Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
HIF-1-alpha transcription factor network	14.0	1079.0	76.0	-0.312	0.015	1000.0	-1000.0	-0.054	-1000.0
Glypican 2 network	13.0	54.0	4.0	-0.103	-0.006	1000.0	-1000.0	-0.009	-1000.0
Signaling events mediated by the Hedgehog family	10.0	546.0	52.0	-0.126	0.104	1000.0	-1000.0	-0.025	-1000.0
Ephrin A  reverse signaling	10.0	76.0	7.0	-0.11	-0.0	1000.0	-1000.0	-0.008	-1000.0
Wnt signaling	10.0	71.0	7.0	-0.112	-0.024	1000.0	-1000.0	-0.015	-1000.0
FOXA2 and FOXA3 transcription factor networks	9.0	422.0	46.0	-0.375	0.011	1000.0	-1000.0	-0.077	-1000.0
S1P4 pathway	9.0	231.0	25.0	-0.192	0.015	1000.0	-1000.0	-0.016	-1000.0
Glypican 1 network	8.0	385.0	48.0	-0.181	0.014	1000.0	-1000.0	-0.014	-1000.0
Signaling events regulated by Ret tyrosine kinase	8.0	700.0	82.0	-0.111	0.009	1000.0	-1000.0	-0.044	-1000.0
S1P5 pathway	8.0	141.0	17.0	-0.192	0.068	1000.0	-1000.0	-0.015	-1000.0
Osteopontin-mediated events	7.0	276.0	38.0	-0.071	0.009	1000.0	-1000.0	-0.04	-1000.0
Noncanonical Wnt signaling pathway	7.0	205.0	26.0	-0.112	0.009	1000.0	-1000.0	-0.025	-1000.0
Thromboxane A2 receptor signaling	7.0	794.0	105.0	-0.125	0.036	1000.0	-1000.0	-0.039	-1000.0
Fc-epsilon receptor I signaling in mast cells	7.0	695.0	97.0	-0.102	0.024	1000.0	-1000.0	-0.041	-1000.0
Ephrin B reverse signaling	7.0	354.0	48.0	-0.09	0.05	1000.0	-1000.0	-0.028	-1000.0
S1P3 pathway	7.0	310.0	42.0	-0.192	0.016	1000.0	-1000.0	-0.033	-1000.0
FOXM1 transcription factor network	7.0	359.0	51.0	-0.198	0.019	1000.0	-1000.0	-0.14	-1000.0
BMP receptor signaling	6.0	538.0	81.0	-0.163	0.018	1000.0	-1000.0	-0.049	-1000.0
EPO signaling pathway	6.0	381.0	55.0	-0.057	0.009	1000.0	-1000.0	-0.036	-1000.0
Signaling mediated by p38-alpha and p38-beta	6.0	286.0	44.0	-0.132	0.009	1000.0	-1000.0	-0.019	-1000.0
TCR signaling in naïve CD8+ T cells	6.0	611.0	93.0	-0.094	0.013	1000.0	-1000.0	-0.043	-1000.0
EPHB forward signaling	6.0	589.0	85.0	-0.111	0.062	1000.0	-1000.0	-0.046	-1000.0
Nongenotropic Androgen signaling	6.0	329.0	52.0	-0.192	0.022	1000.0	-1000.0	-0.027	-1000.0
EGFR-dependent Endothelin signaling events	6.0	131.0	21.0	-0.076	0.013	1000.0	-1000.0	-0.022	-1000.0
IGF1 pathway	6.0	355.0	57.0	-0.061	0.019	1000.0	-1000.0	-0.041	-1000.0
Plasma membrane estrogen receptor signaling	6.0	524.0	86.0	-0.213	0.067	1000.0	-1000.0	-0.041	-1000.0
Class IB PI3K non-lipid kinase events	6.0	18.0	3.0	-0.044	-1000.0	1000.0	-1000.0	-0.004	-1000.0
Ras signaling in the CD4+ TCR pathway	6.0	106.0	17.0	-0.08	0.017	1000.0	-1000.0	-0.021	-1000.0
IL12-mediated signaling events	5.0	490.0	87.0	-0.15	0.009	1000.0	-1000.0	-0.092	-1000.0
Endothelins	5.0	515.0	96.0	-0.204	0.016	1000.0	-1000.0	-0.045	-1000.0
S1P1 pathway	5.0	187.0	36.0	-0.193	0.011	1000.0	-1000.0	-0.032	-1000.0
Signaling mediated by p38-gamma and p38-delta	5.0	78.0	15.0	-0.072	0.011	1000.0	-1000.0	-0.016	-1000.0
LPA receptor mediated events	5.0	557.0	102.0	-0.137	0.014	1000.0	-1000.0	-0.045	-1000.0
