Clinical Features CN_CNMF METHLYATION_CNMF RPPA_CNMF RPPA_CHIERARCHICAL MRNASEQ_CNMF MRNASEQ_CHIERARCHICAL MIRSEQ_CNMF MIRSEQ_CHIERARCHICAL MIRSEQ_MATURE_CNMF MIRSEQ_MATURE_CHIERARCHICAL nMutated (%) nWild-Type Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q ZFPM1 24 (39%) 38 0.80129 1 0.81627 1 0.71582 1 0.87168 1 0.37475 1 0.74459 1 0.8215 1 0.9225 1 0.38151 1 0.74173 1 LACTB 19 (31%) 43 0.43646 1 0.69064 1 0.65998 1 0.56607 1 1 1 0.31608 1 0.37753 1 0.75224 1 0.32038 1 0.17846 1 CCDC102A 17 (27%) 45 0.01901 1 0.93583 1 0.88012 1 0.50675 1 0.97466 1 0.82576 1 0.49723 1 0.46941 1 0.80534 1 0.50653 1 ZNF517 13 (21%) 49 0.16638 1 0.98003 1 NA NA NA NA 0.81964 1 0.95119 1 0.17302 1 0.69819 1 0.72649 1 0.7725 1 MAL2 11 (18%) 51 0.49933 1 0.31303 1 0.20877 1 1 1 0.25318 1 0.50941 1 0.21794 1 0.26836 1 1 1 0.86748 1 CLDN23 10 (16%) 52 0.57171 1 0.24908 1 1 1 0.34917 1 0.02969 1 0.2111 1 0.098449 1 0.18182 1 0.41647 1 0.54226 1 TOR3A 12 (19%) 50 0.61021 1 0.01363 1 0.13795 1 0.31545 1 0.67853 1 0.005 1 1 1 0.84448 1 0.91198 1 0.8078 1 USP42 15 (24%) 47 0.5485 1 0.04692 1 1 1 0.46582 1 1 1 0.96027 1 0.45655 1 0.8726 1 0.91127 1 0.9025 1 TP53 12 (19%) 50 0.13303 1 0.79251 1 0.067989 1 0.4658 1 0.02013 1 0.66655 1 0.01582 1 0.67203 1 0.0061399 1 0.17817 1 APOE 7 (11%) 55 1 1 0.59291 1 0.58914 1 0.38382 1 0.060159 1 0.40086 1 0.19465 1 0.79052 1 0.4156 1 1 1 ZAR1 11 (18%) 51 0.64452 1 0.66963 1 0.20939 1 0.79255 1 0.62361 1 0.86863 1 0.71587 1 0.97182 1 1 1 0.60298 1 ASPDH 8 (13%) 54 0.30067 1 0.68819 1 0.71653 1 0.31426 1 0.02364 1 0.39771 1 0.47364 1 0.03102 1 0.21327 1 0.080999 1 KCNK17 9 (15%) 53 0.20103 1 0.03909 1 0.17899 1 0.43906 1 0.10433 1 0.0094199 1 0.89147 1 0.54797 1 0.71668 1 0.44423 1 LZTR1 6 (10%) 56 0.051729 1 0.85066 1 NA NA NA NA 0.089639 1 0.1197 1 0.40128 1 0.01432 1 1 1 0.45293 1 ERCC2 10 (16%) 52 1 1 0.23243 1 0.21848 1 0.23278 1 0.4816 1 0.17215 1 0.59736 1 0.26787 1 0.33653 1 0.20732 1 RINL 8 (13%) 54 0.33913 1 0.67755 1 0.52797 1 0.57862 1 0.46409 1 0.27276 1 0.7601 1 0.16937 1 0.34498 1 0.74794 1 SYT8 8 (13%) 54 0.44315 1 0.44105 1 1 1 1 1 0.04155 1 0.17657 1 1 1 0.18489 1 0.75075 1 0.49568 1 LRIG1 16 (26%) 46 0.54233 1 0.95968 1 0.21134 1 1 1 0.86526 1 0.61092 1 0.36161 1 0.43466 1 0.57737 1 0.90222 1 C1ORF106 9 (15%) 53 0.84297 1 0.47146 1 0.16406 1 0.04752 1 0.34025 1 0.76125 1 0.47403 1 0.6927 1 0.052979 1 1 1 GPRIN2 8 (13%) 54 0.86749 1 0.3813 1 0.21045 1 0.69321 1 0.68221 1 0.40159 1 0.57775 1 0.75381 1 0.59396 1 0.18263 1 CTNNB1 7 (11%) 