rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(1), ALPP(1), ALPPL2(8), FPGS(14), SPR(1) 921600 25 23 7 2 0 9 3 13 0 0 0.0413 1.37e-13 8.45e-11 2 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(1), PRDX1(1), PRDX2(2), TPO(22) 1336570 26 25 7 2 3 0 21 0 2 0 0.0159 2.90e-09 8.93e-07 3 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(1), TPO(22) 1154920 23 22 4 2 2 0 21 0 0 0 0.0181 3.81e-08 7.82e-06 4 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF3(1), CDKN2A(2), MDM2(2), TP53(18) 1124314 23 18 23 2 2 0 7 1 12 1 0.105 3.25e-07 5.00e-05 5 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ATP6V0C(1), EPX(1), PRDX1(1), PRDX2(2), SHMT2(1), TPO(22) 1628686 28 27 9 3 4 0 22 0 2 0 0.0251 4.17e-07 5.13e-05 6 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(1), DAXX(4), PML(2), RARA(1), RB1(2), SIRT1(1), TNFRSF1A(1), TP53(18) 2553179 30 24 30 2 3 1 7 1 17 1 0.0464 6.15e-07 6.31e-05 7 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 NFKB1(1), TP53(18) 1391271 19 17 19 1 2 0 5 1 10 1 0.122 2.32e-06 0.000204 8 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(5), ATR(3), CHEK2(2), TP53(18) 2105624 28 24 28 4 3 0 6 3 15 1 0.479 2.99e-06 0.000221 9 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(1), ATM(5), MDM2(2), RB1(2), TIMP3(1), TP53(18) 2416850 29 23 29 3 2 0 6 1 19 1 0.214 3.22e-06 0.000221 10 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(1), GNAS(5), GNB1(2), PRKACA(1), PRKAR1A(7) 921215 16 15 15 2 1 0 3 2 10 0 0.512 4.70e-05 0.00270 11 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(5), RB1(2), TP53(18) 2370899 25 22 25 6 2 0 5 1 16 1 0.785 4.82e-05 0.00270 12 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(1), IDI1(5), SQLE(2) 449336 8 8 5 0 0 1 7 0 0 0 0.120 9.74e-05 0.00500 13 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 EPX(1), MTHFR(1), SHMT2(1), TPO(22) 1583527 25 24 6 4 4 0 21 0 0 0 0.0698 0.000111 0.00525 14 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 CDKN2A(2), MDM2(2), PIK3CA(1), PIK3R1(1), POLR1A(1), POLR1C(2), RB1(2), TBX2(1), TP53(18) 2722048 30 24 30 4 3 0 10 2 14 1 0.162 0.000137 0.00604 15 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 AOC3(1), EPX(1), GOT1(1), GOT2(2), MAOA(3), PRDX1(1), PRDX2(2), TPO(22) 3047226 33 30 14 4 6 0 23 0 4 0 0.0222 0.000170 0.00698 16 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 GALNS(1), GNS(2), HEXB(1), IDS(1), IDUA(14), LCT(1) 2002396 20 17 10 2 4 1 1 14 0 0 0.0861 0.000427 0.0160 17 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 APC(4), CD14(1), CTNNB1(14), DVL1(1), FZD1(6), GJA1(2), IRAK1(2), LBP(1), NFKB1(1), PIK3CA(1), PIK3R1(1), TLR4(3), WNT1(2) 4208091 39 29 28 3 0 1 14 11 13 0 0.0886 0.000443 0.0160 18 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(4), CTNNB1(14), DLL1(1), DVL1(1), FZD1(6), NOTCH1(4), WNT1(2) 3007948 32 25 21 4 1 1 9 7 14 0 0.393 0.000534 0.0174 19 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(1), IDI1(5), SQLE(2) 590510 8 8 5 0 0 1 7 0 0 0 0.123 0.000536 0.0174 20 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(2), ACTN2(2), BCAR1(1), CSK(1), CTNNA2(1), CTNNB1(14) 2698910 21 20 16 2 1 1 9 6 4 0 0.135 0.00244 0.0753 21 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(1), ATM(5), IGFBP3(1), MDM2(2), TP53(18) 2829201 27 20 27 8 3 0 6 2 15 1 0.814 0.00446 0.131 22 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ATM(5), CHEK2(2), MDM2(2), MRE11A(1), NFKB1(1), RAD50(3), RAD51(1), RBBP8(1), TP53(18), TP73(1) 3999822 35 25 35 5 3 0 10 3 18 1 0.341 0.00565 0.152 23 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(1), GNAS(5), GNB1(2), PRKAA2(1), PRKACB(1), PRKAG2(3), PRKAR1A(7) 2127011 20 17 19 3 2 1 4 2 11 0 0.461 0.00567 0.152 24 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 42 APAF1(1), BCL2L1(2), CASP8(1), FADD(2), GZMB(1), MAP3K1(2), MDM2(2), NFKB1(1), PARP1(3), TNFRSF1A(1), TP53(18) 5098871 34 25 34 4 6 1 11 1 14 1 0.0724 0.0161 0.398 25 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(1), HSD17B1(5), HSD17B4(3), HSD17B7(2) 1097614 11 9 7 2 6 0 3 1 1 0 0.260 0.0161 0.398 26 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(1), CFTR(2), GNAS(5), PRKACB(1), PRKAR1A(7), SLC9A3R1(1) 1809713 17 14 16 3 1 0 3 2 11 0 0.584 0.0182 0.432 27 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(1), CD3D(1), GZMB(1), HLA-A(4), ICAM1(1), ITGAL(1) 1191900 9 9 8 1 3 0 2 2 2 0 0.300 0.0219 0.489 28 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(1), GNAS(5), GNB1(2), PRKACB(1), PRKAR1A(7) 1362033 16 14 15 3 1 0 3 2 10 0 0.663 0.0222 0.489 29 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 APAF1(1), ATM(5), BCL2L1(2), TLN1(2), TP53(18) 3704416 28 22 28 6 4 0 6 1 16 1 0.610 0.0271 0.575 30 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2I(1), GTF2IRD1(1), STON1(1), TAF1(5), TAF1L(1), TAF4(1), TAF4B(1), TAF5(12), TAF7L(1), TBPL2(1) 4850336 25 21 14 1 2 0 8 13 2 0 0.0150 0.0293 0.602 31 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), FDFT1(1), HMGCR(1), IDI1(5), NQO2(1), SQLE(2) 1558700 11 10 8 1 0 1 8 0 2 0 0.212 0.0315 0.625 32 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 DHCR7(1), FDFT1(1), HMGCR(1), IDI1(5), NSDHL(1), SQLE(2) 1843221 11 11 8 1 0 1 8 1 1 0 0.236 0.0350 0.673 33 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(2), MAP2K3(2), NFATC1(1), PRKACB(1), PRKAR1A(7) 1658294 13 9 12 1 0 0 3 1 9 0 0.356 0.0506 0.945 34 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 HLA-DRB1(3) 328912 3 3 3 1 0 0 2 1 0 0 0.742 0.0612 1.000 35 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1B(1), GLI2(2), GLI3(9), PRKACB(1), PRKAR1A(7), SHH(2), SMO(3), SUFU(1) 2248824 26 19 19 5 11 1 6 0 8 0 0.152 0.0684 1.000 36 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 GRM1(3), PLCB1(3), PPP1CA(2), PRKACB(1), PRKAR1A(7) 2185883 16 12 15 3 1 0 2 2 11 0 0.602 0.0787 1.000 37 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(1), CCR3(1), HLA-DRB1(3), IL3(1) 407360 6 5 6 2 0 0 4 2 0 0 0.680 0.0826 1.000 38 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(1), ALOX12(1), ALOX5(3), CYP4F2(1), CYP4F3(1), EPX(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PRDX1(1), PRDX2(2), PTGDS(1), PTGS1(1), PTGS2(1), TPO(22) 3909168 43 34 24 8 4 1 29 3 6 0 0.0910 0.0879 1.000 39 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), ECHS1(2), EHHADH(1), HADHA(1), SDS(1) 665589 6 5 6 0 1 0 2 1 2 0 0.235 0.0887 1.000 40 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 GLUD1(1), PRODH(4) 808834 5 5 4 0 1 1 0 3 0 0 0.252 0.0900 1.000 41 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 GALNS(1), GNS(2), HEXB(1), IDS(1), IDUA(14), LCT(1) 2869029 20 17 10 3 4 1 1 14 0 0 0.184 0.0907 1.000 42 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(1) 97560 1 1 1 0 0 0 0 0 1 0 0.717 0.0957 1.000 43 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CTH(1), GOT1(1), GOT2(2), LDHA(3) 910674 7 7 7 2 3 0 2 1 1 0 0.652 0.0987 1.000 44 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 EGFR(3), IGF1R(1), RB1(2), TEP1(2), TERT(1), TNKS(1), TP53(18) 3785860 28 21 28 6 5 1 7 1 13 1 0.388 0.102 1.000 45 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(1), GOT2(2) 356738 3 3 3 0 2 0 1 0 0 0 0.399 0.109 1.000 46 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 12 ADCY1(1), GNAS(5), PLCE1(2), PRKACB(1), PRKAR1A(7), RAP2B(1) 2071211 17 13 16 3 1 0 4 2 10 0 0.566 0.116 1.000 47 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(3), PAPSS2(1), SUOX(2) 815298 6 5 6 1 0 0 3 0 2 1 0.783 0.117 1.000 48 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(4), CREBBP(1), CTNNB1(14), DVL1(1), EP300(2), FZD1(6), HDAC1(1), LDB1(1), PITX2(3), TRRAP(1), WNT1(2) 4516441 36 27 26 5 3 0 12 7 14 0 0.341 0.118 1.000 49 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 PRKACB(1), PRKAR1A(7) 1746293 8 8 7 9 0 0 0 0 8 0 1.000 0.122 1.000 50 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(2), CHIA(2), CHIT1(3), CTBS(1), GNE(1), GNPDA1(1), HEXB(1), HK2(3), HK3(3), LHPP(2), MTMR1(1), MTMR2(1) 3943997 21 19 19 3 1 3 10 2 5 0 0.190 0.128 1.000 51 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(5), ATR(3), BRCA2(1), CHEK2(2), FANCF(1), MRE11A(1), RAD1(1), RAD17(1), RAD50(3), RAD51(1), RAD9A(1), TP53(18) 5893736 38 30 38 9 5 0 7 6 19 1 0.775 0.129 1.000 52 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA10(2), NDUFB5(2), NDUFB7(1), NDUFS2(1) 964591 7 6 7 0 1 0 4 0 2 0 0.215 0.131 1.000 53 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(2), MTMR1(1), MTMR2(1) 869921 4 4 3 1 0 3 0 0 1 0 0.705 0.143 1.000 54 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT3(3), FUT6(2) 707549 5 5 5 1 2 0 2 1 0 0 0.442 0.145 1.000 55 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(2), DPYD(2), DPYS(2), PANK2(15), PPCS(1) 1887197 22 20 9 5 1 0 17 2 2 0 0.451 0.151 1.000 56 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO2(1), ENO3(1), FARS2(1), GOT1(1), GOT2(2) 1118895 6 6 6 1 3 0 1 2 0 0 0.436 0.156 1.000 57 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ECHS1(2), HADH(1), HADHA(1), HADHB(1), HSD17B4(3), MECR(1) 1170442 9 7 9 0 0 0 5 2 2 0 0.138 0.162 1.000 58 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(1), FUCA1(4), FUCA2(1), HEXB(1), LCT(1), MANBA(2) 2305288 10 10 10 0 2 1 1 5 1 0 0.0845 0.166 1.000 59 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(2), TH(3) 826124 5 5 5 1 2 0 2 0 1 0 0.407 0.202 1.000 60 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 AOC3(1), EPX(1), ESCO2(1), GOT1(1), GOT2(2), MAOA(3), MIF(3), PNPLA3(2), TPO(22) 4637962 36 31 16 6 5 0 27 2 2 0 0.0794 0.202 1.000 61 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH6(1), ADH7(2), AOC3(1), DBH(2), DCT(1), GOT1(1), GOT2(2), HGD(1), MAOA(3), TH(3), TPO(22) 4370623 39 31 20 8 7 0 27 1 4 0 0.110 0.209 1.000 62 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(1), APC(4), BMPR1A(2), BMPR2(1), CHRD(2), CTNNB1(14), DVL1(1), FZD1(6), GATA4(1), MEF2C(2), NKX2-5(1), NOG(1), RFC1(1), TGFBR2(2), TGFBR3(4), WNT1(2) 4999122 45 28 35 9 2 1 15 11 16 0 0.605 0.216 1.000 63 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(1), FUCA1(4), FUCA2(1), GALNS(1), GNS(2), HEXB(1), IDS(1), IDUA(14), LCT(1), MAN2B1(1), MANBA(2) 4871048 29 22 19 4 5 3 1 19 1 0 0.113 0.230 1.000 64 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREBBP(1), EP300(2), PRKACB(1), PRKAR1A(7), RARA(1) 2810551 12 11 11 4 0 0 2 0 10 0 0.954 0.234 1.000 65 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ECHS1(2), EHHADH(1), HADHA(1), SDHB(1), SDS(1) 1058757 6 5 6 1 1 0 2 1 2 0 0.553 0.269 1.000 66 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(1), CCR3(1), HLA-DRB1(3) 726816 5 4 5 2 0 0 3 2 0 0 0.778 0.274 1.000 67 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 BDKRB2(1), KNG1(1), NOS3(4) 1377399 6 6 6 1 2 1 2 1 0 0 0.356 0.277 1.000 68 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS2(1), CTH(1), GOT1(1), GOT2(2), LDHA(3), SDS(1) 1717418 9 9 9 2 4 0 2 2 1 0 0.459 0.279 1.000 69 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), ECHS1(2), EHHADH(1), HADH(1), HADHA(1), HSD17B4(3), NTAN1(1), SIRT1(1) 1628304 11 8 11 0 0 0 6 2 3 0 0.0870 0.283 1.000 70 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(1), FSHR(1), GNAS(5), XPO1(1) 1311265 8 7 8 1 2 0 2 2 2 0 0.463 0.285 1.000 71 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(1), FUCA1(4), FUCA2(1), HEXB(1), LCT(1), MAN2B1(1), MANBA(2) 2846697 11 10 11 1 2 2 1 5 1 0 0.228 0.310 1.000 72 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 GOT1(1), GOT2(2) 635908 3 3 3 0 2 0 1 0 0 0 0.386 0.329 1.000 73 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ECHS1(2), EHHADH(1), HADHA(1), HADHB(1), SDS(1) 1143871 6 5 6 0 1 0 2 1 2 0 0.248 0.331 1.000 74 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(1) 158301 1 1 1 0 0 0 1 0 0 0 0.783 0.336 1.000 75 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(2), BCAT2(1), DPYD(2), DPYS(2), PANK2(15), PPCS(1), VNN1(1) 2359280 24 21 11 6 1 0 19 2 2 0 0.477 0.346 1.000 76 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 8 GABRA1(2), GABRA2(2), GABRA6(2), GPX1(1) 887334 7 6 7 2 0 0 6 1 0 0 0.678 0.351 1.000 77 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(1), GSS(1), NFKB1(1), NOX1(1), XDH(3) 1387484 7 6 7 0 0 0 5 1 1 0 0.190 0.352 1.000 78 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 HLA-DRB1(3), IL2(1) 544598 4 4 4 2 0 0 3 1 0 0 0.833 0.356 1.000 79 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), RB1(2) 888811 3 3 3 1 0 0 1 0 2 0 0.824 0.370 1.000 80 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT2(1), B3GALT5(1), FUT3(3) 988565 5 5 5 0 2 0 2 1 0 0 0.210 0.370 1.000 81 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1) 221925 1 1 1 0 0 0 1 0 0 0 0.772 0.371 1.000 82 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 GNE(1), GNPDA1(1), HEXB(1), HK2(3), HK3(3) 2332008 9 9 9 1 1 0 6 1 1 0 0.256 0.384 1.000 83 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(1) 228975 1 1 1 0 1 0 0 0 0 0 0.652 0.387 1.000 84 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(5), BMPR1B(1), CCND2(1), CEBPB(1), EGR1(2), FSHR(1), GJA4(1), MLH1(2), NCOR1(1), NR5A1(2), NRIP1(3), PGR(1), VDR(1) 4689063 22 16 22 3 2 2 8 1 9 0 0.296 0.396 1.000 85 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP5(1), ACP6(1), ACPP(1), FLAD1(1), LHPP(2), MTMR1(1), MTMR2(1) 2072410 8 8 7 2 0 3 2 2 1 0 0.611 0.399 1.000 86 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDK(1), CTH(1), MUT(1) 675049 3 3 3 0 0 0 2 0 1 0 0.608 0.400 1.000 87 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 FADS2(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1) 1460378 8 7 8 0 1 0 3 1 3 0 0.169 0.401 1.000 88 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLUD1(1), GLUD2(1) 610547 2 2 2 0 1 0 0 1 0 0 0.570 0.411 1.000 89 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(7), NDUFA12(1), NDUFB11(2) 575162 10 8 5 3 0 0 10 0 0 0 0.683 0.422 1.000 90 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(1) 202484 1 1 1 0 0 0 0 0 1 0 1.000 0.423 1.000 91 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(1), BMPR1A(2), BMPR1B(1), BMPR2(1) 845749 5 4 5 0 1 1 2 1 0 0 0.278 0.427 1.000 92 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ASPH(1), EP300(2), EPO(1), LDHA(3), NOS3(4), P4HB(1) 2302595 12 11 12 2 1 1 5 3 2 0 0.365 0.434 1.000 93 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 APAF1(1), DAXX(4) 1510615 5 5 5 1 0 1 0 0 4 0 0.715 0.434 1.000 94 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 EGR2(1), EGR3(1), MAP3K1(2), NFATC1(1), NFKB1(1), PLCG1(3), PPP3CB(1), PRKACB(1), PRKAR1A(7), VIP(1), VIPR2(1) 3785138 20 16 19 4 3 0 7 2 8 0 0.406 0.440 1.000 95 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 9 AKAP9(3), MAP2(2), PPP1CA(2), PRKACB(1) 2262487 8 8 8 1 0 0 3 1 4 0 0.649 0.442 1.000 96 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 HK2(3), HK3(3) 1432669 6 6 6 1 0 0 4 1 1 0 0.461 0.446 1.000 97 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ECHS1(2), HADHA(1) 739035 3 3 3 0 0 0 1 0 2 0 0.644 0.463 1.000 98 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 23 APC(4), CREBBP(1), CTNNB1(14), DVL1(1), FZD1(6), HDAC1(1), WIF1(1), WNT1(2) 4133071 30 26 20 6 0 0 10 7 13 0 0.753 0.466 1.000 99 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(1), CASP8(1), DFFA(1), GZMB(1), SCAP(4), SREBF2(2) 2577152 10 9 10 1 3 0 1 0 6 0 0.457 0.475 1.000 100 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(2), LEPR(2), PRKAA2(1), PRKAG2(3) 