rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(2), MTMR1(2), MTMR2(3), MTMR6(4), NFS1(3), THTPA(1), TPK1(2) 1240248 17 14 17 0 12 0 1 1 3 0 0.0192 0.0682 1.000 2 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 12 APC(7), CDH1(6), CREBBP(18), MAP2K1(1), MAP3K7(3), MAPK3(3), SKIL(5), TGFB3(1), TGFBR2(3) 4004092 47 36 46 4 20 0 9 4 14 0 0.0163 0.107 1.000 3 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(3), HLA-DRA(1), HLA-DRB1(1) 588486 5 5 5 1 0 0 3 1 1 0 0.618 0.185 1.000 4 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(3), IL8(1) 331437 4 4 4 0 2 0 0 0 2 0 0.401 0.186 1.000 5 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 6 CDK2(1), CUL1(8), E2F1(1) 939186 10 10 9 1 8 0 1 0 1 0 0.189 0.191 1.000 6 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(2), GBA(2), GBA3(2), LPO(4), MPO(2), PRDX6(4), TPO(9) 1614846 25 21 24 4 10 0 9 3 3 0 0.105 0.217 1.000 7 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), IFNG(1), JAK1(3), JAK2(2), PLA2G2A(1), PTPRU(4), REG1A(3), STAT1(4) 2213957 19 18 19 1 11 0 4 2 2 0 0.0269 0.230 1.000 8 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 5 CREBBP(18), LPL(1), NCOA1(10), NCOA2(4), PPARG(3) 2424867 36 31 35 6 15 0 10 1 10 0 0.194 0.290 1.000 9 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(3), GNAS(4), GNB1(5), PRKAR1A(1) 1281408 13 11 13 2 6 2 2 1 2 0 0.262 0.291 1.000 10 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(2), IFNG(1), IL12B(2) 572591 5 5 5 0 1 0 2 0 2 0 0.287 0.293 1.000 11 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(3), RAB11A(1), RAB3A(1), RAB5A(1) 819403 6 6 6 0 2 2 0 1 1 0 0.254 0.304 1.000 12 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(1), COQ3(1), COQ5(2), COQ6(2), NDUFA12(1), NDUFA13(2) 772198 9 9 9 2 5 1 2 0 1 0 0.530 0.311 1.000 13 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(1), IFNGR2(2), JAK1(3), JAK2(2), STAT1(4) 1580572 12 12 12 1 5 1 1 2 3 0 0.176 0.321 1.000 14 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 11 CDK2(1), CDKN1B(5), CUL1(8), E2F1(1), SKP2(1) 1324860 16 15 15 3 10 0 2 0 4 0 0.290 0.335 1.000 15 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(2), GBA3(2), LPO(4), MPO(2), PRDX1(2), PRDX2(4), PRDX5(1), PRDX6(4), TPO(9), TYR(3) 1859703 33 24 32 6 16 0 11 2 4 0 0.0856 0.399 1.000 16 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SEC61A2(1), SRP19(3), SRP54(1), SRP68(8), SRP72(1), SRP9(1), SRPR(3) 1458879 18 16 18 3 8 0 3 2 5 0 0.336 0.419 1.000 17 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(1), CYP2C9(2) 390328 3 3 3 1 2 0 1 0 0 0 0.686 0.471 1.000 18 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(1), IL6(2), IL6R(1), JAK1(3), JAK2(2), JAK3(3), PIAS3(1), PTPRU(4), REG1A(3), SRC(4) 2958697 24 20 24 2 14 1 6 2 1 0 0.0173 0.479 1.000 19 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(2), DHRS1(1), DHRS7(2), DHRSX(3), LCMT2(1), METTL2B(1), PRMT5(3), PRMT6(1), PRMT7(5), PRMT8(4), WBSCR22(3) 2911761 26 24 25 3 13 2 5 5 1 0 0.0400 0.489 1.000 20 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 8 CCNA1(1), CDK2(1), CUL1(8), E2F1(1), SKP2(1) 1317003 12 12 11 2 8 0 3 0 1 0 0.273 0.501 1.000 21 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 7 HBXIP(1), PTK2B(3), SOS1(5), SRC(4) 1620163 13 12 13 1 10 0 3 0 0 0 0.122 0.504 1.000 22 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 6 CREBBP(18), MAPK3(3), PELP1(2), SRC(4) 1885311 27 26 26 6 10 0 9 2 6 0 0.244 0.512 1.000 23 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD4(1), HLA-DRA(1), HLA-DRB1(1) 458593 3 3 3 1 1 0 2 0 0 0 0.697 0.534 1.000 24 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(3), GABARAP(1), GABRA1(1), GABRA2(1), GABRA3(1), GABRA4(5), GABRA5(3), GABRA6(3), GPHN(1), NSF(1), SRC(4) 2294116 24 20 24 4 10 2 8 2 2 0 0.168 0.552 1.000 25 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(1), GABRA2(1), GABRA3(1), GABRA4(5), GABRA5(3), GABRA6(3), SOD1(2) 1509277 16 15 16 4 5 1 6 2 2 0 0.438 0.567 1.000 26 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(3), CASP1(2), CASP3(1), CASP8(4), INSR(4), ITCH(5), MAGI1(4), MAGI2(7), RERE(8), WWP1(2), WWP2(2) 4648148 42 33 41 4 22 1 9 5 5 0 0.0134 0.581 1.000 27 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(4), ST3GAL1(1), ST3GAL5(2), ST6GALNAC4(1), ST8SIA1(1) 1093542 9 8 9 2 3 0 1 3 2 0 0.403 0.594 1.000 28 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(15), MAP2(5), PPP1CA(4), PPP2CA(1), PRKACB(1), PRKAG1(2), PRKAR2A(3), PRKAR2B(1) 3498828 32 23 32 2 21 2 4 2 3 0 0.0368 0.602 1.000 29 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(3), GAD1(5), HDC(2) 1161532 10 9 10 2 4 0 2 1 3 0 0.449 0.619 1.000 30 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(2), CTSD(3), GREB1(5), HSPB2(2), MTA1(2), PDZK1(1), TUBA8(1) 2114916 16 14 16 2 4 1 10 0 1 0 0.0793 0.650 1.000 31 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(1), GNB1(5), HTR2C(1), PLCB1(4), TUB(1) 1378016 12 10 12 2 5 2 2 2 1 0 0.296 0.658 1.000 32 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(2), CYP2E1(1), NR1I3(2), PTGS2(2) 1033131 7 6 7 1 5 0 1 0 1 0 0.248 0.681 1.000 33 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK1(3), JAK2(2), JAK3(3), PIAS3(1), PTPRU(4), REG1A(3), SOAT1(4) 2652266 21 19 21 3 13 1 4 2 1 0 0.104 0.687 1.000 34 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(1), FUT1(2), FUT2(1), FUT3(1), FUT5(1) 977979 6 6 6 0 1 0 5 0 0 0 0.119 0.706 1.000 35 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 16 CSNK2A1(4), FOS(3), KLK2(1), MAP2K1(1), MAPK3(3), MAPK8(4), NGFR(3), PIK3R1(2), PLCG1(3), RAF1(1), SOS1(5) 3188051 30 22 30 4 16 1 4 6 3 0 0.0733 0.708 1.000 36 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1), GLS2(1), GLUD1(2), GLUD2(3) 879132 7 6 7 2 2 0 3 0 2 0 0.721 0.709 1.000 37 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(1) 220138 1 1 1 1 1 0 0 0 0 0 0.934 0.713 1.000 38 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(2), PDXK(3), PNPO(2), PSAT1(1) 937306 8 8 8 4 3 0 0 1 4 0 0.899 0.723 1.000 39 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(1), GALT(1), UGDH(2), UGP2(5) 947897 9 9 8 2 6 0 1 1 1 0 0.530 0.733 1.000 40 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(3), AOC3(1), ESD(2) 1163257 6 6 6 0 2 0 3 1 0 0 0.155 0.734 1.000 41 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 10 CREBBP(18), DAXX(1), PAX3(4), PML(3), RARA(3), SIRT1(1), SP100(6), TNFRSF1B(3) 3078811 39 34 37 7 18 0 13 2 6 0 0.113 0.752 1.000 42 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CLOCK(1), CRY1(1), CRY2(3), CSNK1E(1), PER1(3) 1637148 9 9 9 1 2 0 4 1 2 0 0.416 0.763 1.000 43 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(3), FOSL1(1), FOSL2(3), IFNAR1(1), IFNAR2(1), MAPK8(4), NFKB1(1), RELA(2), TNFSF11(1), TRAF6(1) 2142418 18 15 18 3 8 0 4 1 5 0 0.348 0.787 1.000 44 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(1), IDI2(3) 820497 4 4 4 0 1 0 2 1 0 0 0.355 0.795 1.000 45 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(1), B3GALT5(1), B3GNT5(6), FUT1(2), FUT2(1), FUT3(1) 1391160 12 8 12 1 7 0 5 0 0 0 0.0810 0.803 1.000 46 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(3), CD3E(1), CD4(1), CREBBP(18), CSK(4), GNAS(4), GNB1(5), HLA-DRA(1), HLA-DRB1(1), LCK(1), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PTPRC(5), ZAP70(1) 4429484 52 37 51 9 21 4 13 3 11 0 0.0532 0.804 1.000 47 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(3), CD3E(1), CD4(1), CREBBP(18), CSK(4), GNAS(4), GNB1(5), HLA-DRA(1), HLA-DRB1(1), LCK(1), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PTPRC(5), ZAP70(1) 4429484 52 37 51 9 21 4 13 3 11 0 0.0532 0.804 1.000 48 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(2), DAG1(1), ITPKA(2), ITPKB(1) 1165072 6 6 6 1 4 0 1 1 0 0 0.434 0.806 1.000 49 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(1) 407844 1 1 1 0 0 0 1 0 0 0 0.762 0.810 1.000 50 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(3), ACTR3(1), ARPC2(3), ARPC4(1), RAC1(1), WASL(1) 1568083 10 9 10 1 7 1 1 1 0 0 0.262 0.811 1.000 51 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), HADH(1), HADHA(3), HADHB(2), HSD17B10(1), HSD17B4(3), MECR(1), PPT2(1) 1636994 13 9 13 0 10 1 0 1 1 0 0.0238 0.815 1.000 52 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2) 1088874 8 8 8 2 5 0 2 1 0 0 0.535 0.821 1.000 53 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(1), GNAS(4), GNB1(5), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(1) 1861490 18 11 18 2 8 3 4 2 1 0 0.138 0.824 1.000 54 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(1), B3GNT1(1), FUT1(2), FUT2(1), FUT9(1), GCNT2(1), ST8SIA1(1) 1180654 8 7 8 2 2 0 4 2 0 0 0.480 0.828 1.000 55 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 CAT(3), EPX(2), LPO(4), MPO(2), PRDX1(2), PRDX2(4), PRDX5(1), PRDX6(4), SHMT1(1), TPO(9) 2280013 32 24 31 5 18 0 8 3 3 0 0.0408 0.831 1.000 56 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(2), CHPT1(2), LCMT2(1), METTL2B(1), PCYT1A(1), PRMT5(3), PRMT6(1), PRMT7(5), PRMT8(4), WBSCR22(3) 2722705 23 22 22 4 13 2 3 5 0 0 0.187 0.839 1.000 57 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(3), TYR(3) 908525 6 6 6 2 3 0 3 0 0 0 0.653 0.847 1.000 58 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 11 CARM1(2), CREBBP(18), NCOA3(5), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), RARA(3) 2858623 35 26 34 6 13 2 10 2 8 0 0.138 0.867 1.000 59 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(1), CREBBP(18), DFFA(4), GZMA(4), HMGB2(4), PRF1(4) 2040378 35 30 34 9 15 0 11 2 7 0 0.401 0.884 1.000 60 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 12 ARF3(1), CCND1(1), CDK2(1), CDK4(2), CDKN1B(5), E2F1(1), E2F2(1), PRB1(1) 1300222 13 11 13 4 6 0 1 1 5 0 0.654 0.885 1.000 61 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 CTH(2), MUT(1) 946870 3 3 3 0 1 1 1 0 0 0 0.474 0.887 1.000 62 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), BIRC3(1), CASP8(4), FADD(1), RIPK1(2), TNFRSF1B(3), TRADD(1), TRAF2(2) 1622003 15 14 15 3 8 0 4 2 1 0 0.328 0.887 1.000 63 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(3), CD4(1), HLA-DRA(1), HLA-DRB1(1), IL1B(1), IL5RA(2), IL6(2) 1032374 11 11 11 4 5 0 3 2 1 0 0.670 0.889 1.000 64 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA5(1), NDUFA8(1), NDUFB5(1), NDUFB6(1), NDUFS1(2), NDUFS2(1), NDUFV1(2) 1345812 9 9 9 2 3 0 4 1 1 0 0.547 0.891 1.000 65 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), LDLR(2), MBTPS1(4), SCAP(3), SREBF1(4), SREBF2(2) 2309312 16 15 16 3 7 0 5 2 2 0 0.235 0.892 1.000 66 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACAT1(1), HADHA(3) 1044366 4 4 4 1 3 0 0 0 1 0 0.753 0.895 1.000 67 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5O(1), ATP6V0A1(6), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(6), ATP6V1C1(3), ATP6V1E1(1), ATP6V1G2(1), ATP6V1H(4), FDXR(3), SHMT1(1) 3098582 33 26 33 6 15 3 6 5 4 0 0.0960 0.898 1.000 68 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(1), CSF1(2), IL6(2), LDLR(2), LPL(1) 1029629 8 8 8 3 4 0 2 0 2 0 0.772 0.902 1.000 69 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(1), FMOD(1), KERA(2) 697527 4 4 4 2 2 0 2 0 0 0 0.808 0.903 1.000 70 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(1), NFKBIA(2), PLCB1(4), PRKCA(1), RELA(2) 1590882 10 9 10 2 4 0 2 3 1 0 0.463 0.906 1.000 71 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(1), ACAA2(1), ACAT1(1), EHHADH(1), HADHA(3), HADHB(2), SDS(1) 1617062 10 8 10 1 9 0 0 0 1 0 0.231 0.906 1.000 72 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(2), CYP2A13(3), CYP2A6(3), CYP2A7(3), NAT1(2), XDH(6) 1543255 19 19 19 5 8 0 4 4 3 0 0.338 0.907 1.000 73 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(6), DNAJC3(2), MAP3K14(2), NFKB1(1), NFKBIA(2), RELA(2) 1735159 15 13 15 3 8 0 2 0 5 0 0.449 0.911 1.000 74 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD3E(1), CD8A(2), ICAM1(3), ITGAL(2), ITGB2(3), PTPRC(5) 2069086 17 16 17 4 7 1 4 2 3 0 0.283 0.917 1.000 75 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6V0A1(6), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(6), ATP6V1C1(3), ATP6V1E1(1), ATP6V1G2(1), ATP6V1H(4), SHMT1(1) 2910134 30 24 30 6 12 3 6 5 4 0 0.163 0.918 1.000 76 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6V0A1(6), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(6), ATP6V1C1(3), ATP6V1E1(1), ATP6V1G2(1), ATP6V1H(4), SHMT1(1) 2910134 30 24 30 6 12 3 6 5 4 0 0.163 0.918 1.000 77 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6V0A1(6), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(6), ATP6V1C1(3), ATP6V1E1(1), ATP6V1G2(1), ATP6V1H(4), SHMT1(1) 2910134 30 24 30 6 12 3 6 5 4 0 0.163 0.918 1.000 78 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP3(1), CASP8(4), CFLAR(1) 748523 6 6 6 2 3 0 1 1 1 0 0.694 0.918 1.000 79 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP3(1), DFFA(4), HMGB1(1), HMGB2(4), TOP2A(7), TOP2B(2) 1704993 19 18 19 4 14 0 2 1 2 0 0.597 0.919 1.000 80 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 13 