rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(2), ACO1(1), ACSS1(2), IDH1(220), IDH2(12)	5724551	237	235	10	1	210	8	1	17	1	0	<1.00e-15	<1.00e-15	<5.13e-14
2	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(2), ACO1(1), IDH1(220), IDH2(12), IDH3B(1), OGDHL(1), PC(1), PCK1(1), SDHA(3), SDHC(1)	12856133	243	233	15	1	212	12	1	16	2	0	<1.00e-15	<1.00e-15	<5.13e-14
3	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(1), IDH1(220), IDH2(12), IDH3B(1), PC(1), PCK1(1), SDHA(3)	8868606	239	232	11	0	210	12	1	15	1	0	<1.00e-15	<1.00e-15	<5.13e-14
4	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	CDKN2A(1), MDM2(2), PIK3CA(28), PIK3R1(14), POLR1A(1), RB1(3), TBX2(1), TP53(185)	8752049	235	178	126	5	65	65	4	46	50	5	<1.00e-15	<1.00e-15	<5.13e-14
5	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	109	ANAPC2(1), ANAPC7(1), ATR(1), BUB1(1), BUB3(1), CCNA1(2), CCNB1(1), CCNB2(1), CCNB3(1), CCNE2(1), CDC14B(2), CDC16(1), CDC25B(1), CDKN1B(1), CDKN2A(1), CDKN2C(1), CHEK2(1), CREBBP(4), CUL1(1), FZR1(1), HDAC2(3), MCM6(1), MCM7(1), MDM2(2), PLK1(1), PRKDC(3), RB1(3), SKP2(1), SMAD2(1), SMAD3(1), SMC1B(1), TP53(185), WEE1(1), YWHAE(1), YWHAH(1)	58395004	231	167	136	17	69	59	3	51	44	5	3.99e-13	<1.00e-15	<5.13e-14
6	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	EGFR(21), IGF1R(2), POLR2A(1), PRKCA(1), RB1(3), TEP1(2), TERT(1), TP53(185)	12161005	216	167	115	6	71	53	2	49	36	5	<1.00e-15	<1.00e-15	<5.13e-14
7	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	64	ATR(1), BAI1(1), BAX(1), CCNB1(1), CCNB2(1), CCNB3(1), CCNE2(1), CCNG2(1), CDKN2A(1), CHEK2(1), CYCS(1), DDB2(1), GTSE1(1), MDM2(2), MDM4(1), PTEN(13), RFWD2(2), SESN3(1), SIAH1(1), THBS1(1), TP53(185), TSC2(2), ZMAT3(1)	28129770	222	166	127	9	69	56	2	51	39	5	<1.00e-15	<1.00e-15	<5.13e-14
8	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(4), PML(1), RB1(3), SP100(2), TNF(1), TP53(185)	8197018	196	156	101	6	67	47	2	41	34	5	<1.00e-15	<1.00e-15	<5.13e-14
9	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	BAX(1), CYCS(1), PRKCA(1), TLN1(3), TP53(185)	11792561	191	149	96	4	66	45	2	42	31	5	<1.00e-15	<1.00e-15	<5.13e-14
10	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	EIF2S2(1), NFKBIA(1), TP53(185)	4219956	187	147	92	3	64	45	2	40	31	5	<1.00e-15	<1.00e-15	<5.13e-14
11	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	CDKN1B(1), CDKN2A(1), CFL1(1), MDM2(2), PRB1(2), TP53(185)	3634115	192	147	97	2	64	48	2	41	32	5	<1.00e-15	<1.00e-15	<5.13e-14
12	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	DOCK1(1), FOS(1), HGF(2), MAPK1(1), MAPK8(1), MET(4), PAK1(1), PIK3CA(28), PIK3R1(14), PTEN(13), PTK2B(1), PTPN11(5), RAF1(1), RASA1(2), STAT3(1)	19010561	76	64	61	4	4	29	2	16	25	0	1.08e-05	<1.00e-15	<5.13e-14
13	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(1), IDH1(220), IDH2(12)	3829902	233	232	6	0	209	8	1	15	0	0	2.00e-15	1.11e-15	5.26e-14
14	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(3), BAX(1), MAPK8(1), MDM2(2), TP53(185)	8955790	192	149	97	4	65	47	3	40	32	5	<1.00e-15	1.33e-15	5.63e-14
15	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	CCNA1(2), CCNB1(1), CCNE2(1), CCNG2(1), CDKN1B(1), CDKN2A(1), CDKN2C(1), CREB3(3), MCM6(1), MCM7(1), MDM2(2), MYT1(2), POLE(1), PRIM1(1), RB1(3), RPA1(1), TNXB(4), TP53(185), WEE1(1)	33251409	213	157	118	9	68	51	2	43	44	5	<1.00e-15	1.44e-15	5.63e-14
16	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	MAX(3), SP3(2), TP53(185)	3042518	190	151	94	2	66	46	2	40	31	5	<1.00e-15	1.55e-15	5.63e-14
17	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	CHEK2(1), MAPK8(1), MDM2(2), NFKBIA(1), RAD50(1), RBBP8(1), TP53(185)	12826627	192	148	97	4	64	50	2	40	31	5	<1.00e-15	1.55e-15	5.63e-14
18	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(1), CHD8(2), CREBBP(4), CSNK1A1L(1), CSNK2A1(1), CTNNB1(1), CUL1(1), CXXC4(1), DKK2(2), DVL2(1), FZD10(1), FZD5(1), FZD6(1), FZD7(1), FZD9(1), LRP6(2), MAPK8(1), MAPK9(1), NFAT5(2), NFATC1(1), NFATC2(2), NFATC4(1), NKD2(1), PLCB1(2), PLCB2(3), PLCB4(1), PPP2R2C(1), PPP3R2(1), PRKACG(1), PRKCA(1), PRKCG(1), RAC2(1), ROCK2(1), SENP2(1), SFRP2(1), SIAH1(1), SMAD2(1), SMAD3(1), SOX17(3), TBL1XR1(1), TBL1Y(1), TCF7L2(2), TP53(185), VANGL2(1), WIF1(2), WNT11(2), WNT16(1), WNT2(1), WNT7A(1), WNT8A(1), WNT9B(1)	69826611	251	178	156	20	86	61	2	53	44	5	<1.00e-15	1.89e-15	5.70e-14
19	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATR(1), CCNB1(1), CDC25B(1), CDC34(1), CHEK2(1), MDM2(2), MYT1(2), PRKDC(3), RPS6KA1(1), TP53(185), WEE1(1), YWHAH(1)	17921597	200	149	105	3	66	48	3	43	35	5	<1.00e-15	1.89e-15	5.70e-14
20	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATR(1), CHEK2(1), TP53(185), YWHAH(1)	6876326	188	146	93	2	65	46	2	39	31	5	<1.00e-15	1.89e-15	5.70e-14
21	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	IFNGR2(1), JAK2(1), NFKBIA(1), RB1(3), TNF(1), TP53(185)	7830332	192	152	97	4	64	46	2	39	36	5	<1.00e-15	2.00e-15	5.70e-14
22	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	BAX(1), CYCS(1), FASLG(1), MAP3K1(2), MDM2(2), NFKBIA(1), PARP1(2), PRF1(1), RIPK1(1), TNF(1), TP53(185), TRADD(1)	16136741	199	152	104	8	67	49	2	43	33	5	<1.00e-15	2.11e-15	5.70e-14
23	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	G6PD(2), GGT1(2), GPX2(1), GSS(1), IDH1(220), IDH2(12)	7788577	238	233	11	3	212	9	1	16	0	0	<1.00e-15	2.22e-15	5.70e-14
24	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(1), CTLA4(1), HLA-DRA(1), PIK3CA(28), PIK3R1(14), PTPN11(5)	5513904	50	42	35	2	3	19	2	10	16	0	0.000243	2.22e-15	5.70e-14
25	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATR(1), BRCA2(2), CHEK2(1), FANCC(1), FANCD2(2), FANCE(2), RAD17(1), RAD50(1), RAD9A(1), TP53(185), TREX1(1)	18972653	198	153	103	4	66	50	2	42	33	5	<1.00e-15	2.33e-15	5.74e-14
26	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	BAX(1), MDM2(2), RB1(3), TP53(185)	7794672	191	150	96	2	64	46	2	40	34	5	<1.00e-15	2.55e-15	6.05e-14
27	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	G6PD(2), GGT1(2), GPX2(1), GSS(1), IDH1(220), IDH2(12)	9502584	238	233	11	4	212	9	1	16	0	0	<1.00e-15	2.78e-15	6.33e-14
28	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ATR(1), CCNA1(2), CDKN1B(1), CDKN2A(1), RB1(3), SKP2(1), TP53(185)	12995477	194	150	99	3	65	46	2	41	35	5	<1.00e-15	3.00e-15	6.59e-14
29	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), EGF(3), EGFR(21), FOS(1), MAP3K1(2), MAPK8(1), PIK3CA(28), PIK3R1(14), PLCG1(4), PRKCA(1), RAF1(1), RASA1(2), SHC1(1), SRF(1), STAT3(1)	16164259	82	65	61	5	7	33	2	18	22	0	6.52e-06	3.11e-15	6.60e-14
30	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	EIF4A1(2), EIF4A2(1), EIF4B(1), EIF4G1(3), EIF4G3(3), MKNK1(1), PIK3CA(28), PIK3R1(14), PTEN(13), TSC1(1), TSC2(2)	11906558	69	59	55	2	5	28	2	13	21	0	2.18e-06	3.22e-15	6.61e-14
31	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	CDC25B(1), MYT1(2), RB1(3), TP53(185), WEE1(1), YWHAH(1)	7565506	193	150	98	2	65	45	2	39	37	5	<1.00e-15	3.66e-15	7.25e-14
32	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	GH1(1), GHR(1), IGF1R(2), PIK3CA(28), PIK3R1(14), SHC1(1)	5747747	47	41	33	1	1	20	2	7	17	0	4.55e-05	3.77e-15	7.25e-14
33	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ARPC1B(1), PAK1(1), PDGFRA(7), PIK3CA(28), PIK3R1(14)	5770746	51	41	37	3	1	22	2	6	20	0	0.00116	3.89e-15	7.25e-14
34	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	BAX(1), CASP1(1), CYCS(1), FASLG(1), MAP3K1(2), MDM2(2), NFKBIA(1), PLEKHG5(1), PRF1(1), RIPK1(1), TNF(1), TP53(185), TRADD(1)	24731875	199	150	104	11	68	48	2	43	33	5	1.89e-15	4.44e-15	7.54e-14
35	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	ATF2(1), IL1R1(1), MAP2K5(1), MAP3K1(2), MAP3K10(1), MAP3K12(2), MAP3K13(1), MAP3K4(2), MAP3K5(2), MAPK7(3), MAPK8(1), MAPK9(1), PAPPA(2), SHC1(1), TP53(185)	21715364	206	149	111	7	66	53	2	45	35	5	<1.00e-15	4.44e-15	7.54e-14
36	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	EIF4A1(2), EIF4A2(1), EIF4G1(3), EIF4G3(3), GHR(1), IRS1(2), MAPK1(1), MKNK1(1), PABPC1(2), PIK3CA(28), PIK3R1(14), PRKCA(1), PTEN(13)	12122047	72	62	58	6	7	28	2	12	23	0	0.000462	4.66e-15	7.54e-14
37	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(1), FOS(1), IRS1(2), MAPK8(1), PIK3CA(28), PIK3R1(14), PTPN11(5), RAF1(1), RASA1(2), SHC1(1), SRF(1)	11010504	57	50	42	4	2	23	2	11	19	0	0.000507	4.77e-15	7.54e-14
38	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(1), ANXA1(2), GNAS(3), NOS3(3), NR3C1(1), PIK3CA(28), PIK3R1(14)	7756817	52	43	38	3	6	20	2	6	18	0	0.000476	4.77e-15	7.54e-14
39	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	PIK3CA(28), PIK3R1(14), PLCG1(4), PRKCA(1), SHC1(1)	6705887	48	42	33	3	2	21	2	6	17	0	0.000928	4.77e-15	7.54e-14
40	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	80	BAX(1), CSF2RB(1), CYCS(1), FASLG(1), IL1R1(1), IRAK3(1), IRAK4(1), NFKBIA(1), PIK3CA(28), PIK3CG(2), PIK3R1(14), PIK3R5(1), PPP3R2(1), PRKACG(1), PRKAR1A(2), RIPK1(1), TNF(1), TNFRSF10C(1), TP53(185), TRADD(1)	36058709	246	180	137	16	68	68	5	49	51	5	<1.00e-15	5.33e-15	7.82e-14
41	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	MAPK1(1), MAPK7(3), PIK3CA(28), PIK3R1(14), PLCG1(4), RPS6KA1(1), SHC1(1)	8174470	52	45	37	3	1	23	2	8	18	0	0.000357	5.44e-15	7.82e-14
42	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	BUB1(1), BUB3(1), CCNA1(2), CCNB1(1), CCNB2(1), CCNB3(1), CCNE2(1), CDC14B(2), CDC25B(1), CDH1(1), CDKN2A(1), CHEK2(1), HDAC2(3), HDAC4(2), HDAC5(1), HDAC6(2), MCM6(1), MCM7(1), MDM2(2), MPEG1(1), PLK1(1), PRKDC(3), RB1(3), SKP2(1), TP53(185), WEE1(1)	47247509	221	160	126	14	70	55	3	48	40	5	1.99e-14	5.66e-15	7.82e-14
43	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	PIK3CA(28), PIK3R1(14), PLCB1(2), PLCG1(4), PRKCA(1), VAV1(3)	5530117	52	45	37	3	4	21	2	8	17	0	0.000474	5.66e-15	7.82e-14
44	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	CDKN1B(1), MAPK1(1), PIK3CA(28), PIK3R1(14), PTEN(13), SHC1(1)	8325110	58	52	44	3	2	23	2	11	20	0	0.000184	6.00e-15	7.82e-14
45	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(1), FOS(1), MAPK8(1), PIK3CA(28), PIK3R1(14), PLCG1(4), RAF1(1), SHC1(1)	8240797	51	44	36	2	1	24	2	6	18	0	7.35e-05	6.00e-15	7.82e-14
46	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	BAX(1), CAD(2), CASP8AP2(1), DEDD2(1), EGFR(21), FAF1(1), MAP3K1(2), MAP3K5(2), MAPK1(1), MAPK8(1), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1), MET(4), NFAT5(2), NFKBIA(1), RIPK1(1), TNFRSF6B(1), TP53(185), TPX2(1)	31319339	231	166	130	7	68	61	2	51	44	5	<1.00e-15	6.11e-15	7.82e-14
47	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(1), FOS(1), IGF1R(2), IRS1(2), MAPK8(1), PIK3CA(28), PIK3R1(14), PTPN11(5), RAF1(1), RASA1(2), SHC1(1), SRF(1)	10702541	59	52	44	4	2	24	2	11	20	0	0.000302	6.11e-15	7.82e-14
48	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	MAP2K3(1), MAP2K6(1), MAP3K1(2), MAPK1(1), PIK3CA(28), PIK3R1(14), RB1(3)	8379845	50	44	36	3	3	20	2	5	20	0	0.000803	6.22e-15	7.82e-14
49	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	CDKN1B(1), MAPK1(1), NFKBIA(1), PAK1(1), PIK3CA(28), PIK3R1(14), RAF1(1), RB1(3)	8720946	50	43	36	3	1	19	2	5	23	0	0.000831	6.22e-15	7.82e-14
50	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	APC(1), AR(1), BRAF(3), DAG1(1), EGFR(21), GNAI1(3), ITPR1(2), ITPR2(4), ITPR3(4), MAPK1(1), PHKA2(2), PIK3CA(28), PIK3R1(14), PITX2(1), PTX3(1), RAF1(1)	23066937	88	73	68	4	7	33	3	23	22	0	4.43e-07	6.55e-15	8.07e-14
51	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	EIF2S2(1), IGF1R(2), INPPL1(1), PIK3CA(28), PIK3R1(14), PTEN(13)	8469014	59	53	45	2	2	24	2	11	20	0	2.08e-05	7.44e-15	8.81e-14
52	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	IL18(2), KLRC2(1), LAT(1), PAK1(1), PIK3CA(28), PIK3R1(14), PTK2B(1), VAV1(3)	8026572	51	44	37	4	4	21	2	7	17	0	0.00144	7.44e-15	8.81e-14
53	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	CFL1(1), LIMK1(3), MAP3K1(2), MYLK(1), NCF2(1), PAK1(1), PDGFRA(7), PIK3CA(28), PIK3R1(14), PLD1(3), TRIO(2), VAV1(3)	15056606	66	54	52	3	8	24	3	9	22	0	1.21e-05	7.88e-15	9.08e-14
54	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(1), BAX(1), CSF2RB(1), IGF1R(2), KIT(2), PIK3CA(28), PIK3R1(14), PRKACG(1), PRKAR1A(2), YWHAH(1)	9466371	53	45	39	3	3	19	2	8	21	0	0.000466	7.99e-15	9.08e-14
55	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	GH1(1), GHR(1), NFKBIA(1), PIK3CA(28), PIK3R1(14), YWHAH(1)	6072506	46	40	32	2	1	19	2	6	18	0	0.000424	8.10e-15	9.08e-14
56	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	MAPK1(1), PDK1(2), PIK3CA(28), PTEN(13), PTK2B(1), SHC1(1)	8790153	46	42	34	3	1	19	2	13	11	0	0.000732	1.07e-13	1.17e-12
57	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	NOTCH1(33)	4064585	33	29	27	2	1	6	0	8	16	2	0.0719	1.99e-13	2.15e-12
58	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	IGF1R(2), IRS1(2), MAPK1(1), PIK3CA(28), PIK3R1(14), RAF1(1), SHC1(1), YWHAH(1)	8175396	50	43	36	4	2	21	2	6	19	0	0.00149	2.23e-13	2.37e-12
59	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	H2AFX(1), PIK3CA(28), PIK3R1(14), RAF1(1), RALA(1), RALGDS(2)	8237438	47	39	33	3	2	19	2	5	19	0	0.00111	3.21e-13	3.35e-12
60	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(1), FOS(1), JAK2(1), PIK3CA(28), PIK3R1(14), PLCG1(4), PRKCA(1), RAF1(1), RASA1(2), SHC1(1), STAT3(1), STAT5B(1)	12904232	56	47	41	3	3	23	2	8	20	0	0.000178	7.02e-13	7.21e-12
61	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(3), EGFR(21), ERBB2(1), ERBB4(1), ETS1(1), ETV6(2), FMN2(2), KRAS(1), MAPK1(1), NOTCH1(33), NOTCH2(5), NOTCH3(4), NOTCH4(5), PIWIL2(2), PIWIL3(1), RAF1(1), SOS2(1), SPIRE1(1)	22668639	86	73	74	6	13	20	1	25	24	3	5.59e-05	7.42e-13	7.49e-12
62	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	MUSK(3), PIK3CA(28), PIK3R1(14), PTK2B(1), TERT(1), YWHAH(1)	7068622	48	41	34	5	2	20	2	6	18	0	0.00729	1.02e-11	1.01e-10
63	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	BCR(1), FOS(1), JAK2(1), MAP3K1(2), MAPK8(1), PIK3CA(28), PIK3R1(14), RAF1(1), STAT5B(1)	12110220	50	42	36	3	2	22	2	6	18	0	0.000360	7.08e-11	6.92e-10
64	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	CABIN1(2), HDAC5(1), IGF1R(2), MAP2K6(1), MAPK7(3), NFATC1(1), NFATC2(2), PIK3CA(28), PIK3R1(14), YWHAH(1)	15025293	55	47	41	3	3	21	3	7	21	0	0.000128	5.79e-10	5.57e-09
65	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), FOS(1), MAP3K1(2), MAPK8(1), PDGFA(1), PDGFRA(7), PIK3CA(28), PIK3R1(14), PLCG1(4), PRKCA(1), RAF1(1), RASA1(2), SHC1(1), SRF(1), STAT3(1)	15059600	66	53	51	6	5	28	2	8	23	0	0.000780	1.00e-09	9.48e-09
66	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(3), EGFR(21), ERBB3(1), NRG1(1)	4441966	26	22	20	0	4	8	0	11	3	0	0.000929	6.12e-09	5.71e-08
67	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(1), EGF(3), EGFR(21), HGS(2), TFRC(2)	5518510	29	24	23	1	5	9	0	12	3	0	0.00221	6.44e-09	5.92e-08
68	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	EGF(3), EGFR(21), MET(4), PDGFRA(7), PRKCA(1), SH3KBP1(1)	8370159	37	30	31	2	4	12	0	14	7	0	0.00193	1.19e-08	1.07e-07
69	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	MAPK1(1), MAPK12(1), MAPK8(1), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1), MAPKAPK5(2), NFKBIA(1), PIK3CA(28), PIK3R1(14)	14546889	51	44	37	3	2	21	2	8	18	0	0.000312	1.43e-08	1.27e-07
70	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	PIK3CA(28), SHC1(1)	6986876	29	26	17	1	0	13	2	6	8	0	0.00118	1.77e-08	1.56e-07
71	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	CALR(1), CREBBP(4), F2(3), GATA4(1), MAPK1(1), MAPK8(1), MYH2(9), NFATC1(1), NFATC2(2), NFATC4(1), PIK3CA(28), PIK3R1(14), PRKACG(1), PRKAR1A(2), RAF1(1)	21898046	70	58	56	5	11	24	2	12	21	0	3.78e-05	2.05e-08	1.77e-07
72	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	CDKN2A(1), PDK1(2), PIK3CA(28), PTEN(13), RPS6KA1(1), RPS6KA3(1), SHC1(1), SOS2(1), TEC(1), YWHAE(1), YWHAH(1)	15499559	51	47	39	4	1	17	2	19	12	0	0.00219	3.75e-08	3.21e-07
73	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(1), GHR(1), IRS1(2), JAK2(1), MAPK1(1), PIK3CA(28), PIK3R1(14), PLCG1(4), PRKCA(1), RAF1(1), RPS6KA1(1), SHC1(1), SRF(1), STAT5B(1)	14257511	58	50	43	6	3	24	2	9	20	0	0.00253	4.93e-08	4.16e-07
