rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(18), DAXX(1), HRAS(6), PAX3(4), PML(3), RARA(3), RB1(19), SIRT1(1), SP100(6), TNFRSF1B(3), TP53(75) 3649856 139 81 109 8 41 1 51 7 39 0 2.12e-08 <1.00e-15 <3.08e-13 2 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF3(1), CCND1(1), CDK2(1), CDK4(2), CDKN1A(18), CDKN1B(5), CDKN2A(8), E2F1(1), E2F2(1), PRB1(1), TP53(75) 1619397 114 76 88 5 28 0 39 5 42 0 2.50e-07 <1.00e-15 <3.08e-13 3 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(1), MYC(1), SP1(3), SP3(2), TP53(75), WT1(2) 1363520 84 68 59 4 23 1 34 5 21 0 8.73e-06 3.77e-15 7.75e-13 4 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 DNAJA3(1), HSPA1A(2), IFNG(1), IFNGR2(2), IKBKB(4), JAK2(2), NFKB1(1), NFKBIA(2), RB1(19), RELA(2), TNFRSF1B(3), TP53(75), USH1C(1), WT1(2) 3492287 117 73 90 6 33 2 40 5 37 0 1.31e-07 5.11e-15 7.86e-13 5 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(6), DNAJC3(2), MAP3K14(2), NFKB1(1), NFKBIA(2), RELA(2), TP53(75) 1894134 90 67 65 4 27 0 36 4 23 0 5.00e-06 8.44e-15 1.04e-12 6 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CDK2(1), CUL1(8), E2F1(1), FBXW7(16), RB1(19) 1585537 45 36 38 1 14 1 6 2 22 0 0.000405 1.35e-13 1.38e-11 7 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(1), ATM(19), BAX(1), CCND1(1), CDK2(1), CDK4(2), CDKN1A(18), E2F1(1), GADD45A(1), PCNA(1), RB1(19), TP53(75) 3493410 140 87 112 12 36 2 41 8 53 0 0.000286 1.65e-12 1.45e-10 8 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(1), CCNB1(1), CCND1(1), CCND3(5), CCNH(3), CDC25A(1), CDK2(1), CDK4(2), CDK6(1), CDK7(3), CDKN1A(18), CDKN1B(5), CDKN2A(8), CDKN2B(2), CDKN2D(1), E2F1(1), RB1(19), RBL1(1) 3072916 74 51 71 5 19 2 10 3 40 0 0.00213 5.47e-12 4.21e-10 9 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(4), CDKN2A(8), E2F1(1), MYC(1), PIK3CA(26), PIK3R1(2), POLR1A(5), POLR1B(1), POLR1C(1), POLR1D(2), RAC1(1), RB1(19), TBX2(3), TP53(75) 3902579 149 79 107 12 57 4 40 9 39 0 8.02e-07 8.37e-12 5.73e-10 10 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 CCND1(1), CDK2(1), CDK4(2), CDK6(1), CDKN1A(18), CDKN1B(5), E2F1(1), HRAS(6), MAPK3(3), NFKB1(1), NFKBIA(2), PIK3CA(26), PIK3R1(2), RAC1(1), RAF1(1), RB1(19), RELA(2) 3908128 92 64 73 8 40 3 9 5 35 0 0.00102 1.05e-09 6.45e-08 11 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(6), ATM(19), BAX(1), CDKN1A(18), CPB2(3), CSNK1A1(3), GADD45A(1), HIF1A(1), HSPA1A(2), MAPK8(4), NFKBIB(4), TP53(75) 4011622 137 89 111 15 40 2 43 11 41 0 0.00187 3.78e-09 2.12e-07 12 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(19), CDC25A(1), CDK2(1), CDK4(2), CHEK1(1), MYT1(3), RB1(19), TP53(75), WEE1(2) 3385655 123 79 96 13 35 3 38 9 38 0 0.00144 2.66e-08 1.37e-06 13 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(4), ATM(19), ATR(3), CCNA1(1), CCND1(1), CDC25A(1), CDK2(1), CDK4(2), CDK6(1), CDKN1A(18), CDKN1B(5), CDKN2A(8), CDKN2B(2), E2F1(1), HDAC1(1), RB1(19), SKP2(1), TGFB3(1), TP53(75) 5799044 164 93 136 15 47 3 45 9 60 0 5.10e-05 2.93e-08 1.39e-06 14 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(19), ATR(3), CHEK1(1), CHEK2(5), TP53(75) 3083402 103 77 78 10 35 1 37 7 23 0 0.00597 6.36e-08 2.80e-06 15 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT3(1), CDKN1A(18), HRAS(6), MAP2K1(1), NGFR(3), NTRK1(4), PIK3CA(26), PIK3CD(3), SOS1(5) 3134093 67 51 50 6 36 2 9 5 15 0 0.00327 3.58e-06 0.000147 16 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CDK2(1), CDKN1B(5), CUL1(8), E2F1(1), RB1(19), SKP2(1) 1653355 35 29 32 3 12 1 2 1 19 0 0.0292 6.73e-06 0.000259 17 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(1), CDK2(1), CUL1(8), E2F1(1), RB1(19), SKP2(1) 1645498 31 28 28 2 10 1 3 1 16 0 0.0189 7.48e-06 0.000271 18 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(1), CDK7(3), CDKN1A(18), CHEK1(1), WEE1(2) 1317025 25 22 24 3 5 1 2 0 17 0 0.648 0.000186 0.00637 19 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), RB1(19), SP1(3), SP3(2) 1277699 25 21 23 3 6 1 0 2 16 0 0.177 0.000514 0.0160 20 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 EGFR(3), IGF1R(5), MYC(1), PPP2CA(1), PRKCA(1), RB1(19), TEP1(4), TERT(1), TNKS(2), TP53(75), XRCC5(1) 5442110 113 73 86 13 27 2 40 9 35 0 0.000137 0.000520 0.0160 21 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(4), FOS(3), HRAS(6), KLK2(1), MAP2K1(1), MAPK3(3), MAPK8(4), NGFR(3), PIK3CA(26), PIK3R1(2), PLCG1(3), RAF1(1), SOS1(5) 3695372 62 46 46 5 40 3 8 8 3 0 0.000742 0.00239 0.0702 22 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(1), CDKN1A(18), EPOR(1), GRIN1(6), HIF1A(1), JAK2(2), NFKB1(1), NFKBIA(2), RELA(2) 2440672 34 30 33 4 11 0 5 1 17 0 0.253 0.00371 0.104 23 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 APAF1(1), ATM(19), BAX(1), BCL2L1(2), CASP3(1), CASP6(1), CASP9(3), PRKCA(1), PTK2(3), STAT1(4), TLN1(2), TP53(75) 5290049 113 79 88 15 36 1 41 9 26 0 0.00436 0.00555 0.149 24 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(7), CDH1(6), CREBBP(18), EP300(26), MAP2K1(1), MAP3K7(3), MAPK3(3), SKIL(5), TGFB3(1), TGFBR2(3) 4959453 73 51 72 7 27 2 13 8 23 0 0.00906 0.00832 0.214 25 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(18), EP300(26), MAPK3(3), PELP1(2), SRC(4) 2840672 53 44 52 9 17 2 13 6 15 0 0.103 0.0126 0.310 26 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR3(1), ARPC2(3), ARPC4(1), PDGFRA(7), PIK3CA(26), PIK3R1(2), RAC1(1), WASL(1) 2589258 42 37 27 4 30 2 6 3 1 0 0.0171 0.0219 0.518 27 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(2), RXRA(12) 1050905 14 13 8 2 7 2 3 1 1 0 0.139 0.0425 0.969 28 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(4), ATM(19), BRCA1(4), CDKN1A(18), CHEK1(1), CHEK2(5), GADD45A(1), MAPK8(4), MRE11A(2), NFKB1(1), NFKBIA(2), RAD50(6), RAD51(3), RBBP8(2), RELA(2), TP53(75), TP73(2) 5751595 151 93 125 18 50 1 47 10 43 0 0.00870 0.0564 1.000 29 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(2), MTMR1(2), MTMR2(3), MTMR6(4), NFS1(3), THTPA(1), TPK1(2) 1240248 17 14 17 0 12 0 1 1 3 0 0.0192 0.0682 1.000 30 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 HBXIP(1), HRAS(6), PTK2B(3), SOS1(5), SRC(4) 1703738 19 16 18 1 12 0 7 0 0 0 0.0304 0.116 1.000 31 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD3E(1), CD86(1), HLA-DRA(1), HLA-DRB1(1), ICOS(2), ITK(2), LCK(1), PIK3CA(26), PIK3R1(2) 2473405 37 29 22 4 25 2 5 4 1 0 0.0268 0.122 1.000 32 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(4), EGFR(3), ERBB3(14), NRG1(5) 1986130 26 25 22 4 10 2 10 4 0 0 0.160 0.136 1.000 33 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(18), EP300(26), LPL(1), NCOA1(10), NCOA2(4), PPARG(3), RXRA(12) 3561380 74 57 67 11 28 4 17 6 19 0 0.0555 0.175 1.000 34 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(2), CREBBP(18), EP300(26), NCOA3(5), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), RARA(3), RXRA(12) 3995136 73 52 66 11 26 6 17 7 17 0 0.0351 0.178 1.000 35 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 HRAS(6), KLK2(1), NTRK1(4), PIK3CA(26), PIK3R1(2), PLCG1(3), PRKCA(1), SOS1(5) 3016106 48 41 32 6 33 2 7 5 1 0 0.0175 0.183 1.000 36 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(3), HLA-DRA(1), HLA-DRB1(1) 588486 5 5 5 1 0 0 3 1 1 0 0.618 0.185 1.000 37 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(3), IL8(1) 331437 4 4 4 0 2 0 0 0 2 0 0.401 0.186 1.000 38 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(1), CCND1(1), CCNE2(1), CDK2(1), CDK4(2), CDKN1B(5), CDKN2A(8), E2F1(1), E2F2(1), E2F4(1), PRB1(1) 1724381 23 18 23 4 10 0 4 1 8 0 0.253 0.208 1.000 39 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(2), GBA(2), GBA3(2), LPO(4), MPO(2), PRDX6(4), TPO(9) 1614846 25 21 24 4 10 0 9 3 3 0 0.105 0.217 1.000 40 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 CASP9(3), CHUK(6), GHR(2), NFKB1(1), NFKBIA(2), PDPK1(1), PIK3CA(26), PIK3R1(2), PPP2CA(1), RELA(2) 2725835 46 35 31 6 30 2 6 2 6 0 0.0523 0.227 1.000 41 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), IFNG(1), JAK1(3), JAK2(2), PLA2G2A(1), PTPRU(4), REG1A(3), STAT1(4) 2213957 19 18 19 1 11 0 4 2 2 0 0.0269 0.230 1.000 42 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 CAT(3), GHR(2), HRAS(6), IGF1R(5), PIK3CA(26), PIK3R1(2), SOD1(2) 2571051 46 40 30 8 28 2 8 5 3 0 0.0792 0.258 1.000 43 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 CHRNG(1), MUSK(2), PIK3CA(26), PIK3R1(2), PTK2(3), PTK2B(3), SRC(4), TERT(1) 3159016 42 36 27 6 30 3 6 2 1 0 0.0156 0.258 1.000 44 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 BCL2L1(2), CASP9(3), CHUK(6), H2AFX(2), HRAS(6), MAP2K1(1), MAPK3(3), NFKB1(1), PIK3CA(26), PIK3R1(2), RAC1(1), RAF1(1), RALBP1(1), RALGDS(2), RELA(2), RHOA(5) 3688762 64 46 48 9 38 2 9 6 9 0 0.0233 0.259 1.000 45 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(3), GNAS(4), GNB1(5), PRKAR1A(1) 1281408 13 11 13 2 6 2 2 1 2 0 0.262 0.291 1.000 46 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(2), IFNG(1), IL12B(2) 572591 5 5 5 0 1 0 2 0 2 0 0.287 0.293 1.000 47 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(4), FOS(3), HRAS(6), IGF1R(5), IRS1(3), MAP2K1(1), MAPK3(3), MAPK8(4), PIK3CA(26), PIK3R1(2), RAF1(1), RASA1(4), SOS1(5) 4786325 67 52 51 9 41 3 9 9 5 0 0.0128 0.300 1.000 48 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(3), RAB11A(1), RAB3A(1), RAB5A(1) 819403 6 6 6 0 2 2 0 1 1 0 0.254 0.304 1.000 49 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(1), COQ3(1), COQ5(2), COQ6(2), NDUFA12(1), NDUFA13(2) 772198 9 9 9 2 5 1 2 0 1 0 0.530 0.311 1.000 50 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(1), CALM2(1), CDKN1A(18), MARCKS(1), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKCA(1), SP1(3), SP3(2), SYT1(2) 4043967 55 42 54 9 21 3 5 6 20 0 0.231 0.312 1.000 51 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(1), IFNGR2(2), JAK1(3), JAK2(2), STAT1(4) 1580572 12 12 12 1 5 1 1 2 3 0 0.176 0.321 1.000 52 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(1), CDK5R1(1), EGR1(1), HRAS(6), KLK2(1), MAP2K1(1), MAPK3(3), NGFR(3), RAF1(1) 1589377 18 15 17 3 6 1 5 4 2 0 0.193 0.331 1.000 53 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(2), ANXA1(1), CALM1(1), CALM2(1), GNAS(4), GNB1(5), NFKB1(1), NOS3(6), NR3C1(1), PIK3CA(26), PIK3R1(2), RELA(2), SYT1(2) 3465170 54 44 39 8 36 4 5 5 4 0 0.0603 0.341 1.000 54 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 CXCR4(2), GNAI1(1), GNB1(5), HRAS(6), MAP2K1(1), MAPK3(3), NFKB1(1), PIK3C2G(3), PIK3CA(26), PIK3R1(2), PLCG1(3), PRKCA(1), PTK2(3), PTK2B(3), RAF1(1), RELA(2) 5321300 63 47 47 5 42 4 8 7 2 0 0.000288 0.351 1.000 55 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(2), GBA3(2), LPO(4), MPO(2), PRDX1(2), PRDX2(4), PRDX5(1), PRDX6(4), TPO(9), TYR(3) 1859703 33 24 32 6 16 0 11 2 4 0 0.0856 0.399 1.000 56 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SEC61A2(1), SRP19(3), SRP54(1), SRP68(8), SRP72(1), SRP9(1), SRPR(3) 1458879 18 16 18 3 8 0 3 2 5 0 0.336 0.419 1.000 57 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(18), EP300(26), FYN(1), IL2RG(3), IL7(1), IL7R(2), JAK1(3), JAK3(3), LCK(1), PIK3CA(26), PIK3R1(2), PTK2B(3), STAT5B(2) 5396684 91 67 75 15 46 4 15 9 17 0 0.0158 0.431 1.000 58 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 PIK3CA(26), PIK3R1(2), PLCB1(4), PLCG1(3), PRKCA(1), VAV1(2) 2480885 38 35 23 6 26 2 3 5 2 0 0.0935 0.435 1.000 59 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(3), ARHGEF1(6), F2R(2), F2RL3(1), GNA13(5), GNAI1(1), GNB1(5), MAP3K7(3), PIK3CA(26), PIK3R1(2), PLCB1(4), PPP1R12B(2), PRKCA(1), PTK2B(3), ROCK1(4) 4988677 68 45 52 8 44 4 5 7 8 0 0.00465 0.444 1.000 60 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(1), CYP2C9(2) 390328 3 3 3 1 2 0 1 0 0 0 0.686 0.471 1.000 61 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(1), IL6(2), IL6R(1), JAK1(3), JAK2(2), JAK3(3), PIAS3(1), PTPRU(4), REG1A(3), SRC(4) 2958697 24 20 24 2 14 1 6 2 1 0 0.0173 0.479 1.000 62 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(2), DHRS1(1), DHRS7(2), DHRSX(3), LCMT2(1), METTL2B(1), PRMT5(3), PRMT6(1), PRMT7(5), PRMT8(4), WBSCR22(3) 2911761 26 24 25 3 13 2 5 5 1 0 0.0400 0.489 1.000 63 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD4(1), HLA-DRA(1), HLA-DRB1(1) 458593 3 3 3 1 1 0 2 0 0 0 0.697 0.534 1.000 64 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(3), GABARAP(1), GABRA1(1), GABRA2(1), GABRA3(1), GABRA4(5), GABRA5(3), GABRA6(3), GPHN(1), NSF(1), SRC(4) 2294116 24 20 24 4 10 2 8 2 2 0 0.168 0.552 1.000 65 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(1), GABRA2(1), GABRA3(1), GABRA4(5), GABRA5(3), GABRA6(3), SOD1(2) 1509277 16 15 16 4 5 1 6 2 2 0 0.438 0.567 1.000 66 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(3), CASP1(2), CASP3(1), CASP8(4), INSR(4), ITCH(5), MAGI1(4), MAGI2(7), RERE(8), WWP1(2), WWP2(2) 4648148 42 33 41 4 22 1 9 5 5 0 0.0134 0.581 1.000 67 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(4), ST3GAL1(1), ST3GAL5(2), ST6GALNAC4(1), ST8SIA1(1) 1093542 9 8 9 2 3 0 1 3 2 0 0.403 0.594 1.000 68 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(15), MAP2(5), PPP1CA(4), PPP2CA(1), PRKACB(1), PRKAG1(2), PRKAR2A(3), PRKAR2B(1) 3498828 32 23 32 2 21 2 4 2 3 0 0.0368 0.602 1.000 69 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(3), GAD1(5), HDC(2) 1161532 10 9 10 2 4 0 2 1 3 0 0.449 0.619 1.000 70 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(2), CTSD(3), GREB1(5), HSPB2(2), MTA1(2), PDZK1(1), TUBA8(1) 2114916 16 14 16 2 4 1 10 0 1 0 0.0793 0.650 1.000 71 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(1), GNB1(5), HTR2C(1), PLCB1(4), TUB(1) 1378016 12 10 12 2 5 2 2 2 1 0 0.296 0.658 1.000 72 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(2), CYP2E1(1), NR1I3(2), PTGS2(2) 1033131 7 6 7 1 5 0 1 0 1 0 0.248 0.681 1.000 73 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK1(3), JAK2(2), JAK3(3), PIAS3(1), PTPRU(4), REG1A(3), SOAT1(4) 2652266 21 19 21 3 13 1 4 2 1 0 0.104 0.687 1.000 74 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(1), FUT1(2), FUT2(1), FUT3(1), FUT5(1) 977979 6 6 6 0 1 0 5 0 0 0 0.119 0.706 1.000 75 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1), GLS2(1), GLUD1(2), GLUD2(3) 879132 7 6 7 2 2 0 3 0 2 0 0.721 0.709 1.000 76 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(1) 220138 1 1 1 1 1 0 0 0 0 0 0.934 0.713 1.000 77 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(2), PDXK(3), PNPO(2), PSAT1(1) 937306 8 8 8 4 3 0 0 1 4 0 0.899 0.723 1.000 78 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(1), GALT(1), UGDH(2), UGP2(5) 947897 9 9 8 2 6 0 1 1 1 0 0.530 0.733 1.000 79 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(3), AOC3(1), ESD(2) 1163257 6 6 6 0 2 0 3 1 0 0 0.155 0.734 1.000 80 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CLOCK(1), CRY1(1), CRY2(3), CSNK1E(1), PER1(3) 1637148 9 9 9 1 2 0 4 1 2 0 0.416 0.763 1.000 81 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(5), ANAPC2(3), ANAPC4(3), ANAPC5(1), ANAPC7(2), CDC16(1), CDC27(3), CUL1(8), CUL2(4), CUL3(1), FBXW11(1), FBXW7(16), FZR1(2), ITCH(5), SKP1(1), SKP2(1), SMURF1(4), SMURF2(1), UBA1(1), UBE2C(1), UBE2D3(1), WWP1(2), WWP2(2) 7749748 69 45 64 6 30 6 13 5 15 0 0.00408 0.776 1.000 82 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(1), HLA-A(5), ITGB1(1), KLRC4(2), KLRD1(1), LAT(1), MAP2K1(1), MAPK3(3), PIK3CA(26), PIK3R1(2), PTK2B(3), RAC1(1), SYK(1), VAV1(2) 3589380 50 42 34 9 31 2 5 5 7 0 0.127 0.783 1.000 83 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(3), FOSL1(1), FOSL2(3), IFNAR1(1), IFNAR2(1), MAPK8(4), NFKB1(1), RELA(2), TNFSF11(1), TRAF6(1) 2142418 18 15 18 3 8 0 4 1 5 0 0.348 0.787 1.000 84 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(1), IDI2(3) 820497 4 4 4 0 1 0 2 1 0 0 0.355 0.795 1.000 85 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(1), B3GALT5(1), B3GNT5(6), FUT1(2), FUT2(1), FUT3(1) 1391160 12 8 12 1 7 0 5 0 0 0 0.0810 0.803 1.000 86 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(3), CD3E(1), CD4(1), CREBBP(18), CSK(4), GNAS(4), GNB1(5), HLA-DRA(1), HLA-DRB1(1), LCK(1), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PTPRC(5), ZAP70(1) 4429484 52 37 51 9 21 4 13 3 11 0 0.0532 0.804 1.000 87 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(3), CD3E(1), CD4(1), CREBBP(18), CSK(4), GNAS(4), GNB1(5), HLA-DRA(1), HLA-DRB1(1), LCK(1), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PTPRC(5), ZAP70(1) 4429484 52 37 51 9 21 4 13 3 11 0 0.0532 0.804 1.000 88 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(2), DAG1(1), ITPKA(2), ITPKB(1) 1165072 6 6 6 1 4 0 1 1 0 0 0.434 0.806 1.000 89 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(1) 407844 1 1 1 0 0 0 1 0 0 0 0.762 0.810 1.000 90 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(3), ACTR3(1), ARPC2(3), ARPC4(1), RAC1(1), WASL(1) 1568083 10 9 10 1 7 1 1 1 0 0 0.262 0.811 1.000 91 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), HADH(1), HADHA(3), HADHB(2), HSD17B10(1), HSD17B4(3), MECR(1), PPT2(1) 1636994 13 9 13 0 10 1 0 1 1 0 0.0238 0.815 1.000 92 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2) 1088874 8 8 8 2 5 0 2 1 0 0 0.535 0.821 1.000 93 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(1), GNAS(4), GNB1(5), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(1) 1861490 18 11 18 2 8 3 4 2 1 0 0.138 0.824 1.000 94 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(1), B3GNT1(1), FUT1(2), FUT2(1), FUT9(1), GCNT2(1), ST8SIA1(1) 1180654 8 7 8 2 2 0 4 2 0 0 0.480 0.828 1.000 95 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 HRAS(6), IGF1R(5), IRS1(3), MAP2K1(1), MAPK3(3), PIK3CA(26), PIK3R1(2), RAF1(1), SOS1(5) 3672172 52 43 36 9 34 2 6 7 3 0 0.0824 0.829 1.000 96 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 CAT(3), EPX(2), LPO(4), MPO(2), PRDX1(2), PRDX2(4), PRDX5(1), PRDX6(4), SHMT1(1), TPO(9) 2280013 32 24 31 5 18 0 8 3 3 0 0.0408 0.831 1.000 97 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(2), CHPT1(2), LCMT2(1), METTL2B(1), PCYT1A(1), PRMT5(3), PRMT6(1), PRMT7(5), PRMT8(4), WBSCR22(3) 2722705 23 22 22 4 13 2 3 5 0 0 0.187 0.839 1.000 98 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(3), TYR(3) 908525 6 6 6 2 3 0 3 0 0 0 0.653 0.847 1.000 99 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(1), CREBBP(18), DFFA(4), GZMA(4), HMGB2(4), PRF1(4) 2040378 35 30 34 9 15 0 11 2 7 0 0.401 0.884 1.000 100 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 CTH(2), MUT(1) 946870 3 3 3 0 1 1 1 0 0 0 0.474 0.887 1.000 101 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), BIRC3(1), CASP8(4), FADD(1), RIPK1(2), TNFRSF1B(3), TRADD(1), TRAF2(2) 1622003 15 14 15 3 8 0 4 2 1 0 0.328 0.887 1.000 102 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(3), CD4(1), HLA-DRA(1), HLA-DRB1(1), IL1B(1), IL5RA(2), IL6(2) 1032374 11 11 11 4 5 0 3 2 1 0 0.670 0.889 1.000 103 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA5(1), NDUFA8(1), NDUFB5(1), NDUFB6(1), NDUFS1(2), NDUFS2(1), NDUFV1(2) 1345812 9 9 9 2 3 0 4 1 1 0 0.547 0.891 1.000 104 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), LDLR(2), MBTPS1(4), SCAP(3), SREBF1(4), SREBF2(2) 2309312 16 15 16 3 7 0 5 2 2 0 0.235 0.892 1.000 105 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACAT1(1), HADHA(3) 1044366 4 4 4 1 3 0 0 0 1 0 0.753 0.895 1.000 106 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5O(1), ATP6V0A1(6), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(6), ATP6V1C1(3), ATP6V1E1(1), ATP6V1G2(1), ATP6V1H(4), FDXR(3), SHMT1(1) 3098582 33 26 33 6 15 3 6 5 4 0 0.0960 0.898 1.000 107 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(4), EGFR(3), MAP2K1(1), MAP3K1(3), MAPK14(1), NCOR2(10), RARA(3), RXRA(12) 3347403 37 35 31 8 14 2 13 4 4 0 0.229 0.899 1.000 108 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(1), CSF1(2), IL6(2), LDLR(2), LPL(1) 1029629 8 8 8 3 4 0 2 0 2 0 0.772 0.902 1.000 109 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(1), FMOD(1), KERA(2) 697527 4 4 4 2 2 0 2 0 0 0 0.808 0.903 1.000 110 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(1), NFKBIA(2), PLCB1(4), PRKCA(1), RELA(2) 1590882 10 9 10 2 4 0 2 3 1 0 0.463 0.906 1.000 111 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(1), ACAA2(1), ACAT1(1), EHHADH(1), HADHA(3), HADHB(2), SDS(1) 1617062 10 8 10 1 9 0 0 0 1 0 0.231 0.906 1.000 112 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(2), CYP2A13(3), CYP2A6(3), CYP2A7(3), NAT1(2), XDH(6) 1543255 19 19 19 5 8 0 4 4 3 0 0.338 0.907 1.000 113 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD3E(1), CD8A(2), ICAM1(3), ITGAL(2), ITGB2(3), PTPRC(5) 2069086 17 16 17 4 7 1 4 2 3 0 0.283 0.917 1.000 114 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6V0A1(6), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(6), ATP6V1C1(3), ATP6V1E1(1), ATP6V1G2(1), ATP6V1H(4), SHMT1(1) 2910134 30 24 30 6 12 3 6 5 4 0 0.163 0.918 1.000 115 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6V0A1(6), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(6), ATP6V1C1(3), ATP6V1E1(1), ATP6V1G2(1), ATP6V1H(4), SHMT1(1) 2910134 30 24 30 6 12 3 6 5 4 0 0.163 0.918 1.000 116 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6V0A1(6), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(6), ATP6V1C1(3), ATP6V1E1(1), ATP6V1G2(1), ATP6V1H(4), SHMT1(1) 2910134 30 24 30 6 12 3 6 5 4 0 0.163 0.918 1.000 117 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP3(1), CASP8(4), CFLAR(1) 748523 6 6 6 2 3 0 1 1 1 0 0.694 0.918 1.000 118 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP3(1), DFFA(4), HMGB1(1), HMGB2(4), TOP2A(7), TOP2B(2) 1704993 19 18 19 4 14 0 2 1 2 0 0.597 0.919 1.000 119 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(1), BAX(1), BCL2L1(2), BIRC3(1), CASP3(1), CASP6(1), CASP8(4), CASP9(3), FADD(1), MAP2K4(1), MAP3K1(3), MAP3K14(2), MAPK10(1), MCL1(1), MYC(1), NFKB1(1), NFKBIA(2), PARP1(5), PRF1(4), RELA(2), RIPK1(2), TNFRSF1B(3), TNFSF10(2), TP53(75), TRADD(1), TRAF2(2) 7236114 123 78 98 22 39 2 49 9 24 0 0.0179 0.924 1.000 120 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(1) 653008 1 1 1 2 0 0 0 0 1 0 1.000 0.924 1.000 121 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(1), GLS(1), GLUD1(2), PRODH(1) 1074281 5 4 5 1 3 1 1 0 0 0 0.589 0.924 1.000 122 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(1), JUNB(4), MAF(1), MAP2K3(2), MAPK14(1), NFATC1(4), NFATC2(6), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1) 2347929 26 18 26 5 9 3 6 3 5 0 0.164 0.926 1.000 123 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(1), SNAP25(1) 629498 2 2 2 0 2 0 0 0 0 0 0.470 0.928 1.000 124 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 CAT(3), EPX(2), LPO(4), MPO(2), MTHFR(1), PRDX6(4), SHMT1(1), TPO(9) 