ACTR3(1), ARPC2(3), ARPC4(1), PDGFRA(7), PIK3R1(2), RAC1(1), WASL(1) 2165512 16 16 16 3 8 0 6 1 1 0 0.363 0.919 1.000 81 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(1) 653008 1 1 1 2 0 0 0 0 1 0 1.000 0.924 1.000 82 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(1), GLS(1), GLUD1(2), PRODH(1) 1074281 5 4 5 1 3 1 1 0 0 0 0.589 0.924 1.000 83 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(1), JUNB(4), MAF(1), MAP2K3(2), MAPK14(1), NFATC1(4), NFATC2(6), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1) 2347929 26 18 26 5 9 3 6 3 5 0 0.164 0.926 1.000 84 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(1), SNAP25(1) 629498 2 2 2 0 2 0 0 0 0 0 0.470 0.928 1.000 85 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 12 CCNA1(1), CCND1(1), CCNE2(1), CDK2(1), CDK4(2), CDKN1B(5), E2F1(1), E2F2(1), E2F4(1), PRB1(1) 1628071 15 12 15 4 8 0 2 1 4 0 0.551 0.937 1.000 86 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 CAT(3), EPX(2), LPO(4), MPO(2), MTHFR(1), PRDX6(4), SHMT1(1), TPO(9) 2243863 26 21 25 5 13 0 8 3 2 0 0.134 0.939 1.000 87 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 11 CDK5(1), CDK5R1(1), EGR1(1), KLK2(1), MAP2K1(1), MAPK3(3), NGFR(3), RAF1(1) 1505802 12 9 12 3 4 1 1 4 2 0 0.518 0.940 1.000 88 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(2), CYP11A1(1), CYP11B2(3), CYP21A2(1), HSD3B1(2), HSD3B2(3) 1793052 13 10 13 3 6 0 5 2 0 0 0.289 0.947 1.000 89 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(2), CYP11A1(1), CYP11B2(3), CYP21A2(1), HSD3B1(2), HSD3B2(3) 1793052 13 10 13 3 6 0 5 2 0 0 0.289 0.947 1.000 90 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(2), GGT1(1), SHMT1(1) 794800 4 4 4 3 1 0 1 0 2 0 0.947 0.949 1.000 91 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 5 LDLR(2) 869753 2 2 2 0 1 0 0 0 1 0 0.509 0.952 1.000 92 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOA(2) 756956 2 2 2 1 2 0 0 0 0 0 0.792 0.956 1.000 93 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 4 EGF(4), EGFR(3), NRG1(5) 1440140 12 11 12 3 5 0 5 2 0 0 0.564 0.959 1.000 94 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(1), CDK5R1(1), GRM1(7), PLCB1(4), PPP1CA(4), PPP1R1B(1), PPP2CA(1), PPP3CA(4), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1) 3096119 30 22 30 6 10 2 7 6 5 0 0.229 0.959 1.000 95 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(1), CD3E(1), HLA-A(5), ICAM1(3), ITGAL(2), ITGB2(3), PRF1(4) 1692530 19 18 18 6 7 0 6 2 4 0 0.486 0.965 1.000 96 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(1), MYC(1), SP1(3), SP3(2), WT1(2) 1204545 9 7 9 3 4 1 0 1 3 0 0.710 0.965 1.000 97 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(1), ALAS1(5), FECH(1), PPOX(4), UROD(1), UROS(2) 1462080 14 13 14 6 6 0 3 1 4 0 0.865 0.968 1.000 98 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 EHHADH(1), HADHA(3), SDS(1) 936834 5 5 5 2 5 0 0 0 0 0 0.695 0.969 1.000 99 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(1), IL10RA(4), IL10RB(3), IL1A(1), IL6(2), JAK1(3), STAT1(4) 2364136 18 15 18 4 9 0 0 3 6 0 0.243 0.971 1.000 100 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR2(1), GPR161(3), GPR171(1), GPR39(2), GPR45(3), GPR65(1), GPR68(2), GPR75(6), GPR81(3) 1894848 22 17 22 7 10 0 5 3 4 0 0.327 0.972 1.000 101 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(1), ALAS1(5), FECH(1), GATA1(4), UROD(1), UROS(2) 1509673 14 11 14 6 6 1 2 1 4 0 0.851 0.972 1.000 102 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(1), EHHADH(1), GCDH(2), HADHA(3), SDS(1) 1510121 8 7 8 2 7 0 0 0 1 0 0.587 0.972 1.000 103 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(1), CYP11A1(1), CYP11B2(3), HSD3B1(2), HSD3B2(3) 1337035 10 8 10 3 6 0 4 0 0 0 0.352 0.973 1.000 104 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(3), ADRB2(2), CFTR(2), GNAS(4), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1) 2527486 18 15 18 4 7 1 5 2 3 0 0.375 0.974 1.000 105 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), FLT3(3), IL1A(1), IL6(2), KITLG(2), TGFB3(1) 1611076 10 10 10 3 7 0 0 1 2 0 0.591 0.976 1.000 106 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 HLCS(3) 593573 3 3 3 2 3 0 0 0 0 0 0.848 0.980 1.000 107 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNG(1), IL12B(2), IL16(2), IL1A(1), IL6(2), IL8(1) 1910836 9 9 9 2 5 0 3 0 1 0 0.377 0.981 1.000 108 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(1) 611494 1 1 1 0 1 0 0 0 0 0 0.747 0.984 1.000 109 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(1), FOSB(1), GRIA2(3), JUND(1), PPP1R1B(1) 720820 7 7 7 3 5 0 0 1 1 0 0.838 0.984 1.000 110 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(2), ARFGAP3(3), ARFGEF2(4), CLTB(1), COPA(5), GBF1(8), GPLD1(4) 3142494 27 21 27 5 18 2 4 1 2 0 0.153 0.985 1.000 111 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(2), FDPS(1), HMGCR(1), HMGCS1(1), LSS(3), NSDHL(1), PMVK(1), SC4MOL(4), SC5DL(1) 2550982 15 12 15 3 9 2 1 3 0 0 0.308 0.985 1.000 112 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(1), GBA(2), GBA3(2), GGT1(1), SHMT1(1) 1057334 7 7 7 5 2 0 2 1 2 0 0.961 0.987 1.000 113 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(3), ALDH3A1(2), ALDH3B1(2), AOC3(1), DDC(3), EPX(2), HPD(2), LPO(4), MAOA(1), MPO(2), PRDX1(2), PRDX2(4), PRDX5(1), PRDX6(4), TPO(9) 4244493 42 32 41 7 23 0 12 3 4 0 0.0165 0.987 1.000 114 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(3), GNAS(4), GNB1(5), PPP2CA(1), PRKAA2(4), PRKAB2(1), PRKACB(1), PRKAG1(2), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1) 2974081 27 19 27 5 10 4 8 1 4 0 0.230 0.989 1.000 115 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ASL(3), CPS1(4), GLS(1), GLUD1(2) 1500433 10 6 10 3 7 0 2 0 1 0 0.606 0.989 1.000 116 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), CSAD(1), GAD1(5), GGT1(1) 1112933 8 8 8 8 4 0 2 0 2 0 0.992 0.990 1.000 117 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(7), AGT(1), AGTR2(1), KNG1(1), NOS3(6), REN(2) 1919184 18 17 17 5 11 0 6 0 1 0 0.271 0.991 1.000 118 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(13), ACACB(5), FASN(2), MCAT(1), OXSM(2) 3092336 23 22 22 5 16 1 1 3 2 0 0.217 0.991 1.000 119 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(3), PRKCA(1), PTK2B(3) 1297367 8 8 8 3 6 0 1 1 0 0 0.614 0.992 1.000 120 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 18 CCNA1(1), CCNB1(1), CCND1(1), CCNH(3), CDC25A(1), CDK2(1), CDK4(2), CDK6(1), CDK7(3), CDKN1B(5), CDKN2B(2), CDKN2D(1), E2F1(1), RBL1(1) 2484828 24 18 24 5 13 1 4 1 5 0 0.328 0.993 1.000 121 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(1), GALT(1), UGDH(2) 744595 4 4 4 2 2 0 1 1 0 0 0.861 0.993 1.000 122 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(1), P2RY1(1), P2RY2(1) 1152233 3 3 3 2 2 0 0 1 0 0 0.753 0.994 1.000 123 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 18 ADCY1(3), ARHGEF1(6), F2R(2), F2RL3(1), GNA13(5), GNAI1(1), GNB1(5), MAP3K7(3), PIK3R1(2), PLCB1(4), PPP1R12B(2), PRKCA(1), PTK2B(3), ROCK1(4) 4564931 42 27 41 7 22 2 5 5 8 0 0.103 0.994 1.000 124 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(1), B4GALT1(1), FUT8(5), ST3GAL1(1) 1522294 8 8 8 3 4 0 1 3 0 0 0.698 0.994 1.000 125 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(3), POLD2(3), POLE(6), POLQ(8) 3244322 20 17 20 4 12 0 3 1 4 0 0.250 0.995 1.000 126 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(1), ACOX3(3), FADS2(1), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1) 1963243 13 12 13 4 5 0 3 3 2 0 0.567 0.995 1.000 127 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 6 LPL(1), NR3C1(1), PPARG(3) 935658 5 5 5 5 3 0 1 0 1 0 0.989 0.995 1.000 128 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(1), ACOX1(1), ACOX3(3), ELOVL5(1), ELOVL6(1), FADS1(2), FADS2(1), FASN(2), HADHA(3), SCD(1) 2805082 16 14 16 4 10 0 3 1 2 0 0.280 0.996 1.000 129 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD4(1), HLA-DRA(1), HLA-DRB1(1) 767428 3 3 3 2 1 0 2 0 0 0 0.866 0.996 1.000 130 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 5 NFYA(1), SP1(3), SP3(2) 949204 6 5 6 3 4 0 0 1 1 0 0.861 0.996 1.000 131 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 ABO(1), B3GNT1(1), B3GNT2(2), B3GNT4(1), B3GNT5(6), B4GALT1(1), FUT1(2), FUT2(1), FUT3(1), FUT5(1), FUT9(1), GCNT2(1), ST3GAL6(2), ST8SIA1(1) 3112564 22 14 22 4 12 0 5 4 1 0 0.149 0.996 1.000 132 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP2(10), RANGAP1(2) 1625665 13 11 13 3 6 2 2 1 2 0 0.717 0.996 1.000 133 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 B3GALT5(1), FUT1(2), FUT2(1), FUT9(1), GLA(1), HEXA(1), HEXB(2), NAGA(1), ST3GAL1(1), ST8SIA1(1) 2074499 12 12 12 4 6 0 4 1 1 0 0.570 0.996 1.000 134 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(5), PRKACB(1), PRKAG1(2), PRKAR2A(3), PRKAR2B(1) 1950855 12 8 12 3 8 1 1 0 2 0 0.560 0.997 1.000 135 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(6), APOA4(2), APOC1(1), CETP(2), CYP7A1(4), DGAT1(1), HMGCR(1), LCAT(1), LDLR(2), LIPC(5), LPL(1), LRP1(12), SCARB1(1), SOAT1(4) 5300968 43 31 43 8 25 1 8 2 7 0 0.0530 0.997 1.000 136 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(3), F13A1(2), F2R(2), FGA(7), FGB(1), FGG(3), PLAT(1), PLAU(1), SERPINB2(1), SERPINE1(2) 2585938 23 19 23 5 10 0 8 1 4 0 0.356 0.997 1.000 137 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(1), ERBB4(3), NRG3(3), PRKCA(1), PSEN1(5) 1736379 13 13 13 4 6 1 3 1 2 0 0.698 0.997 1.000 138 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(1), ADSS(2), IMPDH1(1), MTHFD2(2), POLD1(3), RRM1(1), SRM(2) 2427855 12 10 12 3 4 1 6 0 1 0 0.519 0.997 1.000 139 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 10 ARNT(1), EPOR(1), GRIN1(6), HIF1A(1), JAK2(2), NFKB1(1), NFKBIA(2), RELA(2) 2376782 16 13 16 4 10 0 3 1 2 0 0.503 0.997 1.000 140 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(3), CR2(6), FCGR2B(1), HLA-DRA(1), HLA-DRB1(1), ICAM1(3), ITGAL(2), ITGB2(3), PTPRC(5) 2918637 25 24 25 6 9 2 8 3 3 0 0.342 0.997 1.000 141 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 FDPS(1), HMGCR(1), LSS(3), PMVK(1), SC5DL(1), VKORC1(1) 2139206 8 8 8 2 5 1 1 1 0 0 0.499 0.997 1.000 142 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(3), FHL5(1), FSHR(1), GNAS(4), XPO1(3) 1853617 12 9 12 5 6 0 1 2 3 0 0.855 0.998 1.000 143 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), ENO2(1), ENO3(1), PAH(3), YARS(3) 1606332 10 10 10 6 2 1 3 1 3 0 0.934 0.998 1.000 144 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 21 CXCR4(2), GNAI1(1), GNB1(5), MAP2K1(1), MAPK3(3), NFKB1(1), PIK3C2G(3), PIK3R1(2), PLCG1(3), PRKCA(1), PTK2(3), PTK2B(3), RAF1(1), RELA(2) 4813979 31 24 31 4 18 2 4 5 2 0 0.0486 0.998 1.000 145 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT1(2), FUT2(1), FUT9(1), GLA(1), HEXA(1), HEXB(2), NAGA(1), ST3GAL1(1), ST8SIA1(1) 1954235 11 11 11 4 6 0 3 1 1 0 0.625 0.998 1.000 146 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(1), CD8A(2), CSF1(2), IL6(2), IL7(1), IL8(1) 1182748 9 9 9 4 6 1 2 0 0 0 0.679 0.998 1.000 147 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 12 FOS(3), KEAP1(5), MAFF(1), MAFK(1), MAPK14(1), MAPK8(4), PRKCA(1) 1484357 16 12 16 7 6 1 4 2 3 0 0.847 0.998 1.000 148 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 6 CDC25A(1), CDK7(3), CHEK1(1), WEE1(2) 1253135 7 6 7 3 4 1 0 0 2 0 0.910 0.998 1.000 149 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(6), ABCB4(3), ABCC1(8), ABCC3(8), GSTP1(2) 2756497 27 22 27 8 15 2 5 4 1 0 0.319 0.998 1.000 150 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 38 ANAPC1(5), ANAPC2(3), ANAPC4(3), ANAPC5(1), ANAPC7(2), CDC16(1), CDC27(3), CUL1(8), CUL2(4), CUL3(1), FBXW11(1), FZR1(2), ITCH(5), SKP1(1), SKP2(1), SMURF1(4), SMURF2(1), UBA1(1), UBE2C(1), UBE2D3(1), WWP1(2), WWP2(2) 7431892 53 36 52 6 26 6 8 4 9 0 0.0322 0.998 1.000 151 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(2), IL1B(1), MST1(3), MST1R(5) 1265983 11 10 11 9 5 1 3 1 1 0 0.973 0.999 1.000 152 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(1), CDK5R1(1), DAB1(4), FYN(1), RELN(13), VLDLR(2) 2709901 22 18 22 5 10 2 5 2 3 0 0.458 0.999 1.000 153 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(1), BDH2(2), HMGCS1(1), OXCT2(1) 1392249 5 5 5 4 0 1 2 1 1 0 0.981 0.999 1.000 154 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 19 B2M(1), HLA-A(5), ITGB1(1), KLRC4(2), KLRD1(1), LAT(1), MAP2K1(1), MAPK3(3), PIK3R1(2), PTK2B(3), RAC1(1), SYK(1), VAV1(2) 3165634 24 21 23 8 9 0 5 3 7 0 0.754 0.999 1.000 155 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 F13B(1), HSD17B1(1), HSD17B3(1), HSD17B4(3), HSD3B1(2), HSD3B2(3) 1559341 11 10 11 4 8 0 2 1 0 0 0.666 0.999 1.000 156 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD3E(1), CD4(1), ICAM1(3), ITGAL(2), ITGB2(3), PTPRC(5) 2169711 16 15 16 5 8 0 3 2 3 0 0.460 0.999 1.000 157 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 18 BCL2L1(2), CASP9(3), CHUK(6), H2AFX(2), MAP2K1(1), MAPK3(3), NFKB1(1), PIK3R1(2), RAC1(1), RAF1(1), RALBP1(1), RALGDS(2), RELA(2) 3103701 27 22 27 7 11 0 4 3 9 0 0.563 