rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(3), GABRA3(2), GABRA4(3), GABRA5(1), GABRA6(3)	3395416	12	12	12	2	5	3	0	4	0	0	0.209	0.000717	0.442
2	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(1), IL12B(1), IL18(2)	1280747	4	4	4	1	1	0	1	2	0	0	0.619	0.0113	1.000
3	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT2(1), AGPAT3(1), AGPS(1), ENPP2(2), PAFAH1B1(2), PAFAH1B3(1), PAFAH2(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PLD1(3)	9987119	19	18	19	1	3	5	2	7	2	0	0.0323	0.0115	1.000
4	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACPP(3), ENPP1(1), ENPP3(2), FLAD1(1), TYR(2)	4172365	9	9	9	1	3	3	0	1	2	0	0.206	0.0167	1.000
5	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPP(4), ALPPL2(2), FPGS(2), SPR(1)	2821312	9	8	9	2	3	2	1	1	2	0	0.429	0.0192	1.000
6	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX3(1), FADS2(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4)	4369144	9	9	9	0	1	3	0	3	2	0	0.0742	0.0193	1.000
7	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	20	CFL1(1), LIMK1(3), MAP3K1(2), MYLK(1), NCF2(1), PAK1(1), PDGFRA(7), PLD1(3), TRIO(2), VAV1(3)	13426396	24	23	24	2	7	6	1	4	6	0	0.0219	0.0259	1.000
8	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(2), CDC34(1), CUL1(1), RB1(3), SKP2(1)	3677825	8	8	8	0	0	2	0	1	5	0	0.252	0.0318	1.000
9	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	11	EGF(3), MET(4), PDGFRA(7), PRKCA(1), SH3KBP1(1)	7227860	16	14	16	2	2	5	0	4	5	0	0.168	0.0418	1.000
10	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(1), ANKRD1(1), HBEGF(1), IFRD1(2), IL18(2), IL1R1(1), NR4A3(1)	4628694	9	9	9	1	2	3	0	1	3	0	0.302	0.0449	1.000
11	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	5	PLCB1(2), PLCG1(4), PRKCA(1), VAV1(3)	3899907	10	10	9	2	3	3	0	3	1	0	0.380	0.0608	1.000
12	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F2(3), F5(4), F7(1), FGA(1), FGB(1), FGG(1), PROS1(1)	7048274	12	12	12	1	4	4	0	2	2	0	0.0625	0.0657	1.000
13	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BRAF(3), CREB3(3), MAPK1(1), RAF1(1)	4799126	8	8	8	0	0	2	0	2	4	0	0.222	0.0701	1.000
14	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CDKN1B(1), CUL1(1), RB1(3), SKP2(1), UBE2M(1)	3686822	7	7	7	0	0	2	0	1	4	0	0.218	0.0736	1.000
15	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(1), TAT(1), TYR(2)	2028505	4	4	4	1	2	0	1	1	0	0	0.583	0.0786	1.000
16	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACPP(3), ENPP1(1), ENPP3(2), FLAD1(1), MTMR6(1), TYR(2)	6468112	10	10	10	1	3	4	0	1	2	0	0.147	0.0892	1.000
17	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	LPO(3), MPO(2), TPO(3), TYR(2)	4164396	10	9	10	2	6	2	0	2	0	0	0.267	0.0968	1.000
18	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(1), FHL5(1), FSHR(1), GNAS(3), XPO1(1)	4125185	7	7	7	1	2	1	1	2	1	0	0.468	0.116	1.000
19	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	GABRA1(3), GABRA3(2), GABRA4(3), GABRA5(1), GABRA6(3)	5158397	12	12	12	3	5	3	0	4	0	0	0.384	0.119	1.000
20	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	CYCS(1), SDHA(3), SDHC(1), UQCRC1(1)	2845533	6	5	5	0	2	3	0	1	0	0	0.128	0.120	1.000
21	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(2), PC(1), PDHA1(3), SLC25A1(1)	3999603	7	7	7	1	0	2	0	3	2	0	0.306	0.121	1.000
22	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	14	CDKN1B(1), CDKN2A(1), CFL1(1), MDM2(2), PRB1(2)	3278740	7	6	7	0	0	3	0	2	2	0	0.105	0.121	1.000
23	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(2), NAT2(2), XDH(2)	3425900	6	6	6	0	4	0	0	1	1	0	0.134	0.123	1.000
24	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(1), CHRNA1(2)	1400897	3	3	3	0	1	1	0	0	1	0	0.300	0.125	1.000
25	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1)	3680157	7	7	7	1	5	0	0	0	2	0	0.240	0.126	1.000
26	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	RB1(3), SP3(2)	2857372	5	5	5	1	0	1	0	0	4	0	0.718	0.126	1.000
27	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	6	EEA1(1), EGF(3), HGS(2), TFRC(2)	4376211	8	7	8	1	3	2	0	2	1	0	0.271	0.128	1.000
28	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	LARS(1), PDHA1(3), PDHA2(2), PDHB(1)	4316140	7	7	7	1	0	4	0	2	1	0	0.287	0.130	1.000
29	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CDC34(1), CUL1(1), FBXW7(1), RB1(3)	3551777	6	6	6	0	1	1	0	0	4	0	0.301	0.133	1.000
30	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IL12B(1), IL15(1), IL16(3), IL18(2), IL6(1), TNF(1)	4265951	9	9	9	2	2	2	1	3	1	0	0.413	0.134	1.000
31	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(1), GNAS(3), PRKAR1A(2)	2849516	6	6	6	1	3	0	0	2	1	0	0.562	0.144	1.000
32	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(2), ENPP1(1), ENPP3(2), NADSYN1(1), NNMT(1), NT5C(2), NT5E(1)	6271908	10	10	10	2	1	6	1	1	1	0	0.264	0.145	1.000
33	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	CHAT(1), PDHA1(3), PDHA2(2)	3014484	6	6	6	1	0	3	0	1	2	0	0.348	0.152	1.000
34	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(1), COQ5(2)	1732532	3	3	3	0	0	2	0	1	0	0	0.387	0.158	1.000
35	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1)	5706969	12	12	12	3	6	1	0	2	3	0	0.292	0.160	1.000
36	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACPP(3), ALPP(4), ALPPL2(2), CYP3A4(2), CYP3A7(1), DHRS2(1), DHRSX(1), PON1(2)	7756665	16	15	16	3	6	3	0	2	5	0	0.208	0.166	1.000
37	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	MAX(3), SP3(2)	2687143	5	5	4	0	2	1	0	1	1	0	0.228	0.167	1.000
38	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1)	2424150	5	5	5	2	1	1	0	2	1	0	0.678	0.183	1.000
39	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	12	ARPC1B(1), PAK1(1), PDGFRA(7)	4140536	9	8	9	2	0	4	0	1	4	0	0.654	0.191	1.000
40	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(2), AGTR2(1), NOS3(3), REN(1)	4301265	7	7	7	1	4	1	0	0	2	0	0.334	0.192	1.000
41	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1)	709762	1	1	1	0	0	0	0	1	0	0	0.818	0.195	1.000
42	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3)	3450254	7	7	7	2	4	1	0	0	2	0	0.427	0.197	1.000
43	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3)	3450254	7	7	7	2	4	1	0	0	2	0	0.427	0.197	1.000
44	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(2), CCNE2(1), CDKN1B(1), CDKN2A(1), PRB1(2)	3867390	7	6	7	0	0	4	0	1	2	0	0.135	0.202	1.000
45	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(4), ACACB(5), ACAT2(1), ACSS1(2), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), LDHA(1), LDHAL6B(1), LDHB(1), PC(1), PCK1(1), PDHA1(3), PDHA2(2), PDHB(1), PKLR(1)	20185247	31	31	31	4	13	9	0	6	3	0	0.0129	0.202	1.000
46	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLUD1(2), GLUD2(1)	1963832	3	3	3	1	0	1	0	2	0	0	0.767	0.204	1.000
47	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(1), IDI1(1)	1355720	2	2	2	0	0	1	0	0	1	0	0.661	0.215	1.000
48	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(1), B3GNT5(2), ST3GAL3(1), ST3GAL4(1)	3100421	5	5	5	0	2	2	0	0	1	0	0.130	0.221	1.000
49	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	LPO(3), MPO(2), TPO(3)	3611032	8	7	8	2	5	2	0	1	0	0	0.376	0.223	1.000
50	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(2), ICAM1(1), ITGA4(1), ITGAL(2), ITGB2(1), SELE(3)	5209546	10	10	9	3	6	3	0	0	1	0	0.315	0.229	1.000
51	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(2)	790850	2	2	2	1	1	0	0	1	0	0	0.845	0.229	1.000
52	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(1), NR3C1(1), PPARG(1), RXRA(1), TNF(1)	2499615	5	5	5	2	0	3	0	2	0	0	0.658	0.243	1.000
53	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	4	EGF(3), ERBB3(1), NRG1(1)	3299667	5	5	5	0	2	1	0	1	1	0	0.301	0.244	1.000
54	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(2), PTGS1(1), PTGS2(1)	2299258	4	4	4	1	3	0	0	1	0	0	0.588	0.246	1.000
55	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(2), CCNB1(1), CDKN1B(1), CDKN2A(1), CDKN2C(1), RB1(3)	6920181	9	9	9	0	0	3	0	1	5	0	0.136	0.247	1.000
56	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	16	CSNK2A1(1), FOS(1), MAPK8(1), PLCG1(4), RAF1(1), SHC1(1)	6610587	9	9	8	1	0	6	0	1	2	0	0.169	0.253	1.000
57	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	EPHX2(2), HSD3B7(1)	2068630	3	3	3	1	1	0	0	2	0	0	0.731	0.254	1.000
58	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	HGD(2)	955265	2	2	2	1	0	0	0	1	1	0	0.941	0.254	1.000
59	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADS(2), ECHS1(1), HADHA(2)	2323924	5	5	5	2	1	1	0	1	2	0	0.642	0.282	1.000
60	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ASL(1), CPS1(2), GLUD1(2)	3364346	5	4	5	1	0	0	0	2	3	0	0.813	0.283	1.000
61	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	18	EIF4A1(2), EIF4A2(1), EIF4B(1), EIF4G1(3), EIF4G3(3), MKNK1(1), TSC1(1), TSC2(2)	9931741	14	13	14	1	3	6	0	3	2	0	0.0763	0.285	1.000
62	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), HLA-DRA(1)	1022309	2	2	2	0	1	0	0	1	0	0	0.573	0.285	1.000
63	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(1), HDC(2), TH(1)	2613399	4	4	4	1	2	1	0	1	0	0	0.510	0.304	1.000
64	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	HK1(3), PFKL(1), PGK1(1), PKLR(1)	4009994	6	6	6	0	2	3	0	0	1	0	0.0839	0.315	1.000
65	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	30	CYP1A2(2), CYP2C8(1), CYP3A4(2), CYP3A7(1), HSD3B7(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4)	9854519	14	14	14	2	4	3	0	5	2	0	0.218	0.323	1.000
66	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	DPYS(2), ENPP1(1), ENPP3(2), ILVBL(1), PANK2(1), PANK4(1), VNN1(1)	7451094	9	9	9	0	2	1	0	1	5	0	0.172	0.332	1.000
67	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(1), CA1(1), CA12(1), CA5A(1), CPS1(2), GLUD1(2), HAL(1)	8183484	9	9	9	1	2	1	1	3	2	0	0.290	0.335	1.000
68	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1), GLUD1(2)	2380799	3	3	3	1	0	0	0	3	0	0	0.811	0.337	1.000
69	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(1), IDI1(1)	1820386	2	2	2	0	0	1	0	0	1	0	0.660	0.342	1.000
70	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	TAT(1)	1134964	1	1	1	1	0	0	1	0	0	0	0.909	0.354	1.000
71	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	GAD2(1), GGT1(2)	2482497	3	3	3	0	2	1	0	0	0	0	0.290	0.356	1.000
72	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(1), FOS(1), JAK2(1), MAPK8(1), PLCG1(4), RAF1(1), SHC1(1), STAT5B(1)	9265220	11	11	10	1	0	6	0	2	3	0	0.111	0.359	1.000
73	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(4), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), LDHA(1), LDHB(1), PC(1), PCK1(1), PDHA1(3), PDHA2(2), PDHB(1), PKLR(1)	15944748	23	23	23	3	7	9	0	4	3	0	0.0327	0.359	1.000
74	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	CHAT(1), DBH(1), DDC(1), GAD2(1), HDC(2), PAH(1), TH(1)	6224415	8	8	8	1	4	1	0	1	2	0	0.242	0.359	1.000
75	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CXCR4(1), FOS(1), MAPK8(1), PLCG1(4), PRKCA(1), PTK2B(1)	5942948	9	9	8	2	1	6	1	0	1	0	0.303	0.361	1.000
76	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	AGPAT2(1), AGPAT3(1), AGPS(1), CHAT(1), DGKA(1), DGKD(2), DGKH(1), DGKQ(1), GNPAT(1), LGALS13(2), LYPLA1(1), PAFAH1B1(2), PAFAH2(1), PLA2G3(1), PLA2G4A(4), PLCB2(3), PLCG1(4), PLCG2(4)	21556210	32	31	31	4	10	10	1	5	6	0	0.0291	0.362	1.000
77	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(3), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH3B2(1), ALDH7A1(1), CNDP1(1), DDC(1), FTCD(3), HAL(1), HARS(1), HDC(2), PRMT5(2), PRMT8(1), PRPS1(1), PRPS2(1)	17087446	25	25	25	4	14	4	2	2	3	0	0.0373	0.377	1.000
78	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	20	CSNK2A1(1), FOS(1), JAK2(1), PLCG1(4), PRKCA(1), RAF1(1), RASA1(2), SHC1(1), STAT3(1), STAT5B(1)	11274022	14	14	13	2	2	5	0	3	4	0	0.191	0.380	1.000
79	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	26	BRAF(3), ERBB2(1), ERBB4(1), ETS1(1), ETV6(2), FMN2(2), KRAS(1), MAPK1(1), NOTCH2(5), NOTCH3(4), NOTCH4(5), PIWIL2(2), PIWIL3(1), RAF1(1), SOS2(1), SPIRE1(1)	19707474	32	31	32	5	10	7	1	7	6	1	0.0620	0.382	1.000
80	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	CDC25B(1), MYT1(2), RB1(3), WEE1(1), YWHAH(1)	7210131	8	8	8	0	1	0	0	0	7	0	0.273	0.386	1.000
81	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	HLA-DRA(1), IL12B(1), IL15(1), IL6(1), PDGFA(1), TNF(1)	5660428	6	6	6	1	1	2	1	2	0	0	0.361	0.390	1.000
82	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	DPYS(2), ENPP1(1), ENPP3(2), PANK2(1), PANK4(1)	6002900	7	7	7	0	2	1	0	0	4	0	0.247	0.391	1.000
83	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	11	GH1(1), GHR(1), IGF1R(2), SHC1(1)	4117537	5	5	5	0	0	2	0	2	1	0	0.204	0.405	1.000
84	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(1), GALNT4(1), GALNT6(1), ST3GAL1(1), ST3GAL4(1), WBSCR17(4)	6220936	9	9	9	2	4	1	1	2	1	0	0.451	0.421	1.000
85	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	FUT8(1), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1)	3403392	4	4	4	1	2	1	1	0	0	0	0.541	0.422	1.000
86	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	15	ADRB2(1), ANXA1(2), GNAS(3), NOS3(3), NR3C1(1)	6126607	10	10	10	2	5	2	0	1	2	0	0.330	0.427	1.000
87	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(1), ADRB2(1), CFTR(3), GNAS(3), PRKACG(1), PRKAR1A(2)	5651014	11	11	11	3	4	3	0	2	2	0	0.577	0.428	1.000
88	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(1), FUT5(1), ST3GAL3(1)	2187968	3	3	3	0	1	1	0	0	1	0	0.425	0.430	1.000
89	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ADCY1(1), CCNB1(1), GNAI1(3), GNAS(3), MAPK1(1), MYT1(2), PRKACG(1), PRKAR1A(2), RPS6KA1(1)	8874125	15	15	15	3	3	3	0	4	5	0	0.426	0.431	1.000
90	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	UXS1(2)	1644272	2	2	2	1	0	1	0	0	1	0	0.900	0.432	1.000
91	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR2(2), PDE1A(1), PDE1B(1), PLCB1(2), PLCB2(3)	4807619	9	9	9	3	3	2	0	2	2	0	0.632	0.453	1.000
92	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), CYP4F3(4), GGT1(2), LPO(3), LTA4H(1), MPO(2), PLA2G3(1), PLA2G4A(4), PTGES2(1), PTGS1(1), PTGS2(1), TPO(3)	12053396	25	24	25	5	10	5	0	6	4	0	0.111	0.458	1.000
93	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	24	CSNK2A1(1), FOS(1), MAP3K1(2), MAPK8(1), PDGFA(1), PDGFRA(7), PLCG1(4), PRKCA(1), RAF1(1), RASA1(2), SHC1(1), SRF(1), STAT3(1)	13429390	24	22	23	5	4	10	0	3	7	0	0.249	0.463	1.000
94	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(1), CDC25B(1), SHH(1), XPO1(1)	3734420	4	4	4	0	1	3	0	0	0	0	0.205	0.464	1.000
95	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	DLG4(1), F2(3), F2RL1(2), MAP2K5(1), MAPK1(1), MAPK7(3), MAPK8(1), PLD1(3), RAF1(1), RASAL1(1), TEC(1), VAV1(3)	11848811	21	19	21	4	5	5	1	6	4	0	0.177	0.471	1.000
96	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	9	ACLY(2), ACO1(1), ACSS1(2)	5022664	5	5	5	1	1	1	0	2	1	0	0.472	0.477	1.000
97	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(2)	2091986	2	2	2	1	0	2	0	0	0	0	0.739	0.478	1.000
98	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(1), FUCA1(1), FUCA2(2), HEXA(1), LCT(2), MAN2C1(1), NEU1(1), NEU2(2)	7140484	11	11	11	3	3	2	1	3	2	0	0.545	0.483	1.000
99	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	LPO(3), MPO(2), MTHFR(1), TPO(3)	4999800	9	8	9	2	5	2	0	2	0	0	0.341	0.485	1.000
100	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	CREBBP(4), PRF1(1)	4558722	5	5	5	1	2	1	0	1	1	0	0.600	0.485	1.000
101	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(2), APOBEC4(1)	3154212	3	3	3	1	0	1	0	1	1	0	0.703	0.488	1.000
102	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNAS(3), PRKACG(1), PRKAR1A(2), PRKCA(1)	4147641	7	7	7	2	3	0	0	2	2	0	0.792	0.498	1.000
