Clinical Features CN_CNMF METHLYATION_CNMF RPPA_CNMF RPPA_CHIERARCHICAL MRNASEQ_CNMF MRNASEQ_CHIERARCHICAL MIRSEQ_CNMF MIRSEQ_CHIERARCHICAL MIRSEQ_MATURE_CNMF MIRSEQ_MATURE_CHIERARCHICAL nMutated (%) nWild-Type Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q TP53 64 (49%) 66 0.00089999 0.312 0.3496 1 0.03948 1 0.0070099 1 0.29446 1 0.18018 1 0.33478 1 0.3375 1 0.64243 1 0.13083 1 KDM6A 31 (24%) 99 0.089079 1 0.9646 1 0.34141 1 0.13359 1 0.3961 1 0.86479 1 0.26586 1 0.2236 1 0.96282 1 0.86601 1 RB1 17 (13%) 113 9.9999e-06 0.0035 0.39028 1 0.59039 1 0.31537 1 0.57266 1 0.51651 1 0.48028 1 0.68072 1 0.16436 1 0.27963 1 ARID1A 32 (25%) 98 0.41803 1 0.60299 1 0.58782 1 0.079829 1 0.40476 1 0.21656 1 0.25601 1 0.01788 1 0.071169 1 0.389 1 CDKN1A 18 (14%) 112 0.31517 1 1 1 0.82932 1 0.82313 1 0.65358 1 0.65243 1 0.72539 1 0.75695 1 0.77403 1 0.5293 1 MLL2 36 (28%) 94 0.71029 1 0.53016 1 0.36775 1 0.32799 1 0.17936 1 0.25945 1 0.32333 1 0.4395 1 0.38694 1 0.61204 1 ELF3 11 (8%) 119 0.48869 1 0.32755 1 0.75503 1 0.38623 1 0.66909 1 0.23694 1 0.40764 1 0.56594 1 0.64364 1 0.79481 1 FGFR3 16 (12%) 114 0.11849 1 0.27735 1 0.091119 1 0.0095499 1 0.20955 1 0.0096999 1 0.12024 1 0.053809 1 0.00143 0.493 9.9999e-06 0.0035 CDKN2A 7 (5%) 123 0.27174 1 1 1 0.39053 1 0.18383 1 1 1 1 1 0.41114 1 0.21446 1 0.85896 1 0.41109 1 STAG2 14 (11%) 116 0.67983 1 0.30685 1 0.3033 1 0.55463 1 0.34579 1 0.098789 1 0.27588 1 0.4171 1 0.41196 1 0.22392 1 NFE2L2 11 (8%) 119 0.02485 1 0.16397 1 0.30502 1 0.72537 1 0.067009 1 0.10215 1 0.85736 1 0.24004 1 1 1 0.35843 1 ERCC2 16 (12%) 114 0.79867 1 0.73494 1 0.086549 1 0.01787 1 0.16197 1 0.082369 1 0.27213 1 0.34916 1 0.04154 1 0.00319 1 FBXW7 13 (10%) 117 0.71728 1 0.0056999 1 0.26228 1 0.53281 1 0.074849 1 0.03832 1 0.29257 1 0.0119 1 0.00039 0.136 0.00096999 0.336 RHOB 7 (5%) 123 0.02398 1 1 1 0.55803 1 0.31979 1 0.79446 1 0.5017 1 0.88379 1 0.23968 1 0.81848 1 0.72342 1 TSC1 11 (8%) 119 0.39057 1 0.50799 1 0.41357 1 0.56768 1 0.26541 1 0.50844 1 0.85559 1 0.80061 1 0.57064 1 0.8446 1 FOXQ1 7 (5%) 123 0.11592 1 0.47381 1 0.46952 1 0.36706 1 0.88384 1 1 1 0.20217 1 0.36683 1 0.85806 1 0.86948 