55 0.73091 1 0.1849 1 0.21098 1 0.39529 1 0.01765 1 0.02351 1 0.00078999 0.767 0.17519 1 0.12536 1 0.7127 1 C16ORF3 5 (8%) 57 0.85814 1 0.00075999 0.739 0.59044 1 0.7878 1 0.80041 1 0.8148 1 0.58167 1 1 1 0.72618 1 0.83502 1 CCDC105 6 (10%) 56 1 1 0.0109 1 0.58843 1 0.67646 1 0.93757 1 0.79458 1 1 1 0.053549 1 0.21734 1 0.20754 1 RGS9BP 8 (13%) 54 0.72674 1 0.6315 1 1 1 0.12772 1 1 1 0.93362 1 0.21808 1 0.962 1 0.34298 1 0.75354 1 HHIPL1 6 (10%) 56 0.27604 1 0.43367 1 NA NA NA NA 0.63147 1 0.51287 1 0.20677 1 0.42249 1 0.20065 1 0.33273 1 C10ORF95 6 (10%) 56 0.19915 1 0.3783 1 NA NA NA NA 0.5128 1 1 1 0.48481 1 0.35556 1 1 1 1 1 TSC22D2 8 (13%) 54 0.94703 1 0.54149 1 0.76735 1 0.95442 1 0.78021 1 0.81702 1 0.76142 1 0.42895 1 0.34992 1 1 1 NOXA1 5 (8%) 57 0.14516 1 0.51358 1 NA NA NA NA 0.22239 1 0.4425 1 0.29335 1 0.35314 1 0.25193 1 0.72224 1 THEM4 5 (8%) 57 0.28129 1 0.76924 1 NA NA NA NA 0.43966 1 0.87565 1 0.17909 1 0.10663 1 0.23173 1 0.26083 1 ATXN1 10 (16%) 52 0.55553 1 0.13892 1 0.88724 1 0.91517 1 0.23605 1 0.65792 1 0.28533 1 0.87074 1 0.23544 1 0.31477 1 PLIN5 5 (8%) 57 0.49862 1 0.69608 1 0.45417 1 0.38541 1 0.80031 1 0.66723 1 0.26806 1 0.26472 1 0.51072 1 0.04648 1 OPRD1 12 (19%) 50 0.96814 1 0.43357 1 0.27996 1 0.4782 1 0.7986 1 0.95955 1 0.30003 1 0.61416 1 1 1 0.51017 1 KRTAP4-5 5 (8%) 57 0.63174 1 0.28562 1 NA NA NA NA 0.90924 1 0.87624 1 1 1 0.84342 1 0.43509 1 1 1 C19ORF10 7 (11%) 55 0.78184 1 0.42338 1 0.88652 1 0.38987 1 0.24079 1 0.12416 1 0.55087 1 0.86152 1 0.63826 1 0.71518 1 AATK 6 (10%) 56 0.13862 1 0.33073 1 NA NA NA NA 0.4407 1 0.35629 1 1 1 0.5443 1 1 1 0.61965 1 SARM1 6 (10%) 56 0.20777 1 0.4217 1 0.88591 1 0.694 1 0.17383 1 0.11423 1 0.26601 1 0.83588 1 0.51166 1 0.079279 1 TRIOBP 10 (16%) 52 0.62041 1 0.2292 1 0.45264 1 0.12812 1 1 1 0.11242 1 0.71251 1 0.87084 1 1 1 0.77445 1 ZNF598 12 (19%) 50 0.11076 1 0.31624 1 0.42676 1 0.75046 1 0.48883 1 0.95271 1 1 1 0.22573 1 0.90087 1 1 1 WDR34 5 (8%) 57 0.63277 1 0.83061 1 NA NA NA NA 0.8629 1 0.81509 1 0.8421 1 0.55111 1 0.8422 1 0.33552 1 ZNF628 7 (11%) 55 0.21034 1 0.92692 1 0.5908 1 0.67468 1 0.3129 1 0.11655 1 0.094659 1 0.50274 1 0.28592 1 0.54492 1 BTBD11 6 (10%) 56 1 1 0.31533 1 NA NA NA NA 0.48398 1 1 1 0.48771 1 0.18326 1 0.72558 1 0.32963 1 IRX3 5 (8%) 57 0.14111 1 0.70661 1 NA NA NA NA 0.52243 1 0.1199 1 0.17913 1 0.77885 1 0.23054 1 0.45329 1 FPGS 5 (8%) 57 1 1 1 1 0.45164 1 0.3508 1 0.66486 1 0.60107 1 0.055269 1 0.62714 1 0.82207 1 0.61981 1 MEN1 5 (8%) 57 0.41813 1 