2243863 26 21 25 5 13 0 8 3 2 0 0.134 0.939 1.000 125 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT3(1), BPNT1(2), MAPK3(3), PIK3CA(26), PIK3CD(3), PTEN(5), PTK2B(3), RBL2(3), SOS1(5) 3941926 51 41 36 9 39 2 3 4 3 0 0.0975 0.941 1.000 126 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(2), CYP11A1(1), CYP11B2(3), CYP21A2(1), HSD3B1(2), HSD3B2(3) 1793052 13 10 13 3 6 0 5 2 0 0 0.289 0.947 1.000 127 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(2), CYP11A1(1), CYP11B2(3), CYP21A2(1), HSD3B1(2), HSD3B2(3) 1793052 13 10 13 3 6 0 5 2 0 0 0.289 0.947 1.000 128 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(2), GGT1(1), SHMT1(1) 794800 4 4 4 3 1 0 1 0 2 0 0.947 0.949 1.000 129 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOA(2) 756956 2 2 2 1 2 0 0 0 0 0 0.792 0.956 1.000 130 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(1), CDK5R1(1), GRM1(7), PLCB1(4), PPP1CA(4), PPP1R1B(1), PPP2CA(1), PPP3CA(4), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1) 3096119 30 22 30 6 10 2 7 6 5 0 0.229 0.959 1.000 131 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(6), CREBBP(18), EP300(26), FADD(1), IKBKB(4), NFKB1(1), NFKBIA(2), RELA(2), RIPK1(2), TNFRSF1B(3), TRADD(1), TRAF6(1) 4322882 67 50 66 13 24 2 15 6 20 0 0.143 0.960 1.000 132 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(1), CD3E(1), HLA-A(5), ICAM1(3), ITGAL(2), ITGB2(3), PRF1(4) 1692530 19 18 18 6 7 0 6 2 4 0 0.486 0.965 1.000 133 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 MAP2K1(1), MAP2K3(2), MAP3K1(3), MAPK14(1), MAPK3(3), NFKB1(1), PIK3CA(26), PIK3R1(2), RB1(19), RELA(2), SP1(3) 3746001 63 48 46 11 30 4 4 6 19 0 0.130 0.967 1.000 134 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(3), ADCY1(3), CAP1(5), CCNB1(1), GNAI1(1), GNAS(4), GNB1(5), HRAS(6), MAPK3(3), MYT1(3), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), RPS6KA1(1), SRC(4) 3990128 46 33 45 8 20 4 13 5 4 0 0.0619 0.968 1.000 135 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(1), ALAS1(5), FECH(1), PPOX(4), UROD(1), UROS(2) 1462080 14 13 14 6 6 0 3 1 4 0 0.865 0.968 1.000 136 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(4), FOS(3), HRAS(6), INSR(4), IRS1(3), MAP2K1(1), MAPK3(3), MAPK8(4), PIK3CA(26), PIK3R1(2), RAF1(1), RASA1(4), SLC2A4(1), SOS1(5) 4918083 67 51 51 11 43 3 9 8 4 0 0.0329 0.968 1.000 137 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 EHHADH(1), HADHA(3), SDS(1) 936834 5 5 5 2 5 0 0 0 0 0 0.695 0.969 1.000 138 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(4), FOS(3), HRAS(6), JAK1(3), MAP2K1(1), MAP2K4(1), MAP3K1(3), MAPK3(3), MAPK8(4), PDGFRA(7), PIK3CA(26), PIK3R1(2), PLCG1(3), PRKCA(1), RAF1(1), RASA1(4), SOS1(5), STAT1(4) 6743397 81 61 65 11 48 4 14 10 5 0 0.00485 0.970 1.000 139 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(1), IL10RA(4), IL10RB(3), IL1A(1), IL6(2), JAK1(3), STAT1(4) 2364136 18 15 18 4 9 0 0 3 6 0 0.243 0.971 1.000 140 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR2(1), GPR161(3), GPR171(1), GPR39(2), GPR45(3), GPR65(1), GPR68(2), GPR75(6), GPR81(3) 1894848 22 17 22 7 10 0 5 3 4 0 0.327 0.972 1.000 141 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(1), ALAS1(5), FECH(1), GATA1(4), UROD(1), UROS(2) 1509673 14 11 14 6 6 1 2 1 4 0 0.851 0.972 1.000 142 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(1), EHHADH(1), GCDH(2), HADHA(3), SDS(1) 1510121 8 7 8 2 7 0 0 0 1 0 0.587 0.972 1.000 143 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 FOS(3), KEAP1(5), MAFF(1), MAFK(1), MAPK14(1), MAPK8(4), NFE2L2(12), PRKCA(1) 1716321 28 19 25 7 13 1 6 5 3 0 0.436 0.972 1.000 144 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(1), CYP11A1(1), CYP11B2(3), HSD3B1(2), HSD3B2(3) 1337035 10 8 10 3 6 0 4 0 0 0 0.352 0.973 1.000 145 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(3), ADRB2(2), CFTR(2), GNAS(4), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1) 2527486 18 15 18 4 7 1 5 2 3 0 0.375 0.974 1.000 146 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(3), ASAH1(2), GNAI1(1), GNB1(5), ITGAV(3), ITGB3(2), MAPK3(3), PDGFRA(7), PIK3CA(26), PIK3R1(2), PLCB1(4), PRKCA(1), PTK2(3), RAC1(1), SMPD1(3), SMPD2(2), SRC(4) 5308686 72 55 57 13 43 4 12 9 4 0 0.0390 0.975 1.000 147 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), FLT3(3), IL1A(1), IL6(2), KITLG(2), TGFB3(1) 1611076 10 10 10 3 7 0 0 1 2 0 0.591 0.976 1.000 148 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 HLCS(3) 593573 3 3 3 2 3 0 0 0 0 0 0.848 0.980 1.000 149 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNG(1), IL12B(2), IL16(2), IL1A(1), IL6(2), IL8(1) 1910836 9 9 9 2 5 0 3 0 1 0 0.377 0.981 1.000 150 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(19), ATR(3), BRCA1(4), CCNB1(1), CDC25A(1), CDKN1A(18), CDKN2D(1), CHEK1(1), CHEK2(5), EP300(26), GADD45A(1), MYT1(3), PRKDC(10), RPS6KA1(1), TP53(75), WEE1(2), YWHAQ(1) 8079041 172 92 146 27 53 6 51 13 49 0 0.0474 0.981 1.000 151 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(1) 611494 1 1 1 0 1 0 0 0 0 0 0.747 0.984 1.000 152 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(1), FOSB(1), GRIA2(3), JUND(1), PPP1R1B(1) 720820 7 7 7 3 5 0 0 1 1 0 0.838 0.984 1.000 153 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(2), ARFGAP3(3), ARFGEF2(4), CLTB(1), COPA(5), GBF1(8), GPLD1(4) 3142494 27 21 27 5 18 2 4 1 2 0 0.153 0.985 1.000 154 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(2), FDPS(1), HMGCR(1), HMGCS1(1), LSS(3), NSDHL(1), PMVK(1), SC4MOL(4), SC5DL(1) 2550982 15 12 15 3 9 2 1 3 0 0 0.308 0.985 1.000 155 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(3), BAX(1), BCL2L1(2), CSF2RB(1), IGF1R(5), IL3RA(3), KIT(3), KITLG(2), PIK3CA(26), PIK3R1(2), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1) 4244839 55 41 40 11 29 4 7 6 9 0 0.0695 0.985 1.000 156 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(1), GBA(2), GBA3(2), GGT1(1), SHMT1(1) 1057334 7 7 7 5 2 0 2 1 2 0 0.961 0.987 1.000 157 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(3), ALDH3A1(2), ALDH3B1(2), AOC3(1), DDC(3), EPX(2), HPD(2), LPO(4), MAOA(1), MPO(2), PRDX1(2), PRDX2(4), PRDX5(1), PRDX6(4), TPO(9) 4244493 42 32 41 7 23 0 12 3 4 0 0.0165 0.987 1.000 158 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CEBPB(3), CSNK2A1(4), FOS(3), HRAS(6), IL6(2), IL6R(1), IL6ST(3), JAK1(3), JAK2(2), JAK3(3), MAP2K1(1), MAPK3(3), RAF1(1), SOS1(5) 4619426 40 32 39 6 21 1 6 8 4 0 0.0586 0.988 1.000 159 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(3), GNAS(4), GNB1(5), PPP2CA(1), PRKAA2(4), PRKAB2(1), PRKACB(1), PRKAG1(2), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1) 2974081 27 19 27 5 10 4 8 1 4 0 0.230 0.989 1.000 160 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ASL(3), CPS1(4), GLS(1), GLUD1(2) 1500433 10 6 10 3 7 0 2 0 1 0 0.606 0.989 1.000 161 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), CSAD(1), GAD1(5), GGT1(1) 1112933 8 8 8 8 4 0 2 0 2 0 0.992 0.990 1.000 162 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(7), AGT(1), AGTR2(1), KNG1(1), NOS3(6), REN(2) 1919184 18 17 17 5 11 0 6 0 1 0 0.271 0.991 1.000 163 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(13), ACACB(5), FASN(2), MCAT(1), OXSM(2) 3092336 23 22 22 5 16 1 1 3 2 0 0.217 0.991 1.000 164 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(4), FOS(3), HRAS(6), IL2RA(1), IL2RB(2), IL2RG(3), JAK1(3), JAK3(3), LCK(1), MAP2K1(1), MAPK3(3), MAPK8(4), RAF1(1), SOS1(5), STAT5B(2), SYK(1) 4508007 43 34 42 9 20 1 11 8 3 0 0.130 0.992 1.000 165 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(4), FOS(3), HRAS(6), JAK2(2), MAP2K1(1), MAPK3(3), MPL(1), PIK3CA(26), PIK3R1(2), PLCG1(3), PRKCA(1), RAF1(1), RASA1(4), SOS1(5), STAT1(4), STAT5B(2), THPO(1) 5788178 69 53 53 10 45 4 8 8 4 0 0.0163 0.992 1.000 166 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(3), PRKCA(1), PTK2B(3) 1297367 8 8 8 3 6 0 1 1 0 0 0.614 0.992 1.000 167 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(1), GALT(1), UGDH(2) 744595 4 4 4 2 2 0 1 1 0 0 0.861 0.993 1.000 168 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(1), P2RY1(1), P2RY2(1) 1152233 3 3 3 2 2 0 0 1 0 0 0.753 0.994 1.000 169 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(1), APOA2(1), CD36(1), CITED2(1), CPT1B(2), CREBBP(18), DUT(1), EHHADH(1), EP300(26), HSD17B4(3), HSPA1A(2), LPL(1), MAPK3(3), ME1(2), MRPL11(1), MYC(1), NCOA1(10), NCOR1(13), NCOR2(10), NFKBIA(2), NR2F1(2), NRIP1(4), PIK3CA(26), PIK3R1(2), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(1), PTGS2(2), RB1(19), RELA(2), RXRA(12), SP1(3), STAT5B(2) 12210636 182 86 158 29 78 9 31 19 45 0 0.00105 0.994 1.000 170 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(4), EGF(4), EGFR(3), FOS(3), HRAS(6), JAK1(3), MAP2K1(1), MAP2K4(1), MAP3K1(3), MAPK3(3), MAPK8(4), PIK3CA(26), PIK3R1(2), PLCG1(3), PRKCA(1), RAF1(1), RASA1(4), SOS1(5), STAT1(4) 7238534 81 60 65 12 49 4 13 10 5 0 0.0106 0.994 1.000 171 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(1), B4GALT1(1), FUT8(5), ST3GAL1(1) 1522294 8 8 8 3 4 0 1 3 0 0 0.698 0.994 1.000 172 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(3), POLD2(3), POLE(6), POLQ(8) 3244322 20 17 20 4 12 0 3 1 4 0 0.250 0.995 1.000 173 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(1), ACOX3(3), FADS2(1), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1) 1963243 13 12 13 4 5 0 3 3 2 0 0.567 0.995 1.000 174 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(1), ACOX1(1), ACOX3(3), ELOVL5(1), ELOVL6(1), FADS1(2), FADS2(1), FASN(2), HADHA(3), SCD(1) 2805082 16 14 16 4 10 0 3 1 2 0 0.280 0.996 1.000 175 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD4(1), HLA-DRA(1), HLA-DRB1(1) 767428 3 3 3 2 1 0 2 0 0 0 0.866 0.996 1.000 176 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 ABO(1), B3GNT1(1), B3GNT2(2), B3GNT4(1), B3GNT5(6), B4GALT1(1), FUT1(2), FUT2(1), FUT3(1), FUT5(1), FUT9(1), GCNT2(1), ST3GAL6(2), ST8SIA1(1) 3112564 22 14 22 4 12 0 5 4 1 0 0.149 0.996 1.000 177 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP2(10), RANGAP1(2) 1625665 13 11 13 3 6 2 2 1 2 0 0.717 0.996 1.000 178 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 HRAS(6), MAPK3(3), MAPK7(2), MEF2A(1), MEF2C(2), MEF2D(1), NTRK1(4), PIK3CA(26), PIK3R1(2), PLCG1(3), RPS6KA1(1) 3666641 51 43 35 10 32 2 12 4 1 0 0.0695 0.996 1.000 179 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 B3GALT5(1), FUT1(2), FUT2(1), FUT9(1), GLA(1), HEXA(1), HEXB(2), NAGA(1), ST3GAL1(1), ST8SIA1(1) 2074499 12 12 12 4 6 0 4 1 1 0 0.570 0.996 1.000 180 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(5), PRKACB(1), PRKAG1(2), PRKAR2A(3), PRKAR2B(1) 1950855 12 8 12 3 8 1 1 0 2 0 0.560 0.997 1.000 181 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(6), APOA4(2), APOC1(1), CETP(2), CYP7A1(4), DGAT1(1), HMGCR(1), LCAT(1), LDLR(2), LIPC(5), LPL(1), LRP1(12), SCARB1(1), SOAT1(4) 5300968 43 31 43 8 25 1 8 2 7 0 0.0530 0.997 1.000 182 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(3), F13A1(2), F2R(2), FGA(7), FGB(1), FGG(3), PLAT(1), PLAU(1), SERPINB2(1), SERPINE1(2) 2585938 23 19 23 5 10 0 8 1 4 0 0.356 0.997 1.000 183 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(1), ERBB4(3), NRG3(3), PRKCA(1), PSEN1(5) 1736379 13 13 13 4 6 1 3 1 2 0 0.698 0.997 1.000 184 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(1), ADSS(2), IMPDH1(1), MTHFD2(2), POLD1(3), RRM1(1), SRM(2) 2427855 12 10 12 3 4 1 6 0 1 0 0.519 0.997 1.000 185 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(3), CR2(6), FCGR2B(1), HLA-DRA(1), HLA-DRB1(1), ICAM1(3), ITGAL(2), ITGB2(3), PTPRC(5) 2918637 25 24 25 6 9 2 8 3 3 0 0.342 0.997 1.000 186 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 FDPS(1), HMGCR(1), LSS(3), PMVK(1), SC5DL(1), VKORC1(1) 2139206 8 8 8 2 5 1 1 1 0 0 0.499 0.997 1.000 187 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(3), FHL5(1), FSHR(1), GNAS(4), XPO1(3) 1853617 12 9 12 5 6 0 1 2 3 0 0.855 0.998 1.000 188 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), ENO2(1), ENO3(1), PAH(3), YARS(3) 1606332 10 10 10 6 2 1 3 1 3 0 0.934 0.998 1.000 189 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT1(2), FUT2(1), FUT9(1), GLA(1), HEXA(1), HEXB(2), NAGA(1), ST3GAL1(1), ST8SIA1(1) 1954235 11 11 11 4 6 0 3 1 1 0 0.625 0.998 1.000 190 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(1), CD8A(2), CSF1(2), IL6(2), IL7(1), IL8(1) 1182748 9 9 9 4 6 1 2 0 0 0 0.679 0.998 1.000 191 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(6), ABCB4(3), ABCC1(8), ABCC3(8), GSTP1(2) 2756497 27 22 27 8 15 2 5 4 1 0 0.319 0.998 1.000 192 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 LPL(1), NR3C1(1), PPARG(3), RXRA(12) 1116810 17 17 11 7 9 2 4 1 1 0 0.769 0.998 1.000 193 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(2), IL1B(1), MST1(3), MST1R(5) 1265983 11 10 11 9 5 1 3 1 1 0 0.973 0.999 1.000 194 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(1), CDK5R1(1), DAB1(4), FYN(1), RELN(13), VLDLR(2) 2709901 22 18 22 5 10 2 5 2 3 0 0.458 0.999 1.000 195 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(1), BDH2(2), HMGCS1(1), OXCT2(1) 1392249 5 5 5 4 0 1 2 1 1 0 0.981 0.999 1.000 196 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 F13B(1), HSD17B1(1), HSD17B3(1), HSD17B4(3), HSD3B1(2), HSD3B2(3) 1559341 11 10 11 4 8 0 2 1 0 0 0.666 0.999 1.000 197 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD3E(1), CD4(1), ICAM1(3), ITGAL(2), ITGB2(3), PTPRC(5) 2169711 16 15 16 5 8 0 3 2 3 0 0.460 0.999 1.000 198 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(1), ARHGAP5(8), CASP1(2), CASP3(1), CASP8(4), CASP9(3), PRF1(4) 2492970 23 21 23 9 9 0 6 3 5 0 0.866 0.999 1.000 199 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2) 1544046 7 7 7 6 3 0 1 1 2 0 0.960 0.999 1.000 200 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2) 1544046 7 7 7 6 3 0 1 1 2 0 0.960 0.999 1.000 201 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(1), CD34(2), CD3E(1), CD4(1), CD58(1), CD8A(2), IL6(2), IL8(1), KITLG(2) 1198088 13 12 13 7 7 1 2 1 2 0 0.881 0.999 1.000 202 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(19), ATR(3), BRCA1(4), BRCA2(17), CHEK1(1), CHEK2(5), FANCA(5), FANCC(2), FANCD2(10), FANCE(2), FANCF(2), FANCG(2), HUS1(1), MRE11A(2), RAD1(1), RAD17(1), RAD50(6), RAD51(3), TP53(75) 8504536 161 88 136 24 63 5 45 13 35 0 0.0244 0.999 1.000 203 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(2), ALPL(1), FPGS(1), GCH1(1) 1247548 5 5 5 5 3 0 1 0 1 0 0.955 0.999 1.000 204 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(2), PARK2(2), SNCAIP(3), UBE2L6(1) 1240898 8 7 8 8 3 2 1 1 1 0 0.996 0.999 1.000 205 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(4), AASS(3), KARS(3) 1340895 10 10 10 5 5 1 1 2 1 0 0.934 0.999 1.000 206 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3E(1), IFNG(1), IL2RA(1), TGFB3(1), TGFBR2(3), TGFBR3(7), TOB1(4) 2050270 18 18 18 5 12 0 4 0 2 0 0.526 0.999 1.000 207 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(5), C5(3), C8A(2), C9(5) 2415790 15 14 15 4 6 1 6 1 1 0 0.568 0.999 1.000 208 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(6), IKBKAP(4), IKBKB(4), MAP3K1(3), MAP3K14(2), NFKB1(1), NFKBIA(2), RELA(2), RIPK1(2), TANK(1), TNFAIP3(2), TNFRSF1B(3), TRAF2(2) 4338292 34 30 34 7 16 2 8 2 6 0 0.233 0.999 1.000 209 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(1), BAX(1), BCL10(1), BCL2L1(2), CASP8AP2(7), CASP9(3) 2075485 15 14 15 5 7 0 3 2 3 0 0.813 0.999 1.000 210 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH3A1(2), ALDH9A1(2), UGDH(2) 1647021 6 6 6 5 3 0 0 1 2 0 0.949 0.999 1.000 211 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(2), CAPNS2(1), CDK5(1), CDK5R1(1), CSNK1A1(3), MAPT(5), PPP2CA(1) 1789183 14 11 14 7 6 0 3 2 3 0 0.943 0.999 1.000 212 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), B4GALT7(1), XYLT1(3), XYLT2(2) 1257884 7 7 7 4 4 1 1 1 0 0 0.765 1.000 1.000 213 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), B4GALT7(1), XYLT1(3), XYLT2(2) 1257884 7 7 7 4 4 1 1 1 0 0 0.765 1.000 1.000 214 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 FOS(3), MAPK3(3), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1) 2490456 13 10 13 4 5 1 4 1 2 0 0.573 1.000 1.000 215 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(1), CD36(1), FOS(3), FYN(1), MAPK14(1) 1430515 7 6 7 3 3 0 1 1 2 0 0.815 1.000 1.000 216 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3E(1), CD4(1), FYN(1), HLA-DRA(1), HLA-DRB1(1), LCK(1), PTPRC(5), ZAP70(1) 1735611 12 9 12 5 6 0 3 1 2 0 0.771 1.000 1.000 217 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 CTH(2), DNMT1(4), DNMT3A(1), DNMT3B(1), MAT1A(2), MTR(3) 3367042 13 12 13 3 7 1 2 1 2 0 0.380 1.000 1.000 218 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(1), DLL1(4), FURIN(2), NOTCH1(5), PSEN1(5) 1780063 17 16 17 8 8 1 5 1 2 0 0.883 1.000 1.000 219 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(6), MMP14(1), MMP2(2), MMP9(3), RECK(1) 1457135 13 12 12 8 3 2 7 0 1 0 0.950 1.000 1.000 220 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(3), GNAS(4), GNB1(5), HRAS(6), LIMK1(2), MAP2K1(1), MAPK3(3), MYL2(2), NOX1(1), PIK3C2G(3), PLCB1(4), PPP1R12B(2), PRKCA(1), PTK2(3), RAF1(1), ROCK2(6) 4842671 47 34 46 9 23 2 8 11 3 0 0.208 1.000 1.000 221 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARSA(1), FARSB(2), PAH(3), YARS(3), YARS2(1) 1680288 10 10 10 4 3 1 3 1 2 0 0.744 1.000 1.000 222 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(2), GSS(1), IL8(1), NFKB1(1), NOX1(1), RELA(2), SOD1(2), XDH(6) 1918966 16 14 16 7 7 0 6 0 3 0 0.730 1.000 1.000 223 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(1), BAX(1), BCL2L1(2), BIRC3(1), CASP3(1), CASP6(1), CASP8(4), CASP9(3), DFFA(4) 2601865 18 17 18 6 8 0 5 1 4 0 0.765 1.000 1.000 224 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(2), BFAR(2), BRAF(1), CREB5(5), RAF1(1), SNX13(4), SRC(4), TERF2IP(2) 2151152 21 17 21 6 10 1 3 3 4 0 0.593 1.000 1.000 225 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(1), CCNH(3), CDC25A(1), CDK7(3), MNAT1(1), XPO1(3) 1670908 12 9 12 5 7 1 1 1 2 0 0.858 1.000 1.000 226 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 FUCA2(2), GLB1(2), HEXA(1), HEXB(2), LCT(4), MAN2C1(1), MANBA(2), NEU2(2), NEU4(1) 3185924 17 16 17 4 11 1 3 1 1 0 0.376 1.000 1.000 227 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(1), IFNAR2(1), JAK1(3), STAT1(4), STAT2(2), TYK2(2) 2088938 13 11 13 9 5 0 2 2 4 0 0.957 1.000 1.000 228 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(2), CYP51A1(2), DHCR24(2), FDPS(1), GGCX(2), HMGCR(1), IDI2(3), LSS(3), NSDHL(1), PMVK(1), SC4MOL(4), SC5DL(1), TM7SF2(1), VKORC1(1) 3729681 25 19 25 6 14 2 4 5 0 0 0.267 1.000 1.000 229 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(1), CASP8(4), FADD(1), MAP2K1(1), MAP2K4(1), MAP3K1(3), MAPK3(3), MAPK8(4), NFKB1(1), NSMAF(4), RAF1(1), RELA(2), RIPK1(2), SMPD1(3), TRADD(1), TRAF2(2) 3971477 34 29 34 8 15 1 6 6 6 0 0.319 1.000 1.000 230 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 B4GALT1(1), DPM1(1), FUT8(5), MAN1A1(3), MAN1B1(5), MGAT1(4), MGAT2(1), MGAT3(1), MGAT4A(2), ST6GAL1(1) 3840331 24 17 24 5 13 0 4 7 0 0 0.224 1.000 1.000 231 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(1), BIRC3(1), CASP3(1), CASP8(4), CASP9(3), DFFA(4), PRF1(4), SCAP(3), SREBF1(4), SREBF2(2) 3530946 27 25 27 7 11 0 10 3 3 0 0.416 1.000 1.000 232 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 FOS(3), HRAS(6), MAP2K1(1), MAPK3(3), MYC(1), NFKB1(1), NFKBIA(2), PLCB1(4), PRKCA(1), RAF1(1), RELA(2) 3006215 25 22 24 7 9 1 7 6 2 0 0.474 1.000 1.000 233 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 EIF2B5(2), EIF2S3(2), EIF4E(1), EIF4EBP1(1), IGF1R(5), INPPL1(2), PDK2(1), PDPK1(1), PIK3CA(26), PIK3R1(2), PPP2CA(1), PTEN(5), RPS6(3) 3810509 52 40 37 11 32 2 9 4 5 0 0.206 1.000 1.000 234 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 CDKN1B(5), ITGB1(1), MAPK3(3), PDK2(1), PDPK1(1), PIK3CA(26), PIK3R1(2), PTEN(5), PTK2(3), SOS1(5) 3734241 52 40 37 10 38 2 3 3 6 0 0.244 1.000 1.000 235 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(8), ARHGEF1(6), GNA13(5), GNB1(5), MYL2(2), MYLK(5), PLCB1(4), PPP1R12B(2), PRKCA(1), ROCK1(4) 3997666 42 27 41 9 24 2 3 8 5 0 0.307 1.000 1.000 236 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACSL1(1), CPT1A(2), EHHADH(1), HADHA(3), SCP2(2) 3254546 9 9 9 1 9 0 0 0 0 0 0.234 1.000 1.000 237 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 UBE2A(1), UBE2B(1), UBE2C(1), UBE2D3(1), UBE2I(1), UBE2J1(4), UBE2L6(1), UBE2N(2), UBE2S(1), UBE3A(5) 2030812 18 14 18 8 9 3 3 1 2 0 0.903 1.000 1.000 238 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(1), PSMA5(1), PSMA6(1), PSMB1(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB8(2), PSMB9(1) 1690643 11 11 11 5 7 0 2 1 1 0 0.857 1.000 1.000 239 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(3), EIF4E(1), FBL(1), MAPK14(1), NCL(1) 1735727 7 7 7 7 5 0 1 0 1 0 0.989 1.000 1.000 240 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(6), MAP3K14(2), MAPK14(1), MAPK8(4), NFKB1(1), RELA(2), TNFRSF13C(1), TNFSF13B(3), TRAF2(2), TRAF6(1) 2807196 23 18 23 8 13 0 3 2 5 0 0.722 1.000 1.000 241 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(1), ACO2(2), FH(3), IDH1(3), MDH1(1) 1720729 10 10 10 5 5 0 2 2 1 0 0.861 1.000 1.000 242 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), ALDH3A1(2), ALDH9A1(2) 2556311 12 12 12 4 7 0 2 1 2 0 0.559 1.000 1.000 243 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(1), CALM2(1), DLG4(3), GRIN1(6), GRIN2A(9), GRIN2B(3), GRIN2C(5), GRIN2D(2), NOS1(4), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(1), SYT1(2) 4942895 54 37 54 12 23 5 12 9 5 0 0.129 1.000 1.000 244 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(3), CALM1(1), CALM2(1), FOS(3), GNAI1(1), GNAS(4), GNB1(5), HRAS(6), MAP2K1(1), MAPK3(3), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(1), RAF1(1), RPS6KA3(2), SYT1(2) 6756300 67 44 66 11 31 6 13 9 8 0 0.0371 1.000 1.000 245 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(3), ANKRD1(1), DUSP14(2), EIF4E(1), EIF4EBP1(1), IFNG(1), IFRD1(2), IL1A(1), JUND(1), MYOG(1), NR4A3(1), WDR1(2) 2067085 17 15 17 6 9 3 3 0 2 0 0.716 1.000 1.000 246 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 CDK5(1), CDK5R1(1), CHN1(3), LIMK1(2), MAP3K1(3), MYL2(2), MYLK(5), NCF2(4), PDGFRA(7), PIK3CA(26), PIK3R1(2), PLD1(3), PPP1R12B(2), RAC1(1), RALBP1(1), TRIO(13), VAV1(2) 6754403 78 60 63 13 46 3 14 7 8 0 0.0309 1.000 1.000 247 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(1), JAK1(3), PTPRU(4), REG1A(3), STAT1(4), STAT2(2), TYK2(2) 2418601 19 15 19 9 8 0 5 2 4 0 0.771 1.000 1.000 248 