG1(3), EPHB2(3), FOS(2), GNAQ(2), ITPKA(1), ITPKB(1), JUN(2), MAP2K7(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(2), MAPK9(4)	7990330	45	32	44	13	27	0	13	2	3	0	0.500	1.000	1.000
493	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	AGT(2), AGTR1(1), ATF2(2), CALM1(2), CALM3(1), EGFR(7), ELK1(2), GNAQ(2), HRAS(1), JUN(2), MAP2K1(2), MAP3K1(4), MAPK3(1), MAPK8(1), MEF2A(1), MEF2B(1), MEF2C(1), MEF2D(3), PAK1(1), PRKCA(3), PTK2(2), PTK2B(3), RAC1(1), SOS1(5), SYT1(2)	9771134	53	31	53	14	26	6	12	4	5	0	0.409	1.000	1.000
494	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	21	AKT1(3), BCR(2), FOS(2), HRAS(1), JAK2(6), JUN(2), MAP2K1(2), MAP3K1(4), MAPK3(1), MAPK8(1), MYC(1), PIK3R1(10), SOS1(5), STAT1(2), STAT5A(2), STAT5B(1)	7376589	45	31	44	14	21	3	11	3	6	1	0.637	1.000	1.000
495	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B4GALT5(1), C1GALT1C1(4), GALNT1(1), GALNT11(2), GALNT13(1), GALNT14(3), GALNT3(1), GALNT4(2), GALNT5(2), GALNT6(1), GALNT7(2), GALNT9(4), GALNTL5(1), GCNT3(1), GCNT4(1), OGT(4), ST3GAL1(2), ST3GAL2(1), ST6GALNAC1(2), WBSCR17(5)	9442426	41	31	41	17	21	3	8	4	5	0	0.838	1.000	1.000
496	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	38	ANAPC1(2), ANAPC2(4), ANAPC5(1), ANAPC7(1), BTRC(1), CDC16(1), CDC20(2), CDC27(3), CUL1(4), CUL2(2), CUL3(1), FBXW11(1), FZR1(2), ITCH(2), RBX1(1), SMURF2(2), UBA1(2), UBE2D1(1), UBE2E1(2), WWP2(4)	11452207	39	31	39	16	24	0	5	2	7	1	0.949	1.000	1.000
497	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(3), ADRA1B(2), ADRA1D(1), ADRA2C(1), ADRB2(2), CHRM1(1), CHRM2(3), CHRM3(3), CHRM4(1), CHRM5(1), DRD3(2), HRH1(2), HRH2(1), HTR1A(4), HTR1B(2), HTR1D(1), HTR1F(2), HTR2B(2), HTR2C(2), HTR4(1), HTR5A(1), HTR6(3), HTR7(2)	7363484	43	31	43	31	19	1	17	2	4	0	0.960	1.000	1.000
498	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	ERCC3(1), GTF2A2(1), GTF2E1(1), GTF2H4(1), POLR1A(7), POLR1B(3), POLR2A(5), POLR2B(3), POLR2C(1), POLR2F(1), POLR2H(1), POLR3B(3), POLR3D(1), POLR3E(3), TAF5(2), TAF6(1), TAF9(4), TBP(1)	10091946	40	31	40	27	26	3	3	3	4	1	1.000	1.000	1.000
499	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	31	DUSP1(1), GORASP1(1), MAP2K7(1), MAPK11(2), MAPK13(1), MAPK3(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(2), MAPK9(4), MAPKAPK5(1), NFKB1(2), NFKB2(1), NFKBIA(2), NFKBIE(2), PIK3CD(1), PIK3R1(10), SYT1(2), TRAF2(1), TRAF3(3), TRAF5(1), TRAF6(1)	9003930	43	31	42	16	25	2	10	1	5	0	0.769	1.000	1.000
500	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	23	AKT1(3), AKT2(1), AKT3(3), BAD(2), GSK3A(3), IL4R(5), IRS1(2), JAK1(1), JAK3(4), MAP4K1(3), MAPK3(1), PDK1(3), PIK3CD(1), PIK3R1(10), PPP1R13B(2), SOS1(5), SOS2(5), STAT6(3)	9436557	57	31	56	17	29	3	14	3	8	0	0.466	1.000	1.000
501	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	BAD(2), BRAF(2), CREB1(2), CREB3(1), CREB5(5), DUSP9(1), EEF2K(2), MAP2K1(2), MAP3K8(1), MAPK3(1), MKNK1(1), MKNK2(2), NFKB1(2), RAP1A(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), SOS1(5), SOS2(5), TRAF3(3)	8459294	43	31	42	12	19	1	12	4	7	0	0.541	1.000	1.000
502	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	21	FOS(2), HRAS(1), JAK2(6), JUN(2), MAP2K1(2), MAPK3(1), MPL(1), PIK3R1(10), PLCG1(3), PRKCA(3), RASA1(4), SOS1(5), STAT1(2), STAT3(2), STAT5A(2), STAT5B(1), THPO(1)	8071075	48	31	48	15	23	3	11	2	8	1	0.626	1.000	1.000
503	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(1), ARSE(1), ASAH1(2), B4GALT6(1), CERK(3), DEGS1(1), ENPP7(2), GAL3ST1(2), GALC(1), GLA(1), GLB1(4), LCT(3), NEU1(2), PPAP2B(4), SGMS1(1), SGPP1(1), SMPD1(3), SMPD2(1), SMPD4(2), SPHK1(1), SPHK2(1), SPTLC1(1), SPTLC2(2), UGCG(2)	9991567	43	30	43	23	25	4	7	1	6	0	0.944	1.000	1.000
