E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.03 0.095 -9999.0 0.0 -0.452 13.0 13.0 KLHL20 -0.013 0.04 -9999.0 0.0 -0.207 3.0 3.0 CYFIP2 -0.001 0.098 -9999.0 0.0 -0.576 10.0 10.0 Rac1/GDP 0.058 0.061 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.031 0.094 -9999.0 0.0 -0.452 13.0 13.0 AP1M1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.006 0.033 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.011 0.03 -9999.0 0.0 -0.196 1.0 1.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.024 0.077 -9999.0 0.0 -0.323 16.0 16.0 RAPGEF1 0.046 0.083 -9999.0 0.0 -0.38 13.0 13.0 CTNND1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.02 0.096 -9999.0 0.0 -0.473 13.0 13.0 CRK 0.039 0.089 -9999.0 0.0 -0.418 13.0 13.0 E-cadherin/gamma catenin/alpha catenin 0.015 0.079 -9999.0 0.0 -0.367 14.0 14.0 alphaE/beta7 Integrin 0.018 0.046 -9999.0 0.0 -0.414 4.0 4.0 IQGAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.03 0.001 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 0.031 0.094 -9999.0 0.0 -0.452 13.0 13.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.005 0.024 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.027 0.03 -9999.0 0.0 -0.296 3.0 3.0 PI3K -0.006 0.03 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.005 0.091 -9999.0 0.0 -0.439 14.0 14.0 TIAM1 0.012 0.044 -9999.0 0.0 -0.576 2.0 2.0 E-cadherin(dimer)/Ca2+ 0.024 0.061 -9999.0 0.0 -0.286 13.0 13.0 AKT1 -0.003 0.017 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.006 0.111 -9999.0 0.0 -0.576 13.0 13.0 RhoA/GDP 0.057 0.061 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.04 0.046 -9999.0 0.0 -0.152 3.0 3.0 CDC42/GDP 0.057 0.061 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.017 0.061 -9999.0 0.0 -0.275 14.0 14.0 ITGB7 0.009 0.062 -9999.0 0.0 -0.576 4.0 4.0 RAC1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.026 0.065 -9999.0 0.0 -0.304 13.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.015 0.06 -9999.0 0.0 -0.294 13.0 13.0 mol:GDP 0.053 0.069 -9999.0 0.0 -0.299 12.0 12.0 CDC42/GTP/IQGAP1 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.012 0.044 -9999.0 0.0 -0.576 2.0 2.0 p120 catenin/RhoA/GDP -0.01 0.048 -9999.0 0.0 -9999.0 0.0 0.0 RAC1/GTP/IQGAP1 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.023 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.026 0.056 -9999.0 0.0 -0.195 18.0 18.0 NME1 0.014 0.028 -9999.0 0.0 -0.507 1.0 1.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.031 0.094 -9999.0 0.0 -0.452 13.0 13.0 regulation of cell-cell adhesion -0.006 0.03 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.006 0.015 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.007 0.039 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.029 0.079 -9999.0 0.0 -0.58 2.0 2.0 CCND1 0.03 0.068 -9999.0 0.0 -0.242 18.0 18.0 VAV2 0.039 0.103 -9999.0 0.0 -0.442 15.0 15.0 RAP1/GDP 0.054 0.054 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.031 0.091 -9999.0 0.0 -0.438 13.0 13.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.037 0.077 -9999.0 0.0 -0.552 2.0 2.0 E-cadherin/beta catenin -0.014 0.071 -9999.0 0.0 -0.379 13.0 13.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.029 0.094 -9999.0 0.0 -0.452 13.0 13.0 PIK3CA 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.02 0.064 -9999.0 0.0 -0.336 3.0 3.0 E-cadherin/beta catenin/alpha catenin 0.017 0.07 -9999.0 0.0 -0.343 13.0 13.0 ITGAE 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.018 0.091 -9999.0 0.0 -0.483 13.0 13.0