74	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(1), GNAI1(3), MAPK1(1), PDGFA(1), PDGFRA(7), PIK3CA(28), PIK3R1(14), PLCB1(2), PRKCA(1), SMPD2(1)	11827152	59	46	45	7	5	23	2	9	20	0	0.00685	5.05e-08	4.20e-07
75	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	BRAF(3), CREB3(3), CREBBP(4), DAG1(1), MAP1B(2), MAPK1(1), MAPK8(1), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1), PIK3CA(28), PIK3R1(14), PTPN11(5), RPS6KA3(1), SHC1(1), TH(1)	22225947	68	58	53	5	3	26	2	16	21	0	0.000270	1.25e-07	1.02e-06
76	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(1), F2(3), GNAI1(3), PIK3CA(28), PIK3R1(14), PLCB1(2), PRKCA(1), PTK2B(1)	11151433	53	43	39	6	3	21	2	9	18	0	0.00693	1.83e-07	1.49e-06
77	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(4), IL7R(1), JAK3(1), PIK3CA(28), PIK3R1(14), PTK2B(1), STAT5B(1)	12081469	50	42	36	5	2	20	2	9	17	0	0.00615	1.86e-07	1.49e-06
78	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	CXCR4(1), GNAI1(3), MAPK1(1), PIK3CA(28), PIK3R1(14), PLCG1(4), PRKCA(1), PTK2B(1), RAF1(1)	11926081	54	46	39	6	2	24	3	6	19	0	0.00400	1.89e-07	1.49e-06
79	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	BRD4(1), CDKN2A(1), FLOT1(1), FLOT2(2), INPPL1(1), IRS1(2), IRS4(2), MAPK1(1), PDK1(2), PIK3CA(28), PIK3R1(14), PPYR1(1), PTEN(13), RAF1(1), RPS6KA1(1), RPS6KA3(1), SHC1(1), SOS2(1), YWHAE(1), YWHAH(1)	25706020	76	65	62	6	5	27	2	20	22	0	0.000155	2.40e-07	1.87e-06
80	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(1), GNAS(3), MAPK1(1), PIK3CA(28), PIK3R1(14), PRKACG(1), PRKAR1A(2), PRKCA(1), RPS6KA1(1)	12570769	52	44	38	6	5	19	2	8	18	0	0.0161	3.90e-07	3.00e-06
81	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	DIAPH1(2), MAPK1(1), MYLK(1), PIK3CA(28), PIK3R1(14), RAF1(1), SHC1(1), TLN1(3)	16070441	51	44	37	4	4	19	2	9	17	0	0.00161	6.94e-07	5.28e-06
82	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	FOS(1), LAT(1), MAP3K1(2), MAPK8(1), NFATC1(1), NFATC2(2), NFATC4(1), NFKBIA(1), PIK3CA(28), PIK3R1(14), PLCG1(4), PRKCA(1), RAF1(1), RASA1(2), SHC1(1), VAV1(3), ZAP70(2)	20628598	66	56	51	6	8	26	2	9	21	0	0.000277	9.17e-07	6.89e-06
83	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	FOS(1), MAP3K1(2), MAPK1(1), MAPK8(1), NFATC1(1), NFATC2(2), NFATC4(1), PIK3CA(28), PIK3R1(14), PLA2G4A(4), PLCG1(4), RAF1(1), SHC1(1), VAV1(3)	18566232	64	53	49	6	6	27	2	10	19	0	0.000493	1.02e-06	7.57e-06
84	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	APC(1), CTNNB1(1), GJA1(1), GNAI1(3), LBP(1), PIK3CA(28), PIK3R1(14), TOLLIP(1)	13275021	50	43	36	5	2	19	2	8	19	0	0.00808	1.17e-06	8.57e-06
85	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	EIF2B4(1), EIF2S2(1), FLT4(1), KDR(4), NOS3(3), PIK3CA(28), PIK3R1(14), PLCG1(4), PRKCA(1), SHC1(1)	14673083	58	49	43	8	7	23	2	8	18	0	0.00885	3.56e-06	2.58e-05
86	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(3), EGFR(21), MAP3K1(2), NCOR2(3), RXRA(1), THRA(1)	7476117	31	27	25	3	6	10	0	11	4	0	0.0141	4.75e-06	3.40e-05
87	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	IDH2(12), SDHA(3)	4047423	15	15	5	0	1	9	1	4	0	0	0.00567	5.47e-06	3.87e-05
88	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(1), CTNNB1(1), NOTCH1(33)	9301935	35	31	29	4	1	6	0	9	17	2	0.256	6.69e-06	4.68e-05
89	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	BCR(1), CDKN2A(1), FLOT1(1), FLOT2(2), ITPR1(2), ITPR2(4), ITPR3(4), PDK1(2), PIK3CA(28), PITX2(1), PLCG2(4), PREX1(2), PTEN(13), PTPRC(3), RPS6KA1(1), RPS6KA3(1), SAG(1), TEC(1), VAV1(3)	23813931	75	64	63	9	13	24	3	24	11	0	0.000811	1.01e-05	7.02e-05
90	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ANGPTL2(1), DAG1(1), DGKA(1), ITPR1(2), ITPR2(4), ITPR3(4), MAPK1(1), PAK1(1), PDE3A(1), PI3(1), PIK3CA(28), PIK3R1(14), RPS4X(1)	20992975	60	52	46	6	3	26	3	11	17	0	0.00158	1.28e-05	8.79e-05
91	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	CISH(1), IL13RA1(1), IL4R(1), JAK2(1), JAK3(1), PI3(1), PIK3CA(28), SHC1(1), SOS2(1), STAT6(2), TYK2(2)	15931726	40	35	28	2	3	13	3	10	11	0	0.000489	3.99e-05	0.000270
92	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	AGTR2(1), EGF(3), EGFR(21), FOS(1), PLCG1(4), PRKCA(1)	8845531	31	25	24	3	5	12	0	11	3	0	0.0112	4.39e-05	0.000294
93	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	INPP4B(1), INPPL1(1), OCRL(2), PIK3C2B(1), PIK3CA(28), PIK3CG(2), PLCB1(2), PLCB2(3), PLCB4(1), PLCG1(4), PLCG2(4)	19290465	49	43	36	4	7	20	3	10	9	0	0.000502	6.30e-05	0.000417
94	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	EGF(3), EGFR(21), MAPK1(1), PTPRB(2), RAF1(1), RASA1(2), SHC1(1), SPRY2(1), SPRY4(1)	10745329	33	26	27	3	3	10	0	13	7	0	0.0111	0.000217	0.00142
95	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	FN3K(1), INPP4B(1), INPPL1(1), ISYNA1(1), OCRL(2), PI4KA(2), PI4KB(2), PIK3CA(28), PIK3CG(2), PIP4K2B(1), PIP4K2C(2), PLCB1(2), PLCB2(3), PLCB4(1), PLCD3(2), PLCE1(3), PLCG1(4), PLCG2(4), PLCZ1(1), PTEN(13), PTPMT1(1), SYNJ1(1), SYNJ2(3)	32059650	81	67	68	8	11	29	3	18	20	0	0.000173	0.000239	0.00155
96	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	BRAF(3), EIF4B(1), MAPK1(1), PGF(1), PIK3CA(28), PIK3CG(2), PIK3R1(14), PIK3R5(1), PRKAA1(1), RPS6KA1(1), RPS6KA3(1), RPS6KA6(1), TSC1(1), TSC2(2), ULK2(1), VEGFB(2), VEGFC(2)	22963416	63	51	48	6	4	23	5	14	17	0	0.000966	0.000266	0.00171
97	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	IL4R(1), IRS1(2), JAK3(1), MAPK1(1), PDK1(2), PIK3CA(28), PIK3R1(14), RAF1(1), SHC1(1), SOS2(1), STAT6(2)	15780463	54	45	40	8	3	20	2	11	18	0	0.0231	0.000306	0.00194
98	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	GAB2(1), KRAS(1), LAT(1), MAP2K3(1), MAP2K6(1), MAPK1(1), MAPK12(1), MAPK8(1), MAPK9(1), NRAS(1), PDK1(2), PIK3CA(28), PIK3CG(2), PIK3R1(14), PIK3R5(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PLCG1(4), PLCG2(4), PRKCA(1), RAC2(1), RAF1(1), SOS2(1), TNF(1), VAV1(3), VAV3(8)	31114900	88	75	66	10	12	31	3	14	28	0	0.000660	0.000345	0.00217
99	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	BCR(1), DAG1(1), MAPK1(1), NFAT5(2), NFKBIA(1), PI3(1), PIK3CA(28), PIK3R1(14), PLCG2(4), RAF1(1), SHC1(1), SOS2(1), VAV1(3)	22738490	59	51	45	6	6	22	2	10	19	0	0.00135	0.000609	0.00379
100	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	CDKN1B(1), CDKN2A(1), CREB3(3), ERBB4(1), INPPL1(1), IRS1(2), IRS4(2), MET(4), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PDK1(2), PIK3CA(28), PREX1(2), PTEN(13), RPS6KA1(1), RPS6KA3(1), SHC1(1), SOS2(1), TSC1(1), TSC2(2), YWHAE(1), YWHAH(1)	33331941	73	66	61	7	4	23	2	26	18	0	0.000512	0.000617	0.00380
101	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(3), GABRA3(2), GABRA4(3), GABRA5(1), GABRA6(3)	3395416	12	12	12	2	5	3	0	4	0	0	0.209	0.000717	0.00437
102	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(5)	870909	5	5	5	0	3	1	0	0	1	0	0.266	0.00151	0.00911
103	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ANGPTL2(1), CFL1(1), GDI1(2), INPPL1(1), ITPR1(2), ITPR2(4), ITPR3(4), LIMK1(3), MYLK(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PDK1(2), PIK3CA(28), PIK3CG(2), PIK3R1(14), PITX2(1), PTEN(13), ROCK2(1), RPS4X(1), SAG(1)	30207956	86	72	72	12	8	32	4	21	21	0	0.00271	0.00265	0.0159
104	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	BRAF(3), DAG1(1), EGFR(21), ITPR1(2), ITPR2(4), ITPR3(4), MAPK1(1), PI3(1), PITX2(1), PLCB1(2), PLCB2(3), PLCB4(1), RAF1(1), SHC1(1), SOS2(1), STAT3(1)	25233789	48	43	42	3	8	15	1	20	4	0	0.000365	0.00481	0.0284
105	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	FOS(1), IL2RB(2), IRS1(2), JAK3(1), MAPK1(1), PIK3CA(28), PIK3R1(14), RAF1(1), SHC1(1), STAT5B(1)	15614863	52	43	38	9	2	22	2	9	17	0	0.0467	0.00483	0.0284
106	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1C(1), ARRB2(1), ATF2(1), BRAF(3), CACNA1A(2), CACNA1B(4), CACNA1D(1), CACNA1E(6), CACNA1F(3), CACNA1G(1), CACNA1H(2), CACNA1I(1), CACNA1S(5), CACNA2D3(1), CACNA2D4(1), CACNB2(1), CACNB3(1), CACNG3(3), CACNG7(1), CACNG8(1), CDC25B(1), DDIT3(1), DUSP16(1), DUSP5(2), EGF(3), EGFR(21), FASLG(1), FGF4(1), FGF5(2), FGF6(1), FGF7(1), FGFR2(1), FGFR4(1), FLNA(3), FLNB(4), FLNC(4), FOS(1), GNG12(1), IL1R1(1), IL1R2(1), KRAS(1), MAP2K3(1), MAP2K5(1), MAP2K6(1), MAP3K1(2), MAP3K10(1), MAP3K12(2), MAP3K13(1), MAP3K4(2), MAP3K5(2), MAP4K4(1), MAPK1(1), MAPK12(1), MAPK7(3), MAPK8(1), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1), MAPKAPK5(2), MAX(3), MKNK1(1), NF1(20), NFATC2(2), NFATC4(1), NR4A1(1), NRAS(1), PAK1(1), PDGFA(1), PDGFRA(7), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PPM1B(1), PPP3R2(1), PRKACG(1), PRKCA(1), PRKCG(1), PTPN5(1), PTPRR(2), RAC2(1), RAF1(1), RASA1(2), RASGRF2(2), RASGRP2(1), RASGRP4(1), RPS6KA1(1), RPS6KA3(1), RPS6KA6(1), RRAS(1), SOS2(1), SRF(1), STK3(1), TAOK1(2), TGFBR1(1), TGFBR2(1), TNF(1), TP53(185)	123530337	376	208	273	59	101	101	5	83	74	12	1.52e-10	0.00623	0.0362
107	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL2(1), BRAF(3), BTC(1), CBLB(1), CBLC(1), CDKN1B(1), EGF(3), EGFR(21), ERBB2(1), ERBB3(1), ERBB4(1), HBEGF(1), KRAS(1), MAPK1(1), MAPK8(1), MAPK9(1), NCK1(1), NRAS(1), NRG1(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PIK3CA(28), PIK3CG(2), PIK3R1(14), PIK3R5(1), PLCG1(4), PLCG2(4), PRKCA(1), PRKCG(1), RAF1(1), SHC1(1), SOS2(1), STAT5B(1)	44459158	106	85	85	11	14	35	3	28	26	0	3.21e-05	0.00792	0.0456
108	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	IDH2(12), IDH3B(1), PC(1), PDHA1(3), PDHA2(2), PDHB(1), PDK1(2), PDK3(1), SDHA(3), SDHC(1)	12217520	27	24	17	3	2	13	1	8	3	0	0.0150	0.00933	0.0532
109	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(1), IL12B(1), IL18(2)	1280747	4	4	4	1	1	0	1	2	0	0	0.619	0.0113	0.0639
110	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT2(1), AGPAT3(1), AGPS(1), ENPP2(2), PAFAH1B1(2), PAFAH1B3(1), PAFAH2(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PLD1(3)	9987119	19	18	19	1	3	5	2	7	2	0	0.0323	0.0115	0.0643
111	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACPP(3), ENPP1(1), ENPP3(2), FLAD1(1), TYR(2)	4172365	9	9	9	1	3	3	0	1	2	0	0.206	0.0167	0.0927
112	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPP(4), ALPPL2(2), FPGS(2), SPR(1)	2821312	9	8	9	2	3	2	1	1	2	0	0.429	0.0192	0.105
113	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX3(1), FADS2(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4)	4369144	9	9	9	0	1	3	0	3	2	0	0.0742	0.0193	0.105
114	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(21), GNAS(3), IGF1R(2), MAPK1(1), MKNK1(1), PDGFRA(7), PTPRR(2), RAF1(1), RPS6KA1(1), SHC1(1), STAT3(1)	14280875	41	35	35	6	4	14	0	14	9	0	0.0446	0.0298	0.161
115	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(2), CDC34(1), CUL1(1), RB1(3), SKP2(1)	3677825	8	8	8	0	0	2	0	1	5	0	0.252	0.0318	0.170
116	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	ATF2(1), EGFR(21), MAP3K1(2), MAPK1(1), MAPK8(1), PAK1(1), PRKCA(1), PTK2B(1), RAF1(1), SHC1(1)	14459446	31	27	25	4	4	11	0	11	5	0	0.0375	0.0382	0.203
117	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(1), ANKRD1(1), HBEGF(1), IFRD1(2), IL18(2), IL1R1(1), NR4A3(1)	4628694	9	9	9	1	2	3	0	1	3	0	0.302	0.0449	0.237
118	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F2(3), F5(4), F7(1), FGA(1), FGB(1), FGG(1), PROS1(1)	7048274	12	12	12	1	4	4	0	2	2	0	0.0625	0.0657	0.343
119	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	APOA1(1), CD36(1), CREBBP(4), HSD17B4(2), LPL(1), MAPK1(1), NCOA1(1), NCOR1(3), NCOR2(3), NFKBIA(1), NR1H3(1), PDGFA(1), PIK3CA(28), PIK3R1(14), PRKACG(1), PRKAR1A(2), PRKCA(1), PTGS2(1), RB1(3), RXRA(1), STAT5B(1), TNF(1)	27294864	73	63	59	13	7	27	3	11	25	0	0.0350	0.0697	0.360
120	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BRAF(3), CREB3(3), MAPK1(1), RAF1(1)	4799126	8	8	8	0	0	2	0	2	4	0	0.222	0.0701	0.360
121	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CDKN1B(1), CUL1(1), RB1(3), SKP2(1), UBE2M(1)	3686822	7	7	7	0	0	2	0	1	4	0	0.218	0.0736	0.375
122	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(1), TAT(1), TYR(2)	2028505	4	4	4	1	2	0	1	1	0	0	0.583	0.0786	0.397
123	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACPP(3), ENPP1(1), ENPP3(2), FLAD1(1), MTMR6(1), TYR(2)	6468112	10	10	10	1	3	4	0	1	2	0	0.147	0.0892	0.447
124	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	KDR(4), KRAS(1), MAPK1(1), MAPK12(1), NFAT5(2), NFATC1(1), NFATC2(2), NFATC4(1), NOS3(3), NRAS(1), PIK3CA(28), PIK3CG(2), PIK3R1(14), PIK3R5(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PLCG1(4), PLCG2(4), PPP3R2(1), PRKCA(1), PRKCG(1), PTGS2(1), RAC2(1), RAF1(1), SH2D2A(1)	31116714	84	68	69	13	14	31	3	14	22	0	0.00154	0.0952	0.473
125	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	LPO(3), MPO(2), TPO(3), TYR(2)	4164396	10	9	10	2	6	2	0	2	0	0	0.267	0.0968	0.477
126	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	CYP1A2(2), CYP2C19(5), CYP2C8(1), CYP3A4(2), CYP3A7(1), HSD3B7(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4)	10290036	19	18	19	2	7	4	0	5	3	0	0.0693	0.100	0.489
127	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(1), ATP6V0A2(1), ATP6V1C2(1), ATP6V1D(1), EGFR(21), HBEGF(1), JAM2(1), MAPK12(1), MAPK8(1), MAPK9(1), MET(4), NFKBIA(1), PAK1(1), PLCG1(4), PLCG2(4), PTPN11(5), PTPRZ1(4), TCIRG1(1), TJP1(3)	30307130	57	45	49	5	9	19	0	17	12	0	0.000612	0.102	0.493
128	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(1), FHL5(1), FSHR(1), GNAS(3), XPO1(1)	4125185	7	7	7	1	2	1	1	2	1	0	0.468	0.116	0.560
129	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	GABRA1(3), GABRA3(2), GABRA4(3), GABRA5(1), GABRA6(3)	5158397	12	12	12	3	5	3	0	4	0	0	0.384	0.119	0.567
130	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	CYCS(1), SDHA(3), SDHC(1), UQCRC1(1)	2845533	6	5	5	0	2	3	0	1	0	0	0.128	0.120	0.567
131	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(2), PC(1), PDHA1(3), SLC25A1(1)	3999603	7	7	7	1	0	2	0	3	2	0	0.306	0.121	0.569
132	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(2), NAT2(2), XDH(2)	3425900	6	6	6	0	4	0	0	1	1	0	0.134	0.123	0.573
133	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(1), CHRNA1(2)	1400897	3	3	3	0	1	1	0	0	1	0	0.300	0.125	0.573
134	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1)	3680157	7	7	7	1	5	0	0	0	2	0	0.240	0.126	0.573
135	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	RB1(3), SP3(2)	2857372	5	5	5	1	0	1	0	0	4	0	0.718	0.126	0.573
136	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	LARS(1), PDHA1(3), PDHA2(2), PDHB(1)	4316140	7	7	7	1	0	4	0	2	1	0	0.287	0.130	0.585
137	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	BCR(1), CD22(2), CR2(2), DAG1(1), FLOT1(1), FLOT2(2), ITPR1(2), ITPR2(4), ITPR3(4), MAPK1(1), NFATC1(1), NFATC2(2), PDK1(2), PIK3CA(28), PIK3R1(14), PLCG2(4), PTPRC(3), RAF1(1), SHC1(1), SOS2(1), VAV1(3)	31879911	80	69	66	13	14	27	3	18	18	0	0.00572	0.130	0.585
138	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CDC34(1), CUL1(1), FBXW7(1), RB1(3)	3551777	6	6	6	0	1	1	0	0	4	0	0.301	0.133	0.593
139	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IL12B(1), IL15(1), IL16(3), IL18(2), IL6(1), TNF(1)	4265951	9	9	9	2	2	2	1	3	1	0	0.413	0.134	0.593
140	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(1), GNAS(3), PRKAR1A(2)	2849516	6	6	6	1	3	0	0	2	1	0	0.562	0.144	0.634
141	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(2), ENPP1(1), ENPP3(2), NADSYN1(1), NNMT(1), NT5C(2), NT5E(1)	6271908	10	10	10	2	1	6	1	1	1	0	0.264	0.145	0.634
142	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	CHAT(1), PDHA1(3), PDHA2(2)	3014484	6	6	6	1	0	3	0	1	2	0	0.348	0.152	0.660
143	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(1), COQ5(2)	1732532	3	3	3	0	0	2	0	1	0	0	0.387	0.158	0.680
144	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1)	5706969	12	12	12	3	6	1	0	2	3	0	0.292	0.160	0.686
145	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACPP(3), ALPP(4), ALPPL2(2), CYP3A4(2), CYP3A7(1), DHRS2(1), DHRSX(1), PON1(2)	7756665	16	15	16	3	6	3	0	2	5	0	0.208	0.166	0.707
146	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1)	2424150	5	5	5	2	1	1	0	2	1	0	0.678	0.183	0.774