IL6-mediated signaling events	5.0	382.0	75.0	-0.246	0.031	1000.0	-1000.0	-0.039	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	5.0	392.0	68.0	-0.141	0.041	1000.0	-1000.0	-0.079	-1000.0
BCR signaling pathway	5.0	509.0	99.0	-0.103	0.01	1000.0	-1000.0	-0.044	-1000.0
Aurora B signaling	5.0	379.0	67.0	-0.114	0.009	1000.0	-1000.0	-0.037	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	4.0	148.0	34.0	-0.039	0.009	1000.0	-1000.0	-0.017	-1000.0
Syndecan-1-mediated signaling events	4.0	148.0	34.0	-0.066	0.009	1000.0	-1000.0	-0.029	-1000.0
p75(NTR)-mediated signaling	4.0	560.0	125.0	-0.169	0.027	1000.0	-1000.0	-0.045	-1000.0
IL4-mediated signaling events	4.0	367.0	91.0	-0.305	0.124	1000.0	-1000.0	-0.118	-1000.0
PDGFR-alpha signaling pathway	4.0	208.0	44.0	-0.068	0.015	1000.0	-1000.0	-0.029	-1000.0
amb2 Integrin signaling	4.0	367.0	82.0	-0.077	0.012	1000.0	-1000.0	-0.033	-1000.0
Reelin signaling pathway	4.0	254.0	56.0	-0.076	0.02	1000.0	-1000.0	-0.031	-1000.0
Integrins in angiogenesis	4.0	412.0	84.0	-0.117	0.013	1000.0	-1000.0	-0.036	-1000.0
Syndecan-4-mediated signaling events	4.0	270.0	67.0	-0.103	0.012	1000.0	-1000.0	-0.036	-1000.0
IL23-mediated signaling events	4.0	291.0	60.0	-0.154	0.014	1000.0	-1000.0	-0.125	-1000.0
Angiopoietin receptor Tie2-mediated signaling	4.0	382.0	88.0	-0.186	0.012	1000.0	-1000.0	-0.067	-1000.0
ErbB2/ErbB3 signaling events	3.0	250.0	65.0	-0.066	0.02	1000.0	-1000.0	-0.036	-1000.0
Caspase cascade in apoptosis	3.0	264.0	74.0	-0.031	0.026	1000.0	-1000.0	-0.02	-1000.0
Coregulation of Androgen receptor activity	3.0	277.0	76.0	-0.151	0.034	1000.0	-1000.0	-0.02	-1000.0
Sphingosine 1-phosphate (S1P) pathway	3.0	86.0	28.0	-0.192	0.023	1000.0	-1000.0	-0.015	-1000.0
Syndecan-2-mediated signaling events	3.0	221.0	69.0	-0.04	0.011	1000.0	-1000.0	-0.013	-1000.0
Arf6 signaling events	3.0	213.0	62.0	-0.098	0.021	1000.0	-1000.0	-0.025	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	210.0	65.0	-0.193	0.051	1000.0	-1000.0	-0.035	-1000.0
Aurora C signaling	3.0	23.0	7.0	-0.065	0.0	1000.0	-1000.0	-0.02	-1000.0
Nectin adhesion pathway	3.0	206.0	63.0	-0.047	0.014	1000.0	-1000.0	-0.042	-1000.0
Glucocorticoid receptor regulatory network	3.0	350.0	114.0	-0.15	0.035	1000.0	-1000.0	-0.042	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	3.0	147.0	37.0	-0.077	0.017	1000.0	-1000.0	-0.022	-1000.0
HIF-2-alpha transcription factor network	3.0	137.0	43.0	-0.067	0.018	1000.0	-1000.0	-0.051	-1000.0
Retinoic acid receptors-mediated signaling	3.0	174.0	58.0	-0.043	0.018	1000.0	-1000.0	-0.033	-1000.0
Syndecan-3-mediated signaling events	3.0	133.0	35.0	-0.125	0.027	1000.0	-1000.0	-0.017	-1000.0
IL2 signaling events mediated by STAT5	3.0	72.0	22.0	-0.077	0.009	1000.0	-1000.0	-0.026	-1000.0
TCGA08_retinoblastoma	3.0	30.0	8.0	-0.016	0.007	1000.0	-1000.0	-0.007	-1000.0
Visual signal transduction: Rods	3.0	186.0	52.0	-0.075	0.009	1000.0	-1000.0	-0.036	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	3.0	276.0	78.0	-0.062	0.021	1000.0	-1000.0	-0.044	-1000.0