103	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(1), DDIT3(1), MAP2K6(1), MAP3K1(2), MAP3K5(2), MAPKAPK5(2), MAX(3), MKNK1(1), PLA2G4A(4), RIPK1(1), SHC1(1), TGFBR1(1), TRADD(1)	15799654	21	20	20	3	4	9	0	5	3	0	0.106	0.503	1.000
104	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	LPO(3), MPO(2), TPO(3)	5090866	8	7	8	2	5	2	0	1	0	0	0.368	0.504	1.000
105	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	31	APC(1), AR(1), BRAF(3), DAG1(1), GNAI1(3), ITPR1(2), ITPR2(4), ITPR3(4), MAPK1(1), PHKA2(2), PITX2(1), PTX3(1), RAF1(1)	20294428	25	25	25	3	4	8	1	8	4	0	0.0685	0.510	1.000
106	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), HLA-DRA(1)	1711473	2	2	2	0	1	0	0	1	0	0	0.584	0.511	1.000
107	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	20	ADCY1(1), BAX(1), CSF2RB(1), IGF1R(2), KIT(2), PRKACG(1), PRKAR1A(2), YWHAH(1)	7836161	11	10	11	2	2	1	0	3	5	0	0.443	0.515	1.000
108	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	MARCKS(1), NFATC1(1), NFATC2(2), NFATC4(1), PLCG1(4), PRKCA(1), SP3(2)	9029438	12	12	11	2	3	4	0	1	4	0	0.264	0.520	1.000
109	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	HLA-DRA(1)	1311478	1	1	1	1	0	0	0	1	0	0	0.945	0.520	1.000
110	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	15	MAPK1(1), MAPK7(3), PLCG1(4), RPS6KA1(1), SHC1(1)	6544260	10	9	9	2	0	5	0	3	2	0	0.410	0.524	1.000
111	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(2), ACE2(1), AGTR2(1), CMA1(1), CTSG(1), ENPEP(4), NLN(1), REN(1), THOP1(1)	9136516	13	13	13	3	4	3	0	3	3	0	0.359	0.524	1.000
112	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	17	CSNK2A1(1), FOS(1), IGF1R(2), IRS1(2), MAPK8(1), RAF1(1), RASA1(2), SHC1(1), SRF(1)	8545865	12	12	12	3	1	5	0	2	4	0	0.399	0.525	1.000
113	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT2(1)	1454369	1	1	1	0	0	0	0	1	0	0	0.819	0.532	1.000
114	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	SNCA(1), SNCAIP(1), UBE2G2(1)	2775440	3	3	3	0	3	0	0	0	0	0	0.282	0.533	1.000
115	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GGT1(2)	1793900	2	2	2	0	1	1	0	0	0	0	0.440	0.542	1.000
116	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(4), PRKCA(1), PTK2B(1)	2902475	7	7	6	3	2	4	0	0	1	0	0.636	0.551	1.000
117	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	C1GALT1(1), GALNT1(1), GALNT14(1), GALNT4(1), GALNT5(1), GALNT6(1), GALNTL1(1), GALNTL4(1), GALNTL5(1), OGT(5), ST3GAL1(1), ST6GALNAC1(1), WBSCR17(4)	13919571	20	20	20	4	5	5	1	5	4	0	0.325	0.555	1.000
118	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	UXS1(2)	2097000	2	2	2	1	0	1	0	0	1	0	0.901	0.555	1.000
119	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(1), PLCB1(2)	3080286	3	3	3	1	0	0	0	2	1	0	0.755	0.556	1.000
120	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(1)	912723	1	1	1	0	0	0	0	1	0	0	0.810	0.562	1.000
121	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	FOS(1), MAPK1(1), MAPK8(1), PRKCA(1)	3834844	4	4	4	1	1	3	0	0	0	0	0.455	0.563	1.000
122	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1)	1686724	1	1	1	0	0	0	0	1	0	0	0.818	0.568	1.000
123	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(1), PRKCA(1)	2138681	2	2	2	1	1	0	0	1	0	0	0.802	0.569	1.000
124	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(2), ICAM1(1), ITGAL(2), ITGB2(1), SELE(3)	4479835	9	9	8	4	6	2	0	0	1	0	0.537	0.570	1.000
125	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	20	CDKN1B(1), MAPK1(1), NFKBIA(1), PAK1(1), RAF1(1), RB1(3)	7090736	8	8	8	2	0	1	0	0	7	0	0.645	0.573	1.000
126	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(3), LCT(2), PYGL(1)	5792937	6	6	6	1	2	2	0	0	2	0	0.257	0.575	1.000
127	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), MAP3K1(2), MAP3K5(2), MAPK8(1), NFKBIA(1), TNFRSF9(2), TNFSF9(1)	8327115	10	10	10	2	2	4	0	0	4	0	0.396	0.581	1.000
128	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	NR1H3(1), RXRA(1)	2340728	2	2	2	1	0	1	1	0	0	0	0.777	0.581	1.000
129	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG5(3), IFNA21(1), IFNA5(1), PIK3R4(1), PRKAA1(1), ULK2(1)	9096352	8	8	8	1	1	3	0	2	2	0	0.222	0.585	1.000
130	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	14	MAP2K3(1), MAP2K6(1), MAP3K1(2), MAPK1(1), RB1(3)	6749635	8	8	8	2	2	2	0	0	4	0	0.561	0.586	1.000
131	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CFL1(1)	1670598	1	1	1	0	0	0	0	0	1	0	0.659	0.593	1.000
132	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	BRAF(3), DAG1(1), ITPR1(2), ITPR2(4), ITPR3(4), MAPK1(1), PI3(1), PITX2(1), PLCB1(2), PLCB2(3), PLCB4(1), RAF1(1), SHC1(1), SOS2(1), STAT3(1)	24091490	27	27	27	3	6	8	1	10	2	0	0.0311	0.597	1.000
133	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST3A1(1), XYLT1(2)	2861050	3	3	3	0	1	2	0	0	0	0	0.262	0.598	1.000
134	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST3A1(1), XYLT1(2)	2861050	3	3	3	0	1	2	0	0	0	0	0.262	0.598	1.000
135	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(2), ICAM1(1), ITGA4(1), ITGAL(2), ITGB2(1), SELE(3), SELP(1)	6871726	11	11	10	4	6	3	0	1	1	0	0.429	0.605	1.000
136	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(3), CR2(2), HLA-DRA(1), ICAM1(1), ITGAL(2), ITGB2(1), PTPRC(3)	6542998	13	12	13	4	7	2	0	2	2	0	0.373	0.605	1.000
137	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	HLA-DRA(1), PTPRC(3), ZAP70(2)	3895662	6	6	6	2	2	2	0	2	0	0	0.642	0.607	1.000
138	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST3GAL1(1), ST3GAL4(1)	2438625	2	2	2	1	1	0	1	0	0	0	0.859	0.612	1.000
139	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSS(1), TNF(1), XDH(2)	4275718	4	4	4	1	2	1	0	0	1	0	0.493	0.615	1.000
140	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	FDPS(1), IDI1(1), MVD(1), NSDHL(2)	5685804	5	5	5	0	2	1	0	1	1	0	0.257	0.620	1.000
141	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	CHPF(1), CHST11(1), CHST13(1), CHSY1(1), DSE(1), XYLT1(2)	6090316	7	7	7	1	3	2	0	2	0	0	0.245	0.621	1.000
142	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(4), MAP2(2), PRKACG(1)	7821214	7	7	7	0	0	2	0	0	5	0	0.332	0.622	1.000
143	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	7	SDHA(3)	3710442	3	3	2	0	1	2	0	0	0	0	0.301	0.633	1.000
144	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(4), PRKAA1(1)	6227744	5	5	5	1	3	2	0	0	0	0	0.422	0.633	1.000
145	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(1), ACACA(4), ACACB(5), ACAT2(1), ACSS1(2), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH6A1(1), ALDH7A1(1), ECHS1(1), HADHA(2), LDHA(1), LDHAL6B(1), LDHB(1)	17105171	27	26	27	5	13	5	0	6	3	0	0.0834	0.638	1.000
146	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25B(1), WEE1(1)	2943558	2	2	2	1	1	0	0	0	1	0	0.942	0.653	1.000
147	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	BAX(1), MDM2(2), RB1(3)	7439297	6	6	6	0	0	1	0	1	4	0	0.261	0.657	1.000
148	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	CDC25B(1), MYT1(2), WEE1(1), YWHAH(1)	5927391	5	5	5	0	1	0	0	0	4	0	0.409	0.669	1.000
149	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(3)	3629332	3	3	3	0	1	2	0	0	0	0	0.313	0.674	1.000
150	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	HEXA(1), IDS(1), LCT(2), NAGLU(2)	6232259	6	6	6	1	2	2	0	0	2	0	0.391	0.674	1.000
151	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	14	CD28(1), CTLA4(1), HLA-DRA(1)	3357228	3	3	3	1	2	0	0	1	0	0	0.727	0.675	1.000
152	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	9	EGF(3), MAP3K1(2), NCOR2(3), RXRA(1), THRA(1)	6333818	10	10	10	3	4	3	0	1	2	0	0.525	0.677	1.000
153	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GGT1(2)	2376239	2	2	2	0	1	1	0	0	0	0	0.449	0.679	1.000
154	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(1), BAG4(1), CRADD(1), LMNA(1), LMNB2(1), MADD(1), MAP3K1(2), MAPK8(1), PAK1(1), PRKDC(3), RB1(3), RIPK1(1), SPTAN1(2), TNF(1), TRADD(1)	16624676	21	19	21	3	6	5	1	3	6	0	0.125	0.681	1.000
155	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SRP72(1), SRPR(1)	3246178	2	2	2	1	2	0	0	0	0	0	0.815	0.682	1.000
156	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(2), DAG1(1), ITPR1(2), ITPR2(4), ITPR3(4), NFKBIA(1), PDK1(2), PHKA2(2), PITX2(1), PLD1(3)	19345027	22	22	22	3	6	4	2	9	1	0	0.0903	0.682	1.000
157	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATR(1), CCNB1(1), CDC25B(1), CDC34(1), CHEK2(1), MDM2(2), MYT1(2), PRKDC(3), RPS6KA1(1), WEE1(1), YWHAH(1)	17566222	15	15	15	1	2	3	1	4	5	0	0.110	0.685	1.000
158	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	IL6(1), LPL(1)	2295534	2	2	2	0	0	0	0	2	0	0	0.699	0.687	1.000
159	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	23	CSNK2A1(1), EGF(3), FOS(1), MAP3K1(2), MAPK8(1), PLCG1(4), PRKCA(1), RAF1(1), RASA1(2), SHC1(1), SRF(1), STAT3(1)	13391750	19	18	18	4	4	8	0	3	4	0	0.242	0.689	1.000
160	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFS1(1), NDUFV2(1)	3003480	2	2	2	0	0	0	0	1	1	0	0.832	0.689	1.000
161	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	ABAT(1), ACADS(2), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ECHS1(1), GAD2(1), HADHA(2), L2HGDH(1), PDHA1(3), PDHA2(2), PDHB(1)	11125911	22	21	22	6	7	5	0	4	6	0	0.205	0.690	1.000
162	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	12	GH1(1), GHR(1), NFKBIA(1), YWHAH(1)	4442296	4	4	4	1	0	1	0	1	2	0	0.661	0.696	1.000
163	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B4GALNT1(1), HEXA(1), LCT(2), SLC33A1(1), ST3GAL1(1), ST6GALNAC3(1), ST8SIA5(1)	7099090	8	8	8	2	4	0	1	1	2	0	0.597	0.704	1.000
164	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	13	CDKN2A(1), MDM2(2), POLR1A(1), RB1(3), TBX2(1)	6766464	8	8	8	2	0	2	0	2	4	0	0.693	0.706	1.000
165	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	36	EEF1A2(1), EEF1D(2), EIF2AK3(1), EIF2B4(1), EIF2S2(1), EIF4A1(2), EIF4A2(1), EIF4G1(3), EIF4G3(3), GSPT2(2), KIAA0664(5), PABPC1(2)	18794112	24	21	24	4	6	4	2	5	7	0	0.161	0.706	1.000
166	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	25	ACLY(2), ACO1(1), IDH3B(1), OGDHL(1), PC(1), PCK1(1), SDHA(3), SDHC(1)	12154246	11	11	10	1	3	5	0	1	2	0	0.0683	0.709	1.000
167	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS2(1), PPOX(1)	3284851	2	2	2	1	0	1	0	1	0	0	0.805	0.709	1.000
168	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	LDHA(1), LDHB(1), NCL(1)	3852719	3	3	3	0	0	1	0	1	1	0	0.562	0.710	1.000
169	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(1), HADHA(2)	2085196	3	3	3	3	0	1	0	1	1	0	0.924	0.712	1.000
170	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	18	ACO1(1), IDH3B(1), PC(1), PCK1(1), SDHA(3)	8166719	7	7	6	0	1	5	0	0	1	0	0.0619	0.713	1.000
171	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	LDHA(1), LDHB(1)	2949177	2	2	2	0	0	1	0	1	0	0	0.563	0.714	1.000
172	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP9(1), RECK(1), TIMP4(1)	3249643	3	3	3	1	2	0	0	0	1	0	0.644	0.719	1.000
173	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	HEXA(1), HYAL1(1), IDS(1), LCT(2), NAGLU(2), SPAM1(1)	8863126	8	8	8	1	3	2	0	1	2	0	0.278	0.720	1.000
174	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	P2RY2(1), P2RY6(1)	2572781	2	2	2	1	1	1	0	0	0	0	0.716	0.722	1.000
175	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CD28(1), CTLA4(1), DAG1(1), FBXW7(1), LAT(1), MAPK1(1), NCK1(1), NFAT5(2), NFKBIA(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PLCG1(4), PTPRC(3), RAF1(1), RASGRP2(1), RASGRP4(1), SOS2(1), VAV1(3), ZAP70(2)	24023237	30	26	29	3	9	11	0	4	6	0	0.00813	0.723	1.000
176	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	MST1(3), TNF(1)	2826765	4	4	4	2	1	2	0	0	1	0	0.701	0.725	1.000
177	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	CYP11A1(1), CYP11B1(1), HSD3B2(1)	3988391	3	3	3	0	1	0	0	2	0	0	0.478	0.734	1.000
178	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	CYP11A1(1), CYP11B1(1), HSD3B2(1)	3988391	3	3	3	0	1	0	0	2	0	0	0.478	0.734	1.000
179	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(1), CREBBP(4), GNAS(3), HLA-DRA(1), PRKACG(1), PRKAR1A(2), PTPRC(3), ZAP70(2)	9917795	17	16	17	4	6	3	0	5	3	0	0.484	0.735	1.000
180	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(1), CREBBP(4), GNAS(3), HLA-DRA(1), PRKACG(1), PRKAR1A(2), PTPRC(3), ZAP70(2)	9917795	17	16	17	4	6	3	0	5	3	0	0.484	0.735	1.000
181	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	LDHA(1), LDHAL6B(1), LDHB(1), SULT1C2(1)	5405420	4	4	4	1	1	1	0	1	1	0	0.676	0.743	1.000
182	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(1), GNAS(3), PRKAA1(1), PRKACG(1), PRKAR1A(2)	6623564	8	8	8	2	4	0	0	2	2	0	0.689	0.744	1.000
183	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(3), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH3B2(1), CNDP1(1), DDC(1), HAL(1), HARS(1), HDC(2), PRPS1(1), PRPS2(1)	10532488	19	18	19	5	11	3	1	2	2	0	0.209	0.745	1.000
184	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	FBP2(1), G6PC(3), HK1(3), HK3(1), LDHA(1), LDHAL6B(1), LDHB(1), PC(1), PCK1(1), PDHA1(3), PDHA2(2), PDHB(1), PFKL(1), PGAM2(1), PGK1(1), PKLR(1)	18321219	23	22	23	3	6	11	0	4	2	0	0.0208	0.746	1.000
185	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1)	1679431	1	1	1	1	0	1	0	0	0	0	0.890	0.751	1.000
186	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	IFNGR2(1), JAK2(1), NFKBIA(1), RB1(3), TNF(1)	7474957	7	7	7	2	0	1	0	0	6	0	0.693	0.752	1.000
187	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD28(1)	1382645	1	1	1	1	1	0	0	0	0	0	0.903	0.753	1.000
188	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	29	IDH3B(1), PC(1), PDHA1(3), PDHA2(2), PDHB(1), PDK1(2), PDK3(1), SDHA(3), SDHC(1)	11880539	15	13	14	3	2	6	0	4	3	0	0.199	0.760	1.000
189	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(1), COL4A4(1), COL4A5(3), COL4A6(3), F2(3), F5(4), F8(3), FGA(1), FGB(1), FGG(1), KLKB1(3), PROS1(1), SERPING1(2)	19133764	27	26	27	6	10	8	1	3	5	0	0.104	0.762	1.000
190	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(2), PRKACG(1)	4350880	3	3	3	1	0	1	0	1	1	0	0.819	0.765	1.000
191	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), RIPK1(1), TNF(1), TRADD(1)	3632122	4	4	4	2	1	1	0	1	1	0	0.818	0.766	1.000
192	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	10	PLCG1(4), PRKCA(1), SHC1(1)	5075677	6	6	5	2	1	3	0	1	1	0	0.639	0.766	1.000
193	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	HEXA(1), ST3GAL1(1), ST3GAL4(1)	4366757	3	3	3	1	1	0	1	0	1	0	0.792	0.769	1.000
194	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(1), CDC25B(1), PRKCA(1)	3971069	3	3	3	1	2	1	0	0	0	0	0.600	0.773	1.000
195	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADS(2), ACADVL(1), ACSL1(3), ACSL4(1), HADHA(2), PECR(1)	7247921	10	10	10	3	1	3	0	2	4	0	0.578	0.775	1.000
196	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	FARS2(2), PAH(1), TAT(1)	3575269	4	4	4	2	1	1	1	0	1	0	0.812	0.776	1.000
197	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(1), JAK2(1), TYK2(2)	4519814	5	5	5	2	1	0	1	0	3	0	0.716	0.777	1.000
198	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(1), JAK2(1), TYK2(2)	4519814	5	5	5	2	1	0	1	0	3	0	0.716	0.777	1.000
199	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS2(1), DHRSX(1), HSD3B7(1), PON1(2)	3872099	5	5	5	2	1	1	0	1	2	0	0.782	0.780	1.000
200	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	DHRS2(1), DHRSX(1), PRMT5(2), PRMT8(1)	6472756	5	5	5	0	1	3	1	0	0	0	0.140	0.787	1.000
201	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	IARS2(1), ILVBL(1), LARS(1), PDHA1(3), PDHA2(2), PDHB(1)	8019112	9	9	9	2	0	4	0	3	2	0	0.440	0.787	1.000
202	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(4), ACACB(5), FASN(1), OXSM(1)	6885313	11	11	11	4	5	3	0	1	2	0	0.524	0.792	1.000
203	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	FDPS(1), IDI1(1), MVD(1)	4771411	3	3	3	0	0	1	0	1	1	0	0.550	0.796	1.000