147	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(2), AGTR2(1), NOS3(3), REN(1)	4301265	7	7	7	1	4	1	0	0	2	0	0.334	0.192	0.803
148	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1)	709762	1	1	1	0	0	0	0	1	0	0	0.818	0.195	0.810
149	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3)	3450254	7	7	7	2	4	1	0	0	2	0	0.427	0.197	0.810
150	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3)	3450254	7	7	7	2	4	1	0	0	2	0	0.427	0.197	0.810
151	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(2), CCNE2(1), CDKN1B(1), CDKN2A(1), PRB1(2)	3867390	7	6	7	0	0	4	0	1	2	0	0.135	0.202	0.819
152	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(4), ACACB(5), ACAT2(1), ACSS1(2), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), LDHA(1), LDHAL6B(1), LDHB(1), PC(1), PCK1(1), PDHA1(3), PDHA2(2), PDHB(1), PKLR(1)	20185247	31	31	31	4	13	9	0	6	3	0	0.0129	0.202	0.819
153	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLUD1(2), GLUD2(1)	1963832	3	3	3	1	0	1	0	2	0	0	0.767	0.204	0.821
154	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	CARD11(3), CBLB(1), CBLC(1), CD28(1), CTLA4(1), FOS(1), KRAS(1), LAT(1), NCK1(1), NFAT5(2), NFATC1(1), NFATC2(2), NFATC4(1), NFKBIA(1), NRAS(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PDK1(2), PIK3CA(28), PIK3CG(2), PIK3R1(14), PIK3R5(1), PLCG1(4), PPP3R2(1), PRKCQ(1), PTPRC(3), SOS2(1), TEC(1), TNF(1), VAV1(3), VAV3(8), ZAP70(2)	43727805	95	77	73	12	15	31	3	16	30	0	0.000685	0.212	0.849
155	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(1), IDI1(1)	1355720	2	2	2	0	0	1	0	0	1	0	0.661	0.215	0.853
156	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(1), B3GNT5(2), ST3GAL3(1), ST3GAL4(1)	3100421	5	5	5	0	2	2	0	0	1	0	0.130	0.221	0.874
157	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	LPO(3), MPO(2), TPO(3)	3611032	8	7	8	2	5	2	0	1	0	0	0.376	0.223	0.874
158	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(2), ICAM1(1), ITGA4(1), ITGAL(2), ITGB2(1), SELE(3)	5209546	10	10	9	3	6	3	0	0	1	0	0.315	0.229	0.888
159	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(2)	790850	2	2	2	1	1	0	0	1	0	0	0.845	0.229	0.888
160	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(1), NR3C1(1), PPARG(1), RXRA(1), TNF(1)	2499615	5	5	5	2	0	3	0	2	0	0	0.658	0.243	0.936
161	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(2), PTGS1(1), PTGS2(1)	2299258	4	4	4	1	3	0	0	1	0	0	0.588	0.246	0.939
162	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(2), CCNB1(1), CDKN1B(1), CDKN2A(1), CDKN2C(1), RB1(3)	6920181	9	9	9	0	0	3	0	1	5	0	0.136	0.247	0.939
163	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	EPHX2(2), HSD3B7(1)	2068630	3	3	3	1	1	0	0	2	0	0	0.731	0.254	0.955
164	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	HGD(2)	955265	2	2	2	1	0	0	0	1	1	0	0.941	0.254	0.955
165	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	EGF(3), EGFR(21), ETS1(1), FOS(1), HOXA7(1), MAP2K3(1), MAP2K6(1), MAP3K1(2), MAP3K5(2), MAPK1(1), MAPK8(1), NFKBIA(1), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(1), RAF1(1), RIPK1(1), TNF(1)	21177733	43	38	37	7	8	16	1	12	6	0	0.0165	0.265	0.989
166	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(1), FOS(1), IL6(1), IL6ST(2), JAK2(1), JAK3(1), PTPN11(5), RAF1(1), SHC1(1), SRF(1), STAT3(1)	10315618	16	16	15	3	1	4	0	8	3	0	0.290	0.275	1.000
167	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADS(2), ECHS1(1), HADHA(2)	2323924	5	5	5	2	1	1	0	1	2	0	0.642	0.282	1.000
168	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ASL(1), CPS1(2), GLUD1(2)	3364346	5	4	5	1	0	0	0	2	3	0	0.813	0.283	1.000
169	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), HLA-DRA(1)	1022309	2	2	2	0	1	0	0	1	0	0	0.573	0.285	1.000
170	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(1), HDC(2), TH(1)	2613399	4	4	4	1	2	1	0	1	0	0	0.510	0.304	1.000
171	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	HK1(3), PFKL(1), PGK1(1), PKLR(1)	4009994	6	6	6	0	2	3	0	0	1	0	0.0839	0.315	1.000
172	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALML3(1), DGKA(1), DGKD(2), DGKH(1), DGKQ(1), FN3K(1), INPP4B(1), INPPL1(1), ITPR1(2), ITPR2(4), ITPR3(4), OCRL(2), PI4KA(2), PI4KB(2), PIK3C2B(1), PIK3CA(28), PIK3CG(2), PIK3R1(14), PIK3R5(1), PIP4K2B(1), PIP4K2C(2), PLCB1(2), PLCB2(3), PLCB4(1), PLCD3(2), PLCE1(3), PLCG1(4), PLCG2(4), PLCZ1(1), PRKCA(1), PRKCG(1), PTEN(13), PTPMT1(1), SYNJ1(1), SYNJ2(3)	53729361	114	92	99	16	21	37	4	23	29	0	0.000607	0.332	1.000
173	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	DPYS(2), ENPP1(1), ENPP3(2), ILVBL(1), PANK2(1), PANK4(1), VNN1(1)	7451094	9	9	9	0	2	1	0	1	5	0	0.172	0.332	1.000
174	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(1), CA1(1), CA12(1), CA5A(1), CPS1(2), GLUD1(2), HAL(1)	8183484	9	9	9	1	2	1	1	3	2	0	0.290	0.335	1.000
175	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1), GLUD1(2)	2380799	3	3	3	1	0	0	0	3	0	0	0.811	0.337	1.000
176	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(1), IDI1(1)	1820386	2	2	2	0	0	1	0	0	1	0	0.660	0.342	1.000
177	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	TAT(1)	1134964	1	1	1	1	0	0	1	0	0	0	0.909	0.354	1.000
178	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(1), EEF1D(2), EIF1AX(4), EIF2AK3(1), EIF2B4(1), EIF2S2(1), EIF4A1(2), EIF4A2(1), EIF4G1(3), EIF4G3(3), GSPT2(2), KIAA0664(5), PABPC1(2)	18921187	28	25	27	4	7	6	2	6	7	0	0.0752	0.355	1.000
179	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	GAD2(1), GGT1(2)	2482497	3	3	3	0	2	1	0	0	0	0	0.290	0.356	1.000
180	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(1), FOS(1), JAK2(1), MAPK8(1), PLCG1(4), RAF1(1), SHC1(1), STAT5B(1)	9265220	11	11	10	1	0	6	0	2	3	0	0.111	0.359	1.000
181	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(4), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), LDHA(1), LDHB(1), PC(1), PCK1(1), PDHA1(3), PDHA2(2), PDHB(1), PKLR(1)	15944748	23	23	23	3	7	9	0	4	3	0	0.0327	0.359	1.000
182	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	CHAT(1), DBH(1), DDC(1), GAD2(1), HDC(2), PAH(1), TH(1)	6224415	8	8	8	1	4	1	0	1	2	0	0.242	0.359	1.000
183	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CXCR4(1), FOS(1), MAPK8(1), PLCG1(4), PRKCA(1), PTK2B(1)	5942948	9	9	8	2	1	6	1	0	1	0	0.303	0.361	1.000
184	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	AGPAT2(1), AGPAT3(1), AGPS(1), CHAT(1), DGKA(1), DGKD(2), DGKH(1), DGKQ(1), GNPAT(1), LGALS13(2), LYPLA1(1), PAFAH1B1(2), PAFAH2(1), PLA2G3(1), PLA2G4A(4), PLCB2(3), PLCG1(4), PLCG2(4)	21556210	32	31	31	4	10	10	1	5	6	0	0.0291	0.362	1.000
185	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	CARD11(3), CD22(2), CR2(2), FOS(1), IFITM1(1), KRAS(1), LILRB3(2), NFAT5(2), NFATC1(1), NFATC2(2), NFATC4(1), NFKBIA(1), NRAS(1), PIK3CA(28), PIK3CG(2), PIK3R1(14), PIK3R5(1), PLCG2(4), PPP3R2(1), RAC2(1), VAV1(3), VAV3(8)	32059436	82	66	61	15	15	25	3	11	28	0	0.0219	0.363	1.000
186	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(3), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH3B2(1), ALDH7A1(1), CNDP1(1), DDC(1), FTCD(3), HAL(1), HARS(1), HDC(2), PRMT5(2), PRMT8(1), PRPS1(1), PRPS2(1)	17087446	25	25	25	4	14	4	2	2	3	0	0.0373	0.377	1.000
187	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	HLA-DRA(1), IL12B(1), IL15(1), IL6(1), PDGFA(1), TNF(1)	5660428	6	6	6	1	1	2	1	2	0	0	0.361	0.390	1.000
188	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	DPYS(2), ENPP1(1), ENPP3(2), PANK2(1), PANK4(1)	6002900	7	7	7	0	2	1	0	0	4	0	0.247	0.391	1.000
189	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(1), GALNT4(1), GALNT6(1), ST3GAL1(1), ST3GAL4(1), WBSCR17(4)	6220936	9	9	9	2	4	1	1	2	1	0	0.451	0.421	1.000
190	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	FUT8(1), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1)	3403392	4	4	4	1	2	1	1	0	0	0	0.541	0.422	1.000
191	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(1), ADRB2(1), CFTR(3), GNAS(3), PRKACG(1), PRKAR1A(2)	5651014	11	11	11	3	4	3	0	2	2	0	0.577	0.428	1.000
192	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(1), FUT5(1), ST3GAL3(1)	2187968	3	3	3	0	1	1	0	0	1	0	0.425	0.430	1.000
193	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ADCY1(1), CCNB1(1), GNAI1(3), GNAS(3), MAPK1(1), MYT1(2), PRKACG(1), PRKAR1A(2), RPS6KA1(1)	8874125	15	15	15	3	3	3	0	4	5	0	0.426	0.431	1.000
194	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	UXS1(2)	1644272	2	2	2	1	0	1	0	0	1	0	0.900	0.432	1.000
195	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR2(2), PDE1A(1), PDE1B(1), PLCB1(2), PLCB2(3)	4807619	9	9	9	3	3	2	0	2	2	0	0.632	0.453	1.000
196	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), CYP4F3(4), GGT1(2), LPO(3), LTA4H(1), MPO(2), PLA2G3(1), PLA2G4A(4), PTGES2(1), PTGS1(1), PTGS2(1), TPO(3)	12053396	25	24	25	5	10	5	0	6	4	0	0.111	0.458	1.000
197	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	CREBBP(4), DTX1(1), DVL2(1), HDAC2(3), MAML1(2), MAML2(2), MFNG(1), NCOR2(3), NCSTN(1), NOTCH1(33), NOTCH2(5), NOTCH3(4), NOTCH4(5), NUMBL(2), RBPJ(4), RBPJL(1)	30030744	72	60	66	14	11	12	1	14	31	3	0.225	0.461	1.000
198	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ANGPTL2(1), ARHGEF6(2), BRAF(3), CDKN2A(1), DOCK1(1), GRB7(1), ITGA10(1), ITGA11(2), ITGA2(1), ITGA4(1), ITGA5(1), ITGA8(1), MAPK1(1), MAPK8(1), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1), MYLK(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PIK3CA(28), PKLR(1), PLCG1(4), PLCG2(4), PTEN(13), RAF1(1), RALA(1), ROCK2(1), SHC1(1), SOS2(1), TLN1(3), TLN2(1), WAS(2)	52724720	87	70	74	10	12	27	3	25	20	0	0.000242	0.461	1.000
199	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(1), CDC25B(1), SHH(1), XPO1(1)	3734420	4	4	4	0	1	3	0	0	0	0	0.205	0.464	1.000
200	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	DLG4(1), F2(3), F2RL1(2), MAP2K5(1), MAPK1(1), MAPK7(3), MAPK8(1), PLD1(3), RAF1(1), RASAL1(1), TEC(1), VAV1(3)	11848811	21	19	21	4	5	5	1	6	4	0	0.177	0.471	1.000
201	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(2)	2091986	2	2	2	1	0	2	0	0	0	0	0.739	0.478	1.000
202	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(1), FUCA1(1), FUCA2(2), HEXA(1), LCT(2), MAN2C1(1), NEU1(1), NEU2(2)	7140484	11	11	11	3	3	2	1	3	2	0	0.545	0.483	1.000
203	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	LPO(3), MPO(2), MTHFR(1), TPO(3)	4999800	9	8	9	2	5	2	0	2	0	0	0.341	0.485	1.000
204	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	CREBBP(4), PRF1(1)	4558722	5	5	5	1	2	1	0	1	1	0	0.600	0.485	1.000
205	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(2), APOBEC4(1)	3154212	3	3	3	1	0	1	0	1	1	0	0.703	0.488	1.000
206	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNAS(3), PRKACG(1), PRKAR1A(2), PRKCA(1)	4147641	7	7	7	2	3	0	0	2	2	0	0.792	0.498	1.000
207	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(1), DDIT3(1), MAP2K6(1), MAP3K1(2), MAP3K5(2), MAPKAPK5(2), MAX(3), MKNK1(1), PLA2G4A(4), RIPK1(1), SHC1(1), TGFBR1(1), TRADD(1)	15799654	21	20	20	3	4	9	0	5	3	0	0.106	0.503	1.000
208	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	LPO(3), MPO(2), TPO(3)	5090866	8	7	8	2	5	2	0	1	0	0	0.368	0.504	1.000
209	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), HLA-DRA(1)	1711473	2	2	2	0	1	0	0	1	0	0	0.584	0.511	1.000
210	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	MARCKS(1), NFATC1(1), NFATC2(2), NFATC4(1), PLCG1(4), PRKCA(1), SP3(2)	9029438	12	12	11	2	3	4	0	1	4	0	0.264	0.520	1.000
211	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	HLA-DRA(1)	1311478	1	1	1	1	0	0	0	1	0	0	0.945	0.520	1.000
212	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(2), ACE2(1), AGTR2(1), CMA1(1), CTSG(1), ENPEP(4), NLN(1), REN(1), THOP1(1)	9136516	13	13	13	3	4	3	0	3	3	0	0.359	0.524	1.000
213	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT2(1)	1454369	1	1	1	0	0	0	0	1	0	0	0.819	0.532	1.000
214	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	SNCA(1), SNCAIP(1), UBE2G2(1)	2775440	3	3	3	0	3	0	0	0	0	0	0.282	0.533	1.000
215	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GGT1(2)	1793900	2	2	2	0	1	1	0	0	0	0	0.440	0.542	1.000
216	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(4), PRKCA(1), PTK2B(1)	2902475	7	7	6	3	2	4	0	0	1	0	0.636	0.551	1.000
217	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	C1GALT1(1), GALNT1(1), GALNT14(1), GALNT4(1), GALNT5(1), GALNT6(1), GALNTL1(1), GALNTL4(1), GALNTL5(1), OGT(5), ST3GAL1(1), ST6GALNAC1(1), WBSCR17(4)	13919571	20	20	20	4	5	5	1	5	4	0	0.325	0.555	1.000
218	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	UXS1(2)	2097000	2	2	2	1	0	1	0	0	1	0	0.901	0.555	1.000
219	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(1), PLCB1(2)	3080286	3	3	3	1	0	0	0	2	1	0	0.755	0.556	1.000
220	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(1)	912723	1	1	1	0	0	0	0	1	0	0	0.810	0.562	1.000
221	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	CXCL9(1), FOS(1), IFNA21(1), IFNA5(1), IFNAR1(2), IKBKE(2), IL12B(1), IL6(1), IRAK4(1), LBP(1), MAP2K3(1), MAP2K6(1), MAPK1(1), MAPK12(1), MAPK8(1), MAPK9(1), NFKBIA(1), PIK3CA(28), PIK3CG(2), PIK3R1(14), PIK3R5(1), RIPK1(1), SPP1(1), TBK1(1), TICAM1(1), TLR1(3), TLR2(1), TLR3(1), TLR5(1), TLR6(2), TLR7(2), TLR9(2), TNF(1), TOLLIP(1)	38698773	82	71	68	15	11	31	4	14	22	0	0.0101	0.562	1.000
222	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	FOS(1), MAPK1(1), MAPK8(1), PRKCA(1)	3834844	4	4	4	1	1	3	0	0	0	0	0.455	0.563	1.000
223	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1)	1686724	1	1	1	0	0	0	0	1	0	0	0.818	0.568	1.000
224	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(1), PRKCA(1)	2138681	2	2	2	1	1	0	0	1	0	0	0.802	0.569	1.000
225	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(2), ICAM1(1), ITGAL(2), ITGB2(1), SELE(3)	4479835	9	9	8	4	6	2	0	0	1	0	0.537	0.570	1.000
226	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(3), LCT(2), PYGL(1)	5792937	6	6	6	1	2	2	0	0	2	0	0.257	0.575	1.000
227	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), MAP3K1(2), MAP3K5(2), MAPK8(1), NFKBIA(1), TNFRSF9(2), TNFSF9(1)	8327115	10	10	10	2	2	4	0	0	4	0	0.396	0.581	1.000
228	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	NR1H3(1), RXRA(1)	2340728	2	2	2	1	0	1	1	0	0	0	0.777	0.581	1.000
229	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), CYP2C19(5), DHRS2(1), DHRSX(1), ECHS1(1), ESCO2(1), HADHA(2)	13301174	19	17	19	3	10	3	0	1	5	0	0.0923	0.583	1.000
230	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG5(3), IFNA21(1), IFNA5(1), PIK3R4(1), PRKAA1(1), ULK2(1)	9096352	8	8	8	1	1	3	0	2	2	0	0.222	0.585	1.000
231	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CFL1(1)	1670598	1	1	1	0	0	0	0	0	1	0	0.659	0.593	1.000
232	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST3A1(1), XYLT1(2)	2861050	3	3	3	0	1	2	0	0	0	0	0.262	0.598	1.000
233	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST3A1(1), XYLT1(2)	2861050	3	3	3	0	1	2	0	0	0	0	0.262	0.598	1.000
234	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(2), ICAM1(1), ITGA4(1), ITGAL(2), ITGB2(1), SELE(3), SELP(1)	6871726	11	11	10	4	6	3	0	1	1	0	0.429	0.605	1.000
235	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(3), CR2(2), HLA-DRA(1), ICAM1(1), ITGAL(2), ITGB2(1), PTPRC(3)	6542998	13	12	13	4	7	2	0	2	2	0	0.373	0.605	1.000
236	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	HLA-DRA(1), PTPRC(3), ZAP70(2)	3895662	6	6	6	2	2	2	0	2	0	0	0.642	0.607	1.000
237	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST3GAL1(1), ST3GAL4(1)	2438625	2	2	2	1	1	0	1	0	0	0	0.859	0.612	1.000
238	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	BRAF(3), CD244(1), FASLG(1), HLA-G(2), ICAM1(1), IFNA21(1), IFNA5(1), IFNAR1(2), IFNGR2(1), ITGAL(2), ITGB2(1), KIR2DL1(3), KLRC2(1), KRAS(1), LAT(1), MAPK1(1), MICA(1), NFAT5(2), NFATC1(1), NFATC2(2), NFATC4(1), NRAS(1), PAK1(1), PIK3CA(28), PIK3CG(2), PIK3R1(14), PIK3R5(1), PLCG1(4), PLCG2(4), PPP3R2(1), PRF1(1), PRKCA(1), PRKCG(1), PTK2B(1), PTPN11(5), RAC2(1), RAF1(1), SH2D1A(1), SH2D1B(1), SH3BP2(1), SHC1(1), SOS2(1), TNF(1), TNFRSF10C(1), ULBP1(1), VAV1(3), VAV3(8), ZAP70(2)	48882094	118	96	95	24	19	37	3	25	34	0	0.0180	0.613	1.000