504	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(1), ADRBK2(2), CALM1(2), CALM3(1), CALML6(1), CAMK2A(3), CAMK2B(1), CAMK2D(2), CLCA2(1), CLCA4(3), CNGA3(3), CNGA4(3), CNGB1(5), GNAL(2), PDE1C(6), PRKACA(2), PRKG2(3)	8974409	41	30	41	20	18	5	13	3	2	0	0.934	1.000	1.000
505	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	ELK1(2), FOS(2), HRAS(1), JAK1(1), JUN(2), MAP2K1(2), MAP3K1(4), MAPK3(1), MAPK8(1), PDGFRA(2), PIK3R1(10), PLCG1(3), PRKCA(3), RASA1(4), SOS1(5), STAT1(2), STAT3(2), STAT5A(2)	9546601	49	30	49	18	23	2	15	3	6	0	0.792	1.000	1.000
506	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(3), CAMK2B(1), CAMK2D(2), DAG1(3), ITPKA(1), ITPKB(1), ITPR1(8), ITPR2(5), ITPR3(2), NFAT5(5), PDE6A(1), PDE6B(1), PDE6C(2), PDE6D(2), SLC6A13(2)	10565980	39	30	39	21	22	1	11	2	3	0	0.962	1.000	1.000
507	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(3), EGFR(7), IGF1R(3), MYC(1), POLR2A(5), PRKCA(3), TEP1(8), TERF1(5), TERT(1), TNKS(2), TP53(12)	7655364	50	30	48	26	31	2	12	2	3	0	0.949	1.000	1.000
508	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(7), ATF2(2), BMP4(2), BMP5(1), BMPR1A(1), BMPR2(3), CHRD(3), CTNNB1(5), FZD1(1), MEF2C(1), NPPA(1), RFC1(2), TGFB2(1), TGFB3(2), TGFBR1(1), TGFBR2(5), WNT1(1)	10402767	39	29	37	14	19	1	7	6	6	0	0.853	1.000	1.000
509	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	20	ARHGAP5(4), DIAPH1(1), FYN(3), GSN(2), HRAS(1), ITGA1(3), ITGB1(2), MAP2K1(2), MAPK3(1), MYLK(2), PIK3R1(10), PTK2(2), PXN(2), ROCK1(3), TLN1(3)	10238062	41	29	41	14	18	2	13	2	6	0	0.758	1.000	1.000
510	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(3), CALCRL(1), CD97(2), CRHR1(2), CRHR2(2), ELTD1(2), EMR2(3), GIPR(3), GLP1R(1), GPR64(5), LPHN1(3), LPHN2(4), LPHN3(10), SCTR(1), VIPR2(1)	8057328	43	29	43	19	22	4	12	2	3	0	0.676	1.000	1.000
511	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	29	AKT1(3), CABIN1(5), CALM1(2), CALM3(1), CAMK1(2), HDAC5(2), IGF1R(3), INSR(4), MAPK7(2), MEF2A(1), MEF2B(1), MEF2C(1), MEF2D(3), NFATC1(4), NFATC2(4), PIK3R1(10), PPP3CA(1), PPP3CC(1), SYT1(2)	9400049	52	29	51	21	29	7	8	4	4	0	0.823	1.000	1.000
512	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(3), ASL(2), ASS1(2), CKB(1), CKM(1), CKMT2(2), CPS1(1), DAO(1), EPRS(7), GLUD1(2), GLUD2(1), GOT2(1), LAP3(1), NOS1(2), NOS3(6), OTC(1), P4HA2(3), PRODH(1), RARS2(5)	10565516	43	29	42	20	26	1	7	2	7	0	0.906	1.000	1.000
513	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(2), ALG13(6), ALG6(3), ALG8(3), ALG9(1), B4GALT3(1), DPAGT1(1), FUT8(3), GANAB(4), MAN1A1(1), MAN1A2(1), MAN1B1(3), MAN1C1(3), MAN2A1(3), MGAT2(1), MGAT3(3), MGAT5(2), MGAT5B(1), RFT1(1), RPN1(2), ST6GAL1(2)	12170320	47	29	46	13	25	4	10	1	7	0	0.357	1.000	1.000
514	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ACACA(5), ACACB(6), ACADM(4), ACAT1(2), ACAT2(1), ACSS1(3), ACSS2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), EHHADH(1), HIBCH(1), LDHAL6A(1), LDHAL6B(1), LDHC(3), PCCA(1), SUCLA2(1), SUCLG1(1), SUCLG2(1)	11545930	43	29	43	15	25	2	4	7	5	0	0.649	1.000	1.000
515	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	28	EGFR(7), ELK1(2), GNAS(6), GNB1(1), GNGT1(1), HRAS(1), IGF1R(3), ITGB1(2), KLK2(3), MAP2K1(2), MAPK3(1), MKNK1(1), MKNK2(2), MYC(1), NGFR(1), PDGFRA(2), PTPRR(1), RPS6KA1(1), RPS6KA5(2), SOS1(5), STAT3(2)	9416199	47	28	46	19	25	2	11	3	6	0	0.831	1.000	1.000
516	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ADC(1), AGMAT(1), ALDH18A1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), AMD1(5), AOC2(1), AOC3(3), ASL(2), ASS1(2), CPS1(1), MAOA(1), MAOB(3), NAGS(2), ODC1(2), OTC(1), SAT1(1), SMS(1), SRM(1)	8553566	38	28	38	12	23	0	7	4	4	0	0.448	1.000	1.000