204	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	HK1(3), HK3(1), PGM3(1)	4410998	5	5	5	2	0	3	0	1	1	0	0.626	0.798	1.000
205	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	CREB3(3), IL1R1(1), MAP2K3(1), MAP2K6(1), MAP3K10(1), MAP3K4(2), MAP3K5(2), MAPK1(1), MAPK12(1), MAPKAPK5(2), MKNK1(1), SRF(1)	14388816	17	17	17	4	1	7	0	5	4	0	0.496	0.800	1.000
206	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(1)	1627024	1	1	1	0	1	0	0	0	0	0	0.612	0.800	1.000
207	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	RAB27A(1)	1818191	1	1	1	0	1	0	0	0	0	0	0.642	0.802	1.000
208	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	HK1(3), HK3(1), ISYNA1(1), PGM3(1)	5043619	6	6	6	2	0	4	0	1	1	0	0.507	0.802	1.000
209	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	GGT1(2), MARS2(1), SCLY(1)	5336322	4	4	4	1	1	2	1	0	0	0	0.464	0.802	1.000
210	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(2), ATP6V1C2(1), ATP6V1D(1), ATP7A(1), COX7B(1), NDUFS1(1), NDUFV2(1), SDHA(3), UQCRC1(1), UQCRH(1)	16441971	13	13	12	0	4	5	0	3	1	0	0.0172	0.807	1.000
211	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(1), CREB3(3), DAG1(1), FOS(1), MAPK1(1), MAPK8(1), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1)	12366981	11	11	11	0	1	4	0	3	3	0	0.0750	0.807	1.000
212	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CYP11A1(1), HSD3B2(1)	2975165	2	2	2	1	1	0	0	1	0	0	0.875	0.808	1.000
213	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(1), PRKCA(1)	3885763	2	2	2	1	1	0	0	1	0	0	0.823	0.808	1.000
214	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	AGTR2(1), EGF(3), FOS(1), PLCG1(4), PRKCA(1)	7703232	10	9	9	3	3	5	0	1	1	0	0.461	0.809	1.000
215	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR2(1), JAK2(1)	3515158	2	2	2	2	0	0	0	0	2	0	0.965	0.812	1.000
216	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(3)	2604049	3	3	3	2	2	1	0	0	0	0	0.806	0.812	1.000
217	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(1), ACAD9(1), ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), DHRS2(1), DHRSX(1), ESCO2(1)	10743125	10	10	10	2	2	2	0	4	2	0	0.406	0.814	1.000
218	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(2), PAH(1), TAT(1)	3748069	4	4	4	2	1	1	1	0	1	0	0.819	0.815	1.000
219	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(1), CA1(1), CA12(1), CA5A(1), CPS1(2), GLUD1(2), GLUD2(1), HAL(1)	9149707	10	10	10	3	2	2	1	3	2	0	0.580	0.816	1.000
220	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	MAP2K3(1), MAP3K1(2), MAPK1(1), MAPK8(1), PAK1(1), PLCG1(4), PRKCA(1), PTK2B(1), RAF1(1), SHC1(1)	12303490	14	14	13	3	3	7	0	1	3	0	0.249	0.818	1.000
221	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2E1(1), GTF2H4(1), GTF2IRD1(1), TAF1(4), TAF1L(2), TAF2(1), TAF4(1), TAF6(1), TAF9B(1), TBPL2(1)	15500100	14	14	14	2	5	3	0	4	2	0	0.182	0.822	1.000
222	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(1), FOS(1), JAK2(1), RAF1(1), SHC1(1), STAT5B(1)	7612079	6	6	6	1	0	1	0	2	3	0	0.485	0.824	1.000
223	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(1), ADRB2(1), GNAS(3), PLCE1(3), PRKACG(1), PRKAR1A(2), RAP2B(1)	6371572	12	12	12	4	4	2	0	3	3	0	0.763	0.829	1.000
224	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(1), FOS(1), IL6(1), IL6ST(2), JAK2(1), JAK3(1), RAF1(1), SHC1(1), SRF(1), STAT3(1)	9789152	11	11	11	3	1	3	0	4	3	0	0.498	0.829	1.000
225	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHA4(3), L1CAM(1), SELP(1)	6795425	5	5	5	1	2	1	0	2	0	0	0.538	0.830	1.000
226	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), UBE2G2(1), UBE2M(1)	4537963	3	3	3	1	1	1	0	0	1	0	0.813	0.830	1.000
227	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(2), ANXA2(2), ANXA3(1), ANXA6(1), CYP11A1(1), PLA2G4A(4), PTGS1(1), PTGS2(1)	8878976	13	13	13	4	4	3	1	4	1	0	0.459	0.830	1.000
228	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMPR1B(1)	2711112	1	1	1	2	0	0	0	0	1	0	1.000	0.831	1.000
229	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	25	ACOT11(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), DHRS2(1), DHRSX(1), ECHS1(1), ESCO2(1), HADHA(2)	12865657	14	14	14	3	7	2	0	1	4	0	0.254	0.831	1.000
230	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	DAG1(1)	2626253	1	1	1	0	0	1	0	0	0	0	0.655	0.838	1.000
231	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	EIF2S2(1), NFKBIA(1)	3864581	2	2	2	1	0	0	0	1	1	0	0.819	0.839	1.000
232	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(1)	2116549	1	1	1	0	1	0	0	0	0	0	0.682	0.843	1.000
233	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	18	CSNK2A1(1), FOS(1), IRS1(2), MAPK8(1), RAF1(1), RASA1(2), SHC1(1), SRF(1)	8853828	10	10	10	3	1	4	0	2	3	0	0.562	0.847	1.000
234	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), FAF1(1), LMNA(1), LMNB2(1), MAP3K1(2), MAPK8(1), PAK1(1), PRKDC(3), RB1(3), SPTAN1(2)	17421833	16	15	16	2	3	4	1	2	6	0	0.178	0.850	1.000
235	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(3), BAX(1), MAPK8(1), MDM2(2)	8600415	7	7	7	2	1	2	1	1	2	0	0.550	0.850	1.000
236	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), ECHS1(1), HADHA(2), HSD17B4(2)	3650855	6	6	6	3	0	2	0	2	2	0	0.836	0.852	1.000
237	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	24	ATR(1), CCNA1(2), CDKN1B(1), CDKN2A(1), RB1(3), SKP2(1)	12640102	9	9	9	1	1	1	0	2	5	0	0.430	0.856	1.000
238	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	CRADD(1), MAP2K3(1), MAP2K6(1), MAP3K1(2), MAPK8(1), NFKBIA(1), RIPK1(1), TANK(2), TNF(1), TRADD(1)	10446813	12	12	12	3	5	4	0	0	3	0	0.308	0.858	1.000
239	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	PTK2B(1), SHC1(1)	3807867	2	2	2	1	0	1	0	1	0	0	0.813	0.859	1.000
240	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASDHPPT(1)	2035737	1	1	1	0	0	0	0	0	1	0	0.719	0.861	1.000
241	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	INPP4B(1), INPPL1(1), OCRL(2), PIK3C2B(1), PIK3CG(2), PLCB1(2), PLCB2(3), PLCB4(1), PLCG1(4), PLCG2(4)	18343144	21	20	20	4	7	7	1	5	1	0	0.160	0.864	1.000
242	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	16	EIF2S2(1), IGF1R(2), INPPL1(1)	6494197	4	4	4	1	0	2	0	1	1	0	0.516	0.865	1.000
243	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(1)	2647639	1	1	1	1	0	1	0	0	0	0	0.880	0.865	1.000
244	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	18	IL18(2), KLRC2(1), LAT(1), PAK1(1), PTK2B(1), VAV1(3)	6396362	9	8	9	3	3	3	0	2	1	0	0.571	0.867	1.000
245	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR6(1)	2763690	1	1	1	0	0	1	0	0	0	0	0.676	0.869	1.000
246	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT2(1)	3086050	1	1	1	0	0	0	0	1	0	0	0.823	0.871	1.000
247	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	BAX(1), CASP8AP2(1)	4641159	2	2	2	0	0	0	0	0	2	0	0.691	0.871	1.000
248	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	FOS(1), MAP2K3(1), MAP2K6(1), MAP3K1(2), MAPK8(1), NFKBIA(1), TLR10(1), TLR2(1), TLR3(1), TLR6(2), TLR7(2), TLR9(2), TOLLIP(1)	15759099	17	17	17	4	7	4	0	3	3	0	0.272	0.873	1.000
249	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1B(1), ADRB2(1), CHRM1(1), CHRM3(3), CHRM5(1), DRD5(3), HRH1(1), HTR1B(2), HTR1E(1), HTR2A(1), HTR2B(2), HTR4(1), HTR5A(1)	11095685	19	18	19	5	8	3	0	3	5	0	0.261	0.874	1.000
250	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	EGF(3), MAPK1(1), PTPRB(2), RAF1(1), RASA1(2), SHC1(1), SPRY2(1), SPRY4(1)	9603030	12	10	12	3	1	3	0	3	5	0	0.423	0.877	1.000
251	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	GRIN1(1), JAK2(1), NFKBIA(1)	5465414	3	3	3	1	0	0	0	0	3	0	0.749	0.880	1.000
252	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(2), ENPP1(1), ENPP3(2), NADSYN1(1), NNMT(1), NT5C(2), NT5E(1)	9271810	10	10	10	3	1	6	1	1	1	0	0.437	0.881	1.000
253	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	CHRM1(1), CHRNA1(2), FLT4(1), KDR(4), NOS3(3), PDE2A(1), PDE3A(1), PRKACG(1), PRKAR1A(2), PRKG2(1), RYR2(10), TNNI1(1)	17456491	28	27	28	7	8	7	1	7	5	0	0.190	0.882	1.000
254	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(3), CACNA1A(2), CACNA1B(4), GNAS(3), GRM4(3), ITPR3(4), KCNB1(3), PDE1A(1), PLCB2(3), PRKACG(1), SCNN1B(1), TAS1R2(2), TAS1R3(1), TAS2R1(2), TAS2R16(2), TAS2R4(2), TAS2R40(2), TAS2R41(1), TAS2R9(1), TRPM5(1)	24573015	42	39	42	9	17	7	1	10	7	0	0.123	0.882	1.000
255	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(4), LPL(1), NCOA1(1), NCOA2(1), PPARG(1), RXRA(1)	7953781	9	9	9	3	1	4	0	3	1	0	0.628	0.883	1.000
256	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(3), ABCB4(3), ABCC3(1)	6171322	7	7	7	3	1	1	1	2	2	0	0.825	0.885	1.000
257	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	28	CABIN1(2), HDAC5(1), IGF1R(2), MAP2K6(1), MAPK7(3), NFATC1(1), NFATC2(2), YWHAH(1)	13395083	13	12	13	2	2	3	1	2	5	0	0.198	0.886	1.000
258	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS2(1), CPO(1)	3415162	2	2	2	2	0	1	0	0	1	0	0.881	0.891	1.000
259	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(2), PTPRU(1), REG1A(1), TYK2(2)	5388859	6	6	6	3	1	1	0	1	3	0	0.862	0.893	1.000
260	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(1), FOS(1), THBS1(1)	3184347	3	3	3	2	0	2	0	0	1	0	0.800	0.894	1.000
261	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AP2M1(1), BIN1(1), SYNJ1(1), SYNJ2(3)	9282683	6	6	6	1	2	2	0	1	1	0	0.409	0.895	1.000
262	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT2(1), ECHS1(1), HADHA(2)	3360048	4	4	4	4	0	1	0	2	1	0	0.952	0.896	1.000
263	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(4), PML(1), RB1(3), SP100(2), TNF(1)	7841643	11	11	11	4	3	2	0	2	4	0	0.729	0.897	1.000
264	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(6), C6(1), C7(2), C8A(2)	5386542	11	11	11	6	5	2	0	1	3	0	0.791	0.898	1.000
265	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(2), TYK2(2)	4669623	4	4	4	3	1	0	0	1	2	0	0.952	0.899	1.000
266	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	FOS(1), POLR2A(1), PRKACG(1), PRKAR1A(2)	5563314	5	5	5	2	2	1	0	1	1	0	0.781	0.900	1.000
267	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	IL1R1(1), IL6(1), IRAK3(1), MAP2K3(1), MAP2K6(1), MAP3K1(2), MAPK8(1), NFKBIA(1), TNF(1), TOLLIP(1)	12794546	11	11	11	2	3	5	0	1	2	0	0.194	0.900	1.000
268	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	CHST11(1), CHST13(1), SULT2B1(2)	3959948	4	3	4	2	1	0	0	2	1	0	0.865	0.900	1.000
269	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(1), FOS(1), GNAI1(3), GNAS(3), NFATC1(1), NFATC2(2), NFATC4(1), PLCG1(4), PRKACG(1), PRKAR1A(2), PRKCA(1), RAF1(1), RPS6KA3(1)	15077643	22	22	21	5	6	5	0	5	6	0	0.320	0.902	1.000
270	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	31	DOCK1(1), FOS(1), HGF(2), MAPK1(1), MAPK8(1), MET(4), PAK1(1), PTK2B(1), RAF1(1), RASA1(2), STAT3(1)	16509278	16	15	16	3	2	6	0	2	6	0	0.201	0.903	1.000
271	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ARPC1B(1)	3494857	1	1	1	1	0	1	0	0	0	0	0.899	0.904	1.000
272	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BRAF(3), CREB3(3), MAPK1(1), MKNK1(1), RPS6KA1(1), RPS6KA3(1), SHC1(1), SOS2(1)	12728816	12	12	12	3	0	3	0	6	3	0	0.658	0.906	1.000
273	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIA(1), GFPT1(1), GFPT2(2), GNPDA1(1), HEXA(1), HK1(3), HK3(1), MTMR6(1), PGM3(1), RENBP(3)	12384265	15	15	15	4	2	6	0	4	3	0	0.432	0.906	1.000
274	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(1), ACAT2(1), ECHS1(1), HADHA(2)	3600996	5	5	5	3	0	2	0	2	1	0	0.833	0.907	1.000
275	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	HEXA(1), ST3GAL1(1)	4634004	2	2	2	1	0	0	1	0	1	0	0.919	0.907	1.000
276	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(1), ABP1(3), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), CNDP1(1), DPYS(2), ECHS1(1), GAD2(1), HADHA(2)	11632891	18	17	18	5	9	2	0	2	5	0	0.308	0.908	1.000
277	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	FDPS(1), IDI1(1), MVD(1), NSDHL(2)	8309818	5	5	5	1	2	1	0	1	1	0	0.555	0.908	1.000
278	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(2), CD44(2), TNF(1), TNFSF8(1)	5664869	6	6	6	3	2	3	0	0	1	0	0.711	0.909	1.000
279	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ECHS1(1), HADHA(2)	5245847	10	10	10	5	4	2	0	1	3	0	0.689	0.912	1.000
280	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATR(1), BRCA2(2), CHEK2(1), FANCC(1), FANCD2(2), FANCE(2), RAD17(1), RAD50(1), RAD9A(1), TREX1(1)	18617278	13	13	13	2	2	5	0	3	3	0	0.288	0.913	1.000
281	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	GFPT1(1), GNPDA1(1), HEXA(1), HK1(3), HK3(1), PGM3(1), RENBP(3)	7320472	11	11	11	4	1	5	0	3	2	0	0.613	0.913	1.000
282	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	PRMT5(2), PRMT8(1)	6064239	3	3	3	0	0	2	1	0	0	0	0.317	0.913	1.000
283	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	DNMT1(1), DNMT3A(4), DNMT3B(1), MARS2(1)	7506034	7	7	7	2	2	2	0	2	1	0	0.471	0.914	1.000
284	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(1), ADCY3(1), ADCY9(2), ATP6V0A2(1), ATP6V1C2(1), ATP6V1D(1), ERO1L(1), GNAS(3), PLCG1(4), PLCG2(4), PRKCA(1)	15919630	20	19	19	4	10	5	0	2	3	0	0.181	0.915	1.000
285	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(1), EXT2(1), EXTL1(2), HS3ST3A1(1), HS6ST2(2), NDST2(1), NDST3(2)	8957134	10	10	10	3	4	1	1	3	1	0	0.499	0.917	1.000
286	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	APC(1), DAG1(1), DLG4(1), GNAI1(3), ITPR1(2), ITPR2(4), ITPR3(4), MAPK1(1), PITX2(1), PTX3(1), RYR1(7)	19746251	26	24	26	5	4	8	2	8	4	0	0.138	0.920	1.000
287	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	GGT1(2), MARS2(1), PRMT5(2), PRMT8(1), SCLY(1)	10751059	7	7	7	1	1	4	2	0	0	0	0.206	0.921	1.000
288	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	MAP3K1(2), NFATC1(1), NFATC2(2), NFKBIA(1), PLCG1(4), PRKACG(1), PRKAR1A(2)	12065408	13	12	12	3	3	4	0	2	4	0	0.350	0.929	1.000
289	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(4), MAP2K3(1), MAP2K6(1), NFKBIA(1), NR3C1(1), TGFBR1(1), TGFBR2(1), TLR2(1), TNF(1)	12817917	12	12	12	3	3	4	0	2	3	0	0.386	0.930	1.000
290	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	CISH(1), IL13RA1(1), IL4R(1), JAK2(1), JAK3(1), PI3(1), SHC1(1), SOS2(1), STAT6(2), TYK2(2)	14984405	12	12	12	2	3	0	1	5	3	0	0.325	0.930	1.000
291	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(1), IL6(1), JAK2(1), JAK3(1), PIAS3(1), PTPRU(1), REG1A(1), STAT3(1)	6582758	8	8	8	3	2	1	0	3	2	0	0.671	0.931	1.000
292	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATR(1), CHEK2(1), YWHAH(1)	6520951	3	3	3	0	1	1	0	0	1	0	0.528	0.931	1.000
293	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	39	BRAF(3), CREB3(3), CREBBP(4), DAG1(1), MAP1B(2), MAPK1(1), MAPK8(1), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1), RPS6KA3(1), SHC1(1), TH(1)	20069271	21	21	21	4	2	7	0	7	5	0	0.298	0.932	1.000
294	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(1), FTCD(3), GART(1), MTHFR(1)	8151769	6	6	6	2	3	0	0	1	2	0	0.635	0.933	1.000
295	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	40	FOS(1), LAT(1), MAP3K1(2), MAPK8(1), NFATC1(1), NFATC2(2), NFATC4(1), NFKBIA(1), PLCG1(4), PRKCA(1), RAF1(1), RASA1(2), SHC1(1), VAV1(3), ZAP70(2)	18998388	24	23	23	5	7	8	0	4	5	0	0.127	0.934	1.000
296	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(4), NCOA3(1), PRKACG(1), PRKAR1A(2), RXRA(1)	8917003	9	9	9	3	2	2	0	2	3	0	0.748	0.934	1.000
297	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSD(1), ARSE(1), GALC(1), LCT(2), NEU1(1), NEU2(2), SMPD2(1)	10453589	9	9	9	2	5	0	0	3	1	0	0.458	0.939	1.000
298	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	13	IGF1R(2), IRS1(2), MAPK1(1), RAF1(1), SHC1(1), YWHAH(1)	6545186	8	8	8	3	1	3	0	1	3	0	0.614	0.940	1.000
299	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	ETS1(1), ETV3(1), FOS(1), HDAC2(3), HDAC5(1), NCOR2(3), SIN3A(2)	11250231	12	11	12	3	2	1	1	1	7	0	0.716	0.942	1.000