239	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSS(1), TNF(1), XDH(2)	4275718	4	4	4	1	2	1	0	0	1	0	0.493	0.615	1.000
240	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	FDPS(1), IDI1(1), MVD(1), NSDHL(2)	5685804	5	5	5	0	2	1	0	1	1	0	0.257	0.620	1.000
241	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	CHPF(1), CHST11(1), CHST13(1), CHSY1(1), DSE(1), XYLT1(2)	6090316	7	7	7	1	3	2	0	2	0	0	0.245	0.621	1.000
242	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(4), MAP2(2), PRKACG(1)	7821214	7	7	7	0	0	2	0	0	5	0	0.332	0.622	1.000
243	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(1), BCR(1), FOS(1), MAP3K1(2), MAPK1(1), MAPK8IP3(1), PAPPA(2), RPS6KA1(1), RPS6KA3(1), SHC1(1), VAV1(3), VAV3(8)	13832475	23	23	16	5	3	4	0	7	9	0	0.655	0.632	1.000
244	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(4), PRKAA1(1)	6227744	5	5	5	1	3	2	0	0	0	0	0.422	0.633	1.000
245	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(1), ACACA(4), ACACB(5), ACAT2(1), ACSS1(2), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH6A1(1), ALDH7A1(1), ECHS1(1), HADHA(2), LDHA(1), LDHAL6B(1), LDHB(1)	17105171	27	26	27	5	13	5	0	6	3	0	0.0834	0.638	1.000
246	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	EGF(3), EGFR(21), MAPK1(1), MYLK(1), PRKACG(1), PRKAR1A(2), TLN1(3)	14118939	32	28	26	8	6	9	0	14	3	0	0.324	0.647	1.000
247	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25B(1), WEE1(1)	2943558	2	2	2	1	1	0	0	0	1	0	0.942	0.653	1.000
248	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	CDC25B(1), MYT1(2), WEE1(1), YWHAH(1)	5927391	5	5	5	0	1	0	0	0	4	0	0.409	0.669	1.000
249	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(3)	3629332	3	3	3	0	1	2	0	0	0	0	0.313	0.674	1.000
250	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	HEXA(1), IDS(1), LCT(2), NAGLU(2)	6232259	6	6	6	1	2	2	0	0	2	0	0.391	0.674	1.000
251	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GGT1(2)	2376239	2	2	2	0	1	1	0	0	0	0	0.449	0.679	1.000
252	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(1), BAG4(1), CRADD(1), LMNA(1), LMNB2(1), MADD(1), MAP3K1(2), MAPK8(1), PAK1(1), PRKDC(3), RB1(3), RIPK1(1), SPTAN1(2), TNF(1), TRADD(1)	16624676	21	19	21	3	6	5	1	3	6	0	0.125	0.681	1.000
253	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SRP72(1), SRPR(1)	3246178	2	2	2	1	2	0	0	0	0	0	0.815	0.682	1.000
254	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(2), DAG1(1), ITPR1(2), ITPR2(4), ITPR3(4), NFKBIA(1), PDK1(2), PHKA2(2), PITX2(1), PLD1(3)	19345027	22	22	22	3	6	4	2	9	1	0	0.0903	0.682	1.000
255	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	IL6(1), LPL(1)	2295534	2	2	2	0	0	0	0	2	0	0	0.699	0.687	1.000
256	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFS1(1), NDUFV2(1)	3003480	2	2	2	0	0	0	0	1	1	0	0.832	0.689	1.000
257	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	ABAT(1), ACADS(2), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ECHS1(1), GAD2(1), HADHA(2), L2HGDH(1), PDHA1(3), PDHA2(2), PDHB(1)	11125911	22	21	22	6	7	5	0	4	6	0	0.205	0.690	1.000
258	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B4GALNT1(1), HEXA(1), LCT(2), SLC33A1(1), ST3GAL1(1), ST6GALNAC3(1), ST8SIA5(1)	7099090	8	8	8	2	4	0	1	1	2	0	0.597	0.704	1.000
259	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS2(1), PPOX(1)	3284851	2	2	2	1	0	1	0	1	0	0	0.805	0.709	1.000
260	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	LDHA(1), LDHB(1), NCL(1)	3852719	3	3	3	0	0	1	0	1	1	0	0.562	0.710	1.000
261	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(1), HADHA(2)	2085196	3	3	3	3	0	1	0	1	1	0	0.924	0.712	1.000
262	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	LDHA(1), LDHB(1)	2949177	2	2	2	0	0	1	0	1	0	0	0.563	0.714	1.000
263	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP9(1), RECK(1), TIMP4(1)	3249643	3	3	3	1	2	0	0	0	1	0	0.644	0.719	1.000
264	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	HEXA(1), HYAL1(1), IDS(1), LCT(2), NAGLU(2), SPAM1(1)	8863126	8	8	8	1	3	2	0	1	2	0	0.278	0.720	1.000
265	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	P2RY2(1), P2RY6(1)	2572781	2	2	2	1	1	1	0	0	0	0	0.716	0.722	1.000
266	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CD28(1), CTLA4(1), DAG1(1), FBXW7(1), LAT(1), MAPK1(1), NCK1(1), NFAT5(2), NFKBIA(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PLCG1(4), PTPRC(3), RAF1(1), RASGRP2(1), RASGRP4(1), SOS2(1), VAV1(3), ZAP70(2)	24023237	30	26	29	3	9	11	0	4	6	0	0.00813	0.723	1.000
267	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	MST1(3), TNF(1)	2826765	4	4	4	2	1	2	0	0	1	0	0.701	0.725	1.000
268	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	CYP11A1(1), CYP11B1(1), HSD3B2(1)	3988391	3	3	3	0	1	0	0	2	0	0	0.478	0.734	1.000
269	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	CYP11A1(1), CYP11B1(1), HSD3B2(1)	3988391	3	3	3	0	1	0	0	2	0	0	0.478	0.734	1.000
270	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(1), CREBBP(4), GNAS(3), HLA-DRA(1), PRKACG(1), PRKAR1A(2), PTPRC(3), ZAP70(2)	9917795	17	16	17	4	6	3	0	5	3	0	0.484	0.735	1.000
271	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(1), CREBBP(4), GNAS(3), HLA-DRA(1), PRKACG(1), PRKAR1A(2), PTPRC(3), ZAP70(2)	9917795	17	16	17	4	6	3	0	5	3	0	0.484	0.735	1.000
272	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	LDHA(1), LDHAL6B(1), LDHB(1), SULT1C2(1)	5405420	4	4	4	1	1	1	0	1	1	0	0.676	0.743	1.000
273	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(1), GNAS(3), PRKAA1(1), PRKACG(1), PRKAR1A(2)	6623564	8	8	8	2	4	0	0	2	2	0	0.689	0.744	1.000
274	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(3), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH3B2(1), CNDP1(1), DDC(1), HAL(1), HARS(1), HDC(2), PRPS1(1), PRPS2(1)	10532488	19	18	19	5	11	3	1	2	2	0	0.209	0.745	1.000
275	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	FBP2(1), G6PC(3), HK1(3), HK3(1), LDHA(1), LDHAL6B(1), LDHB(1), PC(1), PCK1(1), PDHA1(3), PDHA2(2), PDHB(1), PFKL(1), PGAM2(1), PGK1(1), PKLR(1)	18321219	23	22	23	3	6	11	0	4	2	0	0.0208	0.746	1.000
276	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1)	1679431	1	1	1	1	0	1	0	0	0	0	0.890	0.751	1.000
277	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD28(1)	1382645	1	1	1	1	1	0	0	0	0	0	0.903	0.753	1.000
278	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(1), COL4A4(1), COL4A5(3), COL4A6(3), F2(3), F5(4), F8(3), FGA(1), FGB(1), FGG(1), KLKB1(3), PROS1(1), SERPING1(2)	19133764	27	26	27	6	10	8	1	3	5	0	0.104	0.762	1.000
279	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(2), PRKACG(1)	4350880	3	3	3	1	0	1	0	1	1	0	0.819	0.765	1.000
280	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), RIPK1(1), TNF(1), TRADD(1)	3632122	4	4	4	2	1	1	0	1	1	0	0.818	0.766	1.000
281	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	HEXA(1), ST3GAL1(1), ST3GAL4(1)	4366757	3	3	3	1	1	0	1	0	1	0	0.792	0.769	1.000
282	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(1), CDC25B(1), PRKCA(1)	3971069	3	3	3	1	2	1	0	0	0	0	0.600	0.773	1.000
283	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADS(2), ACADVL(1), ACSL1(3), ACSL4(1), HADHA(2), PECR(1)	7247921	10	10	10	3	1	3	0	2	4	0	0.578	0.775	1.000
284	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	FARS2(2), PAH(1), TAT(1)	3575269	4	4	4	2	1	1	1	0	1	0	0.812	0.776	1.000
285	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(1), JAK2(1), TYK2(2)	4519814	5	5	5	2	1	0	1	0	3	0	0.716	0.777	1.000
286	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(1), JAK2(1), TYK2(2)	4519814	5	5	5	2	1	0	1	0	3	0	0.716	0.777	1.000
287	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS2(1), DHRSX(1), HSD3B7(1), PON1(2)	3872099	5	5	5	2	1	1	0	1	2	0	0.782	0.780	1.000
288	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	DHRS2(1), DHRSX(1), PRMT5(2), PRMT8(1)	6472756	5	5	5	0	1	3	1	0	0	0	0.140	0.787	1.000
289	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	IARS2(1), ILVBL(1), LARS(1), PDHA1(3), PDHA2(2), PDHB(1)	8019112	9	9	9	2	0	4	0	3	2	0	0.440	0.787	1.000
290	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(4), ACACB(5), FASN(1), OXSM(1)	6885313	11	11	11	4	5	3	0	1	2	0	0.524	0.792	1.000
291	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	FDPS(1), IDI1(1), MVD(1)	4771411	3	3	3	0	0	1	0	1	1	0	0.550	0.796	1.000
292	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	HK1(3), HK3(1), PGM3(1)	4410998	5	5	5	2	0	3	0	1	1	0	0.626	0.798	1.000
293	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	CREB3(3), IL1R1(1), MAP2K3(1), MAP2K6(1), MAP3K10(1), MAP3K4(2), MAP3K5(2), MAPK1(1), MAPK12(1), MAPKAPK5(2), MKNK1(1), SRF(1)	14388816	17	17	17	4	1	7	0	5	4	0	0.496	0.800	1.000
294	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(1)	1627024	1	1	1	0	1	0	0	0	0	0	0.612	0.800	1.000
295	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	RAB27A(1)	1818191	1	1	1	0	1	0	0	0	0	0	0.642	0.802	1.000
296	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	HK1(3), HK3(1), ISYNA1(1), PGM3(1)	5043619	6	6	6	2	0	4	0	1	1	0	0.507	0.802	1.000
297	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	GGT1(2), MARS2(1), SCLY(1)	5336322	4	4	4	1	1	2	1	0	0	0	0.464	0.802	1.000
298	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(2), ATP6V1C2(1), ATP6V1D(1), ATP7A(1), COX7B(1), NDUFS1(1), NDUFV2(1), SDHA(3), UQCRC1(1), UQCRH(1)	16441971	13	13	12	0	4	5	0	3	1	0	0.0172	0.807	1.000
299	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(1), CREB3(3), DAG1(1), FOS(1), MAPK1(1), MAPK8(1), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1)	12366981	11	11	11	0	1	4	0	3	3	0	0.0750	0.807	1.000
300	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CYP11A1(1), HSD3B2(1)	2975165	2	2	2	1	1	0	0	1	0	0	0.875	0.808	1.000
301	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(1), PRKCA(1)	3885763	2	2	2	1	1	0	0	1	0	0	0.823	0.808	1.000
302	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR2(1), JAK2(1)	3515158	2	2	2	2	0	0	0	0	2	0	0.965	0.812	1.000
303	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(3)	2604049	3	3	3	2	2	1	0	0	0	0	0.806	0.812	1.000
304	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(1), ACAD9(1), ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), DHRS2(1), DHRSX(1), ESCO2(1)	10743125	10	10	10	2	2	2	0	4	2	0	0.406	0.814	1.000
305	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(2), PAH(1), TAT(1)	3748069	4	4	4	2	1	1	1	0	1	0	0.819	0.815	1.000
306	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(1), CA1(1), CA12(1), CA5A(1), CPS1(2), GLUD1(2), GLUD2(1), HAL(1)	9149707	10	10	10	3	2	2	1	3	2	0	0.580	0.816	1.000
307	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	MAP2K3(1), MAP3K1(2), MAPK1(1), MAPK8(1), PAK1(1), PLCG1(4), PRKCA(1), PTK2B(1), RAF1(1), SHC1(1)	12303490	14	14	13	3	3	7	0	1	3	0	0.249	0.818	1.000
308	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2E1(1), GTF2H4(1), GTF2IRD1(1), TAF1(4), TAF1L(2), TAF2(1), TAF4(1), TAF6(1), TAF9B(1), TBPL2(1)	15500100	14	14	14	2	5	3	0	4	2	0	0.182	0.822	1.000
309	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(1), FOS(1), JAK2(1), RAF1(1), SHC1(1), STAT5B(1)	7612079	6	6	6	1	0	1	0	2	3	0	0.485	0.824	1.000
310	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(1), ADRB2(1), GNAS(3), PLCE1(3), PRKACG(1), PRKAR1A(2), RAP2B(1)	6371572	12	12	12	4	4	2	0	3	3	0	0.763	0.829	1.000
311	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHA4(3), L1CAM(1), SELP(1)	6795425	5	5	5	1	2	1	0	2	0	0	0.538	0.830	1.000
312	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), UBE2G2(1), UBE2M(1)	4537963	3	3	3	1	1	1	0	0	1	0	0.813	0.830	1.000
313	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(2), ANXA2(2), ANXA3(1), ANXA6(1), CYP11A1(1), PLA2G4A(4), PTGS1(1), PTGS2(1)	8878976	13	13	13	4	4	3	1	4	1	0	0.459	0.830	1.000
314	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMPR1B(1)	2711112	1	1	1	2	0	0	0	0	1	0	1.000	0.831	1.000
315	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	DAG1(1)	2626253	1	1	1	0	0	1	0	0	0	0	0.655	0.838	1.000
316	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(1)	2116549	1	1	1	0	1	0	0	0	0	0	0.682	0.843	1.000
317	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), FAF1(1), LMNA(1), LMNB2(1), MAP3K1(2), MAPK8(1), PAK1(1), PRKDC(3), RB1(3), SPTAN1(2)	17421833	16	15	16	2	3	4	1	2	6	0	0.178	0.850	1.000
318	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(2), ALOX12B(1), CYP2B6(1), CYP2C19(5), CYP2C8(1), CYP4A11(1), CYP4A22(1), CYP4F3(4), EPHX2(2), GGT1(2), GPX2(1), LTA4H(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PTGES2(1), PTGS1(1), PTGS2(1)	16802858	32	30	32	7	12	6	0	9	5	0	0.119	0.850	1.000
319	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), ECHS1(1), HADHA(2), HSD17B4(2)	3650855	6	6	6	3	0	2	0	2	2	0	0.836	0.852	1.000
320	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADCY9(2), CACNA1D(1), CACNA1F(3), CACNA1S(5), CALML3(1), EGFR(21), GNAS(3), GNRHR(1), HBEGF(1), ITPR1(2), ITPR2(4), ITPR3(4), KRAS(1), MAP2K3(1), MAP2K6(1), MAP3K1(2), MAP3K4(2), MAPK1(1), MAPK12(1), MAPK7(3), MAPK8(1), MAPK9(1), NRAS(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PLCB1(2), PLCB2(3), PLCB4(1), PLD1(3), PRKACG(1), PRKCA(1), PTK2B(1), RAF1(1), SOS2(1)	54977075	92	74	86	13	24	25	2	27	14	0	0.000490	0.855	1.000
321	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	CRADD(1), MAP2K3(1), MAP2K6(1), MAP3K1(2), MAPK8(1), NFKBIA(1), RIPK1(1), TANK(2), TNF(1), TRADD(1)	10446813	12	12	12	3	5	4	0	0	3	0	0.308	0.858	1.000
322	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	PTK2B(1), SHC1(1)	3807867	2	2	2	1	0	1	0	1	0	0	0.813	0.859	1.000
323	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASDHPPT(1)	2035737	1	1	1	0	0	0	0	0	1	0	0.719	0.861	1.000
324	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(1)	2647639	1	1	1	1	0	1	0	0	0	0	0.880	0.865	1.000
325	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR6(1)	2763690	1	1	1	0	0	1	0	0	0	0	0.676	0.869	1.000
326	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT2(1)	3086050	1	1	1	0	0	0	0	1	0	0	0.823	0.871	1.000
327	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	BAX(1), CASP8AP2(1)	4641159	2	2	2	0	0	0	0	0	2	0	0.691	0.871	1.000
328	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	FOS(1), MAP2K3(1), MAP2K6(1), MAP3K1(2), MAPK8(1), NFKBIA(1), TLR10(1), TLR2(1), TLR3(1), TLR6(2), TLR7(2), TLR9(2), TOLLIP(1)	15759099	17	17	17	4	7	4	0	3	3	0	0.272	0.873	1.000
329	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1B(1), ADRB2(1), CHRM1(1), CHRM3(3), CHRM5(1), DRD5(3), HRH1(1), HTR1B(2), HTR1E(1), HTR2A(1), HTR2B(2), HTR4(1), HTR5A(1)	11095685	19	18	19	5	8	3	0	3	5	0	0.261	0.874	1.000
330	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	GRIN1(1), JAK2(1), NFKBIA(1)	5465414	3	3	3	1	0	0	0	0	3	0	0.749	0.880	1.000
331	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(2), ENPP1(1), ENPP3(2), NADSYN1(1), NNMT(1), NT5C(2), NT5E(1)	9271810	10	10	10	3	1	6	1	1	1	0	0.437	0.881	1.000
332	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	CHRM1(1), CHRNA1(2), FLT4(1), KDR(4), NOS3(3), PDE2A(1), PDE3A(1), PRKACG(1), PRKAR1A(2), PRKG2(1), RYR2(10), TNNI1(1)	17456491	28	27	28	7	8	7	1	7	5	0	0.190	0.882	1.000
333	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(3), CACNA1A(2), CACNA1B(4), GNAS(3), GRM4(3), ITPR3(4), KCNB1(3), PDE1A(1), PLCB2(3), PRKACG(1), SCNN1B(1), TAS1R2(2), TAS1R3(1), TAS2R1(2), TAS2R16(2), TAS2R4(2), TAS2R40(2), TAS2R41(1), TAS2R9(1), TRPM5(1)	24573015	42	39	42	9	17	7	1	10	7	0	0.123	0.882	1.000
334	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(4), LPL(1), NCOA1(1), NCOA2(1), PPARG(1), RXRA(1)	7953781	9	9	9	3	1	4	0	3	1	0	0.628	0.883	1.000
335	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(3), ABCB4(3), ABCC3(1)	6171322	7	7	7	3	1	1	1	2	2	0	0.825	0.885	1.000
336	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS2(1), CPO(1)	3415162	2	2	2	2	0	1	0	0	1	0	0.881	0.891	1.000
337	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(2), PTPRU(1), REG1A(1), TYK2(2)	5388859	6	6	6	3	1	1	0	1	3	0	0.862	0.893	1.000
338	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(1), FOS(1), THBS1(1)	3184347	3	3	3	2	0	2	0	0	1	0	0.800	0.894	1.000