0.999 1.000 158 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(1), ARHGAP5(8), CASP1(2), CASP3(1), CASP8(4), CASP9(3), PRF1(4) 2492970 23 21 23 9 9 0 6 3 5 0 0.866 0.999 1.000 159 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2) 1544046 7 7 7 6 3 0 1 1 2 0 0.960 0.999 1.000 160 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2) 1544046 7 7 7 6 3 0 1 1 2 0 0.960 0.999 1.000 161 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(1), CD34(2), CD3E(1), CD4(1), CD58(1), CD8A(2), IL6(2), IL8(1), KITLG(2) 1198088 13 12 13 7 7 1 2 1 2 0 0.881 0.999 1.000 162 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(2), ALPL(1), FPGS(1), GCH1(1) 1247548 5 5 5 5 3 0 1 0 1 0 0.955 0.999 1.000 163 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(2), PARK2(2), SNCAIP(3), UBE2L6(1) 1240898 8 7 8 8 3 2 1 1 1 0 0.996 0.999 1.000 164 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 16 DNAJA3(1), HSPA1A(2), IFNG(1), IFNGR2(2), IKBKB(4), JAK2(2), NFKB1(1), NFKBIA(2), RELA(2), TNFRSF1B(3), USH1C(1), WT1(2) 3004817 23 22 23 5 12 1 6 0 4 0 0.282 0.999 1.000 165 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 16 CD3E(1), CD86(1), HLA-DRA(1), HLA-DRB1(1), ICOS(2), ITK(2), LCK(1), PIK3R1(2) 2049659 11 10 11 3 3 0 5 2 1 0 0.581 0.999 1.000 166 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(4), AASS(3), KARS(3) 1340895 10 10 10 5 5 1 1 2 1 0 0.934 0.999 1.000 167 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3E(1), IFNG(1), IL2RA(1), TGFB3(1), TGFBR2(3), TGFBR3(7), TOB1(4) 2050270 18 18 18 5 12 0 4 0 2 0 0.526 0.999 1.000 168 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(5), C5(3), C8A(2), C9(5) 2415790 15 14 15 4 6 1 6 1 1 0 0.568 0.999 1.000 169 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(6), IKBKAP(4), IKBKB(4), MAP3K1(3), MAP3K14(2), NFKB1(1), NFKBIA(2), RELA(2), RIPK1(2), TANK(1), TNFAIP3(2), TNFRSF1B(3), TRAF2(2) 4338292 34 30 34 7 16 2 8 2 6 0 0.233 0.999 1.000 170 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 21 ACTA1(3), ADCY1(3), CAP1(5), CCNB1(1), GNAI1(1), GNAS(4), GNB1(5), MAPK3(3), MYT1(3), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), RPS6KA1(1), SRC(4) 3906553 40 28 40 8 18 4 9 5 4 0 0.142 0.999 1.000 171 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(1), BAX(1), BCL10(1), BCL2L1(2), CASP8AP2(7), CASP9(3) 2075485 15 14 15 5 7 0 3 2 3 0 0.813 0.999 1.000 172 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH3A1(2), ALDH9A1(2), UGDH(2) 1647021 6 6 6 5 3 0 0 1 2 0 0.949 0.999 1.000 173 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 8 MMP14(1), MMP2(2), MMP9(3), RECK(1) 1373560 7 7 7 8 1 2 3 0 1 0 0.998 0.999 1.000 174 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(2), CAPNS2(1), CDK5(1), CDK5R1(1), CSNK1A1(3), MAPT(5), PPP2CA(1) 1789183 14 11 14 7 6 0 3 2 3 0 0.943 0.999 1.000 175 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 9 EGF(4), EGFR(3), MAP2K1(1), MAP3K1(3), MAPK14(1), NCOR2(10), RARA(3) 3166251 25 24 25 6 8 0 10 3 4 0 0.400 0.999 1.000 176 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), B4GALT7(1), XYLT1(3), XYLT2(2) 1257884 7 7 7 4 4 1 1 1 0 0 0.765 1.000 1.000 177 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), B4GALT7(1), XYLT1(3), XYLT2(2) 1257884 7 7 7 4 4 1 1 1 0 0 0.765 1.000 1.000 178 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 FOS(3), MAPK3(3), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1) 2490456 13 10 13 4 5 1 4 1 2 0 0.573 1.000 1.000 179 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(1), CD36(1), FOS(3), FYN(1), MAPK14(1) 1430515 7 6 7 3 3 0 1 1 2 0 0.815 1.000 1.000 180 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3E(1), CD4(1), FYN(1), HLA-DRA(1), HLA-DRB1(1), LCK(1), PTPRC(5), ZAP70(1) 1735611 12 9 12 5 6 0 3 1 2 0 0.771 1.000 1.000 181 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 CTH(2), DNMT1(4), DNMT3A(1), DNMT3B(1), MAT1A(2), MTR(3) 3367042 13 12 13 3 7 1 2 1 2 0 0.380 1.000 1.000 182 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 13 CASP9(3), CHUK(6), GHR(2), NFKB1(1), NFKBIA(2), PDPK1(1), PIK3R1(2), PPP2CA(1), RELA(2) 2302089 20 16 20 5 8 0 6 0 6 0 0.519 1.000 1.000 183 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(1), DLL1(4), FURIN(2), NOTCH1(5), PSEN1(5) 1780063 17 16 17 8 8 1 5 1 2 0 0.883 1.000 1.000 184 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARSA(1), FARSB(2), PAH(3), YARS(3), YARS2(1) 1680288 10 10 10 4 3 1 3 1 2 0 0.744 1.000 1.000 185 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 11 CAT(3), GHR(2), IGF1R(5), PIK3R1(2), SOD1(2) 2063730 14 14 14 7 4 0 4 3 3 0 0.884 1.000 1.000 186 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(2), GSS(1), IL8(1), NFKB1(1), NOX1(1), RELA(2), SOD1(2), XDH(6) 1918966 16 14 16 7 7 0 6 0 3 0 0.730 1.000 1.000 187 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(1), BAX(1), BCL2L1(2), BIRC3(1), CASP3(1), CASP6(1), CASP8(4), CASP9(3), DFFA(4) 2601865 18 17 18 6 8 0 5 1 4 0 0.765 1.000 1.000 188 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(19), ATR(3), CHEK1(1), CHEK2(5) 2924427 28 21 28 9 16 1 3 3 5 0 0.871 1.000 1.000 189 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CEBPB(3), CSNK2A1(4), FOS(3), IL6(2), IL6R(1), IL6ST(3), JAK1(3), JAK2(2), JAK3(3), MAP2K1(1), MAPK3(3), RAF1(1), SOS1(5) 4535851 34 26 34 6 19 1 2 8 4 0 0.138 1.000 1.000 190 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(2), BFAR(2), BRAF(1), CREB5(5), RAF1(1), SNX13(4), SRC(4), TERF2IP(2) 2151152 21 17 21 6 10 1 3 3 4 0 0.593 1.000 1.000 191 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(1), CCNH(3), CDC25A(1), CDK7(3), MNAT1(1), XPO1(3) 1670908 12 9 12 5 7 1 1 1 2 0 0.858 1.000 1.000 192 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 FUCA2(2), GLB1(2), HEXA(1), HEXB(2), LCT(4), MAN2C1(1), MANBA(2), NEU2(2), NEU4(1) 3185924 17 16 17 4 11 1 3 1 1 0 0.376 1.000 1.000 193 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(1), IFNAR2(1), JAK1(3), STAT1(4), STAT2(2), TYK2(2) 2088938 13 11 13 9 5 0 2 2 4 0 0.957 1.000 1.000 194 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(2), CYP51A1(2), DHCR24(2), FDPS(1), GGCX(2), HMGCR(1), IDI2(3), LSS(3), NSDHL(1), PMVK(1), SC4MOL(4), SC5DL(1), TM7SF2(1), VKORC1(1) 3729681 25 19 25 6 14 2 4 5 0 0 0.267 1.000 1.000 195 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 15 CDKN1B(5), ITGB1(1), MAPK3(3), PDK2(1), PDPK1(1), PIK3R1(2), PTEN(5), PTK2(3), SOS1(5) 3310495 26 19 26 9 16 0 3 1 6 0 0.829 1.000 1.000 196 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(1), CASP8(4), FADD(1), MAP2K1(1), MAP2K4(1), MAP3K1(3), MAPK3(3), MAPK8(4), NFKB1(1), NSMAF(4), RAF1(1), RELA(2), RIPK1(2), SMPD1(3), TRADD(1), TRAF2(2) 3971477 34 29 34 8 15 1 6 6 6 0 0.319 1.000 1.000 197 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 B4GALT1(1), DPM1(1), FUT8(5), MAN1A1(3), MAN1B1(5), MGAT1(4), MGAT2(1), MGAT3(1), MGAT4A(2), ST6GAL1(1) 3840331 24 17 24 5 13 0 4 7 0 0 0.224 1.000 1.000 198 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(1), BIRC3(1), CASP3(1), CASP8(4), CASP9(3), DFFA(4), PRF1(4), SCAP(3), SREBF1(4), SREBF2(2) 3530946 27 25 27 7 11 0 10 3 3 0 0.416 1.000 1.000 199 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 18 CSNK2A1(4), FOS(3), IGF1R(5), IRS1(3), MAP2K1(1), MAPK3(3), MAPK8(4), PIK3R1(2), RAF1(1), RASA1(4), SOS1(5) 4279004 35 29 35 8 17 1 5 7 5 0 0.330 1.000 1.000 200 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 16 ADRB2(2), ANXA1(1), CALM1(1), CALM2(1), GNAS(4), GNB1(5), NFKB1(1), NOS3(6), NR3C1(1), PIK3R1(2), RELA(2), SYT1(2) 3041424 28 23 28 7 14 2 5 3 4 0 0.497 1.000 1.000 201 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(8), ARHGEF1(6), GNA13(5), GNB1(5), MYL2(2), MYLK(5), PLCB1(4), PPP1R12B(2), PRKCA(1), ROCK1(4) 3997666 42 27 41 9 24 2 3 8 5 0 0.307 1.000 1.000 202 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACSL1(1), CPT1A(2), EHHADH(1), HADHA(3), SCP2(2) 3254546 9 9 9 1 9 0 0 0 0 0 0.234 1.000 1.000 203 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 6 PIK3R1(2), PLCB1(4), PLCG1(3), PRKCA(1), VAV1(2) 2057139 12 12 12 5 4 0 3 3 2 0 0.806 1.000 1.000 204 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 CALM1(1), CALM2(1), MARCKS(1), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKCA(1), SP1(3), SP3(2), SYT1(2) 3980077 37 30 37 9 20 3 3 6 5 0 0.395 1.000 1.000 205 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 UBE2A(1), UBE2B(1), UBE2C(1), UBE2D3(1), UBE2I(1), UBE2J1(4), UBE2L6(1), UBE2N(2), UBE2S(1), UBE3A(5) 2030812 18 14 18 8 9 3 3 1 2 0 0.903 1.000 1.000 206 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(1), PSMA5(1), PSMA6(1), PSMB1(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB8(2), PSMB9(1) 1690643 11 11 11 5 7 0 2 1 1 0 0.857 1.000 1.000 207 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(3), EIF4E(1), FBL(1), MAPK14(1), NCL(1) 1735727 7 7 7 7 5 0 1 0 1 0 0.989 1.000 1.000 208 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 18 CCND1(1), CDK2(1), CDK4(2), CDK6(1), CDKN1B(5), E2F1(1), MAPK3(3), NFKB1(1), NFKBIA(2), PIK3R1(2), RAC1(1), RAF1(1), RELA(2) 3008422 23 20 23 7 13 0 3 2 5 0 0.571 1.000 1.000 209 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(6), MAP3K14(2), MAPK14(1), MAPK8(4), NFKB1(1), RELA(2), TNFRSF13C(1), TNFSF13B(3), TRAF2(2), TRAF6(1) 2807196 23 18 23 8 13 0 3 2 5 0 0.722 1.000 1.000 210 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(1), ACO2(2), FH(3), IDH1(3), MDH1(1) 1720729 10 10 10 5 5 0 2 2 1 0 0.861 1.000 1.000 211 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), ALDH3A1(2), ALDH9A1(2) 2556311 12 12 12 4 7 0 2 1 2 0 0.559 1.000 1.000 212 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(1), CALM2(1), DLG4(3), GRIN1(6), GRIN2A(9), GRIN2B(3), GRIN2C(5), GRIN2D(2), NOS1(4), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(1), SYT1(2) 4942895 54 37 54 12 23 5 12 9 5 0 0.129 1.000 1.000 213 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(3), ANKRD1(1), DUSP14(2), EIF4E(1), EIF4EBP1(1), IFNG(1), IFRD1(2), IL1A(1), JUND(1), MYOG(1), NR4A3(1), WDR1(2) 2067085 17 15 17 6 9 3 3 0 2 0 0.716 1.000 1.000 214 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 13 ERCC3(2), GTF2A1(1), GTF2E1(1), GTF2F1(1), NCOA1(10), NCOA2(4), NCOA3(5), NCOR2(10), RARA(3) 4644066 37 31 37 8 18 0 10 2 7 0 0.300 1.000 1.000 215 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(1), JAK1(3), PTPRU(4), REG1A(3), STAT1(4), STAT2(2), TYK2(2) 2418601 19 15 19 9 8 0 5 2 4 0 0.771 1.000 1.000 216 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), BCAT2(1), IARS2(2), ILVBL(1), LARS(1), LARS2(1), PDHA2(2), VARS(3), VARS2(4) 3595155 16 16 16 4 10 1 5 0 0 0 0.457 1.000 1.000 217 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 CHUK(6), IFNG(1), IKBKB(4), MAP3K1(3), MAP3K5(4), MAP4K5(1), MAPK14(1), MAPK8(4), NFKB1(1), NFKBIA(2), RELA(2), TNFRSF9(2), TRAF2(2) 3720840 33 27 33 9 15 0 9 2 7 0 0.550 1.000 1.000 218 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA5(1), PSMA6(1), PSMB1(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMC2(8), PSMC3(2), PSMD1(4), PSMD11(3), PSMD12(2), PSMD6(1) 3091312 28 23 28 9 21 0 2 1 4 0 0.671 1.000 1.000 219 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 21 CSNK2A1(4), FOS(3), IL2RA(1), IL2RB(2), IL2RG(3), JAK1(3), JAK3(3), LCK(1), MAP2K1(1), MAPK3(3), MAPK8(4), RAF1(1), SOS1(5), STAT5B(2), SYK(1) 4424432 37 29 37 9 18 1 7 8 3 0 0.261 1.000 1.000 220 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(1), CALM2(1), CCR5(2), CXCR4(2), FOS(3), MAPK14(1), MAPK8(4), PLCG1(3), PRKCA(1), PTK2B(3), SYT1(2) 2661183 23 21 23 9 10 0 4 5 4 0 0.784 1.000 1.000 221 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 14 CHUK(6), CREBBP(18), FADD(1), IKBKB(4), NFKB1(1), NFKBIA(2), RELA(2), RIPK1(2), TNFRSF1B(3), TRADD(1), TRAF6(1) 3367521 41 34 40 10 17 0 11 2 11 0 0.301 1.000 1.000 222 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(1), DHRS1(1), DHRS7(2), DHRSX(3), HSD3B7(1), PON1(1), PON2(1), RDH13(1) 1745635 11 10 11 7 6 0 4 0 1 0 0.888 1.000 1.000 223 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX15(2), ALOX5(2), DPEP1(2), GGT1(1), LTA4H(1), PLA2G2A(1), PLA2G6(1), PTGIS(1), PTGS2(2), TBXAS1(3) 2910685 16 13 16 9 7 0 3 2 4 0 0.877 1.000 1.000 224 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(3), ACTR3(1), ARPC2(3), ARPC4(1), NCK1(1), NCKAP1(5), NTRK1(4), PIR(1), RAC1(1), WASF2(3), WASF3(1), WASL(1) 2952250 25 20 25 6 16 1 5 2 1 0 0.459 1.000 1.000 225 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(7), CSF1(2), IL1B(1), IL6R(1), SPN(1), TNFRSF1B(3), TNFRSF8(4), TNFSF8(3) 2560010 22 17 21 6 12 0 8 1 1 0 0.351 1.000 1.000 226 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(1), GLI2(4), GLI3(10), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), SMO(2) 3224307 24 19 24 9 8 1 11 0 4 0 0.721 1.000 1.000 227 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(6), IKBKAP(4), IKBKB(4), MAP3K1(3), MAP3K14(2), NFKB1(1), NFKBIA(2), RELA(2), TNFAIP3(2), TRAF6(1) 3505989 27 23 27 8 14 1 5 1 6 0 0.621 1.000 1.000 228 