517	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3D(2), CXCR3(1), ETV5(2), IFNG(1), IL12A(2), IL12B(2), IL12RB1(1), IL12RB2(2), IL18R1(2), JAK2(6), JUN(2), MAPK8(1), STAT4(4), TYK2(9)	5499326	37	28	37	11	20	4	4	1	6	2	0.561	1.000	1.000
518	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(2), IKBKB(2), IL1A(2), IL1R1(2), IL1RAP(5), IL6(1), IRAK1(3), IRAK2(1), IRAK3(2), JUN(2), MAP2K3(2), MAP3K1(4), MAPK8(1), NFKB1(2), NFKBIA(2), RELA(7), TGFB2(1), TGFB3(2), TOLLIP(1), TRAF6(1)	8676732	45	28	44	17	24	1	8	4	8	0	0.871	1.000	1.000
519	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(6), C5(3), C6(5), C7(3), IL1A(2), IL6(1), IL8(2), ITGA4(6), ITGAL(4), ITGB1(2), VCAM1(2)	7204753	36	28	36	13	18	5	9	1	3	0	0.738	1.000	1.000
520	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ACAA2(1), ACADM(4), ACADS(3), ACAT1(2), ACAT2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), AOX1(3), AUH(1), BCAT1(1), BCAT2(2), BCKDHA(1), BCKDHB(1), DBT(1), EHHADH(1), HADH(1), HIBCH(1), HMGCS1(1), HSD17B10(1), HSD17B4(10), PCCA(1)	12549184	46	27	46	13	25	3	6	6	6	0	0.482	1.000	1.000
521	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	ALOX12(2), ALOX12B(1), ALOX15B(2), ALOX5(3), CBR3(1), CYP2C18(3), CYP2C19(1), CYP2C9(3), CYP2E1(1), CYP2J2(2), CYP2U1(1), CYP4A22(2), CYP4F3(1), EPHX2(2), PLA2G12A(1), PLA2G12B(3), PLA2G2D(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PTGS2(2)	11451691	38	27	38	22	28	0	5	1	4	0	0.886	1.000	1.000
522	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	31	AKT1(3), BAD(2), CBL(1), FOS(2), HRAS(1), IRS1(2), JAK1(1), JAK3(4), MAPK3(1), MYC(1), NMI(1), PIK3R1(10), RPS6KB1(1), SOCS3(6), SOS1(5), STAT5A(2), STAT5B(1), SYK(1)	9592032	45	27	44	15	24	3	11	2	5	0	0.621	1.000	1.000
523	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	27	CALM1(2), CALM3(1), GNAQ(2), HRAS(1), JUN(2), MAP2K1(2), MAP2K3(2), MAP3K1(4), MAPK3(1), MAPK8(1), PAK1(1), PLCG1(3), PRKCA(3), PTK2B(3), RAC1(1), SOS1(5), SYT1(2)	8078767	36	27	36	14	20	2	9	3	2	0	0.809	1.000	1.000
524	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), ACTN1(1), ACTN2(2), CAPN1(5), CAPNS1(1), ITGA1(3), ITGB1(2), ITGB3(3), PTK2(2), PXN(2), RAC1(1), SPTAN1(11), TLN1(3)	8475279	37	27	36	15	16	2	10	1	8	0	0.809	1.000	1.000
525	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(2), CHUK(2), IFNG(1), IKBKB(2), JUN(2), MAP3K1(4), MAP3K5(11), MAP4K5(4), MAPK8(1), NFKB1(2), NFKBIA(2), RELA(7), TRAF2(1)	5755104	41	26	41	10	25	1	7	3	5	0	0.455	1.000	1.000
526	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(1), AZIN1(3), CBX3(1), CRY1(1), CRY2(1), DNAJA1(1), ETV6(2), GFRA1(3), HERPUD1(1), HSPA8(5), IDI1(1), KLF9(1), MYF6(4), NCKAP1(3), NCOA4(1), NR1D2(2), PER1(3), PER2(1), PURA(1), SF3A3(1), SUMO3(2), UGP2(2), ZFR(1)	10593418	42	26	42	16	26	1	9	3	3	0	0.896	1.000	1.000
527	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(3), ACO1(2), FH(1), IDH3A(2), IDH3B(1), IDH3G(1), MDH1(1), MDH2(1), OGDH(4), OGDHL(3), PC(1), PCK2(1), SDHA(4), SDHB(1), SDHD(1), SUCLA2(1), SUCLG1(1), SUCLG2(1)	8784451	30	26	30	10	17	0	7	0	6	0	0.492	1.000	1.000
528	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	26	ALDH1A3(2), ALDH3A1(1), AOC2(1), AOC3(3), DDC(2), EPX(4), ESCO1(1), ESCO2(1), GOT2(1), HPD(2), LPO(2), MAOA(1), MAOB(3), MPO(2), NAT6(1), PNPLA3(1), SH3GLB1(2), TAT(3), TPO(6)	9840841	39	26	39	13	23	1	10	3	2	0	0.559	1.000	1.000
529	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	22	POLR1A(7), POLR1B(3), POLR1C(3), POLR2A(5), POLR2B(3), POLR2C(1), POLR2F(1), POLR2H(1), POLR2L(1), POLR3A(1), POLR3B(3), POLR3G(2)	6751317	31	25	31	15	23	1	4	2	1	0	0.944	1.000	1.000