1943567 8 7 8 1 2 1 3 0 2 0 0.400 0.484 1.000 101 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 GRIA2(3) 521591 3 2 3 0 0 0 1 0 2 0 0.437 0.495 1.000 102 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 NDUFA1(1), SDHA(1), SDHB(1), SDHD(1) 882443 4 3 4 1 0 0 2 2 0 0 0.697 0.503 1.000 103 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCND2(1), CDKN2A(2), RB1(2), RBL1(1), TFDP1(1) 2148074 7 7 7 1 3 0 1 0 3 0 0.377 0.520 1.000 104 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(1), EIF2AK4(2), EIF2B5(1), PPP1CA(2) 1548603 6 5 6 0 0 0 1 1 4 0 0.621 0.524 1.000 105 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 CMA1(1), CPA3(1), CTSA(2), ENPEP(3), LNPEP(1), MME(3), NLN(3) 2873519 14 12 14 3 1 2 9 1 0 1 0.374 0.541 1.000 106 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CD3D(1), CREBBP(1), CSK(1), GNAS(5), GNB1(2), HLA-DRB1(3), LCK(1), PRKACB(1), PRKAR1A(7), ZAP70(1) 3182524 24 18 23 6 1 0 9 3 11 0 0.655 0.569 1.000 107 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CD3D(1), CREBBP(1), CSK(1), GNAS(5), GNB1(2), HLA-DRB1(3), LCK(1), PRKACB(1), PRKAR1A(7), ZAP70(1) 3182524 24 18 23 6 1 0 9 3 11 0 0.655 0.569 1.000 108 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(1), BCL2L1(2), CSF2RB(1), IGF1R(1), IL3(1), PIK3CA(1), PIK3R1(1), PRKACB(1), PRKAR1A(7) 2987110 16 14 15 4 2 0 3 2 9 0 0.707 0.593 1.000 109 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C9(1) 271437 1 1 1 1 0 0 1 0 0 0 0.947 0.595 1.000 110 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 CKM(2), LDHA(3) 1244675 5 5 5 1 1 0 2 2 0 0 0.563 0.604 1.000 111 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASDHPPT(1), KARS(1) 626882 2 2 2 1 1 0 1 0 0 0 0.863 0.614 1.000 112 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 LDLR(1), MBTPS1(2), SCAP(4), SREBF2(2) 1729468 9 6 9 1 3 0 2 0 4 0 0.424 0.617 1.000 113 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 PIK3CA(1), PIK3R1(1), PLCB1(3), PLCG1(3), VAV1(3) 1764475 11 9 11 3 5 0 3 2 1 0 0.597 0.619 1.000 114 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 APEX1(2), CREBBP(1), DFFA(1), GZMB(1) 1453793 5 5 5 1 2 0 2 1 0 0 0.507 0.619 1.000 115 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD3D(1), CD8A(1), IL3(1) 846177 3 3 3 0 0 1 2 0 0 0 0.400 0.627 1.000 116 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP14(2), MMP9(1), RECK(1), TIMP3(1) 1049960 5 4 5 2 2 0 1 0 2 0 0.843 0.633 1.000 117 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR2(1), GPR171(1), GPR34(1), GPR39(2), GPR68(1), GPR75(1) 1341959 7 6 7 2 1 0 5 1 0 0 0.511 0.634 1.000 118 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 CPS1(3), GLUD1(1), GOT1(1) 1058236 5 4 5 2 1 0 2 1 1 0 0.802 0.634 1.000 119 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(3) 1053317 3 3 3 0 0 0 1 2 0 0 0.475 0.647 1.000 120 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(1), B3GALNT1(1), B3GALT5(1), GBGT1(2), HEXB(1), ST3GAL1(1) 1453288 7 6 7 1 2 0 3 1 1 0 0.397 0.649 1.000 121 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), CASP8(1), FADD(2), TNFRSF1A(1) 1142801 5 5 5 2 1 1 1 0 2 0 0.876 0.665 1.000 122 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(2), IARS(1), LARS(1), LARS2(1), PDHB(1) 1347228 6 6 6 2 0 0 2 3 1 0 0.829 0.675 1.000 123 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(1), SNCAIP(1) 855228 2 2 2 1 0 0 2 0 0 0 0.877 0.678 1.000 124 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP8(1) 511888 1 1 1 1 0 0 0 0 1 0 1.000 0.682 1.000 125 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 RB1(2), TFDP1(1) 1149866 3 3 3 1 1 0 0 0 2 0 0.693 0.684 1.000 126 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 RB1(2), TFDP1(1) 1168917 3 3 3 1 1 0 0 0 2 0 0.685 0.691 1.000 127 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(1), ABCB11(1), ABCB4(2), ABCC1(1), ABCC3(2), GSTP1(1) 1977073 8 8 8 2 3 1 2 2 0 0 0.452 0.692 1.000 128 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT5(2), ST3GAL1(1) 1060998 3 3 3 0 1 0 0 2 0 0 0.493 0.692 1.000 129 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(5) 1864143 5 5 5 5 0 0 1 0 4 0 0.999 0.695 1.000 130 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(1) 426720 1 1 1 0 0 0 1 0 0 0 0.759 0.695 1.000 131 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 DFFA(1), GZMB(1), TOP2A(1) 1390656 3 3 3 1 2 0 1 0 0 0 0.782 0.697 1.000 132 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD3D(1) 442188 1 1 1 0 0 0 1 0 0 0 0.745 0.707 1.000 133 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 HGD(1) 305249 1 1 1 0 0 0 1 0 0 0 0.764 0.714 1.000 134 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST3GAL1(1) 768001 2 2 2 0 1 0 0 1 0 0 0.564 0.714 1.000 135 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPS(1), CHPT1(2), ENPP2(2), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLD2(1), PPAP2C(1) 3235717 14 10 14 1 2 0 8 2 2 0 0.102 0.723 1.000 136 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(1), FARSB(1), GOT1(1), GOT2(2) 1189492 5 5 5 2 2 0 1 1 1 0 0.816 0.731 1.000 137 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1) 526215 1 1 1 1 0 0 1 0 0 0 0.928 0.731 1.000 138 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(3), CHST11(1), CHST13(3), PAPSS2(1), SUOX(2) 1238650 10 8 9 4 0 0 4 3 2 1 0.886 0.735 1.000 139 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(1), BCL2L1(2), BCL2L11(1) 1552395 4 4 4 1 1 0 0 0 3 0 0.694 0.739 1.000 140 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 37 G6PD(2), GPX1(1), GPX7(1), GSS(1), GSTA2(1), GSTK1(1), GSTO2(1), GSTP1(1), GSTT2(2), MGST1(1), OPLAH(3) 3142966 15 12 14 3 4 1 4 1 5 0 0.480 0.739 1.000 141 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(1), CHAT(1), DBH(2), MAOA(3), SLC18A3(1), TH(3) 1999566 11 9 11 3 2 1 5 0 3 0 0.529 0.752 1.000 142 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(1), BCL2L1(2), CASP8(1), DFFA(1) 1830578 5 5 5 1 2 0 0 0 3 0 0.686 0.763 1.000 143 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(1), HEXB(1), LCT(1), ST3GAL1(1), ST6GALNAC3(1), ST6GALNAC5(1) 2221670 6 6 6 1 2 0 2 1 1 0 0.487 0.763 1.000 144 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH6(1), ADH7(2) 756040 3 3 3 5 1 0 0 1 1 0 0.999 0.765 1.000 145 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), CSAD(1) 803225 2 2 2 0 0 0 2 0 0 0 0.558 0.765 1.000 146 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 OXCT1(1) 459287 1 1 1 0 0 0 0 1 0 0 0.737 0.766 1.000 147 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(1), GBGT1(2), HEXB(1), ST3GAL1(1) 1373769 5 4 5 1 1 0 2 1 1 0 0.618 0.769 1.000 148 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 RB1(2), TFDP1(1) 1138640 3 3 3 2 1 0 0 0 2 0 0.889 0.769 1.000 149 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(2), EGFR(3), TF(1) 1724137 6 6 6 2 2 0 2 2 0 0 0.701 0.778 1.000 150 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP5(1), ACPP(1), FLAD1(1) 1333133 3 3 3 1 0 0 2 1 0 0 0.762 0.782 1.000 151 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 EGR1(2), MAPK1(1), NGFR(2) 1149786 5 5 5 1 3 0 1 1 0 0 0.386 0.786 1.000 152 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDHPPT(1), KARS(1) 919051 2 2 2 1 1 0 1 0 0 0 0.858 0.790 1.000 153 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 GRIN1(1), GRIN2B(2), GRIN2C(2), GRIN2D(1), NOS1(2), PPP3CB(1), PRKACB(1), PRKAR1A(7) 3563730 17 14 16 9 4 0 4 1 8 0 0.965 0.790 1.000 154 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ALDH6A1(1), BCAT1(2), BCAT2(1), ECHS1(2), EHHADH(1), HADH(1), HADHA(1), HADHB(1), HMGCS2(1), HSD17B4(3), MCCC1(2), MUT(1), OXCT1(1), PCCA(1) 5937275 19 16 19 0 0 0 10 6 3 0 0.0118 0.796 1.000 155 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(1), SHMT2(1) 599187 2 2 2 0 1 0 1 0 0 0 0.481 0.799 1.000 156 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 PTGS1(1), PTGS2(1) 716546 2 2 2 2 0 0 1 0 1 0 0.980 0.802 1.000 157 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ALDH6A1(1), BCAT1(2), ECHS1(2), EHHADH(1), HADHA(1), HADHB(1), MCCC1(2), MUT(1), OXCT1(1), PCCA(1), SDS(1) 4918177 14 13 14 1 1 0 5 5 3 0 0.124 0.802 1.000 158 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(1), CYP11B1(1), CYP11B2(1), CYP17A1(1), CYP21A2(1), HSD11B1(1) 1324127 7 7 7 8 1 0 4 0 2 0 0.997 0.804 1.000 159 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(1), CYP11B1(1), CYP11B2(1), CYP17A1(1), CYP21A2(1), HSD11B1(1) 1324127 7 7 7 8 1 0 4 0 2 0 0.997 0.804 1.000 160 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 SHH(2), XPO1(1) 1175229 3 3 3 1 1 0 2 0 0 0 0.725 0.804 1.000 161 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG3(1), BECN1(1), GABARAPL1(1), IFNA8(1), PIK3C3(1), PRKAA2(1), ULK1(1), ULK2(1), ULK3(1) 2897090 9 8 9 1 0 0 4 1 4 0 0.527 0.813 1.000 162 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 GOT1(1), GOT2(2), GPT2(2), MDH2(1), PGK2(3), RPIA(1), TKTL2(3) 2762154 13 9 12 4 3 2 5 1 2 0 0.590 0.821 1.000 163 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 F13A1(1), PLAT(1), PLG(1), SERPINB2(1), SERPINE1(1) 1824174 5 4 5 1 1 1 1 1 1 0 0.562 0.822 1.000 164 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SRP72(3) 1015653 3 3 3 0 1 0 2 0 0 0 0.464 0.827 1.000 165 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 RAB6A(1) 585537 1 1 1 0 0 0 0 1 0 0 0.794 0.827 1.000 166 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 KEAP1(2), MAPK1(1) 1256548 3 3 3 1 1 0 1 1 0 0 0.686 0.827 1.000 167 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD3D(1), CTLA4(2), HLA-DRB1(3), IL2(1), ITK(1), LCK(1), PIK3CA(1), PIK3R1(1), PTPN11(1) 1734581 12 12 12 4 0 0 6 5 1 0 0.757 0.831 1.000 168 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 DCN(2) 491541 2 1 2 1 0 0 2 0 0 0 0.813 0.833 1.000 169 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6V0A1(2), ATP6V0A4(1), ATP6V0C(1), ATP6V1A(1), FDXR(2) 2185409 7 7 7 2 1 0 4 2 0 0 0.603 0.837 1.000 170 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ECHS1(2), EHHADH(1), HADHA(1), SDS(1) 1664821 5 4 5 0 1 0 2 0 2 0 0.284 0.845 1.000 171 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 IL3(1), ITGAX(1), TLR2(2), TLR4(3), TLR7(1), TLR9(2) 2528489 10 8 10 2 0 0 8 1 1 0 0.399 0.850 1.000 172 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNB1(2), HTR2C(1), PLCB1(3), TUB(1) 966641 7 7 7 3 2 0 4 1 0 0 0.759 0.851 1.000 173 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACSL1(3), ACSL3(2), EHHADH(1), HADHA(1) 2279180 7 6 7 2 1 1 3 0 2 0 0.686 0.852 1.000 174 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 FUT3(3), FUT4(1), FUT6(2), GCNT2(1) 2185668 7 7 7 2 3 0 2 2 0 0 0.575 0.853 1.000 175 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 UGP2(1), UGT1A3(1), UGT1A5(2), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B15(2), UGT2B28(1) 3646659 14 10 13 2 1 0 11 2 0 0 0.268 0.855 1.000 176 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT10(1), GALNT3(2), GALNT4(1), GALNT8(2), ST3GAL1(1) 2009424 7 5 7 1 0 0 2 2 3 0 0.593 0.860 1.000 177 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(2) 1063189 2 2 2 1 0 0 1 1 0 0 0.863 0.861 1.000 178 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(1), MTFMT(4), MTHFD1(1), MTHFD1L(1), MTHFR(1), MTR(1), SHMT2(1) 2619899 10 10 8 3 2 0 1 7 0 0 0.585 0.861 1.000 179 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 CASP8(1), FADD(2), MAP3K1(2), MAPK1(1), NFKB1(1), NSMAF(3), TNFRSF1A(1) 2776255 11 11 9 3 2 1 3 4 1 0 0.630 0.862 1.000 180 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(2), AOC3(1), CHDH(6), CHKB(1), CTH(1), DAO(1), GARS(35), GCAT(2), MAOA(3), PEMT(1), PIPOX(1), SARDH(1), SDS(1), SHMT2(1) 5995146 57 47 19 13 5 1 37 10 4 0 0.166 0.864 1.000 181 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(1), CASP8(1), GZMB(1) 1721575 3 3 3 1 1 0 0 0 2 0 0.822 0.867 1.000 182 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 ADSS(1), AGXT(2), CAD(1), DDO(1), GOT1(1), GOT2(2), GPT2(2), PC(1) 3608683 11 10 10 2 3 2 2 2 2 0 0.392 0.868 1.000 183 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 CAPN2(3), CAPNS1(1), CXCR3(2), EGFR(3), MAPK1(1), MYLK(2), PRKACB(1), PRKAR1A(7), TLN1(2) 4583036 22 18 21 9 5 0 6 2 9 0 0.864 0.869 1.000 184 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ANXA1(1), GNAS(5), GNB1(2), NFKB1(1), NOS3(4), PIK3CA(1), PIK3R1(1) 2522425 15 13 15 4 2 1 7 3 2 0 0.629 0.869 1.000 185 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B4GALT7(1), HS3ST2(3), HS3ST3A1(2), XYLT1(1) 936848 7 4 7 3 2 1 4 0 0 0 0.681 0.872 1.000 186 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B4GALT7(1), HS3ST2(3), HS3ST3A1(2), XYLT1(1) 936848 7 4 7 3 2 1 4 0 0 0 0.681 0.872 1.000 187 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 UGP2(1) 683415 1 1 1 0 0 0 1 0 0 0 0.780 0.874 1.000 188 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CYP11B2(1), CYP17A1(1), HSD11B1(1) 943234 3 3 3 3 0 0 2 0 1 0 0.980 0.877 1.000 189 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 PFKL(2), PGAM1(1) 1259150 3 3 3 1 1 1 0 1 0 0 0.699 0.878 1.000 190 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 HMGCS2(1), OXCT1(1) 1013102 2 2 2 0 0 0 1 1 0 0 0.599 0.884 1.000 191 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 22 FADD(2), IRAK1(2), MAP3K1(2), NFKB1(1), TLR4(3), TNFRSF1A(1) 3374559 11 10 10 3 2 1 6 2 0 0 0.563 0.888 1.000 192 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(1), ALPP(1), ALPPL2(8), ASCC3(1), ATP13A2(1), DDX18(2), DDX4(2), DDX50(2), EP400(4), ERCC2(19), ERCC3(1), FPGS(14), MOV10L1(1), PTS(1), RAD54B(1), RUVBL2(1), SETX(2), SMARCA2(4), SMARCA5(1), SPR(1) 8571596 68 44 31 13 21 10 10 18 9 0 0.0730 0.889 1.000 193 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(1), AFMID(1), CS(1), GRHPR(1), HAO1(1), MDH2(1), MTHFD1(1), MTHFD1L(1) 1823536 8 6 8 2 1 0 5 2 0 0 0.568 0.889 1.000 194 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(1), PLCB1(3) 1137637 4 3 4 2 1 0 2 1 0 0 0.799 0.893 1.000 195 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 G6PD(2), GPX1(1), GSS(1), GSTA2(1), GSTO2(1), GSTP1(1), GSTT2(2), MGST1(1) 2559485 10 10 10 3 2 1 2 1 4 0 0.793 0.894 1.000 196 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(1), CHAT(1), PEMT(1), SLC18A3(1) 955793 4 2 4 2 0 1 2 1 0 0 0.845 0.900 1.000 197 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 13 DUSP1(1), IKBKAP(2), MAP3K1(2), NFKB1(1) 2544408 6 6 6 0 1 0 4 0 1 0 0.201 0.901 1.000 198 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(1), HLA-A(4), LAT(1), PIK3CA(1), PIK3R1(1), PTPN6(1), SYK(1), VAV1(3) 2591379 13 10 12 3 3 0 2 3 5 0 0.671 0.901 1.000 199 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 GCNT2(1) 860306 1 1 1 1 1 0 0 0 0 0 0.940 0.903 1.000 200 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 MAP2K3(2), MAP3K1(2), MAPK1(1), NFKB1(1), PIK3CA(1), PIK3R1(1), RB1(2) 2670656 10 9 10 3 1 0 4 3 2 0 0.673 0.906 1.000 201 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 THBS1(1) 969294 1 1 1 0 0 0 0 1 0 0 0.808 0.906 1.000 202 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGFR(3), ERBB3(1) 1392874 4 4 4 2 2 0 2 0 0 0 0.837 0.907 1.000 203 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(1), CS(1), GRHPR(1), HAO1(1), MDH2(1), MTHFD1(1), MTHFD1L(1) 1738418 7 6 7 2 1 0 4 2 0 0 0.639 0.907 1.000 204 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(1), FH(1), MDH2(1), SDHB(1) 1213540 4 3 4 2 0 0 3 1 0 0 0.871 0.919 1.000 205 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 