Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXM1 transcription factor network	130.0	6663.0	51.0	-0.857	0.016	1000.0	-1000.0	-0.132	-1000.0
Glypican 2 network	103.0	412.0	4.0	-0.166	-0.127	1000.0	-1000.0	-0.011	-1000.0
Aurora B signaling	94.0	6364.0	67.0	-0.513	0.016	1000.0	-1000.0	-0.057	-1000.0
Signaling events regulated by Ret tyrosine kinase	72.0	5937.0	82.0	-0.315	0.016	1000.0	-1000.0	-0.073	-1000.0
Signaling mediated by p38-alpha and p38-beta	72.0	3176.0	44.0	-0.258	0.016	1000.0	-1000.0	-0.049	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	72.0	4945.0	68.0	-0.724	0.358	1000.0	-1000.0	-0.096	-1000.0
Nongenotropic Androgen signaling	61.0	3196.0	52.0	-0.251	0.141	1000.0	-1000.0	-0.055	-1000.0
Signaling events mediated by the Hedgehog family	60.0	3150.0	52.0	-0.183	0.181	1000.0	-1000.0	-0.047	-1000.0
IL4-mediated signaling events	59.0	5374.0	91.0	-0.78	0.557	1000.0	-1000.0	-0.103	-1000.0
Endothelins	56.0	5377.0	96.0	-0.327	0.042	1000.0	-1000.0	-0.059	-1000.0
IGF1 pathway	55.0	3158.0	57.0	-0.254	0.047	1000.0	-1000.0	-0.079	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	52.0	4092.0	78.0	-0.265	0.093	1000.0	-1000.0	-0.048	-1000.0
Reelin signaling pathway	50.0	2801.0	56.0	-0.237	0.04	1000.0	-1000.0	-0.078	-1000.0
TCGA08_p53	50.0	354.0	7.0	-0.173	0.078	1000.0	-1000.0	-0.011	-1000.0
Thromboxane A2 receptor signaling	49.0	5169.0	105.0	-0.205	0.037	1000.0	-1000.0	-0.057	-1000.0
Aurora C signaling	48.0	342.0	7.0	-0.22	0.0	1000.0	-1000.0	-0.024	-1000.0
TCGA08_retinoblastoma	48.0	390.0	8.0	-0.248	0.068	1000.0	-1000.0	-0.012	-1000.0
Fc-epsilon receptor I signaling in mast cells	46.0	4556.0	97.0	-0.197	0.042	1000.0	-1000.0	-0.072	-1000.0
p75(NTR)-mediated signaling	45.0	5663.0	125.0	-0.174	0.046	1000.0	-1000.0	-0.085	-1000.0
PLK1 signaling events	43.0	3735.0	85.0	-0.374	0.051	1000.0	-1000.0	-0.037	-1000.0
IL23-mediated signaling events	43.0	2620.0	60.0	-0.615	0.016	1000.0	-1000.0	-0.111	-1000.0
Ephrin A  reverse signaling	42.0	295.0	7.0	-0.072	0.0	1000.0	-1000.0	-0.018	-1000.0
HIF-1-alpha transcription factor network	42.0	3226.0	76.0	-0.361	0.033	1000.0	-1000.0	-0.064	-1000.0
Plasma membrane estrogen receptor signaling	42.0	3636.0	86.0	-0.252	0.122	1000.0	-1000.0	-0.067	-1000.0
Ras signaling in the CD4+ TCR pathway	42.0	721.0	17.0	-0.159	0.022	1000.0	-1000.0	-0.023	-1000.0
Integrins in angiogenesis	41.0	3493.0	84.0	-0.276	0.032	1000.0	-1000.0	-0.076	-1000.0
Rapid glucocorticoid signaling	41.0	837.0	20.0	-0.24	0.037	1000.0	-1000.0	-0.01	-1000.0
BMP receptor signaling	40.0	3244.0	81.0	-0.331	0.053	1000.0	-1000.0	-0.082	-1000.0
Glypican 1 network	38.0	1849.0	48.0	-0.264	0.036	1000.0	-1000.0	-0.025	-1000.0
amb2 Integrin signaling	38.0	3149.0	82.0	-0.336	0.021	1000.0	-1000.0	-0.068	-1000.0
Calcium signaling in the CD4+ TCR pathway	38.0	1181.0	31.0	-0.299	0.016	1000.0	-1000.0	-0.072	-1000.0
IL6-mediated signaling events	38.0	2862.0	75.0	-0.25	0.07	1000.0	-1000.0	-0.063	-1000.0
Syndecan-1-mediated signaling events	37.0	1287.0	34.0	-0.283	0.016	1000.0	-1000.0	-0.033	-1000.0