300	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	BAX(1), CYCS(1)	5773392	2	2	2	0	0	0	0	1	1	0	0.589	0.942	1.000
301	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(1), DHRSX(1), ESCO2(1)	7119953	3	3	3	0	1	1	0	0	1	0	0.462	0.943	1.000
302	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	ICAM1(1), ITGAL(2), ITGB2(1), PRF1(1)	3774024	5	4	5	4	4	0	0	0	1	0	0.858	0.944	1.000
303	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDHPPT(1)	2997755	1	1	1	0	0	0	0	0	1	0	0.705	0.944	1.000
304	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	35	FOS(1), MAP3K1(2), MAPK1(1), MAPK8(1), NFATC1(1), NFATC2(2), NFATC4(1), PLA2G4A(4), PLCG1(4), RAF1(1), SHC1(1), VAV1(3)	16936022	22	20	21	5	5	9	0	5	3	0	0.186	0.944	1.000
305	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKBIA(1), PLCB1(2), PRKCA(1)	3553840	4	4	4	3	1	0	0	2	1	0	0.905	0.948	1.000
306	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	48	CALR(1), CREBBP(4), F2(3), GATA4(1), MAPK1(1), MAPK8(1), NFATC1(1), NFATC2(2), NFATC4(1), PRKACG(1), PRKAR1A(2), RAF1(1)	18542047	19	19	19	4	5	4	0	5	5	0	0.218	0.949	1.000
307	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK2(1), JAK3(1), MAPK1(1), STAT3(1), TYK2(2)	5083239	6	6	6	3	2	1	0	1	2	0	0.817	0.950	1.000
308	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	MAF(1), MAP2K3(1), NFATC1(1), NFATC2(2), PRKACG(1), PRKAR1A(2)	5267777	8	8	8	4	3	0	0	3	2	0	0.780	0.950	1.000
309	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), HLA-DRA(1), IFNGR2(1), IL12B(1), IL12RB1(1), IL18(2), IL4R(1)	5454629	8	8	8	5	2	0	1	3	2	0	0.905	0.950	1.000
310	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(1), JAK2(1), PTPRU(1), REG1A(1)	4913825	4	4	4	3	1	1	0	0	2	0	0.877	0.950	1.000
311	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	ECHS1(1), HADHA(2), HSD17B4(2)	5103202	5	5	5	3	0	1	0	2	2	0	0.904	0.951	1.000
312	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	7	ACO1(1)	3128015	1	1	1	0	0	1	0	0	0	0	0.679	0.951	1.000
313	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	20	BCR(1), FOS(1), JAK2(1), MAP3K1(2), MAPK8(1), RAF1(1), STAT5B(1)	10480010	8	8	8	2	1	4	0	1	2	0	0.376	0.952	1.000
314	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	ABAT(1), ACADS(2), ACAT2(1), ACSM1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), ECHS1(1), GAD2(1), HADHA(2), HSD17B4(2), HSD3B7(1), ILVBL(1), L2HGDH(1), PDHA1(3), PDHA2(2), PDHB(1)	17482181	27	26	27	7	8	4	0	7	8	0	0.222	0.952	1.000
315	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CLOCK(1), PER1(2)	3683670	3	3	3	3	0	1	0	1	1	0	0.971	0.952	1.000
316	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(1), CDH1(1), CREBBP(4), TGFBR1(1), TGFBR2(1)	11063197	8	8	8	2	3	2	0	2	1	0	0.520	0.953	1.000
317	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(2), ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH3B2(1), ALDH7A1(1), FBP2(1), G6PC(3), G6PC2(1), HK1(3), HK3(1), LDHA(1), LDHAL6B(1), LDHB(1), PDHA1(3), PDHA2(2), PDHB(1), PFKL(1), PGAM2(1), PGK1(1), PGM3(1), PKLR(1)	25089207	38	36	38	9	13	10	1	9	5	0	0.0740	0.954	1.000
318	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	FBP2(1), G6PD(2), PFKL(1), PGM3(1), PRPS1(1), PRPS1L1(1), PRPS2(1), TALDO1(1), TKTL2(1)	10480608	10	10	10	3	6	2	0	2	0	0	0.372	0.958	1.000
319	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(1), ICAM1(1), ITGAL(2), ITGB2(1), PTPRC(3)	4634569	8	7	8	4	5	1	0	1	1	0	0.667	0.958	1.000
320	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(1), ICAM1(1), ITGAL(2), ITGB2(1), PTPRC(3)	4860225	8	7	8	4	5	1	0	1	1	0	0.676	0.962	1.000
321	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(1), ACACA(4), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH6A1(1), ECHS1(1), HADHA(2), LDHA(1), LDHB(1)	14264471	19	18	19	5	7	5	0	4	3	0	0.311	0.962	1.000
322	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	ANKRD6(1), APC(1), CTNNB1(1), DKK2(2), LRP1(5), NKD2(1), SENP2(1), WIF1(2)	17407482	14	14	14	2	4	2	0	5	3	0	0.224	0.963	1.000
323	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	50	AKR1C3(2), ALOX12B(1), CYP2B6(1), CYP2C8(1), CYP4A11(1), CYP4A22(1), CYP4F3(4), EPHX2(2), GGT1(2), GPX2(1), LTA4H(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PTGES2(1), PTGS1(1), PTGS2(1)	16367341	27	27	27	7	9	5	0	9	4	0	0.249	0.965	1.000
324	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	SREBF1(3)	5204811	3	2	3	0	0	2	0	1	0	0	0.351	0.966	1.000
325	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	F13B(1), HSD17B4(2), HSD3B2(1)	3487550	4	4	4	3	1	0	0	2	1	0	0.944	0.967	1.000
326	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	19	H2AFX(1), RAF1(1), RALA(1), RALGDS(2)	6607228	5	5	5	2	1	1	0	0	3	0	0.746	0.967	1.000
327	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), IFNAR1(2), MAPK8(1)	4779366	4	4	4	3	0	2	0	1	1	0	0.898	0.969	1.000
328	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	FN3K(1), INPP4B(1), INPPL1(1), ISYNA1(1), OCRL(2), PI4KA(2), PI4KB(2), PIK3CG(2), PIP4K2B(1), PIP4K2C(2), PLCB1(2), PLCB2(3), PLCB4(1), PLCD3(2), PLCE1(3), PLCG1(4), PLCG2(4), PLCZ1(1), PTPMT1(1), SYNJ1(1), SYNJ2(3)	30767722	40	39	39	8	10	12	1	8	9	0	0.148	0.971	1.000
329	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX3(1), FADS2(1), FASN(1), HADHA(2), PECR(1)	6238209	6	6	6	4	0	2	0	2	2	0	0.895	0.971	1.000
330	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	GREB1(2)	4723804	2	2	2	0	2	0	0	0	0	0	0.416	0.972	1.000
331	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(3), AMY2B(1), ENPP1(1), ENPP3(2), G6PC(3), GANAB(2), HK1(3), HK3(1), MGAM(3), PGM3(1), PYGB(1), PYGL(1), SI(4), UGT1A1(3), UGT2B4(1), UXS1(2)	24520261	32	30	32	6	10	11	0	7	4	0	0.0668	0.972	1.000
332	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	FBP2(1), G6PD(2), PGM3(1), PRPS1(1), PRPS1L1(1), PRPS2(1), TALDO1(1)	8812474	8	8	8	3	5	2	0	1	0	0	0.490	0.972	1.000
333	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ASPH(2), LDHA(1), NOS3(3)	7331427	6	5	6	2	3	1	0	2	0	0	0.599	0.972	1.000
334	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	ABAT(1), ADSL(1), AGXT2(1), ASL(1), ASNS(1), CAD(2), CRAT(1), GAD2(1), PC(1)	11236344	10	9	10	2	5	2	0	1	2	0	0.359	0.972	1.000
335	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	MAPK1(1), RAF1(1)	3552238	2	2	2	2	0	1	0	0	1	0	0.864	0.972	1.000
336	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH3B2(1), FBP2(1), G6PC(3), HK1(3), HK3(1), LDHA(1), LDHB(1), PDHA1(3), PDHA2(2), PDHB(1), PGK1(1), PGM3(1), PKLR(1)	21059834	32	31	32	8	9	11	1	6	5	0	0.108	0.973	1.000
337	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH3B2(1), FBP2(1), G6PC(3), HK1(3), HK3(1), LDHA(1), LDHB(1), PDHA1(3), PDHA2(2), PDHB(1), PGK1(1), PGM3(1), PKLR(1)	21059834	32	31	32	8	9	11	1	6	5	0	0.108	0.973	1.000
338	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(2), APOA1(1), APOA4(1), LIPC(1), LPL(1), LRP1(5), SCARB1(1), SOAT1(1)	11796740	13	13	13	4	4	3	0	5	1	0	0.545	0.973	1.000
339	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(1), B3GNT3(1), B3GNT4(1), B3GNT5(2), FUT5(1), ST3GAL6(1)	6989115	7	7	7	3	0	3	0	2	2	0	0.725	0.974	1.000
340	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(1), CREBBP(4), CSNK2A1(1), CTNNB1(1), WIF1(2)	12657940	9	9	9	2	1	3	0	2	3	0	0.479	0.975	1.000
341	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT7(1), CHST1(1), FUT8(1), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1)	5385912	6	6	6	3	3	2	1	0	0	0	0.702	0.975	1.000
342	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	ETV5(1), IL12B(1), IL12RB1(1), IL18(2), JAK2(1), MAP2K6(1), MAPK8(1), TYK2(2)	8053825	10	10	10	6	2	2	1	2	3	0	0.909	0.976	1.000
343	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSD(1), ARSE(1), DEGS1(1), GALC(1), LCT(2), NEU1(1), NEU2(2), SMPD2(1), SMPD3(1), SMPD4(1)	15432647	12	12	12	2	5	2	0	3	2	0	0.280	0.976	1.000
344	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	YWHAH(1)	3328052	1	1	1	0	0	0	0	0	1	0	1.000	0.976	1.000
345	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	IL12B(1), IL12RB1(1), JAK2(1), TYK2(2)	6351991	5	5	5	4	1	0	1	1	2	0	0.949	0.977	1.000
346	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	GGT1(2), LTA4H(1), PTGS1(1), PTGS2(1)	6507513	5	5	5	2	2	1	0	1	1	0	0.674	0.977	1.000
347	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), AGK(1), AGPAT2(1), AGPAT3(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), DGKA(1), DGKD(2), DGKH(1), DGKQ(1), GK(1), GK2(3), GPAM(1), LCT(2), LIPC(1), LIPG(1), LPL(1), PNLIPRP1(2)	25285723	32	26	32	6	14	8	1	5	4	0	0.0355	0.977	1.000
348	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(1), GART(1), MTHFR(1)	7692807	3	3	3	1	1	0	0	1	1	0	0.671	0.979	1.000
349	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	19	EIF4A1(2), EIF4A2(1), EIF4G1(3), EIF4G3(3), GHR(1), IRS1(2), MAPK1(1), MKNK1(1), PABPC1(2), PRKCA(1)	10147230	17	15	17	5	5	6	0	2	4	0	0.554	0.979	1.000
350	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	RPL10L(1), RPL37A(1), RPL7(1), RPS2(1), RPS24(1)	9704954	5	5	5	1	2	0	0	2	1	0	0.724	0.980	1.000
351	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C3(6), C6(1), C7(2), C8A(2), MBL2(2)	9142828	13	13	13	6	5	3	0	1	4	0	0.719	0.980	1.000
352	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C3(6), C6(1), C7(2), C8A(2)	7513172	11	11	11	6	5	2	0	1	3	0	0.793	0.980	1.000
353	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(1), ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), SOAT2(1), SRD5A1(1)	10006782	15	15	15	5	6	3	0	3	3	0	0.428	0.980	1.000
354	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V1C2(1), ATP6V1D(1)	6479542	2	2	2	0	1	1	0	0	0	0	0.457	0.980	1.000
355	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V1C2(1), ATP6V1D(1)	6479542	2	2	2	0	1	1	0	0	0	0	0.457	0.980	1.000
356	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V1C2(1), ATP6V1D(1)	6479542	2	2	2	0	1	1	0	0	0	0	0.457	0.980	1.000
357	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(1), JAK2(1), JAK3(1), PIAS3(1), PTPRU(1), REG1A(1), SOAT1(1)	5912503	7	7	7	5	1	1	0	3	2	0	0.942	0.980	1.000
358	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ASL(1), CPS1(2), GLUD1(2)	7581686	5	4	5	3	0	0	0	2	3	0	0.967	0.981	1.000
359	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	F13A1(2), F2(3), FGA(1), FGB(1), FGG(1)	5768302	8	8	8	4	3	2	0	2	1	0	0.730	0.982	1.000
360	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(1), CREBBP(4), CTNNB1(1), LDB1(1), PITX2(1), TRRAP(4)	14301196	12	12	12	3	5	2	0	3	2	0	0.438	0.984	1.000
361	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	AGPAT2(1), AGPAT3(1), CHAT(1), DGKA(1), DGKD(2), DGKH(1), DGKQ(1), ESCO2(1), GNPAT(1), GPAM(1), LYPLA1(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PLD1(3)	28246196	22	20	22	2	8	6	1	3	4	0	0.0289	0.985	1.000
362	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	PRF1(1), SREBF1(3)	7906605	4	3	4	1	1	2	0	1	0	0	0.603	0.985	1.000
363	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ARPC1B(1), NCK1(1), NCKAP1(2), WASF3(2)	6568726	6	5	6	3	2	2	0	1	1	0	0.722	0.985	1.000
364	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	11	MUSK(3), PTK2B(1), TERT(1), YWHAH(1)	5438412	6	5	6	4	1	2	0	1	2	0	0.926	0.986	1.000
365	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	28	G6PD(2), GGT1(2), GPX2(1), GSS(1)	7086690	6	6	6	3	3	2	0	1	0	0	0.715	0.986	1.000
366	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V1C2(1), ATP6V1D(1)	6897071	2	2	2	0	1	1	0	0	0	0	0.458	0.987	1.000
367	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), AGPAT2(1), AGPAT3(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), DGKA(1), DGKD(2), DGKH(1), DGKQ(1), GK(1), LCT(2), LIPC(1), LIPG(1), LPL(1), PNLIPRP1(2)	20776832	27	23	27	6	12	6	1	4	4	0	0.0907	0.988	1.000
368	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	28	GNAS(3), IGF1R(2), MAPK1(1), MKNK1(1), PDGFRA(7), PTPRR(2), RAF1(1), RPS6KA1(1), SHC1(1), STAT3(1)	13138576	20	19	20	6	2	7	0	4	7	0	0.572	0.989	1.000
369	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT2(1), ACOT11(1), DHRS2(1), DHRSX(1), ECHS1(1), ESCO2(1), FN3K(1), HADHA(2)	11166274	9	8	9	3	2	2	0	2	3	0	0.672	0.989	1.000
370	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	63	ADAM10(1), ATP6V0A2(1), ATP6V1C2(1), ATP6V1D(1), HBEGF(1), JAM2(1), MAPK12(1), MAPK8(1), MAPK9(1), MET(4), NFKBIA(1), PAK1(1), PLCG1(4), PLCG2(4), PTPRZ1(4), TCIRG1(1), TJP1(3)	28638365	31	29	30	5	7	11	0	3	10	0	0.0623	0.989	1.000
371	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	30	ACPP(3), ALPP(4), ALPPL2(2), CYP1A2(2), CYP2B6(1), CYP2C8(1), CYP3A4(2), CYP3A7(1), CYP4F8(1), PON1(2)	12168144	19	18	19	6	9	2	0	3	5	0	0.542	0.989	1.000
372	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	FBP2(1), PGK1(1), PKLR(1)	7793275	3	3	3	1	2	1	0	0	0	0	0.599	0.990	1.000
373	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMC3(1)	5546589	1	1	1	0	0	1	0	0	0	0	0.677	0.990	1.000
374	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(1), CYCS(1), MAP3K1(2), MAPK1(1), MAPK8(1), RAF1(1), RIPK1(1), TRADD(1)	8865443	9	9	9	4	2	3	0	1	3	0	0.683	0.990	1.000
375	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	31	BCR(1), CDKN2A(1), FLOT1(1), FLOT2(2), ITPR1(2), ITPR2(4), ITPR3(4), PDK1(2), PITX2(1), PLCG2(4), PREX1(2), PTPRC(3), RPS6KA1(1), RPS6KA3(1), SAG(1), TEC(1), VAV1(3)	22522003	34	30	34	9	12	7	1	14	0	0	0.296	0.990	1.000
376	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	CHEK2(1), MAPK8(1), MDM2(2), NFKBIA(1), RAD50(1), RBBP8(1)	12471252	7	7	7	2	0	5	0	1	1	0	0.502	0.990	1.000
377	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	30	MAPK1(1), MAPK12(1), MAPK8(1), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1), MAPKAPK5(2), NFKBIA(1)	12916679	9	9	9	2	1	3	0	3	2	0	0.411	0.991	1.000
378	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BNIP1(1), STX11(1), TSNARE1(1), USE1(1), VAMP5(2)	7208649	6	6	5	3	3	1	0	0	2	0	0.706	0.991	1.000
379	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(6), C6(1), C7(2), ICAM1(1), IL6(1), ITGA4(1), ITGAL(2), ITGB2(1), SELP(1), SELPLG(1), TNF(1)	10658859	18	18	18	8	7	5	0	2	4	0	0.522	0.991	1.000
380	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	FOS(1), MAPK1(1), NFKBIA(1), PLCB1(2), PRKCA(1), RAF1(1), TNF(1)	6692104	8	8	8	4	1	3	0	2	2	0	0.692	0.991	1.000
381	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	71	GAB2(1), KRAS(1), LAT(1), MAP2K3(1), MAP2K6(1), MAPK1(1), MAPK12(1), MAPK8(1), MAPK9(1), NRAS(1), PDK1(2), PIK3CG(2), PIK3R5(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PLCG1(4), PLCG2(4), PRKCA(1), RAC2(1), RAF1(1), SOS2(1), TNF(1), VAV1(3)	28741042	38	35	37	9	11	13	1	9	4	0	0.123	0.992	1.000
382	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), TGFBR1(1), TGFBR2(1)	4546608	3	3	3	2	2	1	0	0	0	0	0.809	0.992	1.000
383	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	CP(1), EPRS(1), HCCS(2), PPOX(1), UGT1A1(3), UGT2B4(1)	11797588	9	9	9	3	0	4	0	5	0	0	0.666	0.992	1.000
384	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CREBBP(4), NFKBIA(1), RIPK1(1), TNF(1), TRADD(1)	9661334	8	8	8	3	2	2	0	1	3	0	0.708	0.993	1.000
385	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	BAX(1), CYCS(1), PRKCA(1), TLN1(3)	11437186	6	6	6	2	2	0	0	3	1	0	0.672	0.993	1.000
386	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C3(6), C6(1), C7(2), C8A(2), C8B(1)	8931559	12	12	12	7	5	3	0	1	3	0	0.820	0.993	1.000
387	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	MAP3K1(2), NFKBIA(1), TNFAIP3(1)	7828857	4	4	4	2	2	1	0	0	1	0	0.719	0.994	1.000
388	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(1), ACAA2(1), ACADS(2), ACAT2(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH6A1(1), ALDH7A1(1), AOX1(2), DBT(1), ECHS1(1), HADHA(2), HSD17B4(2), MCCC1(1), MCCC2(2)	18519097	24	21	23	6	9	5	0	4	6	0	0.258	0.994	1.000