339	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACPP(3), ALPP(4), ALPPL2(2), CYP1A2(2), CYP2B6(1), CYP2C19(5), CYP2C8(1), CYP3A4(2), CYP3A7(1), CYP4F8(1), PON1(2)	12603661	24	21	24	6	12	3	0	3	6	0	0.299	0.895	1.000
340	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AP2M1(1), BIN1(1), SYNJ1(1), SYNJ2(3)	9282683	6	6	6	1	2	2	0	1	1	0	0.409	0.895	1.000
341	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT2(1), ECHS1(1), HADHA(2)	3360048	4	4	4	4	0	1	0	2	1	0	0.952	0.896	1.000
342	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(6), C6(1), C7(2), C8A(2)	5386542	11	11	11	6	5	2	0	1	3	0	0.791	0.898	1.000
343	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(2), TYK2(2)	4669623	4	4	4	3	1	0	0	1	2	0	0.952	0.899	1.000
344	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	FOS(1), POLR2A(1), PRKACG(1), PRKAR1A(2)	5563314	5	5	5	2	2	1	0	1	1	0	0.781	0.900	1.000
345	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	IL1R1(1), IL6(1), IRAK3(1), MAP2K3(1), MAP2K6(1), MAP3K1(2), MAPK8(1), NFKBIA(1), TNF(1), TOLLIP(1)	12794546	11	11	11	2	3	5	0	1	2	0	0.194	0.900	1.000
346	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	CHST11(1), CHST13(1), SULT2B1(2)	3959948	4	3	4	2	1	0	0	2	1	0	0.865	0.900	1.000
347	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(1), FOS(1), GNAI1(3), GNAS(3), NFATC1(1), NFATC2(2), NFATC4(1), PLCG1(4), PRKACG(1), PRKAR1A(2), PRKCA(1), RAF1(1), RPS6KA3(1)	15077643	22	22	21	5	6	5	0	5	6	0	0.320	0.902	1.000
348	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ARPC1B(1)	3494857	1	1	1	1	0	1	0	0	0	0	0.899	0.904	1.000
349	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BRAF(3), CREB3(3), MAPK1(1), MKNK1(1), RPS6KA1(1), RPS6KA3(1), SHC1(1), SOS2(1)	12728816	12	12	12	3	0	3	0	6	3	0	0.658	0.906	1.000
350	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIA(1), GFPT1(1), GFPT2(2), GNPDA1(1), HEXA(1), HK1(3), HK3(1), MTMR6(1), PGM3(1), RENBP(3)	12384265	15	15	15	4	2	6	0	4	3	0	0.432	0.906	1.000
351	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(1), ACAT2(1), ECHS1(1), HADHA(2)	3600996	5	5	5	3	0	2	0	2	1	0	0.833	0.907	1.000
352	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	HEXA(1), ST3GAL1(1)	4634004	2	2	2	1	0	0	1	0	1	0	0.919	0.907	1.000
353	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(1), ABP1(3), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), CNDP1(1), DPYS(2), ECHS1(1), GAD2(1), HADHA(2)	11632891	18	17	18	5	9	2	0	2	5	0	0.308	0.908	1.000
354	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	FDPS(1), IDI1(1), MVD(1), NSDHL(2)	8309818	5	5	5	1	2	1	0	1	1	0	0.555	0.908	1.000
355	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(2), CD44(2), TNF(1), TNFSF8(1)	5664869	6	6	6	3	2	3	0	0	1	0	0.711	0.909	1.000
356	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ECHS1(1), HADHA(2)	5245847	10	10	10	5	4	2	0	1	3	0	0.689	0.912	1.000
357	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	GFPT1(1), GNPDA1(1), HEXA(1), HK1(3), HK3(1), PGM3(1), RENBP(3)	7320472	11	11	11	4	1	5	0	3	2	0	0.613	0.913	1.000
358	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	PRMT5(2), PRMT8(1)	6064239	3	3	3	0	0	2	1	0	0	0	0.317	0.913	1.000
359	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	DNMT1(1), DNMT3A(4), DNMT3B(1), MARS2(1)	7506034	7	7	7	2	2	2	0	2	1	0	0.471	0.914	1.000
360	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(1), ADCY3(1), ADCY9(2), ATP6V0A2(1), ATP6V1C2(1), ATP6V1D(1), ERO1L(1), GNAS(3), PLCG1(4), PLCG2(4), PRKCA(1)	15919630	20	19	19	4	10	5	0	2	3	0	0.181	0.915	1.000
361	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(1), EXT2(1), EXTL1(2), HS3ST3A1(1), HS6ST2(2), NDST2(1), NDST3(2)	8957134	10	10	10	3	4	1	1	3	1	0	0.499	0.917	1.000
362	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	APC(1), DAG1(1), DLG4(1), GNAI1(3), ITPR1(2), ITPR2(4), ITPR3(4), MAPK1(1), PITX2(1), PTX3(1), RYR1(7)	19746251	26	24	26	5	4	8	2	8	4	0	0.138	0.920	1.000
363	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	GGT1(2), MARS2(1), PRMT5(2), PRMT8(1), SCLY(1)	10751059	7	7	7	1	1	4	2	0	0	0	0.206	0.921	1.000
364	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	MAP3K1(2), NFATC1(1), NFATC2(2), NFKBIA(1), PLCG1(4), PRKACG(1), PRKAR1A(2)	12065408	13	12	12	3	3	4	0	2	4	0	0.350	0.929	1.000
365	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(4), MAP2K3(1), MAP2K6(1), NFKBIA(1), NR3C1(1), TGFBR1(1), TGFBR2(1), TLR2(1), TNF(1)	12817917	12	12	12	3	3	4	0	2	3	0	0.386	0.930	1.000
366	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(1), IL6(1), JAK2(1), JAK3(1), PIAS3(1), PTPRU(1), REG1A(1), STAT3(1)	6582758	8	8	8	3	2	1	0	3	2	0	0.671	0.931	1.000
367	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(1), FTCD(3), GART(1), MTHFR(1)	8151769	6	6	6	2	3	0	0	1	2	0	0.635	0.933	1.000
368	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(4), NCOA3(1), PRKACG(1), PRKAR1A(2), RXRA(1)	8917003	9	9	9	3	2	2	0	2	3	0	0.748	0.934	1.000
369	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSD(1), ARSE(1), GALC(1), LCT(2), NEU1(1), NEU2(2), SMPD2(1)	10453589	9	9	9	2	5	0	0	3	1	0	0.458	0.939	1.000
370	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	ETS1(1), ETV3(1), FOS(1), HDAC2(3), HDAC5(1), NCOR2(3), SIN3A(2)	11250231	12	11	12	3	2	1	1	1	7	0	0.716	0.942	1.000
371	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	BAX(1), CYCS(1)	5773392	2	2	2	0	0	0	0	1	1	0	0.589	0.942	1.000
372	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(1), DHRSX(1), ESCO2(1)	7119953	3	3	3	0	1	1	0	0	1	0	0.462	0.943	1.000
373	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	ICAM1(1), ITGAL(2), ITGB2(1), PRF1(1)	3774024	5	4	5	4	4	0	0	0	1	0	0.858	0.944	1.000
374	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDHPPT(1)	2997755	1	1	1	0	0	0	0	0	1	0	0.705	0.944	1.000
375	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKBIA(1), PLCB1(2), PRKCA(1)	3553840	4	4	4	3	1	0	0	2	1	0	0.905	0.948	1.000
376	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK2(1), JAK3(1), MAPK1(1), STAT3(1), TYK2(2)	5083239	6	6	6	3	2	1	0	1	2	0	0.817	0.950	1.000
377	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	MAF(1), MAP2K3(1), NFATC1(1), NFATC2(2), PRKACG(1), PRKAR1A(2)	5267777	8	8	8	4	3	0	0	3	2	0	0.780	0.950	1.000
378	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), HLA-DRA(1), IFNGR2(1), IL12B(1), IL12RB1(1), IL18(2), IL4R(1)	5454629	8	8	8	5	2	0	1	3	2	0	0.905	0.950	1.000
379	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(1), JAK2(1), PTPRU(1), REG1A(1)	4913825	4	4	4	3	1	1	0	0	2	0	0.877	0.950	1.000
380	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	ECHS1(1), HADHA(2), HSD17B4(2)	5103202	5	5	5	3	0	1	0	2	2	0	0.904	0.951	1.000
381	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	ABAT(1), ACADS(2), ACAT2(1), ACSM1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), ECHS1(1), GAD2(1), HADHA(2), HSD17B4(2), HSD3B7(1), ILVBL(1), L2HGDH(1), PDHA1(3), PDHA2(2), PDHB(1)	17482181	27	26	27	7	8	4	0	7	8	0	0.222	0.952	1.000
382	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CLOCK(1), PER1(2)	3683670	3	3	3	3	0	1	0	1	1	0	0.971	0.952	1.000
383	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(1), CDH1(1), CREBBP(4), TGFBR1(1), TGFBR2(1)	11063197	8	8	8	2	3	2	0	2	1	0	0.520	0.953	1.000
384	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADCY9(2), EGF(3), EGFR(21), GJA1(1), GNAI1(3), GNAS(3), GRM5(1), GUCY1A3(1), GUCY2C(2), GUCY2F(2), HTR2A(1), HTR2B(2), ITPR1(2), ITPR2(4), ITPR3(4), KRAS(1), MAP2K5(1), MAPK1(1), MAPK7(3), NRAS(1), PDGFA(1), PDGFC(1), PDGFD(1), PDGFRA(7), PLCB1(2), PLCB2(3), PLCB4(1), PRKACG(1), PRKCA(1), PRKCG(1), PRKG2(1), RAF1(1), SOS2(1), TJP1(3), TUBA3C(2), TUBA3D(1), TUBB3(1), TUBB6(1), TUBB8(1)	57044120	98	77	92	17	26	23	2	27	20	0	0.00359	0.953	1.000
385	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(2), ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH3B2(1), ALDH7A1(1), FBP2(1), G6PC(3), G6PC2(1), HK1(3), HK3(1), LDHA(1), LDHAL6B(1), LDHB(1), PDHA1(3), PDHA2(2), PDHB(1), PFKL(1), PGAM2(1), PGK1(1), PGM3(1), PKLR(1)	25089207	38	36	38	9	13	10	1	9	5	0	0.0740	0.954	1.000
386	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	FBP2(1), G6PD(2), PFKL(1), PGM3(1), PRPS1(1), PRPS1L1(1), PRPS2(1), TALDO1(1), TKTL2(1)	10480608	10	10	10	3	6	2	0	2	0	0	0.372	0.958	1.000
387	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(1), ICAM1(1), ITGAL(2), ITGB2(1), PTPRC(3)	4634569	8	7	8	4	5	1	0	1	1	0	0.667	0.958	1.000
388	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(1), ICAM1(1), ITGAL(2), ITGB2(1), PTPRC(3)	4860225	8	7	8	4	5	1	0	1	1	0	0.676	0.962	1.000
389	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(1), ACACA(4), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH6A1(1), ECHS1(1), HADHA(2), LDHA(1), LDHB(1)	14264471	19	18	19	5	7	5	0	4	3	0	0.311	0.962	1.000
390	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	ANKRD6(1), APC(1), CTNNB1(1), DKK2(2), LRP1(5), NKD2(1), SENP2(1), WIF1(2)	17407482	14	14	14	2	4	2	0	5	3	0	0.224	0.963	1.000
391	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	SREBF1(3)	5204811	3	2	3	0	0	2	0	1	0	0	0.351	0.966	1.000
392	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	F13B(1), HSD17B4(2), HSD3B2(1)	3487550	4	4	4	3	1	0	0	2	1	0	0.944	0.967	1.000
393	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), IFNAR1(2), MAPK8(1)	4779366	4	4	4	3	0	2	0	1	1	0	0.898	0.969	1.000
394	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX3(1), FADS2(1), FASN(1), HADHA(2), PECR(1)	6238209	6	6	6	4	0	2	0	2	2	0	0.895	0.971	1.000
395	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	GREB1(2)	4723804	2	2	2	0	2	0	0	0	0	0	0.416	0.972	1.000
396	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(3), AMY2B(1), ENPP1(1), ENPP3(2), G6PC(3), GANAB(2), HK1(3), HK3(1), MGAM(3), PGM3(1), PYGB(1), PYGL(1), SI(4), UGT1A1(3), UGT2B4(1), UXS1(2)	24520261	32	30	32	6	10	11	0	7	4	0	0.0668	0.972	1.000
397	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	FBP2(1), G6PD(2), PGM3(1), PRPS1(1), PRPS1L1(1), PRPS2(1), TALDO1(1)	8812474	8	8	8	3	5	2	0	1	0	0	0.490	0.972	1.000
398	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ASPH(2), LDHA(1), NOS3(3)	7331427	6	5	6	2	3	1	0	2	0	0	0.599	0.972	1.000
399	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	ABAT(1), ADSL(1), AGXT2(1), ASL(1), ASNS(1), CAD(2), CRAT(1), GAD2(1), PC(1)	11236344	10	9	10	2	5	2	0	1	2	0	0.359	0.972	1.000
400	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	MAPK1(1), RAF1(1)	3552238	2	2	2	2	0	1	0	0	1	0	0.864	0.972	1.000
401	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH3B2(1), FBP2(1), G6PC(3), HK1(3), HK3(1), LDHA(1), LDHB(1), PDHA1(3), PDHA2(2), PDHB(1), PGK1(1), PGM3(1), PKLR(1)	21059834	32	31	32	8	9	11	1	6	5	0	0.108	0.973	1.000
402	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH3B2(1), FBP2(1), G6PC(3), HK1(3), HK3(1), LDHA(1), LDHB(1), PDHA1(3), PDHA2(2), PDHB(1), PGK1(1), PGM3(1), PKLR(1)	21059834	32	31	32	8	9	11	1	6	5	0	0.108	0.973	1.000
403	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(2), APOA1(1), APOA4(1), LIPC(1), LPL(1), LRP1(5), SCARB1(1), SOAT1(1)	11796740	13	13	13	4	4	3	0	5	1	0	0.545	0.973	1.000
404	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(1), B3GNT3(1), B3GNT4(1), B3GNT5(2), FUT5(1), ST3GAL6(1)	6989115	7	7	7	3	0	3	0	2	2	0	0.725	0.974	1.000
405	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(1), CREBBP(4), CSNK2A1(1), CTNNB1(1), WIF1(2)	12657940	9	9	9	2	1	3	0	2	3	0	0.479	0.975	1.000
406	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT7(1), CHST1(1), FUT8(1), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1)	5385912	6	6	6	3	3	2	1	0	0	0	0.702	0.975	1.000
407	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	ETV5(1), IL12B(1), IL12RB1(1), IL18(2), JAK2(1), MAP2K6(1), MAPK8(1), TYK2(2)	8053825	10	10	10	6	2	2	1	2	3	0	0.909	0.976	1.000
408	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACTB(1), ACTG1(1), ACTN3(1), ACTN4(1), ACVR1C(1), CDH1(1), CREBBP(4), CSNK2A1(1), CTNNA2(1), CTNNA3(1), CTNNB1(1), EGFR(21), ERBB2(1), FARP2(1), IGF1R(2), IQGAP1(2), LMO7(1), MAPK1(1), MET(4), MLLT4(1), PTPRB(2), PTPRF(2), PTPRJ(2), PTPRM(2), PVRL3(1), RAC2(1), SMAD2(1), SMAD3(1), TCF7L2(2), TGFBR1(1), TGFBR2(1), TJP1(3), VCL(1), WAS(2), WASF3(2), YES1(1)	51612038	73	60	67	10	17	22	1	19	14	0	0.000786	0.976	1.000
409	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSD(1), ARSE(1), DEGS1(1), GALC(1), LCT(2), NEU1(1), NEU2(2), SMPD2(1), SMPD3(1), SMPD4(1)	15432647	12	12	12	2	5	2	0	3	2	0	0.280	0.976	1.000
410	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	YWHAH(1)	3328052	1	1	1	0	0	0	0	0	1	0	1.000	0.976	1.000
411	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	IL12B(1), IL12RB1(1), JAK2(1), TYK2(2)	6351991	5	5	5	4	1	0	1	1	2	0	0.949	0.977	1.000
412	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	GGT1(2), LTA4H(1), PTGS1(1), PTGS2(1)	6507513	5	5	5	2	2	1	0	1	1	0	0.674	0.977	1.000
413	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), AGK(1), AGPAT2(1), AGPAT3(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), DGKA(1), DGKD(2), DGKH(1), DGKQ(1), GK(1), GK2(3), GPAM(1), LCT(2), LIPC(1), LIPG(1), LPL(1), PNLIPRP1(2)	25285723	32	26	32	6	14	8	1	5	4	0	0.0355	0.977	1.000
414	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(1), GART(1), MTHFR(1)	7692807	3	3	3	1	1	0	0	1	1	0	0.671	0.979	1.000
415	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	RPL10L(1), RPL37A(1), RPL7(1), RPS2(1), RPS24(1)	9704954	5	5	5	1	2	0	0	2	1	0	0.724	0.980	1.000
416	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C3(6), C6(1), C7(2), C8A(2), MBL2(2)	9142828	13	13	13	6	5	3	0	1	4	0	0.719	0.980	1.000
417	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C3(6), C6(1), C7(2), C8A(2)	7513172	11	11	11	6	5	2	0	1	3	0	0.793	0.980	1.000
418	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(1), ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), SOAT2(1), SRD5A1(1)	10006782	15	15	15	5	6	3	0	3	3	0	0.428	0.980	1.000
419	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V1C2(1), ATP6V1D(1)	6479542	2	2	2	0	1	1	0	0	0	0	0.457	0.980	1.000
420	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V1C2(1), ATP6V1D(1)	6479542	2	2	2	0	1	1	0	0	0	0	0.457	0.980	1.000
421	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V1C2(1), ATP6V1D(1)	6479542	2	2	2	0	1	1	0	0	0	0	0.457	0.980	1.000
422	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(1), JAK2(1), JAK3(1), PIAS3(1), PTPRU(1), REG1A(1), SOAT1(1)	5912503	7	7	7	5	1	1	0	3	2	0	0.942	0.980	1.000
423	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ASL(1), CPS1(2), GLUD1(2)	7581686	5	4	5	3	0	0	0	2	3	0	0.967	0.981	1.000
424	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	F13A1(2), F2(3), FGA(1), FGB(1), FGG(1)	5768302	8	8	8	4	3	2	0	2	1	0	0.730	0.982	1.000
425	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(1), CREBBP(4), CTNNB1(1), LDB1(1), PITX2(1), TRRAP(4)	14301196	12	12	12	3	5	2	0	3	2	0	0.438	0.984	1.000
426	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	AGPAT2(1), AGPAT3(1), CHAT(1), DGKA(1), DGKD(2), DGKH(1), DGKQ(1), ESCO2(1), GNPAT(1), GPAM(1), LYPLA1(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PLD1(3)	28246196	22	20	22	2	8	6	1	3	4	0	0.0289	0.985	1.000
427	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	PRF1(1), SREBF1(3)	7906605	4	3	4	1	1	2	0	1	0	0	0.603	0.985	1.000
428	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ARPC1B(1), NCK1(1), NCKAP1(2), WASF3(2)	6568726	6	5	6	3	2	2	0	1	1	0	0.722	0.985	1.000
429	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V1C2(1), ATP6V1D(1)	6897071	2	2	2	0	1	1	0	0	0	0	0.458	0.987	1.000
430	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), AGPAT2(1), AGPAT3(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), DGKA(1), DGKD(2), DGKH(1), DGKQ(1), GK(1), LCT(2), LIPC(1), LIPG(1), LPL(1), PNLIPRP1(2)	20776832	27	23	27	6	12	6	1	4	4	0	0.0907	0.988	1.000
431	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT2(1), ACOT11(1), DHRS2(1), DHRSX(1), ECHS1(1), ESCO2(1), FN3K(1), HADHA(2)	11166274	9	8	9	3	2	2	0	2	3	0	0.672	0.989	1.000