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(2), GALNS(1), GLB1(2), GNS(2), GUSB(1), HEXA(1), HEXB(2), IDS(1), LCT(4), NAGLU(1) 2785263 17 17 17 5 10 1 2 3 1 0 0.470 1.000 1.000 229 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABP1(3), ALDH3A1(2), ALDH9A1(2), AOC3(1), CNDP1(1), DPYD(5), DPYS(5), EHHADH(1), GAD1(5), HADHA(3), SRM(2), UPB1(3) 5220751 33 27 33 7 15 1 9 5 3 0 0.190 1.000 1.000 230 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 12 AKT3(1), MAP2K1(1), NGFR(3), NTRK1(4), PIK3CD(3), SOS1(5) 2562882 17 15 17 5 11 0 3 3 0 0 0.519 1.000 1.000 231 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(3), ACY3(3), ALDH3A1(2), ALDH3B1(2), ALDH9A1(2), AOC3(1), ASPA(2), CARM1(2), CNDP1(1), DDC(3), HAL(3), HDC(2), HNMT(1), LCMT2(1), MAOA(1), METTL2B(1), PRMT5(3), PRMT6(1), PRMT7(5), PRMT8(4), UROC1(1), WBSCR22(3) 7659402 47 42 46 9 22 2 12 7 4 0 0.0621 1.000 1.000 232 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2), EHHADH(1), HADHA(3), SDS(1) 2349921 12 11 12 6 8 0 1 1 2 0 0.794 1.000 1.000 233 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(4), GLB1(2), HEXA(1), HEXB(2), LCT(4), SLC33A1(3), ST3GAL1(1), ST3GAL5(2), ST6GALNAC3(2), ST6GALNAC4(1), ST6GALNAC5(3), ST6GALNAC6(1), ST8SIA1(1) 3182798 27 25 27 9 15 1 4 5 2 0 0.483 1.000 1.000 234 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(1), ACO2(2), GRHPR(1), HAO1(1), HAO2(1), HYI(2), MDH1(1), MTHFD1(2), MTHFD1L(2), MTHFD2(2) 2474259 15 14 15 7 5 0 7 1 2 0 0.874 1.000 1.000 235 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CTH(2), GGT1(1), MAT1A(2), SCLY(1) 2392384 6 6 6 8 2 1 1 0 2 0 0.996 1.000 1.000 236 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(7), ACE2(2), AGT(1), AGTR2(1), ANPEP(3), CPA3(3), CTSG(3), ENPEP(3), LNPEP(1), MME(4), REN(2), THOP1(3) 4093353 33 27 32 9 19 0 6 3 5 0 0.326 1.000 1.000 237 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(2), ACTN2(3), ACTN3(2), CSK(4), CTNNA1(1), CTNNA2(2), CTNNB1(4), PTK2(3), SRC(4), VCL(1) 3716291 26 23 26 6 17 2 5 1 1 0 0.293 1.000 1.000 238 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(1), DCXR(1), GUSB(1), UGDH(2), UGP2(5), UGT1A1(3), UGT1A3(3), UGT1A5(1), UGT1A6(1), UGT1A9(2), UGT2A1(1), UGT2A3(3), UGT2B10(2), UGT2B28(2), UGT2B4(2), UGT2B7(1), XYLB(5) 5221356 36 26 34 8 20 3 5 5 3 0 0.251 1.000 1.000 239 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(1), ACO2(2), AFMID(2), GRHPR(1), HAO1(1), HAO2(1), HYI(2), MDH1(1), MTHFD1(2), MTHFD1L(2), MTHFD2(2) 2592482 17 16 17 7 6 1 7 1 2 0 0.802 1.000 1.000 240 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(1), JAK1(3), JAK2(2), TYK2(2) 2026709 9 9 9 8 5 0 2 1 1 0 0.988 1.000 1.000 241 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(1), JAK1(3), JAK2(2), TYK2(2) 2026709 9 9 9 8 5 0 2 1 1 0 0.988 1.000 1.000 242 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 12 CHRNG(1), MUSK(2), PIK3R1(2), PTK2(3), PTK2B(3), SRC(4), TERT(1) 2735270 16 14 16 5 8 1 6 0 1 0 0.452 1.000 1.000 243 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(1), POLR2B(1), POLR2C(2), POLR2D(1), POLR2E(1), POLR2F(1), POLRMT(2) 2597919 9 8 9 3 6 0 1 2 0 0 0.668 1.000 1.000 244 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(13), CPT1A(2), LEPR(4), PRKAA2(4), PRKAB2(1), PRKAG1(2) 2805492 26 22 26 9 15 1 5 2 3 0 0.761 1.000 1.000 245 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(3), ADRB2(2), GNAS(4), PLCE1(2), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1) 2857621 18 15 18 8 7 1 6 1 3 0 0.870 1.000 1.000 246 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 EHHADH(1), HADH(1), HADHA(3), HSD17B10(1), HSD17B4(3), SIRT1(1), SIRT5(1), VNN2(2) 2293187 13 12 13 5 10 1 0 1 1 0 0.787 1.000 1.000 247 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(3), EIF2AK4(2), EIF2B5(2), EIF2S3(2), PPP1CA(4) 2232566 13 11 13 6 6 0 3 3 1 0 0.906 1.000 1.000 248 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(6), EGF(4), EGFR(3), HGS(2), RAB5A(1), TFRC(2) 2484220 18 17 18 5 11 0 4 2 1 0 0.617 1.000 1.000 249 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 13 IGF1R(5), IRS1(3), MAP2K1(1), MAPK3(3), PIK3R1(2), RAF1(1), SOS1(5) 3164851 20 18 20 8 10 0 2 5 3 0 0.832 1.000 1.000 250 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CLOCK(1), CRY1(1), CRY2(3), CSNK1E(1), NPAS2(1), NR1D1(3), PER1(3), PER2(1), PER3(3) 3289910 17 15 17 7 6 0 7 1 3 0 0.867 1.000 1.000 251 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 20 CCR3(3), GNAS(4), GNB1(5), LIMK1(2), MAP2K1(1), MAPK3(3), MYL2(2), NOX1(1), PIK3C2G(3), PLCB1(4), PPP1R12B(2), PRKCA(1), PTK2(3), RAF1(1), ROCK2(6) 4759096 41 31 41 9 21 2 4 11 3 0 0.357 1.000 1.000 252 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 12 ARNT(1), HIF1A(1), NOS3(6), P4HB(3) 2326135 11 11 11 8 7 0 1 2 1 0 0.985 1.000 1.000 253 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 14 CSF2RB(1), FOS(3), IL3RA(3), JAK2(2), MAP2K1(1), MAPK3(3), RAF1(1), SOS1(5), STAT5B(2) 3334736 21 19 21 7 13 1 1 3 3 0 0.612 1.000 1.000 254 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(1), B3GNT2(2), B3GNT7(1), B4GALT1(1), CHST2(1), CHST4(2), CHST6(1), FUT8(5), ST3GAL1(1) 2409373 15 15 14 9 8 0 2 4 1 0 0.919 1.000 1.000 255 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(1), CSF1(2), HLA-DRA(1), HLA-DRB1(1), IFNG(1), IL12B(2), IL1A(1), IL6(2), IL7(1), IL8(1), TGFB3(1) 2576046 14 14 14 5 8 0 5 0 1 0 0.513 1.000 1.000 256 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD86(1), HLA-DRA(1), HLA-DRB1(1), IFNG(1), IFNGR2(2), IL12B(2), IL12RB1(2), IL12RB2(1), IL18R1(1), IL2RA(1), IL4R(1) 2447735 14 14 14 5 4 1 8 0 1 0 0.703 1.000 1.000 257 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 14 FOS(3), MAP2K1(1), MAPK3(3), MYC(1), NFKB1(1), NFKBIA(2), PLCB1(4), PRKCA(1), RAF1(1), RELA(2) 2922640 19 17 19 7 7 1 3 6 2 0 0.733 1.000 1.000 258 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(1), AMT(1), ATIC(1), GART(1), MTHFD1(2), MTHFD1L(2), MTHFD2(2), MTHFR(1), MTHFS(1), MTR(3), SHMT1(1), TYMS(1) 3458365 17 14 17 8 7 1 4 2 3 0 0.880 1.000 1.000 259 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA5(1), PSMA6(1), PSMB1(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMC3(2), UBE2A(1), UBE3A(5) 2488114 16 15 16 6 11 0 2 2 1 0 0.763 1.000 1.000 260 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(1), ARSB(2), ARSD(2), ASAH1(2), GAL3ST1(2), GALC(3), GBA(2), GLA(1), GLB1(2), LCT(4), NEU2(2), NEU4(1), PPAP2A(5), PPAP2B(1), PPAP2C(1), SMPD1(3), SMPD2(2), SPTLC1(3), SPTLC2(3), UGCG(1) 4658004 43 34 43 11 24 1 8 4 6 0 0.270 1.000 1.000 261 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 10 KLK2(1), NTRK1(4), PIK3R1(2), PLCG1(3), PRKCA(1), SOS1(5) 2508785 16 15 16 5 9 0 3 3 1 0 0.607 1.000 1.000 262 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 IL2RG(3), IL4R(1), IRS1(3), JAK1(3), JAK3(3), STAT6(3) 2864720 16 13 16 8 9 0 2 3 2 0 0.879 1.000 1.000 263 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 FUCA2(2), GLB1(2), HEXA(1), HEXB(2), LCT(4), MAN2B1(1), MAN2B2(1), MAN2C1(1), MANBA(2), NEU2(2), NEU4(1) 3931006 19 18 19 5 12 1 4 1 1 0 0.390 1.000 1.000 264 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 15 AKT3(1), BPNT1(2), MAPK3(3), PIK3CD(3), PTEN(5), PTK2B(3), RBL2(3), SOS1(5) 3518180 25 20 25 8 17 0 3 2 3 0 0.672 1.000 1.000 265 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 33 ADCY1(3), CALM1(1), CALM2(1), FOS(3), GNAI1(1), GNAS(4), GNB1(5), MAP2K1(1), MAPK3(3), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(1), RAF1(1), RPS6KA3(2), SYT1(2) 6672725 61 41 61 11 29 6 9 9 8 0 0.0793 1.000 1.000 266 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1R(1), C1S(2), C2(1), C3(5), C5(3), C8A(2), C9(5) 3370749 19 17 19 6 7 1 8 1 2 0 0.619 1.000 1.000 267 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(1), F2R(2), F5(9), FGA(7), FGB(1), FGG(3), PROS1(4), SERPINC1(1) 3165429 28 24 28 8 19 1 7 0 1 0 0.551 1.000 1.000 268 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(3), LCT(4), MPI(2), PGM1(2), PYGL(1), PYGM(4), TREH(1) 2587327 17 15 17 8 11 0 3 2 1 0 0.745 1.000 1.000 269 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(1), AMT(1), ATIC(1), GART(1), MTFMT(1), MTHFD1(2), MTHFD1L(2), MTHFD2(2), MTHFR(1), MTHFS(1), MTR(3), SHMT1(1), TYMS(1) 3662369 18 15 18 9 8 1 4 2 3 0 0.912 1.000 1.000 270 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(2), GALNS(1), GLB1(2), GNS(2), GUSB(1), HEXA(1), HEXB(2), HGSNAT(1), HPSE(3), HPSE2(1), HYAL2(2), IDS(1), LCT(4), NAGLU(1), SPAM1(1) 3957115 25 23 25 8 15 1 3 4 2 0 0.481 1.000 1.000 271 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(1), GALNT2(2), GALNT3(1), GALNT4(1), GALNT6(1), GALNT7(1), GALNT8(2), GALNT9(1), GCNT1(1), ST3GAL1(1), WBSCR17(3) 2788109 15 14 15 7 10 1 2 1 1 0 0.832 1.000 1.000 272 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1R(1), C1S(2), C2(1), C3(5), C5(3), C8A(2), C8B(2), C9(5), MASP1(3) 4009297 24 21 24 7 10 1 9 2 2 0 0.521 1.000 1.000 273 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(1), DHRS7(2), DHRSX(3), ESCO1(1), ESCO2(1), MYST3(5), MYST4(3), PNPLA3(2) 3195593 18 16 18 5 8 0 6 2 2 0 0.611 1.000 1.000 274 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1R(1), C1S(2), C2(1), C3(5), C5(3), C8A(2), C9(5), MASP1(3), MASP2(3) 4109416 25 21 25 8 9 1 9 3 3 0 0.616 1.000 1.000 275 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(1), BLVRA(1), CP(1), EPRS(5), FECH(1), GUSB(1), HCCS(1), HMOX2(1), PPOX(4), UGT1A1(3), UGT1A3(3), UGT1A5(1), UGT1A6(1), UGT1A9(2), UGT2B4(2), UROD(1), UROS(2) 5282309 31 23 31 9 14 2 7 2 6 0 0.531 1.000 1.000 276 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 ABP1(3), AOC3(1), DDHD1(2), ESCO1(1), ESCO2(1), LIPA(1), MYST3(5), MYST4(3), PLA1A(2), PNPLA3(2), PPME1(1), PRDX6(4) 4883353 26 22 25 6 14 0 6 4 2 0 0.393 1.000 1.000 277 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(1), ACOT11(4), DHRS1(1), DHRS7(2), DHRSX(3), EHHADH(1), ESCO1(1), ESCO2(1), FN3K(2), GCDH(2), HADHA(3), MYST3(5), MYST4(3), PNPLA3(2), YOD1(1) 5016957 32 28 32 8 20 0 7 2 3 0 0.433 1.000 1.000 278 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(1), ARG2(1), ASL(3), CKMT2(2), CPS1(4), GATM(1), GLUD1(2), ODC1(1), PYCR1(3) 3394201 18 13 18 7 12 0 3 1 2 0 0.700 1.000 1.000 279 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(2), BST1(1), C9orf95(1), CD38(1), ENPP1(2), NADK(2), NADSYN1(3), NNMT(1), NNT(1), NT5C1A(3), NT5C1B(3), NT5C2(2), NT5C3(2), NT5E(3), NUDT12(1), QPRT(2) 4160390 30 23 30 8 17 3 8 2 0 0 0.435 1.000 1.000 280 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 24 CSNK2A1(4), FOS(3), JAK1(3), MAP2K1(1), MAP2K4(1), MAP3K1(3), MAPK3(3), MAPK8(4), PDGFRA(7), PIK3R1(2), PLCG1(3), PRKCA(1), RAF1(1), RASA1(4), SOS1(5), STAT1(4) 6236076 49 40 49 10 24 2 10 8 5 0 0.155 1.000 1.000 281 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 20 CSNK2A1(4), FOS(3), JAK2(2), MAP2K1(1), MAPK3(3), MPL(1), PIK3R1(2), PLCG1(3), PRKCA(1), RAF1(1), RASA1(4), SOS1(5), STAT1(4), STAT5B(2), THPO(1) 5280857 37 29 37 9 21 2 4 6 4 0 0.354 1.000 1.000 282 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(1), CALM2(1), CHUK(6), EGR2(1), EGR3(1), MAP3K1(3), MYC(1), NFATC1(4), NFATC2(6), NFKB1(1), NFKBIA(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), RELA(2), SYT1(2), VIPR2(4) 5399164 55 39 55 13 24 5 10 4 12 0 0.270 1.000 1.000 283 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(3), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH3B1(2), ALDH9A1(2), AOC3(1), ASPA(2), CNDP1(1), DDC(3), HAL(3), HDC(2), HNMT(1), MAOA(1) 4712282 26 24 26 8 11 0 8 3 4 0 0.466 1.000 1.000 284 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 15 MAPK3(3), MAPK7(2), MEF2A(1), MEF2C(2), MEF2D(1), NTRK1(4), PIK3R1(2), PLCG1(3), RPS6KA1(1) 3159320 19 17 19 9 8 0 8 2 1 0 0.833 1.000 1.000 285 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), CA12(1), CA4(1), CPS1(4), CTH(2), GLS(1), GLS2(1), GLUD1(2), HAL(3) 3668549 16 10 16 8 8 1 5 0 2 0 0.899 1.000 1.000 286 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(1), DCXR(1), GUSB(1), UCHL1(1), UGDH(2), UGT1A1(3), UGT1A3(3), UGT1A5(1), UGT1A6(1), UGT1A9(2), UGT2B4(2) 3378842 18 14 18 7 9 2 4 2 1 0 0.712 1.000 1.000 287 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(5), POLR1B(1), POLR1C(1), POLR1D(2), POLR2B(1), POLR2C(2), POLR2D(1), POLR2E(1), POLR2F(1), POLR3A(5), POLR3B(3), POLR3H(1) 4534686 24 18 24 8 13 1 4 3 3 0 0.672 1.000 1.000 288 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG3(1), ATG5(1), ATG7(1), BECN1(2), GABARAP(1), IFNA16(1), IFNA4(3), IFNG(1), PIK3C3(5), PIK3R4(3), PRKAA2(4), ULK1(3), ULK2(5) 4047642 31 23 31 9 18 2 8 3 0 0 0.549 1.000 1.000 289 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 CTH(2), DNMT1(4), DNMT3A(1), DNMT3B(1), MAT1A(2), MTFMT(1), MTR(3), SRM(2) 4005994 16 14 16 5 8 2 3 1 2 0 0.542 1.000 1.000 290 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(4), ALDH3A1(2), ALDH9A1(2), CYP2C19(1), CYP2C9(2), DHRS1(1), DHRS7(2), DHRSX(3), EHHADH(1), ESCO1(1), ESCO2(1), HADHA(3), MYST3(5), MYST4(3), PNPLA3(2), YOD1(1) 5968722 34 29 34 8 20 