0.04867 1 NA NA NA NA 0.01314 1 0.0068299 1 0.20635 1 0.04262 1 0.1363 1 0.20113 1 BHLHE22 5 (8%) 57 0.42538 1 0.071939 1 0.88858 1 0.91639 1 0.11979 1 0.81671 1 0.58214 1 0.83598 1 0.72679 1 0.83622 1 DMKN 3 (5%) 59 1 1 0.32475 1 NA NA NA NA 0.61705 1 0.44076 1 0.0062199 1 0.56842 1 0.25403 1 1 1 OBSCN 18 (29%) 44 0.30998 1 0.51987 1 1 1 0.54469 1 0.67171 1 0.80679 1 0.14838 1 0.49779 1 1 1 0.38603 1 PANK2 5 (8%) 57 0.62783 1 0.43145 1 0.45052 1 0.34847 1 0.11492 1 0.051969 1 0.42921 1 0.34974 1 1 1 0.25526 1 RREB1 5 (8%) 57 0.72729 1 0.85084 1 NA NA NA NA 0.6191 1 1 1 0.52799 1 0.54667 1 0.17381 1 0.35223 1 RNF149 4 (6%) 58 0.33873 1 0.03673 1 0.76581 1 0.95381 1 0.43737 1 0.60004 1 0.31769 1 0.25856 1 0.66314 1 0.17435 1 GLTPD2 6 (10%) 56 0.8773 1 0.84246 1 NA NA NA NA 0.82866 1 0.39872 1 0.5512 1 0.53084 1 0.87273 1 0.13174 1 SNED1 5 (8%) 57 0.62939 1 0.31365 1 NA NA NA NA 0.40019 1 0.66612 1 0.094269 1 0.66165 1 1 1 0.5435 1 TPO 12 (19%) 50 0.26233 1 0.30262 1 0.8868 1 0.69661 1 0.17426 1 0.12512 1 0.098109 1 0.34138 1 1 1 0.16965 1 PTPLA 4 (6%) 58 0.41812 1 0.32498 1 NA NA NA NA 0.33614 1 0.44335 1 0.77648 1 1 1 0.77438 1 1 1 PRSS27 3 (5%) 59 1 1 0.90961 1 NA NA NA NA 0.61948 1 0.050559 1 0.13096 1 1 1 0.61401 1 0.5569 1 CD320 4 (6%) 58 1 1 0.85277 1 NA NA NA NA 0.73788 1 0.65859 1 0.39992 1 0.22521 1 0.23156 1 0.26076 1 SEMA5B 8 (13%) 54 0.34176 1 0.26878 1 0.62442 1 0.1741 1 0.3974 1 0.21469 1 0.64994 1 0.29901 1 0.36192 1 0.40787 1 CCDC150 4 (6%) 58 0.18002 1 0.85128 1 1 1 0.60066 1 0.23806 1 0.11693 1 0.40026 1 0.2095 1 1 1 0.45411 1 TAF5 4 (6%) 58 1 1 0.76915 1 1 1 0.95344 1 1 1 0.87709 1 0.0092599 1 0.11516 1 0.055489 1 0.01408 1 GARS 19 (31%) 43 0.075359 1 0.092179 1 0.38148 1 0.33485 1 0.34097 1 0.1023 1 0.11845 1 0.40171 1 0.21351 1 0.39942 1 MUC5B 22 (35%) 40 1 1 0.63056 1 0.53038 1 0.80908 1 0.73311 1 0.66974 1 0.71518 1 0.61717 1 1 1 0.53104 1 KIAA1984 4 (6%) 58 0.41815 1 0.70904 1 0.45086 1 0.50522 1 0.12673 1 0.04934 1 0.03135 1 0.58086 1 0.66469 1 0.79304 1 SRPX 3 (5%) 59 0.75302 1 0.11151 1 NA NA NA NA 0.61828 1 1 1 0.77576 1 0.71755 1 1 1 0.40118 1 TNIP2 5 (8%) 57 0.6294 1 0.70841 1 NA NA NA NA 0.73941 1 0.87625 1 1 1 0.41416 1 1 1 0.45274 1 IDUA 8 (13%) 54 0.3811 1 0.8544 1 0.52833 1 0.79361 1 0.50804 1 0.54613 1 0.20223 1 0.43215 1 0.45732 1 0.64505 1 RNF39 5 (8%) 57 0.7259 1 0.37972 1 0.25315 1 0.79362 1 0.1764 1 0.26629 1 0.15824 1 0.6984 1 0.23867 1 0.68561 1 PABPC1 4 (6%) 58 0.4166 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA SCRT1 3 (5%) 59 1 1 0.43005 1 NA NA NA NA 0.47389 1 0.61617 1 0.42644 1 0.7949 1 0.46823 1 1 1 MAP1S 5 (8%) 57 0.15757 1 0.2769 1 0.21019 1 0.4204 1 0.40071 1 1 1 1 1 0.83477 1 0.42031 1 0.83718 1 NF1 7 (11%) 55 0.2512 1 0.90323 1 0.88877 1 0.39163 1 0.35892 1 0.19244 1 0.28152 1 0.88548 1 1 1 0.096649 1 AKAP2 4 (6%) 58 0.10585 1 0.43501 1 0.45396 1 0.67594 1 0.74048 1 0.17183 1 0.52739 1 0.44648 1 0.82385 1 0.34889 1 NOTCH2 5 (8%) 57 0.27873 1 0.89536 1 NA NA NA NA 0.5239 1 0.11839 1 0.03102 1 0.318 1 0.66453 1 0.795 1 FANK1 4 (6%) 58 1 1 0.32349 1 NA NA NA NA 0.85694 1 0.28893 1 0.77667 1 0.23481 1 0.7741 1 0.25363 1 NEFH 6 (10%) 56 0.052289 1 0.17476 1 NA NA NA NA 0.11581 1 0.050949 1 0.39916 1 0.20979 1 0.66309 1 0.45188 1 NPTX1 3 (5%) 59 0.63817 1 1 1 NA NA NA NA 1 1 0.81713 1 0.58121 1 0.79397 1 0.35178 1 0.55805 1 KBTBD13 9 (15%) 53 0.45716 1 0.11667 1 1 1 0.79057 1 0.68601 1 0.11527 1 1 1 0.32898 1 1 1 0.6046 1 RASIP1 6 (10%) 56 0.36071 1 0.34973 1 NA NA NA NA 0.04035 1 0.18789 1 0.055849 1 0.69955 1 0.41678 1 0.71211 1 AR 4 (6%) 58 0.41638 1 0.51604 1 1 1 0.95428 1 0.47361 1 0.44695 1 0.42991 1 1 1 0.25433 1 1 1 KNDC1 9 (15%) 53 0.35321 1 0.066629 1 0.45158 1 0.55255 1 0.02552 1 0.32783 1 0.42056 1 0.36527 1 0.18717 1 0.38458 1 SEZ6L2 8 (13%) 54 0.38054 1 0.66655 1 0.45073 1 0.79125 1 0.82868 1 1 1 0.46531 1 0.62838 1 1 1 0.85242 1 VARS 6 (10%) 56 1 1 0.42242 1 0.45259 1 0.38595 1 0.21641 1 0.065969 1 0.64599 1 0.86247 1 0.75036 1 1 1 IER5 3 (5%) 59 0.20005 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NMU 5 (8%) 57 0.91452 1 1 1 NA NA NA NA 0.069069 1 0.61257 1 1 1 0.54625 1 0.82325 1 0.62093 1 TMEM189 3 (5%) 59 0.19981 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA ADAD2 4 (6%) 58 0.41942 1 0.57463 1 NA NA NA NA 0.7381 1 0.1732 1 0.0096599 1 0.51183 1 0.056849 1 0.35174 1 PLEC 13 (21%) 49 0.42794 1 0.67053 1 0.19687 1 0.04863 1 0.20435 1 0.71944 1 0.59614 1 0.6334 1 0.14048 1 0.6249 1 RGMB 6 (10%) 56 0.65102 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA CLIC6 5 (8%) 57 0.63101 1 1 1 NA NA NA NA 0.66487 1 0.11838 1 0.17761 1 0.58303 1 0.29353 1 1 1 ZNF814 3 (5%) 59 1 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA DSPP 9 (15%) 53 0.6101 1 0.059689 1 0.88772 1 0.69324 1 1 1 0.48432 1 0.44609 1 0.53998 1 0.9006 1 1 1 AMDHD1 10 (16%) 52 0.65532 1 0.75806 1 1 1 0.3512 1 0.58827 1 0.13806 1 0.17273 1 0.85202 1 0.90123 1 0.68289 1 CRIPAK 10 (16%) 52 0.38538 1 0.92891 1 0.88671 1 0.93467 1 0.48972 1 0.68673 1 0.89537 1 0.33013 1 0.47652 