UGT1A3(1), UGT1A5(2), UGT2B15(2) 2347962 5 5 5 0 1 0 2 2 0 0 0.254 0.922 1.000 206 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(1), GNAS(5), GNB1(2), NFATC1(1), PLCG1(3), PPP3CB(1), PRKACB(1), PRKAR1A(7) 4784170 21 17 20 6 3 0 6 2 10 0 0.728 0.925 1.000 207 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(2), POLD2(1), POLE(3), POLG(1), POLQ(1) 2308300 8 7 7 2 1 1 3 2 1 0 0.645 0.925 1.000 208 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 18 DUSP1(1), IKBKAP(2), MAP3K1(2), NFKB1(1), TANK(1) 3129307 7 7 7 1 1 0 5 0 1 0 0.389 0.927 1.000 209 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 JAK1(1), JAK2(2) 1102806 3 2 3 2 0 0 1 2 0 0 0.921 0.929 1.000 210 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CDKN2A(2) 1219123 2 2 2 1 0 0 1 0 1 0 0.922 0.930 1.000 211 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(5), NRG2(2), NRG3(2) 1228071 9 6 8 4 2 0 5 2 0 0 0.794 0.932 1.000 212 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMB1(2), PSMB3(1), PSMB5(1), PSMC2(2), PSMD6(1) 2174857 7 4 7 1 1 0 3 2 1 0 0.509 0.933 1.000 213 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 LRP8(1), RELN(7) 1894701 8 7 8 3 0 0 5 3 0 0 0.755 0.935 1.000 214 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ARPC2(1) 1121521 1 1 1 3 0 0 0 0 1 0 1.000 0.937 1.000 215 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CTH(1), MARS(1), MARS2(1), PAPSS2(1), SCLY(1) 1717294 5 4 5 5 1 0 1 1 2 0 0.995 0.938 1.000 216 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 GAB1(1), MAP3K1(2), MAP3K12(1), MAP3K13(1), MAP3K3(1), MAP3K4(1), MAPK7(2), MYEF2(1), NR2C2(1), PAPPA(5), TP53(18) 6861642 34 22 33 9 5 1 14 2 11 1 0.598 0.939 1.000 217 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CHPT1(2), LCMT1(1), PCYT1B(1), WBSCR22(1) 1926195 5 5 5 2 0 1 3 1 0 0 0.723 0.943 1.000 218 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 CEBPB(1), CLDN5(3), CRY2(1), GFRA1(2), GSTP1(1), HSPA8(1), IDI1(5), KLF9(1), NCKAP1(1), NCOA4(2), PER1(1), UGP2(1), VAPA(1), ZFR(1) 5039485 22 17 19 4 3 2 12 4 1 0 0.258 0.943 1.000 219 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(2), GATA1(1) 1125562 3 3 3 2 1 0 1 1 0 0 0.899 0.946 1.000 220 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 HDAC9(2), MEF2C(2) 1169349 4 3 4 2 1 0 1 1 1 0 0.885 0.947 1.000 221 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC3(1) 809070 1 1 1 1 1 0 0 0 0 0 0.908 0.948 1.000 222 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOSL2(1), IFNAR2(1), NFKB1(1), TNFRSF11A(1), TNFSF11(1) 1505771 5 5 5 2 1 0 4 0 0 0 0.757 0.950 1.000 223 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ACACA(2), ACACB(4), ACSS2(1), ALDH6A1(1), ECHS1(2), EHHADH(1), HADHA(1), LDHA(3), MUT(1), PCCA(1) 5365060 17 13 17 3 2 0 10 2 3 0 0.347 0.951 1.000 224 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(2), ATP6V0A4(1), ATP6V0C(1), ATP6V1A(1) 2056943 5 5 5 2 1 0 3 1 0 0 0.741 0.951 1.000 225 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(2), ATP6V0A4(1), ATP6V0C(1), ATP6V1A(1) 2056943 5 5 5 2 1 0 3 1 0 0 0.741 0.951 1.000 226 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(2), ATP6V0A4(1), ATP6V0C(1), ATP6V1A(1) 2056943 5 5 5 2 1 0 3 1 0 0 0.741 0.951 1.000 227 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 SHMT2(1) 793973 1 1 1 0 1 0 0 0 0 0 0.673 0.951 1.000 228 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(2), BLVRA(1), CP(1), EPRS(3), UGT1A3(1), UGT1A5(2), UGT2B15(2) 3686394 12 9 12 3 2 0 4 5 1 0 0.511 0.952 1.000 229 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3D(1), IL2(1), TGFBR2(2), TGFBR3(4), TOB2(1) 1462586 9 7 9 6 1 0 5 1 2 0 0.975 0.952 1.000 230 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(1), ABCC2(2), BCHE(2), UGT1A3(1), UGT1A5(2) 3074663 8 7 8 0 1 0 5 2 0 0 0.104 0.955 1.000 231 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 MAPK1(1), NFKB1(1), PLCB1(3) 2099992 5 4 5 1 1 0 2 2 0 0 0.511 0.955 1.000 232 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 MAPK1(1), NFKB1(1), PIK3CA(1), PIK3R1(1), RB1(2), TFDP1(1) 2757893 7 7 7 2 1 0 2 2 2 0 0.637 0.956 1.000 233 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMB1(2), PSMB3(1), PSMB5(1), PSMB9(1) 1199407 5 2 5 1 1 0 4 0 0 0 0.577 0.956 1.000 234 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(2), GABBR1(2), GPRC5B(1), GPRC5D(1), GRM1(3), GRM3(3), GRM4(1), GRM5(1), GRM8(4) 2844263 18 7 18 3 1 0 12 3 2 0 0.150 0.959 1.000 235 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 EPRS(3), FARS2(1), GARS(35), IARS(1), KARS(1), LARS(1), LARS2(1), MARS(1), MARS2(1), QARS(1), WARS2(1) 4302753 47 40 15 10 3 1 35 6 2 0 0.258 0.960 1.000 236 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ALDH5A1(1), CAD(1), CPS1(3), EPRS(3), GLUD1(1), GMPS(1), GOT1(1), GOT2(2), GPT2(2), GSS(1), NADSYN1(2), QARS(1) 4541645 19 13 19 4 2 3 5 4 5 0 0.451 0.963 1.000 237 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 16 CREBBP(1), EP300(2), FADD(2), NFKB1(1), TNFRSF1A(1) 3073962 7 7 7 2 1 1 4 0 1 0 0.704 0.965 1.000 238 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 WDR1(2) 1502161 2 2 2 2 0 0 0 1 1 0 0.981 0.967 1.000 239 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR2B(2), POLR2H(1), POLRMT(5) 1849011 8 8 5 3 1 4 2 0 1 0 0.766 0.969 1.000 240 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(3), PRKACB(1) 1370134 4 3 4 2 0 0 2 0 2 0 0.930 0.970 1.000 241 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 CTSD(1), ESR1(1), TUBA8(2) 1540273 4 4 4 2 2 0 1 1 0 0 0.753 0.970 1.000 242 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(1), JAK1(1), JAK2(2), TYK2(2) 1440563 7 6 7 3 0 1 2 2 2 0 0.846 0.971 1.000 243 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(1), JAK1(1), JAK2(2), TYK2(2) 1440563 7 6 7 3 0 1 2 2 2 0 0.846 0.971 1.000 244 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 32 CD14(1), IRAK1(2), MAP2K3(2), MAP3K1(2), NFKB1(1), PPARA(1), TLR2(2), TLR4(3), TLR6(1), TLR7(1), TLR9(2) 5022047 18 15 17 4 1 1 9 5 2 0 0.485 0.973 1.000 245 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(1), JAK2(2), JAK3(3), MAPK1(1), TYK2(2) 1660174 9 6 9 3 1 0 2 4 2 0 0.746 0.973 1.000 246 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR2(1), JAK1(1), TYK2(2) 1482978 4 4 4 2 1 0 1 0 2 0 0.848 0.974 1.000 247 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD3D(1), CD8A(1), ICAM1(1), ITGAL(1) 1447271 4 4 4 2 1 1 2 0 0 0 0.782 0.975 1.000 248 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CRY2(1), PER1(1) 1181670 2 2 2 0 1 0 1 0 0 0 0.563 0.976 1.000 249 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 HK2(3), HK3(3) 1643856 6 6 6 3 0 0 4 1 1 0 0.852 0.977 1.000 250 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(1), PGAP1(1), PIGG(2), PIGO(1), PIGU(2), PIGZ(1) 3399862 9 5 9 2 0 1 4 1 3 0 0.559 0.977 1.000 251 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 31 APC(4), CTNNB1(14), DACT1(2), DKK1(1), DKK2(1), DVL1(1), LRP1(6), NKD1(1), NKD2(1), PIN1(1), PTPRA(1), WIF1(1) 5638790 34 25 29 8 6 0 12 10 6 0 0.476 0.977 1.000 252 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C6(1), C7(1), C9(3) 1728980 5 5 5 3 0 0 3 1 1 0 0.900 0.977 1.000 253 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(1), JAK1(1) 1655844 2 2 2 1 1 0 1 0 0 0 0.781 0.977 1.000 254 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 CAPNS1(1) 1332097 1 1 1 2 0 0 0 0 1 0 0.974 0.977 1.000 255 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 JAK1(1), JAK2(2), PTPRU(1) 1558492 4 3 4 2 0 0 2 2 0 0 0.861 0.978 1.000 256 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 KHK(2), LCT(1), PYGL(1) 1889952 4 4 4 2 2 0 1 1 0 0 0.825 0.978 1.000 257 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 ICAM1(1), ITGA4(1), ITGAL(1), SELE(1) 1686558 4 4 4 3 1 0 1 1 0 1 0.943 0.980 1.000 258 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 DLL1(1), NOTCH1(4) 1349431 5 5 4 3 1 1 2 0 1 0 0.900 0.980 1.000 259 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 APOBEC3F(1) 984812 1 1 1 0 0 0 1 0 0 0 0.764 0.983 1.000 260 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(1), CR2(2), HLA-DRB1(3), ICAM1(1), ITGAL(1) 2075799 8 8 8 5 2 0 3 1 2 0 0.940 0.984 1.000 261 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(1), ATP6V0C(1), MTHFD1(1), MTHFD1L(1), MTHFR(1), MTR(1), SHMT2(1) 2440169 7 7 7 3 2 0 2 3 0 0 0.746 0.984 1.000 262 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 DHRS3(1), PON1(1) 1225164 2 2 2 5 0 0 0 1 1 0 1.000 0.984 1.000 263 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(1), EP300(2), ESR1(1), MAPK1(1), PELP1(1) 2057460 6 6 6 3 0 0 2 2 2 0 0.943 0.985 1.000 264 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(2), ARSD(2), GAL3ST1(1), GALC(1), LCT(1), PPAP2C(1), SPTLC1(1), SPTLC2(1) 3318796 10 9 10 3 1 0 8 0 1 0 0.537 0.987 1.000 265 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 IL4R(1), JAK1(1), JAK3(3), STAT6(1) 2032611 6 5 6 2 1 1 2 2 0 0 0.704 0.987 1.000 266 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(1), HLA-DRB1(3), LCK(1), ZAP70(1) 1249592 6 6 6 3 0 0 4 1 1 0 0.832 0.988 1.000 267 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(1), CASP8(1), DFFA(1), GZMB(1), LMNB1(1), LMNB2(2) 2637896 7 6 7 3 4 0 0 0 3 0 0.853 0.988 1.000 268 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ARPC2(1), PDGFRA(1), PIK3CA(1), PIK3R1(1) 1831299 4 4 4 6 0 0 1 2 1 0 0.999 0.990 1.000 269 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(1), IL3(1), JAK2(2), PTPN6(1), STAT5B(1) 2431806 6 4 6 2 0 0 2 2 2 0 0.797 0.990 1.000 270 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6R(1), JAK1(1), JAK2(2), JAK3(3), PTPRU(1) 2121410 8 7 8 3 1 0 4 3 0 0 0.731 0.990 1.000 271 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH6(1), ADH7(2) 1821558 3 3 3 6 1 0 0 1 1 0 1.000 0.991 1.000 272 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 JAK1(1), PTPRU(1), TYK2(2) 1718758 4 3 4 2 0 0 2 0 2 0 0.861 0.991 1.000 273 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 BCL2L1(2), H2AFX(1), NFKB1(1), PIK3CA(1), PIK3R1(1) 2695438 6 5 6 2 1 0 3 1 1 0 0.766 0.991 1.000 274 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 BST1(2), NADSYN1(2), NMNAT3(1), NNT(1), NT5C1A(1), NT5C1B(2), NT5E(1), NT5M(1) 2925904 11 9 10 5 1 2 5 0 3 0 0.851 0.992 1.000 275 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP8(1), DAXX(4), DFFA(1), FADD(2), LMNB1(1), LMNB2(2), MAP3K1(2), PRKDC(3), PTPN13(2), RB1(2), RIPK2(1), SPTAN1(3) 5837396 24 16 24 5 7 2 4 2 9 0 0.440 0.992 1.000 276 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F5(2), PROC(1), PROS1(1), TFPI(1) 2253243 5 5 5 2 1 0 2 2 0 0 0.736 0.992 1.000 277 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ELOVL5(2), FADS2(1), FASN(3), HADHA(1) 2114071 7 6 7 5 0 0 2 3 2 0 0.992 0.992 1.000 278 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CXCR4(1), PLCG1(3) 1850128 4 4 4 3 2 0 1 0 1 0 0.929 0.992 1.000 279 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AOC3(1), DDHD1(3), ESCO2(1), PNPLA3(2) 3395984 7 6 6 2 3 0 1 3 0 0 0.584 0.993 1.000 280 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMKK2(1) 1640507 1 1 1 1 0 0 1 0 0 0 0.942 0.994 1.000 281 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 EPO(1), GRIN1(1), JAK2(2), NFKB1(1) 1819764 5 3 5 2 0 0 3 2 0 0 0.808 0.994 1.000 282 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 ST3GAL1(1) 1664404 1 1 1 1 0 0 0 1 0 0 0.955 0.994 1.000 283 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 NFKB1(1), PIK3CA(1), PIK3R1(1) 1939192 3 3 3 2 0 0 2 1 0 0 0.919 0.995 1.000 284 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CRY2(1), NR1D1(1), PER1(1), PER3(3) 2349770 6 4 6 2 1 0 3 0 2 0 0.751 0.995 1.000 285 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 GOT1(1), GOT2(2), GPT2(2), MDH2(1), ME2(1), RPIA(1) 2476032 8 7 8 4 2 1 3 0 2 0 0.863 0.995 1.000 286 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 BPNT1(3), MAPK1(1), PIK3CA(1) 2747034 5 4 5 2 0 0 1 2 1 1 0.934 0.995 1.000 287 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 EIF2B5(1), IGF1R(1), PIK3CA(1), PIK3R1(1) 2707236 4 4 4 2 1 0 2 1 0 0 0.848 0.995 1.000 288 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 NGFR(2), NTRK1(1), PIK3CA(1) 2284819 4 4 4 2 2 0 1 1 0 0 0.815 0.995 1.000 289 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD3D(1), CXCR3(2), JAK2(2), TYK2(2) 2068886 7 3 7 4 1 0 1 3 2 0 0.926 0.996 1.000 290 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 CA3(1), CPS1(3), CTH(1), GLUD1(1) 2577614 6 4 6 5 1 0 2 1 2 0 0.982 0.996 1.000 291 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 ICAM1(1), ITGA4(1), ITGAL(1), ITGAM(2), SELE(1), SELP(2) 2238692 8 6 8 4 1 0 4 2 0 1 0.878 0.996 1.000 292 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 GOSR2(2), STX18(1), STX19(1), STX7(1), TSNARE1(2), VAMP1(1), VTI1B(1) 2337003 9 9 9 4 1 0 2 4 2 0 0.858 0.996 1.000 293 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 BFAR(1), BRAF(1), MAPK1(1) 1577798 3 3 3 2 0 0 1 2 0 0 0.930 0.996 1.000 294 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD3D(1), ICAM1(1), ITGAL(1) 1529295 3 3 3 2 1 0 2 0 0 0 0.865 0.996 1.000 295 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 ICAM1(1), ITGAL(1), ITGAM(2), SELE(1) 1490071 5 5 5 3 1 0 2 2 0 0 0.892 0.997 1.000 296 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ARPC2(1), NCKAP1(1), NTRK1(1), WASF2(1) 2089405 4 4 4 4 0 0 2 1 1 0 0.987 0.997 1.000 297 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMB1(2), PSMB3(1), PSMB5(1), RPN2(2), UBE3A(1) 1798016 7 2 7 2 2 0 5 0 0 0 0.638 0.997 1.000 298 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1S(1), C2(1), C6(1), C7(1), C9(3) 2433350 7 7 7 4 1 0 3 2 1 0 0.876 0.997 1.000 299 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 JAK1(1), JAK2(2), JAK3(3), STAT5B(1), TYK2(2) 2588447 9 7 9 4 1 0 2 3 3 0 0.878 0.997 1.000 300 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(1), ALOX12(1), ALOX12B(1), ALOX5(3), CYP2B6(3), CYP2C9(1), CYP2J2(1), CYP2U1(2), CYP4A22(4), CYP4F2(1), CYP4F3(1), GPX1(1), GPX7(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PTGDS(1), PTGS1(1), PTGS2(1) 5499927 31 17 31 9 2 3 14 5 7 0 0.600 0.998 1.000 301 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 BAG4(1), CASP8(1), DFFA(1), FADD(2), LMNB1(1), LMNB2(2), MAP3K1(2), PRKDC(3), RB1(2), SPTAN1(3), TNFRSF1A(1) 5448544 19 15 19 5 7 1 4 0 7 0 0.559 0.998 1.000 302 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ACACA(2), ALDH6A1(1), ECHS1(2), EHHADH(1), HADHA(1), LDHA(3), MUT(1), PCCA(1), SDS(1) 4467642 13 11 13 4 3 0 7 1 2 0 0.651 0.998 1.000 303 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 52 CREBBP(1), GATA4(1), LIF(1), MAPK1(1), MEF2C(2), MYH2(2), NFATC1(1), NKX2-5(1), PIK3CA(1), PIK3R1(1), PPP3CB(1), PRKACB(1), PRKAR1A(7) 6856660 21 13 20 6 0 1 7 5 8 0 0.757 0.998 1.000 304 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(2), ACACB(4), FASN(3), OLAH(1) 2259396 10 8 10 5 1 0 5 3 1 0 0.916 0.998 1.000 305 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 CA3(1), CPS1(3), CTH(1), GLUD1(1), GLUD2(1) 2878700 7 5 7 6 2 0 2 1 2 0 0.987 0.998 1.000 306 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(1), EP300(2), JAK1(1), JAK3(3), LCK(1), PIK3CA(1), PIK3R1(1), STAT5B(1) 3816725 11 10 11 3 1 0 5 2 3 0 0.697 0.998 1.000 307 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), F2RL1(1), MAPK1(1), MAPK7(2), MYEF2(1), PLD2(1), TEC(1), VAV1(3) 3801255 11 9 10 3 2 0 6 