0 8 2 4 0 0.277 1.000 1.000 291 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(2), FBP1(1), MDH1(1), ME1(2), ME3(1), PKLR(1), PKM2(2), RPIA(2), TKTL1(3), TKTL2(1) 3902271 16 13 16 8 10 0 3 1 2 0 0.785 1.000 1.000 292 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(2), FBP1(1), MDH1(1), ME1(2), ME2(1), ME3(1), PKLR(1), PKM2(2), RPIA(2) 3489668 13 10 13 5 8 0 3 1 1 0 0.644 1.000 1.000 293 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(1), ACAD9(1), ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), DHRS1(1), DHRS7(2), DHRSX(3), ESCO1(1), ESCO2(1), MYST3(5), MYST4(3), PNPLA3(2) 4817399 28 24 28 7 15 0 8 3 2 0 0.423 1.000 1.000 294 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(2), FBP1(1), GPI(3), H6PD(5), PFKP(1), PGD(1), PGM1(2), RBKS(1), RPIA(2) 3959552 18 17 18 8 7 0 8 1 2 0 0.704 1.000 1.000 295 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(4), ACTB(5), ACTG1(4), ARHGEF2(2), ARPC5(1), CDH1(6), CLDN1(1), CTNNB1(4), CTTN(2), EZR(6), FYN(1), HCLS1(1), ITGB1(1), KRT18(3), LY96(1), NCK1(1), NCL(1), OCLN(3), PRKCA(1), ROCK1(4), ROCK2(6), TLR4(3), TLR5(5), TUBA1A(2), TUBA1C(1), TUBA3C(3), TUBA3D(2), TUBA3E(1), TUBA8(1), TUBAL3(1), TUBB(1), TUBB2C(1), TUBB3(5), TUBB4(2), TUBB6(2), TUBB8(2), WAS(1), WASL(1), YWHAQ(1), YWHAZ(3) 10064691 96 61 95 18 56 1 14 12 13 0 0.0463 1.000 1.000 296 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(4), ACTB(5), ACTG1(4), ARHGEF2(2), ARPC5(1), CDH1(6), CLDN1(1), CTNNB1(4), CTTN(2), EZR(6), FYN(1), HCLS1(1), ITGB1(1), KRT18(3), LY96(1), NCK1(1), NCL(1), OCLN(3), PRKCA(1), ROCK1(4), ROCK2(6), TLR4(3), TLR5(5), TUBA1A(2), TUBA1C(1), TUBA3C(3), TUBA3D(2), TUBA3E(1), TUBA8(1), TUBAL3(1), TUBB(1), TUBB2C(1), TUBB3(5), TUBB4(2), TUBB6(2), TUBB8(2), WAS(1), WASL(1), YWHAQ(1), YWHAZ(3) 10064691 96 61 95 18 56 1 14 12 13 0 0.0463 1.000 1.000 297 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 14 CREBBP(18), FYN(1), IL2RG(3), IL7(1), IL7R(2), JAK1(3), JAK3(3), LCK(1), PIK3R1(2), PTK2B(3), STAT5B(2) 4017577 39 35 38 11 17 0 11 3 8 0 0.364 1.000 1.000 298 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(3), ALDH3A1(2), ALDH3B1(2), AOC3(1), DDC(3), EPX(2), ESCO1(1), ESCO2(1), HPD(2), LPO(4), MAOA(1), MPO(2), MYST3(5), MYST4(3), PNPLA3(2), PRDX6(4), TPO(9) 6602111 47 37 46 10 23 0 15 5 4 0 0.136 1.000 1.000 299 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 ALOX15(2), ALOX5(2), CYP4F2(4), CYP4F3(2), EPX(2), GGT1(1), LPO(4), LTA4H(1), MPO(2), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), PRDX1(2), PRDX2(4), PRDX5(1), PRDX6(4), PTGES2(2), PTGIS(1), PTGS2(2), TBXAS1(3), TPO(9) 5401593 56 41 55 17 28 0 14 5 9 0 0.286 1.000 1.000 300 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 21 ADCY1(3), ASAH1(2), GNAI1(1), GNB1(5), ITGAV(3), ITGB3(2), MAPK3(3), PDGFRA(7), PIK3R1(2), PLCB1(4), PRKCA(1), PTK2(3), RAC1(1), SMPD1(3), SMPD2(2), SRC(4) 4884940 46 35 46 12 21 2 12 7 4 0 0.365 1.000 1.000 301 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 24 CSNK2A1(4), EGF(4), EGFR(3), FOS(3), JAK1(3), MAP2K1(1), MAP2K4(1), MAP3K1(3), MAPK3(3), MAPK8(4), PIK3R1(2), PLCG1(3), PRKCA(1), RAF1(1), RASA1(4), SOS1(5), STAT1(4) 6731213 49 39 49 11 25 2 9 8 5 0 0.235 1.000 1.000 302 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(3), ACY1(1), ADC(1), ALDH3A1(2), ALDH9A1(2), AOC3(1), ARG2(1), ASL(3), ASS1(2), CPS1(4), GATM(1), MAOA(1), ODC1(1), SAT2(1), SRM(2) 5688955 26 21 26 8 14 1 6 2 3 0 0.409 1.000 1.000 303 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT3(1), ANKRD6(3), APC(7), AXIN1(3), AXIN2(4), CER1(2), CSNK1A1(3), CTNNB1(4), DACT1(2), DKK1(1), DKK2(3), DKK3(3), DKK4(1), FSTL1(1), GSK3A(1), LRP1(12), MVP(4), PSEN1(5), PTPRA(1), WIF1(2) 7815319 63 47 62 13 28 3 15 5 12 0 0.157 1.000 1.000 304 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 21 CDK5(1), CDK5R1(1), CHN1(3), LIMK1(2), MAP3K1(3), MYL2(2), MYLK(5), NCF2(4), PDGFRA(7), PIK3R1(2), PLD1(3), PPP1R12B(2), RAC1(1), RALBP1(1), TRIO(13), VAV1(2) 6330657 52 40 52 12 24 1 14 5 8 0 0.272 1.000 1.000 305 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(1), ACAA2(1), ACADSB(1), ACAT1(1), ACOX1(1), ACOX3(3), ACSL1(1), ACSL5(1), ACSL6(2), ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), ALDH3A1(2), ALDH9A1(2), CPT1A(2), CPT1B(2), CPT1C(2), CYP4A11(2), CYP4A22(4), EHHADH(1), GCDH(2), HADH(1), HADHA(3), HADHB(2), HSD17B10(1), HSD17B4(3), PECI(3) 9463608 52 40 52 12 36 1 6 4 5 0 0.124 1.000 1.000 306 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 33 BLNK(1), BTK(3), CALM1(1), CALM2(1), CD79A(1), CD79B(1), FOS(3), LYN(2), MAP2K1(1), MAP3K1(3), MAPK14(1), MAPK3(3), MAPK8(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKCA(1), RAC1(1), RAF1(1), SOS1(5), SYK(1), SYT1(2), VAV1(2) 7305896 64 48 64 15 32 3 10 11 8 0 0.266 1.000 1.000 307 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 46 ACOX1(1), APOA2(1), CD36(1), CITED2(1), CPT1B(2), CREBBP(18), DUT(1), EHHADH(1), HSD17B4(3), HSPA1A(2), LPL(1), MAPK3(3), ME1(2), MRPL11(1), MYC(1), NCOA1(10), NCOR1(13), NCOR2(10), NFKBIA(2), NR2F1(2), NRIP1(4), PIK3R1(2), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(1), PTGS2(2), RELA(2), SP1(3), STAT5B(2) 10321882 99 61 98 23 41 2 24 11 21 0 0.125 1.000 1.000 308 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(1), ARSD(2), ASAH1(2), B4GALT6(2), GAL3ST1(2), GALC(3), GBA(2), GLA(1), GLB1(2), LCT(4), NEU2(2), NEU4(1), PPAP2A(5), PPAP2B(1), PPAP2C(1), SGMS2(1), SMPD1(3), SMPD2(2), SMPD3(1), SMPD4(3), SPHK2(4), SPTLC1(3), SPTLC2(3), UGCG(1), UGT8(2) 6902767 54 39 54 16 26 1 13 5 9 0 0.325 1.000 1.000 309 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 188 ACTB(5), ACTG1(4), ACTN1(2), ACTN2(3), ACTN3(2), ACTN4(4), AKT3(1), ARHGAP5(8), BIRC3(1), BRAF(1), CAV2(1), CCND1(1), COL11A1(10), COL11A2(3), COL1A1(2), COL1A2(4), COL2A1(4), COL4A1(3), COL4A2(5), COL4A4(4), COL4A6(1), COL5A1(8), COL5A2(5), COL5A3(3), COL6A2(1), COL6A3(10), COL6A6(10), COMP(5), CTNNB1(4), DIAPH1(2), DOCK1(4), EGF(4), EGFR(3), ERBB2(11), FARP2(2), FIGF(1), FLNA(5), FLNB(6), FLNC(5), FLT1(1), FN1(6), FYN(1), GRLF1(14), HGF(1), IBSP(1), IGF1R(5), ITGA1(1), ITGA10(1), ITGA11(4), ITGA2(3), ITGA2B(7), ITGA3(4), ITGA4(6), ITGA5(3), ITGA6(2), ITGA7(2), ITGA8(5), ITGA9(3), ITGAV(3), ITGB1(1), ITGB3(2), ITGB4(5), ITGB5(2), ITGB8(1), KDR(9), LAMA1(6), LAMA2(14), LAMA3(17), LAMA4(5), LAMA5(8), LAMB1(5), LAMB2(4), LAMB3(3), LAMB4(3), LAMC1(5), LAMC2(2), LAMC3(4), MAP2K1(1), MAPK10(1), MAPK3(3), MAPK8(4), MAPK9(5), MET(5), MYL2(2), MYLK(5), MYLK2(4), MYLPF(1), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PAK7(2), PARVB(2), PDGFB(1), PDGFRA(7), PDGFRB(4), PDPK1(1), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIP5K1C(2), PPP1CA(4), PPP1CB(3), PPP1R12A(4), PRKCA(1), PRKCG(2), PTEN(5), PTK2(3), RAC1(1), RAF1(1), RAP1A(1), RAP1B(2), RELN(13), ROCK1(4), ROCK2(6), SHC2(1), SHC4(4), SOS1(5), SOS2(4), SPP1(1), SRC(4), THBS2(6), THBS3(2), THBS4(2), TLN1(2), TLN2(5), TNC(5), TNN(2), TNR(7), TNXB(11), VAV1(2), VAV2(1), VAV3(2), VCL(1), VEGFB(2), VEGFC(1), VTN(2), VWF(7), ZYX(1) 71042899 528 116 524 197 265 16 119 65 63 0 0.995 1.000 1.000 310 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 199 ABI2(2), ACTN1(2), ACTN2(3), ACTN3(2), ACTN4(4), APC(7), APC2(3), ARAF(1), ARHGEF1(6), ARHGEF12(4), ARHGEF4(2), ARHGEF6(2), ARHGEF7(3), ARPC2(3), ARPC4(1), ARPC5(1), BDKRB1(1), BRAF(1), CFL2(1), CHRM1(1), CHRM3(4), CHRM4(1), CSK(4), CYFIP1(4), CYFIP2(1), DIAPH1(2), DIAPH2(4), DIAPH3(4), DOCK1(4), EGF(4), EGFR(3), EZR(6), F2R(2), FGD1(4), FGF1(1), FGF10(1), FGF12(1), FGF13(3), FGF14(1), FGF17(1), FGF3(2), FGF6(1), FGF8(2), FGFR1(3), FGFR2(4), FGFR4(3), FN1(6), GIT1(2), GNA13(5), GRLF1(14), IQGAP1(3), IQGAP2(1), IQGAP3(5), ITGA1(1), ITGA10(1), ITGA11(4), ITGA2(3), ITGA2B(7), ITGA3(4), ITGA4(6), ITGA5(3), ITGA6(2), ITGA7(2), ITGA8(5), ITGA9(3), ITGAD(2), ITGAE(3), ITGAL(2), ITGAM(3), ITGAV(3), ITGB1(1), ITGB2(3), ITGB3(2), ITGB4(5), ITGB5(2), ITGB8(1), LIMK1(2), MAP2K1(1), MAPK3(3), MOS(2), MYH10(7), MYH14(1), MYH9(13), MYL2(2), MYLK(5), MYLK2(4), MYLPF(1), NCKAP1(5), NCKAP1L(4), NRAS(2), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PAK7(2), PDGFB(1), PDGFRA(7), PDGFRB(4), PFN1(2), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIP4K2A(2), PIP4K2B(1), PIP4K2C(3), PIP5K1A(5), PIP5K1C(2), PPP1CA(4), PPP1CB(3), PPP1R12A(4), PPP1R12B(2), PTK2(3), RAC1(1), RAF1(1), RDX(2), ROCK1(4), ROCK2(6), RRAS(1), SCIN(1), SLC9A1(1), SOS1(5), SOS2(4), SSH1(2), SSH2(6), SSH3(4), TIAM1(7), TIAM2(6), VAV1(2), VAV2(1), VAV3(2), VCL(1), WAS(1), WASF2(3), WASL(1) 52562213 404 115 403 125 209 7 92 49 47 0 0.451 1.000 1.000 311 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 244 ACVR1B(1), ACVR1C(1), AKT3(1), ARRB1(1), BDNF(1), BRAF(1), CACNA1A(6), CACNA1B(2), CACNA1C(5), CACNA1D(5), CACNA1E(4), CACNA1F(4), CACNA1G(6), CACNA1H(1), CACNA1I(4), CACNA1S(5), CACNA2D1(5), CACNA2D2(3), CACNA2D3(1), CACNA2D4(1), CACNB1(2), CACNB2(2), CACNB4(1), CACNG2(1), CACNG3(1), CACNG4(1), CACNG5(1), CACNG6(2), CACNG7(1), CACNG8(1), CASP3(1), CHUK(6), DAXX(1), DUSP10(3), DUSP14(2), DUSP16(4), DUSP2(1), DUSP4(1), DUSP6(3), DUSP7(3), DUSP8(3), ECSIT(1), EGF(4), EGFR(3), ELK4(1), FGF1(1), FGF10(1), FGF12(1), FGF13(3), FGF14(1), FGF17(1), FGF3(2), FGF6(1), FGF8(2), FGFR1(3), FGFR2(4), FGFR4(3), FLNA(5), FLNB(6), FLNC(5), FOS(3), GADD45A(1), IKBKB(4), IL1A(1), IL1B(1), JUND(1), MAP2K1(1), MAP2K3(2), MAP2K4(1), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K12(1), MAP3K13(6), MAP3K14(2), MAP3K2(2), MAP3K4(5), MAP3K5(4), MAP3K6(3), MAP3K7(3), MAP3K8(2), MAP4K1(3), MAP4K2(4), MAP4K3(4), MAP4K4(2), MAPK10(1), MAPK11(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK7(2), MAPK8(4), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(3), MAPK9(5), MAPKAPK2(1), MAPT(5), MEF2C(2), MKNK1(1), MOS(2), MYC(1), NF1(13), NFATC2(6), NFATC4(1), NFKB1(1), NFKB2(1), NLK(2), NR4A1(1), NRAS(2), NTF3(1), NTRK1(4), NTRK2(4), PAK2(1), PDGFB(1), PDGFRA(7), PDGFRB(4), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), PPM1A(3), PPM1B(2), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(2), PPP5C(1), PRKACB(1), PRKCA(1), PRKCG(2), PRKX(1), PTPN7(1), PTPRR(1), RAC1(1), RAF1(1), RAP1A(1), RAP1B(2), RAPGEF2(6), RASA1(4), RASA2(1), RASGRF1(2), RASGRF2(2), RASGRP1(1), RASGRP2(2), RASGRP3(2), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), RPS6KA4(1), RPS6KA5(3), RPS6KA6(2), RRAS(1), SOS1(5), SOS2(4), STK3(2), STK4(3), TAOK1(2), TAOK2(5), TAOK3(2), TGFB3(1), TGFBR2(3), TRAF2(2), TRAF6(1), ZAK(1) 54704266 400 109 400 149 174 18 103 49 56 0 0.927 1.000 1.000 312 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(5), ACTG1(4), COL11A1(10), COL11A2(3), COL17A1(2), COL1A1(2), COL1A2(4), COL2A1(4), COL4A1(3), COL4A2(5), COL4A4(4), COL4A6(1), COL5A1(8), COL5A2(5), COL5A3(3), COL6A2(1), COL6A3(10), COL6A6(10), COMP(5), DSC1(4), DSC2(2), DSC3(2), DSG1(7), DSG2(5), DSG3(1), DSG4(1), FN1(6), GJA1(1), GJA10(2), GJA9(2), GJC1(1), GJD2(2), IBSP(1), INA(1), ITGA6(2), ITGB4(5), KRT12(2), KRT13(1), KRT14(1), KRT15(3), KRT16(1), KRT17(1), KRT18(3), KRT2(1), KRT20(1), KRT24(1), KRT25(1), KRT28(1), KRT3(1), KRT31(1), KRT32(1), KRT33A(1), KRT33B(1), KRT34(1), KRT35(1), KRT36(2), KRT37(1), KRT38(2), KRT39(2), KRT4(2), KRT40(1), KRT6A(2), KRT6B(3), KRT6C(3), KRT7(2), KRT71(2), KRT72(1), KRT73(1), KRT74(1), KRT75(2), KRT76(1), KRT78(1), KRT79(3), KRT8(1), KRT82(1), KRT83(2), KRT84(4), KRT85(1), KRT9(1), LAMA1(6), LAMA2(14), LAMA3(17), LAMA4(5), LAMA5(8), LAMB1(5), LAMB2(4), LAMB3(3), LAMB4(3), LAMC1(5), LAMC2(2), LAMC3(4), LMNA(1), LMNB1(2), LMNB2(1), NES(8), PRPH(2), RELN(13), SPP1(1), THBS2(6), THBS3(2), THBS4(2), TNC(5), TNN(2), TNR(7), TNXB(11), VIM(2), VTN(2), VWF(7) 48145810 350 106 347 146 184 16 79 39 32 0 0.999 1.000 1.000 313 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 167 ADCY1(3), ADCY2(10), ADCY3(2), ADCY4(2), ADCY7(1), ADCY8(5), ADCY9(3), ADRA1A(4), ADRA1B(1), ADRA1D(2), ADRB1(1), ADRB2(2), ATP2A1(6), ATP2A2(2), ATP2A3(2), ATP2B1(5), ATP2B2(5), ATP2B3(1), ATP2B4(5), AVPR1A(1), AVPR1B(1), BDKRB1(1), BST1(1), CACNA1A(6), CACNA1B(2), CACNA1C(5), CACNA1D(5), CACNA1E(4), CACNA1F(4), CACNA1G(6), CACNA1H(1), CACNA1I(4), CACNA1S(5), CALM1(1), CALM2(1), CALML3(1), CALML6(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), CAMK4(1), CCKBR(3), CD38(1), CHRM1(1), CHRM3(4), CYSLTR2(1), EDNRA(1), EDNRB(2), EGFR(3), ERBB2(11), ERBB4(3), F2R(2), GNA14(2), GNA15(1), GNAL(1), GNAS(4), GRIN1(6), GRIN2A(9), GRIN2C(5), GRIN2D(2), GRM1(7), GRM5(5), HRH1(4), HTR2B(2), HTR2C(1), HTR4(2), HTR6(1), HTR7(1), ITPKA(2), ITPKB(1), ITPR1(7), ITPR2(9), ITPR3(4), LHCGR(2), LTB4R2(2), MYLK(5), MYLK2(4), NOS1(4), NOS3(6), NTSR1(1), OXTR(1), P2RX1(2), P2RX2(1), P2RX3(2), P2RX7(1), PDE1A(2), PDE1C(4), PDGFRA(7), PDGFRB(4), PHKA1(5), PHKA2(1), PHKB(1), PHKG2(2), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PLCD1(1), PLCD3(1), PLCD4(2), PLCE1(2), PLCG1(3), PLCG2(3), PLCZ1(2), PLN(1), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(2), PRKACB(1), PRKCA(1), PRKCG(2), PRKX(1), PTAFR(1), PTGER3(1), PTGFR(2), PTK2B(3), RYR1(12), RYR2(21), RYR3(14), SLC25A4(1), SLC25A6(1), SLC8A1(2), SLC8A2(2), SLC8A3(2), SPHK2(4), TACR1(2), TACR3(1), TRHR(2), TRPC1(2), VDAC1(1), VDAC2(2) 