389	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	DAG1(1), ITPR1(2), ITPR2(4), ITPR3(4), NFAT5(2), PDE6B(3), PDE6C(3)	15443890	19	18	19	6	5	7	1	4	2	0	0.391	0.994	1.000
390	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	13	IGF1R(2), POLR2A(1), PRKCA(1), RB1(3), TEP1(2), TERT(1)	10663331	10	10	10	4	5	1	0	0	4	0	0.642	0.994	1.000
391	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	13	CDKN1B(1), MAPK1(1), SHC1(1)	6350293	3	3	3	2	0	1	0	1	1	0	0.888	0.994	1.000
392	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	20	ADCY1(1), GNAI1(3), MAPK1(1), PDGFA(1), PDGFRA(7), PLCB1(2), PRKCA(1), SMPD2(1)	10196942	17	15	17	6	4	5	0	4	4	0	0.677	0.995	1.000
393	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	42	BRAF(3), EIF4B(1), MAPK1(1), PGF(1), PIK3CG(2), PIK3R5(1), PRKAA1(1), RPS6KA1(1), RPS6KA3(1), RPS6KA6(1), TSC1(1), TSC2(2), ULK2(1), VEGFB(2), VEGFC(2)	21333206	21	20	20	5	3	5	3	9	1	0	0.319	0.995	1.000
394	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	GLI3(1), PRKACG(1), PRKAR1A(2), SHH(1), SUFU(1)	7202261	6	6	6	4	1	2	0	1	2	0	0.919	0.995	1.000
395	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(4), MAPK1(1)	6384633	5	5	5	3	1	2	0	1	1	0	0.898	0.995	1.000
396	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	UGT1A1(3), UGT2B4(1)	7577691	4	4	4	2	0	1	0	3	0	0	0.842	0.996	1.000
397	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL22RA1(1), JAK2(1), JAK3(1), STAT3(1), STAT5B(1), TYK2(2)	7950800	7	7	7	5	2	0	0	3	2	0	0.961	0.996	1.000
398	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1)	5504515	1	1	1	0	0	1	0	0	0	0	0.673	0.996	1.000
399	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGTR2(1), F2(3), GNAI1(3), JAK2(1), MAPK1(1), MAPK8(1), MYLK(1), PLCG1(4), PRKCA(1), PTK2B(1), RAF1(1), SHC1(1), STAT3(1)	17953288	20	19	19	5	4	8	0	3	5	0	0.241	0.996	1.000
400	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	MAP3K1(2), NFKBIA(1), RIPK1(1), TANK(2), TNFAIP3(1)	9689912	7	7	7	3	3	2	0	0	2	0	0.667	0.996	1.000
401	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	DLG4(1), GRIN1(1), GRIN2A(3), GRIN2B(3), GRIN2C(2), GRIN2D(2), NOS1(1), PRKACG(1), PRKAR1A(2), PRKCA(1)	11039485	17	16	17	9	5	2	0	6	4	0	0.902	0.996	1.000
402	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(1), ABP1(3), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), CNDP1(1), DPYS(2), ECHS1(1), GAD2(1), HADHA(2)	12519589	18	17	18	7	8	3	0	2	5	0	0.546	0.996	1.000
403	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	23	GH1(1), GHR(1), IRS1(2), JAK2(1), MAPK1(1), PLCG1(4), PRKCA(1), RAF1(1), RPS6KA1(1), SHC1(1), SRF(1), STAT5B(1)	12627301	16	16	15	5	2	6	0	4	4	0	0.526	0.996	1.000
404	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(2), HDAC2(3), NFATC1(1), NFATC2(2), PRKCA(1)	10507499	9	9	9	7	2	1	1	1	4	0	0.985	0.996	1.000
405	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(1), ALDH4A1(1), CAD(2), CPS1(2), EPRS(1), GAD2(1), GFPT1(1), GLUD1(2), GSS(1), NADSYN1(1)	14288654	13	13	13	4	3	4	0	3	3	0	0.621	0.996	1.000
406	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	BRAF(3), CACNA1A(2), GNAI1(3), GNAO1(3), GNAS(3), GRIA1(5), GRIA3(4), GRID2(1), GRM5(1), GUCY1A3(1), GUCY2C(2), GUCY2F(2), IGF1R(2), ITPR1(2), ITPR2(4), ITPR3(4), KRAS(1), MAPK1(1), NOS1(1), NOS3(3), NRAS(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PLCB1(2), PLCB2(3), PLCB4(1), PPP2R2C(1), PRKCA(1), PRKCG(1), PRKG2(1), RAF1(1), RYR1(7)	47597813	74	61	74	14	18	22	3	18	13	0	0.0113	0.996	1.000
407	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(1), FUCA1(1), FUCA2(2), HEXA(1), LCT(2), MAN2B1(1), MAN2B2(1), MAN2C1(1), NEU1(1), NEU2(2)	8803573	13	13	13	6	4	2	1	3	3	0	0.787	0.997	1.000
408	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	IL4R(1), IRS1(2), JAK3(1), SHC1(1), STAT6(2)	6395596	7	7	7	4	2	1	0	3	1	0	0.830	0.997	1.000
409	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR7(1), CD28(1), CXCR4(1), IFNGR2(1), IL12B(1), IL12RB1(1), IL4R(1)	8618564	7	7	7	7	1	1	2	1	2	0	0.980	0.997	1.000
410	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	SHC1(1)	6039555	1	1	1	1	0	0	0	1	0	0	0.946	0.997	1.000
411	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	BMPR1B(1), CDKN1B(1), DMC1(1), ESR2(2), FSHR(1), MLH1(2), MSH5(1), NCOR1(3), ZP2(1)	15109417	13	13	13	4	2	4	0	3	4	0	0.692	0.997	1.000
412	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(1)	5765659	1	1	1	0	0	1	0	0	0	0	0.673	0.997	1.000
413	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	23	ATF2(1), BCR(1), FOS(1), MAP3K1(2), MAPK1(1), MAPK8IP3(1), PAPPA(2), RPS6KA1(1), RPS6KA3(1), SHC1(1), VAV1(3)	13088827	15	15	15	5	3	4	0	7	1	0	0.650	0.997	1.000
414	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMC3(1)	6887116	1	1	1	1	0	1	0	0	0	0	0.947	0.997	1.000
415	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(1), ACADS(2), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH6A1(1), AOX1(2), ECHS1(1), HADHA(2), MCCC1(1), MCCC2(2)	15504048	20	19	19	7	7	6	0	3	4	0	0.423	0.997	1.000
416	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(3), ADC(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), ASL(1), ASS1(1), CPS1(2)	12722162	15	15	15	9	8	1	0	1	5	0	0.916	0.998	1.000
417	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN3(1), CTNNA2(1), CTNNB1(1), VCL(1)	8298512	4	4	4	2	1	0	0	2	1	0	0.884	0.998	1.000
418	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	GTF2E1(1), NCOA1(1), NCOA2(1), NCOA3(1), NCOR2(3), POLR2A(1), RXRA(1)	10772473	9	9	9	6	3	3	0	0	3	0	0.919	0.998	1.000
419	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG5(1), FUT8(1), MGAT2(1), MGAT3(2), MGAT5(1)	8605344	6	6	6	3	2	2	0	1	1	0	0.786	0.998	1.000
420	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(1), COL4A4(1), COL4A5(3), COL4A6(3), SLC23A1(1), SLC23A2(1), SLC2A3(1)	10797020	11	11	11	5	5	4	1	1	0	0	0.512	0.998	1.000
421	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	IL12B(1), ITGAX(1), TLR2(1), TLR7(2), TLR9(2)	8005526	7	6	7	4	2	0	1	3	1	0	0.916	0.998	1.000
422	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	PLCB1(2), PRKACG(1), PRKAR1A(2)	6918479	5	5	5	3	1	0	0	3	1	0	0.962	0.998	1.000
423	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(3), ALDH1A3(1), ALDH3A1(3), ALDH3B2(1), DDC(1), LPO(3), MPO(2), TAT(1), TPO(3)	9486911	18	17	18	7	10	3	2	1	2	0	0.486	0.998	1.000
424	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CFL1(1), GNAS(3), LIMK1(3), MAPK1(1), PLCB1(2), PRKCA(1), RAF1(1), ROCK2(1)	10807756	13	13	13	5	2	3	0	5	3	0	0.740	0.998	1.000
425	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(3), GNAI1(3), MAPK1(1), PLA2G4A(4), PLCB1(2), PRKCA(1), PTGS1(1), RAF1(1)	10509208	16	16	16	6	1	5	0	7	3	0	0.660	0.999	1.000
426	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	FBP2(1), PGK1(1), PKLR(1), TKTL2(1)	8709804	4	4	4	2	2	1	0	1	0	0	0.736	0.999	1.000
427	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	11	APC(1), CTNNB1(1)	7483069	2	2	2	3	0	0	0	1	1	0	0.997	0.999	1.000
428	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F13B(1), F2(3), F5(4), F7(1), F8(3), FGA(1), FGB(1), FGG(1), LPA(1), VWF(3)	15204486	19	17	19	7	6	5	1	3	4	0	0.458	0.999	1.000
429	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA2(1), ACAD8(1), ACAD9(1), ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), HSD3B7(1), SOAT1(1), SOAT2(1), SRD5A1(1)	13626237	19	18	19	7	7	2	0	7	3	0	0.593	0.999	1.000
430	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	21	CXCR4(1), GNAI1(3), MAPK1(1), PLCG1(4), PRKCA(1), PTK2B(1), RAF1(1)	10295871	12	12	11	5	1	6	1	1	3	0	0.655	0.999	1.000
431	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	ABP1(3), ESCO2(1)	10903635	4	4	4	2	2	1	0	0	1	0	0.809	0.999	1.000
432	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CLOCK(1), PER1(2), PER2(1)	7356377	4	4	4	3	0	2	0	1	1	0	0.929	0.999	1.000
433	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	FPR1(1), MAP2K3(1), MAP2K6(1), MAP3K1(2), MAPK1(1), NCF2(1), NFATC1(1), NFATC2(2), NFATC4(1), NFKBIA(1), PAK1(1), PLCB1(2), RAF1(1)	16501654	16	15	16	5	5	2	0	3	6	0	0.427	0.999	1.000
434	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	FOS(1), MAP3K1(2), MAPK8(1), NFATC1(1), NFATC2(2), NFATC4(1), PLCG1(4), PRKCA(1), RAF1(1), SHC1(1), VAV1(3)	16478915	18	17	17	6	6	6	0	3	3	0	0.436	0.999	1.000
435	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	CYCS(1), GAS2(1), LMNA(1), NFKBIA(1), RIPK1(1), SPTAN1(2), TRADD(1)	14415675	8	6	8	2	3	1	0	1	3	0	0.467	0.999	1.000
436	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	20	DIAPH1(2), MAPK1(1), MYLK(1), RAF1(1), SHC1(1), TLN1(3)	14440231	9	9	9	3	3	1	0	4	1	0	0.611	0.999	1.000
437	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	HDAC5(1), YWHAH(1)	8738915	2	2	2	1	1	0	0	0	1	0	0.888	0.999	1.000
438	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	ATF2(1), MAP3K1(2), MAPK1(1), MAPK8(1), PAK1(1), PRKCA(1), PTK2B(1), RAF1(1), SHC1(1)	13317147	10	10	10	4	2	4	0	1	3	0	0.688	0.999	1.000
439	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	17	ADCY1(1), F2(3), GNAI1(3), PLCB1(2), PRKCA(1), PTK2B(1)	9521223	11	11	11	5	2	3	0	4	2	0	0.772	0.999	1.000
440	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(1), ADRBK2(1), ARRB2(1), CALML3(1), CLCA1(1), CLCA2(1), CNGA3(1), CNGB1(1), GUCA1A(1), PDE1C(1), PRKACG(1), PRKG2(1)	13145628	12	11	12	7	4	1	0	3	4	0	0.867	0.999	1.000
441	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	14	CREBBP(4), IL7R(1), JAK3(1), PTK2B(1), STAT5B(1)	10451259	8	8	8	4	1	2	0	4	1	0	0.854	0.999	1.000
442	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	DNMT1(1), DNMT3A(4), DNMT3B(1), MARS2(1), TAT(1)	8945719	8	8	8	4	2	2	1	2	1	0	0.721	0.999	1.000
443	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	ARHGDIB(1), CASP1(1), CYCS(1), LMNA(1), LMNB2(1), PRF1(1)	8320667	6	5	6	3	2	2	0	2	0	0	0.815	0.999	1.000
444	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(1), AGTR2(1), CMA1(1), COL4A1(1), COL4A4(1), COL4A5(3), COL4A6(3), REN(1)	10866940	12	12	12	6	6	4	0	1	1	0	0.658	0.999	1.000
445	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	ATF2(1), IL1R1(1), MAP2K5(1), MAP3K1(2), MAP3K10(1), MAP3K12(2), MAP3K13(1), MAP3K4(2), MAP3K5(2), MAPK7(3), MAPK8(1), MAPK9(1), PAPPA(2), SHC1(1)	21359989	21	19	21	5	2	8	0	6	5	0	0.407	1.000	1.000
446	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	CES2(1), CYP3A4(2), UGT1A1(3)	9830157	6	6	6	3	1	1	0	3	1	0	0.856	1.000	1.000
447	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	IL1R1(1), MAP3K1(2), NFKBIA(1), RIPK1(1), TNF(1), TNFAIP3(1), TRADD(1)	10528674	8	8	8	5	3	3	0	0	2	0	0.863	1.000	1.000
448	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	30	ANGPTL2(1), DAG1(1), DGKA(1), ITPR1(2), ITPR2(4), ITPR3(4), MAPK1(1), PAK1(1), PDE3A(1), PI3(1), RPS4X(1)	19362765	18	17	18	5	2	8	1	6	1	0	0.423	1.000	1.000
449	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	FBP2(1), GMDS(1), HK1(3), HK3(1)	10334603	6	6	6	3	2	3	0	0	1	0	0.675	1.000	1.000
450	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(1), ATF2(1), BMP4(2), CTNNB1(1), GATA4(1), RFC1(1), TGFBR1(1), TGFBR2(1)	15690578	9	9	9	3	3	2	0	1	3	0	0.720	1.000	1.000
451	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	24	APC(1), CTNNB1(1), GJA1(1), GNAI1(3), LBP(1), TOLLIP(1)	11644811	8	8	8	4	1	1	0	3	3	0	0.922	1.000	1.000
452	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(1), FUCA1(1), FUCA2(2), HEXA(1), HYAL1(1), IDS(1), LCT(2), MAN2B1(1), MAN2B2(1), MAN2C1(1), NAGLU(2), NEU1(1), NEU2(2), SPAM1(1)	14915874	18	18	18	6	5	4	1	4	4	0	0.541	1.000	1.000
453	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(3), ALDH1A3(1), ALDH3A1(3), ALDH3B2(1), DDC(1), ESCO2(1), LPO(3), MPO(2), TAT(1), TPO(3)	14741023	19	18	19	7	10	3	2	1	3	0	0.499	1.000	1.000
454	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ACTB(1), ACTG1(1), ARHGEF2(2), CDH1(1), CTNNB1(1), CTTN(1), HCLS1(1), NCK1(1), NCL(1), PRKCA(1), ROCK2(1), TLR5(1), TUBA3C(2), TUBA3D(1), TUBB3(1), TUBB6(1), TUBB8(1), WAS(2)	22595341	21	21	21	6	8	2	3	3	5	0	0.413	1.000	1.000
455	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ACTB(1), ACTG1(1), ARHGEF2(2), CDH1(1), CTNNB1(1), CTTN(1), HCLS1(1), NCK1(1), NCL(1), PRKCA(1), ROCK2(1), TLR5(1), TUBA3C(2), TUBA3D(1), TUBB3(1), TUBB6(1), TUBB8(1), WAS(2)	22595341	21	21	21	6	8	2	3	3	5	0	0.413	1.000	1.000
456	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ALG6(1), CELSR1(5), CELSR2(1), CELSR3(5), CHRM3(3), EMR2(1), EMR3(1), FSHR(1), GNRHR(1), GPR116(4), GPR132(1), GPR133(1), GPR17(1), GRPR(3), HRH4(1), LPHN2(2), LPHN3(3), OR8G2(2), SSTR2(1), TAAR5(1), TSHR(2)	28768948	41	40	41	11	12	14	2	9	4	0	0.111	1.000	1.000
457	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	ABAT(1), ADSL(1), ADSSL1(1), AGXT2(1), ASL(1), ASNS(1), ASS1(1), CAD(2), CRAT(1), DARS2(1), GAD2(1), PC(1), PDHA1(3), PDHA2(2), PDHB(1)	16316557	19	17	19	5	7	6	0	3	3	0	0.329	1.000	1.000
458	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	UGT1A1(3), UGT2A3(1), UGT2B10(4), UGT2B11(3), UGT2B28(2), UGT2B4(1), UGT2B7(1)	11758667	15	14	15	6	2	3	0	10	0	0	0.762	1.000	1.000
459	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	EGF(3), ETS1(1), FOS(1), HOXA7(1), MAP2K3(1), MAP2K6(1), MAP3K1(2), MAP3K5(2), MAPK1(1), MAPK8(1), NFKBIA(1), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(1), RAF1(1), RIPK1(1), TNF(1)	20035434	22	22	22	7	6	9	1	2	4	0	0.305	1.000	1.000
460	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	24	ADCY1(1), GNAS(3), MAPK1(1), PRKACG(1), PRKAR1A(2), PRKCA(1), RPS6KA1(1)	10940559	10	10	10	5	4	1	0	3	2	0	0.901	1.000	1.000
461	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	61	CDKN1B(1), CDKN2A(1), CREB3(3), ERBB4(1), INPPL1(1), IRS1(2), IRS4(2), MET(4), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PDK1(2), PREX1(2), RPS6KA1(1), RPS6KA3(1), SHC1(1), SOS2(1), TSC1(1), TSC2(2), YWHAE(1), YWHAH(1)	32040013	32	30	32	7	3	6	0	16	7	0	0.332	1.000	1.000
462	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	94	ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADCY9(2), CACNA1D(1), CACNA1F(3), CACNA1S(5), CALML3(1), GNAS(3), GNRHR(1), HBEGF(1), ITPR1(2), ITPR2(4), ITPR3(4), KRAS(1), MAP2K3(1), MAP2K6(1), MAP3K1(2), MAP3K4(2), MAPK1(1), MAPK12(1), MAPK7(3), MAPK8(1), MAPK9(1), NRAS(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PLCB1(2), PLCB2(3), PLCB4(1), PLD1(3), PRKACG(1), PRKCA(1), PTK2B(1), RAF1(1), SOS2(1)	53834776	71	62	71	13	22	18	2	17	12	0	0.0123	1.000	1.000
463	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(1), POLR2A(1), POLR2B(1), POLR2G(1), POLR3A(3), POLR3B(1), POLR3GL(1), POLR3K(1)	10106462	10	10	10	6	2	4	1	2	1	0	0.875	1.000	1.000
464	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(2), POLD1(1), POLE(1), POLQ(2), PRIM1(1), PRIM2(2), REV1(3), REV3L(1)	17383018	13	11	13	7	5	2	0	2	4	0	0.958	1.000	1.000
465	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(1), NFKBIA(1), RIPK1(1), TNF(1), TNFAIP3(1), TRADD(1)	11749550	6	6	6	5	2	1	0	1	2	0	0.960	1.000	1.000
466	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	46	BRD4(1), CDKN2A(1), FLOT1(1), FLOT2(2), INPPL1(1), IRS1(2), IRS4(2), MAPK1(1), PDK1(2), PPYR1(1), RAF1(1), RPS6KA1(1), RPS6KA3(1), SHC1(1), SOS2(1), YWHAE(1), YWHAH(1)	23731203	21	20	21	5	3	5	0	10	3	0	0.375	1.000	1.000
467	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	57	BAX(1), CAD(2), CASP8AP2(1), DEDD2(1), FAF1(1), MAP3K1(2), MAP3K5(2), MAPK1(1), MAPK8(1), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1), MET(4), NFAT5(2), NFKBIA(1), RIPK1(1), TNFRSF6B(1), TPX2(1)	29821665	25	21	25	5	2	9	0	2	12	0	0.246	1.000	1.000
