		Clinical Features	CN_CNMF		METHLYATION_CNMF		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL		MIRSEQ_MATURE_CNMF		MIRSEQ_MATURE_CHIERARCHICAL	
	nCNV (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
1p gain	37 (20%)	147	0.64824	1	0.22434	1	0.67298	1	0.69184	1	1	1	0.88368	1	0.45273	1	0.96515	1
1q gain	63 (34%)	121	0.061829	1	0.20695	1	0.23976	1	0.11311	1	0.38333	1	0.48842	1	0.50703	1	0.62813	1
2p gain	61 (33%)	123	0.01205	1	0.03142	1	0.14737	1	0.41625	1	0.03704	1	0.34202	1	0.00283	1	0.50673	1
2q gain	46 (25%)	138	0.26654	1	0.070069	1	0.50211	1	0.17765	1	0.48559	1	0.76777	1	0.2565	1	0.8862	1
3p gain	31 (17%)	153	0.30494	1	0.44708	1	0.2743	1	0.93454	1	0.77926	1	0.60921	1	0.86207	1	0.61561	1
3q gain	77 (42%)	107	9.9999e-06	0.0064	0.02034	1	0.28569	1	0.03006	1	0.30818	1	0.24077	1	0.16668	1	0.41084	1
4p gain	19 (10%)	165	0.52867	1	0.85677	1	0.11288	1	1	1	1	1	0.95854	1	0.97993	1	1	1
4q gain	18 (10%)	166	0.086929	1	0.32734	1	0.00261	1	0.36664	1	0.30599	1	0.54549	1	0.55821	1	0.49095	1
5p gain	76 (41%)	108	4e-05	0.0245	0.02734	1	0.092049	1	0.1579	1	0.01342	1	0.03327	1	0.050109	1	0.01641	1
5q gain	20 (11%)	164	0.40932	1	0.779	1	0.46926	1	0.60363	1	0.69876	1	0.98645	1	0.7519	1	0.79299	1
6p gain	38 (21%)	146	0.24051	1	0.36878	1	0.69966	1	0.38814	1	0.25145	1	0.1031	1	0.11466	1	0.0303	1
6q gain	33 (18%)	151	0.23502	1	0.32796	1	0.70578	1	0.2475	1	0.37656	1	0.28589	1	0.14902	1	0.082879	1
7p gain	110 (60%)	74	0.34769	1	0.23454	1	0.11498	1	0.02727	1	0.074829	1	0.20755	1	0.55518	1	0.11041	1
7q gain	89 (48%)	95	0.66605	1	0.28931	1	0.69702	1	0.02312	1	0.42326	1	0.74542	1	0.8362	1	0.12371	1
8p gain	68 (37%)	116	0.317	1	0.537	1	0.77326	1	0.62474	1	0.37292	1	0.83353	1	0.55977	1	0.7374	1
8q gain	101 (55%)	83	0.46613	1	0.28598	1	0.40574	1	0.4058	1	0.29245	1	0.7259	1	0.91253	1	0.97603	1
9p gain	16 (9%)	168	0.79928	1	0.48158	1	0.45143	1	0.79496	1	0.56443	1	0.1839	1	0.58718	1	0.46776	1
9q gain	33 (18%)	151	0.39393	1	0.25697	1	0.3349	1	0.94223	1	0.38425	1	0.02902	1	0.67326	1	0.079799	1
10p gain	40 (22%)	144	0.0363	1	0.02737	1	0.20108	1	0.30985	1	0.119	1	0.21806	1	0.055579	1	0.075349	1
10q gain	30 (16%)	154	0.01502	1	0.0342	1	0.15033	1	0.23167	1	0.080399	1	0.070119	1	0.051809	1	0.02245	1
11p gain	39 (21%)	145	0.64587	1	0.91653	1	0.1494	1	0.67714	1	0.34492	1	0.31791	1	0.87504	1	0.48087	1
11q gain	29 (16%)	155	0.28803	1	0.31567	1	0.10542	1	0.02284	1	0.04767	1	0.17412	1	0.081579	1	0.077229	1
12p gain	58 (32%)	126	0.02263	1	0.00385	1	0.0085699	1	0.0055499	1	0.0059199	1	0.00283	1	0.0033	1	0.0093799	1
12q gain	38 (21%)	146	0.17426	1	0.32135	1	0.42693	1	0.2801	1	0.39308	1	0.45032	1	0.26751	1	0.25825	1
13q gain	43 (23%)	141	0.00248	1	9.9999e-06	0.0064	0.00112	0.637	9.9999e-06	0.0064	9.9999e-06	0.0064	5e-05	0.0305	0.00018	0.107	9.9999e-06	0.0064
14q gain	48 (26%)	136	0.03512	1	0.084039	1	0.13906	1	0.057729	1	0.0385	1	0.035	1	0.13791	1	0.052579	1