51394057 406 106 404 176 186 13 128 46 33 0 0.951 1.000 1.000 314 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(2), ADORA1(1), ADRA1A(4), ADRA1B(1), ADRA2C(1), ADRB1(1), ADRB2(2), AGTR2(1), AVPR1A(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BRS3(1), CALCR(2), CALCRL(2), CCKBR(3), CHRM1(1), CHRM3(4), CHRM4(1), CNR1(1), CNR2(3), CRHR2(1), CTSG(3), CYSLTR2(1), DRD3(1), EDNRA(1), EDNRB(2), F2R(2), F2RL1(3), F2RL3(1), FPR1(1), FSHR(1), GABBR1(2), GABBR2(3), GABRA1(1), GABRA2(1), GABRA3(1), GABRA4(5), GABRA5(3), GABRA6(3), GABRB1(2), GABRB2(3), GABRB3(2), GABRE(1), GABRG1(5), GABRG2(2), GABRG3(2), GABRP(1), GABRR1(2), GABRR2(1), GALR1(1), GALR2(3), GALR3(1), GHR(2), GHRHR(1), GHSR(1), GIPR(1), GLP2R(1), GLRA1(1), GLRA2(1), GLRA3(2), GLRB(2), GPR156(2), GPR50(5), GPR63(2), GPR83(1), GRIA1(3), GRIA2(3), GRIA3(2), GRIA4(5), GRID1(2), GRID2(2), GRIK1(7), GRIK2(4), GRIK3(4), GRIK4(2), GRIK5(2), GRIN1(6), GRIN2A(9), GRIN2B(3), GRIN2C(5), GRIN2D(2), GRIN3A(2), GRM1(7), GRM2(5), GRM3(3), GRM4(1), GRM5(5), GRM6(4), GRM7(4), GRM8(1), GZMA(4), HCRTR2(2), HRH1(4), HRH4(1), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(1), HTR1F(1), HTR2B(2), HTR2C(1), HTR4(2), HTR6(1), HTR7(1), LEPR(4), LHCGR(2), LTB4R2(2), MC3R(1), MC4R(2), MCHR2(1), MLNR(1), MTNR1A(1), NMBR(3), NPBWR2(1), NPFFR1(2), NPFFR2(3), NPY1R(1), NPY5R(4), NR3C1(1), NTSR1(1), OPRD1(2), OXTR(1), P2RX1(2), P2RX2(1), P2RX3(2), P2RX7(1), P2RY1(1), P2RY10(1), P2RY13(2), P2RY2(1), PARD3(6), PRL(2), PRLR(1), PTAFR(1), PTGDR(3), PTGER2(1), PTGER3(1), PTGER4(2), PTGFR(2), PTGIR(1), PTH2R(2), RXFP1(2), RXFP2(2), SCTR(3), SSTR1(1), SSTR3(2), SSTR4(3), TAAR5(1), TAAR8(3), TAAR9(1), TACR1(2), TACR3(1), TRHR(2), TRPV1(2), TSHR(2), UTS2R(1), VIPR1(1), VIPR2(4) 42744573 335 105 334 162 156 13 98 32 36 0 0.958 1.000 1.000 315 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(3), CD36(1), CD47(1), COL11A1(10), COL11A2(3), COL1A1(2), COL1A2(4), COL2A1(4), COL4A1(3), COL4A2(5), COL4A4(4), COL4A6(1), COL5A1(8), COL5A2(5), COL5A3(3), COL6A2(1), COL6A3(10), COL6A6(10), DAG1(1), FN1(6), FNDC1(8), FNDC3A(6), GP5(1), GP6(1), HSPG2(8), IBSP(1), ITGA1(1), ITGA10(1), ITGA11(4), ITGA2(3), ITGA2B(7), ITGA3(4), ITGA4(6), ITGA5(3), ITGA6(2), ITGA7(2), ITGA8(5), ITGA9(3), ITGAV(3), ITGB1(1), ITGB3(2), ITGB4(5), ITGB5(2), ITGB8(1), LAMA1(6), LAMA2(14), LAMA3(17), LAMA4(5), LAMA5(8), LAMB1(5), LAMB2(4), LAMB3(3), LAMB4(3), LAMC1(5), LAMC2(2), LAMC3(4), RELN(13), SDC1(2), SDC3(1), SPP1(1), SV2A(2), SV2B(5), SV2C(1), THBS2(6), THBS3(2), THBS4(2), TNC(5), TNN(2), TNR(7), TNXB(11), VTN(2), VWF(7) 43348280 310 104 308 119 157 12 70 35 36 0 0.994 1.000 1.000 316 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 129 ACTB(5), ACTG1(4), ACTN1(2), ACTN2(3), ACTN3(2), ACTN4(4), AKT3(1), AMOTL1(6), ASH1L(13), CASK(1), CDK4(2), CGN(2), CLDN1(1), CLDN10(1), CLDN17(2), CLDN19(1), CLDN2(1), CLDN23(1), CLDN4(1), CLDN5(1), CLDN6(1), CLDN8(1), CSDA(1), CSNK2A1(4), CSNK2B(2), CTNNA1(1), CTNNA2(2), CTNNA3(3), CTNNB1(4), CTTN(2), EPB41(5), EPB41L1(4), EPB41L3(6), EXOC3(2), EXOC4(5), F11R(1), GNAI1(1), GNAI3(2), HCLS1(1), IGSF5(2), INADL(5), JAM2(1), JAM3(1), LLGL1(1), LLGL2(1), MAGI1(4), MAGI2(7), MAGI3(7), MLLT4(3), MPDZ(12), MPP5(2), MYH1(5), MYH10(7), MYH11(4), MYH13(6), MYH14(1), MYH15(6), MYH2(5), MYH3(7), MYH4(5), MYH6(3), MYH7(8), MYH7B(6), MYH8(3), MYH9(13), MYL2(2), MYLPF(1), NRAS(2), OCLN(3), PARD3(6), PARD6A(3), PARD6B(1), PARD6G(1), PPM1J(1), PPP2CA(1), PPP2R1A(1), PPP2R1B(3), PPP2R2B(1), PPP2R2C(1), PPP2R3A(7), PRKCA(1), PRKCD(1), PRKCG(2), PRKCI(1), PRKCQ(1), PRKCZ(2), PTEN(5), RAB3B(1), RRAS(1), SPTAN1(34), SRC(4), SYMPK(4), TJAP1(1), TJP1(3), TJP2(5), VAPA(2), YES1(1), ZAK(1) 37332296 331 102 330 107 183 18 51 26 53 0 0.750 1.000 1.000 317 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1B(1), ACVR2A(2), AMHR2(1), BMPR1A(1), BMPR1B(2), BMPR2(5), CCL1(3), CCL13(1), CCL14(1), CCL15(1), CCL16(1), CCL21(1), CCL23(1), CCL25(1), CCL3(1), CCR1(1), CCR3(3), CCR4(2), CCR5(2), CCR7(3), CCR8(1), CD27(1), CD40(1), CLCF1(2), CNTF(1), CNTFR(1), CSF1(2), CSF1R(6), CSF2RA(1), CSF2RB(1), CSF3R(2), CX3CL1(5), CX3CR1(3), CXCL11(1), CXCL13(1), CXCL14(1), CXCL5(1), CXCL6(1), CXCR3(1), CXCR4(2), EDA(1), EGF(4), EGFR(3), EPOR(1), FLT1(1), FLT3(3), FLT4(1), GDF5(1), GHR(2), HGF(1), IFNA16(1), IFNA4(3), IFNAR1(1), IFNAR2(1), IFNG(1), IFNGR2(2), IL10RA(4), IL10RB(3), IL12B(2), IL12RB1(2), IL12RB2(1), IL13RA1(1), IL17A(1), IL17B(3), IL17RA(1), IL18R1(1), IL18RAP(6), IL19(2), IL1A(1), IL1B(1), IL1RAP(1), IL20RA(1), IL21(1), IL21R(5), IL22RA1(1), IL23A(1), IL23R(4), IL24(1), IL26(1), IL28A(1), IL28B(1), IL28RA(1), IL2RA(1), IL2RB(2), IL2RG(3), IL3RA(3), IL4R(1), IL5RA(2), IL6(2), IL6R(1), IL6ST(3), IL7(1), IL7R(2), IL8(1), IL9R(1), INHBB(1), INHBE(2), KDR(9), KIT(3), KITLG(2), LEPR(4), LIFR(3), MET(5), MPL(1), NGFR(3), OSM(2), OSMR(3), PDGFB(1), PDGFRA(7), PDGFRB(4), PLEKHO2(3), PPBP(2), PRL(2), PRLR(1), TGFB3(1), TGFBR2(3), TNFRSF10A(4), TNFRSF10C(1), TNFRSF10D(1), TNFRSF13C(1), TNFRSF1B(3), TNFRSF21(3), TNFRSF25(3), TNFRSF4(1), TNFRSF8(4), TNFRSF9(2), TNFSF10(2), TNFSF11(1), TNFSF13B(3), TNFSF14(1), TNFSF4(1), TNFSF8(3), TPO(9), VEGFB(2), VEGFC(1) 34218925 275 101 274 100 133 5 72 35 30 0 0.789 1.000 1.000 318 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(3), ACTA2(3), ACTN2(3), ACTN3(2), ACTN4(4), DMD(7), FAM48A(2), MYBPC1(5), MYBPC2(2), MYBPC3(2), MYH3(7), MYH6(3), MYH7(8), MYH8(3), MYL2(2), MYOM1(5), NEB(15), TCAP(1), TMOD1(1), TNNI1(2), TNNI2(1), TNNI3(1), TNNT1(3), TPM1(1), TPM2(2), TTN(140), VIM(2) 25820783 230 101 230 60 113 8 57 36 16 0 0.356 1.000 1.000 319 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 125 ABL1(4), ABLIM1(3), ABLIM2(1), ABLIM3(1), ARHGEF12(4), CDK5(1), CFL2(1), CXCR4(2), DCC(8), DPYSL2(1), EFNA5(1), EFNB1(1), EFNB2(1), EFNB3(1), EPHA1(3), EPHA2(8), EPHA3(1), EPHA5(5), EPHA6(3), EPHA7(2), EPHA8(3), EPHB1(4), EPHB2(3), EPHB3(1), EPHB4(3), EPHB6(3), FES(1), FYN(1), GNAI1(1), GNAI3(2), ITGB1(1), L1CAM(2), LIMK1(2), LRRC4C(1), MAPK3(3), MET(5), NCK1(1), NFAT5(7), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), NGEF(1), NRAS(2), NRP1(2), NTN1(4), NTN4(1), NTNG1(3), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PAK7(2), PLXNA1(1), PLXNA2(2), PLXNB1(1), PLXNB2(8), PLXNB3(3), PLXNC1(2), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(2), PTK2(3), RAC1(1), RASA1(4), RGS3(1), RND1(2), ROBO1(6), ROBO2(6), ROBO3(2), ROCK1(4), ROCK2(6), SEMA3A(6), SEMA3B(2), SEMA3C(2), SEMA3D(7), SEMA3E(1), SEMA3F(3), SEMA3G(2), SEMA4A(3), SEMA4B(3), SEMA4C(1), SEMA4D(1), SEMA4F(2), SEMA4G(1), SEMA5A(6), SEMA5B(7), SEMA6B(2), SEMA6C(6), SEMA6D(4), SLIT1(2), SLIT3(4), SRGAP1(1), SRGAP2(3), SRGAP3(1), UNC5A(3), UNC5B(1), UNC5C(2), UNC5D(3) 37894655 275 97 275 102 132 10 70 34 29 0 0.873 1.000 1.000 320 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(3), ADCY2(10), ADCY3(2), ADCY4(2), ADCY5(1), ADCY6(4), ADCY7(1), ADCY8(5), ADCY9(3), ADRA1A(4), ADRA1B(1), ADRA1D(2), ADRB1(1), ADRB2(2), ANXA6(3), ARRB1(1), ATP1A4(5), ATP1B2(3), ATP2A2(2), ATP2A3(2), ATP2B1(5), ATP2B2(5), ATP2B3(1), CACNA1A(6), CACNA1B(2), CACNA1C(5), CACNA1D(5), CACNA1E(4), CACNA1S(5), CACNB1(2), CALM1(1), CALM2(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), CAMK4(1), CASQ1(2), CASQ2(1), CHRM1(1), CHRM3(4), CHRM4(1), GJA1(1), GNAI3(2), GNAO1(2), GNAZ(1), GNB1(5), GNB3(3), GNB4(1), GNB5(2), GNG2(1), GNG4(4), GRK5(2), GRK6(1), ITPR1(7), ITPR2(9), ITPR3(4), KCNB1(3), KCNJ3(1), KCNJ5(1), MIB1(4), NME7(1), PKIA(1), PKIG(1), PLCB3(6), PLN(1), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(1), PRKCD(1), PRKCG(2), PRKCQ(1), PRKCZ(2), PRKD1(2), RGS10(1), RGS14(2), RGS16(3), RGS18(2), RGS19(1), RGS2(1), RGS3(1), RGS4(1), RGS5(2), RGS6(1), RGS7(4), RGS9(1), RYR1(12), RYR2(21), RYR3(14), SFN(1), SLC8A1(2), SLC8A3(2), USP5(1), YWHAB(2), YWHAQ(1) 36164884 271 96 270 127 129 13 76 30 23 0 0.987 1.000 1.000 321 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(3), ACTA2(3), ADCY1(3), ADCY2(10), ADCY3(2), ADCY4(2), ADCY5(1), ADCY6(4), ADCY7(1), ADCY8(5), ADCY9(3), ADM(3), ARRB1(1), ATF1(1), ATP2A2(2), ATP2A3(2), CALM1(1), CALM2(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), CNN1(2), CNN2(2), DGKZ(3), FOS(3), GABPA(4), GJA1(1), GNB1(5), GNB3(3), GNB4(1), GNB5(2), GNG2(1), GNG4(4), GRK5(2), GRK6(1), GSTO1(1), GUCY1A3(6), IL1B(1), IL6(2), ITPR1(7), ITPR2(9), ITPR3(4), MAFF(1), MIB1(4), MYL2(2), MYLK2(4), NFKB1(1), NOS1(4), NOS3(6), OXTR(1), PDE4B(1), PDE4D(2), PKIA(1), PKIG(1), PLCB3(6), PLCD1(1), PLCG1(3), PLCG2(3), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(1), PRKCD(1), PRKCQ(1), PRKCZ(2), PRKD1(2), RAMP1(1), RGS10(1), RGS14(2), RGS16(3), RGS18(2), RGS19(1), RGS2(1), RGS3(1), RGS4(1), RGS5(2), RGS6(1), RGS7(4), RGS9(1), RLN1(1), RYR1(12), RYR2(21), RYR3(14), SFN(1), SLC8A1(2), SP1(3), TNXB(11), USP5(1), YWHAB(2), YWHAQ(1) 33396247 263 96 262 108 133 12 66 29 23 0 0.912 1.000 1.000 322 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(2), CADM1(1), CADM3(1), CD2(1), CD22(2), CD226(3), CD276(1), CD34(2), CD4(1), CD40(1), CD58(1), CD6(2), CD86(1), CD8A(2), CDH1(6), CDH15(3), CDH2(1), CDH3(1), CDH4(7), CDH5(4), CLDN1(1), CLDN10(1), CLDN17(2), CLDN19(1), CLDN2(1), CLDN23(1), CLDN4(1), CLDN5(1), CLDN6(1), CLDN8(1), CNTN1(4), CNTNAP2(8), F11R(1), GLG1(1), HLA-A(5), HLA-C(2), HLA-DMB(1), HLA-DQA1(1), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(1), HLA-DRB1(1), HLA-E(1), HLA-F(1), ICAM1(3), ICAM3(2), ICOS(2), ICOSLG(1), ITGA4(6), ITGA6(2), ITGA8(5), ITGA9(3), ITGAL(2), ITGAM(3), ITGAV(3), ITGB1(1), ITGB2(3), ITGB8(1), JAM2(1), JAM3(1), L1CAM(2), MADCAM1(1), MAG(1), MPZ(4), NCAM1(3), NCAM2(3), NEGR1(1), NEO1(3), NFASC(2), NLGN1(2), NRCAM(1), NRXN1(8), NRXN2(3), NRXN3(3), OCLN(3), PDCD1(1), PDCD1LG2(1), PTPRC(5), PTPRF(4), PTPRM(2), PVR(2), PVRL1(4), PVRL2(2), PVRL3(2), SDC1(2), SDC3(1), SELE(1), SELP(1), SPN(1), VCAM1(1), VCAN(9) 28500766 202 93 201 86 89 4 52 25 32 0 0.989 1.000 1.000 323 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 148 AKT3(1), BCL2L1(2), CBL(4), CBLB(6), CCND1(1), CISH(1), CLCF1(2), CNTF(1), CNTFR(1), CREBBP(18), CSF2RA(1), CSF2RB(1), CSF3R(2), EPOR(1), GHR(2), IFNA16(1), IFNA4(3), IFNAR1(1), IFNAR2(1), IFNG(1), IFNGR2(2), IL10RA(4), IL10RB(3), IL12B(2), IL12RB1(2), IL12RB2(1), IL13RA1(1), IL19(2), IL20RA(1), IL21(1), IL21R(5), IL22RA1(1), IL23A(1), IL23R(4), IL24(1), IL26(1), IL28A(1), IL28B(1), IL28RA(1), IL2RA(1), IL2RB(2), IL2RG(3), IL3RA(3), IL4R(1), IL5RA(2), IL6(2), IL6R(1), IL6ST(3), IL7(1), IL7R(2), IL9R(1), IRF9(2), JAK1(3), JAK2(2), JAK3(3), LEPR(4), LIFR(3), MPL(1), MYC(1), OSM(2), OSMR(3), PIAS3(1), PIAS4(2), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PRL(2), PRLR(1), SOCS5(1), SOCS7(1), SOS1(5), SOS2(4), SPRED1(2), SPRED2(2), SPRY1(1), SPRY4(2), STAM(1), STAM2(4), STAT1(4), STAT2(2), STAT4(1), STAT5B(2), STAT6(3), TPO(9), TYK2(2) 26600160 198 93 197 74 94 6 42 23 33 0 0.917 1.000 1.000 324 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 140 APC(7), APC2(3), AXIN1(3), AXIN2(4), CAMK2B(2), CAMK2D(1), CAMK2G(3), CCND1(1), CER1(2), CHD8(5), CREBBP(18), CSNK1A1(3), CSNK1A1L(1), CSNK1E(1), CSNK2A1(4), CSNK2B(2), CTBP1(1), CTBP2(1), CTNNB1(4), CTNNBIP1(1), CUL1(8), DAAM1(7), DAAM2(3), DKK1(1), DKK2(3), DKK4(1), DVL2(2), DVL3(1), FBXW11(1), FOSL1(1), FZD10(1), FZD3(3), FZD4(1), FZD6(4), FZD7(2), FZD8(1), FZD9(2), LEF1(2), LRP5(2), LRP6(1), MAP3K7(3), MAPK10(1), MAPK8(4), MAPK9(5), MYC(1), NFAT5(7), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), NLK(2), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PORCN(1), PPARD(1), PPP2CA(1), PPP2R1A(1), PPP2R1B(3), PPP2R2B(1), PPP2R2C(1), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(2), PRICKLE1(2), PRICKLE2(2), PRKACB(1), PRKCA(1), PRKCG(2), PRKX(1), PSEN1(5), RAC1(1), ROCK1(4), ROCK2(6), RUVBL1(3), SFRP2(1), SFRP4(2), SKP1(1), SMAD2(2), SMAD3(5), SMAD4(2), TBL1X(1), TBL1XR1(2), TBL1Y(2), VANGL1(2), VANGL2(3), WIF1(2), WNT2(2), WNT3A(1), WNT5A(1), WNT6(1), WNT7A(2), WNT7B(1), WNT8A(1) 29944436 247 92 244 77 110 16 59 24 38 0 0.586 1.000 1.000 325 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 53 ASH1L(13), ASH2L(1), CARM1(2), CTCFL(2), DOT1L(9), EED(3), EHMT1(2), EHMT2(4), EZH1(2), EZH2(3), FBXO11(1), HCFC1(4), HSF4(2), MEN1(1), MLL(21), MLL3(30), MLL4(13), MLL5(6), NSD1(7), OGT(2), PAXIP1(3), PPP1CA(4), PPP1CB(3), PRDM2(7), PRDM7(2), PRDM9(5), PRMT5(3), PRMT6(1), PRMT7(5), PRMT8(4), RBBP5(2), SETD1A(3), SETD2(9), SETD8(2), SETDB1(4), SETDB2(1), SMYD3(1), STK38(2), SUV420H1(9), SUZ12(4), WHSC1(7), WHSC1L1(2) 20640544 211 91 209 57 117 8 27 24 35 0 0.693 1.000 1.000 326 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 73 