TCR signaling in naïve CD8+ T cells	37.0	3519.0	93.0	-0.147	0.063	1000.0	-1000.0	-0.067	-1000.0
LPA receptor mediated events	36.0	3674.0	102.0	-0.234	0.032	1000.0	-1000.0	-0.065	-1000.0
Glucocorticoid receptor regulatory network	35.0	4038.0	114.0	-0.605	0.27	1000.0	-1000.0	-0.069	-1000.0
PDGFR-alpha signaling pathway	34.0	1516.0	44.0	-0.336	0.033	1000.0	-1000.0	-0.053	-1000.0
S1P1 pathway	34.0	1253.0	36.0	-0.315	0.016	1000.0	-1000.0	-0.047	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	33.0	3997.0	120.0	-0.328	0.183	1000.0	-1000.0	-0.07	-1000.0
S1P5 pathway	31.0	541.0	17.0	-0.167	0.112	1000.0	-1000.0	-0.027	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	31.0	1655.0	52.0	-0.316	0.028	1000.0	-1000.0	-0.048	-1000.0
IL12-mediated signaling events	29.0	2574.0	87.0	-0.418	0.035	1000.0	-1000.0	-0.093	-1000.0
Visual signal transduction: Cones	29.0	1130.0	38.0	-0.13	0.017	1000.0	-1000.0	-0.056	-1000.0
LPA4-mediated signaling events	28.0	345.0	12.0	-0.171	0.023	1000.0	-1000.0	-0.015	-1000.0
Osteopontin-mediated events	28.0	1095.0	38.0	-0.186	0.017	1000.0	-1000.0	-0.084	-1000.0
BCR signaling pathway	28.0	2814.0	99.0	-0.191	0.037	1000.0	-1000.0	-0.076	-1000.0
S1P4 pathway	28.0	703.0	25.0	-0.167	0.031	1000.0	-1000.0	-0.034	-1000.0
JNK signaling in the CD4+ TCR pathway	27.0	459.0	17.0	-0.155	0.019	1000.0	-1000.0	-0.026	-1000.0
Coregulation of Androgen receptor activity	26.0	2013.0	76.0	-0.236	0.033	1000.0	-1000.0	-0.042	-1000.0
Syndecan-2-mediated signaling events	26.0	1835.0	69.0	-0.087	0.031	1000.0	-1000.0	-0.026	-1000.0
S1P3 pathway	26.0	1112.0	42.0	-0.166	0.032	1000.0	-1000.0	-0.027	-1000.0
Aurora A signaling	25.0	1554.0	60.0	-0.364	0.031	1000.0	-1000.0	-0.043	-1000.0
Angiopoietin receptor Tie2-mediated signaling	25.0	2287.0	88.0	-0.233	0.048	1000.0	-1000.0	-0.091	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	24.0	1338.0	54.0	-0.203	0.031	1000.0	-1000.0	-0.086	-1000.0
Arf6 signaling events	24.0	1510.0	62.0	-0.236	0.03	1000.0	-1000.0	-0.042	-1000.0
Class IB PI3K non-lipid kinase events	24.0	72.0	3.0	-0.024	-1000.0	1000.0	-1000.0	-0.008	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	22.0	755.0	34.0	-0.052	0.016	1000.0	-1000.0	-0.051	-1000.0
Syndecan-4-mediated signaling events	22.0	1498.0	67.0	-0.19	0.02	1000.0	-1000.0	-0.067	-1000.0
FAS signaling pathway (CD95)	21.0	1010.0	47.0	-0.569	0.019	1000.0	-1000.0	-0.026	-1000.0
Wnt signaling	21.0	153.0	7.0	-0.058	0.016	1000.0	-1000.0	-0.022	-1000.0
Presenilin action in Notch and Wnt signaling	20.0	1262.0	61.0	-0.181	0.044	1000.0	-1000.0	-0.053	-1000.0
Visual signal transduction: Rods	20.0	1047.0	52.0	-0.21	0.016	1000.0	-1000.0	-0.073	-1000.0
Canonical Wnt signaling pathway	19.0	1007.0	51.0	-0.181	0.083	1000.0	-1000.0	-0.039	-1000.0
Noncanonical Wnt signaling pathway	18.0	487.0	26.0	-0.1	0.016	1000.0	-1000.0	-0.044	-1000.0
Sphingosine 1-phosphate (S1P) pathway	17.0	500.0	28.0	-0.167	0.03	1000.0	-1000.0	-0.022	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	17.0	564.0	33.0	-0.288	0.046	1000.0	-1000.0	-0.047	-1000.0