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(1), FOS(3), HRAS(6), IL3RA(3), JAK2(2), MAP2K1(1), MAPK3(3), RAF1(1), SOS1(5), STAT5B(2) 3418311 27 24 26 7 15 1 5 3 3 0 0.366 1.000 1.000 249 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), BCAT2(1), IARS2(2), ILVBL(1), LARS(1), LARS2(1), PDHA2(2), VARS(3), VARS2(4) 3595155 16 16 16 4 10 1 5 0 0 0 0.457 1.000 1.000 250 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 CHUK(6), IFNG(1), IKBKB(4), MAP3K1(3), MAP3K5(4), MAP4K5(1), MAPK14(1), MAPK8(4), NFKB1(1), NFKBIA(2), RELA(2), TNFRSF9(2), TRAF2(2) 3720840 33 27 33 9 15 0 9 2 7 0 0.550 1.000 1.000 251 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA5(1), PSMA6(1), PSMB1(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMC2(8), PSMC3(2), PSMD1(4), PSMD11(3), PSMD12(2), PSMD6(1) 3091312 28 23 28 9 21 0 2 1 4 0 0.671 1.000 1.000 252 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(1), CALM2(1), CCR5(2), CXCR4(2), FOS(3), MAPK14(1), MAPK8(4), PLCG1(3), PRKCA(1), PTK2B(3), SYT1(2) 2661183 23 21 23 9 10 0 4 5 4 0 0.784 1.000 1.000 253 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(1), DHRS1(1), DHRS7(2), DHRSX(3), HSD3B7(1), PON1(1), PON2(1), RDH13(1) 1745635 11 10 11 7 6 0 4 0 1 0 0.888 1.000 1.000 254 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX15(2), ALOX5(2), DPEP1(2), GGT1(1), LTA4H(1), PLA2G2A(1), PLA2G6(1), PTGIS(1), PTGS2(2), TBXAS1(3) 2910685 16 13 16 9 7 0 3 2 4 0 0.877 1.000 1.000 255 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(3), ACTR3(1), ARPC2(3), ARPC4(1), NCK1(1), NCKAP1(5), NTRK1(4), PIR(1), RAC1(1), WASF2(3), WASF3(1), WASL(1) 2952250 25 20 25 6 16 1 5 2 1 0 0.459 1.000 1.000 256 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(7), CSF1(2), IL1B(1), IL6R(1), SPN(1), TNFRSF1B(3), TNFRSF8(4), TNFSF8(3) 2560010 22 17 21 6 12 0 8 1 1 0 0.351 1.000 1.000 257 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(1), GLI2(4), GLI3(10), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), SMO(2) 3224307 24 19 24 9 8 1 11 0 4 0 0.721 1.000 1.000 258 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(6), IKBKAP(4), IKBKB(4), MAP3K1(3), MAP3K14(2), NFKB1(1), NFKBIA(2), RELA(2), TNFAIP3(2), TRAF6(1) 3505989 27 23 27 8 14 1 5 1 6 0 0.621 1.000 1.000 259 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(2), GALNS(1), GLB1(2), GNS(2), GUSB(1), HEXA(1), HEXB(2), IDS(1), LCT(4), NAGLU(1) 2785263 17 17 17 5 10 1 2 3 1 0 0.470 1.000 1.000 260 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABP1(3), ALDH3A1(2), ALDH9A1(2), AOC3(1), CNDP1(1), DPYD(5), DPYS(5), EHHADH(1), GAD1(5), HADHA(3), SRM(2), UPB1(3) 5220751 33 27 33 7 15 1 9 5 3 0 0.190 1.000 1.000 261 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(3), ACY3(3), ALDH3A1(2), ALDH3B1(2), ALDH9A1(2), AOC3(1), ASPA(2), CARM1(2), CNDP1(1), DDC(3), HAL(3), HDC(2), HNMT(1), LCMT2(1), MAOA(1), METTL2B(1), PRMT5(3), PRMT6(1), PRMT7(5), PRMT8(4), UROC1(1), WBSCR22(3) 7659402 47 42 46 9 22 2 12 7 4 0 0.0621 1.000 1.000 262 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(3), CAMK2B(2), CAMK2D(1), CAMK2G(3), GNAS(4), HRAS(6), MAPK14(1), MAPK3(3), PIK3CA(26), PIK3R1(2), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(1), RAC1(1), RPS6KA1(1), RPS6KA5(3), SOS1(5) 5636847 69 48 53 14 44 3 12 5 5 0 0.0946 1.000 1.000 263 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2), EHHADH(1), HADHA(3), SDS(1) 2349921 12 11 12 6 8 0 1 1 2 0 0.794 1.000 1.000 264 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(4), GLB1(2), HEXA(1), HEXB(2), LCT(4), SLC33A1(3), ST3GAL1(1), ST3GAL5(2), ST6GALNAC3(2), ST6GALNAC4(1), ST6GALNAC5(3), ST6GALNAC6(1), ST8SIA1(1) 3182798 27 25 27 9 15 1 4 5 2 0 0.483 1.000 1.000 265 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(1), ACO2(2), GRHPR(1), HAO1(1), HAO2(1), HYI(2), MDH1(1), MTHFD1(2), MTHFD1L(2), MTHFD2(2) 2474259 15 14 15 7 5 0 7 1 2 0 0.874 1.000 1.000 266 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CTH(2), GGT1(1), MAT1A(2), SCLY(1) 2392384 6 6 6 8 2 1 1 0 2 0 0.996 1.000 1.000 267 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(7), ACE2(2), AGT(1), AGTR2(1), ANPEP(3), CPA3(3), CTSG(3), ENPEP(3), LNPEP(1), MME(4), REN(2), THOP1(3) 4093353 33 27 32 9 19 0 6 3 5 0 0.326 1.000 1.000 268 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(6), CREBBP(18), EP300(26), IKBKB(4), IL1B(1), IL8(1), MAP2K3(2), MAP3K14(2), MAP3K7(3), MAPK11(2), MAPK14(1), MYD88(1), NFKB1(1), NFKBIA(2), NR3C1(1), RELA(2), TGFBR2(3), TLR2(2) 5729563 78 52 77 17 30 3 16 5 24 0 0.254 1.000 1.000 269 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(2), ACTN2(3), ACTN3(2), CSK(4), CTNNA1(1), CTNNA2(2), CTNNB1(4), PTK2(3), SRC(4), VCL(1) 3716291 26 23 26 6 17 2 5 1 1 0 0.293 1.000 1.000 270 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(1), DCXR(1), GUSB(1), UGDH(2), UGP2(5), UGT1A1(3), UGT1A3(3), UGT1A5(1), UGT1A6(1), UGT1A9(2), UGT2A1(1), UGT2A3(3), UGT2B10(2), UGT2B28(2), UGT2B4(2), UGT2B7(1), XYLB(5) 5221356 36 26 34 8 20 3 5 5 3 0 0.251 1.000 1.000 271 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(1), ACO2(2), AFMID(2), GRHPR(1), HAO1(1), HAO2(1), HYI(2), MDH1(1), MTHFD1(2), MTHFD1L(2), MTHFD2(2) 2592482 17 16 17 7 6 1 7 1 2 0 0.802 1.000 1.000 272 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(1), JAK1(3), JAK2(2), TYK2(2) 2026709 9 9 9 8 5 0 2 1 1 0 0.988 1.000 1.000 273 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(1), JAK1(3), JAK2(2), TYK2(2) 2026709 9 9 9 8 5 0 2 1 1 0 0.988 1.000 1.000 274 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(1), POLR2B(1), POLR2C(2), POLR2D(1), POLR2E(1), POLR2F(1), POLRMT(2) 2597919 9 8 9 3 6 0 1 2 0 0 0.668 1.000 1.000 275 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(13), CPT1A(2), LEPR(4), PRKAA2(4), PRKAB2(1), PRKAG1(2) 2805492 26 22 26 9 15 1 5 2 3 0 0.761 1.000 1.000 276 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(3), ADRB2(2), GNAS(4), PLCE1(2), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1) 2857621 18 15 18 8 7 1 6 1 3 0 0.870 1.000 1.000 277 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 EHHADH(1), HADH(1), HADHA(3), HSD17B10(1), HSD17B4(3), SIRT1(1), SIRT5(1), VNN2(2) 2293187 13 12 13 5 10 1 0 1 1 0 0.787 1.000 1.000 278 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(3), EIF2AK4(2), EIF2B5(2), EIF2S3(2), PPP1CA(4) 2232566 13 11 13 6 6 0 3 3 1 0 0.906 1.000 1.000 279 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(6), EGF(4), EGFR(3), HGS(2), RAB5A(1), TFRC(2) 2484220 18 17 18 5 11 0 4 2 1 0 0.617 1.000 1.000 280 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CLOCK(1), CRY1(1), CRY2(3), CSNK1E(1), NPAS2(1), NR1D1(3), PER1(3), PER2(1), PER3(3) 3289910 17 15 17 7 6 0 7 1 3 0 0.867 1.000 1.000 281 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(1), B3GNT2(2), B3GNT7(1), B4GALT1(1), CHST2(1), CHST4(2), CHST6(1), FUT8(5), ST3GAL1(1) 2409373 15 15 14 9 8 0 2 4 1 0 0.919 1.000 1.000 282 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(1), CSF1(2), HLA-DRA(1), HLA-DRB1(1), IFNG(1), IL12B(2), IL1A(1), IL6(2), IL7(1), IL8(1), TGFB3(1) 2576046 14 14 14 5 8 0 5 0 1 0 0.513 1.000 1.000 283 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD86(1), HLA-DRA(1), HLA-DRB1(1), IFNG(1), IFNGR2(2), IL12B(2), IL12RB1(2), IL12RB2(1), IL18R1(1), IL2RA(1), IL4R(1) 2447735 14 14 14 5 4 1 8 0 1 0 0.703 1.000 1.000 284 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(1), AMT(1), ATIC(1), GART(1), MTHFD1(2), MTHFD1L(2), MTHFD2(2), MTHFR(1), MTHFS(1), MTR(3), SHMT1(1), TYMS(1) 3458365 17 14 17 8 7 1 4 2 3 0 0.880 1.000 1.000 285 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA5(1), PSMA6(1), PSMB1(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMC3(2), UBE2A(1), UBE3A(5) 2488114 16 15 16 6 11 0 2 2 1 0 0.763 1.000 1.000 286 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(1), ARSB(2), ARSD(2), ASAH1(2), GAL3ST1(2), GALC(3), GBA(2), GLA(1), GLB1(2), LCT(4), NEU2(2), NEU4(1), PPAP2A(5), PPAP2B(1), PPAP2C(1), SMPD1(3), SMPD2(2), SPTLC1(3), SPTLC2(3), UGCG(1) 4658004 43 34 43 11 24 1 8 4 6 0 0.270 1.000 1.000 287 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 IL2RG(3), IL4R(1), IRS1(3), JAK1(3), JAK3(3), STAT6(3) 2864720 16 13 16 8 9 0 2 3 2 0 0.879 1.000 1.000 288 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 FUCA2(2), GLB1(2), HEXA(1), HEXB(2), LCT(4), MAN2B1(1), MAN2B2(1), MAN2C1(1), MANBA(2), NEU2(2), NEU4(1) 3931006 19 18 19 5 12 1 4 1 1 0 0.390 1.000 1.000 289 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(3), CALM1(1), CALM2(1), FCER1A(2), FOS(3), HRAS(6), LYN(2), MAP2K1(1), MAP2K4(1), MAP2K7(2), MAP3K1(3), MAPK3(3), MAPK8(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), PAK2(1), PIK3CA(26), PIK3R1(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), RAF1(1), SOS1(5), SYK(1), SYT1(2), VAV1(2) 8314441 98 66 82 17 56 6 15 14 7 0 0.0308 1.000 1.000 290 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(2), GTF2A1(1), GTF2E1(1), GTF2F1(1), NCOA1(10), NCOA2(4), NCOA3(5), NCOR2(10), RARA(3), RXRA(12) 4825218 49 41 43 10 24 2 13 3 7 0 0.188 1.000 1.000 291 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1R(1), C1S(2), C2(1), C3(5), C5(3), C8A(2), C9(5) 3370749 19 17 19 6 7 1 8 1 2 0 0.619 1.000 1.000 292 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(1), F2R(2), F5(9), FGA(7), FGB(1), FGG(3), PROS1(4), SERPINC1(1) 3165429 28 24 28 8 19 1 7 0 1 0 0.551 1.000 1.000 293 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(3), LCT(4), MPI(2), PGM1(2), PYGL(1), PYGM(4), TREH(1) 2587327 17 15 17 8 11 0 3 2 1 0 0.745 1.000 1.000 294 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(1), AMT(1), ATIC(1), GART(1), MTFMT(1), MTHFD1(2), MTHFD1L(2), MTHFD2(2), MTHFR(1), MTHFS(1), MTR(3), SHMT1(1), TYMS(1) 3662369 18 15 18 9 8 1 4 2 3 0 0.912 1.000 1.000 295 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(2), GALNS(1), GLB1(2), GNS(2), GUSB(1), HEXA(1), HEXB(2), HGSNAT(1), HPSE(3), HPSE2(1), HYAL2(2), IDS(1), LCT(4), NAGLU(1), SPAM1(1) 3957115 25 23 25 8 15 1 3 4 2 0 0.481 1.000 1.000 296 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 DLD(2), DUSP10(3), DUSP4(1), DUSP8(3), GAB1(2), GADD45A(1), MAP2K4(1), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K12(1), MAP3K13(6), MAP3K2(2), MAP3K4(5), MAP3K5(4), MAP3K7(3), MAP3K9(1), MAPK10(1), MAPK7(2), MAPK8(4), MAPK9(5), MYEF2(2), NFATC3(2), NR2C2(2), PAPPA(4), TP53(75), TRAF6(1), ZAK(1) 9719875 140 83 115 27 47 1 53 10 29 0 0.0522 1.000 1.000 297 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(1), GALNT2(2), GALNT3(1), GALNT4(1), GALNT6(1), GALNT7(1), GALNT8(2), GALNT9(1), GCNT1(1), ST3GAL1(1), WBSCR17(3) 2788109 15 14 15 7 10 1 2 1 1 0 0.832 1.000 1.000 298 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1R(1), C1S(2), C2(1), C3(5), C5(3), C8A(2), C8B(2), C9(5), MASP1(3) 4009297 24 21 24 7 10 1 9 2 2 0 0.521 1.000 1.000 299 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(1), DHRS7(2), DHRSX(3), ESCO1(1), ESCO2(1), MYST3(5), MYST4(3), PNPLA3(2) 3195593 18 16 18 5 8 0 6 2 2 0 0.611 1.000 1.000 300 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1R(1), C1S(2), C2(1), C3(5), C5(3), C8A(2), C9(5), MASP1(3), MASP2(3) 4109416 25 21 25 8 9 1 9 3 3 0 0.616 1.000 1.000 301 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(1), BLVRA(1), CP(1), EPRS(5), FECH(1), GUSB(1), HCCS(1), HMOX2(1), PPOX(4), UGT1A1(3), UGT1A3(3), UGT1A5(1), UGT1A6(1), UGT1A9(2), UGT2B4(2), UROD(1), UROS(2) 5282309 31 23 31 9 14 2 7 2 6 0 0.531 1.000 1.000 302 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(1), EIF1(1), EIF2B1(1), EIF2B2(3), EIF2B4(2), EIF2B5(2), EIF2S3(2), ELAVL1(2), FLT1(1), FLT4(1), HIF1A(1), HRAS(6), KDR(9), NOS3(6), PIK3CA(26), PIK3R1(2), PLCG1(3), PRKCA(1), PTK2(3) 6579220 73 49 57 15 43 3 12 6 9 0 0.0798 1.000 1.000 303 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 ABP1(3), AOC3(1), DDHD1(2), ESCO1(1), ESCO2(1), LIPA(1), MYST3(5), MYST4(3), PLA1A(2), PNPLA3(2), PPME1(1), PRDX6(4) 4883353 26 22 25 6 14 0 6 4 2 0 0.393 1.000 1.000 304 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 65 APAF1(1), ATM(19), ATR(3), BAI1(1), BAX(1), CASP3(1), CASP8(4), CASP9(3), CCNB1(1), CCNB3(5), CCND1(1), CCND3(5), CCNE2(1), CDK2(1), CDK4(2), CDK6(1), CDKN1A(18), CDKN2A(8), CHEK1(1), CHEK2(5), DDB2(4), GADD45A(1), GTSE1(2), LRDD(6), PERP(1), PTEN(5), RCHY1(1), RFWD2(2), RRM2(2), SERPINB5(1), SERPINE1(2), SESN1(2), SESN3(2), SFN(1), STEAP3(1), TP53(75), TP53I3(2), TP73(2), TSC2(2), ZMAT3(1) 12590250 197 95 171 32 73 2 57 12 53 0 0.00572 1.000 1.000 305 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(1), ACOT11(4), DHRS1(1), DHRS7(2), DHRSX(3), EHHADH(1), ESCO1(1), ESCO2(1), FN3K(2), GCDH(2), HADHA(3), MYST3(5), MYST4(3), PNPLA3(2), YOD1(1) 5016957 32 28 32 8 20 0 7 2 3 0 0.433 1.000 1.000 306 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(1), ARG2(1), ASL(3), CKMT2(2), CPS1(4), GATM(1), GLUD1(2), ODC1(1), PYCR1(3) 3394201 18 13 18 7 12 0 3 1 2 0 0.700 1.000 1.000 307 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(2), BST1(1), C9orf95(1), CD38(1), ENPP1(2), NADK(2), NADSYN1(3), NNMT(1), NNT(1), NT5C1A(3), NT5C1B(3), NT5C2(2), NT5C3(2), NT5E(3), NUDT12(1), QPRT(2) 4160390 30 23 30 8 17 3 8 2 0 0 0.435 1.000 1.000 308 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(1), CALM2(1), CHUK(6), EGR2(1), EGR3(1), MAP3K1(3), MYC(1), NFATC1(4), NFATC2(6), NFKB1(1), NFKBIA(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), RELA(2), SYT1(2), VIPR2(4) 5399164 55 39 55 13 24 5 10 4 12 0 0.270 1.000 1.000 309 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(3), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH3B1(2), ALDH9A1(2), AOC3(1), ASPA(2), CNDP1(1), DDC(3), HAL(3), HDC(2), HNMT(1), MAOA(1) 4712282 26 24 26 8 11 0 8 3 4 0 0.466 1.000 1.000 310 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GHR(2), HRAS(6), INSR(4), IRS1(3), JAK2(2), MAP2K1(1), MAPK3(3), PIK3CA(26), PIK3R1(2), PLCG1(3), PRKCA(1), RAF1(1), RPS6KA1(1), SLC2A4(1), SOS1(5), STAT5B(2) 6398577 63 48 47 15 44 2 8 7 2 0 0.167 1.000 1.000 311 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), CA12(1), CA4(1), CPS1(4), CTH(2), GLS(1), GLS2(1), GLUD1(2), HAL(3) 3668549 16 10 16 8 8 1 5 0 2 0 0.899 1.000 1.000 312 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(1), DCXR(1), GUSB(1), UCHL1(1), UGDH(2), UGT1A1(3), UGT1A3(3), UGT1A5(1), UGT1A6(1), UGT1A9(2), UGT2B4(2) 3378842 18 14 18 7 9 2 4 2 1 0 0.712 1.000 1.000 313 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(5), POLR1B(1), POLR1C(1), POLR1D(2), POLR2B(1), POLR2C(2), POLR2D(1), POLR2E(1), POLR2F(1), POLR3A(5), POLR3B(3), POLR3H(1) 4534686 24 18 24 8 13 1 4 3 3 0 0.672 1.000 1.000 314 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM1(1), CALM2(1), CD3E(1), FOS(3), FYN(1), HRAS(6), LAT(1), LCK(1), MAP2K1(1), MAP2K4(1), MAP3K1(3), MAPK3(3), MAPK8(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), NFKB1(1), NFKBIA(2), PIK3CA(26), PIK3R1(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKCA(1), PTPN7(1), RAC1(1), RAF1(1), RASA1(4), RELA(2), SOS1(5), SYT1(2), VAV1(2), ZAP70(1) 9233999 104 69 88 20 61 6 17 11 9 0 0.0474 1.000 1.000 315 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG3(1), ATG5(1), ATG7(1), BECN1(2), GABARAP(1), IFNA16(1), IFNA4(3), IFNG(1), PIK3C3(5), PIK3R4(3), PRKAA2(4), ULK1(3), ULK2(5) 4047642 31 23 31 9 18 2 8 3 0 0 0.549 1.000 1.000 316 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 CTH(2), DNMT1(4), DNMT3A(1), DNMT3B(1), MAT1A(2), MTFMT(1), MTR(3), SRM(2) 4005994 16 14 16 5 8 2 3 1 2 0 0.542 1.000 1.000 317 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(4), ALDH3A1(2), ALDH9A1(2), CYP2C19(1), CYP2C9(2), DHRS1(1), DHRS7(2), DHRSX(3), EHHADH(1), ESCO1(1), ESCO2(1), HADHA(3), MYST3(5), MYST4(3), PNPLA3(2), YOD1(1) 5968722 34 29 34 8 20 0 8 2 4 0 0.277 1.000 1.000 318 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(2), FBP1(1), MDH1(1), ME1(2), ME3(1), PKLR(1), PKM2(2), RPIA(2), TKTL1(3), TKTL2(1) 3902271 16 13 16 8 10 0 3 1 2 0 0.785 1.000 1.000 319 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(2), FBP1(1), MDH1(1), ME1(2), ME2(1), ME3(1), PKLR(1), PKM2(2), RPIA(2) 3489668 13 10 13 5 8 0 3 1 1 0 0.644 1.000 1.000 320 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(1), ACAD9(1), ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), DHRS1(1), DHRS7(2), DHRSX(3), ESCO1(1), ESCO2(1), MYST3(5), MYST4(3), PNPLA3(2) 4817399 28 24 28 7 15 0 8 3 2 0 0.423 1.000 1.000 321 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(3), CALM1(1), CALM2(1), CAPNS2(1), EP300(26), HDAC1(1), HDAC2(1), MEF2D(1), NFATC1(4), NFATC2(6), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKCA(1), SYT1(2) 4717869 58 40 58 14 20 5 9 9 15 0 0.434 1.000 1.000 322 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(2), FBP1(1), GPI(3), H6PD(5), PFKP(1), PGD(1), PGM1(2), RBKS(1), RPIA(2) 3959552 18 17 18 8 7 0 8 1 2 0 0.704 1.000 1.000 323 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(2), AKT3(1), BTK(3), CDKN2A(8), GSK3A(1), INPP5D(2), PIK3CA(26), PPP1R13B(3), PTEN(5), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), SFN(1), SOS1(5), SOS2(4), TEC(4), YWHAB(2), YWHAE(2), YWHAQ(1), YWHAZ(3) 6943543 79 45 64 16 55 3 8 4 9 0 0.166 1.000 1.000 324 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(4), ACTB(5), ACTG1(4), ARHGEF2(2), ARPC5(1), CDH1(6), CLDN1(1), CTNNB1(4), CTTN(2), EZR(6), FYN(1), HCLS1(1), ITGB1(1), KRT18(3), LY96(1), NCK1(1), NCL(1), OCLN(3), PRKCA(1), RHOA(5), ROCK1(4), ROCK2(6), TLR4(3), TLR5(5), TUBA1A(2), TUBA1C(1), TUBA3C(3), TUBA3D(2), TUBA3E(1), TUBA8(1), TUBAL3(1), TUBB(1), TUBB2C(1), TUBB3(5), TUBB4(2), TUBB6(2), TUBB8(2), WAS(1), WASL(1), YWHAQ(1), YWHAZ(3) 10142431 101 64 100 19 59 1 15 13 13 0 0.0410 1.000 1.000 325 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(4), ACTB(5), ACTG1(4), ARHGEF2(2), ARPC5(1), CDH1(6), CLDN1(1), CTNNB1(4), CTTN(2), EZR(6), FYN(1), HCLS1(1), ITGB1(1), KRT18(3), LY96(1), NCK1(1), NCL(1), OCLN(3), PRKCA(1), RHOA(5), ROCK1(4), ROCK2(6), TLR4(3), TLR5(5), TUBA1A(2), TUBA1C(1), TUBA3C(3), TUBA3D(2), TUBA3E(1), TUBA8(1), TUBAL3(1), TUBB(1), TUBB2C(1), TUBB3(5), TUBB4(2), TUBB6(2), TUBB8(2), WAS(1), WASL(1), YWHAQ(1), YWHAZ(3) 10142431 101 64 100 19 59 1 15 13 13 0 0.0410 1.000 1.000 326 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(4), CSK(4), DAG1(1), EPHB2(3), FBXW7(16), GRAP2(2), ITK(2), ITPKA(2), ITPKB(1), LAT(1), LCK(1), NCK1(1), NFAT5(7), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), NFKBIL2(2), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PAK7(2), PLCG1(3), PTPRC(5), RAF1(1), RASGRP1(1), RASGRP2(2), RASGRP3(2), SOS1(5), SOS2(4), VAV1(2), ZAP70(1) 10779706 95 60 91 17 47 3 18 9 18 0 0.0353 1.000 1.000 327 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(2), CSF1R(6), DDX20(2), E2F1(1), E2F4(1), ETS1(2), ETV3(1), FOS(3), HDAC2(1), HDAC5(2), HRAS(6), NCOR2(10), RBL1(1), RBL2(3), SIN3A(4) 5039557 45 37 44 11 17 1 14 6 7 0 0.285 1.000 1.000 328 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(3), ALDH3A1(2), ALDH3B1(2), AOC3(1), DDC(3), EPX(2), ESCO1(1), ESCO2(1), HPD(2), LPO(4), MAOA(1), MPO(2), MYST3(5), MYST4(3), PNPLA3(2), PRDX6(4), TPO(9) 6602111 47 37 46 10 23 0 15 5 4 0 0.136 1.000 1.000 329 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 ALOX15(2), ALOX5(2), CYP4F2(4), CYP4F3(2), EPX(2), GGT1(1), LPO(4), LTA4H(1), MPO(2), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), PRDX1(2), PRDX2(4), PRDX5(1), PRDX6(4), PTGES2(2), PTGIS(1), PTGS2(2), TBXAS1(3), TPO(9) 5401593 56 41 55 17 28 0 14 5 9 0 0.286 1.000 1.000 330 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 FOS(3), HRAS(6), JAK2(2), MAP2K1(1), MAP2K4(1), MAP3K1(3), MAPK3(3), MAPK8(4), MYC(1), PIK3CA(26), PIK3R1(2), RAF1(1), SOS1(5), STAT1(4), STAT5B(2) 5427924 64 50 48 15 41 4 9 7 3 0 0.253 1.000 1.000 331 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM1(1), CALM2(1), FPR1(1), GNA15(1), GNB1(5), HRAS(6), MAP2K1(1), MAP2K3(2), MAP3K1(3), MAPK14(1), MAPK3(3), NCF2(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), NFKB1(1), NFKBIA(2), PIK3C2G(3), PLCB1(4), PPP3CA(4), PPP3CB(4), PPP3CC(2), RAC1(1), RAF1(1), RELA(2), SYT1(2) 7374256 68 46 67 15 31 6 15 10 6 0 0.178 1.000 1.000 332 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(1), BTK(3), CALM1(1), CALM2(1), CD79A(1), CD79B(1), FOS(3), HRAS(6), LYN(2), MAP2K1(1), MAP3K1(3), MAPK14(1), MAPK3(3), MAPK8(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKCA(1), RAC1(1), RAF1(1), SOS1(5), SYK(1), SYT1(2), VAV1(2) 7389471 70 52 69 15 34 3 14 11 8 0 0.160 1.000 1.000 333 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(8), DIAPH1(2), FYN(1), HRAS(6), ITGA1(1), ITGB1(1), MAP2K1(1), MAPK3(3), MYL2(2), MYLK(5), PFN1(2), PIK3CA(26), PIK3R1(2), PTK2(3), RAF1(1), ROCK1(4), SRC(4), TLN1(2) 7215814 74 51 58 15 49 2 11 8 4 0 0.126 1.000 1.000 334 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(3), ACY1(1), ADC(1), ALDH3A1(2), ALDH9A1(2), AOC3(1), ARG2(1), ASL(3), ASS1(2), CPS1(4), GATM(1), MAOA(1), ODC1(1), SAT2(1), SRM(2) 5688955 26 21 26 8 14 1 6 2 3 0 0.409 1.000 1.000 335 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT3(1), ANKRD6(3), APC(7), AXIN1(3), AXIN2(4), CER1(2), CSNK1A1(3), CTNNB1(4), DACT1(2), DKK1(1), DKK2(3), DKK3(3), DKK4(1), FSTL1(1), GSK3A(1), LRP1(12), MVP(4), PSEN1(5), PTPRA(1), WIF1(2) 7815319 63 47 62 13 28 3 15 5 12 0 0.157 1.000 1.000 336 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(3), DOCK1(4), FOS(3), GAB1(2), HGF(1), HRAS(6), ITGA1(1), ITGB1(1), MAP2K1(1), MAP4K1(3), MAPK3(3), MAPK8(4), MET(5), PIK3CA(26), PIK3R1(2), PTEN(5), PTK2(3), PTK2B(3), RAF1(1), RAP1A(1), RAP1B(2), RASA1(4), SOS1(5), SRC(4) 8508857 93 61 77 19 59 4 16 8 6 0 0.0994 1.000 1.000 337 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(1), ACAA2(1), ACADSB(1), ACAT1(1), ACOX1(1), ACOX3(3), ACSL1(1), ACSL5(1), ACSL6(2), ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), ALDH3A1(2), ALDH9A1(2), CPT1A(2), CPT1B(2), CPT1C(2), CYP4A11(2), CYP4A22(4), EHHADH(1), GCDH(2), HADH(1), HADHA(3), HADHB(2), HSD17B10(1), HSD17B4(3), PECI(3) 9463608 52 40 52 12 36 1 6 4 5 0 0.124 1.000 1.000 338 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(3), GNAS(4), GNB1(5), HRAS(6), IGF1R(5), ITGB1(1), KLK2(1), MAP2K1(1), MAPK3(3), MKNK1(1), MYC(1), NGFR(3), PDGFRA(7), PPP2CA(1), PTPRR(1), RAF1(1), RPS6KA1(1), RPS6KA5(3), SOS1(5), SRC(4) 6414231 57 40 56 14 28 3 17 8 1 0 0.239 1.000 1.000 339 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 MAP2K4(1), MAP2K7(2), MAPK10(1), MAPK11(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK8(4), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(3), MAPK9(5), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), NFKBIL2(2), PIK3CA(26), PIK3CD(3), PIK3R1(2), SYT1(2), TRAF2(2), TRAF6(1) 