1 2 0 0.550 0.999 1.000 308 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(4), B4GALT5(2), C1GALT1(1), GALNT10(1), GALNT12(2), GALNT14(1), GALNT3(2), GALNT4(1), GALNT5(1), GALNT8(2), OGT(1), ST3GAL1(1), ST6GALNAC1(1) 4428512 20 14 17 6 3 1 5 4 7 0 0.797 0.999 1.000 309 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(1), ALOX5(3), PTGDS(1), PTGS1(1), PTGS2(1) 2174199 7 7 7 5 0 1 3 2 1 0 0.976 0.999 1.000 310 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(4), CDH1(1), CREBBP(1), EP300(2), SKIL(1), TGFBR2(2) 3488080 11 10 11 6 0 0 6 2 3 0 0.983 0.999 1.000 311 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 NADSYN1(2), NNT(1), NT5E(1), NT5M(1) 1987836 5 4 5 5 1 2 1 0 1 0 0.988 0.999 1.000 312 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 CTH(1), DNMT3B(1), MARS(1), MARS2(1), MTR(1) 2411145 5 5 5 7 1 1 0 2 1 0 0.999 0.999 1.000 313 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGFR(3), MAP3K1(2), NCOR2(4), RARA(1), THRA(1) 2392065 11 9 11 5 3 0 4 3 1 0 0.873 0.999 1.000 314 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 ITPR1(2), ITPR2(4), ITPR3(5), TF(1) 4984271 12 10 12 3 2 0 5 5 0 0 0.483 0.999 1.000 315 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 MUSK(3), PIK3CA(1), PIK3R1(1), TERT(1) 2308521 6 6 6 3 1 1 2 2 0 0 0.868 0.999 1.000 316 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3D(1), CXCR3(2), ETV5(2), IL18R1(2), JAK2(2), TYK2(2) 2571835 11 7 11 6 2 0 3 4 2 0 0.929 0.999 1.000 317 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1S(1), C2(1), C6(1), C7(1), C8B(1), C9(3) 2877130 8 8 8 4 2 0 3 2 1 0 0.813 0.999 1.000 318 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(1), CS(1), DLST(1), FH(1), IDH3G(1), MDH2(1), PC(1), PCK1(1), SDHA(1), SDHB(1) 2825244 10 6 10 4 0 1 7 2 0 0 0.756 0.999 1.000 319 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 BDKRB2(1), FLT4(6), KDR(1), NOS3(4), PDE2A(1), PDE3A(2), PDE3B(1), PRKACB(1), PRKAR1A(7), PRKG2(2), RYR2(12) 5792409 38 23 37 10 8 4 10 6 10 0 0.417 0.999 1.000 320 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS3(1), ESCO2(1), PNPLA3(2) 2189249 4 3 4 3 0 0 1 2 1 0 0.959 0.999 1.000 321 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 EPO(1), JAK2(2), PLCG1(3), PTPN6(1), STAT5B(1) 2991336 8 6 8 4 2 0 2 2 2 0 0.892 0.999 1.000 322 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CTH(1), LCMT1(1), MARS(1), MARS2(1), PAPSS2(1), SCLY(1), WBSCR22(1) 3431645 7 6 7 7 1 1 2 1 2 0 0.995 0.999 1.000 323 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 DHRS3(1), LCMT1(1), WBSCR22(1) 2048454 3 3 3 5 0 1 1 0 1 0 0.995 0.999 1.000 324 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR3(1), CCR4(1), CXCR3(2), CXCR4(1), IL18R1(2), IL2(1), IL4R(1) 2769860 9 9 9 8 2 1 3 2 1 0 0.990 0.999 1.000 325 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1S(1), C2(1), C6(1), C7(1), C9(3) 2970998 7 7 7 5 1 0 3 2 1 0 0.929 0.999 1.000 326 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 DHRS3(1), ECHS1(2), EHHADH(1), ESCO2(1), HADHA(1), PNPLA3(2) 3487588 8 6 8 3 0 0 3 2 3 0 0.835 0.999 1.000 327 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(1), POLR1C(2), POLR2B(2), POLR2H(1) 3178546 6 5 6 2 1 0 4 0 1 0 0.775 0.999 1.000 328 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACO1(1), ACSS2(1), FH(1), MDH2(1) 1809270 4 2 4 2 0 0 4 0 0 0 0.854 1.000 1.000 329 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(2), EPN1(1), PICALM(1), PPP3CB(1), SYNJ1(1) 3108675 6 6 6 3 0 0 6 0 0 0 0.844 1.000 1.000 330 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX5(3), CYP2C9(1), CYP2J2(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1) 3318866 12 8 12 9 1 1 6 2 2 0 0.985 1.000 1.000 331 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(1), ALDH5A1(1), ECHS1(2), EHHADH(1), HADHA(1), OXCT1(1), PDHB(1), SDHB(1), SDS(1) 3516086 10 7 10 4 1 0 4 3 2 0 0.819 1.000 1.000 332 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ALDH5A1(1), CAD(1), CPS1(3), EARS2(2), EPRS(3), GLUD1(1), GLUD2(1), GMPS(1), GOT1(1), GOT2(2), GPT2(2), GSS(1), NADSYN1(2), QARS(1) 5408752 22 14 22 5 4 3 5 5 5 0 0.434 1.000 1.000 333 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(1), HS3ST2(3), HS3ST3A1(2), HS3ST5(2), HS6ST1(1), HS6ST2(1), NDST2(1), NDST4(2) 2866477 13 8 13 8 1 0 6 4 2 0 0.960 1.000 1.000 334 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(1), EP300(2), NCOA1(2), NCOA2(1) 2485018 6 6 6 3 0 0 4 1 1 0 0.933 1.000 1.000 335 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CEBPB(1), IL6R(1), JAK1(1), JAK2(2), JAK3(3), PTPN11(1), SRF(1) 3289640 10 8 10 4 2 0 3 4 1 0 0.827 1.000 1.000 336 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 NFKB1(1) 1987187 1 1 1 1 0 0 1 0 0 0 0.949 1.000 1.000 337 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(1), CAPN2(3), CAPNS1(1), EP300(2), HDAC1(1), HDAC2(1), NFATC1(1), PPP3CB(1) 3296266 11 10 11 6 1 0 7 1 2 0 0.911 1.000 1.000 338 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(1), BCL2L1(2), CASP8(1), DAXX(4), DFFA(1), FADD(2), NFKB1(1), NGFR(2), NTRK1(1), PTPN13(2), TNFRSF1A(1) 5997560 18 14 18 9 5 2 3 2 6 0 0.951 1.000 1.000 339 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 IL2(1), MAP3K1(2), NFKB1(1), TNFSF9(2) 2706409 6 5 6 3 2 0 4 0 0 0 0.868 1.000 1.000 340 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(2), CALCR(1), CALCRL(1), CD97(1), ELTD1(2), EMR1(1), EMR2(4), GIPR(1), GLP1R(1), GPR64(1), LPHN1(3), LPHN2(1), LPHN3(3), VIPR1(1), VIPR2(1) 3837139 24 17 23 9 3 1 13 5 2 0 0.689 1.000 1.000 341 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C6(1), C7(1), ICAM1(1), ITGA4(1), ITGAL(1), SELP(2) 3381752 7 6 7 5 1 0 5 0 0 1 0.949 1.000 1.000 342 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(2), BCAT2(1), IARS(1), LARS(1), LARS2(1), PDHB(1), VARS(8), VARS2(1) 2527155 16 14 11 6 1 0 10 3 2 0 0.816 1.000 1.000 343 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP5(1), ACP6(1), ACPP(1), ALPI(1), ALPP(1), ALPPL2(8), DHRS3(1), PON1(1) 2494801 15 13 9 8 0 9 3 2 1 0 0.886 1.000 1.000 344 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 GMPPB(1), HK2(3), HK3(3), KHK(2) 3335159 9 9 9 4 2 0 5 1 1 0 0.728 1.000 1.000 345 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 AOC3(1), MAOA(3) 3371374 4 3 4 4 1 0 1 0 2 0 0.986 1.000 1.000 346 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 DAXX(4), EGFR(3), ETS2(1), MAP2K3(2), MAP3K1(2), MAPK1(1), NFKB1(1), PRKCG(1), PRKCH(1), PRKCQ(2), TNFRSF1A(1) 6512329 19 17 19 7 3 1 6 3 6 0 0.812 1.000 1.000 347 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 BCR(2), JAK2(2), MAP3K1(2), PIK3CA(1), PIK3R1(1), STAT5B(1) 3761721 9 7 9 5 1 0 3 3 2 0 0.964 1.000 1.000 348 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 AOC3(1), DPYD(2), DPYS(2), ECHS1(2), EHHADH(1), HADHA(1), SDS(1) 3932161 10 8 10 5 3 0 4 0 3 0 0.847 1.000 1.000 349 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 CYP2C9(1), DHRS3(1), ECHS1(2), EHHADH(1), ESCO2(1), HADHA(1), PNPLA3(2) 4174357 9 6 9 4 0 0 4 2 3 0 0.876 1.000 1.000 350 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 GNB1(2), MAPK1(1), PLA2G4A(3), PLCB1(3), PTGS1(1), SYK(1) 3303619 11 8 11 6 1 0 6 3 1 0 0.939 1.000 1.000 351 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(1), B3GALNT1(1), B3GALT2(1), B3GALT4(1), B3GALT5(1), FUT3(3), FUT4(1), FUT6(2), GBGT1(2), GCNT2(1), PIGG(2), PIGO(1), PIGU(2), PIGZ(1), ST3GAL1(1), ST6GALNAC3(1), ST6GALNAC5(1) 6770814 23 13 23 5 5 0 9 5 4 0 0.378 1.000 1.000 352 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 IL2(1), JAK1(1), JAK3(3), LCK(1), STAT5B(1), SYK(1) 3252583 8 7 8 4 1 0 4 1 2 0 0.883 1.000 1.000 353 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 EIF1(1), EIF2B5(1), FLT4(6), KDR(1), NOS3(4), PIK3CA(1), PIK3R1(1), PLCG1(3) 4737251 18 16 18 6 6 3 5 4 0 0 0.562 1.000 1.000 354 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(1), CCR3(1), GNAS(5), GNB1(2), MAPK1(1), NOX1(1), PIK3C2G(1), PLCB1(3) 3502131 15 13 15 7 2 0 6 5 2 0 0.917 1.000 1.000 355 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(1), ARF3(1), ARL4D(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0C(1), ATP6V0D2(1), ATP6V1A(1), ATP6V1E2(1), GNAS(5), PDIA4(1), PLCG1(3) 5114318 21 16 21 9 4 2 8 3 4 0 0.846 1.000 1.000 356 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(2), COL4A2(1), COL4A5(2), COL4A6(4), P4HB(1), SLC23A2(1) 3550398 11 10 11 7 2 1 5 1 2 0 0.912 1.000 1.000 357 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 65 APAF1(1), ATM(5), ATR(3), CASP8(1), CCNB3(2), CCND2(1), CDKN2A(2), CHEK2(2), DDB2(1), GADD45G(2), GTSE1(1), IGFBP3(1), MDM2(2), PMAIP1(1), RRM2(1), SERPINE1(1), SESN1(1), THBS1(1), TP53(18), TP53I3(1), TP73(1), TSC2(1) 9011640 50 32 50 11 6 0 14 6 23 1 0.496 1.000 1.000 358 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(1), CDIPT(1), CHAT(1), CHKB(1), CHPT1(2), DGKB(1), DGKD(2), DGKH(1), DGKI(1), DGKZ(6), ESCO2(1), GNPAT(1), GPAM(2), PCYT1B(1), PEMT(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLD2(1), PNPLA3(2), PPAP2C(1) 9197526 34 19 32 8 4 1 15 9 5 0 0.351 1.000 1.000 359 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), B4GALT5(2), MGAT3(1), RPN2(2) 2763978 6 4 6 3 2 0 2 2 0 0 0.874 1.000 1.000 360 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTN1(2), ACTN2(2), CAPNS1(1), SPTAN1(3), TLN1(2) 3982161 10 8 10 4 4 1 4 0 1 0 0.652 1.000 1.000 361 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDHPPT(1), ATP6V0C(1), DLST(1), DOT1L(2), ECHS1(2), EHHADH(1), EHMT1(3), EHMT2(1), HADHA(1), PLOD3(2), SDS(1), SHMT2(1) 5013618 17 10 17 6 3 1 8 1 4 0 0.709 1.000 1.000 362 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F5(2), F8(2), F9(1), LPA(1), PLAT(1), PLG(1), SERPINB2(1), SERPINE1(1), VWF(6) 4757383 16 12 16 8 2 1 6 4 3 0 0.896 1.000 1.000 363 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACSL1(3), ACSL3(2), ADH6(1), ADH7(2), CPT1C(1), CYP4A22(4), ECHS1(2), EHHADH(1), HADH(1), HADHA(1), HADHB(1), HSD17B4(3) 6677058 22 16 22 8 3 2 8 4 5 0 0.771 1.000 1.000 364 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ARRB2(1), CALML3(1), CALML6(1), GNAL(2), PDE1C(1), PRKACA(1), PRKACB(1), PRKG2(2) 4238383 10 9 10 7 2 0 3 3 2 0 0.985 1.000 1.000 365 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(2), AOC3(1), ATP6V0C(1), CHDH(6), CHKB(1), CTH(1), DAO(1), GARS(35), GCAT(2), MAOA(3), PEMT(1), PLCG1(3), SARDH(1), SHMT2(1) 5881043 59 47 21 16 6 1 38 10 4 0 0.314 1.000 1.000 366 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 APOE(9), HMGCR(1), LDLR(1), LRP1(6), SCARB1(3) 3739948 20 15 12 6 6 0 4 9 1 0 0.560 1.000 1.000 367 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(1), CXCR4(1), GNB1(2), MAPK1(1), NFKB1(1), PIK3C2G(1), PIK3CA(1), PIK3R1(1), PLCG1(3) 3887319 12 12 12 9 2 0 7 2 1 0 0.987 1.000 1.000 368 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(1), GNB1(2), MAPK1(1), PDGFRA(1), PIK3CA(1), PIK3R1(1), PLCB1(3), SPHK1(2) 3696675 12 10 12 9 2 0 4 5 1 0 0.990 1.000 1.000 369 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS2(1), ADSS(1), ADSSL1(3), AGXT(2), CAD(1), DDO(1), GOT1(1), GOT2(2), GPT2(2), PC(1), PDHB(1) 5225599 16 14 15 5 5 2 4 3 2 0 0.631 1.000 1.000 370 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 JAK2(2), MPL(1), PIK3CA(1), PIK3R1(1), PLCG1(3), STAT5B(1) 4054873 9 7 9 5 2 0 2 3 2 0 0.964 1.000 1.000 371 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(1), MAP2K3(2), MAP3K1(2), MAPK1(1), PLCG1(3) 3913094 9 8 9 4 3 0 4 2 0 0 0.778 1.000 1.000 372 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 67 APAF1(1), BCL2L1(2), BCL2L11(1), BIRC5(1), CASP8(1), DFFA(1), FADD(2), GZMB(1), HELLS(1), IRF2(3), IRF3(1), IRF4(1), IRF5(1), IRF6(1), MAP3K1(2), MDM2(2), NFKB1(1), NFKBIE(2), PLEKHG5(1), TNFRSF1A(1), TNFRSF21(1), TP53(18), TP73(1) 7937309 47 30 47 12 9 1 15 3 18 1 0.443 1.000 1.000 373 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(1), DUSP1(1), EP300(2), MAP2K3(2), MAPK11(1), NFKB1(1), TGFBR2(2), TLR2(2) 4050233 12 8 12 6 0 0 7 3 2 0 0.956 1.000 1.000 374 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 GAA(1), GALK2(1), HK2(3), HK3(3), LCT(1), MGAM(4) 4470728 13 10 13 5 1 0 8 2 2 0 0.730 1.000 1.000 375 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 BCL2L1(2), CBL(1), JAK1(1), JAK3(3), MAPK1(1), PIK3CA(1), PIK3R1(1), PTPN6(1), STAT5B(1), SYK(1) 4944580 13 11 13 7 2 1 4 3 3 0 0.949 1.000 1.000 376 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 APC(4), AR(2), BRAF(1), EGFR(3), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), PHKA2(2), PIK3CA(1), PIK3R1(1), PITX2(3), PTX3(1) 7420063 30 20 30 8 5 0 13 10 2 0 0.466 1.000 1.000 377 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 CMA1(1), COL4A1(2), COL4A2(1), COL4A5(2), COL4A6(4) 3511236 10 9 10 6 2 1 5 1 1 0 0.890 1.000 1.000 378 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BTK(1), MAP3K1(2), NFATC1(1), PLCG1(3), PPP3CB(1), SYK(1), VAV1(3) 5176187 12 7 12 4 5 0 5 0 2 0 0.640 1.000 1.000 379 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(4), MAPK1(1), MAPK8IP3(2) 3923105 7 4 7 5 0 0 4 2 1 0 0.971 1.000 1.000 380 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(1), CASP8(1), DFFA(1), FADD(2), NFKB1(1), SPTAN1(3), TNFRSF10A(1) 4606724 10 8 10 8 4 1 3 0 2 0 0.983 1.000 1.000 381 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 EIF4G1(1), MAPK1(1), MKNK1(1), PABPC1(5), PIK3CA(1), PIK3R1(1) 3784297 10 10 8 5 1 0 4 4 1 0 0.915 1.000 1.000 382 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 21 BTK(1), EEA1(2), PFKL(2), PLCG1(3), VAV2(1) 3296022 9 8 9 5 3 0 3 2 1 0 0.877 1.000 1.000 383 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 EIF4G1(1), MKNK1(1), PIK3CA(1), PIK3R1(1), TSC2(1) 3771220 5 5 5 5 1 0 2 1 1 0 0.992 1.000 1.000 384 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA2(1), POLD1(2), POLD2(1), POLE(3), POLG(1), POLK(1), POLM(1), POLQ(1), REV3L(1), RFC5(1) 5636804 13 9 12 4 1 1 6 3 2 0 0.778 1.000 1.000 385 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH6(1), ADH7(2), AOC3(1), DBH(2), DCT(1), ESCO2(1), GOT1(1), GOT2(2), HGD(1), LCMT1(1), MAOA(3), MIF(3), PNPLA3(2), TH(3), TPO(22), TYRP1(1), WBSCR22(1) 8111349 48 35 28 13 7 1 32 4 4 0 0.347 1.000 1.000 386 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 IARS(1), IL13RA1(1), IL4R(1), INPP5D(1), JAK1(1), JAK2(2), JAK3(3), PIK3CA(1), SERPINA4(1), SOS2(1), STAT6(1), TYK2(2) 5052012 16 10 16 7 1 1 4 7 3 0 0.872 1.000 1.000 387 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(1), FCER1A(2), MAP3K1(2), MAPK1(1), NFATC1(1), PIK3CA(1), PIK3R1(1), PLA2G4A(3), PLCG1(3), PPP3CB(1), SYK(1), VAV1(3) 5830175 20 11 20 5 5 0 9 3 3 0 0.519 1.000 1.000 388 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG10(1), ALG13(3), ALG2(2), ALG3(1), ALG6(1), MAN2A1(1), MGAT3(1), RPN2(2) 5871798 12 10 12 6 1 0 6 2 3 0 0.884 1.000 1.000 389 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AFMID(1), AOC3(1), ECHS1(2), EHHADH(1), HADH(1), HADHA(1), HSD17B4(3), KMO(1), LCMT1(1), LNX1(2), MAOA(3), OGDHL(1), TDO2(1), WARS2(1), WBSCR22(1) 8279390 21 14 21 6 2 1 11 3 4 0 0.563 1.000 1.000 390 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 G6PC2(1), GAA(1), GALK2(1), HK2(3), HK3(3), LCT(1), MGAM(4), PFKL(2), UGP2(1) 5307105 17 11 17 7 2 0 9 4 2 0 0.780 1.000 1.000 391 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(1), ALDH5A1(1), DDHD1(3), ECHS1(2), EHHADH(1), HADH(1), HADHA(1), HMGCS2(1), HSD17B4(3), OXCT1(1), PDHB(1) 5619878 16 11 15 6 2 0 8 4 2 0 0.777 