1 0.36424 1 NOM1 6 (10%) 56 1 1 0.31351 1 NA NA NA NA 0.86547 1 1 1 1 1 0.78773 1 0.42178 1 1 1 MAP7 3 (5%) 59 1 1 0.653 1 NA NA NA NA 1 1 0.81256 1 0.58099 1 0.79345 1 1 1 0.55321 1 PTX4 3 (5%) 59 1 1 1 1 NA NA NA NA 0.47195 1 0.19454 1 0.43049 1 1 1 0.25271 1 0.2553 1 LRP11 6 (10%) 56 1 1 0.079699 1 NA NA NA NA 0.8003 1 0.66412 1 0.58145 1 0.93554 1 0.84205 1 0.83826 1 PDCD6 3 (5%) 59 0.29913 1 0.65105 1 NA NA NA NA NA NA NA NA 1 1 0.64084 1 1 1 1 1 SHOX2 3 (5%) 59 0.41276 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA UQCRFS1 5 (8%) 57 0.75028 1 0.58655 1 NA NA NA NA 1 1 0.87574 1 0.48895 1 0.20246 1 0.84251 1 0.33385 1 CTBP2 3 (5%) 59 0.75389 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA PRKAR1A 6 (10%) 56 0.61788 1 1 1 0.88635 1 0.7927 1 0.27838 1 0.40311 1 0.10512 1 0.58645 1 0.04932 1 0.58798 1 JMJD4 3 (5%) 59 1 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA HSD17B1 4 (6%) 58 0.91377 1 0.04788 1 0.76491 1 0.50815 1 0.91001 1 0.0081999 1 1 1 0.84273 1 0.54947 1 0.79586 1 COQ2 5 (8%) 57 0.36116 1 0.76786 1 NA NA NA NA 0.43777 1 0.59874 1 1 1 0.67279 1 0.54696 1 0.61677 1 FEZ2 3 (5%) 59 0.46658 1 0.35411 1 NA NA NA NA 0.22192 1 0.81447 1 0.19596 1 0.79493 1 0.7758 1 0.55609 1 DLEU7 3 (5%) 59 0.52815 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA RNF135 3 (5%) 59 0.75559 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA SPIRE2 3 (5%) 59 0.29998 1 0.03857 1 NA NA NA NA 1 1 0.81424 1 1 1 0.79548 1 1 1 1 1 KRTAP5-5 3 (5%) 59 1 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA SGK223 3 (5%) 59 0.75448 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA C9ORF66 5 (8%) 57 1 1 0.92481 1 NA NA NA NA 1 1 0.51207 1 0.58053 1 0.93592 1 0.34953 1 0.54101 1 AQP7 3 (5%) 59 0.75505 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA ADAMTS7 4 (6%) 58 0.19715 1 0.47667 1 0.01241 1 0.34993 1 0.090549 1 0.43811 1 0.082369 1 0.25824 1 0.12362 1 0.0387 1 PCDHB13 5 (8%) 57 0.395 1 0.14136 1 NA NA NA NA 0.12746 1 0.35599 1 0.66312 1 0.059649 1 0.43606 1 0.45301 1 CSGALNACT2 3 (5%) 59 0.16142 1 0.0388 1 NA NA NA NA 0.77419 1 0.81233 1 0.58303 1 0.87595 1 0.35154 1 0.40086 1 HLA-A 3 (5%) 59 1 1 1 1 NA NA NA NA 0.85242 1 0.19409 1 1 1 0.50575 1 0.77538 1 0.25366 1 MTFMT 3 (5%) 59 1 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NLRP5 4 (6%) 58 0.91419 1 0.17058 1 NA NA NA NA 1 1 0.12119 1 0.77823 1 0.64252 1 1 1 0.076049 1 KCNJ11 4 (6%) 58 0.01914 1 0.70919 1 NA NA NA NA 0.43636 1 0.2297 1 0.12555 1 0.053419 1 0.29139 1 0.25926 1