468	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	EPRS(1), FARS2(2), GARS(1), HARS(1), LARS(1), MARS2(1), RARS(1), WARS2(1)	13780686	9	9	9	4	1	6	0	2	0	0	0.707	1.000	1.000
469	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	G6PC(3), G6PC2(1), GANC(1), HK1(3), HK3(1), HSD3B7(1), LCT(2), MGAM(3), PFKL(1), PGM3(1)	16696536	17	16	17	6	8	5	0	3	1	0	0.388	1.000	1.000
470	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(2), CALCR(1), CD97(1), ELTD1(1), EMR1(1), EMR2(1), GIPR(1), GLP2R(1), GPR64(2), LPHN2(2), LPHN3(3), SCTR(1)	11524661	17	15	17	8	3	6	1	6	1	0	0.796	1.000	1.000
471	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(1), FOS(1), IL2RB(2), JAK3(1), MAPK8(1), RAF1(1), SHC1(1), STAT5B(1)	10086593	9	9	9	5	0	4	0	4	1	0	0.817	1.000	1.000
472	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	PIGB(1), PIGS(1), PIGW(1), PIGZ(1)	10254746	4	4	4	3	1	0	0	2	1	0	0.943	1.000	1.000
473	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(3), CASP1(1), MAGI2(2), RERE(4)	10330481	10	10	10	5	3	2	0	4	1	0	0.880	1.000	1.000
474	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	31	CDKN2A(1), PDK1(2), RPS6KA1(1), RPS6KA3(1), SHC1(1), SOS2(1), TEC(1), YWHAE(1), YWHAH(1)	14207631	10	10	10	4	0	0	0	9	1	0	0.905	1.000	1.000
475	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(1), ADC(1), ALDH4A1(1), CAD(2), CPS1(2), EPRS(1), GAD2(1), GFPT1(1), GFPT2(2), GLUD1(2), GLUD2(1), GSS(1), NADSYN1(1)	17016905	17	16	17	6	3	5	0	5	4	0	0.722	1.000	1.000
476	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	BAX(1), CYCS(1), FASLG(1), MAP3K1(2), MDM2(2), NFKBIA(1), PARP1(2), PRF1(1), RIPK1(1), TNF(1), TRADD(1)	15781366	14	14	14	6	3	4	0	4	3	0	0.765	1.000	1.000
477	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	23	EIF2B4(1), EIF2S2(1), FLT4(1), KDR(4), NOS3(3), PLCG1(4), PRKCA(1), SHC1(1)	13042873	16	15	15	7	6	5	0	3	2	0	0.661	1.000	1.000
478	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(1), ARHGDIB(1), BAG4(1), CRADD(1), CYCS(1), LMNA(1), LMNB2(1), MAP3K1(2), MAP3K5(2), MAPK8(1), MDM2(2), NFKBIA(1), NUMA1(3), PRKDC(3), RASA1(2), RB1(3), RIPK1(1), SPTAN1(2), TNF(1), TRADD(1)	29726062	31	27	31	7	7	9	1	7	7	0	0.197	1.000	1.000
479	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AP2M1(1), EEA1(1), PFKL(1), PLCG1(4)	10751892	7	7	6	4	2	3	0	1	1	0	0.852	1.000	1.000
480	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	CREBBP(4), GTF2E1(1), HDAC2(3), HDAC4(2), HDAC5(1), HDAC6(2), NCOR2(3), POLR2A(1)	19982093	17	17	17	8	7	2	0	2	6	0	0.902	1.000	1.000
481	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	63	CCNA1(2), CCNB1(1), CCNE2(1), CCNG2(1), CDKN1B(1), CDKN2A(1), CDKN2C(1), CREB3(3), MCM6(1), MCM7(1), MDM2(2), MYT1(2), POLE(1), PRIM1(1), RB1(3), RPA1(1), TNXB(4), WEE1(1)	32896034	28	26	28	7	4	6	0	4	14	0	0.506	1.000	1.000
482	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG13(1), ALG14(1), ALG5(1), ALG6(1), DAD1(1), DHDDS(1), FUT8(1), GANAB(2), MAN2A1(1), MGAT2(1), MGAT3(2), MGAT5(1), MGAT5B(1), STT3B(2)	18273572	17	16	17	5	3	4	1	5	4	0	0.602	1.000	1.000
483	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	CLOCK(1), ETV6(2), HSPA8(2), IDI1(1), NCKAP1(2), NCOA4(2), PER1(2), PER2(1), SF3A3(1), TUBB3(1)	15750114	15	15	15	6	3	4	0	5	3	0	0.764	1.000	1.000
484	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	FBP2(1), G6PC(3), GANAB(2), HK1(3), HK3(1), LCT(2), MGAM(3), PGM3(1)	14071914	16	15	16	6	8	4	0	3	1	0	0.462	1.000	1.000
485	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	37	BCR(1), DAG1(1), MAPK1(1), NFAT5(2), NFKBIA(1), PI3(1), PLCG2(4), RAF1(1), SHC1(1), SOS2(1), VAV1(3)	21108280	17	16	17	5	5	4	0	5	3	0	0.391	1.000	1.000
486	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	CTCFL(1), DOT1L(1), EHMT1(1), EHMT2(1), EZH1(1), FBXO11(1), HCFC1(2), JMJD6(1), KDM6A(1), MEN1(1), MLL(4), MLL2(9), MLL3(5), MLL5(2), OGT(5), PPP1CB(1), PRDM2(2), PRDM9(4), PRMT5(2), PRMT8(1), SATB1(1), SETD2(4), SETD8(1), SETMAR(2), STK38(1), SUV39H1(1), SUV420H1(1), SUZ12(1)	51182218	58	51	58	11	10	14	2	16	16	0	0.0753	1.000	1.000
487	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTN3(1), SPTAN1(2), TLN1(3)	12318025	6	6	6	4	2	0	0	3	1	0	0.922	1.000	1.000
488	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(2), ATP4A(3), ATP6V0A2(1), ATP6V1C2(1), ATP6V1D(1), COX7B(1), NDUFA3(1), NDUFS1(1), NDUFS3(1), NDUFV2(1), SDHA(3), SDHC(1), TCIRG1(1), UQCRC1(1), UQCRH(1)	24042366	20	17	19	6	7	5	0	3	5	0	0.573	1.000	1.000
489	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(3), ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A3(1), ALDH3A1(3), ALDH3B2(1), AOX1(2), DBH(1), DDC(1), HGD(2), TAT(1), TH(1), TPO(3), TYR(2)	13673039	26	25	26	10	9	5	2	6	4	0	0.503	1.000	1.000
490	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	IL4R(1), IRS1(2), JAK3(1), MAPK1(1), PDK1(2), RAF1(1), SHC1(1), SOS2(1), STAT6(2)	14150253	12	11	12	7	2	2	0	6	2	0	0.895	1.000	1.000
491	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	62	ATR(1), BAI1(1), BAX(1), CCNB1(1), CCNB2(1), CCNB3(1), CCNE2(1), CCNG2(1), CDKN2A(1), CHEK2(1), CYCS(1), DDB2(1), GTSE1(1), MDM2(2), MDM4(1), RFWD2(2), SESN3(1), SIAH1(1), THBS1(1), TSC2(2), ZMAT3(1)	27429788	24	24	24	7	4	7	0	7	6	0	0.428	1.000	1.000
492	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDHPPT(1), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), DOT1L(1), ECHS1(1), EHMT1(1), EHMT2(1), HADHA(2), PLOD1(1)	15982905	16	14	16	8	5	3	0	3	5	0	0.706	1.000	1.000
493	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	23	EGF(3), MAPK1(1), MYLK(1), PRKACG(1), PRKAR1A(2), TLN1(3)	12976640	11	11	11	8	4	2	0	4	1	0	0.975	1.000	1.000
494	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	91	ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADCY9(2), EGF(3), GJA1(1), GNAI1(3), GNAS(3), GRM5(1), GUCY1A3(1), GUCY2C(2), GUCY2F(2), HTR2A(1), HTR2B(2), ITPR1(2), ITPR2(4), ITPR3(4), KRAS(1), MAP2K5(1), MAPK1(1), MAPK7(3), NRAS(1), PDGFA(1), PDGFC(1), PDGFD(1), PDGFRA(7), PLCB1(2), PLCB2(3), PLCB4(1), PRKACG(1), PRKCA(1), PRKCG(1), PRKG2(1), RAF1(1), SOS2(1), TJP1(3), TUBA3C(2), TUBA3D(1), TUBB3(1), TUBB6(1), TUBB8(1)	55901821	77	63	77	17	24	16	2	17	18	0	0.0511	1.000	1.000
495	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(1), ACADS(2), ACADVL(1), ACAT2(1), ACOX3(1), ACSL1(3), ACSL4(1), ACSL6(1), ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), CYP4A11(1), CYP4A22(1), ECHS1(1), HADHA(2), HSD17B4(2)	21087760	30	28	30	10	8	5	0	7	10	0	0.492	1.000	1.000
496	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	BAX(1), CASP1(1), CRADD(1), CYCS(1), FASLG(1), IKBKE(2), NFKBIA(1), NR3C1(1), RIPK1(1), TNF(1), TRADD(1)	18716575	12	12	12	8	4	2	0	3	3	0	0.941	1.000	1.000
497	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	74	ACTB(1), ACTG1(1), ACTN3(1), ACTN4(1), ACVR1C(1), CDH1(1), CREBBP(4), CSNK2A1(1), CTNNA2(1), CTNNA3(1), CTNNB1(1), ERBB2(1), FARP2(1), IGF1R(2), IQGAP1(2), LMO7(1), MAPK1(1), MET(4), MLLT4(1), PTPRB(2), PTPRF(2), PTPRJ(2), PTPRM(2), PVRL3(1), RAC2(1), SMAD2(1), SMAD3(1), TCF7L2(2), TGFBR1(1), TGFBR2(1), TJP1(3), VCL(1), WAS(2), WASF3(2), YES1(1)	50469739	52	49	52	10	15	15	1	9	12	0	0.0221	1.000	1.000
498	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDT1(1), DIAPH2(1), MCM10(1), MCM6(1), MCM7(1), POLD1(1), POLE(1), PRIM1(1), RFC1(1), RPA1(1), UBC(2)	21782990	12	9	12	7	3	2	0	2	5	0	0.947	1.000	1.000
499	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(2), CANT1(3), CTPS2(1), DCTD(1), DHODH(1), DPYS(2), NT5C(2), NT5E(1), POLD1(1), POLE(1), POLQ(2), POLR2A(1), POLR2B(1), POLR2G(1), RRM1(1), TK2(1), UCK1(1), UMPS(1)	24720875	24	23	24	9	7	7	2	2	6	0	0.662	1.000	1.000
500	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	GTF2E1(1), GTF2H4(1), POLR1A(1), POLR2A(1), POLR2B(1), POLR2G(1), POLR3B(1), POLR3D(1), POLR3K(1), TAF6(1)	15095612	10	10	10	9	3	4	1	1	1	0	0.974	1.000	1.000
501	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	82	CD1B(2), CD1E(2), CD22(2), CD36(1), CD44(2), CR1(3), CR2(2), CSF2RA(3), DNTT(1), FCGR1A(1), HLA-DRA(1), HLA-DRB5(2), IL1R1(1), IL1R2(1), IL4R(1), IL6(1), IL7R(1), IL9R(2), ITGA2(1), ITGA2B(1), ITGA4(1), ITGA5(1), KIT(2), MS4A1(1), TFRC(2), TNF(1), TPO(3)	35076777	42	37	42	12	11	15	1	11	4	0	0.147	1.000	1.000
502	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(2), C3(6), C4BPA(1), C4BPB(1), C6(1), C7(2), C8A(2), C8B(1), CD46(1), CFH(4), CR1(3), CR2(2), F13A1(2), F13B(1), F2(3), F5(4), F7(1), F8(3), FGA(1), FGB(1), FGG(1), KLKB1(3), MBL2(2), PROS1(1), SERPING1(2), VWF(3)	38953548	54	48	54	15	19	15	1	8	11	0	0.127	1.000	1.000
503	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	32	FOS(1), IL2RB(2), IRS1(2), JAK3(1), MAPK1(1), RAF1(1), SHC1(1), STAT5B(1)	13984653	10	10	10	8	1	4	0	4	1	0	0.956	1.000	1.000
504	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(1), CAD(2), CANT1(3), CTPS2(1), DCTD(1), DHODH(1), DPYS(2), ENTPD5(1), ENTPD6(1), NT5C(2), NT5E(1), POLA1(2), POLD1(1), POLE(1), POLR1A(1), POLR2A(1), POLR2B(1), POLR2G(1), POLR3A(3), POLR3B(1), POLR3GL(1), POLR3K(1), PRIM1(1), PRIM2(2), RRM1(1), TK2(1), TXNRD2(1), UCK1(1), UMPS(1), UPRT(1)	34838967	39	38	39	10	6	11	4	7	11	0	0.308	1.000	1.000
505	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	67	KDR(4), KRAS(1), MAPK1(1), MAPK12(1), NFAT5(2), NFATC1(1), NFATC2(2), NFATC4(1), NOS3(3), NRAS(1), PIK3CG(2), PIK3R5(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PLCG1(4), PLCG2(4), PPP3R2(1), PRKCA(1), PRKCG(1), PTGS2(1), RAC2(1), RAF1(1), SH2D2A(1)	29486504	42	37	41	12	13	13	1	9	6	0	0.166	1.000	1.000
506	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	ABO(1), B3GNT3(1), B3GNT4(1), B3GNT5(2), B4GALNT1(1), FUT5(1), PIGB(1), PIGS(1), PIGZ(1), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1), ST3GAL6(1), ST6GALNAC3(1), ST8SIA5(1)	20939560	16	16	16	7	4	3	1	5	3	0	0.775	1.000	1.000
507	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(1), BRAF(3), FOS(1), MAP2K3(1), MAP2K5(1), MAP2K6(1), MAP3K1(2), MAP3K10(1), MAP3K12(2), MAP3K13(1), MAP3K4(2), MAP3K5(2), MAP4K4(1), MAPK1(1), MAPK12(1), MAPK4(1), MAPK7(3), MAPK8(1), MAPK9(1), MAPKAPK5(2), MAX(3), MKNK1(1), NFKBIA(1), PAK1(1), RAF1(1), RIPK1(1), RPS6KA1(1), RPS6KA3(1), SHC1(1), TGFBR1(1), TRADD(1)	41061360	42	38	41	10	7	14	0	10	11	0	0.208	1.000	1.000
508	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	82	ABL2(1), BRAF(3), BTC(1), CBLB(1), CBLC(1), CDKN1B(1), EGF(3), ERBB2(1), ERBB3(1), ERBB4(1), HBEGF(1), KRAS(1), MAPK1(1), MAPK8(1), MAPK9(1), NCK1(1), NRAS(1), NRG1(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PIK3CG(2), PIK3R5(1), PLCG1(4), PLCG2(4), PRKCA(1), PRKCG(1), RAF1(1), SHC1(1), SOS2(1), STAT5B(1)	41686649	43	41	42	10	11	10	1	13	8	0	0.174	1.000	1.000
509	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP6(1), ARPC1B(1), CFL1(1), DIAPH1(2), LIMK1(3), MYLK(1), OPHN1(2), TLN1(3), VCL(1)	19549533	15	15	15	6	4	3	0	6	2	0	0.709	1.000	1.000
510	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(3), ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A3(1), ALDH3A1(3), ALDH3B2(1), AOX1(2), DBH(1), DDC(1), ESCO2(1), HGD(2), PRMT5(2), PRMT8(1), TAT(1), TH(1), TPO(3), TYR(2), TYRP1(2)	25611800	32	29	32	10	9	8	3	6	6	0	0.345	1.000	1.000
511	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	FBP2(1), GMDS(1), HK1(3), HK3(1), HSD3B7(1), MTMR6(1), PFKL(1), TSTA3(1)	16074771	10	10	10	5	3	5	0	1	1	0	0.675	1.000	1.000
512	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	AR(1), ESR2(2), NR1H3(1), NR3C1(1), NR4A1(1), NR5A2(1), PPARG(1), RXRA(1), RXRG(3), THRA(1)	18191302	13	11	13	8	4	3	1	3	2	0	0.948	1.000	1.000
513	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	44	BCR(1), CD22(2), CR2(2), DAG1(1), FLOT1(1), FLOT2(2), ITPR1(2), ITPR2(4), ITPR3(4), MAPK1(1), NFATC1(1), NFATC2(2), PDK1(2), PLCG2(4), PTPRC(3), RAF1(1), SHC1(1), SOS2(1), VAV1(3)	30249701	38	35	38	12	13	9	1	13	2	0	0.349	1.000	1.000
514	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	89	CARD11(3), CBLB(1), CBLC(1), CD28(1), CTLA4(1), FOS(1), KRAS(1), LAT(1), NCK1(1), NFAT5(2), NFATC1(1), NFATC2(2), NFATC4(1), NFKBIA(1), NRAS(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PDK1(2), PIK3CG(2), PIK3R5(1), PLCG1(4), PPP3R2(1), PRKCQ(1), PTPRC(3), SOS2(1), TEC(1), TNF(1), VAV1(3), ZAP70(2)	41353947	45	39	44	11	14	13	1	11	6	0	0.102	1.000	1.000
515	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	DLG4(1), LPA(1), MAP3K1(2), MAP3K5(2), MAPK8(1), NFKBIA(1), PDK1(2), PHKA2(2), PI3(1), PLD1(3), RDX(1), ROCK2(1), SRF(1)	21109372	19	19	19	7	3	4	2	8	2	0	0.749	1.000	1.000
516	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	BAX(1), CASP1(1), CYCS(1), FASLG(1), MAP3K1(2), MDM2(2), NFKBIA(1), PLEKHG5(1), PRF1(1), RIPK1(1), TNF(1), TRADD(1)	24376500	14	14	14	9	4	3	0	4	3	0	0.947	1.000	1.000
517	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(1), CTNNB1(1), DVL2(1), FZD10(1), FZD5(1), FZD6(1), FZD7(1), FZD9(1), MAPK9(1), PAFAH1B1(2), PPP2R5E(1), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(1), WNT11(2), WNT16(1), WNT2(1), WNT7A(1)	25956401	21	20	21	8	10	2	0	4	5	0	0.617	1.000	1.000
518	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(1), BRAF(3), CALML3(1), CREBBP(4), GRIA1(5), GRIN1(1), GRIN2A(3), GRIN2B(3), GRIN2C(2), GRIN2D(2), GRM5(1), ITPR1(2), ITPR2(4), ITPR3(4), KRAS(1), MAPK1(1), NRAS(1), PLCB1(2), PLCB2(3), PLCB4(1), PPP1CB(1), PPP3R2(1), PRKACG(1), PRKCA(1), PRKCG(1), RAF1(1), RPS6KA1(1), RPS6KA3(1), RPS6KA6(1)	42943445	54	52	54	16	14	12	3	18	7	0	0.329	1.000	1.000
519	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	76	ANGPTL2(1), ARHGEF6(2), BRAF(3), CDKN2A(1), DOCK1(1), GRB7(1), ITGA10(1), ITGA11(2), ITGA2(1), ITGA4(1), ITGA5(1), ITGA8(1), MAPK1(1), MAPK8(1), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1), MYLK(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PKLR(1), PLCG1(4), PLCG2(4), RAF1(1), RALA(1), ROCK2(1), SHC1(1), SOS2(1), TLN1(3), TLN2(1), WAS(2)	51432792	46	41	45	10	11	10	1	15	9	0	0.129	1.000	1.000
520	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASDHPPT(1), ACAT2(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), DOT1L(1), ECHS1(1), EHMT1(1), EHMT2(1), HADHA(2), HSD17B4(2), HSD3B7(1), OGDHL(1), PLOD1(1), SUV39H1(1)	25064303	21	19	21	8	7	2	0	6	6	0	0.612	1.000	1.000
521	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADCY9(2), CALML3(1), CREB3(3), CREBBP(4), CTNNB1(1), DVL2(1), FZD10(1), FZD5(1), FZD6(1), FZD7(1), FZD9(1), GNAI1(3), GNAO1(3), GNAS(3), KIT(2), KRAS(1), MAPK1(1), NRAS(1), PLCB1(2), PLCB2(3), PLCB4(1), PRKACG(1), PRKCA(1), PRKCG(1), RAF1(1), TCF7L2(2), TYR(2), TYRP1(2), WNT11(2), WNT16(1), WNT2(1), WNT7A(1), WNT8A(1), WNT9B(1)	47099701	62	54	62	16	24	7	0	15	16	0	0.220	1.000	1.000
522	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	42	CREBBP(4), DTX1(1), DVL2(1), HDAC2(3), MAML1(2), MAML2(2), MFNG(1), NCOR2(3), NCSTN(1), NOTCH2(5), NOTCH3(4), NOTCH4(5), NUMBL(2), RBPJ(4), RBPJL(1)	28211878	39	36	39	13	10	6	1	6	15	1	0.698	1.000	1.000
523	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(1), IL6ST(2), RPL23(1), RPL7(1), RPL7A(1), RPS2(1), RPS24(1), RPS4X(1), RPS6KA1(1), RPS6KA3(1), RPS6KA6(1), SLC36A2(1), UBC(2)	22538352	15	15	15	6	0	4	1	8	2	0	0.832	1.000	1.000
524	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	ABP1(3), ACAT2(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), AOX1(2), CYP1A2(2), DDC(1), ECHS1(1), HADHA(2), HSD17B4(2), LNX1(1), NFX1(1), OGDHL(1), PRMT5(2), PRMT8(1), TDO2(1), WARS2(1)	26107442	29	28	29	10	11	9	1	4	4	0	0.380	1.000	1.000
525	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTN3(1), BCR(1), MAPK1(1), MAPK8(1), RAF1(1), SHC1(1), TLN1(3), VCL(1)	20351425	10	10	10	6	1	3	0	5	1	0	0.914	1.000	1.000