1.000 1.000 392 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ITGA9(1), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), PDE3A(2), PDE3B(1), PIK3C2G(1), PIK3CA(1), PIK3R1(1), SGCB(1), VASP(1) 6782969 21 15 21 6 2 0 11 7 1 0 0.528 1.000 1.000 393 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(2), ACACB(4), ACSS2(1), GRHPR(1), HAGH(1), LDHA(3), MDH2(1), ME2(1), PC(1), PCK1(1), PDHB(1) 6339221 17 13 17 9 3 1 8 3 2 0 0.943 1.000 1.000 394 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(2), GRHPR(1), HAGH(1), LDHA(3), MDH2(1), ME2(1), PC(1), PCK1(1), PDHB(1) 5007409 12 11 12 9 3 1 5 2 1 0 0.984 1.000 1.000 395 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AOC3(1), CYP2A6(1), CYP2B6(3), CYP2C9(1), CYP2J2(1), CYP4B1(1), ECHS1(2), EHHADH(1), HADHA(1), KMO(1), MAOA(3), SDS(1), TDO2(1), WARS2(1) 7505994 19 12 19 9 3 0 10 2 4 0 0.923 1.000 1.000 396 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC7(1), CDT1(1), DIAPH2(2), MCM3(1), NACA(3), POLA2(1), POLD1(2), POLD2(1), POLE(3), RFC1(1), RFC5(1), RPA2(1), RPA4(1), UBB(1) 6838299 20 13 19 6 3 1 7 6 3 0 0.718 1.000 1.000 397 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CD3D(1), LAT(1), LCK(1), MAP3K1(2), NFATC1(1), NFKB1(1), PIK3CA(1), PIK3R1(1), PLCG1(3), PPP3CB(1), PTPN7(1), VAV1(3), ZAP70(1) 6528357 18 11 18 5 5 0 9 1 3 0 0.547 1.000 1.000 398 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTN1(2), ACTN2(2), BCAR1(1), BCR(2), CAPNS1(1), CSK(1), MAPK1(1), ROCK1(2), TLN1(2), ZYX(1) 6535988 15 12 15 7 3 1 8 1 2 0 0.830 1.000 1.000 399 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(2), BLVRA(1), CP(1), EARS2(2), EPRS(3), MMAB(1), UGT1A3(1), UGT1A5(2), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B15(2), UGT2B28(1) 5676858 23 14 22 7 4 0 12 6 1 0 0.595 1.000 1.000 400 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 MAP3K1(2), MYLK(2), PDGFRA(1), PIK3CA(1), PIK3R1(1), TRIO(1), VAV1(3) 4774573 11 9 11 8 4 0 4 2 1 0 0.985 1.000 1.000 401 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC10(1), CDC16(2), CDC20(1), CDC27(1), CUL3(1), FZR1(2), ITCH(1), WWP1(1), WWP2(1) 5529011 11 9 11 6 1 0 3 6 1 0 0.949 1.000 1.000 402 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF2(2), EIF2AK1(1), EIF2AK3(1), EIF2B5(1), EIF4G1(1), PABPC1(5), PABPC3(3), PAIP1(1) 6061897 15 11 13 7 1 0 7 5 2 0 0.908 1.000 1.000 403 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 GSN(1), MAPK1(1), MYLK(2), PIK3CA(1), PIK3R1(1), ROCK1(2), TLN1(2) 5119802 10 9 10 6 1 0 6 2 1 0 0.943 1.000 1.000 404 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS2(1), CARS2(1), EARS2(2), EPRS(3), FARS2(1), FARSB(1), GARS(35), IARS(1), KARS(1), LARS(1), LARS2(1), MARS(1), MARS2(1), MTFMT(4), QARS(1), RARS2(2), VARS(8), VARS2(1), WARS2(1) 7351696 67 51 28 18 6 1 44 12 4 0 0.440 1.000 1.000 405 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(2), COL4A2(1), COL4A5(2), COL4A6(4), F5(2), F8(2), F9(1), PROC(1), PROS1(1), SERPING1(1) 6156391 17 14 17 9 2 1 8 5 1 0 0.912 1.000 1.000 406 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(4), CCND2(1), CTNNB1(14), DVL1(1), DVL2(1), FZD1(6), FZD5(1), FZD7(1), FZD8(2), LDLR(1), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(2), PRKD1(1), WNT1(2), WNT10A(1), WNT16(1), WNT2(1), WNT2B(1), WNT3(1), WNT4(1), WNT6(1) 7960275 47 31 37 14 5 1 15 10 15 1 0.828 1.000 1.000 407 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 DOCK1(2), GAB1(1), HGF(1), MAPK1(1), PIK3CA(1), PIK3R1(1), PTPN11(1) 6201277 8 7 8 7 0 1 3 3 1 0 0.992 1.000 1.000 408 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ACTG1(1), ARHGEF2(1), CD14(1), CDH1(1), CLDN1(1), CTNNB1(14), NCK2(1), ROCK1(2), TLR4(3), TUBA3E(1), TUBA8(2), TUBAL3(1), TUBB(1), WAS(1) 7059784 31 26 26 10 4 2 12 7 6 0 0.757 1.000 1.000 409 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ACTG1(1), ARHGEF2(1), CD14(1), CDH1(1), CLDN1(1), CTNNB1(14), NCK2(1), ROCK1(2), TLR4(3), TUBA3E(1), TUBA8(2), TUBAL3(1), TUBB(1), WAS(1) 7059784 31 26 26 10 4 2 12 7 6 0 0.757 1.000 1.000 410 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 152 BCL2L1(2), CBL(1), CBLC(1), CCND2(1), CNTFR(1), CREBBP(1), CSF2RA(1), CSF2RB(1), CSF3R(1), EP300(2), EPO(1), GH2(1), IFNA8(1), IFNAR2(1), IFNW1(1), IL13RA1(1), IL2(1), IL21R(2), IL23R(1), IL24(1), IL3(1), IL4R(1), IL6R(1), IL9R(3), IRF9(1), JAK1(1), JAK2(2), JAK3(3), LEPR(2), LIF(1), MPL(1), OSMR(4), PIAS2(2), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PTPN11(1), PTPN6(1), SOCS5(1), SOCS7(1), SOS2(1), SPRED1(1), STAM(1), STAT5B(1), STAT6(1), TPO(22), TYK2(2) 19969646 86 46 67 21 6 4 47 12 17 0 0.341 1.000 1.000 411 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 CREBBP(1), DUSP1(1), EHHADH(1), EP300(2), HSD17B4(3), MAPK1(1), NCOA1(2), NCOR1(1), NCOR2(4), NR2F1(3), NRIP1(3), PIK3CA(1), PIK3R1(1), PPARA(1), PRKACB(1), PRKAR1A(7), PTGS2(1), RB1(2), STAT5B(1) 8612103 37 26 36 11 2 1 12 9 13 0 0.766 1.000 1.000 412 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 237 ADCYAP1R1(2), ADRA2A(2), ADRA2B(1), ADRA2C(4), AVPR1A(3), AVPR1B(1), AVPR2(1), BDKRB2(1), C3AR1(1), CALCR(1), CALCRL(1), CHRM5(1), CYSLTR2(1), DRD3(1), DRD5(1), EDNRB(1), F2RL1(1), FPR1(2), FSHR(1), GABBR1(2), GABRA1(2), GABRA2(2), GABRA6(2), GABRB1(1), GABRB2(1), GABRB3(2), GABRD(1), GABRE(1), GABRG1(1), GABRG2(3), GABRG3(1), GABRR2(1), GALR3(1), GH2(1), GIPR(1), GLP1R(1), GLRA1(3), GLRB(1), GPR156(1), GPR50(4), GPR83(1), GRIA2(3), GRID1(1), GRID2(1), GRIK1(3), GRIK2(2), GRIK4(2), GRIK5(1), GRIN1(1), GRIN2B(2), GRIN2C(2), GRIN2D(1), GRIN3A(4), GRIN3B(7), GRM1(3), GRM3(3), GRM4(1), GRM5(1), GRM6(1), GRM8(4), HCRTR1(1), HTR2A(1), HTR2C(1), HTR5A(3), HTR6(1), KISS1R(3), LEPR(2), MC1R(1), MC3R(1), MCHR1(1), MCHR2(1), MTNR1A(2), MTNR1B(2), NPBWR2(1), NPFFR2(1), NPY1R(1), OPRD1(26), OPRL1(1), P2RX5(1), P2RY14(1), P2RY2(2), P2RY4(1), PARD3(1), PPYR1(3), PRLHR(2), PRSS1(1), PRSS3(1), PTGER4(1), PTGIR(1), RXFP1(1), SSTR1(1), SSTR2(1), SSTR3(2), SSTR4(2), TAAR5(3), TACR3(1), TBXA2R(1), THRA(1), TRPV1(1), UTS2R(4), VIPR1(1), VIPR2(1) 30387635 189 66 154 114 27 8 106 36 12 0 1.000 1.000 1.000 413 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTG1(1), ACTN1(2), ACTN2(2), ACTN4(1), BCAR1(1), BRAF(1), CAPN2(3), CCND2(1), COL11A1(1), COL1A1(1), COL1A2(1), COL2A1(1), COL4A1(2), COL4A2(1), COL4A6(4), COL5A1(5), COL5A2(3), COL5A3(2), COL6A1(2), COL6A2(3), COL6A3(2), COL6A6(2), CTNNB1(14), DOCK1(2), EGFR(3), FARP2(1), FLNA(3), FLNB(1), FLNC(1), FN1(1), HGF(1), IGF1R(1), ITGA10(2), ITGA2(1), ITGA2B(1), ITGA3(2), ITGA4(1), ITGA6(1), ITGA9(1), ITGB4(1), ITGB5(1), ITGB6(1), ITGB8(2), KDR(1), LAMA1(6), LAMA2(7), LAMA3(2), LAMA4(2), LAMA5(3), LAMB3(2), LAMB4(1), LAMC2(2), LAMC3(1), MAPK1(1), MYLK(2), MYLK2(2), PAK3(3), PAK4(1), PAK7(2), PARVG(1), PDGFD(1), PDGFRA(1), PDGFRB(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PIP5K1C(1), PPP1CA(2), PPP1R12A(1), PRKCG(1), RAPGEF1(1), RELN(7), ROCK1(2), SHC2(2), SHC3(1), SOS2(1), THBS1(1), THBS2(2), THBS4(2), TLN1(2), TLN2(6), TNC(3), TNN(4), TNR(5), TNXB(3), VASP(1), VAV1(3), VAV2(1), VAV3(3), VEGFB(1), VTN(1), VWF(6), ZYX(1) 51761335 197 64 192 76 38 10 82 36 30 1 0.945 1.000 1.000 414 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 248 ARRB1(1), ARRB2(1), ATF4(1), BDNF(1), BRAF(1), CACNA1A(10), CACNA1B(6), CACNA1C(1), CACNA1D(3), CACNA1E(3), CACNA1F(3), CACNA1G(2), CACNA1H(3), CACNA1I(2), CACNA1S(2), CACNA2D1(2), CACNA2D4(4), CACNB3(1), CACNB4(1), CACNG3(1), CACNG6(1), CACNG7(1), CD14(1), DAXX(4), DUSP1(1), DUSP6(1), DUSP7(3), ECSIT(1), EGFR(3), ELK4(1), FGF12(1), FGF13(1), FGF19(2), FGF21(1), FGF23(2), FGF3(1), FGF5(1), FGFR2(2), FGFR4(1), FLNA(3), FLNB(1), FLNC(1), GADD45G(2), MAP2K3(2), MAP3K1(2), MAP3K12(1), MAP3K13(1), MAP3K3(1), MAP3K4(1), MAP3K8(1), MAP4K3(1), MAP4K4(1), MAPK1(1), MAPK11(1), MAPK7(2), MAPK8IP3(2), MEF2C(2), MKNK1(1), NF1(9), NFKB1(1), NFKB2(1), NTF3(1), NTRK1(1), NTRK2(1), PDGFRA(1), PDGFRB(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PPP3CB(1), PPP5C(1), PRKACA(1), PRKACB(1), PRKCG(1), PTPN7(1), RAPGEF2(2), RASGRF1(2), RASGRF2(1), RASGRP1(2), RPS6KA1(1), RPS6KA4(2), RPS6KA6(1), SOS2(1), SRF(1), STK4(1), TAOK1(1), TAOK2(6), TAOK3(2), TGFBR2(2), TNFRSF1A(1), TP53(18) 40920000 178 63 169 96 32 10 71 24 40 1 1.000 1.000 1.000 415 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 CADM1(1), CADM3(2), CD276(1), CD8A(1), CD99(1), CDH1(1), CDH2(3), CDH3(1), CDH4(4), CDH5(2), CLDN1(1), CLDN23(13), CLDN5(3), CLDN9(1), CNTN1(2), CNTN2(1), CNTNAP1(1), CNTNAP2(1), CTLA4(2), ESAM(1), F11R(2), HLA-A(4), HLA-B(10), HLA-C(2), HLA-DOB(1), HLA-DQA1(2), HLA-DQB1(3), HLA-DRB1(3), HLA-F(1), HLA-G(1), ICAM1(1), ITGA4(1), ITGA6(1), ITGA9(1), ITGAL(1), ITGAM(2), ITGB8(2), L1CAM(1), MADCAM1(5), MAG(1), NFASC(1), NLGN1(1), NLGN2(4), NRCAM(2), NRXN1(3), NRXN2(3), PTPRF(2), PVR(1), PVRL1(2), PVRL3(1), SDC1(1), SDC4(1), SELE(1), SELP(2), VCAN(3) 20439582 116 57 97 63 21 6 53 23 12 1 0.999 1.000 1.000 416 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 137 ACTG1(1), COL11A1(1), COL17A1(1), COL1A1(1), COL1A2(1), COL2A1(1), COL4A1(2), COL4A2(1), COL4A6(4), COL5A1(5), COL5A2(3), COL5A3(2), COL6A1(2), COL6A2(3), COL6A3(2), COL6A6(2), DSC2(3), DSC3(2), DSG1(2), DSG2(1), DSG3(2), FN1(1), GJA1(2), GJA4(1), GJA8(1), GJB2(1), GJD3(1), GJD4(1), INA(1), ITGA6(1), ITGB4(1), KRT1(2), KRT12(2), KRT14(2), KRT17(1), KRT2(2), KRT20(1), KRT31(1), KRT32(3), KRT33A(1), KRT33B(3), KRT36(1), KRT39(2), KRT40(1), KRT6A(1), KRT71(1), KRT72(2), KRT73(1), KRT74(2), KRT75(1), KRT76(1), KRT77(2), KRT78(1), KRT81(1), KRT83(2), KRT84(1), LAMA1(6), LAMA2(7), LAMA3(2), LAMA4(2), LAMA5(3), LAMB3(2), LAMB4(1), LAMC2(2), LAMC3(1), LMNB1(1), LMNB2(2), RELN(7), THBS1(1), THBS2(2), THBS4(2), TNC(3), TNN(4), TNR(5), TNXB(3), VIM(1), VTN(1), VWF(6) 34657531 155 56 152 77 44 8 66 21 16 0 0.997 1.000 1.000 417 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 169 ADCY1(1), ADCY2(3), ADCY4(1), ADCY7(1), ADCY8(3), ATP2A1(2), ATP2A2(2), ATP2A3(1), ATP2B3(4), AVPR1A(3), AVPR1B(1), BDKRB2(1), BST1(2), CACNA1A(10), CACNA1B(6), CACNA1C(1), CACNA1D(3), CACNA1E(3), CACNA1F(3), CACNA1G(2), CACNA1H(3), CACNA1I(2), CACNA1S(2), CALML3(1), CALML6(1), CHRM5(1), CYSLTR2(1), EDNRB(1), EGFR(3), ERBB3(1), ERBB4(5), GNAL(2), GNAS(5), GRIN1(1), GRIN2C(2), GRIN2D(1), GRM1(3), GRM5(1), HTR2A(1), HTR2C(1), HTR5A(3), HTR6(1), ITPR1(2), ITPR2(4), ITPR3(5), MYLK(2), MYLK2(2), NOS1(2), NOS3(4), P2RX5(1), PDE1A(2), PDE1C(1), PDGFRA(1), PDGFRB(1), PHKA2(2), PHKB(3), PLCB1(3), PLCB3(1), PLCB4(1), PLCE1(2), PLCG1(3), PPP3CB(1), PRKACA(1), PRKACB(1), PRKCG(1), RYR1(4), RYR2(12), RYR3(4), SLC8A1(2), SLC8A2(2), SLC8A3(1), SPHK1(2), SPHK2(2), TACR3(1), TBXA2R(1), TRPC1(1) 38506507 173 55 164 96 39 10 74 30 20 0 1.000 1.000 1.000 418 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 130 ACTG1(1), ACTN1(2), ACTN2(2), ACTN4(1), ASH1L(1), CLDN1(1), CLDN23(13), CLDN5(3), CLDN9(1), CSDA(1), CTNNA2(1), CTNNA3(1), CTNNB1(14), EPB41(1), EPB41L1(1), EPB41L3(1), EXOC3(1), F11R(2), INADL(1), LLGL2(1), MAGI1(2), MAGI2(4), MAGI3(2), MPDZ(4), MPP5(1), MYH11(2), MYH13(1), MYH14(3), MYH15(3), MYH2(2), MYH3(2), MYH4(3), MYH6(4), MYH7(1), MYH8(4), PARD3(1), PPP2R1B(1), PPP2R3A(1), PPP2R3B(2), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(2), SPTAN1(3), SYMPK(2), TJAP1(1), TJP1(1), TJP2(1), TJP3(3), VAPA(1) 26660823 110 54 90 38 20 6 51 20 13 0 0.745 1.000 1.000 419 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 252 ACVR1(1), ACVR2B(1), AMH(1), AMHR2(1), BMPR1A(2), BMPR1B(1), BMPR2(1), CCL11(1), CCR3(1), CCR4(1), CCR6(2), CCR9(1), CNTFR(1), CSF1R(1), CSF2RA(1), CSF2RB(1), CSF3R(1), CX3CL1(1), CX3CR1(2), CXCL1(1), CXCL3(1), CXCL9(2), CXCR3(2), CXCR4(1), EGFR(3), EPO(1), FLT4(6), GDF5(1), GH2(1), HGF(1), IFNA8(1), IFNAR2(1), IFNW1(1), IL13RA1(1), IL17A(1), IL17RA(2), IL18R1(2), IL2(1), IL21R(2), IL23R(1), IL24(1), IL25(1), IL3(1), IL4R(1), IL6R(1), IL9R(3), INHBA(2), INHBB(3), KDR(1), LEPR(2), LIF(1), MPL(1), NGFR(2), OSMR(4), PDGFRA(1), PDGFRB(1), TGFBR2(2), TNFRSF10A(1), TNFRSF11A(1), TNFRSF1A(1), TNFRSF21(1), TNFRSF6B(1), TNFSF11(1), TNFSF9(2), TPO(22), VEGFB(1), XCL1(1) 24456563 115 51 95 43 23 4 62 14 12 0 0.738 1.000 1.000 420 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 163 ADRA2A(2), ADRA2C(4), AVPR1A(3), AVPR1B(1), AVPR2(1), BDKRB2(1), C3AR1(1), CCR3(1), CCR4(1), CCR6(2), CCR9(1), CHRM5(1), CX3CR1(2), CXCR3(2), CXCR4(1), DRD3(1), DRD5(1), EDNRB(1), F2RL1(1), FPR1(2), FSHR(1), GALR3(1), GPR173(2), GPR174(1), GPR3(1), GPR37(1), GPR4(3), GPR50(4), GPR6(1), GPR83(1), GPR85(1), HCRTR1(1), HTR2A(1), HTR2C(1), HTR5A(3), HTR6(1), MC1R(1), MC3R(1), MTNR1A(2), MTNR1B(2), NPY1R(1), OPRD1(26), OPRL1(1), OR2H1(1), OR7A5(1), P2RY12(1), P2RY14(1), P2RY2(2), PPYR1(3), PTGER4(1), PTGIR(1), SSTR1(1), SSTR2(1), SSTR3(2), SSTR4(2), TBXA2R(1) 16443523 106 50 77 70 16 3 63 19 5 0 1.000 1.000 1.000 421 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(1), COL11A1(1), COL1A1(1), COL1A2(1), COL2A1(1), COL4A1(2), COL4A2(1), COL4A6(4), COL5A1(5), COL5A2(3), COL5A3(2), COL6A1(2), COL6A2(3), COL6A3(2), COL6A6(2), FN1(1), FNDC1(3), GP6(2), GP9(2), HMMR(1), HSPG2(5), ITGA10(2), ITGA2(1), ITGA2B(1), ITGA3(2), ITGA4(1), ITGA6(1), ITGA9(1), ITGB4(1), ITGB5(1), ITGB6(1), ITGB8(2), LAMA1(6), LAMA2(7), LAMA3(2), LAMA4(2), LAMA5(3), LAMB3(2), LAMB4(1), LAMC2(2), LAMC3(1), RELN(7), SDC1(1), SDC4(1), SV2C(1), THBS1(1), THBS2(2), THBS4(2), TNC(3), TNN(4), TNR(5), TNXB(3), VTN(1), VWF(6) 31583923 122 49 120 47 24 7 55 23 12 1 0.853 1.000 1.000 422 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), ARRB1(1), ARRB2(1), ATP1A4(2), ATP1B1(1), ATP2A2(2), ATP2A3(1), ATP2B3(4), CACNA1A(10), CACNA1B(6), CACNA1C(1), CACNA1D(3), CACNA1E(3), CACNA1S(2), CACNB3(1), CHRM5(1), GJA1(2), GJA4(1), GJB2(1), GNB1(2), GRK4(1), ITPR1(2), ITPR2(4), ITPR3(5), KCNB1(1), PLCB3(1), PRKACA(1), PRKACB(1), PRKAR1A(7), PRKCG(1), PRKCH(1), PRKCQ(2), PRKD1(1), RGS1(1), RGS10(1), RGS18(3), RGS3(1), RYR1(4), RYR2(12), RYR3(4), SLC8A1(2), SLC8A3(1) 26587124 115 48 105 63 20 10 49 16 20 0 1.000 1.000 1.000 423 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 202 ACTN1(2), ACTN2(2), ACTN4(1), APC(4), APC2(2), ARHGEF1(1), ARHGEF4(2), ARPC2(1), BCAR1(1), BDKRB2(1), BRAF(1), CD14(1), CHRM5(1), CSK(1), CYFIP1(1), CYFIP2(2), DIAPH2(2), DIAPH3(1), DOCK1(2), EGFR(3), FGF12(1), FGF13(1), FGF19(2), FGF21(1), FGF23(2), FGF3(1), FGF5(1), FGFR2(2), FGFR4(1), FN1(1), GIT1(1), GSN(1), IQGAP2(1), IQGAP3(1), ITGA10(2), ITGA2(1), ITGA2B(1), ITGA3(2), ITGA4(1), ITGA6(1), ITGA9(1), ITGAE(1), ITGAL(1), ITGAM(2), ITGAX(1), ITGB4(1), ITGB5(1), ITGB6(1), ITGB8(2), LIMK2(1), MAPK1(1), MYH14(3), MYLK(2), MYLK2(2), NCKAP1(1), PAK3(3), PAK4(1), PAK7(2), PDGFRA(1), PDGFRB(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PIP4K2B(1), PIP5K1C(1), PPP1CA(2), PPP1R12A(1), ROCK1(2), SCIN(1), SLC9A1(1), SOS2(1), SSH1(1), TIAM1(3), TIAM2(3), VAV1(3), VAV2(1), VAV3(3), WAS(1), WASF2(1) 38882321 119 47 117 56 16 7 53 23 19 1 0.997 1.000 1.000 424 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 145 APC(4), APC2(2), CCND2(1), CHD8(1), CREBBP(1), CTBP2(4), CTNNB1(14), DAAM1(2), DAAM2(2), DKK1(1), DKK2(1), DVL1(1), DVL2(1), EP300(2), FZD1(6), FZD5(1), FZD7(1), FZD8(2), LRP6(1), NFATC1(1), NKD1(1), NKD2(1), PLCB1(3), PLCB3(1), PLCB4(1), PPP2R1B(1), PPP3CB(1), PRICKLE2(1), PRKACA(1), PRKACB(1), PRKCG(1), ROCK1(2), TBL1X(3), TCF7L2(1), TP53(18), WIF1(1), WNT1(2), WNT10A(1), WNT16(1), WNT2(1), WNT2B(1), WNT3(1), WNT4(1), WNT6(1) 