ErbB2/ErbB3 signaling events	16.0	1075.0	65.0	-0.238	0.027	1000.0	-1000.0	-0.06	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	16.0	1397.0	85.0	-0.218	0.023	1000.0	-1000.0	-0.063	-1000.0
Effects of Botulinum toxin	16.0	416.0	26.0	-0.072	0.016	1000.0	-1000.0	-0.056	-1000.0
Caspase cascade in apoptosis	15.0	1155.0	74.0	-0.058	0.043	1000.0	-1000.0	-0.029	-1000.0
ErbB4 signaling events	15.0	1089.0	69.0	-0.238	0.038	1000.0	-1000.0	-0.07	-1000.0
FOXA2 and FOXA3 transcription factor networks	15.0	725.0	46.0	-0.192	0.095	1000.0	-1000.0	-0.037	-1000.0
Regulation of Androgen receptor activity	14.0	988.0	70.0	-0.22	0.03	1000.0	-1000.0	-0.048	-1000.0
Hedgehog signaling events mediated by Gli proteins	13.0	863.0	65.0	-0.167	0.067	1000.0	-1000.0	-0.047	-1000.0
Nectin adhesion pathway	13.0	881.0	63.0	-0.054	0.03	1000.0	-1000.0	-0.061	-1000.0
IL27-mediated signaling events	13.0	713.0	51.0	-0.25	0.029	1000.0	-1000.0	-0.066	-1000.0
EGFR-dependent Endothelin signaling events	13.0	293.0	21.0	-0.071	0.023	1000.0	-1000.0	-0.062	-1000.0
IL2 signaling events mediated by STAT5	12.0	284.0	22.0	-0.122	0.068	1000.0	-1000.0	-0.036	-1000.0
Regulation of nuclear SMAD2/3 signaling	11.0	1527.0	136.0	-0.198	0.069	1000.0	-1000.0	-0.063	-1000.0
Cellular roles of Anthrax toxin	11.0	464.0	39.0	-0.103	0.018	1000.0	-1000.0	-0.019	-1000.0
IL2 signaling events mediated by PI3K	11.0	653.0	58.0	-0.209	0.055	1000.0	-1000.0	-0.066	-1000.0
Signaling events mediated by PTP1B	10.0	815.0	76.0	-0.137	0.036	1000.0	-1000.0	-0.065	-1000.0
Syndecan-3-mediated signaling events	10.0	364.0	35.0	-0.132	0.046	1000.0	-1000.0	-0.035	-1000.0
Signaling events mediated by HDAC Class III	9.0	383.0	40.0	-0.226	0.026	1000.0	-1000.0	-0.031	-1000.0
IL1-mediated signaling events	9.0	615.0	62.0	-0.094	0.075	1000.0	-1000.0	-0.081	-1000.0
Ephrin B reverse signaling	9.0	468.0	48.0	-0.057	0.018	1000.0	-1000.0	-0.059	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	9.0	788.0	83.0	-0.276	0.043	1000.0	-1000.0	-0.056	-1000.0
Regulation of p38-alpha and p38-beta	9.0	510.0	54.0	-0.153	0.043	1000.0	-1000.0	-0.05	-1000.0
BARD1 signaling events	8.0	468.0	57.0	-0.164	0.045	1000.0	-1000.0	-0.048	-1000.0
a4b1 and a4b7 Integrin signaling	8.0	44.0	5.0	-0.004	0.009	1000.0	-1000.0	-0.015	-1000.0
Class I PI3K signaling events mediated by Akt	8.0	569.0	68.0	-0.212	0.061	1000.0	-1000.0	-0.044	-1000.0
EPHB forward signaling	8.0	697.0	85.0	-0.047	0.041	1000.0	-1000.0	-0.078	-1000.0
Regulation of Telomerase	8.0	886.0	102.0	-0.169	0.038	1000.0	-1000.0	-0.099	-1000.0
Signaling events mediated by PRL	8.0	273.0	34.0	-0.1	0.026	1000.0	-1000.0	-0.028	-1000.0
E-cadherin signaling events	8.0	42.0	5.0	-0.006	0.016	1000.0	-1000.0	-0.016	-1000.0
EPO signaling pathway	7.0	403.0	55.0	-0.047	0.057	1000.0	-1000.0	-0.073	-1000.0
IFN-gamma pathway	7.0	487.0	68.0	-0.182	0.056	1000.0	-1000.0	-0.079	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	7.0	280.0	37.0	-0.031	0.035	1000.0	-1000.0	-0.044	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	7.0	570.0	74.0	-0.248	0.077	1000.0	-1000.0	-0.077	-1000.0