6506849 79 55 64 21 47 4 13 8 7 0 0.249 1.000 1.000 340 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT3(1), BTK(3), CD19(2), CDKN2A(8), GAB1(2), ITPR1(7), ITPR2(9), ITPR3(4), LYN(2), PHF11(1), PIK3CA(26), PLCG2(3), PPP1R13B(3), PREX1(3), PTEN(5), PTPRC(5), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), SYK(1), TEC(4), VAV1(2) 10646368 97 59 82 22 60 5 12 7 13 0 0.0736 1.000 1.000 341 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(1), ARSD(2), ASAH1(2), B4GALT6(2), GAL3ST1(2), GALC(3), GBA(2), GLA(1), GLB1(2), LCT(4), NEU2(2), NEU4(1), PPAP2A(5), PPAP2B(1), PPAP2C(1), SGMS2(1), SMPD1(3), SMPD2(2), SMPD3(1), SMPD4(3), SPHK2(4), SPTLC1(3), SPTLC2(3), UGCG(1), UGT8(2) 6902767 54 39 54 16 26 1 13 5 9 0 0.325 1.000 1.000 342 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(1), ACVR1C(1), AKT3(1), ARRB1(1), BDNF(1), BRAF(1), CACNA1A(6), CACNA1B(2), CACNA1C(5), CACNA1D(5), CACNA1E(4), CACNA1F(4), CACNA1G(6), CACNA1H(1), CACNA1I(4), CACNA1S(5), CACNA2D1(5), CACNA2D2(3), CACNA2D3(1), CACNA2D4(1), CACNB1(2), CACNB2(2), CACNB4(1), CACNG2(1), CACNG3(1), CACNG4(1), CACNG5(1), CACNG6(2), CACNG7(1), CACNG8(1), CASP3(1), CHUK(6), DAXX(1), DUSP10(3), DUSP14(2), DUSP16(4), DUSP2(1), DUSP4(1), DUSP6(3), DUSP7(3), DUSP8(3), ECSIT(1), EGF(4), EGFR(3), ELK4(1), FGF1(1), FGF10(1), FGF12(1), FGF13(3), FGF14(1), FGF17(1), FGF3(2), FGF6(1), FGF8(2), FGFR1(3), FGFR2(4), FGFR3(21), FGFR4(3), FLNA(5), FLNB(6), FLNC(5), FOS(3), GADD45A(1), HRAS(6), IKBKB(4), IL1A(1), IL1B(1), JUND(1), MAP2K1(1), MAP2K3(2), MAP2K4(1), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K12(1), MAP3K13(6), MAP3K14(2), MAP3K2(2), MAP3K4(5), MAP3K5(4), MAP3K6(3), MAP3K7(3), MAP3K8(2), MAP4K1(3), MAP4K2(4), MAP4K3(4), MAP4K4(2), MAPK10(1), MAPK11(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK7(2), MAPK8(4), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(3), MAPK9(5), MAPKAPK2(1), MAPT(5), MEF2C(2), MKNK1(1), MOS(2), MYC(1), NF1(13), NFATC2(6), NFATC4(1), NFKB1(1), NFKB2(1), NLK(2), NR4A1(1), NRAS(2), NTF3(1), NTRK1(4), NTRK2(4), PAK2(1), PDGFB(1), PDGFRA(7), PDGFRB(4), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), PPM1A(3), PPM1B(2), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(2), PPP5C(1), PRKACB(1), PRKCA(1), PRKCG(2), PRKX(1), PTPN7(1), PTPRR(1), RAC1(1), RAF1(1), RAP1A(1), RAP1B(2), RAPGEF2(6), RASA1(4), RASA2(1), RASGRF1(2), RASGRF2(2), RASGRP1(1), RASGRP2(2), RASGRP3(2), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), RPS6KA4(1), RPS6KA5(3), RPS6KA6(2), RRAS(1), SOS1(5), SOS2(4), STK3(2), STK4(3), TAOK1(2), TAOK2(5), TAOK3(2), TGFB3(1), TGFBR2(3), TP53(75), TRAF2(2), TRAF6(1), ZAK(1) 55196447 502 122 466 152 207 18 148 54 75 0 0.244 1.000 1.000 343 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(5), ACTG1(4), ACTN1(2), ACTN2(3), ACTN3(2), ACTN4(4), AKT3(1), ARHGAP5(8), BIRC3(1), BRAF(1), CAV2(1), CCND1(1), CCND3(5), COL11A1(10), COL11A2(3), COL1A1(2), COL1A2(4), COL2A1(4), COL4A1(3), COL4A2(5), COL4A4(4), COL4A6(1), COL5A1(8), COL5A2(5), COL5A3(3), COL6A2(1), COL6A3(10), COL6A6(10), COMP(5), CTNNB1(4), DIAPH1(2), DOCK1(4), EGF(4), EGFR(3), ERBB2(11), FARP2(2), FIGF(1), FLNA(5), FLNB(6), FLNC(5), FLT1(1), FN1(6), FYN(1), GRLF1(14), HGF(1), HRAS(6), IBSP(1), IGF1R(5), ITGA1(1), ITGA10(1), ITGA11(4), ITGA2(3), ITGA2B(7), ITGA3(4), ITGA4(6), ITGA5(3), ITGA6(2), ITGA7(2), ITGA8(5), ITGA9(3), ITGAV(3), ITGB1(1), ITGB3(2), ITGB4(5), ITGB5(2), ITGB8(1), KDR(9), LAMA1(6), LAMA2(14), LAMA3(17), LAMA4(5), LAMA5(8), LAMB1(5), LAMB2(4), LAMB3(3), LAMB4(3), LAMC1(5), LAMC2(2), LAMC3(4), MAP2K1(1), MAPK10(1), MAPK3(3), MAPK8(4), MAPK9(5), MET(5), MYL2(2), MYLK(5), MYLK2(4), MYLPF(1), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PAK7(2), PARVB(2), PDGFB(1), PDGFRA(7), PDGFRB(4), PDPK1(1), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIP5K1C(2), PPP1CA(4), PPP1CB(3), PPP1R12A(4), PRKCA(1), PRKCG(2), PTEN(5), PTK2(3), RAC1(1), RAF1(1), RAP1A(1), RAP1B(2), RELN(13), RHOA(5), ROCK1(4), ROCK2(6), SHC2(1), SHC4(4), SOS1(5), SOS2(4), SPP1(1), SRC(4), THBS2(6), THBS3(2), THBS4(2), TLN1(2), TLN2(5), TNC(5), TNN(2), TNR(7), TNXB(11), VAV1(2), VAV2(1), VAV3(2), VCL(1), VEGFB(2), VEGFC(1), VTN(2), VWF(7), ZYX(1) 71727353 570 120 550 199 293 18 126 69 64 0 0.965 1.000 1.000 344 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(2), ACTN1(2), ACTN2(3), ACTN3(2), ACTN4(4), APC(7), APC2(3), ARAF(1), ARHGEF1(6), ARHGEF12(4), ARHGEF4(2), ARHGEF6(2), ARHGEF7(3), ARPC2(3), ARPC4(1), ARPC5(1), BDKRB1(1), BRAF(1), CFL2(1), CHRM1(1), CHRM3(4), CHRM4(1), CSK(4), CYFIP1(4), CYFIP2(1), DIAPH1(2), DIAPH2(4), DIAPH3(4), DOCK1(4), EGF(4), EGFR(3), EZR(6), F2R(2), FGD1(4), FGF1(1), FGF10(1), FGF12(1), FGF13(3), FGF14(1), FGF17(1), FGF3(2), FGF6(1), FGF8(2), FGFR1(3), FGFR2(4), FGFR3(21), FGFR4(3), FN1(6), GIT1(2), GNA13(5), GRLF1(14), HRAS(6), IQGAP1(3), IQGAP2(1), IQGAP3(5), ITGA1(1), ITGA10(1), ITGA11(4), ITGA2(3), ITGA2B(7), ITGA3(4), ITGA4(6), ITGA5(3), ITGA6(2), ITGA7(2), ITGA8(5), ITGA9(3), ITGAD(2), ITGAE(3), ITGAL(2), ITGAM(3), ITGAV(3), ITGB1(1), ITGB2(3), ITGB3(2), ITGB4(5), ITGB5(2), ITGB8(1), LIMK1(2), MAP2K1(1), MAPK3(3), MOS(2), MYH10(7), MYH14(1), MYH9(13), MYL2(2), MYLK(5), MYLK2(4), MYLPF(1), NCKAP1(5), NCKAP1L(4), NRAS(2), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PAK7(2), PDGFB(1), PDGFRA(7), PDGFRB(4), PFN1(2), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIP4K2A(2), PIP4K2B(1), PIP4K2C(3), PIP5K1A(5), PIP5K1C(2), PPP1CA(4), PPP1CB(3), PPP1R12A(4), PPP1R12B(2), PTK2(3), RAC1(1), RAF1(1), RDX(2), RHOA(5), ROCK1(4), ROCK2(6), RRAS(1), SCIN(1), SLC9A1(1), SOS1(5), SOS2(4), SSH1(2), SSH2(6), SSH3(4), TIAM1(7), TIAM2(6), VAV1(2), VAV2(1), VAV3(2), VCL(1), WAS(1), WASF2(3), WASL(1) 53396905 462 120 435 129 248 9 104 53 48 0 0.114 1.000 1.000 345 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ABL1(4), ANAPC1(5), ANAPC2(3), ANAPC4(3), ANAPC5(1), ANAPC7(2), ATM(19), ATR(3), BUB1(8), BUB1B(5), CCNA1(1), CCNB1(1), CCNB3(5), CCND1(1), CCND3(5), CCNE2(1), CCNH(3), CDC14B(2), CDC16(1), CDC25A(1), CDC27(3), CDC6(5), CDC7(1), CDK2(1), CDK4(2), CDK6(1), CDK7(3), CDKN1A(18), CDKN1B(5), CDKN2A(8), CDKN2B(2), CDKN2D(1), CHEK1(1), CHEK2(5), CREBBP(18), CUL1(8), DBF4(6), E2F1(1), E2F2(1), E2F3(2), EP300(26), ESPL1(5), FZR1(2), GADD45A(1), HDAC1(1), HDAC2(1), MAD1L1(2), MAD2L1(1), MCM2(1), MCM3(1), MCM4(4), MCM6(2), ORC1L(1), ORC3L(3), PCNA(1), PKMYT1(1), PLK1(1), PRKDC(10), PTTG1(1), RB1(19), RBL1(1), RBL2(3), SFN(1), SKP1(1), SKP2(1), SMAD2(2), SMAD3(5), SMAD4(2), SMC1A(3), SMC1B(2), TGFB3(1), TP53(75), WEE1(2), YWHAB(2), YWHAE(2), YWHAQ(1), YWHAZ(3) 26168753 357 110 327 67 142 9 76 33 97 0 0.00844 1.000 1.000 346 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(13), ASH2L(1), CARM1(2), CTCFL(2), DOT1L(9), EED(3), EHMT1(2), EHMT2(4), EZH1(2), EZH2(3), FBXO11(1), HCFC1(4), HSF4(2), KDM6A(32), MEN1(1), MLL(21), MLL2(40), MLL3(30), MLL4(13), MLL5(6), NSD1(7), OGT(2), PAXIP1(3), PPP1CA(4), PPP1CB(3), PRDM2(7), PRDM7(2), PRDM9(5), PRMT5(3), PRMT6(1), PRMT7(5), PRMT8(4), RBBP5(2), SETD1A(3), SETD2(9), SETD8(2), SETDB1(4), SETDB2(1), SMYD3(1), STK38(2), SUV420H1(9), SUZ12(4), WHSC1(7), WHSC1L1(2) 22988078 283 109 275 64 129 8 32 26 88 0 0.393 1.000 1.000 347 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(7), APC2(3), AXIN1(3), AXIN2(4), CAMK2B(2), CAMK2D(1), CAMK2G(3), CCND1(1), CCND3(5), CER1(2), CHD8(5), CREBBP(18), CSNK1A1(3), CSNK1A1L(1), CSNK1E(1), CSNK2A1(4), CSNK2B(2), CTBP1(1), CTBP2(1), CTNNB1(4), CTNNBIP1(1), CUL1(8), DAAM1(7), DAAM2(3), DKK1(1), DKK2(3), DKK4(1), DVL2(2), DVL3(1), EP300(26), FBXW11(1), FOSL1(1), FZD10(1), FZD3(3), FZD4(1), FZD6(4), FZD7(2), FZD8(1), FZD9(2), LEF1(2), LRP5(2), LRP6(1), MAP3K7(3), MAPK10(1), MAPK8(4), MAPK9(5), MYC(1), NFAT5(7), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), NLK(2), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PORCN(1), PPARD(1), PPP2CA(1), PPP2R1A(1), PPP2R1B(3), PPP2R2B(1), PPP2R2C(1), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(2), PRICKLE1(2), PRICKLE2(2), PRKACB(1), PRKCA(1), PRKCG(2), PRKX(1), PSEN1(5), RAC1(1), RHOA(5), ROCK1(4), ROCK2(6), RUVBL1(3), SFRP2(1), SFRP4(2), SKP1(1), SMAD2(2), SMAD3(5), SMAD4(2), TBL1X(1), TBL1XR1(2), TBL1Y(2), TP53(75), VANGL1(2), VANGL2(3), WIF1(2), WNT2(2), WNT3A(1), WNT5A(1), WNT6(1), WNT7A(2), WNT7B(1), WNT8A(1) 31235905 358 109 330 82 140 18 100 34 66 0 0.0150 1.000 1.000 348 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(3), ADCY2(10), ADCY3(2), ADCY4(2), ADCY7(1), ADCY8(5), ADCY9(3), ADRA1A(4), ADRA1B(1), ADRA1D(2), ADRB1(1), ADRB2(2), ATP2A1(6), ATP2A2(2), ATP2A3(2), ATP2B1(5), ATP2B2(5), ATP2B3(1), ATP2B4(5), AVPR1A(1), AVPR1B(1), BDKRB1(1), BST1(1), CACNA1A(6), CACNA1B(2), CACNA1C(5), CACNA1D(5), CACNA1E(4), CACNA1F(4), CACNA1G(6), CACNA1H(1), CACNA1I(4), CACNA1S(5), CALM1(1), CALM2(1), CALML3(1), CALML6(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), CAMK4(1), CCKBR(3), CD38(1), CHRM1(1), CHRM3(4), CYSLTR2(1), EDNRA(1), EDNRB(2), EGFR(3), ERBB2(11), ERBB3(14), ERBB4(3), F2R(2), GNA14(2), GNA15(1), GNAL(1), GNAS(4), GRIN1(6), GRIN2A(9), GRIN2C(5), GRIN2D(2), GRM1(7), GRM5(5), HRH1(4), HTR2B(2), HTR2C(1), HTR4(2), HTR6(1), HTR7(1), ITPKA(2), ITPKB(1), ITPR1(7), ITPR2(9), ITPR3(4), LHCGR(2), LTB4R2(2), MYLK(5), MYLK2(4), NOS1(4), NOS3(6), NTSR1(1), OXTR(1), P2RX1(2), P2RX2(1), P2RX3(2), P2RX7(1), PDE1A(2), PDE1C(4), PDGFRA(7), PDGFRB(4), PHKA1(5), PHKA2(1), PHKB(1), PHKG2(2), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PLCD1(1), PLCD3(1), PLCD4(2), PLCE1(2), PLCG1(3), PLCG2(3), PLCZ1(2), PLN(1), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(2), PRKACB(1), PRKCA(1), PRKCG(2), PRKX(1), PTAFR(1), PTGER3(1), PTGFR(2), PTK2B(3), RYR1(12), RYR2(21), RYR3(14), SLC25A4(1), SLC25A6(1), SLC8A1(2), SLC8A2(2), SLC8A3(2), SPHK2(4), TACR1(2), TACR3(1), TRHR(2), TRPC1(2), VDAC1(1), VDAC2(2) 51940047 420 108 414 177 191 15 133 48 33 0 0.916 1.000 1.000 349 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(4), ATM(19), BUB1(8), BUB1B(5), CCNA1(1), CCNB1(1), CCNB3(5), CCND3(5), CCNE2(1), CCNH(3), CDAN1(4), CDC14B(2), CDC25A(1), CDC6(5), CDC7(1), CDH1(6), CDK2(1), CDK4(2), CDKN1A(18), CDKN2A(8), CHEK1(1), CHEK2(5), DTX4(1), E2F1(1), E2F2(1), E2F3(2), E2F4(1), E2F5(1), E2F6(1), EP300(26), ESPL1(5), GADD45A(1), HDAC1(1), HDAC2(1), HDAC4(2), HDAC5(2), HDAC6(2), HDAC8(1), MAD1L1(2), MAD2L1(1), MCM2(1), MCM3(1), MCM4(4), MCM6(2), MPEG1(2), MPL(1), ORC1L(1), ORC3L(3), PCNA(1), PLK1(1), PRKDC(10), PTPRA(1), PTTG1(1), RB1(19), RBL1(1), SKP2(1), SMAD4(2), TBC1D8(3), TP53(75), WEE1(2) 21182472 290 107 262 63 109 7 61 30 83 0 0.0651 1.000 1.000 350 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(5), ACTG1(4), COL11A1(10), COL11A2(3), COL17A1(2), COL1A1(2), COL1A2(4), COL2A1(4), COL4A1(3), COL4A2(5), COL4A4(4), COL4A6(1), COL5A1(8), COL5A2(5), COL5A3(3), COL6A2(1), COL6A3(10), COL6A6(10), COMP(5), DSC1(4), DSC2(2), DSC3(2), DSG1(7), DSG2(5), DSG3(1), DSG4(1), FN1(6), GJA1(1), GJA10(2), GJA9(2), GJC1(1), GJD2(2), IBSP(1), INA(1), ITGA6(2), ITGB4(5), KRT12(2), KRT13(1), KRT14(1), KRT15(3), KRT16(1), KRT17(1), KRT18(3), KRT2(1), KRT20(1), KRT24(1), KRT25(1), KRT28(1), KRT3(1), KRT31(1), KRT32(1), KRT33A(1), KRT33B(1), KRT34(1), KRT35(1), KRT36(2), KRT37(1), KRT38(2), KRT39(2), KRT4(2), KRT40(1), KRT6A(2), KRT6B(3), KRT6C(3), KRT7(2), KRT71(2), KRT72(1), KRT73(1), KRT74(1), KRT75(2), KRT76(1), KRT78(1), KRT79(3), KRT8(1), KRT82(1), KRT83(2), KRT84(4), KRT85(1), KRT9(1), LAMA1(6), LAMA2(14), LAMA3(17), LAMA4(5), LAMA5(8), LAMB1(5), LAMB2(4), LAMB3(3), LAMB4(3), LAMC1(5), LAMC2(2), LAMC3(4), LMNA(1), LMNB1(2), LMNB2(1), NES(8), PRPH(2), RELN(13), SPP1(1), THBS2(6), THBS3(2), THBS4(2), TNC(5), TNN(2), TNR(7), TNXB(11), VIM(2), VTN(2), VWF(7) 48145810 350 106 347 146 184 16 79 39 32 0 0.999 1.000 1.000 351 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT3(1), BCL2L1(2), CBL(4), CBLB(6), CCND1(1), CCND3(5), CISH(1), CLCF1(2), CNTF(1), CNTFR(1), CREBBP(18), CSF2RA(1), CSF2RB(1), CSF3R(2), EP300(26), EPOR(1), GHR(2), IFNA16(1), IFNA4(3), IFNAR1(1), IFNAR2(1), IFNG(1), IFNGR2(2), IL10RA(4), IL10RB(3), IL12B(2), IL12RB1(2), IL12RB2(1), IL13RA1(1), IL19(2), IL20RA(1), IL21(1), IL21R(5), IL22RA1(1), IL23A(1), IL23R(4), IL24(1), IL26(1), IL28A(1), IL28B(1), IL28RA(1), IL2RA(1), IL2RB(2), IL2RG(3), IL3RA(3), IL4R(1), IL5RA(2), IL6(2), IL6R(1), IL6ST(3), IL7(1), IL7R(2), IL9R(1), IRF9(2), JAK1(3), JAK2(2), JAK3(3), LEPR(4), LIFR(3), MPL(1), MYC(1), OSM(2), OSMR(3), PIAS3(1), PIAS4(2), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PRL(2), PRLR(1), SOCS5(1), SOCS7(1), SOS1(5), SOS2(4), SPRED1(2), SPRED2(2), SPRY1(1), SPRY4(2), STAM(1), STAM2(4), STAT1(4), STAT2(2), STAT4(1), STAT5B(2), STAT6(3), TPO(9), TYK2(2) 28078660 255 106 239 78 124 10 48 30 43 0 0.536 1.000 1.000 352 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(2), ADORA1(1), ADRA1A(4), ADRA1B(1), ADRA2C(1), ADRB1(1), ADRB2(2), AGTR2(1), AVPR1A(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BRS3(1), CALCR(2), CALCRL(2), CCKBR(3), CHRM1(1), CHRM3(4), CHRM4(1), CNR1(1), CNR2(3), CRHR2(1), CTSG(3), CYSLTR2(1), DRD3(1), EDNRA(1), EDNRB(2), F2R(2), F2RL1(3), F2RL3(1), FPR1(1), FSHR(1), GABBR1(2), GABBR2(3), GABRA1(1), GABRA2(1), GABRA3(1), GABRA4(5), GABRA5(3), GABRA6(3), GABRB1(2), GABRB2(3), GABRB3(2), GABRE(1), GABRG1(5), GABRG2(2), GABRG3(2), GABRP(1), GABRR1(2), GABRR2(1), GALR1(1), GALR2(3), GALR3(1), GHR(2), GHRHR(1), GHSR(1), GIPR(1), GLP2R(1), GLRA1(1), GLRA2(1), GLRA3(2), GLRB(2), GPR156(2), GPR50(5), GPR63(2), GPR83(1), GRIA1(3), GRIA2(3), GRIA3(2), GRIA4(5), GRID1(2), GRID2(2), GRIK1(7), GRIK2(4), GRIK3(4), GRIK4(2), GRIK5(2), GRIN1(6), GRIN2A(9), GRIN2B(3), GRIN2C(5), GRIN2D(2), GRIN3A(2), GRM1(7), GRM2(5), GRM3(3), GRM4(1), GRM5(5), GRM6(4), GRM7(4), GRM8(1), GZMA(4), HCRTR2(2), HRH1(4), HRH4(1), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(1), HTR1F(1), HTR2B(2), HTR2C(1), HTR4(2), HTR6(1), HTR7(1), LEPR(4), LHCGR(2), LTB4R2(2), MC3R(1), MC4R(2), MCHR2(1), MLNR(1), MTNR1A(1), NMBR(3), NPBWR2(1), NPFFR1(2), NPFFR2(3), NPY1R(1), NPY5R(4), NR3C1(1), NTSR1(1), OPRD1(2), OXTR(1), P2RX1(2), P2RX2(1), P2RX3(2), P2RX7(1), P2RY1(1), P2RY10(1), P2RY13(2), P2RY2(1), PARD3(6), PRL(2), PRLR(1), PTAFR(1), PTGDR(3), PTGER2(1), PTGER3(1), PTGER4(2), PTGFR(2), PTGIR(1), PTH2R(2), RXFP1(2), RXFP2(2), SCTR(3), SSTR1(1), SSTR3(2), SSTR4(3), TAAR5(1), TAAR8(3), TAAR9(1), TACR1(2), TACR3(1), TRHR(2), TRPV1(2), TSHR(2), UTS2R(1), VIPR1(1), VIPR2(4) 42744573 335 105 334 162 156 13 98 32 36 0 0.958 1.000 1.000 353 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(3), CD36(1), CD47(1), COL11A1(10), COL11A2(3), COL1A1(2), COL1A2(4), COL2A1(4), COL4A1(3), COL4A2(5), COL4A4(4), COL4A6(1), COL5A1(8), COL5A2(5), COL5A3(3), COL6A2(1), COL6A3(10), COL6A6(10), DAG1(1), FN1(6), FNDC1(8), FNDC3A(6), GP5(1), GP6(1), HSPG2(8), IBSP(1), ITGA1(1), ITGA10(1), ITGA11(4), ITGA2(3), ITGA2B(7), ITGA3(4), ITGA4(6), ITGA5(3), ITGA6(2), ITGA7(2), ITGA8(5), ITGA9(3), ITGAV(3), ITGB1(1), ITGB3(2), ITGB4(5), ITGB5(2), ITGB8(1), LAMA1(6), LAMA2(14), LAMA3(17), LAMA4(5), LAMA5(8), LAMB1(5), LAMB2(4), LAMB3(3), LAMB4(3), LAMC1(5), LAMC2(2), LAMC3(4), RELN(13), SDC1(2), SDC3(1), SPP1(1), SV2A(2), SV2B(5), SV2C(1), THBS2(6), THBS3(2), THBS4(2), TNC(5), TNN(2), TNR(7), TNXB(11), VTN(2), VWF(7) 43348280 310 104 308 119 157 12 70 35 36 0 0.994 1.000 1.000 354 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTB(5), ACTG1(4), ACTN1(2), ACTN2(3), ACTN3(2), ACTN4(4), AKT3(1), AMOTL1(6), ASH1L(13), CASK(1), CDK4(2), CGN(2), CLDN1(1), CLDN10(1), CLDN17(2), CLDN19(1), CLDN2(1), CLDN23(1), CLDN4(1), CLDN5(1), CLDN6(1), CLDN8(1), CSDA(1), CSNK2A1(4), CSNK2B(2), CTNNA1(1), CTNNA2(2), CTNNA3(3), CTNNB1(4), CTTN(2), EPB41(5), EPB41L1(4), EPB41L3(6), EXOC3(2), EXOC4(5), F11R(1), GNAI1(1), GNAI3(2), HCLS1(1), HRAS(6), IGSF5(2), INADL(5), JAM2(1), JAM3(1), LLGL1(1), LLGL2(1), MAGI1(4), MAGI2(7), MAGI3(7), MLLT4(3), MPDZ(12), MPP5(2), MYH1(5), MYH10(7), MYH11(4), MYH13(6), MYH14(1), MYH15(6), MYH2(5), MYH3(7), MYH4(5), MYH6(3), MYH7(8), MYH7B(6), MYH8(3), MYH9(13), MYL2(2), MYLPF(1), NRAS(2), OCLN(3), PARD3(6), PARD6A(3), PARD6B(1), PARD6G(1), PPM1J(1), PPP2CA(1), PPP2R1A(1), PPP2R1B(3), PPP2R2B(1), PPP2R2C(1), PPP2R3A(7), PRKCA(1), PRKCD(1), PRKCG(2), PRKCI(1), PRKCQ(1), PRKCZ(2), PTEN(5), RAB3B(1), RHOA(5), RRAS(1), SPTAN1(34), SRC(4), SYMPK(4), TJAP1(1), TJP1(3), TJP2(5), VAPA(2), YES1(1), ZAK(1) 37493611 342 104 340 108 188 18 56 27 53 0 0.671 1.000 1.000 355 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1B(1), ACVR2A(2), AMHR2(1), BMPR1A(1), BMPR1B(2), BMPR2(5), CCL1(3), CCL13(1), CCL14(1), CCL15(1), CCL16(1), CCL21(1), CCL23(1), CCL25(1), CCL3(1), CCR1(1), CCR3(3), CCR4(2), CCR5(2), CCR7(3), CCR8(1), CD27(1), CD40(1), CLCF1(2), CNTF(1), CNTFR(1), CSF1(2), CSF1R(6), CSF2RA(1), CSF2RB(1), CSF3R(2), CX3CL1(5), CX3CR1(3), CXCL11(1), CXCL13(1), CXCL14(1), CXCL5(1), CXCL6(1), CXCR3(1), CXCR4(2), EDA(1), EGF(4), EGFR(3), EPOR(1), FLT1(1), FLT3(3), FLT4(1), GDF5(1), GHR(2), HGF(1), IFNA16(1), IFNA4(3), IFNAR1(1), IFNAR2(1), IFNG(1), IFNGR2(2), IL10RA(4), IL10RB(3), IL12B(2), IL12RB1(2), IL12RB2(1), IL13RA1(1), IL17A(1), IL17B(3), IL17RA(1), IL18R1(1), IL18RAP(6), IL19(2), IL1A(1), IL1B(1), IL1RAP(1), IL20RA(1), IL21(1), IL21R(5), IL22RA1(1), IL23A(1), IL23R(4), IL24(1), IL26(1), IL28A(1), IL28B(1), IL28RA(1), IL2RA(1), IL2RB(2), IL2RG(3), IL3RA(3), IL4R(1), IL5RA(2), IL6(2), IL6R(1), IL6ST(3), IL7(1), IL7R(2), IL8(1), IL9R(1), INHBB(1), INHBE(2), KDR(9), KIT(3), KITLG(2), LEPR(4), LIFR(3), MET(5), MPL(1), NGFR(3), OSM(2), OSMR(3), PDGFB(1), PDGFRA(7), PDGFRB(4), PLEKHO2(3), PPBP(2), PRL(2), PRLR(1), TGFB3(1), TGFBR2(3), TNFRSF10A(4), TNFRSF10C(1), TNFRSF10D(1), TNFRSF13C(1), TNFRSF1B(3), TNFRSF21(3), TNFRSF25(3), TNFRSF4(1), TNFRSF8(4), TNFRSF9(2), TNFSF10(2), TNFSF11(1), TNFSF13B(3), TNFSF14(1), TNFSF4(1), TNFSF8(3), TPO(9), VEGFB(2), VEGFC(1) 34218925 275 101 274 100 133 5 72 35 30 0 0.789 1.000 1.000 356 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(3), ACTA2(3), ACTN2(3), ACTN3(2), ACTN4(4), DMD(7), FAM48A(2), MYBPC1(5), MYBPC2(2), MYBPC3(2), MYH3(7), MYH6(3), MYH7(8), MYH8(3), MYL2(2), MYOM1(5), NEB(15), TCAP(1), TMOD1(1), TNNI1(2), TNNI2(1), TNNI3(1), TNNT1(3), TPM1(1), TPM2(2), TTN(140), VIM(2) 25820783 230 101 230 60 113 8 57 36 16 0 0.356 1.000 1.000 357 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(19), CCNA1(1), CCNB1(1), CCND1(1), CCND3(5), CCNE2(1), CCNH(3), CDC25A(1), CDK2(1), CDK4(2), CDK7(3), CDKN1A(18), CDKN1B(5), CDKN2A(8), CDKN2B(2), CDKN2D(1), CREB3L3(5), CREB3L4(2), E2F1(1), E2F2(1), E2F3(2), E2F4(1), E2F5(1), E2F6(1), GADD45A(1), MCM2(1), MCM3(1), MCM4(4), MCM6(2), MNAT1(1), MYC(1), MYT1(3), NACA(1), ORC1L(1), ORC3L(3), PCNA(1), POLA2(3), POLE(6), POLE2(1), RB1(19), RBL1(1), RPA3(3), TNXB(11), TP53(75), WEE1(2) 14875088 227 99 199 44 83 4 54 14 72 0 0.0245 1.000 1.000 358 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(4), ABLIM1(3), ABLIM2(1), ABLIM3(1), ARHGEF12(4), CDK5(1), CFL2(1), CXCR4(2), DCC(8), DPYSL2(1), EFNA5(1), EFNB1(1), EFNB2(1), EFNB3(1), EPHA1(3), EPHA2(8), EPHA3(1), EPHA5(5), EPHA6(3), EPHA7(2), EPHA8(3), EPHB1(4), EPHB2(3), EPHB3(1), EPHB4(3), EPHB6(3), FES(1), FYN(1), GNAI1(1), GNAI3(2), HRAS(6), ITGB1(1), L1CAM(2), LIMK1(2), LRRC4C(1), MAPK3(3), MET(5), NCK1(1), NFAT5(7), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), NGEF(1), NRAS(2), NRP1(2), NTN1(4), NTN4(1), NTNG1(3), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PAK7(2), PLXNA1(1), PLXNA2(2), PLXNB1(1), PLXNB2(8), PLXNB3(3), PLXNC1(2), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(2), PTK2(3), RAC1(1), RASA1(4), RGS3(1), RHOA(5), RND1(2), ROBO1(6), ROBO2(6), ROBO3(2), ROCK1(4), ROCK2(6), SEMA3A(6), SEMA3B(2), SEMA3C(2), SEMA3D(7), SEMA3E(1), SEMA3F(3), SEMA3G(2), SEMA4A(3), SEMA4B(3), SEMA4C(1), SEMA4D(1), SEMA4F(2), SEMA4G(1), SEMA5A(6), SEMA5B(7), SEMA6B(2), SEMA6C(6), SEMA6D(4), SLIT1(2), SLIT3(4), SRGAP1(1), SRGAP2(3), SRGAP3(1), UNC5A(3), UNC5B(1), UNC5C(2), UNC5D(3) 38055970 286 99 285 103 137 10 75 35 29 0 0.811 1.000 1.000 359 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(3), ADCY2(10), ADCY3(2), ADCY4(2), ADCY5(1), ADCY6(4), ADCY7(1), ADCY8(5), ADCY9(3), ADRA1A(4), ADRA1B(1), ADRA1D(2), ADRB1(1), ADRB2(2), ANXA6(3), ARRB1(1), ATP1A4(5), ATP1B2(3), ATP2A2(2), ATP2A3(2), ATP2B1(5), ATP2B2(5), ATP2B3(1), CACNA1A(6), CACNA1B(2), CACNA1C(5), CACNA1D(5), CACNA1E(4), CACNA1S(5), CACNB1(2), CALM1(1), CALM2(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), CAMK4(1), CASQ1(2), CASQ2(1), CHRM1(1), CHRM3(4), CHRM4(1), GJA1(1), GNAI3(2), GNAO1(2), GNAZ(1), GNB1(5), GNB3(3), GNB4(1), GNB5(2), GNG2(1), GNG4(4), GRK5(2), GRK6(1), ITPR1(7), ITPR2(9), ITPR3(4), KCNB1(3), KCNJ3(1), KCNJ5(1), MIB1(4), NME7(1), PKIA(1), PKIG(1), PLCB3(6), PLN(1), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(1), PRKCD(1), PRKCG(2), PRKCQ(1), PRKCZ(2), PRKD1(2), RGS10(1), RGS14(2), RGS16(3), RGS18(2), RGS19(1), RGS2(1), RGS3(1), RGS4(1), RGS5(2), RGS6(1), RGS7(4), RGS9(1), RYR1(12), RYR2(21), RYR3(14), SFN(1), SLC8A1(2), SLC8A3(2), USP5(1), YWHAB(2), YWHAQ(1) 36164884 271 96 270 127 129 13 76 30 23 0 0.987 1.000 1.000 360 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(2), ACTN2(3), ACTN3(2), ACTN4(4), ARHGAP5(8), CDH5(4), CLDN1(1), CLDN10(1), CLDN17(2), CLDN19(1), CLDN2(1), CLDN23(1), CLDN4(1), CLDN5(1), CLDN6(1), CLDN8(1), CTNNA1(1), CTNNA2(2), CTNNA3(3), CTNNB1(4), CXCR4(2), EZR(6), F11R(1), GNAI1(1), GNAI3(2), GRLF1(14), ICAM1(3), ITGA4(6), ITGAL(2), ITGAM(3), ITGB1(1), ITGB2(3), ITK(2), JAM2(1), JAM3(1), MAPK11(2), MAPK12(1), MAPK13(1), MAPK14(1), MLLT4(3), MMP2(2), MMP9(3), MYL2(2), MYLPF(1), NCF2(4), NCF4(2), NOX1(1), OCLN(3), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PLCG1(3), PLCG2(3), PRKCA(1), PRKCG(2), PTK2(3), PTK2B(3), RAC1(1), RAP1A(1), RAP1B(2), RAPGEF4(4), RHOA(5), RHOH(1), ROCK1(4), ROCK2(6), SIPA1(3), TXK(4), VAV1(2), VAV2(1), VAV3(2), VCAM1(1), VCL(1) 24010358 211 96 196 58 114 7 39 22 29 0 0.178 1.000 1.000 361 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(3), ACTA2(3), ADCY1(3), ADCY2(10), ADCY3(2), ADCY4(2), ADCY5(1), ADCY6(4), ADCY7(1), ADCY8(5), ADCY9(3), ADM(3), ARRB1(1), ATF1(1), ATP2A2(2), ATP2A3(2), CALM1(1), CALM2(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), CNN1(2), CNN2(2), DGKZ(3), FOS(3), GABPA(4), GJA1(1), GNB1(5), GNB3(3), GNB4(1), GNB5(2), GNG2(1), GNG4(4), GRK5(2), GRK6(1), GSTO1(1), GUCY1A3(6), IL1B(1), IL6(2), ITPR1(7), ITPR2(9), ITPR3(4), MAFF(1), MIB1(4), MYL2(2), MYLK2(4), NFKB1(1), NOS1(4), NOS3(6), OXTR(1), PDE4B(1), PDE4D(2), PKIA(1), PKIG(1), PLCB3(6), PLCD1(1), PLCG1(3), PLCG2(3), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(1), PRKCD(1), PRKCQ(1), PRKCZ(2), PRKD1(2), RAMP1(1), RGS10(1), RGS14(2), RGS16(3), RGS18(2), RGS19(1), RGS2(1), RGS3(1), RGS4(1), RGS5(2), RGS6(1), RGS7(4), RGS9(1), RLN1(1), RYR1(12), RYR2(21), RYR3(14), SFN(1), SLC8A1(2), SP1(3), TNXB(11), USP5(1), YWHAB(2), YWHAQ(1) 