22181187 96 46 85 45 11 3 29 18 33 2 1.000 1.000 1.000 425 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABLIM1(2), ABLIM2(1), ABLIM3(3), CXCR4(1), DCC(1), EFNA2(1), EPHA1(2), EPHA2(1), EPHA5(2), EPHA6(2), EPHA8(3), EPHB1(1), EPHB3(2), EPHB4(2), EPHB6(1), L1CAM(1), LIMK2(1), LRRC4C(3), MAPK1(1), NCK2(1), NFATC1(1), NTN1(1), NTN4(2), NTNG1(2), PAK3(3), PAK4(1), PAK7(2), PLXNA1(3), PLXNA2(4), PLXNA3(3), PLXNB2(3), PLXNB3(7), PLXNC1(1), PPP3CB(1), RGS3(1), RHOD(2), RND1(1), ROBO1(3), ROBO2(4), ROBO3(1), ROCK1(2), SEMA3D(3), SEMA3E(1), SEMA3G(2), SEMA4F(1), SEMA4G(1), SEMA5A(3), SEMA5B(17), SEMA6A(2), SEMA6B(1), SEMA6C(1), SEMA6D(2), SLIT1(2), SLIT2(6), UNC5A(2), UNC5B(1), UNC5C(2), UNC5D(2) 27496111 129 46 112 45 29 8 56 27 9 0 0.584 1.000 1.000 426 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(2), ASCC3(1), ATP13A2(1), DDX18(2), DDX4(2), DDX50(2), EP400(4), ERCC2(19), ERCC3(1), G6PC2(1), GAA(1), HK2(3), HK3(3), LYZL1(2), MGAM(4), MOV10L1(1), PYGL(1), RAD54B(1), RUVBL2(1), SETX(2), SI(5), SMARCA2(4), SMARCA5(1), UGP2(1), UGT1A3(1), UGT1A5(2), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B15(2), UGT2B28(1) 16973407 78 45 58 25 23 1 28 12 13 1 0.700 1.000 1.000 427 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(2), ACTN2(2), ACTN4(1), BCAR1(1), CD99(1), CDH5(2), CLDN1(1), CLDN23(13), CLDN5(3), CLDN9(1), CTNNA2(1), CTNNA3(1), CTNNB1(14), CXCR4(1), ESAM(1), F11R(2), ICAM1(1), ITGA4(1), ITGAL(1), ITGAM(2), ITK(1), MAPK11(1), MMP9(1), NOX1(1), NOX3(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PLCG1(3), PRKCG(1), PTPN11(1), RAPGEF3(1), RASSF5(3), ROCK1(2), VASP(1), VAV1(3), VAV2(1), VAV3(3) 17302380 83 44 66 24 11 2 39 17 13 1 0.543 1.000 1.000 428 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), CALML3(1), CALML6(1), CREB3L1(1), CREB3L3(2), CREBBP(1), CTNNB1(14), DCT(1), DVL1(1), DVL2(1), EDNRB(1), EP300(2), FZD1(6), FZD5(1), FZD7(1), FZD8(2), GNAS(5), MAPK1(1), MC1R(1), PLCB1(3), PLCB3(1), PLCB4(1), PRKACA(1), PRKACB(1), PRKCG(1), TCF7L2(1), TYRP1(1), WNT1(2), WNT10A(1), WNT16(1), WNT2(1), WNT2B(1), WNT3(1), WNT4(1), WNT6(1) 15094916 75 44 64 33 9 2 26 16 21 1 0.994 1.000 1.000 429 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 91 ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), AKAP1(2), AKAP11(1), AKAP12(4), AKAP2(7), AKAP4(2), AKAP5(1), AKAP6(1), AKAP8(2), AKAP9(3), ARHGEF1(1), GNAL(2), GNB1(2), ITPR1(2), PDE1A(2), PDE1C(1), PDE4B(1), PDE4C(2), PDE4D(1), PDE8A(1), PDE8B(2), PLCB3(1), PRKACA(1), PRKACB(1), PRKAR1A(7), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(2), PRKD1(1), SLC9A1(1) 16025462 70 43 62 31 15 1 25 12 17 0 0.981 1.000 1.000 430 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), ADSS(1), ADSSL1(3), AK5(2), ENTPD2(1), ENTPD4(3), ENTPD8(1), GDA(1), GMPS(1), GUCY1A3(1), GUCY2D(3), GUCY2F(2), IMPDH1(1), NME6(1), NT5C1A(1), NT5C1B(2), NT5E(1), NT5M(1), NUDT2(1), NUDT9(2), PAPSS2(1), PDE10A(1), PDE1A(2), PDE1C(1), PDE2A(1), PDE3B(1), PDE4B(1), PDE4C(2), PDE4D(1), PDE8A(1), PDE8B(2), PDE9A(1), POLA2(1), POLD1(2), POLD2(1), POLE(3), POLR1A(1), POLR1C(2), POLR2B(2), POLR2H(1), PRPS1L1(1), RFC5(1), RRM2(1), XDH(3) 22665622 76 43 73 35 11 6 35 17 7 0 0.982 1.000 1.000 431 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 ATP8A1(1), AVPR1A(3), AVPR1B(1), AVPR2(1), BDKRB2(1), C3AR1(1), CCR3(1), CCR4(1), CCR6(2), CX3CR1(2), CXCR3(2), CXCR4(1), EDNRB(1), FPR1(2), FSHR(1), GALR3(1), MC1R(1), MC3R(1), NPY1R(1), OPRD1(26), OPRL1(1), PPYR1(3), SSTR1(1), SSTR2(1), SSTR3(2), SSTR4(2), TACR3(1) 6997313 62 43 36 28 8 1 45 6 2 0 0.794 1.000 1.000 432 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 137 ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), ADM(1), ARRB1(1), ARRB2(1), ATF4(1), ATP2A2(2), ATP2A3(1), CACNB3(1), CALCA(1), CNN1(1), CORIN(1), DGKZ(6), ETS2(1), GABPB2(1), GJA1(2), GNB1(2), GRK4(1), GUCY1A3(1), IGFBP1(1), IGFBP3(1), IGFBP6(1), ITPR1(2), ITPR2(4), ITPR3(5), MYLK2(2), NFKB1(1), NOS1(2), NOS3(4), PDE4B(1), PDE4D(1), PLCB3(1), PLCG1(3), PRKACA(1), PRKACB(1), PRKAR1A(7), PRKCH(1), PRKCQ(2), PRKD1(1), RAMP3(2), RGS1(1), RGS10(1), RGS18(3), RGS3(1), RYR1(4), RYR2(12), RYR3(4), SLC8A1(2), TNXB(3) 24381283 113 43 109 69 16 7 50 22 18 0 1.000 1.000 1.000 433 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 CABIN1(1), CEBPB(1), CREBBP(1), CTLA4(2), EGR2(1), EGR3(1), EP300(2), FCER1A(2), FCGR3A(3), GATA3(2), GATA4(1), IL2(1), IL3(1), ITK(1), KPNA5(1), NCK2(1), NFATC1(1), NFKB2(1), NFKBIE(2), NUP214(2), OPRD1(26), PIN1(1), PPP3CB(1), RPL13A(1), SLA(2), VAV1(3), VAV2(1), VAV3(3) 12563088 66 40 41 36 4 0 50 6 6 0 0.999 1.000 1.000 434 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), EGFR(3), GJA1(2), GNAS(5), GRM1(3), GRM5(1), GUCY1A3(1), GUCY2D(3), GUCY2F(2), HTR2A(1), HTR2C(1), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), MAPK7(2), PDGFD(1), PDGFRA(1), PDGFRB(1), PLCB1(3), PLCB3(1), PLCB4(1), PRKACA(1), PRKACB(1), PRKCG(1), PRKG2(2), SOS2(1), TJP1(1), TUBA3E(1), TUBA8(2), TUBAL3(1), TUBB(1) 18323121 69 39 67 37 15 1 26 17 10 0 0.994 1.000 1.000 435 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 82 AIFM1(1), APAF1(1), ATM(5), BCL2L1(2), CAPN2(3), CASP8(1), CSF2RB(1), DFFA(1), FADD(2), IL3(1), IRAK1(2), IRAK2(2), NFKB1(1), NFKB2(1), NTRK1(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PPP3CB(1), PRKACA(1), PRKACB(1), PRKAR1A(7), TNFRSF10A(1), TNFRSF1A(1), TP53(18) 11573862 62 38 60 37 7 2 19 6 27 1 1.000 1.000 1.000 436 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), ADSS(1), AK5(2), ATP1B1(1), ATP5F1(1), ENTPD2(1), GDA(1), GMPS(1), GUCY1A3(1), GUCY2D(3), GUCY2F(2), IMPDH1(1), NT5E(1), NT5M(1), NUDT2(1), PAPSS2(1), PDE1A(2), PDE4B(1), PDE4C(2), PDE4D(1), PDE8A(1), PDE9A(1), POLD1(2), POLD2(1), POLE(3), POLG(1), POLQ(1), POLR2B(2), POLR2H(1), POLRMT(5), PRPS1L1(1), RRM2(1) 17761306 58 38 53 30 10 9 22 12 5 0 0.991 1.000 1.000 437 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(1), ADCY6(2), ADCY8(3), CACNA1A(10), CACNA1B(6), GNAS(5), GNB1(2), GRM4(1), ITPR3(5), KCNB1(1), PDE1A(2), PRKACA(1), PRKACB(1), SCNN1A(2), SCNN1B(2), TAS1R2(1), TAS2R3(1), TAS2R38(1), TAS2R4(1), TAS2R40(1), TAS2R41(1), TAS2R42(1), TAS2R43(4), TAS2R46(1), TAS2R5(1), TAS2R50(1) 8059546 58 37 51 26 8 6 34 5 5 0 0.925 1.000 1.000 438 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 84 CD14(1), CD19(2), CD1A(1), CD1C(1), CD1E(1), CD3D(1), CD8A(1), CD9(1), CR1(1), CR2(2), CSF1R(1), CSF2RA(1), CSF3R(1), EPO(1), GP9(2), HLA-DRB1(3), IL3(1), IL4R(1), IL6R(1), IL9R(3), ITGA2(1), ITGA2B(1), ITGA3(2), ITGA4(1), ITGA6(1), ITGAM(2), MME(3), TPO(22) 11331747 60 36 40 21 4 3 43 5 4 1 0.755 1.000 1.000 439 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 110 ANAPC10(1), ATM(5), ATR(3), CCNB3(2), CCND2(1), CDC14A(1), CDC16(2), CDC20(1), CDC27(1), CDC7(1), CDKN2A(2), CHEK2(2), CREBBP(1), DBF4(3), E2F3(1), EP300(2), ESPL1(1), FZR1(2), GADD45G(2), HDAC1(1), HDAC2(1), MAD1L1(1), MAD2L2(1), MCM3(1), MDM2(2), PRKDC(3), RB1(2), RBL1(1), SMC1A(2), TFDP1(1), TP53(18) 18617033 68 35 68 27 11 2 20 6 28 1 0.984 1.000 1.000 440 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(1), CANX(1), CD8A(1), CIITA(2), CTSL1(1), HLA-A(4), HLA-B(10), HLA-C(2), HLA-DOB(1), HLA-DQA1(2), HLA-DQB1(3), HLA-DRB1(3), HLA-F(1), HLA-G(1), HSP90AA1(1), HSP90AB1(1), HSPA5(1), IFNA8(1), KIR2DL1(1), KIR3DL2(1), NFYA(1), TAP1(1), TAP2(1) 6324416 42 35 39 22 2 4 15 13 8 0 0.997 1.000 1.000 441 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 BRAF(1), CACNA1A(10), GNAS(5), GRIA2(3), GRID2(1), GRM1(3), GRM5(1), GUCY1A3(1), GUCY2D(3), GUCY2F(2), IGF1R(1), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), NOS1(2), NOS3(4), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLCB1(3), PLCB3(1), PLCB4(1), PPP2R1B(1), PRKCG(1), PRKG2(2), RYR1(4) 15489759 69 35 66 47 10 1 31 18 9 0 1.000 1.000 1.000 442 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(1), ADCY2(3), ADCY4(1), ADCY5(2), ADCY6(2), ADCY7(1), ADCY8(3), ATF4(1), CACNA1C(1), CACNA1D(3), CACNA1F(3), CACNA1S(2), CALML3(1), CALML6(1), EGFR(3), GNAS(5), ITPR1(2), ITPR2(4), ITPR3(5), MAP2K3(2), MAP3K1(2), MAP3K3(1), MAP3K4(1), MAPK1(1), MAPK11(1), MAPK7(2), MMP14(2), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLCB1(3), PLCB3(1), PLCB4(1), PLD2(1), PRKACA(1), PRKACB(1), SOS2(1) 18055249 72 35 68 30 16 1 29 14 12 0 0.931 1.000 1.000 443 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 57 ASH1L(1), CTCFL(2), DOT1L(2), EHMT1(3), EHMT2(1), HCFC1(2), JMJD4(6), MEN1(8), MLL(5), MLL2(4), MLL3(7), MLL4(8), MLL5(1), NSD1(3), OGT(1), PPP1CA(2), PRDM6(2), PRDM9(5), SETD1A(1), SETD1B(2), SETD2(3), SETDB1(1), SETDB2(1), SETMAR(1), SUV420H1(1), WHSC1(1), WHSC1L1(1) 17382521 75 34 69 20 18 1 20 9 26 1 0.592 1.000 1.000 444 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACTG1(1), ACTN1(2), ACTN2(2), ACTN4(1), CDH1(1), CREBBP(1), CTNNA2(1), CTNNA3(1), CTNNB1(14), EGFR(3), EP300(2), FARP2(1), IGF1R(1), INSR(1), MAPK1(1), PARD3(1), PTPN6(1), PTPRF(2), PTPRJ(3), PVRL1(2), PVRL3(1), PVRL4(1), SORBS1(1), TCF7L2(1), TGFBR2(2), TJP1(1), WAS(1), WASF2(1) 16514835 51 34 46 18 9 2 21 9 10 0 0.815 1.000 1.000 445 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ATM(5), CCNB3(2), CCND2(1), CDC14A(1), CDC20(1), CDC7(1), CDH1(1), CDKN2A(2), CHEK2(2), DTX4(1), E2F3(1), EP300(2), ESPL1(1), HDAC1(1), HDAC2(1), HDAC4(1), HDAC6(2), MAD1L1(1), MAD2L2(1), MCM3(1), MDM2(2), MPL(1), PRKDC(3), PTPRA(1), RB1(2), RBL1(1), TBC1D8(2), TFDP1(1), TP53(18) 15264303 60 33 60 27 9 2 19 4 25 1 0.992 1.000 1.000 446 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 81 ACVR1(1), AURKB(1), BMPR1A(2), BMPR2(1), CDIPT(1), CLK1(2), CLK2(1), COL4A3BP(1), DGKB(1), DGKD(2), DGKH(1), DGKZ(6), INPP4A(2), NEK1(1), OCRL(1), PAK4(1), PIK3C2G(1), PIK3CA(1), PIK3CB(1), PLCB1(3), PLCB3(1), PLCB4(1), PLCG1(3), PRKACA(1), PRKACB(1), PRKAR1A(7), PRKCG(1), PRKCH(1), PRKCQ(2), PRKD1(1), RPS6KA1(1), RPS6KA4(2), STK11(2) 15803361 55 33 52 40 11 2 14 13 15 0 1.000 1.000 1.000 447 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 ALG2(2), BFAR(1), BTK(1), CAD(1), CASP8(1), DAXX(4), DFFA(1), EGFR(3), FADD(2), MAP3K1(2), MAPK1(1), MAPK8IP3(2), NFKB1(1), NFKB2(1), NFKBIE(2), PTPN13(2), ROCK1(2), TNFRSF6B(1), TP53(18) 10226815 48 33 48 36 8 2 16 5 16 1 1.000 1.000 1.000 448 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 CREBBP(1), CTBP2(4), DLL1(1), DLL3(1), DTX2(2), DTX4(1), DVL1(1), DVL2(1), EP300(2), HDAC1(1), HDAC2(1), JAG2(1), MAML1(1), MAML3(2), NCOR2(4), NOTCH1(4), NOTCH2(11), NOTCH3(3), NOTCH4(2), PTCRA(2), RBPJL(2), SNW1(2) 9938986 50 32 38 33 7 14 15 7 7 0 1.000 1.000 1.000 449 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 BRAF(1), CD247(1), FCGR3A(3), GZMB(1), HLA-A(4), HLA-B(10), HLA-C(2), HLA-G(1), ICAM1(1), IFNA8(1), IFNAR2(1), ITGAL(1), KIR2DL1(1), KIR3DL2(1), LAT(1), LCK(1), MAPK1(1), MICA(2), MICB(1), NFATC1(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PLCG1(3), PPP3CB(1), PRKCG(1), PTPN11(1), PTPN6(1), SHC2(2), SHC3(1), SOS2(1), SYK(1), TNFRSF10A(1), VAV1(3), VAV2(1), VAV3(3), ZAP70(1) 15544815 64 32 61 21 11 4 21 12 16 0 0.800 1.000 1.000 450 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 65 ATM(5), CCND2(1), CDKN2A(2), CREB3L1(1), CREB3L3(2), E2F3(1), MCM3(1), MDM2(2), NACA(3), POLA2(1), POLE(3), RB1(2), RBL1(1), RPA2(1), TFDP1(1), TNXB(3), TP53(18) 10476255 48 31 47 22 8 2 13 4 20 1 0.983 1.000 1.000 451 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(1), EGFR(3), ERBB4(5), ETS2(1), FMN2(3), MAPK1(1), NOTCH1(4), NOTCH2(11), NOTCH3(3), NOTCH4(2), PIWIL1(1), PIWIL3(2), SOS2(1), SPIRE2(4) 7213331 42 29 30 18 7 12 10 7 6 0 0.920 1.000 1.000 452 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP5F1(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0C(1), ATP6V0D2(1), ATP6V1A(1), ATP6V1E2(1), COX4I1(1), COX4I2(1), COX6B1(1), COX7A1(1), LHPP(2), NDUFA1(1), NDUFA10(2), NDUFA12(1), NDUFB10(1), NDUFB11(2), NDUFB5(2), NDUFB7(1), NDUFB8(1), NDUFS2(1), PPA1(1), SDHA(1), SDHB(1), SDHD(1), TCIRG1(1), UQCRFS1(12) 7782988 45 28 33 17 4 2 15 18 6 0 0.898 1.000 1.000 453 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(1), ADCY8(3), ATF4(1), BRAF(1), CACNA1C(1), CALML3(1), CALML6(1), CREBBP(1), EP300(2), GRIA2(3), GRIN1(1), GRIN2B(2), GRIN2C(2), GRIN2D(1), GRM1(3), GRM5(1), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), PLCB1(3), PLCB3(1), PLCB4(1), PPP1CA(2), PPP1R12A(1), PPP3CB(1), PRKACA(1), PRKACB(1), PRKCG(1), RAPGEF3(1), RPS6KA1(1), RPS6KA6(1) 14091561 52 28 51 35 10 1 17 13 11 0 1.000 1.000 1.000 454 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALML3(1), CALML6(1), CDIPT(1), DGKB(1), DGKD(2), DGKH(1), DGKI(1), DGKZ(6), INPP4A(2), INPP5B(1), INPP5D(1), ITPR1(2), ITPR2(4), ITPR3(5), OCRL(1), PI4KA(4), PIK3C2G(1), PIK3C3(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PIP4K2B(1), PIP5K1C(1), PLCB1(3), PLCB3(1), PLCB4(1), PLCE1(2), PLCG1(3), PRKCG(1), SYNJ1(1) 17536808 57 27 55 35 10 1 22 18 6 0 1.000 1.000 1.000 455 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 89 ACVR1(1), ACVR2B(1), AMH(1), AMHR2(1), BMP6(1), BMP8A(3), BMP8B(1), BMPR1A(2), BMPR1B(1), BMPR2(1), CHRD(2), CREBBP(1), DCN(2), EP300(2), GDF5(1), GDF6(1), ID1(1), INHBA(2), INHBB(3), LEFTY2(1), LTBP1(1), MAPK1(1), NOG(1), PITX2(3), PPP2R1B(1), RBL1(1), ROCK1(2), SMAD6(1), SMAD7(1), TFDP1(1), TGFBR2(2), THBS1(1), THBS2(2), THBS4(2), ZFYVE16(1), ZFYVE9(3) 13481802 53 27 51 30 15 2 22 13 1 0 0.993 1.000 1.000 456 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 BCAR1(1), CAPN2(3), CAPN6(4), CAPN9(1), CAPNS1(1), CSK(1), DOCK1(2), ITGA10(2), ITGA2(1), ITGA2B(1), ITGA3(2), ITGA4(1), ITGA6(1), ITGA9(1), ITGAE(1), ITGAL(1), ITGAM(2), ITGAX(1), ITGB4(1), ITGB5(1), ITGB6(1), ITGB8(2), MAP2K3(2), MAPK7(2), MYLK2(2), PAK3(3), PAK4(1), PIK3R2(1), RAPGEF1(1), ROCK1(2), SHC3(1), SORBS1(1), TLN1(2), TNS1(3), VASP(1), VAV2(1), VAV3(3), ZYX(1) 18864789 59 27 58 22 8 0 34 10 6 1 0.778 1.000 1.000 457 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 ALG10(1), ALG13(3), ALG2(2), ALG3(1), ALG6(1), B3GNT6(4), B4GALT5(2), B4GALT7(1), C1GALT1(1), CHPF(2), CHST11(1), CHST13(3), CHST3(1), EXT1(1), GALNT10(1), GALNT12(2), GALNT14(1), GALNT3(2), GALNT4(1), GALNT5(1), GALNT8(2), HS3ST2(3), HS3ST3A1(2), HS3ST5(2), HS6ST1(1), HS6ST2(1), MAN2A1(1), MGAT3(1), NDST2(1), NDST4(2), OGT(1), RPN2(2), ST3GAL1(1), ST6GALNAC1(1), XYLT1(1) 15206156 54 26 50 26 6 4 19 13 12 0 0.985 1.000 1.000 458 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(2), ACACB(4), BRAF(1), CALML3(1), CALML6(1), CBL(1), CBLC(1), FASN(3), G6PC2(1), INPP5D(1), INSR(1), IRS4(1), LIPE(2), MAPK1(1), MKNK1(1), PCK1(1), PDE3A(2), PDE3B(1), PFKL(2), PHKA2(2), PHKB(3), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PPARGC1A(2), PPP1CA(2), PPP1R3A(1), PRKAA2(1), PRKACA(1), PRKACB(1), PRKAG2(3), PRKAG3(1), PRKAR1A(7), PRKCI(1), PTPRF(2), PYGL(1), RAPGEF1(1), SHC2(2), SHC3(1), SORBS1(1), SOS2(1), TSC2(1) 22419003 70 26 69 39 14 3 17 16 20 0 1.000 1.000 1.000 459 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ATM(5), ATR(3), CDKN2A(2), HDAC1(1), RB1(2), TFDP1(1), TP53(18) 4063077 32 25 32 10 4 0 8 2 17 1 0.878 1.000 1.000 460 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA12(3), ABCA13(2), ABCA2(2), ABCA3(1), ABCA5(2), ABCA6(3), ABCA7(2), ABCB1(1), ABCB11(1), ABCB4(2), ABCB5(1), ABCC1(1), ABCC10(1), ABCC11(4), ABCC12(1), ABCC2(2), ABCC3(2), ABCC5(1), ABCC6(2), ABCC9(1), ABCD1(1), ABCD2(1), ABCD4(1), ABCG5(1), CFTR(2), TAP1(1), TAP2(1) 