530	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	23	ACTA1(1), CAPN1(5), CAPNS1(1), CXCR3(1), EGF(1), EGFR(7), HRAS(1), ITGA1(3), ITGB1(2), MAPK3(1), MYLK(2), PRKAR2A(1), PTK2(2), PXN(2), TLN1(3)	9560718	33	25	33	18	15	2	12	1	3	0	0.963	1.000	1.000
531	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	19	AKT1(3), EIF4A1(3), EIF4A2(3), EIF4B(3), EIF4G1(5), EIF4G3(4), MKNK1(1), PDK2(1), PDPK1(2), PIK3R1(10), RPS6KB1(1), TSC1(2), TSC2(6)	7257157	44	25	43	16	24	5	8	1	6	0	0.868	1.000	1.000
532	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(11), BMPR1B(2), DAZL(2), DMC1(1), EGR1(3), FSHR(2), LHCGR(1), MLH1(1), MSH5(2), NCOR1(5), NRIP1(4), PGR(2), PRLR(1), SMPD1(3), VDR(1), ZP2(4)	9917525	45	25	44	15	26	3	6	3	7	0	0.760	1.000	1.000
533	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(1), EGF(1), EGFR(7), HRAS(1), MAP2K1(2), MAPK3(1), PTPRB(5), RASA1(4), SOS1(5), SPRY1(2), SPRY3(2), SPRY4(2)	7089740	33	25	33	10	13	2	12	2	4	0	0.631	1.000	1.000
534	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(7), BTRC(1), CCND1(1), CREBBP(15), CSNK1D(2), CTBP1(1), CTNNB1(5), FZD1(1), MYC(1), PPARD(2), WIF1(1), WNT1(1)	8543639	38	25	35	12	20	1	8	3	5	1	0.723	1.000	1.000
535	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(2), DDX20(3), E2F4(1), ETS2(1), FOS(2), HDAC5(2), HRAS(1), JUN(2), NCOR2(6), RBL1(3), RBL2(2), SIN3A(3), SIN3B(2)	7937218	30	24	30	10	15	1	6	3	5	0	0.639	1.000	1.000
536	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(1), ALDOA(3), ALDOB(1), ALDOC(1), FPGT(2), FUK(2), GMDS(1), GMPPA(1), HK1(2), HK2(4), HK3(1), HSD3B7(1), KHK(2), MTMR1(3), MTMR2(1), MTMR6(1), PFKFB1(1), PFKFB2(1), PGM2(1), PHPT1(1), PMM2(1), RDH13(1)	11080115	33	24	33	14	17	2	9	1	4	0	0.694	1.000	1.000
537	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(2), GLB1(4), HEXB(2), LCT(3), SLC33A1(3), ST3GAL1(2), ST3GAL2(1), ST3GAL5(2), ST6GALNAC3(3), ST6GALNAC5(1), ST6GALNAC6(3), ST8SIA1(2), ST8SIA5(1)	4729652	29	24	29	12	11	2	11	1	4	0	0.650	1.000	1.000
538	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	ELK1(2), FOS(2), HRAS(1), IL6(1), IL6R(3), IL6ST(2), JAK1(1), JAK2(6), JAK3(4), JUN(2), MAP2K1(2), MAPK3(1), SOS1(5), STAT3(2)	6942295	34	24	34	10	17	2	8	1	5	1	0.506	1.000	1.000
539	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(3), AP2A1(3), AP2M1(2), BAD(2), BTK(4), EEA1(3), GRASP(1), GSK3A(3), PDPK1(2), PLCG1(3), PRKCE(1), PRKCZ(1), RAB5A(1), RAC1(1), RPS6KB1(1), VAV2(3)	7468091	34	24	33	17	16	1	10	3	4	0	0.901	1.000	1.000
540	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	20	AKT1(3), BAD(2), CASP9(1), CDC42(1), CHUK(2), ELK1(2), H2AFX(1), HRAS(1), MAP2K1(2), MAPK3(1), NFKB1(2), PIK3R1(10), RAC1(1), RALA(1), RALBP1(3), RALGDS(2), RELA(7), RHOA(2)	5081548	44	24	43	12	26	3	8	2	5	0	0.431	1.000	1.000
541	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	21	BTK(4), DLG4(2), EPHB2(3), F2RL2(1), F2RL3(2), JUN(2), MAPK7(2), MAPK8(1), MYEF2(1), PLD1(3), PTK2(2), RASAL1(1), VAV1(2)	7838927	26	24	26	11	9	1	9	3	4	0	0.800	1.000	1.000
542	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	CASP2(2), CHUK(2), IKBKB(2), JUN(2), MAP2K3(2), MAP3K1(4), MAP4K2(2), MAPK8(1), NFKB1(2), NFKBIA(2), RELA(7), RIPK1(2), TANK(3), TNFRSF1A(4), TRAF2(1)	6911551	38	24	38	18	23	2	6	2	5	0	0.957	1.000	1.000
543	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(3), CARS(1), EPRS(7), FARS2(1), GARS(1), LARS(3), LARS2(1), MARS(2), MARS2(2), QARS(2), SARS(1), TARS(2), WARS(1), WARS2(1), YARS(2)	9274141	30	23	30	12	22	0	4	2	2	0	0.816	1.000	1.000
544	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(3), AGT(2), EDN1(1), EDNRA(1), EDNRB(2), EGF(1), EGFR(7), FOS(2), HRAS(1), JUN(2), MYC(1), NFKB1(2), PLCG1(3), PRKCA(3), RELA(7)	5930869	38	23	38	12	21	1	10	1	5	0	0.481	1.000	1.000