526	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	ALG13(1), ALG14(1), ALG6(1), B3GNT7(1), C1GALT1(1), CHPF(1), CHST1(1), CHST11(1), CHST13(1), CHSY1(1), DAD1(1), EXT1(1), EXT2(1), EXTL1(2), FUT8(1), GALNT1(1), GALNT14(1), GALNT4(1), GALNT5(1), GALNT6(1), GALNTL1(1), GALNTL4(1), GALNTL5(1), GANAB(2), HS3ST3A1(1), HS6ST2(2), MAN2A1(1), MGAT2(1), MGAT3(2), MGAT5(1), MGAT5B(1), NDST2(1), NDST3(2), OGT(5), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1), ST6GALNAC1(1), STT3B(2), WBSCR17(4), XYLT1(2)	47592682	55	48	55	14	17	12	3	14	9	0	0.205	1.000	1.000
527	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	65	AGTR2(1), ATP8A1(1), AVPR1A(2), BRS3(1), CCR10(1), CCR7(1), CXCR4(1), FPR1(1), FSHR(1), GALR1(1), GNRHR(1), GRPR(3), MC3R(1), MC4R(1), MC5R(1), NMBR(2), NPY1R(1), NPY2R(1), OPRD1(1), PPYR1(1), SSTR2(1), SSTR3(2), TACR2(2), TACR3(1), TSHR(2)	22261386	32	29	32	13	12	9	1	8	2	0	0.480	1.000	1.000
528	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	70	CALML3(1), DGKA(1), DGKD(2), DGKH(1), DGKQ(1), FN3K(1), INPP4B(1), INPPL1(1), ITPR1(2), ITPR2(4), ITPR3(4), OCRL(2), PI4KA(2), PI4KB(2), PIK3C2B(1), PIK3CG(2), PIK3R5(1), PIP4K2B(1), PIP4K2C(2), PLCB1(2), PLCB2(3), PLCB4(1), PLCD3(2), PLCE1(3), PLCG1(4), PLCG2(4), PLCZ1(1), PRKCA(1), PRKCG(1), PTPMT1(1), SYNJ1(1), SYNJ2(3)	51754544	59	56	58	15	19	15	2	13	10	0	0.200	1.000	1.000
529	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	DARS2(1), EPRS(1), FARS2(2), GARS(1), HARS(1), IARS2(1), LARS(1), MARS2(1), RARS(1), RARS2(2), WARS2(1)	23363114	13	12	13	8	1	7	0	4	1	0	0.932	1.000	1.000
530	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1C(1), ACVR2A(2), ACVRL1(2), BMP4(2), BMPR1B(1), CREBBP(4), CUL1(1), DCN(1), GDF6(1), LEFTY2(1), LTBP1(1), MAPK1(1), PITX2(1), PPP2R2C(1), ROCK2(1), SMAD1(1), SMAD2(1), SMAD3(1), SMAD5(1), SMAD6(1), SMAD9(1), SMURF2(1), TGFBR1(1), TGFBR2(1), THBS1(1), THBS2(1), THBS4(1), TNF(1)	42787774	34	31	34	10	11	10	2	6	5	0	0.253	1.000	1.000
531	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	41	ANGPTL2(1), CFL1(1), GDI1(2), INPPL1(1), ITPR1(2), ITPR2(4), ITPR3(4), LIMK1(3), MYLK(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PDK1(2), PIK3CG(2), PITX2(1), ROCK2(1), RPS4X(1), SAG(1)	28233139	31	29	31	11	6	10	2	11	2	0	0.584	1.000	1.000
532	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	96	CXCL9(1), FOS(1), IFNA21(1), IFNA5(1), IFNAR1(2), IKBKE(2), IL12B(1), IL6(1), IRAK4(1), LBP(1), MAP2K3(1), MAP2K6(1), MAPK1(1), MAPK12(1), MAPK8(1), MAPK9(1), NFKBIA(1), PIK3CG(2), PIK3R5(1), RIPK1(1), SPP1(1), TBK1(1), TICAM1(1), TLR1(3), TLR2(1), TLR3(1), TLR5(1), TLR6(2), TLR7(2), TLR9(2), TNF(1), TOLLIP(1)	37068563	40	39	40	14	10	13	2	9	6	0	0.430	1.000	1.000
533	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADCY9(2), ADRA1B(1), ADRB2(1), ANXA6(1), ARRB2(1), ATP2B2(1), ATP2B3(3), CACNA1A(2), CACNA1B(4), CACNA1D(1), CACNA1E(6), CACNA1S(5), CACNB3(1), CALR(1), CASQ2(1), CHRM1(1), CHRM3(3), CHRM5(1), GJA1(1), GJB2(1), GJB6(1), GNAO1(3), GNB2(1), GNG12(1), GRK4(1), ITPR1(2), ITPR2(4), ITPR3(4), KCNB1(3), MYCBP(1), PEA15(1), PRKAR1A(2), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(1), RGS19(1), RGS3(4), RGS6(1), RGS9(1), RYR1(7), RYR2(10), RYR3(3), SLC8A3(2), YWHAH(1)	80909542	104	75	103	28	34	23	4	24	19	0	0.106	1.000	1.000
534	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(3), AMY2B(1), DDX4(2), DDX51(2), DDX52(1), DDX55(1), DDX56(1), ENPP1(1), ENPP3(2), G6PC(3), G6PC2(1), GANC(1), HK1(3), HK3(1), IFIH1(2), MGAM(3), MOV10L1(1), PGM3(1), PYGB(1), PYGL(1), RAD54L(1), RUVBL2(1), SETX(3), SI(4), SKIV2L2(1), UGT1A1(3), UGT2A3(1), UGT2B10(4), UGT2B11(3), UGT2B28(2), UGT2B4(1), UGT2B7(1), UXS1(2)	53282909	59	52	59	17	17	18	0	17	7	0	0.231	1.000	1.000
535	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVRL1(2), BUB1(1), CLK1(1), CLK4(1), CSNK2A1(1), DGKA(1), DGKD(2), DGKH(1), DGKQ(1), INPP4B(1), INPPL1(1), MAP3K10(1), OCRL(2), PAK4(1), PIK3C2B(1), PIK3CG(2), PLCB1(2), PLCB2(3), PLCB4(1), PLCG1(4), PLCG2(4), PRKACG(1), PRKAR1A(2), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(1), RAF1(1), RPS6KA1(1), RPS6KA3(1), TGFBR1(1), VRK1(2)	47688977	47	42	46	14	14	15	1	11	6	0	0.349	1.000	1.000
536	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	122	BRAF(3), CD244(1), FASLG(1), HLA-G(2), ICAM1(1), IFNA21(1), IFNA5(1), IFNAR1(2), IFNGR2(1), ITGAL(2), ITGB2(1), KIR2DL1(3), KLRC2(1), KRAS(1), LAT(1), MAPK1(1), MICA(1), NFAT5(2), NFATC1(1), NFATC2(2), NFATC4(1), NRAS(1), PAK1(1), PIK3CG(2), PIK3R5(1), PLCG1(4), PLCG2(4), PPP3R2(1), PRF1(1), PRKCA(1), PRKCG(1), PTK2B(1), RAC2(1), RAF1(1), SH2D1A(1), SH2D1B(1), SH3BP2(1), SHC1(1), SOS2(1), TNF(1), TNFRSF10C(1), ULBP1(1), VAV1(3), ZAP70(2)	45981770	63	57	62	23	18	18	1	16	10	0	0.451	1.000	1.000
537	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	187	ACTB(1), ACTG1(1), ACTN3(1), ACTN4(1), BRAF(3), COL11A1(1), COL1A2(5), COL2A1(1), COL3A1(3), COL4A1(1), COL4A4(1), COL4A6(3), COL5A1(1), COL5A2(1), COL6A3(6), COL6A6(1), CTNNB1(1), DIAPH1(2), DOCK1(1), EGF(3), ERBB2(1), FARP2(1), FLNA(3), FLNB(4), FLNC(4), HGF(2), IBSP(1), IGF1R(2), ITGA10(1), ITGA11(2), ITGA2(1), ITGA2B(1), ITGA4(1), ITGA5(1), ITGA8(1), ITGB6(1), ITGB7(1), ITGB8(1), KDR(4), LAMA1(3), LAMA2(3), LAMA3(8), LAMA4(1), LAMA5(5), LAMB1(1), LAMB4(3), LAMC1(1), LAMC2(1), LAMC3(2), MAPK1(1), MAPK8(1), MAPK9(1), MET(4), MYLK(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PARVB(1), PDGFA(1), PDGFC(1), PDGFD(1), PDGFRA(7), PGF(1), PIK3CG(2), PIK3R5(1), PPP1CB(1), PRKCA(1), PRKCG(1), RAC2(1), RAF1(1), RAPGEF1(2), RELN(4), ROCK2(1), SHC1(1), SOS2(1), SPP1(1), THBS1(1), THBS2(1), THBS4(1), TLN1(3), TLN2(1), TNC(2), TNN(2), TNR(1), TNXB(4), VAV1(3), VCL(1), VEGFB(2), VEGFC(2), VWF(3)	156268470	168	122	167	60	54	46	5	39	24	0	0.267	1.000	1.000
538	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	167	ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY7(1), ADCY9(2), ADRA1B(1), ADRB2(1), ATP2B2(1), ATP2B3(3), AVPR1A(2), CACNA1A(2), CACNA1B(4), CACNA1D(1), CACNA1E(6), CACNA1F(3), CACNA1G(1), CACNA1H(2), CACNA1I(1), CACNA1S(5), CALML3(1), CHRM1(1), CHRM3(3), CHRM5(1), ERBB2(1), ERBB3(1), ERBB4(1), GNAS(3), GRIN1(1), GRIN2A(3), GRIN2C(2), GRIN2D(2), GRM5(1), GRPR(3), HRH1(1), HTR2A(1), HTR2B(2), HTR4(1), HTR5A(1), ITPR1(2), ITPR2(4), ITPR3(4), MYLK(1), NOS1(1), NOS3(3), P2RX1(1), P2RX2(1), P2RX3(1), P2RX4(1), PDE1A(1), PDE1B(1), PDE1C(1), PDGFRA(7), PHKA2(2), PHKB(1), PLCB1(2), PLCB2(3), PLCB4(1), PLCD3(2), PLCE1(3), PLCG1(4), PLCG2(4), PLCZ1(1), PPP3R2(1), PRKACG(1), PRKCA(1), PRKCG(1), PTAFR(1), PTK2B(1), RYR1(7), RYR2(10), RYR3(3), SLC25A5(1), SLC8A3(2), TACR2(2), TACR3(1), VDAC3(2)	115150283	158	114	157	50	49	41	4	34	30	0	0.228	1.000	1.000
539	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	235	ADCYAP1R1(2), ADRA1B(1), ADRB2(1), AGTR2(1), AVPR1A(2), BRS3(1), CALCR(1), CHRM1(1), CHRM3(3), CHRM5(1), CTSG(1), DRD5(3), F2(3), F2RL1(2), FPR1(1), FSHR(1), GABRA1(3), GABRA3(2), GABRA4(3), GABRA5(1), GABRA6(3), GABRB1(2), GABRB2(2), GABRB3(1), GABRE(2), GABRG2(1), GABRG3(1), GABRP(1), GALR1(1), GH1(1), GHR(1), GIPR(1), GLP2R(1), GLRA1(1), GLRB(1), GNRHR(1), GPR156(1), GPR35(1), GPR50(2), GPR83(1), GRIA1(5), GRIA3(4), GRID2(1), GRIK2(1), GRIK4(1), GRIN1(1), GRIN2A(3), GRIN2B(3), GRIN2C(2), GRIN2D(2), GRIN3A(1), GRM3(1), GRM4(3), GRM5(1), GRM6(2), GRM7(2), GRPR(3), HCRTR2(1), HRH1(1), HRH4(1), HTR1B(2), HTR1E(1), HTR2A(1), HTR2B(2), HTR4(1), HTR5A(1), MC3R(1), MC4R(1), MC5R(1), MCHR2(1), MTNR1A(1), NMBR(2), NMUR2(1), NPY1R(1), NPY2R(1), NR3C1(1), OPRD1(1), P2RX1(1), P2RX2(1), P2RX3(1), P2RX4(1), P2RY2(1), P2RY6(1), PPYR1(1), PTAFR(1), PTH2R(1), RXFP2(2), SCTR(1), SSTR2(1), SSTR3(2), TAAR5(1), TACR2(2), TACR3(1), THRA(1), TSHR(2), UTS2R(1)	95356142	142	108	142	46	54	34	2	33	19	0	0.108	1.000	1.000
540	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	244	ACVR1C(1), ARRB2(1), ATF2(1), BRAF(3), CACNA1A(2), CACNA1B(4), CACNA1D(1), CACNA1E(6), CACNA1F(3), CACNA1G(1), CACNA1H(2), CACNA1I(1), CACNA1S(5), CACNA2D3(1), CACNA2D4(1), CACNB2(1), CACNB3(1), CACNG3(3), CACNG7(1), CACNG8(1), CDC25B(1), DDIT3(1), DUSP16(1), DUSP5(2), EGF(3), FASLG(1), FGF4(1), FGF5(2), FGF6(1), FGF7(1), FGFR2(1), FGFR4(1), FLNA(3), FLNB(4), FLNC(4), FOS(1), GNG12(1), IL1R1(1), IL1R2(1), KRAS(1), MAP2K3(1), MAP2K5(1), MAP2K6(1), MAP3K1(2), MAP3K10(1), MAP3K12(2), MAP3K13(1), MAP3K4(2), MAP3K5(2), MAP4K4(1), MAPK1(1), MAPK12(1), MAPK7(3), MAPK8(1), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1), MAPKAPK5(2), MAX(3), MKNK1(1), NFATC2(2), NFATC4(1), NR4A1(1), NRAS(1), PAK1(1), PDGFA(1), PDGFRA(7), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PPM1B(1), PPP3R2(1), PRKACG(1), PRKCA(1), PRKCG(1), PTPN5(1), PTPRR(2), RAC2(1), RAF1(1), RASA1(2), RASGRF2(2), RASGRP2(1), RASGRP4(1), RPS6KA1(1), RPS6KA3(1), RPS6KA6(1), RRAS(1), SOS2(1), SRF(1), STK3(1), TAOK1(2), TGFBR1(1), TGFBR2(1), TNF(1)	119543651	150	106	149	57	35	47	3	32	33	0	0.681	1.000	1.000
541	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(1), ACTG1(1), COL11A1(1), COL17A1(1), COL1A2(5), COL2A1(1), COL3A1(3), COL4A1(1), COL4A4(1), COL4A6(3), COL5A1(1), COL5A2(1), COL6A3(6), COL6A6(1), DSC1(1), DSC2(1), DSC3(2), DSG1(2), DSG2(3), DSG3(2), DSG4(1), GJA1(1), GJA3(1), GJA8(1), GJB2(1), GJB6(1), GJC3(1), IBSP(1), KRT15(2), KRT16(1), KRT17(1), KRT20(3), KRT27(1), KRT28(2), KRT3(3), KRT31(2), KRT33A(2), KRT33B(2), KRT34(1), KRT35(1), KRT36(1), KRT37(2), KRT39(1), KRT6B(1), KRT6C(2), KRT71(1), KRT73(2), KRT75(1), KRT76(1), KRT8(1), KRT83(2), KRT84(1), KRT86(1), KRT9(1), LAMA1(3), LAMA2(3), LAMA3(8), LAMA4(1), LAMA5(5), LAMB1(1), LAMB4(3), LAMC1(1), LAMC2(1), LAMC3(2), LMNA(1), LMNB2(1), NES(1), RELN(4), SPP1(1), THBS1(1), THBS2(1), THBS4(1), TNC(2), TNN(2), TNR(1), TNXB(4), VWF(3)	107479881	136	103	136	53	59	35	3	28	11	0	0.445	1.000	1.000
542	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	199	ACTN3(1), ACTN4(1), APC(1), ARHGEF12(1), ARHGEF4(2), ARHGEF6(2), ARPC1B(1), BRAF(3), CFL1(1), CHRM1(1), CHRM3(3), CHRM5(1), CYFIP2(1), DIAPH1(2), DIAPH2(1), DIAPH3(1), DOCK1(1), EGF(3), F2(3), FGF4(1), FGF5(2), FGF6(1), FGF7(1), FGFR2(1), FGFR4(1), GNG12(1), IQGAP1(2), ITGA10(1), ITGA11(2), ITGA2(1), ITGA2B(1), ITGA4(1), ITGA5(1), ITGA8(1), ITGAD(1), ITGAE(1), ITGAL(2), ITGAX(1), ITGB2(1), ITGB6(1), ITGB7(1), ITGB8(1), KRAS(1), LIMK1(3), MAPK1(1), MYH10(2), MYH14(2), MYLK(1), NCKAP1(2), NCKAP1L(2), NRAS(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PDGFA(1), PDGFRA(7), PFN4(1), PIK3CG(2), PIK3R5(1), PIP4K2B(1), PIP4K2C(2), PPP1CB(1), RAC2(1), RAF1(1), RDX(1), ROCK2(1), RRAS(1), SCIN(1), SOS2(1), SSH1(1), TIAM1(2), TIAM2(2), VAV1(3), VCL(1), WAS(2)	115754655	110	96	110	44	23	27	4	34	22	0	0.791	1.000	1.000
543	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	CD36(1), CD44(2), COL11A1(1), COL1A2(5), COL2A1(1), COL3A1(3), COL4A1(1), COL4A4(1), COL4A6(3), COL5A1(1), COL5A2(1), COL6A3(6), COL6A6(1), DAG1(1), FNDC1(2), FNDC3A(2), HSPG2(6), IBSP(1), ITGA10(1), ITGA11(2), ITGA2(1), ITGA2B(1), ITGA4(1), ITGA5(1), ITGA8(1), ITGB6(1), ITGB7(1), ITGB8(1), LAMA1(3), LAMA2(3), LAMA3(8), LAMA4(1), LAMA5(5), LAMB1(1), LAMB4(3), LAMC1(1), LAMC2(1), LAMC3(2), RELN(4), SDC1(1), SPP1(1), THBS1(1), THBS2(1), THBS4(1), TNC(2), TNN(2), TNR(1), TNXB(4), VWF(3)	96715339	99	80	99	39	38	33	3	17	8	0	0.394	1.000	1.000
544	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	249	ACVR2A(2), BMPR1B(1), CCL20(1), CCR7(1), CD70(1), CNTFR(1), CRLF2(2), CSF2RA(3), CSF2RB(1), CXCL13(1), CXCL9(1), CXCR4(1), EDA(1), EDAR(3), EGF(3), FASLG(1), FLT4(1), GH1(1), GHR(1), HGF(2), IFNA21(1), IFNA5(1), IFNAR1(2), IFNGR2(1), IL12B(1), IL12RB1(1), IL13RA1(1), IL15(1), IL17RA(1), IL18(2), IL19(1), IL1R1(1), IL1R2(1), IL20RA(1), IL22RA1(1), IL23R(1), IL2RB(2), IL4R(1), IL6(1), IL6ST(2), IL7R(1), IL9R(2), KDR(4), KIT(2), LIFR(1), LTBR(2), MET(4), OSMR(1), PDGFC(1), PDGFRA(7), TGFBR1(1), TGFBR2(1), TNF(1), TNFRSF10C(1), TNFRSF13B(1), TNFRSF14(1), TNFRSF6B(1), TNFRSF9(2), TNFSF14(1), TNFSF15(2), TNFSF8(1), TNFSF9(1), TPO(3), VEGFB(2), VEGFC(2), XCL1(1)	75286322	100	77	99	43	20	36	4	24	16	0	0.765	1.000	1.000
545	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABLIM1(2), ABLIM3(2), ARHGEF12(1), CFL1(1), CXCR4(1), DCC(2), EFNB3(1), EPHA3(4), EPHA4(3), EPHA5(3), EPHA6(1), EPHA7(1), EPHA8(1), EPHB6(3), GNAI1(3), KRAS(1), L1CAM(1), LIMK1(3), LRRC4C(1), MAPK1(1), MET(4), NCK1(1), NFAT5(2), NFATC1(1), NFATC2(2), NFATC4(1), NGEF(1), NRAS(1), NTN4(1), NTNG1(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PLXNA1(2), PLXNA2(1), PLXNA3(4), PLXNB1(1), PLXNB3(1), PPP3R2(1), RAC2(1), RASA1(2), RGS3(4), RHOD(1), ROBO1(1), ROBO3(4), ROCK2(1), SEMA3A(1), SEMA3B(1), SEMA3C(1), SEMA3E(1), SEMA3F(1), SEMA4A(1), SEMA4B(1), SEMA4F(1), SEMA6A(1), SEMA6B(2), SEMA6C(1), SEMA6D(2), SEMA7A(1), SLIT1(3), SLIT2(3), SLIT3(1), SRGAP1(1), SRGAP2(1)	85317113	103	77	101	34	26	28	6	24	19	0	0.337	1.000	1.000
546	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	128	ACTB(1), ACTG1(1), ACTN3(1), ACTN4(1), AMOTL1(3), CASK(1), CLDN11(1), CLDN14(1), CLDN16(1), CLDN19(1), CSNK2A1(1), CTNNA2(1), CTNNA3(1), CTNNB1(1), CTTN(1), EPB41L1(1), EPB41L2(2), EPB41L3(2), EXOC4(2), GNAI1(3), HCLS1(1), INADL(1), JAM2(1), KRAS(1), LLGL2(1), MAGI2(2), MAGI3(1), MLLT4(1), MPDZ(3), MYH1(2), MYH10(2), MYH11(4), MYH13(5), MYH14(2), MYH15(5), MYH3(3), MYH6(2), MYH7(1), MYH7B(3), MYH8(6), NRAS(1), PPM1J(1), PPP2R2C(1), PPP2R3A(1), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(1), RAB3B(1), RRAS(1), SPTAN1(2), TJP1(3), YES1(1)	79745392	90	73	90	26	33	19	2	18	18	0	0.184	1.000	1.000
547	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADCY9(2), ADK(1), ADSL(1), ADSSL1(1), AK7(4), AMPD2(2), CANT1(3), ENPP1(1), ENPP3(2), ENTPD5(1), ENTPD6(1), GART(1), GMPR(1), GMPR2(1), GUCY1A3(1), GUCY2C(2), GUCY2F(2), IMPDH2(1), NT5C(2), NT5E(1), PAICS(1), PDE11A(2), PDE1A(1), PDE1C(1), PDE2A(1), PDE4D(1), PDE7B(1), PDE8A(3), PFAS(1), PKLR(1), POLA1(2), POLD1(1), POLE(1), POLR1A(1), POLR2A(1), POLR2B(1), POLR2G(1), POLR3A(3), POLR3B(1), POLR3GL(1), POLR3K(1), PRIM1(1), PRIM2(2), PRPS1(1), PRPS1L1(1), PRPS2(1), RRM1(1), XDH(2)	70351650	75	66	74	24	28	18	4	12	13	0	0.241	1.000	1.000
548	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	CADM1(1), CD22(2), CD276(1), CD28(1), CD58(1), CDH1(1), CDH15(1), CDH4(4), CDH5(1), CLDN11(1), CLDN14(1), CLDN16(1), CLDN19(1), CNTN2(2), CNTNAP2(2), CTLA4(1), ESAM(1), HLA-DMB(1), HLA-DOA(1), HLA-DQA2(2), HLA-DRA(1), HLA-DRB5(2), HLA-F(2), HLA-G(2), ICAM1(1), ITGA4(1), ITGA8(1), ITGAL(2), ITGB2(1), ITGB7(1), ITGB8(1), JAM2(1), L1CAM(1), MAG(1), NCAM1(2), NEGR1(2), NEO1(2), NLGN1(1), NLGN2(1), NLGN3(3), NRCAM(2), NRXN1(1), NRXN3(1), PTPRC(3), PTPRF(2), PTPRM(2), PVR(2), PVRL3(1), SDC1(1), SELE(3), SELP(1), SELPLG(1), SIGLEC1(1), VCAN(3)	63752914	80	66	79	35	30	14	3	18	15	0	0.697	1.000	1.000
549	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA2(1), ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADCY9(2), ARRB2(1), ATF2(1), CACNB3(1), CNN2(1), CREB3(3), FOS(1), GJA1(1), GNB2(1), GNG12(1), GRK4(1), GUCY1A3(1), IGFBP2(1), IL6(1), ITPR1(2), ITPR2(4), ITPR3(4), NOS1(1), NOS3(3), PDE4D(1), PLCG1(4), PLCG2(4), PRKAR1A(2), PRKCA(1), PRKCH(1), PRKCQ(1), RGS19(1), RGS3(4), RGS6(1), RGS9(1), RLN1(1), RYR1(7), RYR2(10), RYR3(3), TNXB(4), YWHAH(1)	74679350	87	65	85	29	30	18	3	19	17	0	0.440	1.000	1.000