16469235 43 25 43 45 7 2 18 6 10 0 1.000 1.000 1.000 461 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 BDKRB2(1), C1QC(1), C1S(1), C2(1), C3AR1(1), C6(1), C7(1), C8B(1), C9(3), CFB(1), CFD(1), CFH(2), CR1(1), CR2(2), F13A1(1), F5(2), F8(2), F9(1), KNG1(1), PLAT(1), PLG(1), PROC(1), PROS1(1), SERPINA1(1), SERPIND1(1), SERPINE1(1), SERPING1(1), TFPI(1), VWF(6) 12458659 40 25 40 17 9 2 13 10 6 0 0.861 1.000 1.000 462 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(5), ATR(3), CHEK2(2), EP300(2), MDM2(2), PRKDC(3), RPS6KA1(1), TP53(18) 5842035 36 24 36 17 3 0 10 3 19 1 0.996 1.000 1.000 463 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 99 CASP8(1), CD14(1), CXCL9(2), FADD(2), IFNA8(1), IFNAR2(1), IRAK1(2), IRF3(1), IRF5(1), LBP(1), MAP2K3(2), MAP3K8(1), MAPK1(1), MAPK11(1), NFKB1(1), NFKB2(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), TICAM1(1), TLR2(2), TLR4(3), TLR6(1), TLR7(1), TLR9(2) 12276388 37 24 36 38 4 3 14 10 6 0 1.000 1.000 1.000 464 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTN2(2), ACTN4(1), DMD(4), MYBPC1(1), MYBPC2(1), MYH3(2), MYH6(4), MYH7(1), MYH8(4), MYL1(1), MYOM1(1), NEB(7), TNNT1(1), TNNT2(1), TPM2(2), TTN(26), VIM(1) 19079615 60 24 60 24 8 7 25 13 7 0 0.917 1.000 1.000 465 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 CAD(1), DHODH(3), DPYD(2), DPYS(2), ENTPD4(3), ENTPD8(1), NME6(1), NT5C1A(1), NT5C1B(2), NT5E(1), NT5M(1), NUDT2(1), POLA2(1), POLD1(2), POLD2(1), POLE(3), POLR1A(1), POLR1C(2), POLR2B(2), POLR2H(1), RFC5(1), RRM2(1), UCK2(1) 11282709 35 23 33 14 6 4 14 5 6 0 0.881 1.000 1.000 466 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 AMDHD1(18), AOC3(1), LCMT1(1), MAOA(3), UROC1(1), WBSCR22(1) 5514870 25 23 8 22 1 1 3 18 2 0 1.000 1.000 1.000 467 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 93 CARD11(3), CBL(1), CBLC(1), CD247(1), CD3D(1), CD8A(1), CTLA4(2), IL2(1), ITK(1), LAT(1), LCK(1), MAP3K8(1), NCK2(1), NFATC1(1), NFKB1(1), NFKB2(1), NFKBIE(2), PAK3(3), PAK4(1), PAK7(2), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PLCG1(3), PPP3CB(1), PRKCQ(2), PTPN6(1), RASGRP1(2), SOS2(1), TEC(1), VAV1(3), VAV2(1), VAV3(3), ZAP70(1) 13957564 53 23 53 43 8 3 23 8 11 0 1.000 1.000 1.000 468 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 71 ACACB(4), ACSL1(3), ACSL3(2), ADIPOR1(1), CAMKK2(1), CPT1C(1), G6PC2(1), IRS4(1), JAK1(1), JAK2(2), JAK3(3), LEPR(2), NFKB1(1), NFKB2(1), NFKBIE(2), PCK1(1), PPARA(1), PPARGC1A(2), PRKAA2(1), PRKAG2(3), PRKAG3(1), PRKCQ(2), PTPN11(1), STK11(2), TNFRSF1A(1), TYK2(2) 11522828 43 23 43 44 5 3 18 8 9 0 1.000 1.000 1.000 469 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP6V0A1(2), ATP6V0A4(1), ATP6V0C(1), ATP6V1A(1), ATP7B(3), COX4I1(1), COX6B1(1), COX7A1(1), NDUFA1(1), NDUFA10(2), NDUFB5(2), NDUFB7(1), NDUFS2(1), SDHA(1), SDHB(1), UQCRFS1(12) 5228982 32 23 21 15 3 0 11 15 3 0 0.963 1.000 1.000 470 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ARHGAP4(1), ARHGEF11(2), BTK(1), ITPR1(2), ITPR2(4), ITPR3(5), MYLK(2), MYLK2(2), PAK3(3), PAK4(1), PAK7(2), PIK3CA(1), PIK3R1(1), PITX2(3), ROCK1(2) 9656099 32 23 32 20 5 0 15 8 4 0 0.993 1.000 1.000 471 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ACTN1(2), BCAR1(1), BRAF(1), CDKN2A(2), DOCK1(2), ITGA10(2), ITGA2(1), ITGA3(2), ITGA4(1), ITGA6(1), ITGA9(1), MAPK1(1), MAPK8IP3(2), MYLK(2), MYLK2(2), P4HB(1), PAK3(3), PAK4(1), PAK7(2), PIK3CA(1), PIK3CB(1), PLCG1(3), ROCK1(2), SOS2(1), TLN1(2), TLN2(6), VASP(1), WAS(1), ZYX(1) 16951981 49 23 49 18 6 1 26 8 7 1 0.800 1.000 1.000 472 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 DNAJA3(1), JAK2(2), NFKB1(1), RB1(2), TNFRSF1A(1), TP53(18), USH1C(2), WT1(2) 2514174 29 23 29 14 4 1 8 3 12 1 0.967 1.000 1.000 473 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(1), AKR1D1(1), ARSD(2), CYP11B1(1), CYP11B2(1), HSD11B1(1), HSD17B1(5), HSD17B7(2), LCMT1(1), STS(1), UGT1A3(1), UGT1A5(2), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B15(2), UGT2B28(1), WBSCR22(1) 6815004 30 22 25 26 8 1 18 2 1 0 1.000 1.000 1.000 474 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL2(1), AREG(1), BRAF(1), CBL(1), CBLC(1), EGFR(3), ERBB3(1), ERBB4(5), GAB1(1), MAPK1(1), NCK2(1), NRG2(2), NRG3(2), PAK3(3), PAK4(1), PAK7(2), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PLCG1(3), PRKCG(1), SHC2(2), SHC3(1), SOS2(1), STAT5B(1) 14258983 43 22 42 19 10 3 14 8 8 0 0.944 1.000 1.000 475 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CLK2(1), COL2A1(1), CPSF1(2), CPSF3(1), CSTF2(1), DHX15(1), DHX38(1), DICER1(1), GIPC1(1), NCBP1(1), NXF1(1), PAPOLA(2), PRPF4B(1), PRPF8(2), PTBP2(1), RBM5(1), SF3B1(2), SNRPB2(1), SNRPE(1), SNRPN(1), SNURF(1), SRPK1(1), SRPK2(1), SRRM1(3), SUPT5H(1), U2AF1(1) 14559938 32 22 32 12 7 1 12 4 7 1 0.925 1.000 1.000 476 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(1), APAF1(1), BAG4(1), CASP8(1), DAXX(4), DFFA(1), FADD(2), GSN(1), LMNB1(1), LMNB2(2), MAP3K1(2), MDM2(2), NFKB1(1), NUMA1(1), PRKDC(3), RB1(2), SPTAN1(3), TNFRSF1A(1) 9626726 30 21 30 14 8 3 6 0 13 0 0.945 1.000 1.000 477 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP6(1), BMP8A(3), BMP8B(1), DHH(2), GLI2(2), GLI3(9), HHIP(2), LRP2(2), PRKACA(1), PRKACB(1), PTCH1(2), SHH(2), SMO(3), SUFU(1), WNT1(2), WNT10A(1), WNT16(1), WNT2(1), WNT2B(1), WNT3(1), WNT4(1), WNT6(1) 8249861 41 21 33 16 14 3 10 6 7 1 0.815 1.000 1.000 478 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 85 BRAF(1), DAXX(4), MAP2K3(2), MAP3K1(2), MAP3K12(1), MAP3K13(1), MAP3K3(1), MAP3K4(1), MAP3K8(1), MAP4K3(1), MAP4K4(1), MAPK1(1), MAPK11(1), MAPK7(2), MEF2C(2), MKNK1(1), NFKB1(1), RPS6KA1(1), RPS6KA4(2) 13569839 27 21 26 25 6 1 9 7 4 0 1.000 1.000 1.000 479 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(1), DHODH(3), DPYD(2), DPYS(2), NT5E(1), NT5M(1), NUDT2(1), POLD1(2), POLD2(1), POLE(3), POLG(1), POLQ(1), POLR2B(2), POLR2H(1), POLRMT(5), RRM2(1), UCK2(1) 7970231 29 21 25 11 5 7 9 4 4 0 0.850 1.000 1.000 480 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 BCR(2), BTK(1), CD19(2), CDKN2A(2), DAPP1(1), GAB1(1), ITPR1(2), ITPR2(4), ITPR3(5), PIK3CA(1), PITX2(3), PREX1(4), RPS6KA1(1), SYK(1), TEC(1), VAV1(3) 7642083 34 21 34 20 6 2 16 6 4 0 0.995 1.000 1.000 481 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 CKM(2), CKMT2(1), CPS1(3), DAO(1), EPRS(3), GLUD1(1), GLUD2(1), GOT1(1), GOT2(2), LAP3(1), NOS1(2), NOS3(4), PRODH(4), PYCRL(1), RARS2(2) 4978875 29 20 28 19 5 2 11 7 4 0 0.994 1.000 1.000 482 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 70 ADH6(1), ADH7(2), AKR1C3(1), AKR1C4(1), CYP2B6(3), CYP2C9(1), DHDH(1), EPHX1(1), GSTA2(1), GSTK1(1), GSTO2(1), GSTP1(1), GSTT2(2), MGST1(1), UGT1A3(1), UGT1A5(2), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B15(2), UGT2B28(1) 7872971 31 20 30 16 5 0 15 5 6 0 0.975 1.000 1.000 483 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACSL1(3), ACSL3(2), ANGPTL4(1), AQP7(4), CPT1C(1), CYP4A22(4), EHHADH(1), FABP2(1), FADS2(1), GK2(1), HMGCS2(1), PCK1(1), PPARA(1), SLC27A1(3), SLC27A5(1), SORBS1(1) 8901470 27 20 25 11 5 3 10 6 3 0 0.822 1.000 1.000 484 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH6(1), ADH7(2), AGK(1), AKR1A1(1), CEL(1), DGKB(1), DGKD(2), DGKH(1), DGKI(1), DGKZ(6), GK2(1), GPAM(2), LCT(1), PNLIP(3), PNLIPRP1(2), PNPLA3(2), PPAP2C(1) 8204393 29 19 27 13 4 0 12 8 5 0 0.914 1.000 1.000 485 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(2), AR(2), ESR1(1), HNF4A(1), NR1D1(1), NR1H2(2), NR2C2(1), NR2F1(3), NR4A2(2), NR5A1(2), NR5A2(1), PGR(1), PPARA(1), RARA(1), RORA(1), RORC(2), THRA(1), VDR(1) 5866536 26 19 26 19 3 2 8 5 7 1 1.000 1.000 1.000 486 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(1), AOC3(1), CKM(2), CKMT2(1), CPS1(3), DAO(1), GLUD1(1), GOT1(1), GOT2(2), MAOA(3), NOS1(2), NOS3(4), P4HB(1) 6107961 23 18 23 26 4 1 10 3 5 0 1.000 1.000 1.000 487 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 BCR(2), BTK(1), CD19(2), CR2(2), CSK(1), INPP5D(1), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), NFATC1(1), PIK3CA(1), PIK3R1(1), PPP3CB(1), SOS2(1), SYK(1), VAV1(3) 10092849 30 18 30 14 4 0 12 8 6 0 0.944 1.000 1.000 488 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(1), TP53(18), WT1(2) 967489 21 18 21 13 3 0 6 1 10 1 0.993 1.000 1.000 489 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ALG6(1), CCR3(1), CELSR1(3), CELSR2(1), CXCR3(2), EMR2(4), EMR3(1), FSHR(1), GPR133(1), GPR61(2), GPR84(2), GRM1(3), LGR6(2), LPHN2(1), LPHN3(3), SMO(3), SSTR2(1), TAAR5(3) 9163804 35 17 34 17 6 2 17 8 2 0 0.883 1.000 1.000 490 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 INPP4A(2), INPP5B(1), IPMK(1), OCRL(1), PI4KA(4), PIK3C3(1), PIK3CA(1), PIK3CB(1), PIP4K2B(1), PIP5K1C(1), PLCB1(3), PLCB3(1), PLCB4(1), PLCE1(2), PLCG1(3), SYNJ1(1) 10340170 25 17 25 26 6 1 10 6 2 0 1.000 1.000 1.000 491 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 ERCC3(1), POLR1A(1), POLR2B(2), POLR2H(1), TAF5(12) 4741344 17 17 6 12 0 0 3 12 2 0 0.998 1.000 1.000 492 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(1), FLNA(3), FLNC(1), MYH2(2), MYLK(2), MYLK2(2), PAK3(3), PAK4(1), PAK7(2), ROCK1(2), VASP(1) 6599267 20 17 20 12 3 2 8 4 3 0 0.946 1.000 1.000 493 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(1), CD3D(1), CSK(1), CTLA4(2), ITK(1), LAT(1), LCK(1), MAPK1(1), NFKB1(1), NFKB2(1), NFKBIE(2), PAK3(3), PAK4(1), PAK7(2), PLCG1(3), RASGRP1(2), SOS2(1), VAV1(3), ZAP70(1) 7855491 29 17 29 33 5 1 13 3 7 0 1.000 1.000 1.000 494 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(2), GAA(1), HK2(3), HK3(3), MGAM(4), PYGL(1), SI(5), UGT1A3(1), UGT1A5(2), UGT2B15(2) 7870820 24 17 24 12 2 0 12 6 4 0 0.946 1.000 1.000 495 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 CREBBP(1), EP300(2), ERCC3(1), ESR1(1), GRIP1(3), HDAC1(1), HDAC2(1), HDAC4(1), HDAC6(2), MEF2C(2), NCOR2(4), NRIP1(3), PELP1(1) 6521150 23 16 23 22 0 0 12 6 5 0 1.000 1.000 1.000 496 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP5(1), ACPP(1), ALPI(1), ALPP(1), ALPPL2(8), CYP2A6(1), CYP2B6(3), CYP2C9(1), CYP2J2(1), CYP4B1(1), PON1(1) 4022990 20 16 14 9 1 9 8 2 0 0 0.817 1.000 1.000 497 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(1), AGPS(1), CDIPT(1), CHAT(1), CHKB(1), DGKB(1), DGKD(2), DGKH(1), DGKZ(6), GNPAT(1), PCYT1B(1), PEMT(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLCG1(3), PPAP2C(1) 7076651 29 16 27 11 5 1 13 6 4 0 0.782 1.000 1.000 498 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ENO2(1), ENO3(1), GOT1(1), GOT2(2), HK2(3), HK3(3), LDHA(3), MDH2(1), PC(1), PCK1(1), PDHB(1), PFKL(2), PGAM1(1), PGK2(3) 5761728 24 16 24 10 5 1 10 6 2 0 0.776 1.000 1.000 499 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 FUK(3), GMPPB(1), HK2(3), HK3(3), KHK(2), LHPP(2), MTMR1(1), MTMR2(1), PFKL(2) 5226583 18 16 17 11 5 3 6 2 2 0 0.943 1.000 1.000 500 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 66 ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0C(1), ATP6V0D2(1), ATP6V1A(1), ATP6V1E2(1), CSK(1), CXCL1(1), EGFR(3), F11R(2), GIT1(1), MAPK11(1), NFKB1(1), NFKB2(1), NOD1(1), PLCG1(3), PTPN11(1), PTPRZ1(2), TCIRG1(1), TJP1(1) 9721091 29 16 29 29 5 0 12 4 8 0 1.000 1.000 1.000 501 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 BRAF(1), EGFR(3), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), PIK3CB(1), PITX2(3), PLCB1(3), PLCB3(1), PLCB4(1), SOS2(1) 8020097 26 16 26 15 6 1 10 8 1 0 0.965 1.000 1.000 502 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 27 ITPR1(2), ITPR2(4), ITPR3(5), NFKB1(1), NFKB2(1), NFKBIE(2), PHKA2(2), PIK3CB(1), PITX2(3), PLD2(1) 6322591 22 16 22 30 3 1 13 5 0 0 1.000 1.000 1.000 503 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH6(1), ADH7(2), AKR1A1(1), CEL(1), DGKB(1), DGKD(2), DGKH(1), DGKZ(6), LCT(1), PNLIP(3), PNLIPRP1(2), PPAP2C(1) 6767103 22 15 20 10 3 0 9 7 3 0 0.925 1.000 1.000 504 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS2(1), ADH6(1), ADH7(2), AKR1A1(1), ENO2(1), ENO3(1), G6PC2(1), HK2(3), HK3(3), LDHA(3), PDHB(1), PFKL(2), PGAM1(1), PGK2(3) 7949915 24 15 24 15 4 1 8 8 3 0 0.987 1.000 1.000 505 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 KDR(1), MAPK1(1), MAPK11(1), NFATC1(1), NOS3(4), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLCG1(3), PPP3CB(1), PRKCG(1), PTGS2(1), SH2D2A(1), SHC2(2), SPHK1(2), SPHK2(2) 10029602 35 15 35 12 6 2 13 8 6 0 0.774 1.000 1.000 506 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ADCY1(1), GNAS(5), GNB1(2), MAPK1(1), PIN1(1), PRKACB(1), PRKAR1A(7), RPS6KA1(1) 2869292 19 15 18 11 2 0 4 3 10 0 0.998 1.000 1.000 507 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(8), B3GALT4(1), CDR1(1), DGKI(1), RPL12(1), RPL13A(1), RPL14(1), RPL22(1), RPL39(1), RPS21(1), RPS24(1), RPS3(1), RPS6KA1(1), RPS6KA6(1), RPS9(1), SLC36A2(1), UBB(1) 7078619 24 15 24 29 3 0 14 4 3 0 1.000 1.000 1.000 508 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 APC(4), ITPR1(2), ITPR2(4), ITPR3(5), MAPK1(1), PITX2(3), PTX3(1), RYR1(4) 6422087 24 15 24 14 4 0 11 7 2 0 0.965 1.000 1.000 509 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(1), GNAS(5), MAPK1(1), PIK3CA(1), PIK3R1(1), PRKACB(1), PRKAR1A(7), RPS6KA1(1) 4020793 18 14 17 12 1 0 3 4 10 0 0.999 1.000 1.000 510 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASDHPPT(1), DLST(1), DOT1L(2), ECHS1(2), EHHADH(1), EHMT1(3), EHMT2(1), HADH(1), HADHA(1), HSD17B4(3), NSD1(3), OGDHL(1), PIPOX(1), PLOD3(2), SETD1A(1), SETDB1(1), SHMT2(1) 7928148 26 14 26 11 4 1 13 2 6 0 0.853 1.000 1.000 511 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 73 BTK(1), FCER1A(2), IL3(1), INPP5D(1), LAT(1), MAP2K3(2), MAPK1(1), MAPK11(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PLA2G1B(1), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLCG1(3), SOS2(1), SYK(1), VAV1(3), VAV2(1), VAV3(3) 9780118 36 14 36 14 5 1 12 9 9 0 0.908 1.000 1.000 512 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(5), CASP8(1), INSR(1), ITCH(1), MAGI1(2), MAGI2(4), RERE(2), WWP1(1), WWP2(1) 3231733 18 14 15 10 2 0 13 2 1 0 0.967 1.000 1.000 513 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 BCL2L1(2), CDKN2A(2), ERBB4(5), GAB1(1), IGFBP1(1), IRS4(1), PAK3(3), PAK4(1), PAK7(2), PARD3(1), PIK3CA(1), PREX1(4), RPS6KA1(1), SOS2(1), TSC2(1) 10492334 27 14 27 30 4 2 12 3 6 0 1.000 1.000 1.000 514 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 BRAF(1), CREBBP(1), EGR1(2), EGR2(1), EGR3(1), EGR4(3), MAP1B(2), MAPK1(1), MAPK8IP3(2), NTRK1(1), PIK3C2G(1), PIK3CA(1), PIK3R1(1), PTPN11(1), TH(3) 7218048 22 14 22 10 5 0 9 6 2 0 0.870 1.000 1.000 515 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(3), GNAS(5), GNB1(2), IGF1R(1), MAPK1(1), MKNK1(1), NGFR(2), PDGFRA(1), RPS6KA1(1) 4630830 17 13 17 14 7 0 5 3 2 0 0.998 1.000 1.000 516 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH6(1), ADH7(2), AKR1A1(1), ENO2(1), ENO3(1), HK2(3), HK3(3), LDHA(3), PDHB(1), PGAM1(1) 6649636 17 13 17 12 3 1 6 5 2 0 0.986 1.000 1.000 517 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH6(1), ADH7(2), AKR1A1(1), ENO2(1), ENO3(1), HK2(3), HK3(3), LDHA(3), PDHB(1), PGAM1(1) 6649636 17 13 17 12 3 1 6 5 2 0 0.986 1.000 1.000 518 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 DHCR24(2), DHCR7(1), FDFT1(1), HMGCR(1), HSD17B7(2), IDI1(5), NSDHL(1), SQLE(2) 2698903 15 13 12 20 1 1 10 1 2 0 1.000 1.000 1.000 519 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP4A(2), OCRL(1), PIK3C2G(1), PIK3CA(1), PIK3CB(1), PLCB1(3), PLCB3(1), PLCB4(1), PLCG1(3) 