ACTB(5), ACTG1(4), ACTN1(2), ACTN2(3), ACTN3(2), ACTN4(4), ACVR1B(1), ACVR1C(1), CDH1(6), CREBBP(18), CSNK2A1(4), CSNK2B(2), CTNNA1(1), CTNNA2(2), CTNNA3(3), CTNNB1(4), EGFR(3), ERBB2(11), FARP2(2), FER(4), FGFR1(3), FYN(1), IGF1R(5), INSR(4), IQGAP1(3), LEF1(2), LMO7(4), MAP3K7(3), MAPK3(3), MET(5), MLLT4(3), NLK(2), PARD3(6), PTPRB(5), PTPRF(4), PTPRJ(2), PTPRM(2), PVRL1(4), PVRL2(2), PVRL3(2), PVRL4(2), RAC1(1), SMAD2(2), SMAD3(5), SMAD4(2), SNAI1(1), SORBS1(4), SRC(4), SSX2IP(1), TGFBR2(3), TJP1(3), VCL(1), WAS(1), WASF2(3), WASF3(1), WASL(1), YES1(1) 22134239 183 88 180 58 94 5 42 16 26 0 0.688 1.000 1.000 327 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 91 ADCY1(3), ADCY2(10), ADCY3(2), ADCY4(2), ADCY5(1), ADCY6(4), ADCY7(1), ADCY8(5), ADCY9(3), ADRB1(1), EGF(4), EGFR(3), GJA1(1), GJD2(2), GNAI1(1), GNAI3(2), GNAS(4), GRM1(7), GRM5(5), GUCY1A2(4), GUCY1A3(6), GUCY1B3(3), GUCY2C(3), GUCY2D(3), GUCY2F(2), HTR2B(2), HTR2C(1), ITPR1(7), ITPR2(9), ITPR3(4), MAP2K1(1), MAP3K2(2), MAPK3(3), MAPK7(2), NRAS(2), PDGFB(1), PDGFRA(7), PDGFRB(4), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PRKACB(1), PRKCA(1), PRKCG(2), PRKG1(1), PRKG2(4), PRKX(1), RAF1(1), SOS1(5), SOS2(4), SRC(4), TJP1(3), TUBA1A(2), TUBA1C(1), TUBA3C(3), TUBA3D(2), TUBA3E(1), TUBA8(1), TUBAL3(1), TUBB(1), TUBB2C(1), TUBB3(5), TUBB4(2), TUBB6(2), TUBB8(2) 25457263 191 87 190 75 91 8 58 20 14 0 0.826 1.000 1.000 328 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 108 ACTN1(2), ACTN2(3), ACTN3(2), ACTN4(4), ARHGAP5(8), CDH5(4), CLDN1(1), CLDN10(1), CLDN17(2), CLDN19(1), CLDN2(1), CLDN23(1), CLDN4(1), CLDN5(1), CLDN6(1), CLDN8(1), CTNNA1(1), CTNNA2(2), CTNNA3(3), CTNNB1(4), CXCR4(2), EZR(6), F11R(1), GNAI1(1), GNAI3(2), GRLF1(14), ICAM1(3), ITGA4(6), ITGAL(2), ITGAM(3), ITGB1(1), ITGB2(3), ITK(2), JAM2(1), JAM3(1), MAPK11(2), MAPK12(1), MAPK13(1), MAPK14(1), MLLT4(3), MMP2(2), MMP9(3), MYL2(2), MYLPF(1), NCF2(4), NCF4(2), NOX1(1), OCLN(3), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PLCG1(3), PLCG2(3), PRKCA(1), PRKCG(2), PTK2(3), PTK2B(3), RAC1(1), RAP1A(1), RAP1B(2), RAPGEF4(4), RHOH(1), ROCK1(4), ROCK2(6), SIPA1(3), TXK(4), VAV1(2), VAV2(1), VAV3(2), VCAM1(1), VCL(1) 23508872 180 87 180 56 89 5 38 19 29 0 0.484 1.000 1.000 329 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADCY1(3), ADCY2(10), ADCY3(2), ADCY4(2), ADCY5(1), ADCY6(4), ADCY7(1), ADCY8(5), ADCY9(3), ADK(3), ADSL(1), ADSS(2), AK3L1(1), AK7(2), ALLC(1), AMPD1(2), AMPD2(1), AMPD3(3), ATIC(1), DCK(1), ENPP1(2), ENTPD2(1), ENTPD3(3), ENTPD5(1), ENTPD6(1), ENTPD8(1), GART(1), GDA(3), GMPS(2), GUCY1A2(4), GUCY1A3(6), GUCY1B3(3), GUCY2C(3), GUCY2D(3), GUCY2F(2), IMPDH1(1), IMPDH2(2), NME4(1), NME7(1), NT5C1A(3), NT5C1B(3), NT5C2(2), NT5C3(2), NT5E(3), PDE10A(2), PDE11A(8), PDE1A(2), PDE1C(4), PDE2A(1), PDE3B(1), PDE4A(1), PDE4B(1), PDE4C(2), PDE4D(2), PDE5A(5), PDE6G(1), PDE6H(1), PDE7A(2), PDE7B(1), PDE8A(1), PDE9A(4), PFAS(1), PKLR(1), PKM2(2), PNPT1(3), POLA1(2), POLA2(3), POLD1(3), POLD2(3), POLD3(3), POLE(6), POLE2(1), POLR1A(5), POLR1B(1), POLR1C(1), POLR1D(2), POLR2B(1), POLR2C(2), POLR2D(1), POLR2E(1), POLR2F(1), POLR3A(5), POLR3B(3), POLR3H(1), PPAT(2), PRIM2(2), PRUNE(4), RRM1(1), RRM2(2), XDH(6) 31522643 211 86 211 84 107 7 53 21 23 0 0.958 1.000 1.000 330 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA1(1), ADRA1A(4), ADRA1B(1), ADRA1D(2), ADRA2C(1), ADRB1(1), ADRB2(2), AGTR2(1), AVPR1A(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BRS3(1), CCBP2(1), CCKBR(3), CCR1(1), CCR10(1), CCR3(3), CCR4(2), CCR5(2), CCR7(3), CCR8(1), CCRL1(1), CCRL2(1), CHML(2), CHRM1(1), CHRM3(4), CHRM4(1), CNR1(1), CNR2(3), CX3CR1(3), CXCR3(1), CXCR4(2), DRD3(1), EDNRA(1), EDNRB(2), F2R(2), F2RL1(3), F2RL3(1), FPR1(1), FSHR(1), GALR1(1), GALR2(3), GALR3(1), GALT(1), GHSR(1), GPR17(3), GPR173(1), GPR174(1), GPR37(2), GPR37L1(3), GPR4(2), GPR50(5), GPR63(2), GPR77(1), GPR83(1), GPR87(2), HCRTR2(2), HRH1(4), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(1), HTR1F(1), HTR2B(2), HTR2C(1), HTR4(2), HTR6(1), HTR7(1), LHCGR(2), MC3R(1), MC4R(2), MLNR(1), MTNR1A(1), NMBR(3), NPY1R(1), NPY5R(4), NTSR1(1), OPN1SW(1), OPRD1(2), OR10A5(2), OR11A1(1), OR1C1(2), OR1F1(1), OR1Q1(1), OR7A5(3), OR7C1(3), OR8B8(2), OXTR(1), P2RY1(1), P2RY10(1), P2RY13(2), P2RY2(1), PTAFR(1), PTGDR(3), PTGER2(1), PTGER4(2), PTGFR(2), PTGIR(1), RRH(1), SSTR1(1), SSTR3(2), SSTR4(3), SUCNR1(1), TRHR(2) 23466006 176 84 176 102 78 9 58 20 11 0 0.976 1.000 1.000 331 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 128 ACACA(13), ACACB(5), AKT3(1), ARAF(1), BRAF(1), CALM1(1), CALM2(1), CALML3(1), CALML6(1), CBL(4), CBLB(6), EIF4EBP1(1), EXOC7(2), FASN(2), FBP1(1), FOXO1(1), GYS1(3), GYS2(3), IKBKB(4), INPP5D(2), INSR(4), IRS1(3), IRS2(3), IRS4(8), LIPE(5), MAP2K1(1), MAPK10(1), MAPK3(3), MAPK8(4), MAPK9(5), MKNK1(1), NRAS(2), PCK1(3), PDE3A(5), PDE3B(1), PDPK1(1), PFKP(1), PHKA1(5), PHKA2(1), PHKB(1), PHKG2(2), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PKLR(1), PKM2(2), PPARGC1A(2), PPP1CA(4), PPP1CB(3), PPP1R3A(4), PPP1R3B(2), PPP1R3C(1), PPP1R3D(1), PRKAA2(4), PRKAB2(1), PRKACB(1), PRKAG1(2), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCI(1), PRKCZ(2), PRKX(1), PTPRF(4), PYGL(1), PYGM(4), RAF1(1), RHEB(1), RHOQ(1), RPS6(3), SHC2(1), SHC4(4), SLC2A4(1), SORBS1(4), SOS1(5), SOS2(4), SREBF1(4), TRIP10(2), TSC2(2) 30050802 208 84 206 85 112 6 46 23 21 0 0.971 1.000 1.000 332 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 103 ABL1(4), ANAPC1(5), ANAPC2(3), ANAPC4(3), ANAPC5(1), ANAPC7(2), ATM(19), ATR(3), BUB1(8), BUB1B(5), CCNA1(1), CCNB1(1), CCNB3(5), CCND1(1), CCNE2(1), CCNH(3), CDC14B(2), CDC16(1), CDC25A(1), CDC27(3), CDC6(5), CDC7(1), CDK2(1), CDK4(2), CDK6(1), CDK7(3), CDKN1B(5), CDKN2B(2), CDKN2D(1), CHEK1(1), CHEK2(5), CREBBP(18), CUL1(8), DBF4(6), E2F1(1), E2F2(1), E2F3(2), ESPL1(5), FZR1(2), GADD45A(1), HDAC1(1), HDAC2(1), MAD1L1(2), MAD2L1(1), MCM2(1), MCM3(1), MCM4(4), MCM6(2), ORC1L(1), ORC3L(3), PCNA(1), PKMYT1(1), PLK1(1), PRKDC(10), PTTG1(1), RBL1(1), RBL2(3), SFN(1), SKP1(1), SKP2(1), SMAD2(2), SMAD3(5), SMAD4(2), SMC1A(3), SMC1B(2), TGFB3(1), WEE1(2), YWHAB(2), YWHAE(2), YWHAQ(1), YWHAZ(3) 24466329 206 82 204 63 110 6 32 23 35 0 0.781 1.000 1.000 333 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT3(1), CAPN10(1), CAPN11(1), CAPN3(4), CAPN5(3), CAPN6(1), CAPN9(1), CAV2(1), CSK(4), DOCK1(4), FYN(1), ITGA10(1), ITGA11(4), ITGA2(3), ITGA2B(7), ITGA3(4), ITGA4(6), ITGA5(3), ITGA6(2), ITGA7(2), ITGA8(5), ITGA9(3), ITGAD(2), ITGAE(3), ITGAL(2), ITGAM(3), ITGAV(3), ITGB1(1), ITGB2(3), ITGB3(2), ITGB4(5), ITGB5(2), ITGB8(1), MAP2K1(1), MAP2K3(2), MAPK10(1), MAPK12(1), MAPK4(3), MAPK7(2), MYLK2(4), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PDPK1(1), PIK3R2(1), PTK2(3), RAC1(1), RAP1B(2), ROCK1(4), ROCK2(6), SDCCAG8(2), SORBS1(4), SOS1(5), SRC(4), TLN1(2), TNS1(8), VAV2(1), VAV3(2), VCL(1), ZYX(1) 25876391 158 82 158 62 75 3 41 22 17 0 0.929 1.000 1.000 334 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 73 ARAF(1), BRAF(1), CACNA1A(6), GNA13(5), GNAI1(1), GNAI3(2), GNAO1(2), GNAS(4), GNAZ(1), GRIA1(3), GRIA2(3), GRIA3(2), GRID2(2), GRM1(7), GRM5(5), GUCY1A2(4), GUCY1A3(6), GUCY1B3(3), GUCY2C(3), GUCY2D(3), GUCY2F(2), IGF1R(5), ITPR1(7), ITPR2(9), ITPR3(4), LYN(2), MAP2K1(1), MAPK3(3), NOS1(4), NOS3(6), NRAS(2), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PPP2CA(1), PPP2R1A(1), PPP2R1B(3), PPP2R2B(1), PPP2R2C(1), PRKCA(1), PRKCG(2), PRKG1(1), PRKG2(4), RAF1(1), RYR1(12) 21224257 158 81 156 64 74 6 38 26 14 0 0.905 1.000 1.000 335 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 76 ABL1(4), ACTN1(2), ACTR3(1), AKT3(1), ARHGEF6(2), ARHGEF7(3), BRAF(1), CSE1L(5), DOCK1(4), EPHB2(3), FYN(1), GRB7(1), GRLF1(14), ITGA1(1), ITGA10(1), ITGA11(4), ITGA2(3), ITGA3(4), ITGA4(6), ITGA5(3), ITGA6(2), ITGA7(2), ITGA8(5), ITGA9(3), MAP2K4(1), MAP2K7(2), MAPK10(1), MAPK8(4), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(3), MAPK9(5), MYLK(5), MYLK2(4), P4HB(3), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PAK7(2), PIK3CB(5), PKLR(1), PLCG1(3), PLCG2(3), PTEN(5), PTK2(3), RAF1(1), ROCK1(4), ROCK2(6), SOS1(5), SOS2(4), SRC(4), TERF2IP(2), TLN1(2), TLN2(5), WAS(1), ZYX(1) 23100646 172 81 172 52 92 4 33 19 24 0 0.504 1.000 1.000 336 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 89 ACTB(5), CABIN1(3), CALM1(1), CALM2(1), CAMK2B(2), CAMK4(1), CD3E(1), CEBPB(3), CNR1(1), CREBBP(18), CSNK2A1(4), CSNK2B(2), EGR2(1), EGR3(1), FCER1A(2), FOS(3), FOSL1(1), GATA3(1), GRLF1(14), GSK3A(1), ICOS(2), IFNG(1), IL1B(1), IL2RA(1), IL6(2), IL8(1), ITK(2), JUNB(4), KPNA5(1), MAP2K7(2), MAPK14(1), MAPK8(4), MAPK9(5), MEF2A(1), MEF2D(1), MYF5(1), NFAT5(7), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), NFKB2(1), NFKBIB(4), NFKBIE(5), NPPB(1), NUP214(3), OPRD1(2), P2RX7(1), PPIA(1), PPP3CB(4), PPP3CC(2), PPP3R1(1), PTPRC(5), RELA(2), SFN(1), SLA(1), SP1(3), SP3(2), TRAF2(2), TRPV6(2), VAV1(2), VAV2(1), VAV3(2), XPO5(6) 16488690 170 80 168 48 76 6 36 17 35 0 0.315 1.000 1.000 337 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 72 CALM1(1), CALM2(1), CALML3(1), CALML6(1), CDS1(2), DGKA(1), DGKB(2), DGKD(3), DGKE(1), DGKG(4), DGKH(2), DGKI(5), DGKQ(2), DGKZ(3), FN3K(2), IMPA1(1), IMPA2(1), INPP1(1), INPP4A(1), INPP4B(4), INPP5A(3), INPP5B(1), INPP5D(2), INPPL1(2), ITPK1(1), ITPKA(2), ITPKB(1), ITPR1(7), ITPR2(9), ITPR3(4), PI4KB(3), PIK3C2A(7), PIK3C2B(6), PIK3C2G(3), PIK3C3(5), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIP4K2A(2), PIP4K2B(1), PIP4K2C(3), PIP5K1A(5), PIP5K1C(2), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PLCD1(1), PLCD3(1), PLCD4(2), PLCE1(2), PLCG1(3), PLCG2(3), PLCZ1(2), PRKCA(1), PRKCG(2), PTEN(5), PTPMT1(1), SYNJ1(3), SYNJ2(2) 23621033 163 79 162 70 87 5 34 20 17 0 0.979 1.000 1.000 338 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 124 ARAF(1), BRAF(1), CASP3(1), CD244(2), CD247(1), FCGR3B(3), FYN(1), HCST(1), HLA-A(5), HLA-C(2), HLA-E(1), ICAM1(3), IFNA16(1), IFNA4(3), IFNAR1(1), IFNAR2(1), IFNG(1), IFNGR2(2), ITGAL(2), ITGB2(3), KIR2DL1(1), KIR2DL3(1), KIR3DL1(2), KLRD1(1), LAT(1), LCK(1), MAP2K1(1), MAPK3(3), MICA(2), MICB(1), NCR1(2), NCR2(2), NFAT5(7), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), NRAS(2), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PLCG1(3), PLCG2(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(2), PRF1(4), PRKCA(1), PRKCG(2), PTK2B(3), RAC1(1), RAF1(1), SH2D1B(1), SH3BP2(1), SHC2(1), SHC4(4), SOS1(5), SOS2(4), SYK(1), TNFRSF10A(4), TNFRSF10C(1), TNFRSF10D(1), TNFSF10(2), ULBP1(1), ULBP3(1), VAV1(2), VAV2(1), VAV3(2), ZAP70(1) 21375019 154 79 153 56 73 6 27 24 24 0 0.844 1.000 1.000 339 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 65 ADCY1(3), ADCY8(5), ARAF(1), BRAF(1), CACNA1C(5), CALM1(1), CALM2(1), CALML3(1), CALML6(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), CAMK4(1), CREBBP(18), GRIA1(3), GRIA2(3), GRIN1(6), GRIN2A(9), GRIN2B(3), GRIN2C(5), GRIN2D(2), GRM1(7), GRM5(5), ITPR1(7), ITPR2(9), ITPR3(4), MAP2K1(1), MAPK3(3), NRAS(2), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PPP1CA(4), PPP1CB(3), PPP1R12A(4), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(2), PRKACB(1), PRKCA(1), PRKCG(2), PRKX(1), RAF1(1), RAP1A(1), RAP1B(2), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), RPS6KA6(2) 18181108 167 79 165 51 71 11 43 25 17 0 0.300 1.000 1.000 340 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 81 ABL1(4), ABL2(1), AKT3(1), ARAF(1), BRAF(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), CBL(4), CBLB(6), CDKN1B(5), EGF(4), EGFR(3), EIF4EBP1(1), ERBB2(11), ERBB4(3), GAB1(2), MAP2K1(1), MAP2K4(1), MAP2K7(2), MAPK10(1), MAPK3(3), MAPK8(4), MAPK9(5), MYC(1), NCK1(1), NRAS(2), NRG1(5), NRG3(3), NRG4(1), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PAK7(2), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PLCG1(3), PLCG2(3), PRKCA(1), PRKCG(2), PTK2(3), RAF1(1), SHC2(1), SHC4(4), SOS1(5), SOS2(4), SRC(4), STAT5B(2) 18799402 139 78 138 51 71 5 31 19 13 0 0.868 1.000 1.000 341 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 86 ACVR1B(1), ACVR1C(1), ACVR2A(2), ACVRL1(3), AMHR2(1), BMP4(1), BMP5(1), BMP6(1), BMP8B(1), BMPR1A(1), BMPR1B(2), BMPR2(5), CDKN2B(2), CHRD(5), COMP(5), CREBBP(18), CUL1(8), E2F4(1), E2F5(1), FST(2), GDF5(1), GDF6(3), ID1(1), IFNG(1), INHBB(1), INHBE(2), LTBP1(5), MAPK3(3), MYC(1), NODAL(1), NOG(1), PPP2CA(1), PPP2R1A(1), PPP2R1B(3), PPP2R2B(1), PPP2R2C(1), RBL1(1), RBL2(3), ROCK1(4), ROCK2(6), SKP1(1), SMAD1(1), SMAD2(2), SMAD3(5), SMAD4(2), SMAD6(1), SMAD7(2), SMAD9(2), SMURF1(4), SMURF2(1), SP1(3), TGFB3(1), TGFBR2(3), THBS2(6), THBS3(2), THBS4(2), ZFYVE16(4), ZFYVE9(6) 18088555 151 78 149 44 70 7 36 16 22 0 0.528 1.000 1.000 342 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 94 ADCY1(3), ADCY2(10), ADCY3(2), ADCY4(2), ADCY5(1), ADCY6(4), ADCY7(1), ADCY8(5), ADCY9(3), CACNA1C(5), CACNA1D(5), CACNA1F(4), CACNA1S(5), CALM1(1), CALM2(1), CALML3(1), CALML6(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), EGFR(3), GNAS(4), GNRH1(1), ITPR1(7), ITPR2(9), ITPR3(4), MAP2K1(1), MAP2K3(2), MAP2K4(1), MAP2K7(2), MAP3K1(3), MAP3K2(2), MAP3K4(5), MAPK10(1), MAPK11(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK7(2), MAPK8(4), MAPK9(5), MMP14(1), MMP2(2), NRAS(2), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PLD1(3), PLD2(1), PRKACB(1), PRKCA(1), PRKCD(1), PRKX(1), PTK2B(3), RAF1(1), SOS1(5), SOS2(4), SRC(4) 