432	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	FBP2(1), PGK1(1), PKLR(1)	7793275	3	3	3	1	2	1	0	0	0	0	0.599	0.990	1.000
433	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMC3(1)	5546589	1	1	1	0	0	1	0	0	0	0	0.677	0.990	1.000
434	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(1), CYCS(1), MAP3K1(2), MAPK1(1), MAPK8(1), RAF1(1), RIPK1(1), TRADD(1)	8865443	9	9	9	4	2	3	0	1	3	0	0.683	0.990	1.000
435	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BNIP1(1), STX11(1), TSNARE1(1), USE1(1), VAMP5(2)	7208649	6	6	5	3	3	1	0	0	2	0	0.706	0.991	1.000
436	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(6), C6(1), C7(2), ICAM1(1), IL6(1), ITGA4(1), ITGAL(2), ITGB2(1), SELP(1), SELPLG(1), TNF(1)	10658859	18	18	18	8	7	5	0	2	4	0	0.522	0.991	1.000
437	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	FOS(1), MAPK1(1), NFKBIA(1), PLCB1(2), PRKCA(1), RAF1(1), TNF(1)	6692104	8	8	8	4	1	3	0	2	2	0	0.692	0.991	1.000
438	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), TGFBR1(1), TGFBR2(1)	4546608	3	3	3	2	2	1	0	0	0	0	0.809	0.992	1.000
439	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	CP(1), EPRS(1), HCCS(2), PPOX(1), UGT1A1(3), UGT2B4(1)	11797588	9	9	9	3	0	4	0	5	0	0	0.666	0.992	1.000
440	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CREBBP(4), NFKBIA(1), RIPK1(1), TNF(1), TRADD(1)	9661334	8	8	8	3	2	2	0	1	3	0	0.708	0.993	1.000
441	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C3(6), C6(1), C7(2), C8A(2), C8B(1)	8931559	12	12	12	7	5	3	0	1	3	0	0.820	0.993	1.000
442	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	MAP3K1(2), NFKBIA(1), TNFAIP3(1)	7828857	4	4	4	2	2	1	0	0	1	0	0.719	0.994	1.000
443	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(1), ACAA2(1), ACADS(2), ACAT2(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH6A1(1), ALDH7A1(1), AOX1(2), DBT(1), ECHS1(1), HADHA(2), HSD17B4(2), MCCC1(1), MCCC2(2)	18519097	24	21	23	6	9	5	0	4	6	0	0.258	0.994	1.000
444	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	DAG1(1), ITPR1(2), ITPR2(4), ITPR3(4), NFAT5(2), PDE6B(3), PDE6C(3)	15443890	19	18	19	6	5	7	1	4	2	0	0.391	0.994	1.000
445	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVRL1(2), BUB1(1), CLK1(1), CLK4(1), CSNK2A1(1), DGKA(1), DGKD(2), DGKH(1), DGKQ(1), INPP4B(1), INPPL1(1), MAP3K10(1), OCRL(2), PAK4(1), PIK3C2B(1), PIK3CA(28), PIK3CG(2), PLCB1(2), PLCB2(3), PLCB4(1), PLCG1(4), PLCG2(4), PRKACG(1), PRKAR1A(2), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(1), RAF1(1), RPS6KA1(1), RPS6KA3(1), TGFBR1(1), VRK1(2)	48636298	75	63	62	14	14	28	3	16	14	0	0.0143	0.995	1.000
446	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	GLI3(1), PRKACG(1), PRKAR1A(2), SHH(1), SUFU(1)	7202261	6	6	6	4	1	2	0	1	2	0	0.919	0.995	1.000
447	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(4), MAPK1(1)	6384633	5	5	5	3	1	2	0	1	1	0	0.898	0.995	1.000
448	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	UGT1A1(3), UGT2B4(1)	7577691	4	4	4	2	0	1	0	3	0	0	0.842	0.996	1.000
449	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL22RA1(1), JAK2(1), JAK3(1), STAT3(1), STAT5B(1), TYK2(2)	7950800	7	7	7	5	2	0	0	3	2	0	0.961	0.996	1.000
450	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1)	5504515	1	1	1	0	0	1	0	0	0	0	0.673	0.996	1.000
451	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGTR2(1), F2(3), GNAI1(3), JAK2(1), MAPK1(1), MAPK8(1), MYLK(1), PLCG1(4), PRKCA(1), PTK2B(1), RAF1(1), SHC1(1), STAT3(1)	17953288	20	19	19	5	4	8	0	3	5	0	0.241	0.996	1.000
452	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	MAP3K1(2), NFKBIA(1), RIPK1(1), TANK(2), TNFAIP3(1)	9689912	7	7	7	3	3	2	0	0	2	0	0.667	0.996	1.000
453	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	DLG4(1), GRIN1(1), GRIN2A(3), GRIN2B(3), GRIN2C(2), GRIN2D(2), NOS1(1), PRKACG(1), PRKAR1A(2), PRKCA(1)	11039485	17	16	17	9	5	2	0	6	4	0	0.902	0.996	1.000
454	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(1), ABP1(3), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), CNDP1(1), DPYS(2), ECHS1(1), GAD2(1), HADHA(2)	12519589	18	17	18	7	8	3	0	2	5	0	0.546	0.996	1.000
455	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(2), HDAC2(3), NFATC1(1), NFATC2(2), PRKCA(1)	10507499	9	9	9	7	2	1	1	1	4	0	0.985	0.996	1.000
456	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(1), ALDH4A1(1), CAD(2), CPS1(2), EPRS(1), GAD2(1), GFPT1(1), GLUD1(2), GSS(1), NADSYN1(1)	14288654	13	13	13	4	3	4	0	3	3	0	0.621	0.996	1.000
457	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	BRAF(3), CACNA1A(2), GNAI1(3), GNAO1(3), GNAS(3), GRIA1(5), GRIA3(4), GRID2(1), GRM5(1), GUCY1A3(1), GUCY2C(2), GUCY2F(2), IGF1R(2), ITPR1(2), ITPR2(4), ITPR3(4), KRAS(1), MAPK1(1), NOS1(1), NOS3(3), NRAS(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(1), PLA2G4A(4), PLCB1(2), PLCB2(3), PLCB4(1), PPP2R2C(1), PRKCA(1), PRKCG(1), PRKG2(1), RAF1(1), RYR1(7)	47597813	74	61	74	14	18	22	3	18	13	0	0.0113	0.996	1.000
458	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(1), FUCA1(1), FUCA2(2), HEXA(1), LCT(2), MAN2B1(1), MAN2B2(1), MAN2C1(1), NEU1(1), NEU2(2)	8803573	13	13	13	6	4	2	1	3	3	0	0.787	0.997	1.000
459	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	IL4R(1), IRS1(2), JAK3(1), SHC1(1), STAT6(2)	6395596	7	7	7	4	2	1	0	3	1	0	0.830	0.997	1.000
460	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR7(1), CD28(1), CXCR4(1), IFNGR2(1), IL12B(1), IL12RB1(1), IL4R(1)	8618564	7	7	7	7	1	1	2	1	2	0	0.980	0.997	1.000
461	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	BMPR1B(1), CDKN1B(1), DMC1(1), ESR2(2), FSHR(1), MLH1(2), MSH5(1), NCOR1(3), ZP2(1)	15109417	13	13	13	4	2	4	0	3	4	0	0.692	0.997	1.000
462	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(1)	5765659	1	1	1	0	0	1	0	0	0	0	0.673	0.997	1.000
463	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMC3(1)	6887116	1	1	1	1	0	1	0	0	0	0	0.947	0.997	1.000
464	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(1), ACADS(2), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH6A1(1), AOX1(2), ECHS1(1), HADHA(2), MCCC1(1), MCCC2(2)	15504048	20	19	19	7	7	6	0	3	4	0	0.423	0.997	1.000
465	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(3), ADC(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), ASL(1), ASS1(1), CPS1(2)	12722162	15	15	15	9	8	1	0	1	5	0	0.916	0.998	1.000
466	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN3(1), CTNNA2(1), CTNNB1(1), VCL(1)	8298512	4	4	4	2	1	0	0	2	1	0	0.884	0.998	1.000
467	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	GTF2E1(1), NCOA1(1), NCOA2(1), NCOA3(1), NCOR2(3), POLR2A(1), RXRA(1)	10772473	9	9	9	6	3	3	0	0	3	0	0.919	0.998	1.000
468	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG5(1), FUT8(1), MGAT2(1), MGAT3(2), MGAT5(1)	8605344	6	6	6	3	2	2	0	1	1	0	0.786	0.998	1.000
469	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(1), COL4A4(1), COL4A5(3), COL4A6(3), SLC23A1(1), SLC23A2(1), SLC2A3(1)	10797020	11	11	11	5	5	4	1	1	0	0	0.512	0.998	1.000
470	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	IL12B(1), ITGAX(1), TLR2(1), TLR7(2), TLR9(2)	8005526	7	6	7	4	2	0	1	3	1	0	0.916	0.998	1.000
471	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	PLCB1(2), PRKACG(1), PRKAR1A(2)	6918479	5	5	5	3	1	0	0	3	1	0	0.962	0.998	1.000
472	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(3), ALDH1A3(1), ALDH3A1(3), ALDH3B2(1), DDC(1), LPO(3), MPO(2), TAT(1), TPO(3)	9486911	18	17	18	7	10	3	2	1	2	0	0.486	0.998	1.000
473	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CFL1(1), GNAS(3), LIMK1(3), MAPK1(1), PLCB1(2), PRKCA(1), RAF1(1), ROCK2(1)	10807756	13	13	13	5	2	3	0	5	3	0	0.740	0.998	1.000
474	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(3), GNAI1(3), MAPK1(1), PLA2G4A(4), PLCB1(2), PRKCA(1), PTGS1(1), RAF1(1)	10509208	16	16	16	6	1	5	0	7	3	0	0.660	0.999	1.000
475	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	FBP2(1), PGK1(1), PKLR(1), TKTL2(1)	8709804	4	4	4	2	2	1	0	1	0	0	0.736	0.999	1.000
476	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F13B(1), F2(3), F5(4), F7(1), F8(3), FGA(1), FGB(1), FGG(1), LPA(1), VWF(3)	15204486	19	17	19	7	6	5	1	3	4	0	0.458	0.999	1.000
477	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA2(1), ACAD8(1), ACAD9(1), ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), HSD3B7(1), SOAT1(1), SOAT2(1), SRD5A1(1)	13626237	19	18	19	7	7	2	0	7	3	0	0.593	0.999	1.000
478	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	ABP1(3), ESCO2(1)	10903635	4	4	4	2	2	1	0	0	1	0	0.809	0.999	1.000
479	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CLOCK(1), PER1(2), PER2(1)	7356377	4	4	4	3	0	2	0	1	1	0	0.929	0.999	1.000
480	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	FPR1(1), MAP2K3(1), MAP2K6(1), MAP3K1(2), MAPK1(1), NCF2(1), NFATC1(1), NFATC2(2), NFATC4(1), NFKBIA(1), PAK1(1), PLCB1(2), RAF1(1)	16501654	16	15	16	5	5	2	0	3	6	0	0.427	0.999	1.000
481	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	FOS(1), MAP3K1(2), MAPK8(1), NFATC1(1), NFATC2(2), NFATC4(1), PLCG1(4), PRKCA(1), RAF1(1), SHC1(1), VAV1(3)	16478915	18	17	17	6	6	6	0	3	3	0	0.436	0.999	1.000
482	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	CYCS(1), GAS2(1), LMNA(1), NFKBIA(1), RIPK1(1), SPTAN1(2), TRADD(1)	14415675	8	6	8	2	3	1	0	1	3	0	0.467	0.999	1.000
483	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	HDAC5(1), YWHAH(1)	8738915	2	2	2	1	1	0	0	0	1	0	0.888	0.999	1.000
484	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(1), ADRBK2(1), ARRB2(1), CALML3(1), CLCA1(1), CLCA2(1), CNGA3(1), CNGB1(1), GUCA1A(1), PDE1C(1), PRKACG(1), PRKG2(1)	13145628	12	11	12	7	4	1	0	3	4	0	0.867	0.999	1.000
485	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	DNMT1(1), DNMT3A(4), DNMT3B(1), MARS2(1), TAT(1)	8945719	8	8	8	4	2	2	1	2	1	0	0.721	0.999	1.000
486	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	ARHGDIB(1), CASP1(1), CYCS(1), LMNA(1), LMNB2(1), PRF1(1)	8320667	6	5	6	3	2	2	0	2	0	0	0.815	0.999	1.000
487	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(1), AGTR2(1), CMA1(1), COL4A1(1), COL4A4(1), COL4A5(3), COL4A6(3), REN(1)	10866940	12	12	12	6	6	4	0	1	1	0	0.658	0.999	1.000
488	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	CES2(1), CYP3A4(2), UGT1A1(3)	9830157	6	6	6	3	1	1	0	3	1	0	0.856	1.000	1.000
489	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	IL1R1(1), MAP3K1(2), NFKBIA(1), RIPK1(1), TNF(1), TNFAIP3(1), TRADD(1)	10528674	8	8	8	5	3	3	0	0	2	0	0.863	1.000	1.000
490	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	150	CBLB(1), CBLC(1), CISH(1), CNTFR(1), CREBBP(4), CRLF2(2), CSF2RA(3), CSF2RB(1), GH1(1), GHR(1), IFNA21(1), IFNA5(1), IFNAR1(2), IFNGR2(1), IL12B(1), IL12RB1(1), IL13RA1(1), IL15(1), IL19(1), IL20RA(1), IL22RA1(1), IL23R(1), IL2RB(2), IL4R(1), IL6(1), IL6ST(2), IL7R(1), IL9R(2), JAK2(1), JAK3(1), LIFR(1), OSMR(1), PIAS3(1), PIK3CA(28), PIK3CG(2), PIK3R1(14), PIK3R5(1), PIM1(1), PTPN11(5), SOCS5(1), SOS2(1), SPRED2(1), SPRY2(1), SPRY4(1), STAT3(1), STAT5B(1), STAT6(2), TPO(3), TYK2(2)	62568826	108	88	93	26	13	33	5	30	27	0	0.0908	1.000	1.000
491	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	FBP2(1), GMDS(1), HK1(3), HK3(1)	10334603	6	6	6	3	2	3	0	0	1	0	0.675	1.000	1.000
492	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(1), ATF2(1), BMP4(2), CTNNB1(1), GATA4(1), RFC1(1), TGFBR1(1), TGFBR2(1)	15690578	9	9	9	3	3	2	0	1	3	0	0.720	1.000	1.000
493	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(1), FUCA1(1), FUCA2(2), HEXA(1), HYAL1(1), IDS(1), LCT(2), MAN2B1(1), MAN2B2(1), MAN2C1(1), NAGLU(2), NEU1(1), NEU2(2), SPAM1(1)	14915874	18	18	18	6	5	4	1	4	4	0	0.541	1.000	1.000
494	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(3), ALDH1A3(1), ALDH3A1(3), ALDH3B2(1), DDC(1), ESCO2(1), LPO(3), MPO(2), TAT(1), TPO(3)	14741023	19	18	19	7	10	3	2	1	3	0	0.499	1.000	1.000
495	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ACTB(1), ACTG1(1), ARHGEF2(2), CDH1(1), CTNNB1(1), CTTN(1), HCLS1(1), NCK1(1), NCL(1), PRKCA(1), ROCK2(1), TLR5(1), TUBA3C(2), TUBA3D(1), TUBB3(1), TUBB6(1), TUBB8(1), WAS(2)	22595341	21	21	21	6	8	2	3	3	5	0	0.413	1.000	1.000
496	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ACTB(1), ACTG1(1), ARHGEF2(2), CDH1(1), CTNNB1(1), CTTN(1), HCLS1(1), NCK1(1), NCL(1), PRKCA(1), ROCK2(1), TLR5(1), TUBA3C(2), TUBA3D(1), TUBB3(1), TUBB6(1), TUBB8(1), WAS(2)	22595341	21	21	21	6	8	2	3	3	5	0	0.413	1.000	1.000
497	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ALG6(1), CELSR1(5), CELSR2(1), CELSR3(5), CHRM3(3), EMR2(1), EMR3(1), FSHR(1), GNRHR(1), GPR116(4), GPR132(1), GPR133(1), GPR17(1), GRPR(3), HRH4(1), LPHN2(2), LPHN3(3), OR8G2(2), SSTR2(1), TAAR5(1), TSHR(2)	28768948	41	40	41	11	12	14	2	9	4	0	0.111	1.000	1.000
498	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	ABAT(1), ADSL(1), ADSSL1(1), AGXT2(1), ASL(1), ASNS(1), ASS1(1), CAD(2), CRAT(1), DARS2(1), GAD2(1), PC(1), PDHA1(3), PDHA2(2), PDHB(1)	16316557	19	17	19	5	7	6	0	3	3	0	0.329	1.000	1.000
499	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	UGT1A1(3), UGT2A3(1), UGT2B10(4), UGT2B11(3), UGT2B28(2), UGT2B4(1), UGT2B7(1)	11758667	15	14	15	6	2	3	0	10	0	0	0.762	1.000	1.000
500	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN3(1), ACTN4(1), CDH5(1), CLDN11(1), CLDN14(1), CLDN16(1), CLDN19(1), CTNNA2(1), CTNNA3(1), CTNNB1(1), CXCR4(1), CYBB(1), ESAM(1), GNAI1(3), ICAM1(1), ITGA4(1), ITGAL(2), ITGB2(1), JAM2(1), MAPK12(1), MLLT4(1), MMP9(1), NCF2(1), PIK3CA(28), PIK3CG(2), PIK3R1(14), PIK3R5(1), PLCG1(4), PLCG2(4), PRKCA(1), PRKCG(1), PTK2B(1), PTPN11(5), RAC2(1), RHOH(1), ROCK2(1), SIPA1(1), VAV1(3), VAV3(8), VCL(1)	53623857	103	80	80	24	22	28	4	19	30	0	0.0722	1.000	1.000
501	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(1), POLR2A(1), POLR2B(1), POLR2G(1), POLR3A(3), POLR3B(1), POLR3GL(1), POLR3K(1)	10106462	10	10	10	6	2	4	1	2	1	0	0.875	1.000	1.000
502	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(2), POLD1(1), POLE(1), POLQ(2), PRIM1(1), PRIM2(2), REV1(3), REV3L(1)	17383018	13	11	13	7	5	2	0	2	4	0	0.958	1.000	1.000
503	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(1), NFKBIA(1), RIPK1(1), TNF(1), TNFAIP3(1), TRADD(1)	11749550	6	6	6	5	2	1	0	1	2	0	0.960	1.000	1.000
504	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	EPRS(1), FARS2(2), GARS(1), HARS(1), LARS(1), MARS2(1), RARS(1), WARS2(1)	13780686	9	9	9	4	1	6	0	2	0	0	0.707	1.000	1.000
505	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	G6PC(3), G6PC2(1), GANC(1), HK1(3), HK3(1), HSD3B7(1), LCT(2), MGAM(3), PFKL(1), PGM3(1)	16696536	17	16	17	6	8	5	0	3	1	0	0.388	1.000	1.000
506	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(2), CALCR(1), CD97(1), ELTD1(1), EMR1(1), EMR2(1), GIPR(1), GLP2R(1), GPR64(2), LPHN2(2), LPHN3(3), SCTR(1)	11524661	17	15	17	8	3	6	1	6	1	0	0.796	1.000	1.000
507	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(1), FOS(1), IL2RB(2), JAK3(1), MAPK8(1), RAF1(1), SHC1(1), STAT5B(1)	10086593	9	9	9	5	0	4	0	4	1	0	0.817	1.000	1.000
508	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	PIGB(1), PIGS(1), PIGW(1), PIGZ(1)	10254746	4	4	4	3	1	0	0	2	1	0	0.943	1.000	1.000
509	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(3), CASP1(1), MAGI2(2), RERE(4)	10330481	10	10	10	5	3	2	0	4	1	0	0.880	1.000	1.000
510	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(1), ADC(1), ALDH4A1(1), CAD(2), CPS1(2), EPRS(1), GAD2(1), GFPT1(1), GFPT2(2), GLUD1(2), GLUD2(1), GSS(1), NADSYN1(1)	17016905	17	16	17	6	3	5	0	5	4	0	0.722	1.000	1.000
511	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(1), ARHGDIB(1), BAG4(1), CRADD(1), CYCS(1), LMNA(1), LMNB2(1), MAP3K1(2), MAP3K5(2), MAPK8(1), MDM2(2), NFKBIA(1), NUMA1(3), PRKDC(3), RASA1(2), RB1(3), RIPK1(1), SPTAN1(2), TNF(1), TRADD(1)	29726062	31	27	31	7	7	9	1	7	7	0	0.197	1.000	1.000
512	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AP2M1(1), EEA1(1), PFKL(1), PLCG1(4)	10751892	7	7	6	4	2	3	0	1	1	0	0.852	1.000	1.000
513	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	CREBBP(4), GTF2E1(1), HDAC2(3), HDAC4(2), HDAC5(1), HDAC6(2), NCOR2(3), POLR2A(1)	19982093	17	17	17	8	7	2	0	2	6	0	0.902	1.000	1.000