15q gain	30 (16%)	154	0.38948	1	0.28038	1	0.35037	1	0.03405	1	0.45361	1	0.37479	1	0.3192	1	0.36542	1
16p gain	41 (22%)	143	0.00378	1	0.098069	1	0.01952	1	0.00451	1	0.02568	1	0.03453	1	0.082889	1	0.056649	1
16q gain	38 (21%)	146	0.00081999	0.471	0.02723	1	0.0090499	1	0.0032	1	0.0123	1	0.0061899	1	0.00289	1	0.0067699	1
17p gain	33 (18%)	151	0.050659	1	0.0314	1	0.30237	1	0.24303	1	0.36595	1	0.45118	1	0.54273	1	0.55206	1
17q gain	45 (24%)	139	0.14014	1	0.2061	1	0.36958	1	0.41055	1	0.85417	1	0.93791	1	0.99218	1	0.6368	1
18p gain	50 (27%)	134	0.061729	1	0.37705	1	0.64412	1	0.33303	1	0.0228	1	0.87282	1	0.93679	1	0.8117	1
18q gain	26 (14%)	158	0.73768	1	0.81533	1	0.97213	1	0.77188	1	0.39809	1	0.30294	1	0.38219	1	0.22683	1
19p gain	28 (15%)	156	0.42979	1	0.28225	1	0.26278	1	0.62028	1	0.3813	1	0.9055	1	0.53662	1	0.49725	1
19q gain	38 (21%)	146	0.10119	1	0.13956	1	0.17793	1	0.10078	1	0.04425	1	0.35313	1	0.39832	1	0.11111	1
20p gain	108 (59%)	76	0.00464	1	0.058159	1	0.18163	1	0.5322	1	0.099129	1	0.2626	1	0.38535	1	0.057729	1
20q gain	115 (62%)	69	5e-05	0.0305	0.00031	0.183	0.04519	1	0.081299	1	4e-04	0.234	0.00064999	0.375	0.0058499	1	4e-05	0.0245
21q gain	18 (10%)	166	1	1	0.56448	1	0.02911	1	0.29721	1	0.21264	1	0.42646	1	0.3875	1	0.22938	1
22q gain	31 (17%)	153	2e-05	0.0125	2e-05	0.0125	2e-04	0.119	0.00016	0.0957	2e-05	0.0125	3e-05	0.0185	9.9999e-06	0.0064	2e-05	0.0125
xq gain	36 (20%)	148	0.063129	1	0.03753	1	0.22148	1	0.065809	1	0.01182	1	0.01939	1	0.064139	1	0.076299	1
1p loss	38 (21%)	146	0.0090399	1	0.0232	1	0.00273	1	0.23363	1	0.02046	1	0.03205	1	0.0096099	1	0.04396	1
1q loss	22 (12%)	162	0.03862	1	0.23136	1	0.11434	1	0.17497	1	0.074469	1	0.11957	1	0.02354	1	0.12658	1
2p loss	11 (6%)	173	0.85462	1	0.13434	1	0.088499	1	0.81893	1	0.38067	1	0.00178	1	0.83254	1	0.37301	1
2q loss	18 (10%)	166	0.35584	1	0.03193	1	0.27187	1	0.32183	1	0.064339	1	0.0070499	1	0.28241	1	0.087809	1
3p loss	93 (51%)	91	2e-05	0.0125	6.9999e-05	0.0424	0.00254	1	0.00302	1	9.9999e-06	0.0064	9.9999e-06	0.0064	0.00117	0.663	9.9999e-06	0.0064
3q loss	33 (18%)	151	0.85698	1	0.66951	1	0.31174	1	0.50985	1	0.65261	1	0.91267	1	0.66268	1	0.8906	1
4p loss	105 (57%)	79	0.00059999	0.347	0.076249	1	0.01937	1	0.15283	1	0.01773	1	0.28549	1	0.18422	1	0.41	1
4q loss	87 (47%)	97	0.00043	0.251	0.04607	1	0.00372	1	0.41756	1	0.0391	1	0.2209	1	0.1216	1	0.085749	1
5p loss	46 (25%)	138	0.00028	0.165	9.9999e-06	0.0064	0.0051299	1	0.03566	1	7.9999e-05	0.0483	2e-05	0.0125	0.00026	0.154	4e-05	0.0245
5q loss	86 (47%)	98	0.01943	1	0.0089699	1	0.092109	1	0.68133	1	0.02015	1	0.11342	1	0.21067	1	0.092499	1
6p loss	39 (21%)	145	0.33903	1	0.62108	1	0.076089	1	0.66677	1	0.36935	1	0.36596	1	0.8607	1	0.46213	1
6q loss	39 (21%)	145	0.33436	1	0.66181	1	0.27314	1	0.45606	1	0.48822	1	0.67972	1	0.83072	1	0.27477	1
7p loss	13 (7%)	171	0.81743	1	0.5545	1	0.0084299	1	0.22137	1	0.57773	1	0.58619	1	0.30067	1	0.6488	1
7q loss	22 (12%)	162	0.17324	1	0.33683	1	0.04855	1	0.88462	1	0.58502	1	0.85831	1	0.22725	1	0.80407	1