33396247 263 96 262 108 133 12 66 29 23 0 0.912 1.000 1.000 362 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(4), ABL2(1), AKT3(1), ARAF(1), BRAF(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), CBL(4), CBLB(6), CDKN1A(18), CDKN1B(5), EGF(4), EGFR(3), EIF4EBP1(1), ERBB2(11), ERBB3(14), ERBB4(3), GAB1(2), HRAS(6), MAP2K1(1), MAP2K4(1), MAP2K7(2), MAPK10(1), MAPK3(3), MAPK8(4), MAPK9(5), MYC(1), NCK1(1), NRAS(2), NRG1(5), NRG3(3), NRG4(1), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PAK7(2), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PLCG1(3), PLCG2(3), PRKCA(1), PRKCG(2), PTK2(3), RAF1(1), SHC2(1), SHC4(4), SOS1(5), SOS2(4), SRC(4), STAT5B(2) 19916603 203 95 181 53 101 9 42 23 28 0 0.264 1.000 1.000 363 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AKT3(1), APAF1(1), ATM(19), BAX(1), BCL2L1(2), BIRC3(1), CASP3(1), CASP6(1), CASP8(4), CASP9(3), CFLAR(1), CHUK(6), CSF2RB(1), DFFA(4), FADD(1), IKBKB(4), IL1A(1), IL1B(1), IL1RAP(1), IL3RA(3), IRAK2(1), IRAK3(3), IRAK4(3), MAP3K14(2), MYD88(1), NFKB1(1), NFKB2(1), NFKBIA(2), NTRK1(4), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(2), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), RELA(2), RIPK1(2), TNFRSF10A(4), TNFRSF10C(1), TNFRSF10D(1), TNFSF10(2), TP53(75), TRADD(1), TRAF2(2) 16141988 225 95 185 43 101 7 58 20 39 0 0.00330 1.000 1.000 364 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACTB(5), ACTG1(4), ACTN1(2), ACTN2(3), ACTN3(2), ACTN4(4), ACVR1B(1), ACVR1C(1), CDH1(6), CREBBP(18), CSNK2A1(4), CSNK2B(2), CTNNA1(1), CTNNA2(2), CTNNA3(3), CTNNB1(4), EGFR(3), EP300(26), ERBB2(11), FARP2(2), FER(4), FGFR1(3), FYN(1), IGF1R(5), INSR(4), IQGAP1(3), LEF1(2), LMO7(4), MAP3K7(3), MAPK3(3), MET(5), MLLT4(3), NLK(2), PARD3(6), PTPRB(5), PTPRF(4), PTPRJ(2), PTPRM(2), PVRL1(4), PVRL2(2), PVRL3(2), PVRL4(2), RAC1(1), RHOA(5), SMAD2(2), SMAD3(5), SMAD4(2), SNAI1(1), SORBS1(4), SRC(4), SSX2IP(1), TGFBR2(3), TJP1(3), VCL(1), WAS(1), WASF2(3), WASF3(1), WASL(1), YES1(1) 23167340 214 95 211 62 104 7 47 21 35 0 0.521 1.000 1.000 365 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(2), CADM1(1), CADM3(1), CD2(1), CD22(2), CD226(3), CD276(1), CD34(2), CD4(1), CD40(1), CD58(1), CD6(2), CD86(1), CD8A(2), CDH1(6), CDH15(3), CDH2(1), CDH3(1), CDH4(7), CDH5(4), CLDN1(1), CLDN10(1), CLDN17(2), CLDN19(1), CLDN2(1), CLDN23(1), CLDN4(1), CLDN5(1), CLDN6(1), CLDN8(1), CNTN1(4), CNTNAP2(8), F11R(1), GLG1(1), HLA-A(5), HLA-C(2), HLA-DMB(1), HLA-DQA1(1), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(1), HLA-DRB1(1), HLA-E(1), HLA-F(1), ICAM1(3), ICAM3(2), ICOS(2), ICOSLG(1), ITGA4(6), ITGA6(2), ITGA8(5), ITGA9(3), ITGAL(2), ITGAM(3), ITGAV(3), ITGB1(1), ITGB2(3), ITGB8(1), JAM2(1), JAM3(1), L1CAM(2), MADCAM1(1), MAG(1), MPZ(4), NCAM1(3), NCAM2(3), NEGR1(1), NEO1(3), NFASC(2), NLGN1(2), NRCAM(1), NRXN1(8), NRXN2(3), NRXN3(3), OCLN(3), PDCD1(1), PDCD1LG2(1), PTPRC(5), PTPRF(4), PTPRM(2), PVR(2), PVRL1(4), PVRL2(2), PVRL3(2), SDC1(2), SDC3(1), SELE(1), SELP(1), SPN(1), VCAM1(1), VCAN(9) 28500766 202 93 201 86 89 4 52 25 32 0 0.989 1.000 1.000 366 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(13), ACACB(5), AKT3(1), ARAF(1), BRAF(1), CALM1(1), CALM2(1), CALML3(1), CALML6(1), CBL(4), CBLB(6), EIF4EBP1(1), EXOC7(2), FASN(2), FBP1(1), FOXO1(1), GYS1(3), GYS2(3), HRAS(6), IKBKB(4), INPP5D(2), INSR(4), IRS1(3), IRS2(3), IRS4(8), LIPE(5), MAP2K1(1), MAPK10(1), MAPK3(3), MAPK8(4), MAPK9(5), MKNK1(1), NRAS(2), PCK1(3), PDE3A(5), PDE3B(1), PDPK1(1), PFKP(1), PHKA1(5), PHKA2(1), PHKB(1), PHKG2(2), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PKLR(1), PKM2(2), PPARGC1A(2), PPP1CA(4), PPP1CB(3), PPP1R3A(4), PPP1R3B(2), PPP1R3C(1), PPP1R3D(1), PRKAA2(4), PRKAB2(1), PRKACB(1), PRKAG1(2), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCI(1), PRKCZ(2), PRKX(1), PTPRF(4), PYGL(1), PYGM(4), RAF1(1), RHEB(1), RHOQ(1), RPS6(3), SHC2(1), SHC4(4), SLC2A4(1), SORBS1(4), SOS1(5), SOS2(4), SREBF1(4), TRIP10(2), TSC1(11), TSC2(2) 31021361 251 93 233 86 138 8 51 25 29 0 0.731 1.000 1.000 367 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(5), CABIN1(3), CALM1(1), CALM2(1), CAMK2B(2), CAMK4(1), CD3E(1), CDKN1A(18), CEBPB(3), CNR1(1), CREBBP(18), CSNK2A1(4), CSNK2B(2), EGR2(1), EGR3(1), EP300(26), FCER1A(2), FOS(3), FOSL1(1), GATA3(1), GRLF1(14), GSK3A(1), HRAS(6), ICOS(2), IFNG(1), IL1B(1), IL2RA(1), IL6(2), IL8(1), ITK(2), JUNB(4), KPNA5(1), MAP2K7(2), MAPK14(1), MAPK8(4), MAPK9(5), MEF2A(1), MEF2D(1), MYF5(1), NFAT5(7), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), NFKB2(1), NFKBIB(4), NFKBIE(5), NPPB(1), NUP214(3), OPRD1(2), P2RX7(1), PPIA(1), PPP3CB(4), PPP3CC(2), PPP3R1(1), PTPRC(5), RELA(2), SFN(1), SLA(1), SP1(3), SP3(2), TRAF2(2), TRPV6(2), VAV1(2), VAV2(1), VAV3(2), XPO5(6) 17591516 220 91 216 51 86 8 46 21 59 0 0.103 1.000 1.000 368 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(1), BRAF(1), CASP3(1), CD244(2), CD247(1), FCGR3B(3), FYN(1), HCST(1), HLA-A(5), HLA-C(2), HLA-E(1), HRAS(6), ICAM1(3), IFNA16(1), IFNA4(3), IFNAR1(1), IFNAR2(1), IFNG(1), IFNGR2(2), ITGAL(2), ITGB2(3), KIR2DL1(1), KIR2DL3(1), KIR3DL1(2), KLRD1(1), LAT(1), LCK(1), MAP2K1(1), MAPK3(3), MICA(2), MICB(1), NCR1(2), NCR2(2), NFAT5(7), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), NRAS(2), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PLCG1(3), PLCG2(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(2), PRF1(4), PRKCA(1), PRKCG(2), PTK2B(3), RAC1(1), RAF1(1), SH2D1B(1), SH3BP2(1), SHC2(1), SHC4(4), SOS1(5), SOS2(4), SYK(1), TNFRSF10A(4), TNFRSF10C(1), TNFRSF10D(1), TNFSF10(2), ULBP1(1), ULBP3(1), VAV1(2), VAV2(1), VAV3(2), ZAP70(1) 21882340 186 90 169 57 97 8 31 26 24 0 0.452 1.000 1.000 369 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM1(1), CALM2(1), CALML3(1), CALML6(1), CDS1(2), DGKA(1), DGKB(2), DGKD(3), DGKE(1), DGKG(4), DGKH(2), DGKI(5), DGKQ(2), DGKZ(3), FN3K(2), IMPA1(1), IMPA2(1), INPP1(1), INPP4A(1), INPP4B(4), INPP5A(3), INPP5B(1), INPP5D(2), INPPL1(2), ITPK1(1), ITPKA(2), ITPKB(1), ITPR1(7), ITPR2(9), ITPR3(4), PI4KB(3), PIK3C2A(7), PIK3C2B(6), PIK3C2G(3), PIK3C3(5), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIP4K2A(2), PIP4K2B(1), PIP4K2C(3), PIP5K1A(5), PIP5K1C(2), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PLCD1(1), PLCD3(1), PLCD4(2), PLCE1(2), PLCG1(3), PLCG2(3), PLCZ1(2), PRKCA(1), PRKCG(2), PTEN(5), PTPMT1(1), SYNJ1(3), SYNJ2(2) 24044779 189 89 173 71 109 7 34 22 17 0 0.875 1.000 1.000 370 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(4), ACTN1(2), ACTR3(1), AKT3(1), ARHGEF6(2), ARHGEF7(3), BRAF(1), CDKN2A(8), CSE1L(5), DOCK1(4), EPHB2(3), FYN(1), GRB7(1), GRLF1(14), ITGA1(1), ITGA10(1), ITGA11(4), ITGA2(3), ITGA3(4), ITGA4(6), ITGA5(3), ITGA6(2), ITGA7(2), ITGA8(5), ITGA9(3), MAP2K4(1), MAP2K7(2), MAPK10(1), MAPK8(4), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(3), MAPK9(5), MYLK(5), MYLK2(4), P4HB(3), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PAK7(2), PIK3CA(26), PIK3CB(5), PKLR(1), PLCG1(3), PLCG2(3), PTEN(5), PTK2(3), RAF1(1), ROCK1(4), ROCK2(6), SOS1(5), SOS2(4), SRC(4), TERF2IP(2), TLN1(2), TLN2(5), WAS(1), ZYX(1) 23620702 206 89 191 53 116 6 35 21 28 0 0.153 1.000 1.000 371 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(3), ADCY2(10), ADCY3(2), ADCY4(2), ADCY5(1), ADCY6(4), ADCY7(1), ADCY8(5), ADCY9(3), ADRB1(1), EGF(4), EGFR(3), GJA1(1), GJD2(2), GNAI1(1), GNAI3(2), GNAS(4), GRM1(7), GRM5(5), GUCY1A2(4), GUCY1A3(6), GUCY1B3(3), GUCY2C(3), GUCY2D(3), GUCY2F(2), HRAS(6), HTR2B(2), HTR2C(1), ITPR1(7), ITPR2(9), ITPR3(4), MAP2K1(1), MAP3K2(2), MAPK3(3), MAPK7(2), NRAS(2), PDGFB(1), PDGFRA(7), PDGFRB(4), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PRKACB(1), PRKCA(1), PRKCG(2), PRKG1(1), PRKG2(4), PRKX(1), RAF1(1), SOS1(5), SOS2(4), SRC(4), TJP1(3), TUBA1A(2), TUBA1C(1), TUBA3C(3), TUBA3D(2), TUBA3E(1), TUBA8(1), TUBAL3(1), TUBB(1), TUBB2C(1), TUBB3(5), TUBB4(2), TUBB6(2), TUBB8(2) 25540838 197 88 195 75 93 8 62 20 14 0 0.760 1.000 1.000 372 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(3), ADCY8(5), ARAF(1), BRAF(1), CACNA1C(5), CALM1(1), CALM2(1), CALML3(1), CALML6(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), CAMK4(1), CREBBP(18), EP300(26), GRIA1(3), GRIA2(3), GRIN1(6), GRIN2A(9), GRIN2B(3), GRIN2C(5), GRIN2D(2), GRM1(7), GRM5(5), HRAS(6), ITPR1(7), ITPR2(9), ITPR3(4), MAP2K1(1), MAPK3(3), NRAS(2), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PPP1CA(4), PPP1CB(3), PPP1R12A(4), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(2), PRKACB(1), PRKCA(1), PRKCG(2), PRKX(1), RAF1(1), RAP1A(1), RAP1B(2), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), RPS6KA6(2) 19220044 199 88 196 54 80 13 51 29 26 0 0.129 1.000 1.000 373 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 ALG2(2), BAX(1), BFAR(2), BTK(3), CAD(7), CASP3(1), CASP8(4), CASP8AP2(7), CD7(2), CSNK1A1(3), DAXX(1), DFFA(4), EGFR(3), EPHB2(3), FADD(1), FAF1(1), IL1A(1), IL8(1), MAP2K4(1), MAP2K7(2), MAP3K1(3), MAP3K5(4), MAPK10(1), MAPK8(4), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(3), MAPK9(5), MET(5), NFAT5(7), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), NFKBIL2(2), PFN1(2), PTPN13(7), RALBP1(1), RIPK1(2), ROCK1(4), SMPD1(3), TP53(75), TPX2(1), TRAF2(2) 14015354 198 87 173 37 87 2 59 16 34 0 0.00573 1.000 1.000 374 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(1), BAX(1), BCL2L1(2), BIRC3(1), BIRC5(1), CASP1(2), CASP3(1), CASP4(2), CASP6(1), CASP8(4), CASP9(3), CHUK(6), DFFA(4), FADD(1), HELLS(1), IKBKB(4), IRF1(1), IRF2(1), IRF4(1), IRF5(1), IRF6(3), IRF7(1), MAP2K4(1), MAP3K1(3), MAPK10(1), MYC(1), NFKB1(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), PLEKHG5(2), PRF1(4), RELA(2), RIPK1(2), TNFRSF1B(3), TNFRSF21(3), TNFRSF25(3), TNFSF10(2), TP53(75), TP73(2), TRADD(1), TRAF2(2) 11104849 162 86 137 31 57 2 60 11 32 0 0.0128 1.000 1.000 375 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADCY1(3), ADCY2(10), ADCY3(2), ADCY4(2), ADCY5(1), ADCY6(4), ADCY7(1), ADCY8(5), ADCY9(3), ADK(3), ADSL(1), ADSS(2), AK3L1(1), AK7(2), ALLC(1), AMPD1(2), AMPD2(1), AMPD3(3), ATIC(1), DCK(1), ENPP1(2), ENTPD2(1), ENTPD3(3), ENTPD5(1), ENTPD6(1), ENTPD8(1), GART(1), GDA(3), GMPS(2), GUCY1A2(4), GUCY1A3(6), GUCY1B3(3), GUCY2C(3), GUCY2D(3), GUCY2F(2), IMPDH1(1), IMPDH2(2), NME4(1), NME7(1), NT5C1A(3), NT5C1B(3), NT5C2(2), NT5C3(2), NT5E(3), PDE10A(2), PDE11A(8), PDE1A(2), PDE1C(4), PDE2A(1), PDE3B(1), PDE4A(1), PDE4B(1), PDE4C(2), PDE4D(2), PDE5A(5), PDE6G(1), PDE6H(1), PDE7A(2), PDE7B(1), PDE8A(1), PDE9A(4), PFAS(1), PKLR(1), PKM2(2), PNPT1(3), POLA1(2), POLA2(3), POLD1(3), POLD2(3), POLD3(3), POLE(6), POLE2(1), POLR1A(5), POLR1B(1), POLR1C(1), POLR1D(2), POLR2B(1), POLR2C(2), POLR2D(1), POLR2E(1), POLR2F(1), POLR3A(5), POLR3B(3), POLR3H(1), PPAT(2), PRIM2(2), PRUNE(4), RRM1(1), RRM2(2), XDH(6) 31522643 211 86 211 84 107 7 53 21 23 0 0.958 1.000 1.000 376 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1B(1), ACVR1C(1), ACVR2A(2), ACVRL1(3), AMHR2(1), BMP4(1), BMP5(1), BMP6(1), BMP8B(1), BMPR1A(1), BMPR1B(2), BMPR2(5), CDKN2B(2), CHRD(5), COMP(5), CREBBP(18), CUL1(8), E2F4(1), E2F5(1), EP300(26), FST(2), GDF5(1), GDF6(3), ID1(1), IFNG(1), INHBB(1), INHBE(2), LTBP1(5), MAPK3(3), MYC(1), NODAL(1), NOG(1), PPP2CA(1), PPP2R1A(1), PPP2R1B(3), PPP2R2B(1), PPP2R2C(1), RBL1(1), RBL2(3), RHOA(5), ROCK1(4), ROCK2(6), SKP1(1), SMAD1(1), SMAD2(2), SMAD3(5), SMAD4(2), SMAD6(1), SMAD7(2), SMAD9(2), SMURF1(4), SMURF2(1), SP1(3), TGFB3(1), TGFBR2(3), THBS2(6), THBS3(2), THBS4(2), ZFYVE16(4), ZFYVE9(6) 19121656 182 86 180 48 80 9 41 21 31 0 0.355 1.000 1.000 377 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA1(1), ADRA1A(4), ADRA1B(1), ADRA1D(2), ADRA2C(1), ADRB1(1), ADRB2(2), AGTR2(1), AVPR1A(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BRS3(1), CCBP2(1), CCKBR(3), CCR1(1), CCR10(1), CCR3(3), CCR4(2), CCR5(2), CCR7(3), CCR8(1), CCRL1(1), CCRL2(1), CHML(2), CHRM1(1), CHRM3(4), CHRM4(1), CNR1(1), CNR2(3), CX3CR1(3), CXCR3(1), CXCR4(2), DRD3(1), EDNRA(1), EDNRB(2), F2R(2), F2RL1(3), F2RL3(1), FPR1(1), FSHR(1), GALR1(1), GALR2(3), GALR3(1), GALT(1), GHSR(1), GPR17(3), GPR173(1), GPR174(1), GPR37(2), GPR37L1(3), GPR4(2), GPR50(5), GPR63(2), GPR77(1), GPR83(1), GPR87(2), HCRTR2(2), HRH1(4), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(1), HTR1F(1), HTR2B(2), HTR2C(1), HTR4(2), HTR6(1), HTR7(1), LHCGR(2), MC3R(1), MC4R(2), MLNR(1), MTNR1A(1), NMBR(3), NPY1R(1), NPY5R(4), NTSR1(1), OPN1SW(1), OPRD1(2), OR10A5(2), OR11A1(1), OR1C1(2), OR1F1(1), OR1Q1(1), OR7A5(3), OR7C1(3), OR8B8(2), OXTR(1), P2RY1(1), P2RY10(1), P2RY13(2), P2RY2(1), PTAFR(1), PTGDR(3), PTGER2(1), PTGER4(2), PTGFR(2), PTGIR(1), RRH(1), SSTR1(1), SSTR3(2), SSTR4(3), SUCNR1(1), TRHR(2) 23466006 176 84 176 102 78 9 58 20 11 0 0.976 1.000 1.000 378 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT3(1), BCL10(1), CARD11(5), CBL(4), CBLB(6), CD247(1), CD3E(1), CD4(1), CD8A(2), CDK4(2), CHUK(6), FOS(3), FYN(1), GRAP2(2), HRAS(6), ICOS(2), IFNG(1), IKBKB(4), ITK(2), LAT(1), LCK(1), MALT1(5), MAP3K14(2), MAP3K8(2), NCK1(1), NFAT5(7), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), NRAS(2), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PAK7(2), PDCD1(1), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(2), PRKCQ(1), PTPRC(5), RASGRP1(1), RHOA(5), SOS1(5), SOS2(4), TEC(4), VAV1(2), VAV2(1), VAV3(2), ZAP70(1) 19600343 195 84 179 49 108 9 30 25 23 0 0.154 1.000 1.000 379 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(3), ADCY2(10), ADCY3(2), ADCY4(2), ADCY5(1), ADCY6(4), ADCY7(1), ADCY8(5), ADCY9(3), CALM1(1), CALM2(1), CALML3(1), CALML6(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), CREB3L2(1), CREB3L3(5), CREB3L4(2), CREBBP(18), CTNNB1(4), DCT(3), DVL2(2), DVL3(1), EDNRB(2), EP300(26), FZD10(1), FZD3(3), FZD4(1), FZD6(4), FZD7(2), FZD8(1), FZD9(2), GNAI1(1), GNAI3(2), GNAO1(2), GNAS(4), HRAS(6), KIT(3), KITLG(2), LEF1(2), MAP2K1(1), MAPK3(3), MITF(1), NRAS(2), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PRKACB(1), PRKCA(1), PRKCG(2), PRKX(1), RAF1(1), TYR(3), WNT2(2), WNT3A(1), WNT5A(1), WNT6(1), WNT7A(2), WNT7B(1), WNT8A(1) 21056535 179 83 176 75 73 7 56 23 20 0 0.931 1.000 1.000 380 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT3(1), CASP8(4), CCL3(1), CD40(1), CD86(1), CHUK(6), CXCL11(1), FADD(1), FOS(3), IFNA16(1), IFNA4(3), IFNAR1(1), IFNAR2(1), IKBKB(4), IKBKE(2), IL12B(2), IL1B(1), IL6(2), IL8(1), IRAK4(3), IRF5(1), IRF7(1), LY96(1), MAP2K1(1), MAP2K3(2), MAP2K4(1), MAP2K7(2), MAP3K7(3), MAP3K8(2), MAPK10(1), MAPK11(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK8(4), MAPK9(5), MYD88(1), NFKB1(1), NFKB2(1), NFKBIA(2), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), RAC1(1), RELA(2), RIPK1(2), SPP1(1), STAT1(4), TBK1(3), TICAM1(2), TLR2(2), TLR3(2), TLR4(3), TLR5(5), TLR6(2), TLR7(6), TLR8(3), TLR9(2), TOLLIP(1), TRAF6(1) 17303766 159 82 144 46 90 7 23 17 22 0 0.291 1.000 1.000 381 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(1), BRAF(1), CACNA1A(6), GNA13(5), GNAI1(1), GNAI3(2), GNAO1(2), GNAS(4), GNAZ(1), GRIA1(3), GRIA2(3), GRIA3(2), GRID2(2), GRM1(7), GRM5(5), GUCY1A2(4), GUCY1A3(6), GUCY1B3(3), GUCY2C(3), GUCY2D(3), GUCY2F(2), HRAS(6), IGF1R(5), ITPR1(7), ITPR2(9), ITPR3(4), LYN(2), MAP2K1(1), MAPK3(3), NOS1(4), NOS3(6), NRAS(2), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PPP2CA(1), PPP2R1A(1), PPP2R1B(3), PPP2R2B(1), PPP2R2C(1), PRKCA(1), PRKCG(2), PRKG1(1), PRKG2(4), RAF1(1), RYR1(12) 21307832 164 82 161 64 76 6 42 26 14 0 0.854 1.000 1.000 382 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT3(1), CAPN10(1), CAPN11(1), CAPN3(4), CAPN5(3), CAPN6(1), CAPN9(1), CAV2(1), CSK(4), DOCK1(4), FYN(1), ITGA10(1), ITGA11(4), ITGA2(3), ITGA2B(7), ITGA3(4), ITGA4(6), ITGA5(3), ITGA6(2), ITGA7(2), ITGA8(5), ITGA9(3), ITGAD(2), ITGAE(3), ITGAL(2), ITGAM(3), ITGAV(3), ITGB1(1), ITGB2(3), ITGB3(2), ITGB4(5), ITGB5(2), ITGB8(1), MAP2K1(1), MAP2K3(2), MAPK10(1), MAPK12(1), MAPK4(3), MAPK7(2), MYLK2(4), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PDPK1(1), PIK3R2(1), PTK2(3), RAC1(1), RAP1B(2), ROCK1(4), ROCK2(6), SDCCAG8(2), SORBS1(4), SOS1(5), SRC(4), TLN1(2), TNS1(8), VAV2(1), VAV3(2), VCL(1), ZYX(1) 25876391 158 82 158 62 75 3 41 22 17 0 0.929 1.000 1.000 383 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT3(1), CASP9(3), HRAS(6), KDR(9), MAP2K1(1), MAPK11(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPKAPK2(1), NFAT5(7), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), NOS3(6), NRAS(2), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), PLCG1(3), PLCG2(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(2), PRKCA(1), PRKCG(2), PTGS2(2), PTK2(3), RAC1(1), RAF1(1), SH2D2A(3), SHC2(1), SPHK2(4), SRC(4) 13955892 146 81 130 32 77 7 25 20 17 0 0.0294 1.000 1.000 384 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(3), ADCY2(10), ADCY3(2), ADCY4(2), ADCY5(1), ADCY6(4), ADCY7(1), ADCY8(5), ADCY9(3), CACNA1C(5), CACNA1D(5), CACNA1F(4), CACNA1S(5), CALM1(1), CALM2(1), CALML3(1), CALML6(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), EGFR(3), GNAS(4), GNRH1(1), HRAS(6), ITPR1(7), ITPR2(9), ITPR3(4), MAP2K1(1), MAP2K3(2), MAP2K4(1), MAP2K7(2), MAP3K1(3), MAP3K2(2), MAP3K4(5), MAPK10(1), MAPK11(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK7(2), MAPK8(4), MAPK9(5), MMP14(1), MMP2(2), NRAS(2), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PLD1(3), PLD2(1), PRKACB(1), PRKCA(1), PRKCD(1), PRKX(1), PTK2B(3), RAF1(1), SOS1(5), SOS2(4), SRC(4) 24592111 181 81 179 86 78 8 57 20 18 0 0.993 1.000 1.000 385 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1B(1), ACVRL1(3), BMPR1A(1), BMPR2(5), BUB1(8), CDKL1(3), CDKL2(2), CDS1(2), CLK1(3), CLK4(1), COL4A3BP(1), CSNK2A1(4), CSNK2B(2), DGKA(1), DGKB(2), DGKD(3), DGKE(1), DGKG(4), DGKH(2), DGKQ(2), DGKZ(3), IMPA1(1), INPP1(1), INPP4A(1), INPP4B(4), INPP5A(3), INPPL1(2), ITPKA(2), ITPKB(1), MAP3K10(1), MOS(2), NEK3(1), PAK4(1), PIK3C2A(7), PIK3C2B(6), PIK3C2G(3), PIK3CA(26), PIK3CB(5), PIK3CG(3), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PLCD1(1), PLCG1(3), PLCG2(3), PLK3(3), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(1), PRKCD(1), PRKCG(2), PRKCQ(1), PRKCZ(2), PRKD1(2), PRKG1(1), RAF1(1), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), RPS6KA4(1), VRK1(1) 21801298 173 81 156 57 91 9 32 25 16 0 0.699 1.000 1.000 386 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(3), ADCY2(10), ADCY3(2), ADCY4(2), ADCY5(1), ADCY6(4), ADCY7(1), ADCY8(5), ADCY9(3), AKAP1(3), AKAP10(3), AKAP11(8), AKAP12(2), AKAP3(2), AKAP4(1), AKAP5(1), AKAP6(7), AKAP8(1), AKAP9(15), ARHGEF1(6), CALM1(1), CALM2(1), CHMP1B(2), GNA13(5), GNA14(2), GNA15(1), GNAI3(2), GNAL(1), GNAO1(2), GNAZ(1), GNB1(5), GNB3(3), GNB5(2), GNG4(4), HRAS(6), ITPR1(7), KCNJ3(1), NRAS(2), PALM2(1), PDE1A(2), PDE1C(4), PDE4A(1), PDE4B(1), PDE4C(2), PDE4D(2), PDE7A(2), PDE7B(1), PDE8A(1), PLCB3(6), PPP3CA(4), PPP3CC(2), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(1), PRKCD(1), PRKCG(2), PRKCI(1), PRKCQ(1), PRKCZ(2), PRKD1(2), PRKD3(7), RHOA(5), RRAS(1), SLC9A1(1), USP5(1) 22598710 189 80 185 60 95 9 40 27 18 0 0.602 1.000 1.000 387 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(7), AMY2A(2), AMY2B(1), ASCC3(5), ATP13A2(5), DDX18(2), DDX19A(1), DDX23(3), DDX4(3), DDX47(2), DDX50(1), DDX51(1), DDX52(1), DDX54(4), DDX55(2), ENPP1(2), ENTPD7(2), EP400(7), ERCC2(16), ERCC3(2), GAA(2), GANC(3), GBA(2), GBA3(2), GBE1(2), GPI(3), GUSB(1), GYS1(3), GYS2(3), HK1(3), HK2(3), HK3(3), IFIH1(3), MGAM(6), MOV10L1(1), PGM1(2), PYGL(1), PYGM(4), RAD54B(4), RAD54L(1), RUVBL2(1), SETX(5), SI(5), SKIV2L2(2), SMARCA2(9), SMARCA5(1), TREH(1), UGDH(2), UGP2(5), UGT1A1(3), UGT1A3(3), UGT1A5(1), UGT1A6(1), UGT1A9(2), UGT2A1(1), UGT2A3(3), UGT2B10(2), UGT2B28(2), UGT2B4(2), UGT2B7(1) 23807323 173 80 168 59 80 12 40 27 14 0 0.846 1.000 1.000 388 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT3(1), BCL10(1), BLNK(1), BTK(3), CARD11(5), CD19(2), CD22(2), CD79A(1), CD79B(1), CHUK(6), CR2(6), FCGR2B(1), FOS(3), HRAS(6), IKBKB(4), INPP5D(2), LILRB3(2), LYN(2), MALT1(5), NFAT5(7), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), NRAS(2), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PLCG2(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(2), RAC1(1), RASGRP3(2), SYK(1), VAV1(2), VAV2(1), VAV3(2) 14392776 154 79 138 41 76 9 27 20 22 0 0.246 1.000 1.000 389 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT3(1), BCL2L1(2), CDK2(1), CDKN1B(5), CDKN2A(8), CREB5(5), ERBB4(3), GAB1(2), GADD45A(1), GSK3A(1), IFI27(1), INPPL1(2), IRS1(3), IRS2(3), IRS4(8), MET(5), MYC(1), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PAK7(2), PARD3(6), PARD6A(3), PIK3CA(26), PIK3CD(3), PPP1R13B(3), PREX1(3), PTEN(5), PTK2(3), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), SFN(1), SLC2A4(1), SOS1(5), SOS2(4), TSC1(11), TSC2(2), YWHAB(2), YWHAE(2), YWHAQ(1), YWHAZ(3) 14954080 151 76 136 34 77 5 27 9 33 0 0.114 1.000 1.000 390 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(1), APH1A(2), CREBBP(18), CTBP1(1), CTBP2(1), DLL1(4), DLL3(2), DLL4(1), DTX1(5), DTX2(2), DTX3(1), DTX4(1), DVL2(2), DVL3(1), EP300(26), HDAC1(1), HDAC2(1), HES1(4), JAG1(4), LFNG(1), MAML1(1), MAML2(5), MAML3(3), NCOR2(10), NCSTN(6), NOTCH1(5), NOTCH2(5), NOTCH3(3), NOTCH4(4), NUMB(1), PSEN1(5), RBPJ(2), RBPJL(2), SNW1(1) 13412281 132 75 130 39 54 5 33 14 26 0 0.513 1.000 1.000 391 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT3(1), BLNK(1), BTK(3), CD19(2), CD22(2), CR2(6), CSK(4), DAG1(1), GSK3A(1), INPP5D(2), ITPR1(7), ITPR2(9), ITPR3(4), LYN(2), MAP4K1(3), MAPK3(3), NFATC1(4), NFATC2(6), PIK3CA(26), PIK3CD(3), PIK3R1(2), PLCG2(3), PPP1R13B(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PTPRC(5), RAF1(1), SOS1(5), SOS2(4), SYK(1), VAV1(2) 14317456 126 75 111 37 74 10 15 15 12 0 0.329 1.000 1.000 392 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 FN3K(2), IMPA1(1), IMPA2(1), INPP1(1), INPP4A(1), INPP4B(4), INPP5A(3), INPP5B(1), INPPL1(2), ISYNA1(1), ITPK1(1), ITPKA(2), ITPKB(1), MINPP1(1), PI4KB(3), PIK3C3(5), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIP4K2A(2), PIP4K2B(1), PIP4K2C(3), PIP5K1A(5), PIP5K1C(2), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PLCD1(1), PLCD3(1), PLCD4(2), PLCE1(2), PLCG1(3), PLCG2(3), PLCZ1(2), PTEN(5), PTPMT1(1), SYNJ1(3), SYNJ2(2) 