514	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG13(1), ALG14(1), ALG5(1), ALG6(1), DAD1(1), DHDDS(1), FUT8(1), GANAB(2), MAN2A1(1), MGAT2(1), MGAT3(2), MGAT5(1), MGAT5B(1), STT3B(2)	18273572	17	16	17	5	3	4	1	5	4	0	0.602	1.000	1.000
515	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	CLOCK(1), ETV6(2), HSPA8(2), IDI1(1), NCKAP1(2), NCOA4(2), PER1(2), PER2(1), SF3A3(1), TUBB3(1)	15750114	15	15	15	6	3	4	0	5	3	0	0.764	1.000	1.000
516	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	FBP2(1), G6PC(3), GANAB(2), HK1(3), HK3(1), LCT(2), MGAM(3), PGM3(1)	14071914	16	15	16	6	8	4	0	3	1	0	0.462	1.000	1.000
517	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	CTCFL(1), DOT1L(1), EHMT1(1), EHMT2(1), EZH1(1), FBXO11(1), HCFC1(2), JMJD6(1), KDM6A(1), MEN1(1), MLL(4), MLL2(9), MLL3(5), MLL5(2), OGT(5), PPP1CB(1), PRDM2(2), PRDM9(4), PRMT5(2), PRMT8(1), SATB1(1), SETD2(4), SETD8(1), SETMAR(2), STK38(1), SUV39H1(1), SUV420H1(1), SUZ12(1)	51182218	58	51	58	11	10	14	2	16	16	0	0.0753	1.000	1.000
518	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(1), ANGPTL2(1), CFL1(1), FLNA(3), FLNC(4), FSCN3(2), GDI1(2), LIMK1(3), MYH2(9), MYLK(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), ROCK2(1), RPS4X(1)	20660650	33	28	33	10	13	9	1	8	2	0	0.230	1.000	1.000
519	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTN3(1), SPTAN1(2), TLN1(3)	12318025	6	6	6	4	2	0	0	3	1	0	0.922	1.000	1.000
520	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(2), ATP4A(3), ATP6V0A2(1), ATP6V1C2(1), ATP6V1D(1), COX7B(1), NDUFA3(1), NDUFS1(1), NDUFS3(1), NDUFV2(1), SDHA(3), SDHC(1), TCIRG1(1), UQCRC1(1), UQCRH(1)	24042366	20	17	19	6	7	5	0	3	5	0	0.573	1.000	1.000
521	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(3), ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A3(1), ALDH3A1(3), ALDH3B2(1), AOX1(2), DBH(1), DDC(1), HGD(2), TAT(1), TH(1), TPO(3), TYR(2)	13673039	26	25	26	10	9	5	2	6	4	0	0.503	1.000	1.000
522	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDHPPT(1), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), DOT1L(1), ECHS1(1), EHMT1(1), EHMT2(1), HADHA(2), PLOD1(1)	15982905	16	14	16	8	5	3	0	3	5	0	0.706	1.000	1.000
523	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(1), ACADS(2), ACADVL(1), ACAT2(1), ACOX3(1), ACSL1(3), ACSL4(1), ACSL6(1), ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), CYP4A11(1), CYP4A22(1), ECHS1(1), HADHA(2), HSD17B4(2)	21087760	30	28	30	10	8	5	0	7	10	0	0.492	1.000	1.000
524	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	BAX(1), CASP1(1), CRADD(1), CYCS(1), FASLG(1), IKBKE(2), NFKBIA(1), NR3C1(1), RIPK1(1), TNF(1), TRADD(1)	18716575	12	12	12	8	4	2	0	3	3	0	0.941	1.000	1.000
525	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDT1(1), DIAPH2(1), MCM10(1), MCM6(1), MCM7(1), POLD1(1), POLE(1), PRIM1(1), RFC1(1), RPA1(1), UBC(2)	21782990	12	9	12	7	3	2	0	2	5	0	0.947	1.000	1.000
526	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(2), CANT1(3), CTPS2(1), DCTD(1), DHODH(1), DPYS(2), NT5C(2), NT5E(1), POLD1(1), POLE(1), POLQ(2), POLR2A(1), POLR2B(1), POLR2G(1), RRM1(1), TK2(1), UCK1(1), UMPS(1)	24720875	24	23	24	9	7	7	2	2	6	0	0.662	1.000	1.000
527	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	GTF2E1(1), GTF2H4(1), POLR1A(1), POLR2A(1), POLR2B(1), POLR2G(1), POLR3B(1), POLR3D(1), POLR3K(1), TAF6(1)	15095612	10	10	10	9	3	4	1	1	1	0	0.974	1.000	1.000
528	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR2(1), ATP8A1(1), AVPR1A(2), BRS3(1), CCR10(1), CCR7(1), CXCR4(1), FPR1(1), FSHR(1), GALR1(1), GNRHR(1), GRPR(3), MC3R(1), MC4R(1), MC5R(1), NMBR(2), NPY1R(1), NPY2R(1), OPRD1(1), PPYR1(1), SSTR2(1), SSTR3(2), SSTR4(5), TACR2(2), TACR3(1), TSHR(2)	22591653	37	33	37	13	14	11	1	9	2	0	0.287	1.000	1.000
529	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	82	CD1B(2), CD1E(2), CD22(2), CD36(1), CD44(2), CR1(3), CR2(2), CSF2RA(3), DNTT(1), FCGR1A(1), HLA-DRA(1), HLA-DRB5(2), IL1R1(1), IL1R2(1), IL4R(1), IL6(1), IL7R(1), IL9R(2), ITGA2(1), ITGA2B(1), ITGA4(1), ITGA5(1), KIT(2), MS4A1(1), TFRC(2), TNF(1), TPO(3)	35076777	42	37	42	12	11	15	1	11	4	0	0.147	1.000	1.000
530	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(2), C3(6), C4BPA(1), C4BPB(1), C6(1), C7(2), C8A(2), C8B(1), CD46(1), CFH(4), CR1(3), CR2(2), F13A1(2), F13B(1), F2(3), F5(4), F7(1), F8(3), FGA(1), FGB(1), FGG(1), KLKB1(3), MBL2(2), PROS1(1), SERPING1(2), VWF(3)	38953548	54	48	54	15	19	15	1	8	11	0	0.127	1.000	1.000
531	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), AKR1C3(2), ALDH1A3(1), ALDH3A1(3), ALDH3B2(1), CYP1A2(2), CYP2B6(1), CYP2C19(5), CYP2C8(1), CYP2S1(1), CYP3A4(2), CYP3A7(1), EPHX1(1), UGT1A1(3), UGT2A3(1), UGT2B10(4), UGT2B11(3), UGT2B28(2), UGT2B4(1), UGT2B7(1)	24695216	41	34	41	13	15	5	1	14	6	0	0.419	1.000	1.000
532	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(1), CAD(2), CANT1(3), CTPS2(1), DCTD(1), DHODH(1), DPYS(2), ENTPD5(1), ENTPD6(1), NT5C(2), NT5E(1), POLA1(2), POLD1(1), POLE(1), POLR1A(1), POLR2A(1), POLR2B(1), POLR2G(1), POLR3A(3), POLR3B(1), POLR3GL(1), POLR3K(1), PRIM1(1), PRIM2(2), RRM1(1), TK2(1), TXNRD2(1), UCK1(1), UMPS(1), UPRT(1)	34838967	39	38	39	10	6	11	4	7	11	0	0.308	1.000	1.000
533	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	ABO(1), B3GNT3(1), B3GNT4(1), B3GNT5(2), B4GALNT1(1), FUT5(1), PIGB(1), PIGS(1), PIGZ(1), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1), ST3GAL6(1), ST6GALNAC3(1), ST8SIA5(1)	20939560	16	16	16	7	4	3	1	5	3	0	0.775	1.000	1.000
534	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(1), BRAF(3), FOS(1), MAP2K3(1), MAP2K5(1), MAP2K6(1), MAP3K1(2), MAP3K10(1), MAP3K12(2), MAP3K13(1), MAP3K4(2), MAP3K5(2), MAP4K4(1), MAPK1(1), MAPK12(1), MAPK4(1), MAPK7(3), MAPK8(1), MAPK9(1), MAPKAPK5(2), MAX(3), MKNK1(1), NFKBIA(1), PAK1(1), RAF1(1), RIPK1(1), RPS6KA1(1), RPS6KA3(1), SHC1(1), TGFBR1(1), TRADD(1)	41061360	42	38	41	10	7	14	0	10	11	0	0.208	1.000	1.000
535	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(4), ACACB(5), BRAF(3), CALML3(1), CBLB(1), CBLC(1), FASN(1), FBP2(1), FLOT1(1), FLOT2(2), G6PC(3), G6PC2(1), IRS1(2), IRS4(2), KRAS(1), LIPE(1), MAPK1(1), MAPK8(1), MAPK9(1), MKNK1(1), NRAS(1), PCK1(1), PDE3A(1), PFKL(1), PHKA2(2), PHKB(1), PIK3CA(28), PIK3CG(2), PIK3R1(14), PIK3R5(1), PKLR(1), PPARGC1A(1), PPP1CB(1), PPP1R3A(1), PRKAA1(1), PRKACG(1), PRKAR1A(2), PTPRF(2), PYGB(1), PYGL(1), RAF1(1), RAPGEF1(2), SHC1(1), SOS2(1), SREBF1(3), TSC1(1), TSC2(2)	69320633	109	88	95	25	24	38	3	23	21	0	0.0232	1.000	1.000
536	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP6(1), ARPC1B(1), CFL1(1), DIAPH1(2), LIMK1(3), MYLK(1), OPHN1(2), TLN1(3), VCL(1)	19549533	15	15	15	6	4	3	0	6	2	0	0.709	1.000	1.000
537	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(3), ADH1A(1), ADH1B(2), ADH1C(1), ADH7(1), ALDH1A3(1), ALDH3A1(3), ALDH3B2(1), AOX1(2), DBH(1), DDC(1), ESCO2(1), HGD(2), PRMT5(2), PRMT8(1), TAT(1), TH(1), TPO(3), TYR(2), TYRP1(2)	25611800	32	29	32	10	9	8	3	6	6	0	0.345	1.000	1.000
538	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	FBP2(1), GMDS(1), HK1(3), HK3(1), HSD3B7(1), MTMR6(1), PFKL(1), TSTA3(1)	16074771	10	10	10	5	3	5	0	1	1	0	0.675	1.000	1.000
539	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	AR(1), ESR2(2), NR1H3(1), NR3C1(1), NR4A1(1), NR5A2(1), PPARG(1), RXRA(1), RXRG(3), THRA(1)	18191302	13	11	13	8	4	3	1	3	2	0	0.948	1.000	1.000
540	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	DLG4(1), LPA(1), MAP3K1(2), MAP3K5(2), MAPK8(1), NFKBIA(1), PDK1(2), PHKA2(2), PI3(1), PLD1(3), RDX(1), ROCK2(1), SRF(1)	21109372	19	19	19	7	3	4	2	8	2	0	0.749	1.000	1.000
541	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(1), CTNNB1(1), DVL2(1), FZD10(1), FZD5(1), FZD6(1), FZD7(1), FZD9(1), MAPK9(1), PAFAH1B1(2), PPP2R5E(1), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(1), WNT11(2), WNT16(1), WNT2(1), WNT7A(1)	25956401	21	20	21	8	10	2	0	4	5	0	0.617	1.000	1.000
542	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(1), BRAF(3), CALML3(1), CREBBP(4), GRIA1(5), GRIN1(1), GRIN2A(3), GRIN2B(3), GRIN2C(2), GRIN2D(2), GRM5(1), ITPR1(2), ITPR2(4), ITPR3(4), KRAS(1), MAPK1(1), NRAS(1), PLCB1(2), PLCB2(3), PLCB4(1), PPP1CB(1), PPP3R2(1), PRKACG(1), PRKCA(1), PRKCG(1), RAF1(1), RPS6KA1(1), RPS6KA3(1), RPS6KA6(1)	42943445	54	52	54	16	14	12	3	18	7	0	0.329	1.000	1.000
543	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASDHPPT(1), ACAT2(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), DOT1L(1), ECHS1(1), EHMT1(1), EHMT2(1), HADHA(2), HSD17B4(2), HSD3B7(1), OGDHL(1), PLOD1(1), SUV39H1(1)	25064303	21	19	21	8	7	2	0	6	6	0	0.612	1.000	1.000
544	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	131	ACTB(1), ACTG1(1), ACTN3(1), ACTN4(1), AMOTL1(3), CASK(1), CLDN11(1), CLDN14(1), CLDN16(1), CLDN19(1), CSNK2A1(1), CTNNA2(1), CTNNA3(1), CTNNB1(1), CTTN(1), EPB41L1(1), EPB41L2(2), EPB41L3(2), EXOC4(2), GNAI1(3), HCLS1(1), INADL(1), JAM2(1), KRAS(1), LLGL2(1), MAGI2(2), MAGI3(1), MLLT4(1), MPDZ(3), MYH1(2), MYH10(2), MYH11(4), MYH13(5), MYH14(2), MYH15(5), MYH2(9), MYH3(3), MYH4(8), MYH6(2), MYH7(1), MYH7B(3), MYH8(6), NRAS(1), PPM1J(1), PPP2R2C(1), PPP2R3A(1), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(1), PTEN(13), RAB3B(1), RRAS(1), SPTAN1(2), TJP1(3), YES1(1)	83540076	120	93	120	26	42	25	2	28	23	0	0.0135	1.000	1.000
545	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADCY9(2), CALML3(1), CREB3(3), CREBBP(4), CTNNB1(1), DVL2(1), FZD10(1), FZD5(1), FZD6(1), FZD7(1), FZD9(1), GNAI1(3), GNAO1(3), GNAS(3), KIT(2), KRAS(1), MAPK1(1), NRAS(1), PLCB1(2), PLCB2(3), PLCB4(1), PRKACG(1), PRKCA(1), PRKCG(1), RAF1(1), TCF7L2(2), TYR(2), TYRP1(2), WNT11(2), WNT16(1), WNT2(1), WNT7A(1), WNT8A(1), WNT9B(1)	47099701	62	54	62	16	24	7	0	15	16	0	0.220	1.000	1.000
546	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(1), IL6ST(2), RPL23(1), RPL7(1), RPL7A(1), RPS2(1), RPS24(1), RPS4X(1), RPS6KA1(1), RPS6KA3(1), RPS6KA6(1), SLC36A2(1), UBC(2)	22538352	15	15	15	6	0	4	1	8	2	0	0.832	1.000	1.000
547	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	ABP1(3), ACAT2(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH7A1(1), AOX1(2), CYP1A2(2), DDC(1), ECHS1(1), HADHA(2), HSD17B4(2), LNX1(1), NFX1(1), OGDHL(1), PRMT5(2), PRMT8(1), TDO2(1), WARS2(1)	26107442	29	28	29	10	11	9	1	4	4	0	0.380	1.000	1.000
548	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTN3(1), BCR(1), MAPK1(1), MAPK8(1), RAF1(1), SHC1(1), TLN1(3), VCL(1)	20351425	10	10	10	6	1	3	0	5	1	0	0.914	1.000	1.000
549	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	ALG13(1), ALG14(1), ALG6(1), B3GNT7(1), C1GALT1(1), CHPF(1), CHST1(1), CHST11(1), CHST13(1), CHSY1(1), DAD1(1), EXT1(1), EXT2(1), EXTL1(2), FUT8(1), GALNT1(1), GALNT14(1), GALNT4(1), GALNT5(1), GALNT6(1), GALNTL1(1), GALNTL4(1), GALNTL5(1), GANAB(2), HS3ST3A1(1), HS6ST2(2), MAN2A1(1), MGAT2(1), MGAT3(2), MGAT5(1), MGAT5B(1), NDST2(1), NDST3(2), OGT(5), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1), ST6GALNAC1(1), STT3B(2), WBSCR17(4), XYLT1(2)	47592682	55	48	55	14	17	12	3	14	9	0	0.205	1.000	1.000
550	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	DARS2(1), EPRS(1), FARS2(2), GARS(1), HARS(1), IARS2(1), LARS(1), MARS2(1), RARS(1), RARS2(2), WARS2(1)	23363114	13	12	13	8	1	7	0	4	1	0	0.932	1.000	1.000
551	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1C(1), ACVR2A(2), ACVRL1(2), BMP4(2), BMPR1B(1), CREBBP(4), CUL1(1), DCN(1), GDF6(1), LEFTY2(1), LTBP1(1), MAPK1(1), PITX2(1), PPP2R2C(1), ROCK2(1), SMAD1(1), SMAD2(1), SMAD3(1), SMAD5(1), SMAD6(1), SMAD9(1), SMURF2(1), TGFBR1(1), TGFBR2(1), THBS1(1), THBS2(1), THBS4(1), TNF(1)	42787774	34	31	34	10	11	10	2	6	5	0	0.253	1.000	1.000
552	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADCY9(2), ADRA1B(1), ADRB2(1), ANXA6(1), ARRB2(1), ATP2B2(1), ATP2B3(3), CACNA1A(2), CACNA1B(4), CACNA1D(1), CACNA1E(6), CACNA1S(5), CACNB3(1), CALR(1), CASQ2(1), CHRM1(1), CHRM3(3), CHRM5(1), GJA1(1), GJB2(1), GJB6(1), GNAO1(3), GNB2(1), GNG12(1), GRK4(1), ITPR1(2), ITPR2(4), ITPR3(4), KCNB1(3), MYCBP(1), PEA15(1), PRKAR1A(2), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(1), RGS19(1), RGS3(4), RGS6(1), RGS9(1), RYR1(7), RYR2(10), RYR3(3), SLC8A3(2), YWHAH(1)	80909542	104	75	103	28	34	23	4	24	19	0	0.106	1.000	1.000
553	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(3), AMY2B(1), DDX4(2), DDX51(2), DDX52(1), DDX55(1), DDX56(1), ENPP1(1), ENPP3(2), G6PC(3), G6PC2(1), GANC(1), HK1(3), HK3(1), IFIH1(2), MGAM(3), MOV10L1(1), PGM3(1), PYGB(1), PYGL(1), RAD54L(1), RUVBL2(1), SETX(3), SI(4), SKIV2L2(1), UGT1A1(3), UGT2A3(1), UGT2B10(4), UGT2B11(3), UGT2B28(2), UGT2B4(1), UGT2B7(1), UXS1(2)	53282909	59	52	59	17	17	18	0	17	7	0	0.231	1.000	1.000
554	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(1), ACTG1(1), ACTN3(1), ACTN4(1), BRAF(3), COL11A1(1), COL1A2(5), COL2A1(1), COL3A1(3), COL4A1(1), COL4A4(1), COL4A6(3), COL5A1(1), COL5A2(1), COL6A3(6), COL6A6(1), CTNNB1(1), DIAPH1(2), DOCK1(1), EGF(3), EGFR(21), ERBB2(1), FARP2(1), FLNA(3), FLNB(4), FLNC(4), HGF(2), IBSP(1), IGF1R(2), ITGA10(1), ITGA11(2), ITGA2(1), ITGA2B(1), ITGA4(1), ITGA5(1), ITGA8(1), ITGB6(1), ITGB7(1), ITGB8(1), KDR(4), LAMA1(3), LAMA2(3), LAMA3(8), LAMA4(1), LAMA5(5), LAMB1(1), LAMB4(3), LAMC1(1), LAMC2(1), LAMC3(2), MAPK1(1), MAPK8(1), MAPK9(1), MET(4), MYLK(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PARVB(1), PDGFA(1), PDGFC(1), PDGFD(1), PDGFRA(7), PGF(1), PIK3CA(28), PIK3CG(2), PIK3R1(14), PIK3R5(1), PPP1CB(1), PRKCA(1), PRKCG(1), PTEN(13), RAC2(1), RAF1(1), RAPGEF1(2), RELN(4), ROCK2(1), SHC1(1), SOS2(1), SPP1(1), THBS1(1), THBS2(1), THBS4(1), TLN1(3), TLN2(1), TNC(2), TNN(2), TNR(1), TNXB(4), VAV1(3), VAV3(8), VCL(1), VEGFB(2), VEGFC(2), VWF(3)	160129234	252	151	224	61	58	75	7	59	53	0	0.00286	1.000	1.000
555	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ACTN3(1), ACTN4(1), APC(1), ARHGEF12(1), ARHGEF4(2), ARHGEF6(2), ARPC1B(1), BRAF(3), CFL1(1), CHRM1(1), CHRM3(3), CHRM5(1), CYFIP2(1), DIAPH1(2), DIAPH2(1), DIAPH3(1), DOCK1(1), EGF(3), EGFR(21), F2(3), FGF4(1), FGF5(2), FGF6(1), FGF7(1), FGFR2(1), FGFR4(1), GNG12(1), IQGAP1(2), ITGA10(1), ITGA11(2), ITGA2(1), ITGA2B(1), ITGA4(1), ITGA5(1), ITGA8(1), ITGAD(1), ITGAE(1), ITGAL(2), ITGAX(1), ITGB2(1), ITGB6(1), ITGB7(1), ITGB8(1), KRAS(1), LIMK1(3), MAPK1(1), MYH10(2), MYH14(2), MYLK(1), NCKAP1(2), NCKAP1L(2), NRAS(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PDGFA(1), PDGFRA(7), PFN4(1), PIK3CA(28), PIK3CG(2), PIK3R1(14), PIK3R5(1), PIP4K2B(1), PIP4K2C(2), PPP1CB(1), RAC2(1), RAF1(1), RDX(1), ROCK2(1), RRAS(1), SCIN(1), SOS2(1), SSH1(1), TIAM1(2), TIAM2(2), VAV1(3), VAV3(8), VCL(1), WAS(2)	119270812	181	132	154	45	26	52	6	49	48	0	0.0642	1.000	1.000
556	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY7(1), ADCY9(2), ADRA1B(1), ADRB2(1), ATP2B2(1), ATP2B3(3), AVPR1A(2), CACNA1A(2), CACNA1B(4), CACNA1D(1), CACNA1E(6), CACNA1F(3), CACNA1G(1), CACNA1H(2), CACNA1I(1), CACNA1S(5), CALML3(1), CHRM1(1), CHRM3(3), CHRM5(1), EGFR(21), ERBB2(1), ERBB3(1), ERBB4(1), GNAS(3), GRIN1(1), GRIN2A(3), GRIN2C(2), GRIN2D(2), GRM5(1), GRPR(3), HRH1(1), HTR2A(1), HTR2B(2), HTR4(1), HTR5A(1), ITPR1(2), ITPR2(4), ITPR3(4), MYLK(1), NOS1(1), NOS3(3), P2RX1(1), P2RX2(1), P2RX3(1), P2RX4(1), PDE1A(1), PDE1B(1), PDE1C(1), PDGFRA(7), PHKA2(2), PHKB(1), PLCB1(2), PLCB2(3), PLCB4(1), PLCD3(2), PLCE1(3), PLCG1(4), PLCG2(4), PLCZ1(1), PPP3R2(1), PRKACG(1), PRKCA(1), PRKCG(1), PTAFR(1), PTK2B(1), RYR1(7), RYR2(10), RYR3(3), SLC25A5(1), SLC8A3(2), TACR2(2), TACR3(1), VDAC3(2)	116292582	179	120	172	50	51	48	4	44	32	0	0.0633	1.000	1.000
557	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(2), ADRA1B(1), ADRB2(1), AGTR2(1), AVPR1A(2), BRS3(1), CALCR(1), CHRM1(1), CHRM3(3), CHRM5(1), CTSG(1), DRD5(3), F2(3), F2RL1(2), FPR1(1), FSHR(1), GABRA1(3), GABRA3(2), GABRA4(3), GABRA5(1), GABRA6(3), GABRB1(2), GABRB2(2), GABRB3(1), GABRE(2), GABRG2(1), GABRG3(1), GABRP(1), GALR1(1), GH1(1), GHR(1), GIPR(1), GLP2R(1), GLRA1(1), GLRB(1), GNRHR(1), GPR156(1), GPR35(1), GPR50(2), GPR83(1), GRIA1(5), GRIA3(4), GRID2(1), GRIK2(1), GRIK4(1), GRIN1(1), GRIN2A(3), GRIN2B(3), GRIN2C(2), GRIN2D(2), GRIN3A(1), GRM3(1), GRM4(3), GRM5(1), GRM6(2), GRM7(2), GRPR(3), HCRTR2(1), HRH1(1), HRH4(1), HTR1B(2), HTR1E(1), HTR2A(1), HTR2B(2), HTR4(1), HTR5A(1), MC3R(1), MC4R(1), MC5R(1), MCHR2(1), MTNR1A(1), NMBR(2), NMUR2(1), NPY1R(1), NPY2R(1), NR3C1(1), OPRD1(1), P2RX1(1), P2RX2(1), P2RX3(1), P2RX4(1), P2RY2(1), P2RY6(1), PPYR1(1), PTAFR(1), PTH2R(1), RXFP2(2), SCTR(1), SSTR2(1), SSTR3(2), SSTR4(5), TAAR5(1), TACR2(2), TACR3(1), THRA(1), TSHR(2), UTS2R(1)	95686409	147	109	147	46	56	36	2	34	19	0	0.0682	1.000	1.000