Arf6 trafficking events	7.0	533.0	71.0	-0.415	0.05	1000.0	-1000.0	-0.061	-1000.0
Insulin Pathway	7.0	570.0	74.0	-0.258	0.042	1000.0	-1000.0	-0.082	-1000.0
PDGFR-beta signaling pathway	7.0	754.0	97.0	-0.056	0.054	1000.0	-1000.0	-0.075	-1000.0
TRAIL signaling pathway	6.0	316.0	48.0	-0.011	0.051	1000.0	-1000.0	-0.057	-1000.0
Ceramide signaling pathway	5.0	384.0	76.0	-0.248	0.044	1000.0	-1000.0	-0.028	-1000.0
Signaling mediated by p38-gamma and p38-delta	5.0	89.0	15.0	-0.0	0.032	1000.0	-1000.0	-0.021	-1000.0
Retinoic acid receptors-mediated signaling	5.0	315.0	58.0	-0.08	0.036	1000.0	-1000.0	-0.062	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	5.0	247.0	45.0	-0.032	0.068	1000.0	-1000.0	-0.077	-1000.0
TCGA08_rtk_signaling	5.0	134.0	26.0	-0.069	0.048	1000.0	-1000.0	-0.014	-1000.0
PLK2 and PLK4 events	4.0	14.0	3.0	0.005	0.019	1000.0	-1000.0	-0.009	-1000.0
E-cadherin signaling in the nascent adherens junction	4.0	369.0	76.0	-0.02	0.058	1000.0	-1000.0	-0.07	-1000.0
Signaling events mediated by HDAC Class II	3.0	269.0	75.0	-0.086	0.039	1000.0	-1000.0	-0.037	-1000.0
HIF-2-alpha transcription factor network	3.0	147.0	43.0	-0.155	0.158	1000.0	-1000.0	-0.061	-1000.0
Paxillin-dependent events mediated by a4b1	3.0	123.0	36.0	-0.035	0.036	1000.0	-1000.0	-0.056	-1000.0
Class I PI3K signaling events	3.0	253.0	73.0	-0.054	0.041	1000.0	-1000.0	-0.057	-1000.0
E-cadherin signaling in keratinocytes	3.0	129.0	43.0	-0.046	0.048	1000.0	-1000.0	-0.056	-1000.0
p38 MAPK signaling pathway	3.0	160.0	44.0	-0.044	0.047	1000.0	-1000.0	-0.054	-1000.0
Canonical NF-kappaB pathway	2.0	91.0	39.0	-0.021	0.092	1000.0	-1000.0	-0.069	-1000.0
ceramide signaling pathway	2.0	99.0	49.0	-0.024	0.051	1000.0	-1000.0	-0.033	-1000.0
FoxO family signaling	2.0	160.0	64.0	-0.067	0.098	1000.0	-1000.0	-0.048	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	310.0	125.0	-0.054	0.099	1000.0	-1000.0	-0.082	-1000.0
Circadian rhythm pathway	1.0	36.0	22.0	-0.016	0.053	1000.0	-1000.0	-0.039	-1000.0
Insulin-mediated glucose transport	1.0	60.0	32.0	-0.142	0.042	1000.0	-1000.0	-0.046	-1000.0
mTOR signaling pathway	1.0	63.0	53.0	-0.006	0.042	1000.0	-1000.0	-0.056	-1000.0
VEGFR1 specific signals	1.0	89.0	56.0	-0.051	0.071	1000.0	-1000.0	-0.041	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	12.0	23.0	0.007	0.055	1000.0	-1000.0	-0.045	-1000.0
Arf6 downstream pathway	0.0	20.0	43.0	-0.039	0.039	1000.0	-1000.0	-0.03	-1000.0
Signaling events mediated by HDAC Class I	0.0	81.0	104.0	-0.031	0.066	1000.0	-1000.0	-0.059	-1000.0
Atypical NF-kappaB pathway	0.0	23.0	31.0	-0.0	0.056	1000.0	-1000.0	-0.026	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	24.0	27.0	-0.002	0.039	1000.0	-1000.0	-0.045	-1000.0
Arf1 pathway	0.0	6.0	54.0	-0.0	0.04	1000.0	-1000.0	-0.028	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.046	1000.0	-1000.0	-0.026	-1000.0
Total	3095	179636	7203	-24.6106680552	-993.215730207	131000	-131000	-6.84726276483	-131000