1 PIK3CA 26 (20%) 104 0.19178 1 0.41736 1 0.22806 1 0.64273 1 0.64518 1 0.27685 1 0.78587 1 0.45967 1 0.26899 1 0.65166 1 RXRA 12 (9%) 118 0.12383 1 0.10171 1 0.17068 1 0.92263 1 0.5955 1 0.78778 1 0.50902 1 0.23337 1 0.94708 1 0.88193 1 CREBBP 17 (13%) 113 0.02652 1 0.70907 1 0.92134 1 0.54577 1 0.20045 1 0.46686 1 0.60262 1 0.53188 1 0.29993 1 0.79983 1 ERBB3 14 (11%) 116 0.58634 1 0.61692 1 0.69013 1 0.49279 1 0.76869 1 0.8869 1 0.62628 1 0.65379 1 0.84735 1 0.38931 1 FAT1 15 (12%) 115 0.01056 1 0.59975 1 0.2217 1 0.43604 1 0.32096 1 0.95844 1 0.60637 1 0.84328 1 0.31913 1 0.10756 1 MLL 18 (14%) 112 0.32621 1 1 1 0.02979 1 0.0048 1 0.28943 1 0.46468 1 0.9468 1 0.41743 1 0.17697 1 0.44234 1 HRAS 6 (5%) 124 0.89065 1 0.3078 1 0.01777 1 0.33803 1 0.88123 1 0.64257 1 0.6572 1 0.64346 1 0.66166 1 0.77123 1 ACRC 4 (3%) 126 0.74425 1 0.02764 1 0.8549 1 0.76244 1 0.46838 1 0.82372 1 1 1 0.55572 1 0.90115 1 0.85478 1 TXNIP 9 (7%) 121 0.91894 1 0.54981 1 0.87436 1 0.70618 1 1 1 0.23772 1 1 1 0.98481 1 0.61862 1 0.87445 1 ECM1 5 (4%) 125 0.35016 1 0.72266 1 0.94515 1 0.18122 1 0.72864 1 0.47632 1 0.17483 1 0.080559 1 0.79824 1 0.71277 1 KLF5 10 (8%) 120 1 1 0.70017 1 0.3009 1 0.31087 1 0.91536 1 0.43548 1 0.84284 1 0.14576 1 0.31305 1 0.25883 1 RBM26 9 (7%) 121 0.00335 1 0.74093 1 0.25661 1 0.72579 1 0.34366 1 0.74881 1 0.14347 1 0.14297 1 0.80906 1 0.16884 1 RAD51C 4 (3%) 126 0.38528 1 0.42321 1 0.1804 1 1 1 0.03616 1 0.68567 1 0.81054 1 0.60465 1 0.36401 1 0.6077 1 CEP192 5 (4%) 125 0.86313 1 0.72482 1 0.89492 1 0.69307 1 0.7306 1 0.53728 1 0.22294 1 0.01851 1 0.79987 1 0.32147 1 ASXL2 9 (7%) 121 0.333 1 0.90515 1 0.34846 1 0.36448 1 0.24212 1 0.13629 1 0.74679 1 0.64263 1 0.13404 1 0.12736 1 PSIP1 7 (5%) 123 0.82126 1 0.14839 1 0.13696 1 0.38926 1 0.88446 1 0.27858 1 0.79364 1 0.56096 1 0.47913 1 0.1191 1 ZNF513 7 (5%) 123 0.4076 1 1 1 0.2076 1 0.41279 1 0.48076 1 0.31148 1 0.62745 1 0.31557 1 0.81675 1 0.51624 1 FOXA1 7 (5%) 123 0.04366 1 1 1 0.53481 1 0.69733 1 0.25939 1 0.95004 1 1 1 0.9361 1 0.27727 1 0.57439 1 TRIP11 5 (4%) 125 1 1 0.84336 1 0.80199 1 0.28753 1 0.73102 1 0.92932 1 0.13409 1 0.30752 1 1 1 0.66208 1