14359947 118 73 102 43 74 2 23 12 7 0 0.769 1.000 1.000 393 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(6), BDKRB1(1), C1R(1), C1S(2), C2(1), C3(5), C4BPA(4), C5(3), C8A(2), C8B(2), C9(5), CD46(2), CD55(1), CFB(2), CFH(6), CFI(1), CPB2(3), CR1(3), CR2(6), F10(1), F11(3), F12(1), F13A1(2), F13B(1), F2R(2), F5(9), F8(5), F9(1), FGA(7), FGB(1), FGG(3), KLKB1(1), KNG1(1), MASP1(3), MASP2(3), PLAT(1), PLAU(1), PLAUR(6), PROS1(4), SERPINC1(1), SERPIND1(5), SERPINE1(2), SERPING1(1), THBD(2), VWF(7) 17450494 130 73 130 35 66 6 34 11 13 0 0.256 1.000 1.000 394 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 ASAH1(2), ATF1(1), BRAF(1), CREB5(5), CREBBP(18), DAG1(1), EGR1(1), EGR2(1), EGR3(1), FRS2(3), MAP1B(6), MAP2K4(1), MAP2K7(2), MAPK10(1), MAPK3(3), MAPK8(4), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(3), MAPK9(5), NTRK1(4), PIK3C2G(3), PIK3CA(26), PIK3CD(3), PIK3R1(2), RPS6KA3(2), SRC(4), TERF2IP(2) 9903872 109 73 93 28 59 6 20 11 13 0 0.225 1.000 1.000 395 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CDC40(1), CLK4(1), COL2A1(4), CPSF1(2), CPSF3(2), CPSF4(1), CSTF2(1), CSTF2T(3), CSTF3(1), DDX1(1), DDX20(2), DHX16(3), DHX38(1), DHX8(2), DHX9(6), DICER1(5), FUS(4), LOC440563(3), LSM2(1), METTL3(2), NCBP1(1), NONO(1), NXF1(5), PABPN1(2), PAPOLA(7), PPM1G(3), PRPF18(1), PRPF3(1), PRPF4(3), PRPF4B(1), PRPF8(3), PTBP1(1), PTBP2(4), RBM17(2), RBM5(3), RNGTT(1), RNPS1(1), SF3A1(2), SF3A3(2), SF3B1(8), SF3B2(2), SF3B4(1), SF3B5(1), SF4(2), SFRS14(2), SFRS16(1), SFRS2(3), SFRS6(3), SFRS8(3), SFRS9(3), SNRPB(2), SNRPB2(2), SNRPG(2), SPOP(2), SRPK2(2), SUPT5H(5), U2AF1(1), U2AF2(2), XRN2(3) 20460628 140 72 139 45 73 7 24 12 24 0 0.917 1.000 1.000 396 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(3), AGT(1), CALM1(1), CALM2(1), CAMK4(1), CREBBP(18), CSNK1A1(3), HAND2(1), HRAS(6), MAP2K1(1), MAPK14(1), MAPK3(3), MAPK8(4), MEF2C(2), MYH2(5), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), PIK3CA(26), PIK3R1(2), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), RAF1(1), SYT1(2) 9788646 112 71 95 28 58 7 21 11 15 0 0.197 1.000 1.000 397 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(6), ABCA10(7), ABCA12(6), ABCA13(13), ABCA2(1), ABCA3(1), ABCA4(3), ABCA5(3), ABCA6(4), ABCA7(2), ABCA8(8), ABCA9(7), ABCB1(6), ABCB4(3), ABCB5(3), ABCB6(1), ABCB7(1), ABCB8(2), ABCB9(1), ABCC1(8), ABCC10(2), ABCC11(5), ABCC12(4), ABCC2(2), ABCC3(8), ABCC4(3), ABCC5(3), ABCC6(1), ABCC8(4), ABCC9(7), ABCD1(1), ABCD2(3), ABCD3(7), ABCG1(2), ABCG4(4), ABCG5(2), CFTR(2), TAP1(1), TAP2(1) 22683898 148 70 148 56 83 3 26 15 21 0 0.606 1.000 1.000 398 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 BRAF(1), CHUK(6), DAXX(1), FOS(3), HRAS(6), IKBKB(4), MAP2K1(1), MAP2K3(2), MAP2K4(1), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K12(1), MAP3K13(6), MAP3K14(2), MAP3K2(2), MAP3K4(5), MAP3K5(4), MAP3K6(3), MAP3K7(3), MAP3K8(2), MAP3K9(1), MAP4K1(3), MAP4K2(4), MAP4K3(4), MAP4K4(2), MAP4K5(1), MAPK10(1), MAPK11(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK4(3), MAPK7(2), MAPK8(4), MAPK9(5), MAPKAPK2(1), MEF2A(1), MEF2C(2), MEF2D(1), MKNK1(1), MYC(1), NFKB1(1), NFKBIA(2), PAK2(1), RAC1(1), RAF1(1), RELA(2), RIPK1(2), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), RPS6KA4(1), RPS6KA5(3), SP1(3), STAT1(4), TGFB3(1), TRADD(1), TRAF2(2) 18400061 135 69 134 45 61 5 33 15 21 0 0.726 1.000 1.000 399 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADCY1(3), ADCY2(10), ADCY3(2), ADCY4(2), ADCY5(1), ADCY6(4), ADCY7(1), ADCY8(5), ADK(3), ADSL(1), ADSS(2), ALLC(1), AMPD1(2), AMPD2(1), AMPD3(3), ATIC(1), ATP5A1(1), ATP5B(2), ATP5C1(1), ATP5G1(1), ATP5J(1), DCK(1), ENPP1(2), ENTPD2(1), GART(1), GDA(3), GMPS(2), GUCY1A2(4), GUCY1A3(6), GUCY1B3(3), GUCY2C(3), GUCY2D(3), GUCY2F(2), IMPDH1(1), IMPDH2(2), NT5E(3), PDE1A(2), PDE4A(1), PDE4B(1), PDE4C(2), PDE4D(2), PDE5A(5), PDE6B(1), PDE6C(2), PDE6G(1), PDE7B(1), PDE8A(1), PDE9A(4), PFAS(1), PKLR(1), PKM2(2), POLD1(3), POLD2(3), POLE(6), POLQ(8), POLR1B(1), POLR2B(1), POLR2C(2), POLR2D(1), POLR2E(1), POLR2F(1), POLRMT(2), PPAT(2), PRUNE(4), RRM1(1), RRM2(2) 24748758 150 69 150 66 84 6 34 13 13 0 0.971 1.000 1.000 400 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(3), CD19(2), CD1A(3), CD1B(1), CD1C(2), CD1D(2), CD1E(3), CD2(1), CD22(2), CD33(2), CD34(2), CD36(1), CD38(1), CD3E(1), CD4(1), CD5(1), CD55(1), CD7(2), CD8A(2), CR1(3), CR2(6), CSF1(2), CSF1R(6), CSF2RA(1), CSF3R(2), DNTT(4), EPOR(1), FCGR1A(1), FLT3(3), GP5(1), HLA-DRA(1), HLA-DRB1(1), IL1A(1), IL1B(1), IL2RA(1), IL3RA(3), IL4R(1), IL5RA(2), IL6(2), IL6R(1), IL7(1), IL7R(2), IL9R(1), ITGA1(1), ITGA2(3), ITGA2B(7), ITGA3(4), ITGA4(6), ITGA5(3), ITGA6(2), ITGAM(3), ITGB3(2), KIT(3), KITLG(2), MME(4), MS4A1(3), TFRC(2), THPO(1), TPO(9) 15758645 136 68 136 39 62 6 37 20 11 0 0.286 1.000 1.000 401 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(5), ACSL1(1), ACSL5(1), ACSL6(2), ADIPOR1(2), AGRP(1), AKT3(1), CAMKK2(3), CD36(1), CHUK(6), CPT1A(2), CPT1B(2), CPT1C(2), IKBKB(4), IRS1(3), IRS2(3), IRS4(8), JAK1(3), JAK2(2), JAK3(3), LEPR(4), MAPK10(1), MAPK8(4), MAPK9(5), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), PCK1(3), PPARGC1A(2), PRKAA2(4), PRKAB2(1), PRKAG1(2), PRKCQ(1), RELA(2), RXRA(12), RXRG(5), SLC2A1(3), SLC2A4(1), TNFRSF1B(3), TRADD(1), TRAF2(2), TYK2(2) 16072616 126 68 119 42 59 6 33 12 16 0 0.577 1.000 1.000 402 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR3(1), AKT3(1), ARHGAP1(1), ARHGEF11(3), BTK(3), CFL2(1), GDI1(2), INPPL1(2), ITPR1(7), ITPR2(9), ITPR3(4), LIMK1(2), MYLK(5), MYLK2(4), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PAK7(2), PIK3CA(26), PIK3CD(3), PIK3CG(3), PIK3R1(2), PPP1R13B(3), PTEN(5), RACGAP1(1), ROCK1(4), ROCK2(6), RPS4X(2), WASL(1) 13570348 110 68 95 29 66 4 12 15 13 0 0.246 1.000 1.000 403 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(4), APAF1(1), BAG4(1), BIRC3(1), CASP3(1), CASP6(1), CASP8(4), CASP9(3), CFLAR(1), CHUK(6), DAXX(1), DFFA(4), FADD(1), LMNA(1), LMNB1(2), LMNB2(1), MAP2K7(2), MAP3K1(3), MAP3K14(2), MAP3K5(4), MAPK8(4), NFKB1(1), NFKBIA(2), NUMA1(4), PAK2(1), PRKCD(1), PRKDC(10), PSEN1(5), PTK2(3), RASA1(4), RB1(19), RELA(2), RIPK1(2), SPTAN1(34), TNFRSF1B(3), TRADD(1), TRAF2(2) 13333529 142 67 140 51 70 5 25 7 35 0 0.955 1.000 1.000 404 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(1), ALG1(2), ALG13(1), ALG2(2), ALG6(1), ALG9(1), B3GNT1(1), B3GNT2(2), B3GNT7(1), B4GALT1(1), B4GALT7(1), C1GALT1(1), C1GALT1C1(1), CHPF(2), CHST11(1), CHST12(1), CHST14(1), CHST2(1), CHST4(2), CHST6(1), CHST7(1), CHSY1(2), EXT1(4), EXT2(3), EXTL1(1), EXTL2(2), EXTL3(2), FUT11(2), FUT8(5), GALNT1(1), GALNT11(1), GALNT12(1), GALNT13(1), GALNT2(2), GALNT3(1), GALNT4(1), GALNT5(3), GALNT6(1), GALNT7(1), GALNT8(2), GALNT9(1), GALNTL2(3), GALNTL5(1), GANAB(8), GCNT1(1), GCNT4(1), HS2ST1(1), HS3ST5(1), HS6ST1(1), MAN1A1(3), MAN1A2(2), MAN1B1(5), MAN1C1(4), MAN2A1(5), MGAT1(4), MGAT2(1), MGAT3(1), MGAT4A(2), MGAT5B(1), NDST2(1), NDST3(2), NDST4(2), OGT(2), ST3GAL1(1), ST6GAL1(1), ST6GALNAC1(1), UST(1), WBSCR17(3), XYLT1(3), XYLT2(2) 21218133 127 67 126 56 75 3 17 20 12 0 0.945 1.000 1.000 405 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT3(1), BTK(3), FCER1A(2), FYN(1), GAB2(1), HRAS(6), INPP5D(2), LAT(1), LYN(2), MAP2K1(1), MAP2K3(2), MAP2K4(1), MAP2K7(2), MAPK10(1), MAPK11(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK8(4), MAPK9(5), MS4A2(3), NRAS(2), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), PLCG1(3), PLCG2(3), PRKCA(1), PRKCD(1), RAC1(1), RAF1(1), SOS1(5), SOS2(4), SYK(1), VAV1(2), VAV2(1), VAV3(2) 13929341 121 67 105 39 63 4 22 21 11 0 0.593 1.000 1.000 406 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT3(1), BLNK(1), BTK(3), CD19(2), CSK(4), DAG1(1), EPHB2(3), ITPKA(2), ITPKB(1), LYN(2), MAP2K1(1), NFAT5(7), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), NFKBIL2(2), PIK3CA(26), PIK3CD(3), PIK3R1(2), PLCG2(3), PPP1R13B(3), RAF1(1), SERPINA4(1), SOS1(5), SOS2(4), SYK(1), VAV1(2) 10208077 94 65 79 22 59 3 14 9 9 0 0.138 1.000 1.000 407 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(3), ADAM17(1), ATP6V0A1(6), ATP6V0A2(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V0E1(1), ATP6V1A(3), ATP6V1B1(6), ATP6V1C1(3), ATP6V1E1(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1H(4), CASP3(1), CHUK(6), CSK(4), EGFR(3), F11R(1), GIT1(2), IGSF5(2), IKBKB(4), IL8(1), JAM2(1), JAM3(1), LYN(2), MAP2K4(1), MAP3K14(2), MAPK10(1), MAPK11(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK8(4), MAPK9(5), MET(5), NFKB1(1), NFKB2(1), NFKBIA(2), NOD1(1), PLCG1(3), PLCG2(3), PTPRZ1(7), RAC1(1), RELA(2), SRC(4), TCIRG1(1), TJP1(3) 13600610 115 62 115 29 58 5 30 8 14 0 0.139 1.000 1.000 408 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT3(1), BRD4(2), CAP1(5), CBL(4), CDKN2A(8), GSK3A(1), INPPL1(2), IRS1(3), IRS2(3), IRS4(8), LNPEP(1), MAPK3(3), PARD3(6), PARD6A(3), PIK3CA(26), PIK3CD(3), PIK3R1(2), PTEN(5), RAF1(1), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), SERPINB6(2), SFN(1), SLC2A4(1), SORBS1(4), SOS1(5), SOS2(4), YWHAB(2), YWHAE(2), YWHAQ(1), YWHAZ(3) 11514854 118 62 103 29 68 5 18 9 18 0 0.265 1.000 1.000 409 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(1), ACOX1(1), ACOX2(2), ACOX3(3), ACSL1(1), ACSL5(1), ACSL6(2), ANGPTL4(3), APOA2(1), APOA5(1), AQP7(2), CD36(1), CPT1A(2), CPT1B(2), CPT1C(2), CYP27A1(2), CYP4A11(2), CYP4A22(4), CYP7A1(4), CYP8B1(1), DBI(2), EHHADH(1), FADS2(1), GK2(3), LPL(1), ME1(2), PCK1(3), PDPK1(1), PLTP(1), PPARD(1), PPARG(3), RXRA(12), RXRG(5), SCD(1), SCP2(2), SLC27A1(1), SLC27A2(4), SLC27A4(1), SLC27A5(4), SLC27A6(3), SORBS1(4), UCP1(2) 12654343 96 61 90 27 55 4 21 9 7 0 0.245 1.000 1.000 410 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(1), INPP1(1), INPP4A(1), INPP4B(4), INPP5A(3), INPPL1(2), ITPKA(2), ITPKB(1), PIK3C2A(7), PIK3C2B(6), PIK3C2G(3), PIK3CA(26), PIK3CB(5), PIK3CG(3), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PLCD1(1), PLCG1(3), PLCG2(3) 8640070 85 61 69 27 50 2 14 8 11 0 0.591 1.000 1.000 411 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ALG6(1), CCKBR(3), CCR3(3), CCR5(2), CELSR1(8), CELSR2(5), CELSR3(18), CHRM3(4), CIDEB(1), CXCR3(1), EDNRA(1), EMR2(1), F2R(2), FSHR(1), GHRHR(1), GPR116(2), GPR133(5), GPR135(1), GPR17(3), GPR55(2), GPR56(4), GPR61(4), GPR77(1), GPR84(2), GPR88(3), GRM1(7), HRH4(1), LGR6(3), LPHN2(8), LPHN3(5), LTB4R2(2), NTSR1(1), OR2M4(1), OR8G2(1), P2RY13(2), PTGFR(2), SMO(2), TAAR5(1), TSHR(2) 12862475 117 60 117 58 43 7 37 14 16 0 0.910 1.000 1.000 412 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 APC(7), ASAH1(2), BRAF(1), CCL13(1), CCL15(1), CCL16(1), DAG1(1), EGFR(3), GNA15(1), GNAI1(1), ITPKA(2), ITPKB(1), ITPR1(7), ITPR2(9), ITPR3(4), KCNJ3(1), KCNJ5(1), MAPK10(1), MAPK14(1), PHKA2(1), PIK3CA(26), PIK3CD(3), PIK3R1(2), PTX3(1), RAF1(1), SRC(4) 10319766 84 59 69 23 51 4 11 8 10 0 0.269 1.000 1.000 413 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(3), ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), ALDH3A1(2), ALDH3B1(2), AOC3(1), AOX1(2), CARM1(2), COMT(2), DBH(3), DCT(3), DDC(3), ESCO1(1), ESCO2(1), GSTZ1(1), HPD(2), LCMT2(1), MAOA(1), METTL2B(1), MYST3(5), MYST4(3), PNPLA3(2), PRMT5(3), PRMT6(1), PRMT7(5), PRMT8(4), TPO(9), TYR(3), WBSCR22(3) 11472515 77 58 76 22 35 2 23 13 4 0 0.348 1.000 1.000 414 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR3(1), DAG1(1), DGKA(1), ITGA9(3), ITPKA(2), ITPKB(1), ITPR1(7), ITPR2(9), ITPR3(4), MAP2K1(1), MAPK3(3), NR1I3(2), PDE3A(5), PDE3B(1), PIK3C2G(3), PIK3CA(26), PIK3CD(3), PIK3R1(2), PLDN(2), PSME1(1), RIPK3(1), RPS4X(2), SGCB(1) 9400689 82 58 67 29 54 5 7 8 8 0 0.685 1.000 1.000 415 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(4), CARM1(2), CCND1(1), CREBBP(18), EP300(26), ERCC3(2), GRIP1(1), GTF2A1(1), GTF2E1(1), GTF2F1(1), HDAC1(1), HDAC2(1), HDAC4(2), HDAC5(2), HDAC6(2), MEF2C(2), NCOR2(10), NRIP1(4), PELP1(2) 8892368 83 57 82 22 28 3 23 8 21 0 0.426 1.000 1.000 416 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 CAD(7), CTPS(1), DCK(1), DCTD(1), DPYD(5), DPYS(5), DUT(1), ENTPD3(3), ENTPD5(1), ENTPD6(1), ENTPD8(1), NME4(1), NME7(1), NT5C1A(3), NT5C1B(3), NT5C2(2), NT5C3(2), NT5E(3), PNPT1(3), POLA1(2), POLA2(3), POLD1(3), POLD2(3), POLD3(3), POLE(6), POLE2(1), POLR1A(5), POLR1B(1), POLR1C(1), POLR1D(2), POLR2B(1), POLR2C(2), POLR2D(1), POLR2E(1), POLR2F(1), POLR3A(5), POLR3B(3), POLR3H(1), PRIM2(2), RRM1(1), RRM2(2), TK1(1), TXNRD1(3), TXNRD2(1), TYMS(1), UMPS(1), UPB1(3), UPRT(1) 15663266 106 56 106 36 56 3 19 16 12 0 0.732 1.000 1.000 417 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(6), ATP4A(2), ATP5A1(1), ATP5B(2), ATP5C1(1), ATP5G1(1), ATP5J(1), ATP5O(1), ATP6V0A1(6), ATP6V0A2(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V0E1(1), ATP6V1A(3), ATP6V1B1(6), ATP6V1C1(3), ATP6V1E1(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1H(4), COX10(2), COX15(1), COX5A(1), COX6A1(3), COX6A2(1), COX6C(1), COX7A1(1), COX7B2(1), COX8A(1), CYC1(1), LHPP(2), NDUFA12(1), NDUFA13(2), NDUFA5(1), NDUFA6(1), NDUFA7(1), NDUFA8(1), NDUFB5(1), NDUFB6(1), NDUFB9(3), NDUFS1(2), NDUFS2(1), NDUFS6(1), NDUFV1(2), PPA1(1), SDHA(3), SDHC(2), TCIRG1(1), UQCRB(1), UQCRC2(2), UQCRH(1) 10801393 90 55 88 25 42 7 22 10 9 0 0.253 1.000 1.000 418 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT3(1), BRAF(1), CAB39(1), DDIT4(1), EIF4EBP1(1), FIGF(1), HIF1A(1), MAPK3(3), PDPK1(1), PIK3CA(26), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PRKAA2(4), RHEB(1), RICTOR(4), RPS6(3), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), RPS6KA6(2), TSC1(11), TSC2(2), ULK1(3), ULK2(5), VEGFB(2), VEGFC(1) 10257597 95 55 80 25 51 5 15 9 15 0 0.344 1.000 1.000 419 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 BCL2L1(2), CBL(4), CFLAR(1), E2F1(1), FOS(3), HRAS(6), IL2RA(1), IL2RB(2), IL2RG(3), IRS1(3), JAK1(3), JAK3(3), MAPK3(3), MYC(1), PIK3CA(26), PIK3R1(2), PPIA(1), RAF1(1), SOS1(5), STAT5B(2), SYK(1) 6993674 74 54 58 21 45 4 12 7 6 0 0.369 1.000 1.000 420 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 EIF4A1(1), EIF4A2(3), EIF4E(1), EIF4EBP1(1), EIF4G1(1), EIF4G2(5), EIF4G3(9), MKNK1(1), PDK2(1), PDPK1(1), PIK3CA(26), PIK3R1(2), PPP2CA(1), PTEN(5), RPS6(3), TSC1(11), TSC2(2) 5344593 74 54 59 18 40 4 9 5 16 0 0.500 1.000 1.000 421 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR2(1), ATP8A1(1), AVPR1A(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BRS3(1), CCKBR(3), CCR1(1), CCR10(1), CCR3(3), CCR4(2), CCR5(2), CCR7(3), CCR8(1), CX3CR1(3), CXCR3(1), CXCR4(2), EDNRA(1), EDNRB(2), FPR1(1), FSHR(1), GALR1(1), GALR2(3), GALR3(1), GALT(1), GHSR(1), GPR77(1), LHCGR(2), MC3R(1), MC4R(2), NMBR(3), NPY1R(1), NPY5R(4), NTSR1(1), OPRD1(2), OXTR(1), SSTR1(1), SSTR3(2), SSTR4(3), TACR1(2), TACR3(1), TRHR(2), TSHR(2) 10121851 72 54 72 48 32 0 24 10 6 0 0.994 1.000 1.000 422 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 CABIN1(3), CALM1(1), CALM2(1), HDAC5(2), IGF1R(5), INSR(4), MAPK14(1), MAPK7(2), MEF2A(1), MEF2C(2), MEF2D(1), MYOD1(1), NFATC1(4), NFATC2(6), PIK3CA(26), PIK3R1(2), PPP3CA(4), PPP3CB(4), PPP3CC(2), SYT1(2) 6711350 74 53 59 21 39 5 12 9 9 0 0.352 1.000 1.000 423 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 ABP1(3), ACAT1(1), AFMID(2), ALDH3A1(2), ALDH9A1(2), AOC3(1), AOX1(2), CARM1(2), CAT(3), CYP1A1(1), CYP1A2(2), CYP1B1(2), DDC(3), EHHADH(1), GCDH(2), HAAO(1), HADH(1), HADHA(3), HSD17B10(1), HSD17B4(3), KMO(1), LCMT2(1), LNX1(2), MAOA(1), METTL2B(1), NFX1(3), OGDH(5), OGDHL(4), PRMT5(3), PRMT6(1), PRMT7(5), PRMT8(4), TDO2(1), WBSCR22(3) 11708801 73 53 72 21 40 6 10 11 6 0 0.377 1.000 1.000 424 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(4), AGPAT2(1), AGPAT3(2), CDS1(2), CHAT(2), CHKA(1), CHKB(3), CHPT1(2), DGKA(1), DGKB(2), DGKD(3), DGKE(1), DGKG(4), DGKH(2), DGKI(5), DGKQ(2), DGKZ(3), ESCO1(1), ESCO2(1), ETNK1(1), GPD1(1), GPD1L(1), GPD2(1), LCAT(1), MYST3(5), MYST4(3), PCYT1A(1), PHOSPHO1(1), PISD(2), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), PLD1(3), PLD2(1), PNPLA3(2), PPAP2A(5), PPAP2B(1), PPAP2C(1), PTDSS1(2) 12633261 82 53 82 36 42 4 17 9 10 0 0.959 1.000 1.000 425 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(2), ALPL(1), ASCC3(5), ATP13A2(5), DDX18(2), DDX19A(1), DDX23(3), DDX4(3), DDX47(2), DDX50(1), DDX51(1), DDX52(1), DDX54(4), DDX55(2), ENTPD7(2), EP400(7), ERCC2(16), ERCC3(2), FPGS(1), GCH1(1), IFIH1(3), MOV10L1(1), RAD54B(4), RAD54L(1), RUVBL2(1), SETX(5), SKIV2L2(2), SMARCA2(9), SMARCA5(1) 12109862 89 53 86 32 42 8 19 15 5 0 0.847 1.000 1.000 426 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(7), AXIN1(3), CREBBP(18), CTNNB1(4), EP300(26), HDAC1(1), LDB1(2), LEF1(2), TRRAP(10) 6415918 73 53 72 19 23 3 17 8 22 0 0.455 1.000 1.000 427 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(15), B3GALT4(4), CDR1(2), DGKI(5), FAU(2), IL6ST(3), MRPL19(1), PIGK(3), RPL10(2), RPL11(2), RPL13(1), RPL15(1), RPL23(1), RPL24(2), RPL26(2), RPL28(1), RPL3(1), RPL31(3), RPL35A(1), RPL36(1), RPL37(1), RPL3L(1), RPL4(3), RPL5(1), RPL6(1), RPL7(1), RPLP0(1), RPS13(1), RPS18(4), RPS27A(1), RPS4X(2), RPS6(3), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), RPS6KA6(2), RPS7(1), RPS9(1), SLC36A2(1), TBC1D10C(1), UBA52(1), UBB(2) 10110488 88 53 88 35 46 4 19 10 9 0 0.863 1.000 1.000 428 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(2), EEF1B2(1), EEF1D(1), EEF1G(2), EEF2(1), EEF2K(4), EIF2AK1(2), EIF2AK2(2), EIF2AK3(3), EIF2B1(1), EIF2B2(3), EIF2B4(2), EIF2B5(2), EIF2S3(2), EIF4A1(1), EIF4A2(3), EIF4E(1), EIF4EBP1(1), EIF4EBP2(1), EIF4G1(1), EIF4G3(9), EIF5A(1), EIF5B(6), ETF1(2), KIAA0664(4), PABPC3(3), PAIP1(7), SLC35A4(1) 8446237 69 53 68 22 35 2 12 9 11 0 0.833 1.000 1.000 429 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), AKR1C4(1), ALDH3A1(2), ALDH3B1(2), CYP1A1(1), CYP1A2(2), CYP1B1(2), CYP2B6(2), CYP2C18(1), CYP2C19(1), CYP2C9(2), CYP2E1(1), CYP2F1(2), CYP3A4(5), CYP3A43(1), CYP3A7(6), DHDH(3), GSTA1(1), GSTA2(1), GSTA4(1), GSTA5(2), GSTM2(1), GSTM3(1), GSTM5(2), GSTP1(2), GSTZ1(1), UGT1A1(3), UGT1A3(3), UGT1A5(1), UGT1A6(1), UGT1A9(2), UGT2A1(1), UGT2A3(3), UGT2B10(2), UGT2B28(2), UGT2B4(2), UGT2B7(1) 11033323 75 52 75 30 38 6 15 7 9 0 0.776 1.000 1.000 430 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(7), AMY2A(2), AMY2B(1), ENPP1(2), GAA(2), GANAB(8), GBA3(2), GBE1(2), GPI(3), GUSB(1), GYS1(3), GYS2(3), HK1(3), HK2(3), HK3(3), MGAM(6), PGM1(2), PYGL(1), PYGM(4), SI(5), UCHL1(1), UGDH(2), UGT1A1(3), UGT1A3(3), UGT1A5(1), UGT1A6(1), UGT1A9(2), UGT2B4(2) 10951877 78 52 77 32 36 4 21 7 10 0 0.924 1.000 1.000 431 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(1), CPEB1(3), EGFR(3), ERBB2(11), ERBB4(3), ETS1(2), ETV6(4), ETV7(1), FMN2(7), MAP2K1(1), MAPK3(3), NOTCH1(5), NOTCH2(5), NOTCH3(3), NOTCH4(4), PIWIL1(4), PIWIL3(3), PIWIL4(4), RAF1(1), SOS1(5), SOS2(4), SPIRE2(3) 10112030 80 51 79 24 39 0 23 9 9 0 0.588 1.000 1.000 432 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ACCN1(2), ADCY4(2), ADCY6(4), ADCY8(5), CACNA1A(6), CACNA1B(2), GNAS(4), GNB1(5), GNB3(3), GRM4(1), ITPR3(4), KCNB1(3), PDE1A(2), PLCB2(1), PRKACB(1), PRKX(1), SCNN1A(4), SCNN1B(1), SCNN1G(1), TAS1R1(2), TAS1R3(5), TAS2R1(1), TAS2R13(1), TAS2R16(1), TAS2R39(1), TAS2R40(2), TAS2R43(1), TAS2R50(3), TAS2R60(1), TAS2R9(3), TRPM5(4) 10962344 77 51 75 35 40 5 19 8 5 0 0.709 1.000 1.000 433 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(1), ESRRA(2), HNF4A(1), NR1D1(3), NR1D2(3), NR1H2(4), NR1I2(1), NR1I3(2), NR2C2(2), NR2F1(2), NR2F2(2), NR3C1(1), NR4A1(1), NR4A2(2), PGR(1), PPARD(1), PPARG(3), RARA(3), RARB(4), RARG(11), ROR1(2), RORA(1), RORC(2), RXRA(12), RXRG(5), VDR(1) 8105847 73 51 67 24 36 4 13 8 12 0 0.510 1.000 1.000 434 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT3(1), GSK3A(1), IL4R(1), IRS1(3), IRS2(3), JAK1(3), JAK3(3), MAP4K1(3), MAPK3(3), PIK3CA(26), PIK3CD(3), PIK3R1(2), PPP1R13B(3), RAF1(1), SOS1(5), SOS2(4), STAT6(3) 7102277 68 51 53 18 44 2 7 9 6 0 0.352 1.000 1.000 435 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(7), AXIN1(3), CCND1(1), CCND3(5), CSNK1E(1), CTNNB1(4), DVL2(2), DVL3(1), FOSL1(1), FZD10(1), FZD3(3), FZD6(4), FZD7(2), FZD8(1), FZD9(2), LDLR(2), MAPK10(1), MAPK9(5), MYC(1), PAFAH1B1(1), PLAU(1), PPP2R5E(2), PRKCA(1), PRKCD(1), PRKCG(2), PRKCI(1), PRKCQ(1), PRKCZ(2), PRKD1(2), RAC1(1), RHOA(5), SFRP4(2), WNT2(2), WNT5A(1), WNT6(1), WNT7A(2), WNT7B(1) 11623560 76 51 76 33 34 5 18 7 12 0 0.937 1.000 1.000 436 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP3(1), CASP6(1), CASP8(4), CFLAR(1), DAXX(1), DFFA(4), FADD(1), FAF1(1), LMNA(1), LMNB1(2), LMNB2(1), MAP2K4(1), MAP3K1(3), MAP3K7(3), MAPK8(4), PAK2(1), PRKDC(10), PTPN13(7), RB1(19), RIPK2(1), SPTAN1(34) 7809634 101 50 99 33 49 5 12 5 30 0 0.931 1.000 1.000 437 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASS(3), ACAT1(1), AKR1B10(1), ALDH3A1(2), ALDH9A1(2), BBOX1(1), DLST(1), DOT1L(9), EHHADH(1), EHMT1(2), EHMT2(4), GCDH(2), HADH(1), HADHA(3), HSD17B10(1), HSD17B4(3), HSD3B7(1), NSD1(7), OGDH(5), OGDHL(4), PIPOX(2), PLOD1(1), PLOD2(3), RDH13(1), SETD1A(3), SETDB1(4), SHMT1(1), TMLHE(1) 11209014 70 50 70 42 41 2 10 8 9 0 0.999 1.000 1.000 438 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), AGPAT2(1), AGPAT3(2), AKR1B1(1), ALDH3A1(2), ALDH9A1(2), CEL(2), DAK(1), DGAT1(1), DGKA(1), DGKB(2), DGKD(3), DGKE(1), DGKG(4), DGKH(2), DGKI(5), DGKQ(2), DGKZ(3), GK2(3), GLA(1), GLB1(2), LCT(4), LIPA(1), LIPC(5), LIPG(2), LPL(1), MGLL(1), PNLIP(3), PNLIPRP1(4), PNPLA3(2), PPAP2A(5), PPAP2B(1), PPAP2C(1) 11310718 79 50 79 30 46 3 14 7 9 0 0.646 1.000 1.000 439 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP4(1), BMP5(1), BMP6(1), BMP8B(1), CSNK1A1(3), CSNK1A1L(1), CSNK1E(1), CSNK1G1(3), CSNK1G2(1), CSNK1G3(1), FBXW11(1), GLI1(4), GLI2(4), GLI3(10), HHIP(4), IHH(2), LRP2(12), PRKACB(1), PRKX(1), PTCH1(8), PTCH2(1), RAB23(1), SMO(2), STK36(5), WNT2(2), WNT3A(1), WNT5A(1), WNT6(1), WNT7A(2), WNT7B(1), WNT8A(1), ZIC2(3) 11716731 82 50 82 34 31 3 31 5 12 0 0.891 1.000 1.000 440 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT3(1), ARHGEF11(3), DLG4(3), GNA13(5), LPA(7), MAP2K4(1), MAP3K1(3), MAP3K5(4), MAPK8(4), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), NFKBIL2(2), PHKA2(1), PIK3CB(5), PLD1(3), PLD2(1), PLD3(3), PTK2(3), RDX(2), ROCK1(4), ROCK2(6), SERPINA4(1) 9477595 75 50 74 24 38 2 15 7 13 0 0.751 1.000 1.000 441 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 EIF4A1(1), EIF4A2(3), EIF4E(1), EIF4EBP1(1), EIF4G1(1), EIF4G2(5), EIF4G3(9), GHR(2), IRS1(3), MAPK14(1), MAPK3(3), MKNK1(1), PDK2(1), PDPK1(1), PIK3CA(26), PIK3R1(2), PRKCA(1), PTEN(5) 5453102 67 49 52 22 41 4 6 7 9 0 0.893 1.000 1.000 442 