545	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	66	RPL11(1), RPL13A(2), RPL18(1), RPL27(1), RPL28(3), RPL29(2), RPL3(2), RPL31(1), RPL35(1), RPL6(2), RPL8(1), RPL9(1), RPS10(1), RPS13(2), RPS2(1), RPS21(1), RPS23(1), RPS24(1), RPS25(1), RPS3A(1), RPS5(1), RPS7(1), RPS9(1)	6572674	30	23	30	12	21	1	3	0	5	0	0.591	1.000	1.000
546	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	20	ELK1(2), FOS(2), HRAS(1), INSR(4), IRS1(2), JUN(2), MAP2K1(2), MAPK3(1), MAPK8(1), PIK3R1(10), RASA1(4), SOS1(5)	6762217	36	23	36	10	15	3	11	2	5	0	0.470	1.000	1.000
547	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(2), FADD(1), IKBKB(2), IL1A(2), IL1R1(2), IRAK1(3), MAP3K1(4), NFKB1(2), NFKBIA(2), RELA(7), RIPK1(2), TLR4(2), TNFAIP3(2), TNFRSF1A(4), TNFRSF1B(2), TRAF6(1)	6912248	40	23	40	12	20	3	6	3	8	0	0.639	1.000	1.000
548	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(2), ALDH3A1(1), AOC2(1), AOC3(3), DDC(2), EPX(4), GOT2(1), HPD(2), LPO(2), MAOA(1), MAOB(3), MPO(2), PRDX1(1), TAT(3), TPO(6)	6411621	34	23	34	13	20	1	9	2	2	0	0.511	1.000	1.000
549	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	26	BAG4(1), BIRC2(2), BIRC3(1), CASP3(1), FADD(1), JUN(2), MAP3K3(1), NFKB1(2), NFKB2(1), NFKBIA(2), NFKBIE(2), NR2C2(1), RALBP1(3), RIPK1(2), TNFAIP3(2), TNFRSF1A(4), TNFRSF1B(2), TRAF2(1)	7343639	31	23	31	14	16	4	6	0	5	0	0.927	1.000	1.000
550	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	18	CHUK(2), DUSP1(1), IKBKAP(3), IKBKB(2), MAP3K1(4), NFKB1(2), NFKBIA(2), RELA(7), RIPK1(2), TANK(3), TNFAIP3(2), TNFRSF1B(2), TRAF1(1), TRAF2(1), TRAF3(3)	6586389	37	23	36	12	23	2	8	2	2	0	0.639	1.000	1.000
551	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(3), ADSS(1), AGXT(1), ASL(2), ASPA(1), CAD(8), CRAT(1), DDO(1), GAD1(4), GOT2(1), GPT2(2), PC(1)	7679194	26	22	26	12	12	0	11	1	2	0	0.845	1.000	1.000
552	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(1), ARSE(1), ASAH1(2), GAL3ST1(2), GALC(1), GLA(1), GLB1(4), LCT(3), NEU1(2), PPAP2B(4), SMPD1(3), SMPD2(1), SPTLC1(1), SPTLC2(2), UGCG(2)	6678001	30	22	30	12	16	3	5	1	5	0	0.750	1.000	1.000
553	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT2(1), AGPAT4(1), AGPAT6(1), AGPS(2), CHPT1(1), ENPP2(8), ENPP6(1), PAFAH1B1(2), PAFAH1B2(1), PLA2G12A(1), PLA2G12B(3), PLA2G2D(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLD1(3), PPAP2B(4)	6765936	36	22	36	13	20	1	4	6	5	0	0.651	1.000	1.000
554	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX5(3), CYP1A2(1), CYP2C18(3), CYP2C19(1), CYP2C9(3), CYP2E1(1), CYP2J2(2), CYP3A43(2), CYP3A5(2), CYP3A7(1), HSD3B7(1), PLA2G12A(1), PLA2G12B(3), PLA2G2D(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), RDH13(1)	6999910	32	22	32	13	22	0	7	1	2	0	0.573	1.000	1.000
555	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(4), AKT1(3), BAD(2), CSF2RB(2), IGF1R(3), IL3RA(2), KIT(3), KITLG(1), PIK3R1(10), PRKAR2A(1)	5704015	31	21	30	16	17	2	6	2	4	0	0.902	1.000	1.000
556	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ACADM(4), ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), AOC2(1), AOC3(3), DPYD(3), DPYS(1), EHHADH(1), GAD1(4), SDS(1), SMS(1)	8348369	32	21	32	13	17	1	4	5	5	0	0.780	1.000	1.000
557	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CARM1(1), CBS(1), HEMK1(1), LCMT1(4), LCMT2(1), MARS(2), MARS2(2), MAT1A(1), METTL2B(1), PAPSS1(1), PAPSS2(2), PRMT2(1), PRMT5(1), PRMT6(1), PRMT7(3), SCLY(1), SEPHS1(1), SEPHS2(2)	7201356	27	21	27	15	16	1	7	1	2	0	0.930	1.000	1.000