Visual signal transduction: Cones	2.0	94.0	38.0	-0.058	0.012	1000.0	-1000.0	-0.017	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	2.0	156.0	54.0	-0.076	0.017	1000.0	-1000.0	-0.043	-1000.0
JNK signaling in the CD4+ TCR pathway	2.0	44.0	17.0	-0.039	0.014	1000.0	-1000.0	-0.02	-1000.0
a4b1 and a4b7 Integrin signaling	2.0	10.0	5.0	-0.012	0.002	1000.0	-1000.0	-0.008	-1000.0
Cellular roles of Anthrax toxin	2.0	80.0	39.0	-0.05	0.01	1000.0	-1000.0	-0.02	-1000.0
Signaling events mediated by PTP1B	2.0	225.0	76.0	-0.143	0.014	1000.0	-1000.0	-0.044	-1000.0
PLK1 signaling events	2.0	231.0	85.0	-0.054	0.014	1000.0	-1000.0	-0.029	-1000.0
TRAIL signaling pathway	2.0	136.0	48.0	-0.05	0.017	1000.0	-1000.0	-0.03	-1000.0
IL1-mediated signaling events	2.0	170.0	62.0	-0.075	0.039	1000.0	-1000.0	-0.046	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	2.0	140.0	52.0	-0.07	0.031	1000.0	-1000.0	-0.033	-1000.0
TCGA08_p53	2.0	20.0	7.0	-0.013	0.012	1000.0	-1000.0	-0.005	-1000.0
FAS signaling pathway (CD95)	2.0	94.0	47.0	-0.058	0.013	1000.0	-1000.0	-0.018	-1000.0
IL2 signaling events mediated by PI3K	2.0	132.0	58.0	-0.085	0.013	1000.0	-1000.0	-0.054	-1000.0
Canonical Wnt signaling pathway	2.0	108.0	51.0	-0.08	0.038	1000.0	-1000.0	-0.029	-1000.0
Calcium signaling in the CD4+ TCR pathway	2.0	63.0	31.0	-0.053	0.009	1000.0	-1000.0	-0.041	-1000.0
Insulin Pathway	2.0	152.0	74.0	-0.186	0.024	1000.0	-1000.0	-0.041	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	2.0	317.0	120.0	-0.117	0.101	1000.0	-1000.0	-0.038	-1000.0
Regulation of Androgen receptor activity	2.0	142.0	70.0	-0.141	0.019	1000.0	-1000.0	-0.041	-1000.0
LPA4-mediated signaling events	1.0	21.0	12.0	-0.021	0.012	1000.0	-1000.0	-0.013	-1000.0
Regulation of nuclear SMAD2/3 signaling	1.0	167.0	136.0	-0.095	0.094	1000.0	-1000.0	-0.022	-1000.0
ErbB4 signaling events	1.0	127.0	69.0	-0.131	0.028	1000.0	-1000.0	-0.048	-1000.0
BARD1 signaling events	1.0	107.0	57.0	-0.019	0.025	1000.0	-1000.0	-0.026	-1000.0
Circadian rhythm pathway	1.0	35.0	22.0	-0.037	0.012	1000.0	-1000.0	-0.034	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	1.0	155.0	85.0	-0.027	0.015	1000.0	-1000.0	-0.038	-1000.0
Presenilin action in Notch and Wnt signaling	1.0	121.0	61.0	-0.08	0.028	1000.0	-1000.0	-0.04	-1000.0
Aurora A signaling	1.0	82.0	60.0	-0.084	0.03	1000.0	-1000.0	-0.009	-1000.0
mTOR signaling pathway	1.0	62.0	53.0	-0.017	0.014	1000.0	-1000.0	-0.032	-1000.0
IFN-gamma pathway	1.0	81.0	68.0	-0.054	0.038	1000.0	-1000.0	-0.052	-1000.0
Ceramide signaling pathway	1.0	120.0	76.0	-0.076	0.03	1000.0	-1000.0	-0.016	-1000.0
Signaling events mediated by HDAC Class III	1.0	76.0	40.0	-0.12	0.02	1000.0	-1000.0	-0.016	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	107.0	83.0	-0.079	0.034	1000.0	-1000.0	-0.032	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	70.0	36.0	-0.077	0.021	1000.0	-1000.0	-0.033	-1000.0
Atypical NF-kappaB pathway	1.0	41.0	31.0	-0.014	0.019	1000.0	-1000.0	-0.012	-1000.0