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 CHUK(6), DAXX(1), EGF(4), EGFR(3), ETS1(2), FOS(3), HRAS(6), IKBKB(4), MAP2K1(1), MAP2K3(2), MAP2K4(1), MAP2K7(2), MAP3K1(3), MAP3K14(2), MAP3K5(4), MAPK13(1), MAPK14(1), MAPK3(3), MAPK8(4), NFKB1(1), NFKBIA(2), PPP2CA(1), PRKCA(1), PRKCD(1), PRKCG(2), PRKCQ(1), RAF1(1), RELA(2), RIPK1(2), SP1(3), TNFRSF1B(3), TRAF2(2) 9497857 75 49 74 32 31 4 23 8 9 0 0.921 1.000 1.000 443 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(3), CALM1(1), CALM2(1), CHRM1(1), FLT1(1), FLT4(1), KDR(9), NOS3(6), PDE2A(1), PDE3A(5), PDE3B(1), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKG1(1), PRKG2(4), RYR2(21), SLC7A1(4), SYT1(2), TNNI1(2) 7781154 71 49 71 31 34 2 18 7 10 0 0.923 1.000 1.000 444 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 BAG4(1), CASP3(1), CASP8(4), DFFA(4), FADD(1), LMNA(1), LMNB1(2), LMNB2(1), MADD(1), MAP2K4(1), MAP3K1(3), MAP3K7(3), MAPK8(4), PAK2(1), PRKDC(10), RB1(19), RIPK1(2), SPTAN1(34), TRADD(1), TRAF2(2) 7466731 96 49 94 28 45 5 11 7 28 0 0.738 1.000 1.000 445 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ABP1(3), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2), AOC3(1), AOX1(2), CAT(3), CYP1A1(1), CYP1A2(2), CYP2A13(3), CYP2A6(3), CYP2A7(3), CYP2B6(2), CYP2C18(1), CYP2C19(1), CYP2C9(2), CYP2D6(1), CYP2E1(1), CYP2F1(2), CYP3A4(5), CYP3A7(6), CYP4B1(3), CYP51A1(2), DDC(3), EHHADH(1), GCDH(2), HAAO(1), HADHA(3), KMO(1), MAOA(1), SDS(1), TDO2(1) 10636058 69 49 69 31 38 1 12 10 8 0 0.888 1.000 1.000 446 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT3(1), ASAH1(2), BRAF(1), DAG1(1), EGFR(3), EPHB2(3), ITPKA(2), ITPKB(1), ITPR1(7), ITPR2(9), ITPR3(4), KCNJ3(1), KCNJ5(1), PIK3CB(5), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), RAF1(1), SOS1(5), SOS2(4), SRC(4), TERF2IP(2) 11325403 70 47 69 32 37 3 16 7 7 0 0.945 1.000 1.000 447 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT3(1), CISH(1), IL13RA1(1), IL2RG(3), IL4R(1), INPP5D(2), JAK1(3), JAK2(2), JAK3(3), PIK3CA(26), PPP1R13B(3), SERPINA4(1), SOS1(5), SOS2(4), SRC(4), STAT6(3), TYK2(2) 7135316 65 47 50 22 49 2 7 6 1 0 0.657 1.000 1.000 448 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(1), BIRC3(1), CASP3(1), CASP6(1), CASP8(4), CASP9(3), CFLAR(1), CHUK(6), DFFA(4), FADD(1), GAS2(2), LMNA(1), MAP3K14(2), NFKB1(1), NFKBIA(2), RELA(2), RIPK1(2), SPTAN1(34), TNFRSF10A(4), TNFRSF25(3), TNFSF10(2), TRADD(1), TRAF2(2) 6462866 81 46 81 22 47 1 14 3 16 0 0.505 1.000 1.000 449 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(4), ACTR3(1), CFL2(1), FLNA(5), FLNC(5), FSCN1(1), FSCN2(2), GDI1(2), LIMK1(2), MYH2(5), MYLK(5), MYLK2(4), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PAK7(2), PFN1(2), ROCK1(4), ROCK2(6), RPS4X(2), WASL(1) 9282557 61 46 61 23 30 0 13 9 9 0 0.771 1.000 1.000 450 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(7), AXIN1(3), CCND1(1), CREBBP(18), CSNK1A1(3), CSNK2A1(4), CTBP1(1), CTNNB1(4), HDAC1(1), MAP3K7(3), MYC(1), NLK(2), PPARD(1), PPP2CA(1), TLE1(4), WIF1(2) 5669390 56 46 55 18 21 2 13 4 16 0 0.785 1.000 1.000 451 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(1), BAX(1), BCL2L1(2), CASP1(2), CASP3(1), CASP4(2), CASP6(1), CASP8(4), CASP9(3), CD40(1), DAXX(1), DFFA(4), FADD(1), IKBKE(2), MCL1(1), NFKB1(1), NFKBIA(2), NGFR(3), NR3C1(1), NTRK1(4), PTPN13(7), RIPK1(2), SFRS2IP(2), TFG(4), TNFRSF1B(3), TRADD(1), TRAF2(2), TRAF6(1) 8380146 60 45 60 26 30 0 15 4 11 0 0.958 1.000 1.000 452 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), AGPAT2(1), AGPAT3(2), AKR1B1(1), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2), CEL(2), DGAT1(1), DGKA(1), DGKB(2), DGKD(3), DGKE(1), DGKG(4), DGKH(2), DGKQ(2), DGKZ(3), GLA(1), GLB1(2), LCT(4), LIPC(5), LIPG(2), LPL(1), PNLIP(3), PNLIPRP1(4), PPAP2A(5), PPAP2B(1), PPAP2C(1) 9288337 69 45 69 31 40 2 11 7 9 0 0.876 1.000 1.000 453 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(4), AGPAT2(1), AGPAT3(2), AGPS(2), CDS1(2), CHAT(2), CHKA(1), CHKB(3), CPT1B(2), DGKA(1), DGKB(2), DGKD(3), DGKE(1), DGKG(4), DGKH(2), DGKQ(2), DGKZ(3), ETNK1(1), GPD1(1), GPD2(1), LCAT(1), LGALS13(2), PAFAH1B1(1), PAFAH2(1), PCYT1A(1), PISD(2), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), PLCB2(1), PLCG1(3), PLCG2(3), PPAP2A(5), PPAP2B(1), PPAP2C(1) 9642734 70 45 70 31 38 3 14 7 8 0 0.886 1.000 1.000 454 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 ABO(1), B3GALT4(4), B3GALT5(1), B3GNT1(1), B3GNT2(2), B3GNT4(1), B3GNT5(6), B4GALT1(1), B4GALT6(2), FUT1(2), FUT2(1), FUT3(1), FUT5(1), FUT9(1), GCNT2(1), PIGB(3), PIGC(1), PIGF(2), PIGG(6), PIGK(3), PIGL(1), PIGM(1), PIGN(1), PIGO(2), PIGS(2), PIGT(1), PIGU(1), PIGV(1), PIGZ(1), ST3GAL1(1), ST3GAL5(2), ST3GAL6(2), ST6GALNAC3(2), ST6GALNAC4(1), ST6GALNAC5(3), ST6GALNAC6(1), ST8SIA1(1), UGCG(1) 9353394 66 45 66 21 35 2 15 9 5 0 0.282 1.000 1.000 455 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(19), BMPR1B(2), CDK4(2), CDKN1B(5), CEBPB(3), DAZL(1), DMC1(1), EGR1(1), FSHR(1), INHA(1), LHCGR(2), MLH1(4), MSH5(3), NCOR1(13), NRIP1(4), PGR(1), PRLR(1), PTGER2(1), SMPD1(3), VDR(1) 6741023 69 45 69 24 31 2 12 8 16 0 0.851 1.000 1.000 456 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 APC(7), AXIN1(3), CCND1(1), CTNNB1(4), GJA1(1), GNAI1(1), LEF1(2), LY96(1), MYD88(1), NFKB1(1), PDPK1(1), PIK3CA(26), PIK3R1(2), PPP2CA(1), RELA(2), TLR4(3), TOLLIP(1) 5945217 58 44 43 15 34 3 9 3 9 0 0.497 1.000 1.000 457 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(1), AKR1D1(2), ARSD(2), CARM1(2), CYP11B2(3), HSD17B1(1), HSD17B3(1), HSD17B8(3), HSD3B1(2), HSD3B2(3), LCMT2(1), METTL2B(1), PRMT5(3), PRMT6(1), PRMT7(5), PRMT8(4), SRD5A1(1), SRD5A2(1), STS(2), SULT2A1(1), SULT2B1(1), UGT1A1(3), UGT1A3(3), UGT1A5(1), UGT1A6(1), UGT1A9(2), UGT2A1(1), UGT2A3(3), UGT2B10(2), UGT2B28(2), UGT2B4(2), UGT2B7(1), WBSCR22(3) 9664217 65 44 64 20 32 5 14 12 2 0 0.433 1.000 1.000 458 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(1), CANX(1), CD4(1), CD8A(2), CIITA(2), CTSB(1), CTSL1(1), CTSS(1), HLA-A(5), HLA-C(2), HLA-DMB(1), HLA-DQA1(1), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(1), HLA-DRB1(1), HLA-E(1), HLA-F(1), HSP90AA1(8), HSP90AB1(4), HSPA5(1), IFNA16(1), IFNA4(3), KIR2DL1(1), KIR2DL3(1), KIR3DL1(2), KLRC4(2), KLRD1(1), NFYA(1), PDIA3(3), PSME1(1), RFX5(1), RFXANK(1), TAP1(1), TAP2(1), TAPBP(1) 8924652 60 44 59 27 27 2 11 6 14 0 0.929 1.000 1.000 459 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(3), COL4A2(5), COL4A3(5), COL4A4(4), COL4A5(2), COL4A6(1), F10(1), F11(3), F12(1), F2R(2), F5(9), F8(5), F9(1), FGA(7), FGB(1), FGG(3), KLKB1(1), PROS1(4), SERPINC1(1), SERPING1(1) 8526258 60 44 59 21 33 1 19 2 5 0 0.936 1.000 1.000 460 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(1), AKR1B10(1), ALDOA(2), FBP1(1), FPGT(5), FUK(2), GMDS(3), GMPPA(1), GMPPB(2), HK1(3), HK2(3), HK3(3), HSD3B7(1), LHPP(2), MPI(2), MTMR1(2), MTMR2(3), MTMR6(4), PFKFB1(2), PFKFB2(2), PFKFB3(3), PFKP(1), PGM2(1), PMM1(3), PMM2(1), RDH13(1), TSTA3(1) 7200946 56 43 56 24 37 1 7 3 8 0 0.757 1.000 1.000 461 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(6), ATP5O(1), ATP6V0A1(6), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(6), ATP6V1C1(3), ATP6V1E1(1), ATP6V1G2(1), ATP6V1H(4), ATP7A(2), ATP7B(1), COX10(2), COX5A(1), COX6A1(3), COX6A2(1), COX6C(1), COX7A1(1), COX8A(1), NDUFA5(1), NDUFA8(1), NDUFB5(1), NDUFB6(1), NDUFS1(2), NDUFS2(1), NDUFV1(2), SDHA(3), SHMT1(1), UQCRB(1), UQCRH(1) 7385928 63 43 61 16 31 4 16 7 5 0 0.217 1.000 1.000 462 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(1), AGTR2(1), CALM1(1), CALM2(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), CDK5(1), FYN(1), GNAI1(1), GNB1(5), HRAS(6), JAK2(2), MAP2K1(1), MAPK14(1), MAPK3(3), MAPK8(4), MAPT(5), MYLK(5), PLCG1(3), PRKCA(1), PTK2B(3), RAF1(1), SOS1(5), STAT1(4), SYT1(2) 8045102 64 42 63 18 34 2 11 10 7 0 0.390 1.000 1.000 463 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(1), F11(3), F12(1), F13B(1), F5(9), F8(5), F9(1), FGA(7), FGB(1), FGG(3), LPA(7), PLAT(1), PLAU(1), SERPINB2(1), SERPINE1(2), VWF(7) 6796099 51 42 51 15 28 1 16 2 4 0 0.524 1.000 1.000 464 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 CEBPB(3), CLDN5(1), CLOCK(1), CRY1(1), CRY2(3), DAZAP2(2), DNAJA1(1), EIF4G2(5), ETV6(4), GFRA1(2), GSTM3(1), GSTP1(2), HERPUD1(1), HSPA8(2), NCKAP1(5), NCOA4(2), NR1D2(3), PER1(3), PER2(1), PIGF(2), PPP1R3C(1), PURA(1), SF3A3(2), TOB1(4), TUBB3(5), UGP2(5), VAPA(2), ZFR(1) 7043852 66 42 65 17 36 3 13 4 10 0 0.542 1.000 1.000 465 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(13), ACACB(5), ACAT1(1), ACSS1(1), AKR1B1(1), ALDH3A1(2), ALDH9A1(2), DLAT(1), DLD(2), GLO1(1), GRHPR(1), HAGH(1), LDHAL6A(1), LDHAL6B(1), LDHD(2), MDH1(1), ME1(2), ME2(1), ME3(1), PC(2), PCK1(3), PDHA2(2), PKLR(1), PKM2(2) 9052196 50 42 49 21 27 0 10 3 10 0 0.871 1.000 1.000 466 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR3(1), ARHGAP1(1), ARHGAP5(8), ARHGAP6(4), ARHGEF1(6), ARHGEF11(3), ARHGEF5(2), ARPC2(3), ARPC4(1), DIAPH1(2), LIMK1(2), MYL2(2), MYLK(5), PFN1(2), PIP5K1A(5), PPP1R12B(2), ROCK1(4), SRC(4), TLN1(2), VCL(1) 8757657 60 42 60 15 37 0 11 5 7 0 0.285 1.000 1.000 467 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(1), APC(7), ASAH1(2), DAG1(1), DLG4(3), EPHB2(3), GNAI1(1), ITPR1(7), ITPR2(9), ITPR3(4), KCNJ3(1), KCNJ5(1), PTX3(1), RAC1(1), RYR1(12) 8882824 54 42 54 21 27 3 8 6 10 0 0.729 1.000 1.000 468 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(5), CDC7(1), CDK2(1), CDT1(2), DIAPH2(4), MCM10(1), MCM2(1), MCM3(1), MCM4(4), MCM6(2), NACA(1), ORC1L(1), ORC3L(3), PCNA(1), POLA2(3), POLD1(3), POLD2(3), POLD3(3), POLE(6), POLE2(1), RFC1(3), RFC4(4), RPA3(3), RPS27A(1), UBA52(1), UBB(2) 9800033 61 41 61 21 36 0 12 6 7 0 0.703 1.000 1.000 469 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 AK3L1(1), CAD(7), CTPS(1), DCK(1), DCTD(1), DPYD(5), DPYS(5), DUT(1), NT5E(3), POLD1(3), POLD2(3), POLE(6), POLQ(8), POLR1B(1), POLR2B(1), POLR2C(2), POLR2D(1), POLR2E(1), POLR2F(1), POLRMT(2), RRM1(1), RRM2(2), TK1(1), TXNRD1(3), TYMS(1), UMPS(1), UPB1(3) 11097581 66 41 66 22 41 0 8 11 6 0 0.568 1.000 1.000 470 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CHUK(6), FOS(3), IKBKB(4), LY96(1), MAP2K3(2), MAP2K4(1), MAP3K1(3), MAP3K14(2), MAP3K7(3), MAPK14(1), MAPK8(4), MYD88(1), NFKB1(1), NFKBIA(2), RELA(2), TLR10(4), TLR2(2), TLR3(2), TLR4(3), TLR6(2), TLR7(6), TLR9(2), TOLLIP(1), TRAF6(1) 7040216 59 41 59 18 28 2 11 5 13 0 0.602 1.000 1.000 471 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(1), CARS2(3), DARS(2), DARS2(3), EARS2(1), EPRS(5), FARSA(1), FARSB(2), GARS(1), IARS2(2), KARS(3), LARS(1), LARS2(1), MTFMT(1), NARS(1), NARS2(2), QARS(3), RARS(1), RARS2(2), SARS(2), SARS2(2), TARS2(8), VARS(3), VARS2(4), YARS(3), YARS2(1) 10493955 59 40 58 19 37 4 12 3 3 0 0.581 1.000 1.000 472 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(2), POLA2(3), POLD1(3), POLD2(3), POLD3(3), POLE(6), POLE2(1), POLG2(3), POLH(2), POLI(2), POLK(6), POLM(2), POLQ(8), PRIM2(2), REV1(2), REV3L(10) 7805948 58 39 58 16 33 1 8 6 10 0 0.635 1.000 1.000 473 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(4), ADCY3(2), ADCY9(3), ARF3(1), ATP6V0A1(6), ATP6V0A2(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V0E1(1), ATP6V1A(3), ATP6V1C1(3), ATP6V1E1(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1H(4), GNAS(4), PDIA4(1), PLCG1(3), PLCG2(3), PRKCA(1), SEC61A2(1), TRIM23(2) 7154229 50 39 50 17 26 3 8 6 7 0 0.544 1.000 1.000 474 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(13), ACAT1(1), AKR1B1(1), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2), DLAT(1), DLD(2), GLO1(1), GRHPR(1), HAGH(1), LDHD(2), MDH1(1), ME1(2), ME2(1), ME3(1), PC(2), PCK1(3), PDHA2(2), PKLR(1), PKM2(2) 7144639 45 39 45 21 25 0 9 2 9 0 0.947 1.000 1.000 475 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(4), EGF(4), EGFR(3), HRAS(6), MAP2K1(1), MAPK3(3), PTPRB(5), RAF1(1), RASA1(4), SOS1(5), SPRY1(1), SPRY4(2), SRC(4) 4817454 43 38 42 11 23 1 14 3 2 0 0.407 1.000 1.000 476 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 APC(7), AXIN1(3), BMP4(1), BMP5(1), BMPR1A(1), BMPR2(5), CHRD(5), CTNNB1(4), MAP3K7(3), MEF2C(2), MYL2(2), NOG(1), NPPB(1), RFC1(3), TGFB3(1), TGFBR2(3), TGFBR3(7) 7033970 50 37 50 17 29 0 8 4 9 0 0.823 1.000 1.000 477 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH3B1(2), ALDH9A1(2), ALDOA(2), DLAT(1), DLD(2), ENO1(2), ENO2(1), ENO3(1), FBP1(1), GPI(3), HK1(3), HK2(3), HK3(3), PDHA2(2), PFKP(1), PGAM1(1), PGM1(2), PKLR(1), PKM2(2) 9450979 48 37 48 32 27 0 11 3 7 0 0.997 1.000 1.000 478 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH3B1(2), ALDH9A1(2), ALDOA(2), DLAT(1), DLD(2), ENO1(2), ENO2(1), ENO3(1), FBP1(1), GPI(3), HK1(3), HK2(3), HK3(3), PDHA2(2), PFKP(1), PGAM1(1), PGM1(2), PKLR(1), PKM2(2) 9450979 48 37 48 32 27 0 11 3 7 0 0.997 1.000 1.000 479 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(1), ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), ALDH3A1(2), ALDH3B1(2), ALDH9A1(2), ALDOA(2), DLAT(1), DLD(2), ENO1(2), ENO2(1), ENO3(1), FBP1(1), GALM(2), GAPDHS(1), GPI(3), HK1(3), HK2(3), HK3(3), LDHAL6A(1), LDHAL6B(1), PDHA2(2), PFKP(1), PGAM1(1), PGM1(2), PKLR(1), PKM2(2) 11262038 51 37 51 39 29 0 12 2 8 0 1.000 1.000 1.000 480 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(3), AKR1B10(1), ALAS1(5), AMT(1), AOC3(1), CHKA(1), CHKB(3), CTH(2), DLD(2), DMGDH(2), GARS(1), GATM(1), GLDC(4), HSD3B7(1), MAOA(1), PIPOX(2), PISD(2), PSAT1(1), PSPH(3), RDH13(1), SARS(2), SARS2(2), SDS(1), SHMT1(1), TARS2(8) 8242557 52 37 52 21 27 3 11 4 7 0 0.757 1.000 1.000 481 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 ALOX12B(2), ALOX15(2), ALOX5(2), CYP2B6(2), CYP2C18(1), CYP2C19(1), CYP2C9(2), CYP2E1(1), CYP2U1(1), CYP4A11(2), CYP4A22(4), CYP4F2(4), CYP4F3(2), EPHX2(2), GGT1(1), GPX3(2), GPX6(2), LTA4H(1), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), PTGES2(2), PTGIS(1), PTGS2(2), TBXAS1(3) 7513504 50 37 50 20 26 1 12 4 7 0 0.620 1.000 1.000 482 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(3), ACTN1(2), ACTN2(3), ACTN3(2), CAPNS2(1), CSK(4), FYN(1), HRAS(6), ITGA1(1), ITGB1(1), MAP2K1(1), MAPK3(3), MAPK8(4), PPP1R12B(2), PTK2(3), RAF1(1), RAP1A(1), ROCK1(4), SOS1(5), SRC(4), TLN1(2), VCL(1), ZYX(1) 9121297 56 37 55 20 35 3 11 4 3 0 0.724 1.000 1.000 483 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2B(2), CAMK2D(1), CAMK2G(3), DAG1(1), ITPKA(2), ITPKB(1), ITPR1(7), ITPR2(9), ITPR3(4), NFAT5(7), PDE6A(1), PDE6B(1), PDE6C(2), PDE6G(1), PDE6H(1), SLC6A13(1) 6918933 44 37 44 16 24 3 8 3 6 0 0.685 1.000 1.000 484 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ADC(1), ALDH4A1(1), CAD(7), CPS1(4), EARS2(1), EPRS(5), GAD1(5), GCLC(1), GCLM(1), GFPT1(1), GFPT2(1), GLS(1), GLS2(1), GLUD1(2), GLUD2(3), GMPS(2), GNPNAT1(1), GSR(2), GSS(1), NADSYN1(3), NAGK(2), PPAT(2), QARS(3) 7640218 51 36 51 24 28 1 12 4 6 0 0.941 1.000 1.000 485 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(1), ACY3(3), ADSL(1), ADSS(2), ASL(3), ASPA(2), ASRGL1(1), ASS1(2), CAD(7), CRAT(5), DARS(2), DARS2(3), DLAT(1), DLD(2), GAD1(5), NARS(1), NARS2(2), PC(2), PDHA2(2) 7322026 47 36 47 19 26 1 11 5 4 0 0.792 1.000 1.000 486 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(1), ALAS1(5), BLVRA(1), COX10(2), COX15(1), CP(1), EARS2(1), EPRS(5), FECH(1), FTH1(3), GUSB(1), HCCS(1), HMOX2(1), MMAB(1), PPOX(4), UGT1A1(3), UGT1A3(3), UGT1A5(1), UGT1A6(1), UGT1A9(2), UGT2A1(1), UGT2A3(3), UGT2B10(2), UGT2B28(2), UGT2B4(2), UGT2B7(1), UROD(1), UROS(2) 8101375 53 36 53 15 25 2 10 6 10 0 0.484 1.000 1.000 487 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 BLNK(1), FOS(3), HRAS(6), LYN(2), MAP2K1(1), MAP3K1(3), MAPK3(3), MAPK8IP3(3), PAPPA(4), RAC1(1), RPS6KA1(1), RPS6KA3(2), SOS1(5), SYK(1), VAV1(2), VAV2(1), VAV3(2) 6185886 41 36 40 14 20 0 14 5 2 0 0.665 1.000 1.000 488 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(1), AKT3(1), DAG1(1), ITPKA(2), ITPKB(1), ITPR1(7), ITPR2(9), ITPR3(4), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), NFKBIL2(2), PHKA2(1), PIK3CB(5), PLD1(3), PLD2(1), PLD3(3) 8687058 54 36 54 25 30 2 11 2 9 0 0.928 1.000 1.000 489 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(3), ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), ALDH3A1(2), ALDH3B1(2), AOC3(1), AOX1(2), COMT(2), DBH(3), DCT(3), DDC(3), GSTZ1(1), HPD(2), MAOA(1), TPO(9), TYR(3) 6114589 45 36 45 15 18 0 18 6 3 0 0.466 1.000 1.000 490 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(1), CALM1(1), CALM2(1), EGFR(3), HRAS(6), MAP2K1(1), MAP2K4(1), MAP3K1(3), MAPK3(3), MAPK8(4), MEF2A(1), MEF2C(2), MEF2D(1), PRKCA(1), PTK2(3), PTK2B(3), RAC1(1), RAF1(1), SOS1(5), SRC(4), SYT1(2) 6461198 48 35 47 15 23 1 16 6 2 0 0.626 1.000 1.000 491 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP5(3), ACPP(5), ACPT(3), ALPI(2), ALPL(1), CYP1A1(1), CYP1A2(2), CYP2A13(3), CYP2A6(3), CYP2A7(3), CYP2B6(2), CYP2C18(1), CYP2C19(1), CYP2C9(2), CYP2D6(1), CYP2E1(1), CYP2F1(2), CYP3A4(5), CYP3A7(6), CYP4B1(3), CYP51A1(2), PON1(1) 5656467 53 35 52 26 31 2 8 5 7 0 0.863 1.000 1.000 492 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(1), ACAA2(1), ACAD8(1), ACAD9(1), ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), AKR1B10(1), AKR1C4(1), AKR1D1(2), ALDH3A1(2), ALDH9A1(2), BAAT(1), CEL(2), CYP27A1(2), CYP7A1(4), HADHB(2), HSD3B7(1), LIPA(1), RDH13(1), SLC27A5(4), SOAT1(4), SRD5A1(1), SRD5A2(1) 6119347 44 35 44 14 28 1 7 3 5 0 0.364 1.000 1.000 493 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 DAXX(1), HMGN1(2), HRAS(6), HSPB2(2), MAP2K4(1), MAP3K1(3), MAP3K5(4), MAP3K7(3), MAP3K9(1), MAPK14(1), MAPKAPK2(1), MEF2A(1), MEF2C(2), MEF2D(1), MKNK1(1), MYC(1), RAC1(1), RIPK1(2), RPS6KA5(3), STAT1(4), TGFB3(1), TRADD(1), TRAF2(2) 7067862 45 35 44 16 23 3 12 2 5 0 0.806 1.000 1.000 494 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(3), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH4A1(1), ALDH9A1(2), AOC3(1), ARG2(1), ASL(3), CKMT2(2), CPS1(4), GATM(1), GLUD1(2), MAOA(1), NOS1(4), NOS3(6), ODC1(1), P4HA1(1), P4HA3(1), P4HB(3), PYCR1(3), RARS(1) 8547023 46 34 46 18 25 0 11 5 5 0 0.721 1.000 1.000 495 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(3), ALAS1(5), AMT(1), AOC3(1), CHKA(1), CHKB(3), CPT1B(2), CTH(2), DLD(2), DMGDH(2), GARS(1), GATM(1), GLDC(4), MAOA(1), PISD(2), PLCB2(1), PLCG1(3), PLCG2(3), PSPH(3), SARS(2), SHMT1(1) 8106773 44 34 44 15 20 2 13 3 6 0 0.532 1.000 1.000 496 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(2), ALG13(1), ALG2(2), ALG6(1), ALG9(1), B4GALT1(1), DHDDS(3), DOLPP1(1), DPM1(1), FUT8(5), GANAB(8), MAN1A1(3), MAN1A2(2), MAN1B1(5), MAN1C1(4), MAN2A1(5), MGAT1(4), MGAT2(1), MGAT3(1), MGAT4A(2), MGAT5B(1), ST6GAL1(1) 8150046 55 34 55 17 31 0 8 10 6 0 0.417 1.000 1.000 497 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 CALM1(1), CALM2(1), HRAS(6), MAP2K1(1), MAP2K3(2), MAP2K4(1), MAP3K1(3), MAPK14(1), MAPK3(3), MAPK8(4), PLCG1(3), PRKCA(1), PTK2B(3), RAC1(1), RAF1(1), SOS1(5), SRC(4), SYT1(2) 5506811 43 34 42 12 22 2 10 6 3 0 0.469 1.000 1.000 498 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(7), ASAH1(2), CASP3(1), CREB5(5), DAG1(1), EPHB2(3), FOS(3), ITPKA(2), ITPKB(1), MAP2K4(1), MAP2K7(2), MAPK10(1), MAPK8(4), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(3), MAPK9(5) 5514628 45 34 45 14 19 2 10 4 10 0 0.624 1.000 1.000 499 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(1), AKR1B10(1), B4GALT1(1), GAA(2), GALE(1), GALK1(1), GALT(1), GANC(3), GLA(1), GLB1(2), HK1(3), HK2(3), HK3(3), HSD3B7(1), LCT(4), MGAM(6), PFKP(1), PGM1(2), RDH13(1), UGP2(5) 7485376 43 33 42 25 25 1 7 4 6 0 0.966 1.000 1.000 500 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ACAA1(1), ACAA2(1), ACAT1(1), ALDH3A1(2), ALDH9A1(2), AOX1(2), AUH(1), BCAT1(1), BCAT2(1), BCKDHA(1), DBT(3), DLD(2), EHHADH(1), HADH(1), HADHA(3), HADHB(2), HMGCS1(1), HSD17B10(1), HSD17B4(3), IVD(1), MCCC1(5), MCCC2(2), MCEE(1), MUT(1), OXCT2(1) 8323222 41 33 41 11 26 1 6 2 6 0 0.443 1.000 1.000 501 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(1), GTF2A2(1), GTF2E1(1), GTF2E2(2), GTF2F1(1), GTF2H1(2), GTF2H3(1), GTF2I(2), GTF2IRD1(2), TAF1(2), TAF10(1), TAF12(2), TAF13(1), TAF1L(3), TAF2(3), TAF4(4), TAF4B(2), TAF5(1), TAF6(2), TAF6L(1), TAF7L(3), TAF9(1), TAF9B(1) 6957108 40 33 40 14 24 0 8 2 6 0 0.879 1.000 1.000 502 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDH(4), AASS(3), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2), BBOX1(1), DLST(1), DOT1L(9), EHHADH(1), EHMT1(2), EHMT2(4), GCDH(2), HADHA(3), PLOD1(1), PLOD2(3), SDS(1), SHMT1(1), TMLHE(1) 7137961 45 33 45 29 27 1 5 5 7 0 0.998 1.000 1.000 503 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(2), DLAT(1), DLD(2), ENO1(2), ENO2(1), ENO3(1), FBP1(1), GAPDHS(1), GPI(3), HK1(3), HK2(3), HK3(3), LDHAL6B(1), MDH1(1), PC(2), PCK1(3), PDHA2(2), PDHX(1), PFKP(1), PGAM1(1), PKLR(1), PKM2(2), TNFAIP1(1) 8224739 39 32 39 29 20 0 12 1 6 0 0.999 1.000 1.000 504 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(4), ACO1(1), ACO2(2), CLYBL(2), DLD(2), DLST(1), FH(3), IDH1(3), IDH3B(2), MDH1(1), OGDH(5), OGDHL(4), PC(2), PCK1(3), SDHA(3), SDHC(2), SUCLG1(1) 5778893 41 32 41 27 21 2 9 4 5 0 0.997 1.000 1.000 505 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(1), ARG2(1), ASL(3), ASS1(2), CKMT2(2), CPS1(4), EPRS(5), GATM(1), GLUD1(2), GLUD2(3), LAP3(1), NOS1(4), NOS3(6), P4HA1(1), P4HA3(1), PRODH(1), PYCR1(3), RARS(1), RARS2(2) 6953557 44 32 43 13 26 2 9 1 6 0 0.460 1.000 1.000 506 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 ATF1(1), CREB5(5), DUSP10(3), EEF2K(4), EIF4E(1), GADD45A(1), MAP2K3(2), MAP2K4(1), MAP3K10(1), MAP3K4(5), MAP3K5(4), MAP3K7(3), MAPK11(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPKAPK2(1), MKNK1(1), MYEF2(2), NFKB1(1), NR2C2(2), TRAF6(1) 6452082 44 32 43 17 19 2 9 2 12 0 0.849 1.000 1.000 507 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(3), GABBR1(2), GPRC5A(1), GPRC5D(1), GRM1(7), GRM2(5), GRM3(3), GRM4(1), GRM5(5), GRM7(4), GRM8(1) 4053491 33 31 32 15 16 0 12 2 3 0 0.660 1.000 1.000 508 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(2), CHIA(3), CHIT1(4), CMAS(1), CYB5R1(1), CYB5R3(2), GFPT1(1), GFPT2(1), GNE(4), GNPNAT1(1), HEXA(1), HEXB(2), HK1(3), HK2(3), HK3(3), LHPP(2), MTMR1(2), MTMR2(3), MTMR6(4), NAGK(2), RENBP(2), UAP1(1) 5545996 48 31 48 21 32 1 6 3 6 0 0.894 1.000 1.000 509 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 ACAT1(1), AKR1B10(1), ALDH3A1(2), ALDH9A1(2), BDH2(2), DDHD1(2), EHHADH(1), GAD1(5), HADH(1), HADHA(3), HMGCS1(1), HSD17B10(1), HSD17B4(3), HSD3B7(1), ILVBL(1), L2HGDH(1), OXCT2(1), PDHA2(2), PLA1A(2), PPME1(1), PRDX6(4), RDH13(1) 7845533 39 31 38 19 23 1 6 3 6 0 0.936 1.000 1.000 