558	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	19	ELK1(2), FOS(2), HRAS(1), IGF1R(3), IRS1(2), JUN(2), MAP2K1(2), MAPK3(1), MAPK8(1), PIK3R1(10), RASA1(4), SOS1(5)	6536446	35	21	35	16	14	3	11	2	5	0	0.941	1.000	1.000
559	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(2), AP2A1(3), AP2M1(2), BIN1(2), CALM1(2), CALM3(1), DNM1(1), EPS15(5), PICALM(2), PPP3CA(1), PPP3CC(1), SYNJ1(2), SYNJ2(1), SYT1(2)	6597059	27	21	27	11	17	2	2	3	3	0	0.843	1.000	1.000
560	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ACACA(5), ACADM(4), ACAT1(2), ACAT2(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), EHHADH(1), LDHC(3), PCCA(1), SDS(1), SUCLA2(1), SUCLG1(1), SUCLG2(1)	9639174	34	21	34	17	19	2	3	5	5	0	0.961	1.000	1.000
561	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(2), CALM3(1), CHUK(2), EGR3(1), GNAQ(2), MAP3K1(4), MYC(1), NFATC1(4), NFATC2(4), NFKB1(2), NFKBIA(2), PLCG1(3), PPP3CA(1), PPP3CC(1), PRKAR2A(1), RELA(7), SYT1(2), VIP(2), VIPR2(1)	7884657	43	21	43	15	27	5	6	3	2	0	0.729	1.000	1.000
562	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	AGT(2), AGTR1(1), COL4A1(4), COL4A2(4), COL4A3(4), COL4A4(2), COL4A5(3), COL4A6(4), REN(1)	7607127	25	20	25	16	13	3	6	1	2	0	0.999	1.000	1.000
563	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	GALNS(2), GLB1(4), GNS(3), GUSB(4), HEXB(2), IDS(8), LCT(3), NAGLU(1)	4204801	27	20	27	10	16	2	5	2	2	0	0.607	1.000	1.000
564	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	ELK1(2), FOS(2), HRAS(1), JAK1(1), JAK3(4), JUN(2), MAP2K1(2), MAPK3(1), MAPK8(1), SOS1(5), STAT5A(2), STAT5B(1), SYK(1)	6852584	25	20	25	11	10	1	11	1	2	0	0.814	1.000	1.000
565	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	17	CABIN1(5), CALM1(2), CALM3(1), CAPNS1(1), MEF2D(3), NFATC1(4), NFATC2(4), PPP3CA(1), PPP3CC(1), PRKCA(3), SYT1(2)	5484863	27	20	27	10	20	3	2	0	2	0	0.738	1.000	1.000
566	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA2(1), ANXA3(2), ANXA5(1), CYP11A1(3), EDN1(1), EDNRA(1), EDNRB(2), HPGD(3), HSD11B2(1), PLA2G4A(3), PRL(3), PTGDR(2), PTGER4(2), PTGFR(1), PTGS2(2)	5938997	28	20	28	18	14	3	4	4	3	0	0.982	1.000	1.000
567	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	19	AKT1(3), CCND1(1), CDK2(1), CDKN1A(1), HRAS(1), MAPK3(1), NFKB1(2), NFKBIA(2), PAK1(1), PIK3R1(10), RAC1(1), RELA(7), TFDP1(2)	4560302	33	20	32	12	17	3	7	3	3	0	0.765	1.000	1.000
568	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(1), GTF2A1(1), GTF2E1(1), HDAC3(3), NCOA1(4), NCOA2(2), NCOA3(1), NCOR2(6), POLR2A(5), RXRA(1), TBP(1)	7416999	26	20	25	11	13	0	9	1	2	1	0.875	1.000	1.000
569	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(2), GPLD1(2), PGAP1(4), PIGA(2), PIGG(2), PIGH(1), PIGK(2), PIGM(1), PIGN(1), PIGO(2), PIGQ(2), PIGU(2), PIGX(1)	7211021	24	19	24	10	14	1	7	1	1	0	0.656	1.000	1.000
570	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), BCAT2(2), COASY(1), DPYD(3), DPYS(1), ENPP1(2), ENPP3(5), PANK1(2), PANK3(2), PANK4(1), PPCDC(1)	4995785	21	19	21	13	10	0	3	4	4	0	0.982	1.000	1.000
571	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	11	AKT1(3), CAT(2), GHR(6), HRAS(1), IGF1R(3), PIK3R1(10)	3169622	25	19	24	10	11	2	7	2	3	0	0.795	1.000	1.000
572	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(2), CALM3(1), DLG4(2), GRIN2A(4), GRIN2B(3), GRIN2D(3), NOS1(2), PPP3CA(1), PPP3CC(1), PRKAR2A(1), PRKCA(3), SYT1(2)	7527471	25	19	25	18	16	1	3	3	2	0	0.989	1.000	1.000
573	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	ALOX12(2), ALOX5(3), CBR3(1), CYP4F3(1), EPX(4), LPO(2), MPO(2), PLA2G4A(3), PLA2G6(2), PRDX1(1), PTGS2(2), TPO(6)	8205937	29	19	29	24	17	1	8	1	2	0	0.996	1.000	1.000
574	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(5), APOA4(1), CETP(1), CYP7A1(2), DGAT1(2), HMGCR(1), LCAT(3), LDLR(1), LIPC(2), LPL(2), LRP1(5)	7935986	25	19	25	16	10	1	8	1	5	0	0.969	1.000	1.000