Regulation of p38-alpha and p38-beta	1.0	66.0	54.0	-0.059	0.023	1000.0	-1000.0	-0.037	-1000.0
Effects of Botulinum toxin	1.0	30.0	26.0	-0.063	0.016	1000.0	-1000.0	-0.03	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	143.0	125.0	-0.05	0.04	1000.0	-1000.0	-0.044	-1000.0
IL27-mediated signaling events	1.0	68.0	51.0	-0.101	0.018	1000.0	-1000.0	-0.042	-1000.0
TCGA08_rtk_signaling	1.0	44.0	26.0	-0.046	0.026	1000.0	-1000.0	-0.01	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	1.0	104.0	74.0	-0.076	0.036	1000.0	-1000.0	-0.047	-1000.0
E-cadherin signaling in the nascent adherens junction	1.0	82.0	76.0	-0.039	0.027	1000.0	-1000.0	-0.046	-1000.0
Class I PI3K signaling events	1.0	92.0	73.0	-0.059	0.02	1000.0	-1000.0	-0.025	-1000.0
Regulation of Telomerase	1.0	182.0	102.0	-0.17	0.026	1000.0	-1000.0	-0.065	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	40.0	33.0	-0.069	0.027	1000.0	-1000.0	-0.024	-1000.0
PDGFR-beta signaling pathway	1.0	107.0	97.0	-0.111	0.036	1000.0	-1000.0	-0.039	-1000.0
E-cadherin signaling in keratinocytes	1.0	55.0	43.0	-0.016	0.023	1000.0	-1000.0	-0.025	-1000.0
p38 MAPK signaling pathway	1.0	51.0	44.0	-0.054	0.017	1000.0	-1000.0	-0.037	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	4.0	23.0	-0.004	0.03	1000.0	-1000.0	-0.027	-1000.0
Canonical NF-kappaB pathway	0.0	16.0	39.0	-0.045	0.032	1000.0	-1000.0	-0.043	-1000.0
Signaling events mediated by HDAC Class II	0.0	22.0	75.0	-0.034	0.023	1000.0	-1000.0	-0.022	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	0.002	0.01	1000.0	-1000.0	-0.009	-1000.0
Arf6 downstream pathway	0.0	7.0	43.0	-0.019	0.019	1000.0	-1000.0	-0.024	-1000.0
Insulin-mediated glucose transport	0.0	29.0	32.0	-0.035	0.023	1000.0	-1000.0	-0.025	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	31.0	68.0	-0.022	0.029	1000.0	-1000.0	-0.021	-1000.0
ceramide signaling pathway	0.0	24.0	49.0	-0.006	0.03	1000.0	-1000.0	-0.016	-1000.0
Signaling events mediated by HDAC Class I	0.0	15.0	104.0	-0.034	0.033	1000.0	-1000.0	-0.022	-1000.0
FoxO family signaling	0.0	53.0	64.0	-0.058	0.054	1000.0	-1000.0	-0.049	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	0.0	37.0	45.0	-0.021	0.039	1000.0	-1000.0	-0.045	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	-0.0	0.023	1000.0	-1000.0	-0.027	-1000.0
Arf6 trafficking events	0.0	40.0	71.0	-0.042	0.028	1000.0	-1000.0	-0.037	-1000.0
VEGFR1 specific signals	0.0	20.0	56.0	-0.017	0.034	1000.0	-1000.0	-0.028	-1000.0
Rapid glucocorticoid signaling	0.0	18.0	20.0	-0.023	0.013	1000.0	-1000.0	-0.009	-1000.0
Signaling events mediated by PRL	0.0	21.0	34.0	-0.02	0.013	1000.0	-1000.0	-0.023	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	-0.004	0.021	1000.0	-1000.0	-0.009	-1000.0
Arf1 pathway	0.0	9.0	54.0	-0.019	0.017	1000.0	-1000.0	-0.015	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.027	1000.0	-1000.0	-0.01	-1000.0
Total	421	25815	7203	-11.8307746932	-996.950843525	131000	-131000	-4.38258224135	-131000