6231922 14 13 14 18 3 1 5 5 0 0 1.000 1.000 1.000 520 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 FPR1(2), GNB1(2), MAP2K3(2), MAP3K1(2), MAPK1(1), NFATC1(1), NFKB1(1), PIK3C2G(1), PLCB1(3), PPP3CB(1) 5343247 16 12 16 7 2 0 11 3 0 0 0.824 1.000 1.000 521 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(2), ARSD(2), DEGS2(1), GAL3ST1(1), GALC(1), LCT(1), PPAP2C(1), SGPP1(1), SMPD4(1), SPHK1(2), SPHK2(2), SPTLC1(1), SPTLC2(1) 4904800 17 12 17 10 3 0 11 1 2 0 0.944 1.000 1.000 522 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 63 BTK(1), CARD11(3), CD19(2), CR2(2), INPP5D(1), NFATC1(1), NFKB1(1), NFKB2(1), NFKBIE(2), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PPP3CB(1), PTPN6(1), SYK(1), VAV1(3), VAV2(1), VAV3(3) 10267179 31 12 31 36 3 1 14 6 7 0 1.000 1.000 1.000 523 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ARHGAP4(1), ARHGAP6(2), ARHGEF1(1), ARHGEF11(2), ARHGEF5(2), ARPC2(1), GSN(1), MYLK(2), ROCK1(2), TLN1(2) 6410134 16 12 16 12 3 1 7 3 2 0 0.992 1.000 1.000 524 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 BRD4(1), CBL(1), CDKN2A(2), IGFBP1(1), IRS4(1), LNPEP(1), MAPK1(1), PARD3(1), PIK3CA(1), PIK3R1(1), PPYR1(3), RPS6KA1(1), SORBS1(1), SOS2(1) 8012878 17 12 17 24 3 1 8 2 3 0 1.000 1.000 1.000 525 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 35 ARHGEF11(2), LPA(1), MAP3K1(2), NFKB1(1), NFKB2(1), NFKBIE(2), PHKA2(2), PIK3CB(1), PLD2(1), ROCK1(2), SERPINA4(1), SRF(1), TBXA2R(1) 6701222 18 12 18 32 4 1 11 2 0 0 1.000 1.000 1.000 526 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 MAPK1(1), MAPK7(2), MEF2C(2), NTRK1(1), PIK3CA(1), PIK3R1(1), PLCG1(3), RPS6KA1(1) 2716219 12 11 11 10 2 0 7 3 0 0 0.996 1.000 1.000 527 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 BRAF(1), MAPK1(1), PIK3CA(1), PIK3CB(1), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(1), PRKAA2(1), RPS6KA1(1), RPS6KA6(1), STK11(2), TSC2(1), ULK1(1), ULK2(1), ULK3(1), VEGFB(1) 7379172 19 11 19 15 0 2 7 5 5 0 1.000 1.000 1.000 528 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 DAXX(4), MAP3K1(2), MEF2C(2), MKNK1(1), PLA2G4A(3) 5110395 12 11 12 11 2 1 4 2 3 0 0.999 1.000 1.000 529 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 BCR(2), BTK(1), CD19(2), CSK(1), MAPK1(1), NFKB1(1), NFKB2(1), NFKBIE(2), PIK3CA(1), PIK3R1(1), SERPINA4(1), SOS2(1), SYK(1), VAV1(3) 7283022 19 11 19 33 2 0 10 3 4 0 1.000 1.000 1.000 530 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 28 BAG4(1), CASP8(1), FADD(2), MAP3K3(1), NFKB1(1), NFKB2(1), NFKBIE(2), NR2C2(1), TNFRSF1A(1) 3813055 11 11 11 28 2 1 6 0 2 0 1.000 1.000 1.000 531 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(1), AKR1D1(1), ARSD(2), CYP11B1(1), CYP11B2(1), HSD11B1(1), STS(1), UGT1A3(1), UGT1A5(2), UGT2B15(2) 3695827 13 10 13 21 2 0 8 2 1 0 1.000 1.000 1.000 532 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 EGFR(3), JAK1(1), MAP3K1(2), PIK3CA(1), PIK3R1(1), PLCG1(3), SRF(1) 5087679 12 10 12 6 6 0 5 1 0 0 0.847 1.000 1.000 533 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 29 CABIN1(1), IGF1R(1), INSR(1), MAPK7(2), MEF2C(2), NFATC1(1), PIK3CA(1), PIK3R1(1), PPP3CB(1) 4781674 11 10 10 6 2 0 6 3 0 0 0.877 1.000 1.000 534 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 CTH(1), DNMT3B(1), MARS(1), MARS2(1), MTAP(1), MTFMT(4), MTR(1), SRM(1) 2870791 11 10 9 16 2 1 1 6 1 0 1.000 1.000 1.000 535 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 BCR(2), MAP3K1(2), MAPK1(1), MAPK8IP3(2), PAPPA(5), RPS6KA1(1), SYK(1), VAV1(3), VAV2(1), VAV3(3) 4424463 21 10 21 13 3 0 12 2 4 0 0.991 1.000 1.000 536 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 GNB1(2), JAK2(2), MAPK1(1), MYLK(2), PLCG1(3) 5776211 10 9 10 7 2 0 5 3 0 0 0.972 1.000 1.000 537 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 AGMAT(1), ALDH18A1(2), AOC3(1), CPS1(3), MAOA(3), SAT1(2), SRM(1) 4078215 13 9 13 20 1 0 7 0 5 0 1.000 1.000 1.000 538 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IL1RN(2), IRAK1(2), IRAK2(2), MAP2K3(2), MAP3K1(2), NFKB1(1) 4046748 11 9 10 8 3 0 5 3 0 0 0.981 1.000 1.000 539 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 31 ADRA2A(2), ADRA2C(4), CHRM5(1), DRD3(1), DRD5(1), HTR2A(1), HTR2C(1), HTR5A(3), HTR6(1) 3518070 15 9 14 10 3 2 5 3 2 0 0.941 1.000 1.000 540 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGEF1(1), GNB1(2), MYLK(2), PLCB1(3), ROCK1(2) 2790669 10 9 10 5 1 0 8 1 0 0 0.882 1.000 1.000 541 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(1), ARHGEF1(1), GNB1(2), PIK3CA(1), PIK3R1(1), PLCB1(3), ROCK1(2) 3489296 11 9 11 6 1 0 7 3 0 0 0.925 1.000 1.000 542 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 28 ANXA1(1), ANXA5(1), EDNRB(1), HSD11B1(1), PLA2G4A(3), PTGDS(1), PTGER4(1), PTGIR(1), PTGS1(1), PTGS2(1) 2850106 12 9 12 29 1 0 6 3 2 0 1.000 1.000 1.000 543 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 INSR(1), JAK2(2), MAPK1(1), PIK3CA(1), PIK3R1(1), PLCG1(3), PTPN6(1), RPS6KA1(1), SRF(1), STAT5B(1) 4517348 13 8 13 14 4 0 3 4 2 0 1.000 1.000 1.000 544 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ADH6(1), ADH7(2), AKR1C4(1), AKR1D1(1), BAAT(1), CEL(1), HADHB(1), SLC27A5(1), SOAT2(1) 4376885 10 8 10 29 3 0 4 2 1 0 1.000 1.000 1.000 545 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 AOC3(1), DPYD(2), DPYS(2), ECHS1(2), EHHADH(1), HADHA(1), SRM(1) 3659600 10 8 10 13 2 0 5 0 3 0 1.000 1.000 1.000 546 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 JAK1(1), MAP3K1(2), PDGFRA(1), PIK3CA(1), PIK3R1(1), PLCG1(3), SRF(1) 4754969 10 8 10 7 4 0 4 2 0 0 0.956 1.000 1.000 547 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 IL4R(1), JAK1(1), JAK3(3), MAPK1(1), PIK3CA(1), PIK3R1(1), SOS2(1), STAT6(1) 4977591 10 8 10 11 1 1 3 4 1 0 0.999 1.000 1.000 548 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 DUSP1(1), MAP2K3(2), MAP3K4(1), MAPK1(1), MAPK11(1), MKNK1(1), MYEF2(1), NFKB1(1), NR2C2(1), SRF(1) 4673938 11 8 11 11 3 0 5 3 0 0 0.998 1.000 1.000 549 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(1), ARFGEF2(2), CLTB(3), COPA(1), GPLD1(1) 2212391 8 7 8 5 2 1 4 1 0 0 0.911 1.000 1.000 550 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 EGFR(3), MAP3K1(2), MAPK1(1), MEF2C(2) 4654717 8 7 8 6 3 0 3 2 0 0 0.944 1.000 1.000 551 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ADH6(1), ADH7(2), AKR1C4(1), AKR1D1(1), BAAT(1), CEL(1), HADHB(1), SOAT2(1) 3161818 9 7 9 24 3 0 3 2 1 0 1.000 1.000 1.000 552 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(1), ETS2(1), HDAC2(1), NCOR2(4), RBL1(1), SIN3B(2) 3711836 10 7 10 10 3 0 3 3 1 0 0.996 1.000 1.000 553 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 GABRA1(2), GABRA2(2), GABRA6(2), UBQLN1(1) 1648217 7 7 7 4 0 0 6 1 0 0 0.912 1.000 1.000 554 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACO1(1), CS(1), DLST(1), FH(1), IDH3G(1), MDH2(1), OGDHL(1), PC(1), PCK1(1), SDHA(1), SDHB(1), SDHD(1) 4076526 12 7 12 8 1 1 7 3 0 0 0.954 1.000 1.000 555 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 G6PD(2), PFKL(2), PRPS1L1(1), RPIA(1), TKTL2(3) 3351359 9 7 8 22 3 2 2 2 0 0 1.000 1.000 1.000 556 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT2(1), B4GALT7(1), CHPF(2), CHST11(1), CHST13(3), CHST3(1), DSE(2), XYLT1(1) 1954195 12 7 11 7 1 3 4 4 0 0 0.907 1.000 1.000 557 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 CS(1), DLST(1), FH(1), IDH3G(1), MDH2(1), PC(1), PDHB(1), PDK3(1), SDHA(1), SDHB(1), SDHD(1) 3897773 11 7 11 6 0 1 7 3 0 0 0.902 1.000 1.000 558 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 NGFR(2), PIK3CA(1), PIK3R1(1), PLCG1(3) 2593175 7 7 7 4 4 0 2 1 0 0 0.880 1.000 1.000 559 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(1), NCOA1(2), NCOA2(1), NCOR2(4), RARA(1) 3459263 9 7 9 18 0 0 4 3 2 0 1.000 1.000 1.000 560 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(1), PDE1A(2), PLCB1(3), TRH(1), VIP(1) 1512421 8 7 8 8 1 1 3 3 0 0 0.994 1.000 1.000 561 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 33 DUSP1(1), MAPK1(1), MAPK11(1), MAPK8IP3(2), NFKB1(1), NFKB2(1), NFKBIE(2), PIK3CA(1), PIK3R1(1) 4851854 11 7 11 26 0 0 8 3 0 0 1.000 1.000 1.000 562 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BRAF(1), DUSP6(1), MAP3K8(1), MAPK1(1), MKNK1(1), NFKB1(1), RPS6KA1(1), SOS2(1) 4108355 8 7 8 13 2 0 2 3 1 0 1.000 1.000 1.000 563 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(1), BTK(1), CDKN2A(2), DAPP1(1), IARS(1), IGFBP1(1), INPP5D(1), PIK3CA(1), RPS6KA1(1), SOS2(1), TEC(1) 4858976 12 7 12 13 1 0 5 3 3 0 1.000 1.000 1.000 564 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 HLA-DRB1(3), IL18R1(2), IL2(1), IL4R(1) 1738503 7 7 7 4 0 1 5 1 0 0 0.889 1.000 1.000 565 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ALDH18A1(2), CKM(2), CKMT2(1), CPS1(3), GLUD1(1) 2451275 9 7 9 17 1 0 4 2 2 0 1.000 1.000 1.000 566 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(2), EDNRB(1), EGFR(3), NFKB1(1), PLCG1(3) 2789316 10 6 10 5 5 1 4 0 0 0 0.786 1.000 1.000 567 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(1), CSF1R(1), EGFR(3), PDGFRA(1) 2658383 6 6 6 6 3 1 1 1 0 0 0.974 1.000 1.000 568 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPS7(1), RPL12(1), RPL13A(1), RPL14(1), RPL39(1), RPS21(1), RPS24(1), RPS3(1), RPS9(1) 2972477 9 6 9 18 1 0 5 2 1 0 1.000 1.000 1.000 569 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(1), JAK2(2), JAK3(3), PTPRU(1) 1927977 7 6 7 4 1 0 3 3 0 0 0.895 1.000 1.000 570 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 25 MAP2K3(2), MAP3K1(2), NFKB1(1), TANK(1), TNFRSF1A(1) 3355355 7 6 7 5 1 0 5 1 0 0 0.957 1.000 1.000 571 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 NTRK1(1), PIK3CA(1), PIK3R1(1), PLCG1(3) 2125976 6 6 6 4 2 0 3 1 0 0 0.936 1.000 1.000 572 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 NFATC1(1), PLCG1(3), PPP3CB(1) 2779525 5 5 5 3 2 0 3 0 0 0 0.850 1.000 1.000 573 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ADH6(1), ADH7(2), DHRS3(1), ESCO2(1), PNPLA3(2) 3336521 7 5 7 10 1 0 1 3 2 0 1.000 1.000 1.000 574 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 IGF1R(1), PIK3CA(1), PIK3R1(1), PTPN11(1), SRF(1) 3356010 5 5 5 5 2 0 1 2 0 0 0.984 1.000 1.000 575 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 HLA-DRB1(3), IL2(1), IL3(1) 1869697 5 5 5 8 0 0 4 1 0 0 0.999 1.000 1.000 576 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 INSR(1), PIK3CA(1), PIK3R1(1), PTPN11(1), SRF(1) 3461742 5 5 5 5 2 0 1 2 0 0 0.986 1.000 1.000 577 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 MST1(5) 892137 5 5 4 5 1 0 3 1 0 0 0.976 1.000 1.000 578 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 14 MTNR1A(2), MTNR1B(2), PTGER4(1), PTGIR(1), TBXA2R(1) 1574925 7 5 6 24 1 0 4 2 0 0 1.000 1.000 1.000 579 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(1), EGFR(3), MAPK1(1) 3402300 5 5 5 3 2 1 1 1 0 0 0.897 1.000 1.000 580 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 EPHB1(1), L1CAM(1), SELP(2) 2136314 4 4 4 3 0 0 3 1 0 0 0.950 1.000 1.000 581 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP2A6(1), XDH(3) 1092359 4 4 4 4 0 0 4 0 0 0 0.981 1.000 1.000 582 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 IGF1R(1), MAPK1(1), PIK3CA(1), PIK3R1(1) 2550264 4 4 4 4 1 0 1 2 0 0 0.982 1.000 1.000 583 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(2), PLCG1(3) 921760 5 4 5 5 4 0 1 0 0 0 0.955 1.000 1.000 584 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSS(1), IMPDH1(1), OAZ1(1), POLD1(2), POLG(1), SRM(1) 1800831 7 4 7 10 1 0 5 0 1 0 1.000 1.000 1.000 585 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 G6PD(2), PRPS1L1(1), RPIA(1) 2761858 4 4 4 21 1 1 1 1 0 0 1.000 1.000 1.000 586 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 BCAR1(1), MAPK1(1), PIK3CA(1), PIK3R1(1) 2623376 4 4 4 3 0 0 2 2 0 0 0.952 1.000 1.000 587 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 FCGR3A(3), IL6R(1), TNFRSF1A(1) 1913999 5 4 5 5 0 0 5 0 0 0 0.977 1.000 1.000 588 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 IGF1R(1), PIK3CA(1), PIK3R1(1) 1799971 3 3 3 9 1 0 1 1 0 0 1.000 1.000 1.000 589 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 MEF2C(2), PPARA(1), PPP3CB(1) 2914713 4 3 4 4 0 0 2 2 0 0 0.972 1.000 1.000 590 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD8A(1), EPO(1), IL2(1), IL3(1) 856121 4 3 4 3 0 1 3 0 0 0 0.882 1.000 1.000 591 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IL2(1), IL3(1) 1342021 2 2 2 2 0 0 2 0 0 0 0.952 1.000 1.000 592 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 EPO(1), IL3(1) 1168926 2 2 2 3 0 0 2 0 0 0 0.990 1.000 1.000 593 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 CS(1), FH(1), SDHA(1) 1287672 3 2 3 3 0 0 3 0 0 0 0.955 1.000 1.000 594 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 CS(1), PC(1) 1270925 2 2 2 2 0 0 1 1 0 0 0.946 1.000 1.000 595 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CSK(1), PTPRA(1) 1275506 2 2 2 2 0 0 2 0 0 0 0.942 1.000 1.000 596 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 UBE2S(1), UBE3A(1) 1422278 2 2 2 2 0 0 1 1 0 0 0.969 1.000 1.000 597 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(1) 736961 1 1 1 3 0 0 1 0 0 0 0.995 1.000 1.000 598 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 IL2(1) 416620 1 1 1 2 0 0 1 0 0 0 0.991 1.000 1.000 599 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 LDLR(1) 720336 1 1 1 3 0 0 1 0 0 0 0.994 1.000 1.000 600 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 P2RY2(2) 788822 2 1 2 3 2 0 0 0 0 0 0.951 1.000 1.000 601 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 TGM2(1) 697721 1 1 1 4 1 0 0 0 0 0 0.996 1.000 1.000 602 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 NEK1(1) 1032923 1 1 1 3 0 0 1 0 0 0 0.997 1.000 1.000 603 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(1) 787135 1 1 1 2 0 0 1 0 0 0 0.985 1.000 1.000 604 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 1090041 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 605 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 1090041 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 606 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 433444 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 607 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 1186824 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 608 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 1171540 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 609 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 240059 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 610 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 652482 0 0 0 2 0 0 0 0 0 0 1.000 1.000 1.000 611 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 68167 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 612 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 294059 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 613 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 657612 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 614 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 519909 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 615 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 544114 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 616 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 813718 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000