575	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(1), ACADM(4), ACADS(3), ACAT1(2), ACAT2(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), AOX1(3), BCAT1(1), BCKDHA(1), BCKDHB(1), EHHADH(1), PCCA(1), SDS(1)	10483315	33	19	33	15	16	2	6	4	5	0	0.928	1.000	1.000
576	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(4), COL4A2(4), COL4A3(4), COL4A4(2), COL4A5(3), COL4A6(4), P4HB(2), SLC2A1(1), SLC2A3(1)	7612062	25	19	25	17	14	2	6	1	2	0	0.999	1.000	1.000
577	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	17	AKT1(3), EIF2B5(1), EIF2S1(3), EIF2S2(2), IGF1R(3), INPPL1(4), PDK2(1), PDPK1(2), PIK3R1(10), RPS6KB1(1)	4844541	30	18	29	10	17	3	5	2	3	0	0.674	1.000	1.000
578	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	13	AKT1(3), BAD(2), HRAS(1), IGF1R(3), IRS1(2), MAP2K1(2), MAPK3(1), PIK3R1(10), SOS1(5)	4640590	29	18	28	12	14	3	7	2	3	0	0.854	1.000	1.000
579	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(3), JAK1(1), PTPRU(3), REG1A(2), STAT1(2), STAT2(3), TYK2(9)	3629750	23	18	23	12	17	0	2	3	0	1	0.850	1.000	1.000
580	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5R1(1), CSNK1D(2), GRM1(3), PLCB1(10), PPP3CA(1), PRKAR2A(1)	4641547	18	17	18	10	10	1	5	1	1	0	0.907	1.000	1.000
581	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1R(1), C1S(1), C2(1), C3(6), C5(3), C6(5), C7(3), C9(1), MASP1(1), MASP2(2)	6110623	24	17	24	10	13	3	5	1	2	0	0.852	1.000	1.000
582	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(3), ALDOB(1), ALDOC(1), G6PD(1), GPI(3), H6PD(2), PGD(2), PGM3(1), PRPS2(2), TKT(1), TKTL1(2), TKTL2(1)	7007259	20	17	20	11	9	2	7	1	1	0	0.874	1.000	1.000
583	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	37	ANPEP(1), G6PD(1), GCLM(1), GSR(1), GSTA2(2), GSTA3(2), GSTA4(1), GSTA5(1), GSTM2(1), GSTM4(1), GSTT1(2), GSTT2(1), GSTZ1(1), MGST3(1)	6585273	17	17	17	11	8	1	5	0	3	0	0.921	1.000	1.000
584	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	CAT(2), EPX(4), LPO(2), MPO(2), MTHFR(4), SHMT1(2), SHMT2(1), TPO(6)	3365087	23	17	23	13	12	1	7	1	2	0	0.921	1.000	1.000
585	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AOC2(1), AOC3(3), CES1(3), DDHD1(2), ESCO1(1), ESCO2(1), LIPA(1), NAT6(1), PLA1A(2), PNPLA3(1), PPME1(2), SH3GLB1(2)	7284045	20	17	20	6	13	1	3	3	0	0	0.626	1.000	1.000
586	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), COASY(1), DPYD(3), DPYS(1), ENPP1(2), ENPP3(5), PANK1(2), PANK3(2), PANK4(1)	3984650	18	17	18	11	7	0	3	4	4	0	0.983	1.000	1.000
587	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(3), POLR2A(5), POLR2B(3), POLR2C(1), POLR2F(1), POLR2H(1), POLR2L(1), POLRMT(5)	3820856	20	17	20	11	13	1	4	2	0	0	0.944	1.000	1.000
588	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(3), ALDOB(1), ALDOC(1), GOT2(1), GPT2(2), MDH1(1), MDH2(1), ME1(1), PGK1(1), PGK2(1), PKLR(3), TKT(1), TKTL1(2), TKTL2(1)	5827393	20	16	20	11	9	2	7	0	2	0	0.896	1.000	1.000
589	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(3), IFNAR2(2), JAK1(1), STAT1(2), STAT2(3), TYK2(9)	3150210	20	15	20	10	16	0	1	2	0	1	0.842	1.000	1.000
590	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	CAT(2), EPX(4), LPO(2), MPO(2), PRDX1(1), SHMT1(2), SHMT2(1), TPO(6)	3457636	20	15	20	14	12	1	6	0	1	0	0.966	1.000	1.000
591	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(1), GALNT3(1), GALNT4(2), GALNT6(1), GALNT7(2), GALNT9(4), ST3GAL1(2), ST3GAL2(1), WBSCR17(5)	4265542	19	15	19	11	10	1	5	2	1	0	0.941	1.000	1.000
592	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(4), GLI2(6), GLI3(4), PRKAR2A(1), SMO(1), SUFU(2)	4609486	18	15	18	7	10	1	5	2	0	0	0.703	1.000	1.000