550	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA2(1), ACTN3(1), ACTN4(1), DMD(4), MYBPC2(2), MYH3(3), MYH6(2), MYH7(1), MYH8(6), MYOM1(1), NEB(10), TNNI1(1), TNNT1(1), TNNT3(2), TPM1(2), TPM2(1), TPM3(1), TTN(34)	58433085	74	60	73	30	31	15	1	19	8	0	0.702	1.000	1.000
551	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADRA1B(1), ADRB2(1), AGTR2(1), AVPR1A(2), BRS3(1), CCR10(1), CCR7(1), CHRM1(1), CHRM3(3), CHRM5(1), CMKLR1(1), CXCR4(1), DRD5(3), F2RL1(2), FPR1(1), FSHR(1), GALR1(1), GPR17(1), GPR174(1), GPR35(1), GPR50(2), GPR83(1), GPR85(1), GPR87(1), GRPR(3), HCRTR2(1), HRH1(1), HTR1B(2), HTR1E(1), HTR2A(1), HTR2B(2), HTR4(1), HTR5A(1), MC3R(1), MC4R(1), MC5R(1), MTNR1A(1), NMBR(2), NMUR2(1), NPY1R(1), NPY2R(1), OPRD1(1), OR10A5(1), OR1C1(2), OR1Q1(1), P2RY12(2), P2RY2(1), P2RY6(1), PPYR1(1), PTAFR(1), SSTR2(1), SSTR3(2)	52225978	67	57	67	32	28	15	1	16	7	0	0.737	1.000	1.000
552	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	143	APC(1), CHD8(2), CREBBP(4), CSNK1A1L(1), CSNK2A1(1), CTNNB1(1), CUL1(1), CXXC4(1), DKK2(2), DVL2(1), FZD10(1), FZD5(1), FZD6(1), FZD7(1), FZD9(1), LRP6(2), MAPK8(1), MAPK9(1), NFAT5(2), NFATC1(1), NFATC2(2), NFATC4(1), NKD2(1), PLCB1(2), PLCB2(3), PLCB4(1), PPP2R2C(1), PPP3R2(1), PRKACG(1), PRKCA(1), PRKCG(1), RAC2(1), ROCK2(1), SENP2(1), SFRP2(1), SIAH1(1), SMAD2(1), SMAD3(1), SOX17(3), TBL1XR1(1), TBL1Y(1), TCF7L2(2), VANGL2(1), WIF1(2), WNT11(2), WNT16(1), WNT2(1), WNT7A(1), WNT8A(1), WNT9B(1)	69471236	66	57	66	18	22	16	0	14	14	0	0.176	1.000	1.000
553	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	129	ACACA(4), ACACB(5), BRAF(3), CALML3(1), CBLB(1), CBLC(1), FASN(1), FBP2(1), FLOT1(1), FLOT2(2), G6PC(3), G6PC2(1), IRS1(2), IRS4(2), KRAS(1), LIPE(1), MAPK1(1), MAPK8(1), MAPK9(1), MKNK1(1), NRAS(1), PCK1(1), PDE3A(1), PFKL(1), PHKA2(2), PHKB(1), PIK3CG(2), PIK3R5(1), PKLR(1), PPARGC1A(1), PPP1CB(1), PPP1R3A(1), PRKAA1(1), PRKACG(1), PRKAR1A(2), PTPRF(2), PYGB(1), PYGL(1), RAF1(1), RAPGEF1(2), SHC1(1), SOS2(1), SREBF1(3), TSC1(1), TSC2(2)	67690423	67	57	67	24	23	20	1	18	5	0	0.406	1.000	1.000
554	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	147	CBLB(1), CBLC(1), CISH(1), CNTFR(1), CREBBP(4), CRLF2(2), CSF2RA(3), CSF2RB(1), GH1(1), GHR(1), IFNA21(1), IFNA5(1), IFNAR1(2), IFNGR2(1), IL12B(1), IL12RB1(1), IL13RA1(1), IL15(1), IL19(1), IL20RA(1), IL22RA1(1), IL23R(1), IL2RB(2), IL4R(1), IL6(1), IL6ST(2), IL7R(1), IL9R(2), JAK2(1), JAK3(1), LIFR(1), OSMR(1), PIAS3(1), PIK3CG(2), PIK3R5(1), PIM1(1), SOCS5(1), SOS2(1), SPRED2(1), SPRY2(1), SPRY4(1), STAT3(1), STAT5B(1), STAT6(2), TPO(3), TYK2(2)	60412150	61	55	61	25	12	14	3	21	11	0	0.783	1.000	1.000
555	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADCY9(2), AKAP3(1), AKAP4(4), AKAP5(1), AKAP6(3), AKAP8(2), AKAP9(4), GNAO1(3), GNB2(1), GNG12(1), ITPR1(2), KRAS(1), NRAS(1), PDE1A(1), PDE1B(1), PDE1C(1), PDE4D(1), PDE7B(1), PDE8A(3), PRKACG(1), PRKAR1A(2), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(1), RRAS(1)	50452271	50	47	50	17	18	8	1	10	13	0	0.536	1.000	1.000
556	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADK(1), ADSL(1), AMPD2(2), CANT1(3), ENPP1(1), ENPP3(2), GART(1), GUCY1A3(1), GUCY2C(2), GUCY2F(2), IMPDH2(1), NT5C(2), NT5E(1), PAICS(1), PDE1A(1), PDE4D(1), PDE6B(3), PDE6C(3), PDE7B(1), PDE8A(3), PFAS(1), PKLR(1), POLD1(1), POLE(1), POLQ(2), POLR2A(1), POLR2B(1), POLR2G(1), PRPS1(1), PRPS1L1(1), PRPS2(1), RRM1(1)	55286989	54	47	54	25	25	15	2	6	6	0	0.768	1.000	1.000
557	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	106	ACTN3(1), ACTN4(1), CDH5(1), CLDN11(1), CLDN14(1), CLDN16(1), CLDN19(1), CTNNA2(1), CTNNA3(1), CTNNB1(1), CXCR4(1), CYBB(1), ESAM(1), GNAI1(3), ICAM1(1), ITGA4(1), ITGAL(2), ITGB2(1), JAM2(1), MAPK12(1), MLLT4(1), MMP9(1), NCF2(1), PIK3CG(2), PIK3R5(1), PLCG1(4), PLCG2(4), PRKCA(1), PRKCG(1), PTK2B(1), RAC2(1), RHOH(1), ROCK2(1), SIPA1(1), VAV1(3), VCL(1)	50723533	48	44	47	23	21	9	2	10	6	0	0.770	1.000	1.000
558	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	108	ANAPC2(1), ANAPC7(1), ATR(1), BUB1(1), BUB3(1), CCNA1(2), CCNB1(1), CCNB2(1), CCNB3(1), CCNE2(1), CDC14B(2), CDC16(1), CDC25B(1), CDKN1B(1), CDKN2A(1), CDKN2C(1), CHEK2(1), CREBBP(4), CUL1(1), FZR1(1), HDAC2(3), MCM6(1), MCM7(1), MDM2(2), PLK1(1), PRKDC(3), RB1(3), SKP2(1), SMAD2(1), SMAD3(1), SMC1B(1), WEE1(1), YWHAE(1), YWHAH(1)	58039629	46	43	46	15	5	14	1	12	14	0	0.764	1.000	1.000
559	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(2), ABCA10(1), ABCA12(1), ABCA13(6), ABCA2(1), ABCA3(1), ABCA4(3), ABCA6(2), ABCA7(4), ABCA8(1), ABCB1(3), ABCB10(2), ABCB4(3), ABCB7(1), ABCC10(3), ABCC12(1), ABCC3(1), ABCC9(1), ABCD2(1), ABCG1(1), ABCG4(2), ABCG5(1), ABCG8(1), CFTR(3)	50811373	46	39	46	25	11	13	3	10	9	0	0.928	1.000	1.000
560	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	89	CAPN11(2), CAPN3(1), DOCK1(1), ITGA10(1), ITGA11(2), ITGA2(1), ITGA2B(1), ITGA4(1), ITGA5(1), ITGA8(1), ITGAD(1), ITGAE(1), ITGAL(2), ITGAX(1), ITGB2(1), ITGB6(1), ITGB7(1), ITGB8(1), MAP2K3(1), MAP2K6(1), MAPK12(1), MAPK4(1), MAPK7(3), PAK1(1), PAK4(1), PAK6(1), RAC2(1), RAPGEF1(2), ROCK2(1), SHC1(1), TLN1(3), VCL(1)	57070379	40	37	40	18	13	7	0	14	6	0	0.825	1.000	1.000
561	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CDC40(1), CLK4(1), COL2A1(1), CPSF2(1), CSTF1(1), CSTF2(1), CSTF3(1), DDIT3(1), DHX16(1), DHX38(2), FUS(1), LOC440563(1), METTL3(1), PAPOLA(1), POLR2A(1), PRPF18(1), PRPF8(2), PSKH1(1), RNGTT(1), SF3A3(1), SF3B1(2), SNRPB(1), SNRPB2(1), SNRPE(1), SNRPN(1), SPOP(2), SRPK2(1), SRRM1(1), TXNL4A(1), U2AF2(2), XRN2(2)	45547694	37	36	37	12	9	11	1	9	7	0	0.585	1.000	1.000
562	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	81	BUB1(1), BUB3(1), CCNA1(2), CCNB1(1), CCNB2(1), CCNB3(1), CCNE2(1), CDC14B(2), CDC25B(1), CDH1(1), CDKN2A(1), CHEK2(1), HDAC2(3), HDAC4(2), HDAC5(1), HDAC6(2), MCM6(1), MCM7(1), MDM2(2), MPEG1(1), PLK1(1), PRKDC(3), RB1(3), SKP2(1), WEE1(1)	46892134	36	35	36	12	6	10	1	9	10	0	0.738	1.000	1.000
563	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	69	ACACB(5), ACSL1(3), ACSL4(1), ACSL6(1), ADIPOR1(1), CD36(1), G6PC(3), G6PC2(1), IRS1(2), IRS4(2), JAK2(1), JAK3(1), MAPK8(1), MAPK9(1), NFKBIA(1), NPY(2), PCK1(1), PPARGC1A(1), PRKAA1(1), PRKCQ(1), RXRA(1), RXRG(3), STAT3(1), TNF(1), TRADD(1), TYK2(2)	35329628	40	34	40	19	14	13	0	8	5	0	0.724	1.000	1.000
564	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	ACTB(1), CABIN1(2), CREBBP(4), CSNK2A1(1), CTLA4(1), FOS(1), GATA4(1), IL6(1), KPNA5(1), MAPK8(1), MAPK9(1), MYF5(1), NFAT5(2), NFATC1(1), NFATC2(2), NFATC4(1), OPRD1(1), PAK1(1), PTPRC(3), SLA(1), SP3(2), TNF(1), TRPV6(3), VAV1(3)	38486936	37	33	37	17	12	11	1	6	7	0	0.736	1.000	1.000
565	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	68	ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), AKR1C3(2), ALDH1A3(1), ALDH3A1(3), ALDH3B2(1), CYP1A2(2), CYP2B6(1), CYP2C8(1), CYP2S1(1), CYP3A4(2), CYP3A7(1), EPHX1(1), UGT1A1(3), UGT2A3(1), UGT2B10(4), UGT2B11(3), UGT2B28(2), UGT2B4(1), UGT2B7(1)	24259699	36	31	36	13	12	4	1	14	5	0	0.600	1.000	1.000
566	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	48	APOA1(1), CD36(1), CREBBP(4), HSD17B4(2), LPL(1), MAPK1(1), NCOA1(1), NCOR1(3), NCOR2(3), NFKBIA(1), NR1H3(1), PDGFA(1), PRKACG(1), PRKAR1A(2), PRKCA(1), PTGS2(1), RB1(3), RXRA(1), STAT5B(1), TNF(1)	25664654	31	30	31	12	6	9	1	6	9	0	0.758	1.000	1.000
567	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACOX3(1), ACSL1(3), ACSL4(1), ACSL6(1), APOA1(1), CD36(1), CYP4A11(1), CYP4A22(1), CYP8B1(1), FADS2(1), GK(1), GK2(3), LPL(1), MMP1(1), NR1H3(1), PCK1(1), PPARG(1), RXRA(1), RXRG(3), SLC27A4(1), UBC(2)	28202668	28	27	28	11	4	12	1	7	4	0	0.571	1.000	1.000
568	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	59	CARD11(3), CD22(2), CR2(2), FOS(1), IFITM1(1), KRAS(1), LILRB3(2), NFAT5(2), NFATC1(1), NFATC2(2), NFATC4(1), NFKBIA(1), NRAS(1), PIK3CG(2), PIK3R5(1), PLCG2(4), PPP3R2(1), RAC2(1), VAV1(3)	29685578	32	26	32	14	14	7	1	6	4	0	0.589	1.000	1.000
569	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP4(2), CSNK1A1L(1), CSNK1G1(1), CSNK1G2(1), GLI1(1), GLI3(1), HHIP(1), LRP2(8), PRKACG(1), PTCH1(1), RAB23(1), SHH(1), STK36(1), SUFU(1), WNT11(2), WNT16(1), WNT2(1), WNT7A(1), WNT8A(1), WNT9B(1)	26321149	29	25	29	14	12	8	1	3	5	0	0.795	1.000	1.000
570	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	53	ABP1(3), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), AOX1(2), CYP1A2(2), CYP2B6(1), CYP2C8(1), CYP3A4(2), CYP3A7(1), CYP4F8(1), DDC(1), ECHS1(1), HADHA(2), TDO2(1), WARS2(1)	23266363	27	25	27	13	12	6	0	5	4	0	0.777	1.000	1.000
571	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPP(4), ALPPL2(2), DDX4(2), DDX51(2), DDX52(1), DDX55(1), DDX56(1), FPGS(2), IFIH1(2), MOV10L1(1), QDPR(1), RAD54L(1), RUVBL2(1), SETX(3), SKIV2L2(1), SPR(1)	27040912	26	24	26	10	9	6	1	5	5	0	0.680	1.000	1.000
572	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	ARSD(1), ARSE(1), CYP11B1(1), HSD3B2(1), PRMT5(2), PRMT8(1), SRD5A1(1), SULT2B1(2), UGT1A1(3), UGT2A3(1), UGT2B10(4), UGT2B11(3), UGT2B28(2), UGT2B4(1), UGT2B7(1)	21639294	25	23	25	10	5	5	1	13	1	0	0.710	1.000	1.000
573	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG1(1), ANGPTL2(1), CFL1(1), FLNA(3), FLNC(4), FSCN3(2), GDI1(2), LIMK1(3), MYLK(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), ROCK2(1), RPS4X(1)	18934861	24	22	24	10	8	7	1	6	2	0	0.580	1.000	1.000
574	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS2(1), CP(1), EPRS(1), FTH1(1), HCCS(2), PPOX(1), UGT1A1(3), UGT2A3(1), UGT2B10(4), UGT2B11(3), UGT2B28(2), UGT2B4(1), UGT2B7(1)	18203707	22	21	22	10	2	7	0	13	0	0	0.843	1.000	1.000
575	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(3), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH4A1(1), ASL(1), CPS1(2), GLUD1(2), NOS1(1), NOS3(3), RARS(1)	19098778	21	20	21	14	8	5	0	3	5	0	0.960	1.000	1.000
576	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	CALR(1), CIITA(1), HLA-DMB(1), HLA-DOA(1), HLA-DQA2(2), HLA-DRA(1), HLA-DRB5(2), HLA-F(2), HLA-G(2), IFNA21(1), IFNA5(1), KIR2DL1(3), KLRC2(1), RFXANK(1)	19913781	20	20	20	10	4	4	2	7	3	0	0.829	1.000	1.000
577	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(3), AGXT2(1), ALAS2(1), DMGDH(1), GARS(1), GLDC(1), PLCB2(3), PLCG1(4), PLCG2(4), PSPH(1)	18166996	20	19	19	10	8	6	0	4	2	0	0.800	1.000	1.000
578	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	77	BAX(1), CSF2RB(1), CYCS(1), FASLG(1), IL1R1(1), IRAK3(1), IRAK4(1), NFKBIA(1), PIK3CG(2), PIK3R5(1), PPP3R2(1), PRKACG(1), PRKAR1A(2), RIPK1(1), TNF(1), TNFRSF10C(1), TRADD(1)	34073124	19	18	19	13	3	5	1	5	5	0	0.988	1.000	1.000
579	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(1), ASL(1), ASS1(1), CPS1(2), EPRS(1), GLUD1(2), GLUD2(1), NOS1(1), NOS3(3), RARS(1), RARS2(2)	15521148	16	15	16	10	3	5	0	5	3	0	0.955	1.000	1.000
580	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(2), GPRC5C(1), GPRC5D(2), GRM3(1), GRM4(3), GRM5(1), GRM7(2)	9051312	12	12	12	8	9	1	0	2	0	0	0.891	1.000	1.000
581	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(3), AGXT2(1), ALAS2(1), DMGDH(1), GARS(1), GLDC(1), HSD3B7(1), PHGDH(2), PSPH(1)	18444475	12	12	12	10	3	3	0	5	1	0	0.973	1.000	1.000
582	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	ARSD(1), ARSE(1), CYP11B1(1), HSD3B2(1), SRD5A1(1), UGT1A1(3), UGT2B4(1)	11786478	9	9	9	5	3	1	0	5	0	0	0.867	1.000	1.000
583	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC2(1), ANAPC7(1), CDC16(1), CUL1(1), FBXW7(1), FZR1(1), SKP2(1), SMURF2(1), UBE2D4(1)	17280108	9	9	9	9	1	4	1	3	0	0	0.993	1.000	1.000
584	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1), DCN(1), FMOD(1), KERA(3), LUM(1)	1563894	7	7	7	5	1	3	0	3	0	0	0.889	1.000	1.000
585	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	34	G6PD(2), GGT1(2), GPX2(1), GSS(1)	8800697	6	6	6	4	3	2	0	1	0	0	0.826	1.000	1.000
586	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	MAPK1(1), PDK1(2), PTK2B(1), SHC1(1)	7498225	5	5	5	3	0	2	0	3	0	0	0.876	1.000	1.000
587	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	ARHGDIB(1), CASP1(1), CYCS(1), PRF1(1)	5538024	4	4	4	3	1	1	0	2	0	0	0.934	1.000	1.000
588	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	MYLK(1), PLCB1(2), PRKCA(1)	8878408	4	4	4	4	2	0	0	2	0	0	0.962	1.000	1.000
589	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(1), POLD1(1), PRPS2(1), RRM1(1)	5384326	4	4	4	3	2	2	0	0	0	0	0.838	1.000	1.000
590	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	RELN(4)	6036684	4	4	4	3	1	3	0	0	0	0	0.833	1.000	1.000
591	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(1), POLE(1), POLQ(2)	7174802	4	3	4	5	4	0	0	0	0	0	0.984	1.000	1.000
592	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(1), EIF2AK4(1), EIF2S2(1)	4956168	3	3	3	3	1	0	1	1	0	0	0.939	1.000	1.000
593	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	CYCS(1), FASLG(1), TNF(1)	4880765	3	3	3	4	0	1	0	2	0	0	0.995	1.000	1.000
594	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	IL6(1), STAT3(1), TNF(1)	5237079	3	3	3	3	1	1	0	1	0	0	0.951	1.000	1.000
595	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR2A(1), POLR2B(1), POLR2G(1)	5833305	3	3	3	3	1	2	0	0	0	0	0.903	1.000	1.000
596	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	DNMT1(1), MTNR1A(1), PTAFR(1)	4823811	3	3	3	3	2	1	0	0	0	0	0.929	1.000	1.000
597	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGEF2(2)	6984804	2	2	2	2	0	1	1	0	0	0	0.907	1.000	1.000
598	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	GPR34(1), GPR45(1)	4225350	2	2	2	3	1	1	0	0	0	0	0.945	1.000	1.000
599	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD58(1), IL6(1)	2654615	2	2	2	2	0	0	0	2	0	0	0.951	1.000	1.000
600	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	HLA-DRA(1), IL6(1)	2299642	2	2	2	2	0	0	0	2	0	0	0.952	1.000	1.000
601	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	MAPK8(1), TNFRSF13B(1)	6273334	2	2	2	2	0	2	0	0	0	0	0.893	1.000	1.000
602	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	14	IL6(1)	3504419	1	1	1	4	0	0	0	1	0	0	0.998	1.000	1.000
603	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	14	IL6(1)	2564187	1	1	1	2	0	0	0	1	0	0	0.979	1.000	1.000
604	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14		4992904	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
605	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9		3754891	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
606	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1		311704	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
607	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		219003	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
608	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4		1325492	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
609	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		656813	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
610	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	1		435392	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
611	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	4		2245719	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
612	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11		3998853	0	0	0	3	0	0	0	0	0	0	1.000	1.000	1.000
613	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3		736382	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
614	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17		3758025	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
615	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7		2628571	0	0	0	2	0	0	0	0	0	0	1.000	1.000	1.000
616	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3		490549	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
