Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.043 0.251 0.366 5.0 -0.558 12.0 17.0 IHH 0.004 0.141 0.244 6.0 -0.228 14.0 20.0 SHH Np/Cholesterol/GAS1 -0.05 0.127 -9999.0 0.0 -0.267 18.0 18.0 LRPAP1 0.021 0.008 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.05 0.126 0.265 18.0 -9999.0 0.0 18.0 SMO/beta Arrestin2 -0.078 0.182 -9999.0 0.0 -0.353 15.0 15.0 SMO -0.085 0.181 0.257 1.0 -0.364 15.0 16.0 AKT1 -0.041 0.132 -9999.0 0.0 -0.636 2.0 2.0 ARRB2 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.017 0.081 0.24 2.0 -0.428 2.0 4.0 ADRBK1 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.084 0.179 0.256 1.0 -0.36 15.0 16.0 STIL -0.068 0.147 0.276 3.0 -0.286 12.0 15.0 DHH N/PTCH2 0.041 0.078 0.185 10.0 -0.309 2.0 12.0 DHH N/PTCH1 -0.011 0.141 0.318 1.0 -0.275 13.0 14.0 PIK3CA 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.035 0.104 0.24 9.0 -0.428 2.0 11.0 PTHLH -0.099 0.354 0.699 1.0 -0.86 12.0 13.0 determination of left/right symmetry -0.084 0.179 0.256 1.0 -0.36 15.0 16.0 PIK3R1 0.006 0.091 0.24 1.0 -0.428 3.0 4.0 skeletal system development -0.098 0.35 0.698 1.0 -0.849 12.0 13.0 IHH N/Hhip -0.026 0.168 0.21 6.0 -0.324 16.0 22.0 DHH N/Hhip -0.003 0.147 0.199 11.0 -0.285 14.0 25.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.084 0.179 0.256 1.0 -0.36 15.0 16.0 pancreas development -0.032 0.182 0.24 7.0 -0.427 12.0 19.0 HHAT 0.012 0.072 -9999.0 0.0 -0.428 2.0 2.0 PI3K 0.018 0.069 0.185 1.0 -0.309 3.0 4.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.004 0.115 0.24 1.0 -0.428 5.0 6.0 somite specification -0.084 0.179 0.256 1.0 -0.36 15.0 16.0 SHH Np/Cholesterol/PTCH1 -0.062 0.15 0.312 2.0 -0.251 24.0 26.0 SHH Np/Cholesterol/PTCH2 -0.03 0.118 0.228 2.0 -0.249 15.0 17.0 SHH Np/Cholesterol/Megalin -0.046 0.105 -9999.0 0.0 -0.245 15.0 15.0 SHH -0.067 0.134 0.164 4.0 -0.32 15.0 19.0 catabolic process -0.024 0.151 0.259 2.0 -0.323 13.0 15.0 SMO/Vitamin D3 -0.087 0.168 0.334 2.0 -0.324 14.0 16.0 SHH Np/Cholesterol/Hhip -0.063 0.159 0.188 5.0 -0.278 23.0 28.0 LRP2 0.007 0.034 0.24 1.0 -9999.0 0.0 1.0 receptor-mediated endocytosis -0.088 0.163 0.293 2.0 -0.328 13.0 15.0 SHH Np/Cholesterol/BOC -0.038 0.116 0.151 1.0 -0.243 17.0 18.0 SHH Np/Cholesterol/CDO -0.043 0.114 0.153 1.0 -0.24 18.0 19.0 mesenchymal cell differentiation 0.062 0.157 0.276 23.0 -0.186 5.0 28.0 mol:Vitamin D3 -0.057 0.161 0.327 3.0 -0.288 12.0 15.0 IHH N/PTCH2 0.025 0.094 0.208 3.0 -0.276 4.0 7.0 CDON 0.013 0.098 0.24 3.0 -0.428 3.0 6.0 IHH N/PTCH1 -0.008 0.167 0.329 3.0 -0.325 13.0 16.0 Megalin/LRPAP1 0.032 0.021 0.185 1.0 -9999.0 0.0 1.0 PTCH2 0.028 0.035 0.24 2.0 -9999.0 0.0 2.0 SHH Np/Cholesterol -0.054 0.098 -9999.0 0.0 -0.243 15.0 15.0 PTCH1 -0.024 0.152 0.259 2.0 -0.324 13.0 15.0 HHIP -0.032 0.182 0.24 7.0 -0.428 12.0 19.0