593	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(1), B3GAT3(1), B4GALT7(1), CHPF(1), CHST11(2), CHST12(2), CHST14(1), CHST3(2), CHSY1(1), DSE(2), UST(1), XYLT2(1)	3630361	16	14	16	12	8	0	6	2	0	0	0.965	1.000	1.000
594	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	CA14(3), CA2(1), CA4(1), CA6(2), CA7(1), CA8(1), CPS1(1), GLS2(2), GLUD1(2), GLUD2(1), GLUL(1), HAL(1)	6126566	17	14	17	10	10	0	2	3	2	0	0.960	1.000	1.000
595	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(1), CD44(2), IL6R(3), SELL(1), SPN(1), TGFB2(1), TNFRSF1A(4), TNFRSF1B(2), TNFRSF8(3)	3819254	18	14	18	10	10	2	1	0	5	0	0.936	1.000	1.000
596	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(1), ASL(2), CKB(1), CKM(1), CKMT2(2), CPS1(1), GLUD1(2), NAGS(2), ODC1(2), OTC(1), SMS(1)	5184008	16	14	16	12	10	0	1	1	4	0	0.988	1.000	1.000
597	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(1), CNR2(1), DNMT1(3), MTNR1A(1), MTNR1B(2), PTAFR(1), PTGDR(2), PTGER4(2), PTGFR(1), TBXA2R(1)	3124852	15	13	15	14	5	2	4	3	1	0	0.988	1.000	1.000
598	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(4), LPO(2), MPO(2), PRDX1(1), TPO(6), TYR(2)	2824320	17	13	17	13	10	1	6	0	0	0	0.981	1.000	1.000
599	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(2), MAPK8(1), NFKB1(2), RELA(7), TNFRSF13B(1), TNFSF13B(1), TRAF2(1), TRAF3(3), TRAF5(1), TRAF6(1)	4251709	20	13	19	11	13	1	3	1	2	0	0.971	1.000	1.000
600	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(4), LPO(2), MPO(2), TPO(6)	2437759	14	11	14	9	8	1	5	0	0	0	0.920	1.000	1.000
601	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CBS(1), MARS(2), MARS2(2), MAT1A(1), PAPSS1(1), PAPSS2(2), SCLY(1), SEPHS1(1)	3617396	11	10	11	9	7	0	3	1	0	0	0.972	1.000	1.000
602	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(2), ALOX15B(2), ALOX5(3), PLA2G6(2), PTGS2(2)	4535836	11	9	11	12	7	0	2	0	2	0	0.992	1.000	1.000
603	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(2), KHK(2), LCT(3), PYGM(1)	3928055	8	8	8	7	3	0	3	2	0	0	0.970	1.000	1.000
604	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	11	CDK2(1), CUL1(4), RBX1(1), TFDP1(2)	2003986	8	7	8	6	6	1	0	1	0	0	0.964	1.000	1.000
605	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(1), CKM(1), LDHC(3), NCL(3)	2656141	8	7	8	4	5	0	1	2	0	0	0.852	1.000	1.000
606	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(1), CRY1(1), CRY2(1), PER1(3)	2458205	6	6	6	5	5	0	1	0	0	0	0.977	1.000	1.000
607	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	6	CDK2(1), CUL1(4), TFDP1(2)	1455611	7	6	7	5	5	1	0	1	0	0	0.950	1.000	1.000
608	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(2), NR3C1(4), PPARG(1), RXRA(1)	1586365	8	6	8	4	6	0	2	0	0	0	0.815	1.000	1.000
609	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(1), GOT2(1), LDHC(3)	1932330	5	5	5	4	4	0	0	1	0	0	0.946	1.000	1.000
610	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS2(2), GLUD1(2), GLUD2(1)	1301497	5	5	5	5	5	0	0	0	0	0	0.984	1.000	1.000
611	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ASL(2), CPS1(1), GLUD1(2)	2258638	5	5	5	5	3	0	1	1	0	0	0.983	1.000	1.000
612	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(2), ALDH1A2(2)	1127813	4	4	4	3	3	0	1	0	0	0	0.920	1.000	1.000
613	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOA(3), ALDOB(1), ALDOC(1)	1121872	5	4	5	3	3	1	1	0	0	0	0.840	1.000	1.000
614	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASS(2)	1379470	2	2	2	2	2	0	0	0	0	0	0.971	1.000	1.000
615	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2		466418	0	0	0	2	0	0	0	0	0	0	1.000	1.000	1.000
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		147052	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