510 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(2), CALM1(1), CALM2(1), CALML3(1), CALML6(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), CLCA1(2), CLCA2(1), CLCA4(2), CNGA3(1), CNGB1(7), GNAL(1), GUCA1B(1), PDE1C(4), PRKACB(1), PRKG1(1), PRKG2(4), PRKX(1) 5889004 38 31 38 12 20 0 13 5 0 0 0.511 1.000 1.000 511 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(6), IKBKB(4), IL1A(1), IL1B(1), IL1RAP(1), IL6(2), IRAK2(1), IRAK3(3), MAP2K3(2), MAP3K1(3), MAP3K14(2), MAP3K7(3), MAPK14(1), MAPK8(4), MYD88(1), NFKB1(1), NFKBIA(2), RELA(2), TGFB3(1), TOLLIP(1), TRAF6(1) 5728160 43 31 43 16 22 1 8 3 9 0 0.814 1.000 1.000 512 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(1), BRAF(1), CREB5(5), DUSP4(1), DUSP6(3), EEF2K(4), EIF4E(1), MAP2K1(1), MAP3K8(2), MAPK3(3), MKNK1(1), MOS(2), NFKB1(1), RAP1A(1), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), SOS1(5), SOS2(4) 5698715 42 31 41 13 25 2 6 3 6 0 0.673 1.000 1.000 513 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(3), DLG4(3), EPHB2(3), F2RL1(3), F2RL3(1), MAPK7(2), MAPK8(4), MYEF2(2), PLD1(3), PLD2(1), PLD3(3), PTK2(3), RAF1(1), RASAL1(1), SRC(4), TEC(4), VAV1(2) 5299718 43 31 43 13 21 1 11 3 7 0 0.527 1.000 1.000 514 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABP1(3), ACADSB(1), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2), AOC3(1), CNDP1(1), DPYD(5), DPYS(5), EHHADH(1), GAD1(5), HADHA(3), SDS(1), UPB1(3) 5614107 36 30 36 13 18 0 9 6 3 0 0.675 1.000 1.000 515 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(1), ACAA2(1), ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), AKR1C4(1), AKR1D1(2), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2), BAAT(1), CEL(2), CYP27A1(2), CYP7A1(4), HADHB(2), SRD5A1(1), SRD5A2(1) 4481679 33 30 33 12 16 1 8 4 4 0 0.623 1.000 1.000 516 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(1), B4GALT1(1), GAA(2), GALE(1), GALK1(1), GALT(1), GANAB(8), GLA(1), GLB1(2), HK1(3), HK2(3), HK3(3), LCT(4), MGAM(6), PFKP(1), PGM1(2) 6303677 40 30 40 20 20 1 8 3 8 0 0.903 1.000 1.000 517 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(2), CALCR(2), CALCRL(2), CD97(3), CRHR2(1), EMR2(1), GHRHR(1), GIPR(1), GLP2R(1), GPR64(2), LPHN1(5), LPHN2(8), LPHN3(5), SCTR(3), VIPR1(1), VIPR2(4) 5135548 42 30 42 24 13 2 14 4 9 0 0.957 1.000 1.000 518 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(1), ALOX15(2), ALOX5(2), CYP1A2(2), CYP2C18(1), CYP2C19(1), CYP2C9(2), CYP2E1(1), CYP3A4(5), CYP3A43(1), CYP3A7(6), HSD3B7(1), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), RDH13(1) 4622175 34 30 34 14 19 0 4 3 8 0 0.698 1.000 1.000 519 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 ARSB(2), FUCA2(2), GALNS(1), GBA(2), GLB1(2), GNS(2), GUSB(1), HEXA(1), HEXB(2), HGSNAT(1), HPSE(3), HPSE2(1), HYAL2(2), IDS(1), LCT(4), MAN2B1(1), MAN2B2(1), MAN2C1(1), MANBA(2), NAGLU(1), NEU2(2), NEU4(1), SPAM1(1) 6653859 37 30 37 11 21 1 7 5 3 0 0.384 1.000 1.000 520 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2R(2), F2RL3(1), GNAI1(1), GNB1(5), HRAS(6), ITGA1(1), ITGB1(1), MAP2K1(1), MAPK3(3), PLCB1(4), PRKCA(1), PTK2(3), RAF1(1), SRC(4), SYK(1), TBXAS1(3) 4709578 38 30 37 13 18 2 11 7 0 0 0.702 1.000 1.000 521 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(1), BIRC3(1), CASP3(1), CASP8(4), CFLAR(1), FADD(1), MAP2K4(1), MAP3K7(3), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), NFKBIL2(2), NR2C2(2), RALBP1(1), RIPK1(2), TNFAIP3(2), TNFRSF1B(3), TRADD(1), TRAF2(2) 5270016 41 30 41 14 22 1 9 3 6 0 0.697 1.000 1.000 522 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(1), CHUK(6), IKBKB(4), MAP2K3(2), MAP2K4(1), MAP3K1(3), MAP3K14(2), MAP4K2(4), MAPK14(1), MAPK8(4), NFKB1(1), NFKBIA(2), RELA(2), RIPK1(2), TANK(1), TRADD(1), TRAF2(2) 4665487 39 30 39 13 20 3 6 3 7 0 0.661 1.000 1.000 523 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(4), CSF1R(6), EGF(4), EGFR(3), MET(5), PDGFRA(7), PRKCA(1), SH3KBP1(2), SRC(4) 3757386 36 29 36 12 18 1 11 5 1 0 0.649 1.000 1.000 524 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(4), EPOR(1), FOS(3), HRAS(6), JAK2(2), MAP2K1(1), MAPK3(3), MAPK8(4), PLCG1(3), RAF1(1), SOS1(5), STAT5B(2) 4154884 35 29 34 10 21 1 6 5 2 0 0.445 1.000 1.000 525 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(1), ALDOA(2), FBP1(1), FPGT(5), GMDS(3), GMPPA(1), GMPPB(2), HK1(3), HK2(3), HK3(3), MPI(2), PFKFB1(2), PFKFB3(3), PFKP(1), PMM1(3), PMM2(1) 4624722 36 29 36 16 24 0 4 2 6 0 0.749 1.000 1.000 526 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(1), EP300(26), HIF1A(1), NOS3(6), P4HB(3) 3281496 37 29 37 11 14 2 5 6 10 0 0.771 1.000 1.000 527 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(2), GPLD1(4), PGAP1(2), PIGB(3), PIGC(1), PIGF(2), PIGG(6), PIGK(3), PIGL(1), PIGM(1), PIGN(1), PIGO(2), PIGS(2), PIGT(1), PIGU(1), PIGV(1), PIGW(1), PIGZ(1) 4592986 35 29 35 13 19 2 7 2 5 0 0.578 1.000 1.000 528 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BNIP1(1), SEC22B(2), SNAP23(1), SNAP25(1), SNAP29(3), STX10(1), STX11(2), STX12(1), STX16(1), STX18(1), STX3(4), STX4(2), STX5(2), STX7(1), STX8(1), TSNARE1(3), USE1(1), VAMP4(1), VAMP5(1), VTI1B(3), YKT6(1) 3229386 34 29 34 12 23 0 6 3 2 0 0.661 1.000 1.000 529 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(4), ADRA1B(1), ADRA1D(2), ADRA2C(1), ADRB1(1), ADRB2(2), CHRM1(1), CHRM3(4), CHRM4(1), DRD3(1), HRH1(4), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(1), HTR1F(1), HTR2B(2), HTR2C(1), HTR4(2), HTR6(1), HTR7(1) 4935543 35 29 35 22 19 3 9 3 1 0 0.855 1.000 1.000 530 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(4), AP2A1(3), AP2M1(1), BIN1(1), CALM1(1), CALM2(1), DNM1(3), EPS15(2), PPP3CA(4), PPP3CB(4), PPP3CC(2), SYNJ1(3), SYNJ2(2), SYT1(2) 4214441 33 29 33 13 19 2 3 5 4 0 0.883 1.000 1.000 531 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(3), CDK7(3), ERCC3(2), GTF2A2(1), GTF2E1(1), GTF2E2(2), GTF2H1(2), MNAT1(1), POLR1A(5), POLR1B(1), POLR2B(1), POLR2C(2), POLR2E(1), POLR2F(1), POLR3B(3), POLR3E(2), POLR3H(1), TAF12(2), TAF13(1), TAF5(1), TAF6(2), TAF9(1) 6764726 39 29 39 14 22 1 5 3 8 0 0.809 1.000 1.000 532 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(3), ACTN1(2), ACTN2(3), ACTN3(2), CAPNS2(1), ITGA1(1), ITGB1(1), ITGB3(2), PTK2(3), RAC1(1), SPTAN1(34), SRC(4), TLN1(2) 5519831 59 29 59 18 38 2 9 1 9 0 0.571 1.000 1.000 533 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ALDH4A1(1), CAD(7), CPS1(4), EPRS(5), GAD1(5), GCLC(1), GCLM(1), GFPT1(1), GLS(1), GLS2(1), GLUD1(2), GMPS(2), GSS(1), NADSYN1(3), PPAT(2), QARS(3) 6420899 40 28 40 19 22 1 8 4 5 0 0.935 1.000 1.000 534 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 C1GALT1(1), C1GALT1C1(1), GALNT1(1), GALNT11(1), GALNT12(1), GALNT13(1), GALNT2(2), GALNT3(1), GALNT4(1), GALNT5(3), GALNT6(1), GALNT7(1), GALNT8(2), GALNT9(1), GALNTL2(3), GALNTL5(1), GCNT1(1), GCNT4(1), OGT(2), ST3GAL1(1), ST6GALNAC1(1), WBSCR17(3) 6230638 31 28 31 16 19 2 4 4 2 0 0.964 1.000 1.000 535 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(6), FADD(1), IKBKB(4), IL1A(1), MAP3K1(3), MAP3K14(2), MAP3K7(3), MYD88(1), NFKB1(1), NFKBIA(2), RELA(2), RIPK1(2), TLR4(3), TNFAIP3(2), TNFRSF1B(3), TRADD(1), TRAF6(1) 4699938 38 28 38 11 19 0 9 1 9 0 0.589 1.000 1.000 536 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(1), AKR1D1(2), ARSB(2), ARSD(2), CYP11B2(3), HSD17B3(1), HSD17B8(3), HSD3B1(2), HSD3B2(3), SRD5A1(1), SRD5A2(1), STS(2), SULT2A1(1), UGT1A1(3), UGT1A3(3), UGT1A5(1), UGT1A6(1), UGT1A9(2), UGT2B4(2) 5258278 36 27 36 12 20 3 9 3 1 0 0.470 1.000 1.000 537 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ACACA(13), ACACB(5), ACAT1(1), ACSS1(1), ALDH3A1(2), ALDH9A1(2), EHHADH(1), HADHA(3), LDHAL6A(1), LDHAL6B(1), MCEE(1), MUT(1), SUCLG1(1) 7678824 33 27 32 14 21 0 3 3 6 0 0.848 1.000 1.000 538 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), BCAT2(1), COASY(2), DPYD(5), DPYS(5), ENPP1(2), ILVBL(1), PANK1(2), PANK2(2), PANK3(2), PANK4(2), PPCDC(1), PPCS(2), UPB1(3), VNN1(1) 3345916 32 27 32 11 16 0 9 6 1 0 0.663 1.000 1.000 539 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 FAU(2), MRPL13(1), MRPS7(1), RPL10A(1), RPL11(2), RPL13(1), RPL22L1(1), RPL23A(1), RPL24(2), RPL26(2), RPL28(1), RPL3(1), RPL31(3), RPL35A(1), RPL37(1), RPL3L(1), RPL6(1), RPL7(1), RPS13(1), RPS18(4), RPS6(3), RPS7(1), RPS9(1) 4382331 34 27 34 21 23 1 9 1 0 0 0.957 1.000 1.000 540 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(5), C5(3), ICAM1(3), IL1A(1), IL6(2), IL8(1), ITGA4(6), ITGAL(2), ITGB1(1), ITGB2(3), SELP(1), VCAM1(1) 4777049 29 27 29 12 17 1 8 2 1 0 0.801 1.000 1.000 541 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(3), CAPNS2(1), CXCR3(1), EGF(4), EGFR(3), HRAS(6), ITGA1(1), ITGB1(1), MAPK3(3), MYL2(2), MYLK(5), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PTK2(3), TLN1(2) 6323151 42 27 41 15 22 2 13 3 2 0 0.676 1.000 1.000 542 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(1), ANXA2(1), ANXA4(1), ANXA5(1), ANXA6(3), CYP11A1(1), EDNRA(1), EDNRB(2), PRL(2), PTGDR(3), PTGER2(1), PTGER4(2), PTGFR(2), PTGIR(1), PTGIS(1), PTGS2(2), S100A6(1), TBXAS1(3) 3977901 29 27 29 15 12 0 15 1 1 0 0.923 1.000 1.000 543 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(1), APC(7), AXIN1(3), CTNNB1(4), DLL1(4), NOTCH1(5), PSEN1(5) 4134022 29 27 29 14 14 1 5 2 7 0 0.982 1.000 1.000 544 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(3), COL4A2(5), COL4A3(5), COL4A4(4), COL4A5(2), COL4A6(1), P4HB(3), SLC2A1(3), SLC2A3(4) 4799749 30 27 29 13 13 2 8 3 4 0 0.964 1.000 1.000 545 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(1), AGT(1), AGTR2(1), EDNRA(1), EDNRB(2), EGF(4), EGFR(3), FOS(3), HRAS(6), MYC(1), NFKB1(1), PLCG1(3), PRKCA(1), RELA(2) 3969332 30 26 29 11 14 1 12 1 2 0 0.656 1.000 1.000 546 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(1), BIRC3(1), CASP1(2), CASP3(1), CASP4(2), CASP6(1), CASP8(4), CASP9(3), DFFA(4), LMNA(1), LMNB1(2), LMNB2(1), PRF1(4) 3736459 27 26 27 12 14 0 7 2 4 0 0.923 1.000 1.000 547 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT2(1), AGPAT3(2), AGPS(2), CHPT1(2), ENPP2(1), PAFAH1B1(1), PAFAH1B2(1), PAFAH2(1), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), PLD1(3), PLD2(1), PPAP2A(5), PPAP2B(1), PPAP2C(1) 4483989 30 26 30 12 18 0 2 3 7 0 0.829 1.000 1.000 548 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(2), DLAT(1), DLD(2), DLST(1), FH(3), IDH3B(2), MDH1(1), OGDH(5), PC(2), PDHA2(2), PDHX(1), PDK2(1), SDHA(3), SDHC(2), SUCLG1(1) 5487307 29 26 29 20 16 2 7 2 2 0 0.996 1.000 1.000 549 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ACACA(13), ACADSB(1), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2), EHHADH(1), HADHA(3), MCEE(1), MUT(1), SDS(1), SUCLG1(1) 6399478 30 26 30 17 21 0 2 2 5 0 0.983 1.000 1.000 550 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(1), ACAA2(1), ACADSB(1), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2), AOX1(2), BCAT1(1), BCKDHA(1), EHHADH(1), HADHA(3), HADHB(2), IVD(1), MCCC1(5), MCCC2(2), MCEE(1), MUT(1), SDS(1) 6960225 32 26 32 16 23 0 5 1 3 0 0.961 1.000 1.000 551 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CARM1(2), CTH(2), GGT1(1), LCMT2(1), MAT1A(2), METTL2B(1), PRMT5(3), PRMT6(1), PRMT7(5), PRMT8(4), SCLY(1), WBSCR22(3) 4827465 26 25 25 10 13 3 3 5 2 0 0.702 1.000 1.000 552 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP5(3), ACP6(1), ACPP(5), ACPT(3), ALPI(2), ALPL(1), CYP3A4(5), CYP3A43(1), CYP3A7(6), DHRS1(1), DHRS7(2), DHRSX(3), PON1(1), PON2(1) 3476482 35 24 34 17 18 2 7 1 7 0 0.891 1.000 1.000 553 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(8), ABCC2(2), BCHE(3), CES2(2), CYP3A4(5), UGT1A1(3), UGT1A3(3), UGT1A5(1), UGT1A6(1), UGT1A9(2) 4408319 30 24 30 11 17 2 6 3 2 0 0.566 1.000 1.000 554 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(1), CCR1(1), CCR3(3), CCR4(2), CCR5(2), CCR7(3), CD4(1), CXCR3(1), CXCR4(2), IFNG(1), IFNGR2(2), IL12B(2), IL12RB1(2), IL12RB2(1), IL18R1(1), IL4R(1), TGFB3(1) 3867274 27 24 27 11 10 1 9 4 3 0 0.757 1.000 1.000 555 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(1), CALM2(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), CAMK4(1), ESRRA(2), HDAC5(2), MEF2A(1), MEF2C(2), MEF2D(1), PPP3CA(4), PPP3CB(4), PPP3CC(2), SLC2A4(1), SYT1(2) 3904632 30 24 30 12 13 2 5 6 4 0 0.791 1.000 1.000 556 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(1), ADSL(1), ADSS(2), ASL(3), ASPA(2), CAD(7), CRAT(5), DARS(2), GAD1(5), NARS(1), PC(2) 5044734 31 23 31 14 17 0 6 5 3 0 0.838 1.000 1.000 557 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(4), CHAT(2), COMT(2), DBH(3), DDC(3), GAD1(5), HDC(2), MAOA(1), PAH(3), SLC18A3(1) 2779711 26 23 26 15 11 1 9 1 4 0 0.956 1.000 1.000 558 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(3), CD2(1), CD33(2), CD5(1), CD7(2), IFNG(1), IL12B(2), TLR2(2), TLR4(3), TLR7(6), TLR9(2) 3589504 25 23 25 10 12 1 6 2 4 0 0.639 1.000 1.000 559 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(3), GCLC(1), GCLM(1), GGT1(1), GPX3(2), GPX6(2), GSR(2), GSS(1), GSTA1(1), GSTA2(1), GSTA4(1), GSTA5(2), GSTM2(1), GSTM3(1), GSTM5(2), GSTP1(2), GSTZ1(1), IDH1(3), OPLAH(1) 4255262 29 23 29 14 13 2 7 2 5 0 0.834 1.000 1.000 560 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP5(3), ACP6(1), ACPP(5), ACPT(3), ENPP1(2), FLAD1(1), LHPP(2), MTMR1(2), MTMR2(3), MTMR6(4), RFK(1), TYR(3) 2905957 30 23 29 11 18 2 7 1 2 0 0.824 1.000 1.000 561 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), COASY(2), DPYD(5), DPYS(5), ENPP1(2), PANK1(2), PANK2(2), PANK3(2), PANK4(2), PPCS(2), UPB1(3) 2693978 28 23 28 10 14 0 8 5 1 0 0.743 1.000 1.000 562 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(2), AGT(1), AGTR2(1), COL4A1(3), COL4A2(5), COL4A3(5), COL4A4(4), COL4A5(2), COL4A6(1), REN(2) 4830988 26 21 25 11 9 0 10 2 5 0 0.965 1.000 1.000 563 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(1), ACO2(2), DLD(2), DLST(1), FH(3), IDH1(3), IDH3B(2), MDH1(1), PC(2), PCK1(3), SDHA(3), SUCLG1(1) 3984886 24 21 24 13 12 0 7 2 3 0 0.949 1.000 1.000 564 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AP2A1(3), AP2M1(1), BTK(3), EEA1(6), GRASP(2), GSK3A(1), LYN(2), PDPK1(1), PFKP(1), PLCG1(3), PRKCZ(2), RAB5A(1), RAC1(1), VAV2(1) 4869144 28 21 28 11 17 0 6 4 1 0 0.738 1.000 1.000 565 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(19), CDC25A(1), CHEK1(1), MYT1(3), WEE1(2) 2657515 26 20 26 11 11 2 4 4 5 0 0.953 1.000 1.000 566 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(2), FBP1(1), GPI(3), H6PD(5), PFKP(1), PGD(1), PGM1(2), RBKS(1), RPIA(2), TKTL1(3), TKTL2(1) 4707229 22 20 22 12 9 0 8 1 4 0 0.873 1.000 1.000 567 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(4), EXT2(3), EXTL1(1), EXTL2(2), EXTL3(2), GLCE(1), HS2ST1(1), HS3ST5(1), HS6ST1(1), NDST2(1), NDST3(2), NDST4(2) 3985201 21 20 21 12 12 0 3 3 3 0 0.917 1.000 1.000 568 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(4), IL22RA1(1), JAK1(3), JAK2(2), JAK3(3), STAT1(4), STAT5B(2), TYK2(2) 3562698 21 20 21 12 11 0 2 3 5 0 0.940 1.000 1.000 569 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 ICAM1(3), ITGA4(6), ITGAL(2), ITGAM(3), ITGB1(1), ITGB2(3), SELE(1), SELP(1) 3076178 20 20 20 11 13 0 5 2 0 0 0.941 1.000 1.000 570 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(1), DARS(2), EPRS(5), GARS(1), KARS(3), LARS(1), LARS2(1), NARS(1), QARS(3), RARS(1), SARS(2), YARS(3) 6194728 24 19 24 14 14 1 5 1 3 0 0.980 1.000 1.000 571 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(1), CYB5R3(2), GFPT1(1), GNE(4), HEXA(1), HEXB(2), HK1(3), HK2(3), HK3(3), RENBP(2), UAP1(1) 3278556 23 18 23 16 14 1 4 0 4 0 0.992 1.000 1.000 572 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2), EHHADH(1), GAD1(5), HADHA(3), L2HGDH(1), PDHA2(2), SDS(1) 4989515 21 18 21 15 12 0 4 1 4 0 0.994 1.000 1.000 573 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(3), GCLC(1), GCLM(1), GGT1(1), GPX3(2), GSS(1), GSTA1(1), GSTA2(1), GSTA4(1), GSTM2(1), GSTM3(1), GSTM5(2), GSTP1(2), GSTZ1(1), IDH1(3), PGD(1) 3491974 23 18 23 12 13 1 4 0 5 0 0.846 1.000 1.000 574 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT2(3), B3GAT3(1), B4GALT7(1), CHPF(2), CHST11(1), CHST12(1), CHST14(1), CHST7(1), CHSY1(2), DSE(2), UST(1), XYLT1(3), XYLT2(2) 2684031 21 18 21 10 12 1 3 3 2 0 0.758 1.000 1.000 575 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(2), CD3E(1), CXCR3(1), ETV5(1), IFNG(1), IL12B(2), IL12RB1(2), IL12RB2(1), IL18R1(1), JAK2(2), MAPK14(1), MAPK8(4), STAT4(1), TYK2(2) 3598829 22 18 22 20 11 0 8 2 1 0 1.000 1.000 1.000 576 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(3), EPHB1(4), FYN(1), ITGA1(1), ITGB1(1), L1CAM(2), LYN(2), RAP1B(2), SELP(1) 3053500 17 16 17 10 11 1 4 1 0 0 0.957 1.000 1.000 577 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 ICAM1(3), ITGA4(6), ITGAL(2), ITGB1(1), ITGB2(3), SELE(1) 2335119 16 16 16 8 10 0 4 2 0 0 0.892 1.000 1.000 578 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(2), CD2(1), CD3E(1), CD4(1), CXCR3(1), IFNG(1), IL12B(2), IL12RB1(2), IL12RB2(1), JAK2(2), STAT4(1), TYK2(2) 2835218 17 16 17 14 8 0 7 1 1 0 0.996 1.000 1.000 579 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(1), CNR2(3), DNMT1(4), MTNR1A(1), PTAFR(1), PTGDR(3), PTGER2(1), PTGER4(2), PTGFR(2), PTGIR(1) 2160318 19 15 19 13 7 1 9 1 1 0 0.912 1.000 1.000 580 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(4), ACO1(1), ACO2(2), ACSS1(1), FH(3), IDH1(3), MDH1(1) 2571940 15 14 15 12 8 0 2 2 3 0 0.987 1.000 1.000 581 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(2), FH(3), MDH1(1), OGDH(5), SDHA(3) 1818782 14 14 14 10 6 1 4 2 1 0 0.979 1.000 1.000 582 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP5(3), ACPP(5), ACPT(3), ENPP1(2), FLAD1(1), RFK(1), TYR(3) 1873311 18 14 17 10 10 1 6 0 1 0 0.964 1.000 1.000 583 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(1), CALM2(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), CAMK4(1), CAMKK2(3), SYT1(2) 2229297 14 13 14 10 7 0 2 1 4 0 0.982 1.000 1.000 584 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 HK1(3), HK2(3), HK3(3), IMPA1(1), IMPA2(1), ISYNA1(1), PGM1(2) 2263142 14 13 14 11 9 0 2 1 2 0 0.987 1.000 1.000 585 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), ASRGL1(1), CA12(1), CA4(1), CPS1(4), CTH(2), GLS(1), GLS2(1), GLUD1(2), GLUD2(3), HAL(3) 4102451 20 13 20 10 9 1 7 0 3 0 0.934 1.000 1.000 586 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(2), CD38(1), ENPP1(2), NADSYN1(3), NNMT(1), NNT(1), NT5E(3), QPRT(2) 2810480 15 13 15 6 8 2 4 1 0 0 0.792 1.000 1.000 587 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(3), JAK2(2), JAK3(3), MAPK3(3), TYK2(2) 2273441 13 13 13 11 7 0 2 3 1 0 0.990 1.000 1.000 588 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(3), APAF1(1), CASP3(1), CASP9(3), DAXX(1), HSPB2(2), IL1A(1), MAPKAPK2(1) 2194483 13 12 13 10 6 2 3 0 2 0 0.988 1.000 1.000 589 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 ICAM1(3), ITGAL(2), ITGAM(3), ITGB2(3), SELE(1) 2005411 12 12 12 7 7 0 4 1 0 0 0.889 1.000 1.000 590 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ITPKA(2), PDE1A(2), PLCB1(4), PLCB2(1), PRL(2), TRH(1) 2143051 12 12 12 5 5 0 5 2 0 0 0.779 1.000 1.000 591 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 HK1(3), HK2(3), HK3(3), IMPA1(1), PGM1(2) 1982881 12 12 12 10 8 0 2 0 2 0 0.990 1.000 1.000 592 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(4), MDH1(1), ME1(2), PC(2), SLC25A1(1), SLC25A11(1) 1792284 11 11 11 11 8 0 2 0 1 0 0.991 1.000 1.000 593 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(4), CHAT(2), CHKA(1), PCYT1A(1), PDHA2(2), SLC18A3(1) 1346557 11 10 11 10 3 1 7 0 0 0 0.988 1.000 1.000 594 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS2(3), CTH(2), LDHAL6A(1), LDHAL6B(1), SDS(1), SULT1C2(1), SULT1C4(2) 2426832 11 10 11 5 3 1 6 1 0 0 0.846 1.000 1.000 595 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(1), CDC25A(1), CSK(4), PRKCA(1), PTPRA(1), SRC(4) 1788561 12 10 12 8 6 2 3 1 0 0 0.957 1.000 1.000 596 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ENO1(2), GPI(3), HK1(3), PGAM1(1), PKLR(1) 1800386 10 9 10 10 6 0 2 1 1 0 0.990 1.000 1.000 597 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(2), CHST11(1), CHST12(1), SULT1A1(1), SULT2A1(1), SULT2B1(1), SUOX(1) 1787499 8 8 8 11 5 0 1 2 0 0 0.999 1.000 1.000 598 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(1), GPD2(1), SDHA(3), SDHC(2) 1280620 7 7 7 6 4 1 2 0 0 0 0.985 1.000 1.000 599 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(4), APOBEC1(2), APOBEC2(1), APOBEC4(1) 1417496 8 7 8 4 6 0 1 1 0 0 0.836 1.000 1.000 600 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 HDAC9(2), MEF2A(1), MEF2C(2), MEF2D(1), MYOD1(1) 1461085 7 7 7 6 2 1 3 1 0 0 0.979 1.000 1.000 601 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMPR1A(1), BMPR1B(2), BMPR2(5) 1206668 8 7 8 5 8 0 0 0 0 0 0.948 1.000 1.000 602 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASS(3), KARS(3) 908261 6 6 6 5 4 0 1 1 0 0 0.987 1.000 1.000 603 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(1), EPHX2(2), HSD3B7(1), RDH13(1) 929465 5 5 5 5 4 1 0 0 0 0 0.933 1.000 1.000 604 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), LARS(1), LARS2(1), PDHA2(2) 1933941 5 5 5 3 3 0 2 0 0 0 0.933 1.000 1.000 605 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(2), ALDH1A2(1), BCMO1(1) 753607 4 4 4 4 2 0 1 1 0 0 0.969 1.000 1.000 606 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(1), PLCD1(1), PRKCA(1), TGM2(1) 964152 4 4 4 3 2 0 0 2 0 0 0.916 1.000 1.000 607 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(2), SULT2A1(1), SUOX(1) 1180420 4 4 4 8 2 0 1 1 0 0 1.000 1.000 1.000 608 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(2), CD3E(1), CD4(1) 620923 4 3 4 5 2 0 1 1 0 0 0.986 1.000 1.000 609 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CTH(2) 1323441 2 2 2 3 0 1 1 0 0 0 0.986 1.000 1.000 610 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 PGLYRP2(1) 351636 1 1 1 2 0 1 0 0 0 0 0.983 1.000 1.000 611 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 GSTZ1(1) 430986 1 1 1 3 1 0 0 0 0 0 0.994 1.000 1.000 612 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 318050 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 613 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 509080 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 614 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 140554 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 615 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 98540 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 616 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 295672 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000