8p loss	63 (34%)	121	0.00468	1	0.46321	1	0.88947	1	0.70983	1	0.30893	1	0.5944	1	0.38705	1	0.30592	1
8q loss	23 (12%)	161	0.78112	1	1	1	0.98101	1	0.45657	1	0.82389	1	0.25823	1	0.71332	1	1	1
9p loss	101 (55%)	83	0.089019	1	0.11274	1	0.051859	1	0.17551	1	0.52909	1	0.56882	1	0.7848	1	0.54309	1
9q loss	65 (35%)	119	0.063309	1	0.17793	1	0.83753	1	0.44554	1	0.6475	1	0.23029	1	0.068569	1	0.79533	1
10p loss	50 (27%)	134	0.00193	1	0.00446	1	0.059869	1	0.11231	1	0.00211	1	0.0081099	1	0.01248	1	0.00239	1
10q loss	49 (27%)	135	6.9999e-05	0.0424	0.00103	0.588	0.096009	1	0.02777	1	0.00161	0.91	0.0023	1	0.0169	1	0.00173	0.974
11p loss	52 (28%)	132	0.10049	1	0.22777	1	0.76006	1	0.40504	1	0.9012	1	0.65136	1	0.82214	1	0.76987	1
11q loss	58 (32%)	126	0.00052999	0.308	0.04269	1	0.36151	1	0.059119	1	0.01431	1	0.13327	1	0.077139	1	0.068189	1
12p loss	33 (18%)	151	0.097089	1	0.00102	0.583	0.02841	1	0.0011	0.627	0.00266	1	0.00199	1	0.01428	1	0.00022	0.13
12q loss	31 (17%)	153	0.16504	1	0.0027	1	0.074659	1	0.01347	1	0.02464	1	0.01242	1	0.0090499	1	0.0070899	1
13q loss	67 (36%)	117	0.01628	1	0.066409	1	0.24917	1	0.04807	1	0.04311	1	0.14791	1	0.058409	1	0.1048	1
14q loss	45 (24%)	139	0.00053999	0.313	0.00497	1	0.00216	1	0.00254	1	0.02937	1	0.00305	1	0.03706	1	0.00099999	0.573
15q loss	57 (31%)	127	0.28503	1	0.02996	1	0.25942	1	0.50889	1	0.096929	1	0.0055599	1	0.32271	1	0.00080999	0.467
16p loss	54 (29%)	130	0.00048	0.279	0.00014	0.084	0.00204	1	0.00032	0.188	0.00024	0.142	0.00016	0.0957	0.00032	0.188	0.00013	0.0781
16q loss	53 (29%)	131	9.9999e-06	0.0064	2e-05	0.0125	0.00041	0.239	0.00015	0.0898	9.9999e-06	0.0064	3e-05	0.0185	9.9999e-06	0.0064	9.9999e-06	0.0064
17p loss	71 (39%)	113	0.00237	1	9.9999e-05	0.0603	0.00323	1	0.00165	0.931	9.9999e-06	0.0064	0.00131	0.741	0.062029	1	0.00011	0.0662
17q loss	25 (14%)	159	0.79168	1	0.60544	1	0.87062	1	0.92015	1	0.51638	1	0.88813	1	0.36286	1	0.86795	1
18p loss	71 (39%)	113	0.0121	1	0.00090999	0.522	0.22215	1	0.04172	1	0.00115	0.653	0.02333	1	0.02505	1	0.0058099	1
18q loss	102 (55%)	82	0.097449	1	0.01138	1	0.11807	1	0.23678	1	0.02132	1	0.00229	1	0.04738	1	0.00035	0.205
19p loss	65 (35%)	119	0.04912	1	0.39272	1	0.21916	1	0.23572	1	0.062289	1	0.12131	1	0.095679	1	0.0094299	1
19q loss	52 (28%)	132	0.00451	1	0.11148	1	0.30674	1	0.060189	1	0.059439	1	0.093499	1	0.01882	1	0.0090899	1
20p loss	19 (10%)	165	0.58215	1	0.85838	1	0.55474	1	0.18968	1	0.59769	1	0.41894	1	0.68664	1	0.48011	1
20q loss	8 (4%)	176	0.89911	1	0.7042	1	0.26521	1	0.3168	1	1	1	0.67424	1	0.74685	1	0.44463	1
21q loss	106 (58%)	78	0.03135	1	0.0059999	1	0.058789	1	0.25752	1	0.02065	1	0.14671	1	0.04249	1	0.085119	1
22q loss	72 (39%)	112	5e-05	0.0305	9.9999e-06	0.0064	0.01982	1	0.087189	1	5.9999e-05	0.0364	0.00016	0.0957	3e-05	0.0185	2e-05	0.0125
xq loss	43 (23%)	141	0.01524	1	0.03141	1	0.27237	1	0.12285	1	0.16742	1	0.00061999	0.358	0.03524	1	0.01461	1