558	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(1), ACTG1(1), COL11A1(1), COL17A1(1), COL1A2(5), COL2A1(1), COL3A1(3), COL4A1(1), COL4A4(1), COL4A6(3), COL5A1(1), COL5A2(1), COL6A3(6), COL6A6(1), DSC1(1), DSC2(1), DSC3(2), DSG1(2), DSG2(3), DSG3(2), DSG4(1), GJA1(1), GJA3(1), GJA8(1), GJB2(1), GJB6(1), GJC3(1), IBSP(1), KRT15(2), KRT16(1), KRT17(1), KRT20(3), KRT27(1), KRT28(2), KRT3(3), KRT31(2), KRT33A(2), KRT33B(2), KRT34(1), KRT35(1), KRT36(1), KRT37(2), KRT39(1), KRT6B(1), KRT6C(2), KRT71(1), KRT73(2), KRT75(1), KRT76(1), KRT8(1), KRT83(2), KRT84(1), KRT86(1), KRT9(1), LAMA1(3), LAMA2(3), LAMA3(8), LAMA4(1), LAMA5(5), LAMB1(1), LAMB4(3), LAMC1(1), LAMC2(1), LAMC3(2), LMNA(1), LMNB2(1), NES(1), RELN(4), SPP1(1), THBS1(1), THBS2(1), THBS4(1), TNC(2), TNN(2), TNR(1), TNXB(4), VWF(3)	107479881	136	103	136	53	59	35	3	28	11	0	0.445	1.000	1.000
559	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR2A(2), BMPR1B(1), CCL20(1), CCR7(1), CD70(1), CNTFR(1), CRLF2(2), CSF2RA(3), CSF2RB(1), CXCL13(1), CXCL9(1), CXCR4(1), EDA(1), EDAR(3), EGF(3), EGFR(21), FASLG(1), FLT4(1), GH1(1), GHR(1), HGF(2), IFNA21(1), IFNA5(1), IFNAR1(2), IFNGR2(1), IL12B(1), IL12RB1(1), IL13RA1(1), IL15(1), IL17RA(1), IL18(2), IL19(1), IL1R1(1), IL1R2(1), IL20RA(1), IL22RA1(1), IL23R(1), IL2RB(2), IL4R(1), IL6(1), IL6ST(2), IL7R(1), IL9R(2), KDR(4), KIT(2), LIFR(1), LTBR(2), MET(4), OSMR(1), PDGFC(1), PDGFRA(7), TGFBR1(1), TGFBR2(1), TNF(1), TNFRSF10C(1), TNFRSF13B(1), TNFRSF14(1), TNFRSF6B(1), TNFRSF9(2), TNFSF14(1), TNFSF15(2), TNFSF8(1), TNFSF9(1), TPO(3), VEGFB(2), VEGFC(2), XCL1(1)	76428621	121	87	114	43	22	43	4	34	18	0	0.409	1.000	1.000
560	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	CD36(1), CD44(2), COL11A1(1), COL1A2(5), COL2A1(1), COL3A1(3), COL4A1(1), COL4A4(1), COL4A6(3), COL5A1(1), COL5A2(1), COL6A3(6), COL6A6(1), DAG1(1), FNDC1(2), FNDC3A(2), HSPG2(6), IBSP(1), ITGA10(1), ITGA11(2), ITGA2(1), ITGA2B(1), ITGA4(1), ITGA5(1), ITGA8(1), ITGB6(1), ITGB7(1), ITGB8(1), LAMA1(3), LAMA2(3), LAMA3(8), LAMA4(1), LAMA5(5), LAMB1(1), LAMB4(3), LAMC1(1), LAMC2(1), LAMC3(2), RELN(4), SDC1(1), SPP1(1), THBS1(1), THBS2(1), THBS4(1), TNC(2), TNN(2), TNR(1), TNXB(4), VWF(3)	96715339	99	80	99	39	38	33	3	17	8	0	0.394	1.000	1.000
561	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABLIM1(2), ABLIM3(2), ARHGEF12(1), CFL1(1), CXCR4(1), DCC(2), EFNB3(1), EPHA3(4), EPHA4(3), EPHA5(3), EPHA6(1), EPHA7(1), EPHA8(1), EPHB6(3), GNAI1(3), KRAS(1), L1CAM(1), LIMK1(3), LRRC4C(1), MAPK1(1), MET(4), NCK1(1), NFAT5(2), NFATC1(1), NFATC2(2), NFATC4(1), NGEF(1), NRAS(1), NTN4(1), NTNG1(1), PAK1(1), PAK4(1), PAK6(1), PAK7(1), PLXNA1(2), PLXNA2(1), PLXNA3(4), PLXNB1(1), PLXNB3(1), PPP3R2(1), RAC2(1), RASA1(2), RGS3(4), RHOD(1), ROBO1(1), ROBO3(4), ROCK2(1), SEMA3A(1), SEMA3B(1), SEMA3C(1), SEMA3E(1), SEMA3F(1), SEMA4A(1), SEMA4B(1), SEMA4F(1), SEMA6A(1), SEMA6B(2), SEMA6C(1), SEMA6D(2), SEMA7A(1), SLIT1(3), SLIT2(3), SLIT3(1), SRGAP1(1), SRGAP2(1)	85317113	103	77	101	34	26	28	6	24	19	0	0.337	1.000	1.000
562	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADCY9(2), ADK(1), ADSL(1), ADSSL1(1), AK7(4), AMPD2(2), CANT1(3), ENPP1(1), ENPP3(2), ENTPD5(1), ENTPD6(1), GART(1), GMPR(1), GMPR2(1), GUCY1A3(1), GUCY2C(2), GUCY2F(2), IMPDH2(1), NT5C(2), NT5E(1), PAICS(1), PDE11A(2), PDE1A(1), PDE1C(1), PDE2A(1), PDE4D(1), PDE7B(1), PDE8A(3), PFAS(1), PKLR(1), POLA1(2), POLD1(1), POLE(1), POLR1A(1), POLR2A(1), POLR2B(1), POLR2G(1), POLR3A(3), POLR3B(1), POLR3GL(1), POLR3K(1), PRIM1(1), PRIM2(2), PRPS1(1), PRPS1L1(1), PRPS2(1), RRM1(1), XDH(2)	70351650	75	66	74	24	28	18	4	12	13	0	0.241	1.000	1.000
563	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	CADM1(1), CD22(2), CD276(1), CD28(1), CD58(1), CDH1(1), CDH15(1), CDH4(4), CDH5(1), CLDN11(1), CLDN14(1), CLDN16(1), CLDN19(1), CNTN2(2), CNTNAP2(2), CTLA4(1), ESAM(1), HLA-DMB(1), HLA-DOA(1), HLA-DQA2(2), HLA-DRA(1), HLA-DRB5(2), HLA-F(2), HLA-G(2), ICAM1(1), ITGA4(1), ITGA8(1), ITGAL(2), ITGB2(1), ITGB7(1), ITGB8(1), JAM2(1), L1CAM(1), MAG(1), NCAM1(2), NEGR1(2), NEO1(2), NLGN1(1), NLGN2(1), NLGN3(3), NRCAM(2), NRXN1(1), NRXN3(1), PTPRC(3), PTPRF(2), PTPRM(2), PVR(2), PVRL3(1), SDC1(1), SELE(3), SELP(1), SELPLG(1), SIGLEC1(1), VCAN(3)	63752914	80	66	79	35	30	14	3	18	15	0	0.697	1.000	1.000
564	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA2(1), ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADCY9(2), ARRB2(1), ATF2(1), CACNB3(1), CNN2(1), CREB3(3), FOS(1), GJA1(1), GNB2(1), GNG12(1), GRK4(1), GUCY1A3(1), IGFBP2(1), IL6(1), ITPR1(2), ITPR2(4), ITPR3(4), NOS1(1), NOS3(3), PDE4D(1), PLCG1(4), PLCG2(4), PRKAR1A(2), PRKCA(1), PRKCH(1), PRKCQ(1), RGS19(1), RGS3(4), RGS6(1), RGS9(1), RLN1(1), RYR1(7), RYR2(10), RYR3(3), TNXB(4), YWHAH(1)	74679350	87	65	85	29	30	18	3	19	17	0	0.440	1.000	1.000
565	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	163	ADRA1B(1), ADRB2(1), AGTR2(1), AVPR1A(2), BRS3(1), CCR10(1), CCR7(1), CHRM1(1), CHRM3(3), CHRM5(1), CMKLR1(1), CXCR4(1), DRD5(3), F2RL1(2), FPR1(1), FSHR(1), GALR1(1), GPR17(1), GPR174(1), GPR35(1), GPR50(2), GPR83(1), GPR85(1), GPR87(1), GRPR(3), HCRTR2(1), HRH1(1), HTR1B(2), HTR1E(1), HTR2A(1), HTR2B(2), HTR4(1), HTR5A(1), MC3R(1), MC4R(1), MC5R(1), MTNR1A(1), NMBR(2), NMUR2(1), NPY1R(1), NPY2R(1), OPRD1(1), OR10A5(1), OR1C1(2), OR1Q1(1), P2RY12(2), P2RY2(1), P2RY6(1), PPYR1(1), PTAFR(1), SSTR2(1), SSTR3(2), SSTR4(5)	52556245	72	61	72	32	30	17	1	17	7	0	0.604	1.000	1.000
566	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA2(1), ACTN3(1), ACTN4(1), DMD(4), MYBPC2(2), MYH3(3), MYH6(2), MYH7(1), MYH8(6), MYOM1(1), NEB(10), TNNI1(1), TNNT1(1), TNNT3(2), TPM1(2), TPM2(1), TPM3(1), TTN(34)	58433085	74	60	73	30	31	15	1	19	8	0	0.702	1.000	1.000
567	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADCY9(2), AKAP3(1), AKAP4(4), AKAP5(1), AKAP6(3), AKAP8(2), AKAP9(4), GNAO1(3), GNB2(1), GNG12(1), ITPR1(2), KRAS(1), NRAS(1), PDE1A(1), PDE1B(1), PDE1C(1), PDE4D(1), PDE7B(1), PDE8A(3), PRKACG(1), PRKAR1A(2), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(1), RRAS(1)	50452271	50	47	50	17	18	8	1	10	13	0	0.536	1.000	1.000
568	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADCY1(1), ADCY2(1), ADCY3(1), ADCY4(3), ADCY5(1), ADCY7(1), ADK(1), ADSL(1), AMPD2(2), CANT1(3), ENPP1(1), ENPP3(2), GART(1), GUCY1A3(1), GUCY2C(2), GUCY2F(2), IMPDH2(1), NT5C(2), NT5E(1), PAICS(1), PDE1A(1), PDE4D(1), PDE6B(3), PDE6C(3), PDE7B(1), PDE8A(3), PFAS(1), PKLR(1), POLD1(1), POLE(1), POLQ(2), POLR2A(1), POLR2B(1), POLR2G(1), PRPS1(1), PRPS1L1(1), PRPS2(1), RRM1(1)	55286989	54	47	54	25	25	15	2	6	6	0	0.768	1.000	1.000
569	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	CAPN11(2), CAPN3(1), DOCK1(1), ITGA10(1), ITGA11(2), ITGA2(1), ITGA2B(1), ITGA4(1), ITGA5(1), ITGA8(1), ITGAD(1), ITGAE(1), ITGAL(2), ITGAX(1), ITGB2(1), ITGB6(1), ITGB7(1), ITGB8(1), MAP2K3(1), MAP2K6(1), MAPK12(1), MAPK4(1), MAPK7(3), PAK1(1), PAK4(1), PAK6(1), RAC2(1), RAPGEF1(2), ROCK2(1), SHC1(1), TLN1(3), VAV3(8), VCL(1)	57814027	48	43	41	18	13	7	0	14	14	0	0.826	1.000	1.000
570	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(1), CABIN1(2), CREBBP(4), CSNK2A1(1), CTLA4(1), FOS(1), GATA4(1), IL6(1), KPNA5(1), MAPK8(1), MAPK9(1), MYF5(1), NFAT5(2), NFATC1(1), NFATC2(2), NFATC4(1), OPRD1(1), PAK1(1), PTPRC(3), SLA(1), SP3(2), TNF(1), TRPV6(3), VAV1(3), VAV3(8)	39230584	45	41	38	17	12	11	1	6	15	0	0.738	1.000	1.000
571	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(2), ABCA10(1), ABCA12(1), ABCA13(6), ABCA2(1), ABCA3(1), ABCA4(3), ABCA6(2), ABCA7(4), ABCA8(1), ABCB1(3), ABCB10(2), ABCB4(3), ABCB7(1), ABCC10(3), ABCC12(1), ABCC3(1), ABCC9(1), ABCD2(1), ABCG1(1), ABCG4(2), ABCG5(1), ABCG8(1), CFTR(3)	50811373	46	39	46	25	11	13	3	10	9	0	0.928	1.000	1.000
572	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(5), ACSL1(3), ACSL4(1), ACSL6(1), ADIPOR1(1), CD36(1), G6PC(3), G6PC2(1), IRS1(2), IRS4(2), JAK2(1), JAK3(1), MAPK8(1), MAPK9(1), NFKBIA(1), NPY(2), PCK1(1), PPARGC1A(1), PRKAA1(1), PRKCQ(1), PTPN11(5), RXRA(1), RXRG(3), STAT3(1), TNF(1), TRADD(1), TYK2(2)	35856094	45	39	44	19	14	14	0	12	5	0	0.618	1.000	1.000
573	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CDC40(1), CLK4(1), COL2A1(1), CPSF2(1), CSTF1(1), CSTF2(1), CSTF3(1), DDIT3(1), DHX16(1), DHX38(2), FUS(1), LOC440563(1), METTL3(1), PAPOLA(1), POLR2A(1), PRPF18(1), PRPF8(2), PSKH1(1), RNGTT(1), SF3A3(1), SF3B1(2), SNRPB(1), SNRPB2(1), SNRPE(1), SNRPN(1), SPOP(2), SRPK2(1), SRRM1(1), TXNL4A(1), U2AF2(2), XRN2(2)	45547694	37	36	37	12	9	11	1	9	7	0	0.585	1.000	1.000
574	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ABP1(3), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), AOX1(2), CYP1A2(2), CYP2B6(1), CYP2C19(5), CYP2C8(1), CYP3A4(2), CYP3A7(1), CYP4F8(1), DDC(1), ECHS1(1), HADHA(2), TDO2(1), WARS2(1)	23701880	32	28	32	13	15	7	0	5	5	0	0.598	1.000	1.000
575	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACOX3(1), ACSL1(3), ACSL4(1), ACSL6(1), APOA1(1), CD36(1), CYP4A11(1), CYP4A22(1), CYP8B1(1), FADS2(1), GK(1), GK2(3), LPL(1), MMP1(1), NR1H3(1), PCK1(1), PPARG(1), RXRA(1), RXRG(3), SLC27A4(1), UBC(2)	28202668	28	27	28	11	4	12	1	7	4	0	0.571	1.000	1.000
576	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP4(2), CSNK1A1L(1), CSNK1G1(1), CSNK1G2(1), GLI1(1), GLI3(1), HHIP(1), LRP2(8), PRKACG(1), PTCH1(1), RAB23(1), SHH(1), STK36(1), SUFU(1), WNT11(2), WNT16(1), WNT2(1), WNT7A(1), WNT8A(1), WNT9B(1)	26321149	29	25	29	14	12	8	1	3	5	0	0.795	1.000	1.000
577	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPP(4), ALPPL2(2), DDX4(2), DDX51(2), DDX52(1), DDX55(1), DDX56(1), FPGS(2), IFIH1(2), MOV10L1(1), QDPR(1), RAD54L(1), RUVBL2(1), SETX(3), SKIV2L2(1), SPR(1)	27040912	26	24	26	10	9	6	1	5	5	0	0.680	1.000	1.000
578	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	ARSD(1), ARSE(1), CYP11B1(1), HSD3B2(1), PRMT5(2), PRMT8(1), SRD5A1(1), SULT2B1(2), UGT1A1(3), UGT2A3(1), UGT2B10(4), UGT2B11(3), UGT2B28(2), UGT2B4(1), UGT2B7(1)	21639294	25	23	25	10	5	5	1	13	1	0	0.710	1.000	1.000
579	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS2(1), CP(1), EPRS(1), FTH1(1), HCCS(2), PPOX(1), UGT1A1(3), UGT2A3(1), UGT2B10(4), UGT2B11(3), UGT2B28(2), UGT2B4(1), UGT2B7(1)	18203707	22	21	22	10	2	7	0	13	0	0	0.843	1.000	1.000
580	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(3), ALDH1A1(1), ALDH1A3(1), ALDH1B1(2), ALDH3A1(3), ALDH4A1(1), ASL(1), CPS1(2), GLUD1(2), NOS1(1), NOS3(3), RARS(1)	19098778	21	20	21	14	8	5	0	3	5	0	0.960	1.000	1.000
581	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	CALR(1), CIITA(1), HLA-DMB(1), HLA-DOA(1), HLA-DQA2(2), HLA-DRA(1), HLA-DRB5(2), HLA-F(2), HLA-G(2), IFNA21(1), IFNA5(1), KIR2DL1(3), KLRC2(1), RFXANK(1)	19913781	20	20	20	10	4	4	2	7	3	0	0.829	1.000	1.000
582	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(3), AGXT2(1), ALAS2(1), DMGDH(1), GARS(1), GLDC(1), PLCB2(3), PLCG1(4), PLCG2(4), PSPH(1)	18166996	20	19	19	10	8	6	0	4	2	0	0.800	1.000	1.000
583	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(1), ASL(1), ASS1(1), CPS1(2), EPRS(1), GLUD1(2), GLUD2(1), NOS1(1), NOS3(3), RARS(1), RARS2(2)	15521148	16	15	16	10	3	5	0	5	3	0	0.955	1.000	1.000
584	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(2), GPRC5C(1), GPRC5D(2), GRM3(1), GRM4(3), GRM5(1), GRM7(2)	9051312	12	12	12	8	9	1	0	2	0	0	0.891	1.000	1.000
585	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(3), AGXT2(1), ALAS2(1), DMGDH(1), GARS(1), GLDC(1), HSD3B7(1), PHGDH(2), PSPH(1)	18444475	12	12	12	10	3	3	0	5	1	0	0.973	1.000	1.000
586	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	ARSD(1), ARSE(1), CYP11B1(1), HSD3B2(1), SRD5A1(1), UGT1A1(3), UGT2B4(1)	11786478	9	9	9	5	3	1	0	5	0	0	0.867	1.000	1.000
587	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC2(1), ANAPC7(1), CDC16(1), CUL1(1), FBXW7(1), FZR1(1), SKP2(1), SMURF2(1), UBE2D4(1)	17280108	9	9	9	9	1	4	1	3	0	0	0.993	1.000	1.000
588	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1), DCN(1), FMOD(1), KERA(3), LUM(1)	1563894	7	7	7	5	1	3	0	3	0	0	0.889	1.000	1.000
589	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	ARHGDIB(1), CASP1(1), CYCS(1), PRF1(1)	5538024	4	4	4	3	1	1	0	2	0	0	0.934	1.000	1.000
590	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	MYLK(1), PLCB1(2), PRKCA(1)	8878408	4	4	4	4	2	0	0	2	0	0	0.962	1.000	1.000
591	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(1), POLD1(1), PRPS2(1), RRM1(1)	5384326	4	4	4	3	2	2	0	0	0	0	0.838	1.000	1.000
592	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	RELN(4)	6036684	4	4	4	3	1	3	0	0	0	0	0.833	1.000	1.000
593	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(1), POLE(1), POLQ(2)	7174802	4	3	4	5	4	0	0	0	0	0	0.984	1.000	1.000
594	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(1), EIF2AK4(1), EIF2S2(1)	4956168	3	3	3	3	1	0	1	1	0	0	0.939	1.000	1.000
595	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	CYCS(1), FASLG(1), TNF(1)	4880765	3	3	3	4	0	1	0	2	0	0	0.995	1.000	1.000
596	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	IL6(1), STAT3(1), TNF(1)	5237079	3	3	3	3	1	1	0	1	0	0	0.951	1.000	1.000
597	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR2A(1), POLR2B(1), POLR2G(1)	5833305	3	3	3	3	1	2	0	0	0	0	0.903	1.000	1.000
598	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	DNMT1(1), MTNR1A(1), PTAFR(1)	4823811	3	3	3	3	2	1	0	0	0	0	0.929	1.000	1.000
599	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGEF2(2)	6984804	2	2	2	2	0	1	1	0	0	0	0.907	1.000	1.000
600	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	GPR34(1), GPR45(1)	4225350	2	2	2	3	1	1	0	0	0	0	0.945	1.000	1.000
601	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD58(1), IL6(1)	2654615	2	2	2	2	0	0	0	2	0	0	0.951	1.000	1.000
602	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	HLA-DRA(1), IL6(1)	2299642	2	2	2	2	0	0	0	2	0	0	0.952	1.000	1.000
603	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	MAPK8(1), TNFRSF13B(1)	6273334	2	2	2	2	0	2	0	0	0	0	0.893	1.000	1.000
604	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	14	IL6(1)	3504419	1	1	1	4	0	0	0	1	0	0	0.998	1.000	1.000
605	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	14	IL6(1)	2564187	1	1	1	2	0	0	0	1	0	0	0.979	1.000	1.000
606	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14		4992904	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
607	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9		3754891	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
608	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1		311704	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
609	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		219003	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
610	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4		1325492	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
611	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		656813	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
612	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11		3998853	0	0	0	3	0	0	0	0	0	0	1.000	1.000	1.000
613	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3		736382	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
614	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17		3758025	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
615	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7		2628571	0	0	0	2	0	0	0	0	0	0	1.000	1.000	1.000
616	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3		490549	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