24508536 175 78 174 86 76 8 53 20 18 0 0.997 1.000 1.000 343 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 97 AKT3(1), CASP8(4), CCL3(1), CD40(1), CD86(1), CHUK(6), CXCL11(1), FADD(1), FOS(3), IFNA16(1), IFNA4(3), IFNAR1(1), IFNAR2(1), IKBKB(4), IKBKE(2), IL12B(2), IL1B(1), IL6(2), IL8(1), IRAK4(3), IRF5(1), IRF7(1), LY96(1), MAP2K1(1), MAP2K3(2), MAP2K4(1), MAP2K7(2), MAP3K7(3), MAP3K8(2), MAPK10(1), MAPK11(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK8(4), MAPK9(5), MYD88(1), NFKB1(1), NFKB2(1), NFKBIA(2), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), RAC1(1), RELA(2), RIPK1(2), SPP1(1), STAT1(4), TBK1(3), TICAM1(2), TLR2(2), TLR3(2), TLR4(3), TLR5(5), TLR6(2), TLR7(6), TLR8(3), TLR9(2), TOLLIP(1), TRAF6(1) 16880020 133 77 133 45 68 5 23 15 22 0 0.651 1.000 1.000 344 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 90 ADCY1(3), ADCY2(10), ADCY3(2), ADCY4(2), ADCY5(1), ADCY6(4), ADCY7(1), ADCY8(5), ADCY9(3), AKAP1(3), AKAP10(3), AKAP11(8), AKAP12(2), AKAP3(2), AKAP4(1), AKAP5(1), AKAP6(7), AKAP8(1), AKAP9(15), ARHGEF1(6), CALM1(1), CALM2(1), CHMP1B(2), GNA13(5), GNA14(2), GNA15(1), GNAI3(2), GNAL(1), GNAO1(2), GNAZ(1), GNB1(5), GNB3(3), GNB5(2), GNG4(4), ITPR1(7), KCNJ3(1), NRAS(2), PALM2(1), PDE1A(2), PDE1C(4), PDE4A(1), PDE4B(1), PDE4C(2), PDE4D(2), PDE7A(2), PDE7B(1), PDE8A(1), PLCB3(6), PPP3CA(4), PPP3CC(2), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(1), PRKCD(1), PRKCG(2), PRKCI(1), PRKCQ(1), PRKCZ(2), PRKD1(2), PRKD3(7), RRAS(1), SLC9A1(1), USP5(1) 22437395 178 75 175 59 90 9 35 26 18 0 0.716 1.000 1.000 345 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 79 AGL(7), AMY2A(2), AMY2B(1), ASCC3(5), ATP13A2(5), DDX18(2), DDX19A(1), DDX23(3), DDX4(3), DDX47(2), DDX50(1), DDX51(1), DDX52(1), DDX54(4), DDX55(2), ENPP1(2), ENTPD7(2), EP400(7), ERCC3(2), GAA(2), GANC(3), GBA(2), GBA3(2), GBE1(2), GPI(3), GUSB(1), GYS1(3), GYS2(3), HK1(3), HK2(3), HK3(3), IFIH1(3), MGAM(6), MOV10L1(1), PGM1(2), PYGL(1), PYGM(4), RAD54B(4), RAD54L(1), RUVBL2(1), SETX(5), SI(5), SKIV2L2(2), SMARCA2(9), SMARCA5(1), TREH(1), UGDH(2), UGP2(5), UGT1A1(3), UGT1A3(3), UGT1A5(1), UGT1A6(1), UGT1A9(2), UGT2A1(1), UGT2A3(3), UGT2B10(2), UGT2B28(2), UGT2B4(2), UGT2B7(1) 23526830 157 75 155 57 76 11 36 20 14 0 0.921 1.000 1.000 346 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(6), BDKRB1(1), C1R(1), C1S(2), C2(1), C3(5), C4BPA(4), C5(3), C8A(2), C8B(2), C9(5), CD46(2), CD55(1), CFB(2), CFH(6), CFI(1), CPB2(3), CR1(3), CR2(6), F10(1), F11(3), F12(1), F13A1(2), F13B(1), F2R(2), F5(9), F8(5), F9(1), FGA(7), FGB(1), FGG(3), KLKB1(1), KNG1(1), MASP1(3), MASP2(3), PLAT(1), PLAU(1), PLAUR(6), PROS1(4), SERPINC1(1), SERPIND1(5), SERPINE1(2), SERPING1(1), THBD(2), VWF(7) 17450494 130 73 130 35 66 6 34 11 13 0 0.256 1.000 1.000 347 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 89 AKT3(1), BCL10(1), CARD11(5), CBL(4), CBLB(6), CD247(1), CD3E(1), CD4(1), CD8A(2), CDK4(2), CHUK(6), FOS(3), FYN(1), GRAP2(2), ICOS(2), IFNG(1), IKBKB(4), ITK(2), LAT(1), LCK(1), MALT1(5), MAP3K14(2), MAP3K8(2), NCK1(1), NFAT5(7), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), NRAS(2), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PAK7(2), PDCD1(1), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(2), PRKCQ(1), PTPRC(5), RASGRP1(1), SOS1(5), SOS2(4), TEC(4), VAV1(2), VAV2(1), VAV3(2), ZAP70(1) 19015282 158 73 158 47 81 7 25 22 23 0 0.529 1.000 1.000 348 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 97 ADCY1(3), ADCY2(10), ADCY3(2), ADCY4(2), ADCY5(1), ADCY6(4), ADCY7(1), ADCY8(5), ADCY9(3), CALM1(1), CALM2(1), CALML3(1), CALML6(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), CREB3L2(1), CREB3L3(5), CREB3L4(2), CREBBP(18), CTNNB1(4), DCT(3), DVL2(2), DVL3(1), EDNRB(2), FZD10(1), FZD3(3), FZD4(1), FZD6(4), FZD7(2), FZD8(1), FZD9(2), GNAI1(1), GNAI3(2), GNAO1(2), GNAS(4), KIT(3), KITLG(2), LEF1(2), MAP2K1(1), MAPK3(3), MITF(1), NRAS(2), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PRKACB(1), PRKCA(1), PRKCG(2), PRKX(1), RAF1(1), TYR(3), WNT2(2), WNT3A(1), WNT5A(1), WNT6(1), WNT7A(2), WNT7B(1), WNT8A(1) 20017599 147 73 145 72 64 5 48 19 11 0 0.987 1.000 1.000 349 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CDC40(1), CLK4(1), COL2A1(4), CPSF1(2), CPSF3(2), CPSF4(1), CSTF2(1), CSTF2T(3), CSTF3(1), DDX1(1), DDX20(2), DHX16(3), DHX38(1), DHX8(2), DHX9(6), DICER1(5), FUS(4), LOC440563(3), LSM2(1), METTL3(2), NCBP1(1), NONO(1), NXF1(5), PABPN1(2), PAPOLA(7), PPM1G(3), PRPF18(1), PRPF3(1), PRPF4(3), PRPF4B(1), PRPF8(3), PTBP1(1), PTBP2(4), RBM17(2), RBM5(3), RNGTT(1), RNPS1(1), SF3A1(2), SF3A3(2), SF3B1(8), SF3B2(2), SF3B4(1), SF3B5(1), SF4(2), SFRS14(2), SFRS16(1), SFRS2(3), SFRS6(3), SFRS8(3), SFRS9(3), SNRPB(2), SNRPB2(2), SNRPG(2), SPOP(2), SRPK2(2), SUPT5H(5), U2AF1(1), U2AF2(2), XRN2(3) 20460628 140 72 139 45 73 7 24 12 24 0 0.917 1.000 1.000 350 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 81 ACVR1B(1), ACVRL1(3), BMPR1A(1), BMPR2(5), BUB1(8), CDKL1(3), CDKL2(2), CDS1(2), CLK1(3), CLK4(1), COL4A3BP(1), CSNK2A1(4), CSNK2B(2), DGKA(1), DGKB(2), DGKD(3), DGKE(1), DGKG(4), DGKH(2), DGKQ(2), DGKZ(3), IMPA1(1), INPP1(1), INPP4A(1), INPP4B(4), INPP5A(3), INPPL1(2), ITPKA(2), ITPKB(1), MAP3K10(1), MOS(2), NEK3(1), PAK4(1), PIK3C2A(7), PIK3C2B(6), PIK3C2G(3), PIK3CB(5), PIK3CG(3), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PLCD1(1), PLCG1(3), PLCG2(3), PLK3(3), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(1), PRKCD(1), PRKCG(2), PRKCQ(1), PRKCZ(2), PRKD1(2), PRKG1(1), RAF1(1), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), RPS6KA4(1), VRK1(1) 21377552 147 71 145 56 69 7 32 23 16 0 0.924 1.000 1.000 351 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 76 ABL1(4), ATM(19), BUB1(8), BUB1B(5), CCNA1(1), CCNB1(1), CCNB3(5), CCNE2(1), CCNH(3), CDAN1(4), CDC14B(2), CDC25A(1), CDC6(5), CDC7(1), CDH1(6), CDK2(1), CDK4(2), CHEK1(1), CHEK2(5), DTX4(1), E2F1(1), E2F2(1), E2F3(2), E2F4(1), E2F5(1), E2F6(1), ESPL1(5), GADD45A(1), HDAC1(1), HDAC2(1), HDAC4(2), HDAC5(2), HDAC6(2), HDAC8(1), MAD1L1(2), MAD2L1(1), MCM2(1), MCM3(1), MCM4(4), MCM6(2), MPEG1(2), MPL(1), ORC1L(1), ORC3L(3), PCNA(1), PLK1(1), PRKDC(10), PTPRA(1), PTTG1(1), RBL1(1), SKP2(1), SMAD4(2), TBC1D8(3), WEE1(2) 19480048 139 70 139 59 77 4 17 20 21 0 0.990 1.000 1.000 352 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(6), ABCA10(7), ABCA12(6), ABCA13(13), ABCA2(1), ABCA3(1), ABCA4(3), ABCA5(3), ABCA6(4), ABCA7(2), ABCA8(8), ABCA9(7), ABCB1(6), ABCB4(3), ABCB5(3), ABCB6(1), ABCB7(1), ABCB8(2), ABCB9(1), ABCC1(8), ABCC10(2), ABCC11(5), ABCC12(4), ABCC2(2), ABCC3(8), ABCC4(3), ABCC5(3), ABCC6(1), ABCC8(4), ABCC9(7), ABCD1(1), ABCD2(3), ABCD3(7), ABCG1(2), ABCG4(4), ABCG5(2), CFTR(2), TAP1(1), TAP2(1) 22683898 148 70 148 56 83 3 26 15 21 0 0.606 1.000 1.000 353 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADCY1(3), ADCY2(10), ADCY3(2), ADCY4(2), ADCY5(1), ADCY6(4), ADCY7(1), ADCY8(5), ADK(3), ADSL(1), ADSS(2), ALLC(1), AMPD1(2), AMPD2(1), AMPD3(3), ATIC(1), ATP5A1(1), ATP5B(2), ATP5C1(1), ATP5G1(1), ATP5J(1), DCK(1), ENPP1(2), ENTPD2(1), GART(1), GDA(3), GMPS(2), GUCY1A2(4), GUCY1A3(6), GUCY1B3(3), GUCY2C(3), GUCY2D(3), GUCY2F(2), IMPDH1(1), IMPDH2(2), NT5E(3), PDE1A(2), PDE4A(1), PDE4B(1), PDE4C(2), PDE4D(2), PDE5A(5), PDE6B(1), PDE6C(2), PDE6G(1), PDE7B(1), PDE8A(1), PDE9A(4), PFAS(1), PKLR(1), PKM2(2), POLD1(3), POLD2(3), POLE(6), POLQ(8), POLR1B(1), POLR2B(1), POLR2C(2), POLR2D(1), POLR2E(1), POLR2F(1), POLRMT(2), PPAT(2), PRUNE(4), RRM1(1), RRM2(2) 24748758 150 69 150 66 84 6 34 13 13 0 0.971 1.000 1.000 354 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 67 AKT3(1), CASP9(3), KDR(9), MAP2K1(1), MAPK11(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPKAPK2(1), NFAT5(7), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), NOS3(6), NRAS(2), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), PLCG1(3), PLCG2(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(2), PRKCA(1), PRKCG(2), PTGS2(2), PTK2(3), RAC1(1), RAF1(1), SH2D2A(3), SHC2(1), SPHK2(4), SRC(4) 13448571 114 68 114 31 53 5 21 18 17 0 0.250 1.000 1.000 355 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(3), CD19(2), CD1A(3), CD1B(1), CD1C(2), CD1D(2), CD1E(3), CD2(1), CD22(2), CD33(2), CD34(2), CD36(1), CD38(1), CD3E(1), CD4(1), CD5(1), CD55(1), CD7(2), CD8A(2), CR1(3), CR2(6), CSF1(2), CSF1R(6), CSF2RA(1), CSF3R(2), DNTT(4), EPOR(1), FCGR1A(1), FLT3(3), GP5(1), HLA-DRA(1), HLA-DRB1(1), IL1A(1), IL1B(1), IL2RA(1), IL3RA(3), IL4R(1), IL5RA(2), IL6(2), IL6R(1), IL7(1), IL7R(2), IL9R(1), ITGA1(1), ITGA2(3), ITGA2B(7), ITGA3(4), ITGA4(6), ITGA5(3), ITGA6(2), ITGAM(3), ITGB3(2), KIT(3), KITLG(2), MME(4), MS4A1(3), TFRC(2), THPO(1), TPO(9) 15758645 136 68 136 39 62 6 37 20 11 0 0.286 1.000 1.000 356 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 60 AKT3(1), BCL10(1), BLNK(1), BTK(3), CARD11(5), CD19(2), CD22(2), CD79A(1), CD79B(1), CHUK(6), CR2(6), FCGR2B(1), FOS(3), IKBKB(4), INPP5D(2), LILRB3(2), LYN(2), MALT1(5), NFAT5(7), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), NRAS(2), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PLCG2(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(2), RAC1(1), RASGRP3(2), SYK(1), VAV1(2), VAV2(1), VAV3(2) 13885455 122 68 122 40 52 7 23 18 22 0 0.699 1.000 1.000 357 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 83 BRAF(1), CHUK(6), DAXX(1), FOS(3), IKBKB(4), MAP2K1(1), MAP2K3(2), MAP2K4(1), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K12(1), MAP3K13(6), MAP3K14(2), MAP3K2(2), MAP3K4(5), MAP3K5(4), MAP3K6(3), MAP3K7(3), MAP3K8(2), MAP3K9(1), MAP4K1(3), MAP4K2(4), MAP4K3(4), MAP4K4(2), MAP4K5(1), MAPK10(1), MAPK11(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK4(3), MAPK7(2), MAPK8(4), MAPK9(5), MAPKAPK2(1), MEF2A(1), MEF2C(2), MEF2D(1), MKNK1(1), MYC(1), NFKB1(1), NFKBIA(2), PAK2(1), RAC1(1), RAF1(1), RELA(2), RIPK1(2), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), RPS6KA4(1), RPS6KA5(3), SP1(3), STAT1(4), TGFB3(1), TRADD(1), TRAF2(2) 18316486 129 68 129 45 59 5 29 15 21 0 0.808 1.000 1.000 358 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(1), ALG1(2), ALG13(1), ALG2(2), ALG6(1), ALG9(1), B3GNT1(1), B3GNT2(2), B3GNT7(1), B4GALT1(1), B4GALT7(1), C1GALT1(1), C1GALT1C1(1), CHPF(2), CHST11(1), CHST12(1), CHST14(1), CHST2(1), CHST4(2), CHST6(1), CHST7(1), CHSY1(2), EXT1(4), EXT2(3), EXTL1(1), EXTL2(2), EXTL3(2), FUT11(2), FUT8(5), GALNT1(1), GALNT11(1), GALNT12(1), GALNT13(1), GALNT2(2), GALNT3(1), GALNT4(1), GALNT5(3), GALNT6(1), GALNT7(1), GALNT8(2), GALNT9(1), GALNTL2(3), GALNTL5(1), GANAB(8), GCNT1(1), GCNT4(1), HS2ST1(1), HS3ST5(1), HS6ST1(1), MAN1A1(3), MAN1A2(2), MAN1B1(5), MAN1C1(4), MAN2A1(5), MGAT1(4), MGAT2(1), MGAT3(1), MGAT4A(2), MGAT5B(1), NDST2(1), NDST3(2), NDST4(2), OGT(2), ST3GAL1(1), ST6GAL1(1), ST6GALNAC1(1), UST(1), WBSCR17(3), XYLT1(3), XYLT2(2) 21218133 127 67 126 56 75 3 17 20 12 0 0.945 1.000 1.000 359 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 78 AKT3(1), APAF1(1), ATM(19), BAX(1), BCL2L1(2), BIRC3(1), CASP3(1), CASP6(1), CASP8(4), CASP9(3), CFLAR(1), CHUK(6), CSF2RB(1), DFFA(4), FADD(1), IKBKB(4), IL1A(1), IL1B(1), IL1RAP(1), IL3RA(3), IRAK2(1), IRAK3(3), IRAK4(3), MAP3K14(2), MYD88(1), NFKB1(1), NFKB2(1), NFKBIA(2), NTRK1(4), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(2), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), RELA(2), RIPK1(2), TNFRSF10A(4), TNFRSF10C(1), TNFRSF10D(1), TNFSF10(2), TRADD(1), TRAF2(2) 15559267 124 66 124 41 60 5 24 14 21 0 0.711 1.000 1.000 360 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 42 ADAM17(1), APH1A(2), CREBBP(18), CTBP1(1), CTBP2(1), DLL1(4), DLL3(2), DLL4(1), DTX1(5), DTX2(2), DTX3(1), DTX4(1), DVL2(2), DVL3(1), HDAC1(1), HDAC2(1), HES1(4), JAG1(4), LFNG(1), MAML1(1), MAML2(5), MAML3(3), NCOR2(10), NCSTN(6), NOTCH1(5), NOTCH2(5), NOTCH3(3), NOTCH4(4), NUMB(1), PSEN1(5), RBPJ(2), RBPJL(2), SNW1(1) 12456920 106 64 104 36 47 3 29 10 17 0 0.701 1.000 1.000 361 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 58 ALG2(2), BAX(1), BFAR(2), BTK(3), CAD(7), CASP3(1), CASP8(4), CASP8AP2(7), CD7(2), CSNK1A1(3), DAXX(1), DFFA(4), EGFR(3), EPHB2(3), FADD(1), FAF1(1), IL1A(1), IL8(1), MAP2K4(1), MAP2K7(2), MAP3K1(3), MAP3K5(4), MAPK10(1), MAPK8(4), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(3), MAPK9(5), MET(5), NFAT5(7), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), NFKBIL2(2), PFN1(2), PTPN13(7), RALBP1(1), RIPK1(2), ROCK1(4), SMPD1(3), TPX2(1), TRAF2(2) 13856379 123 64 123 36 68 2 25 12 16 0 0.504 1.000 1.000 362 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 45 AKT3(1), BLNK(1), BTK(3), CD19(2), CD22(2), CR2(6), CSK(4), DAG1(1), GSK3A(1), INPP5D(2), ITPR1(7), ITPR2(9), ITPR3(4), LYN(2), MAP4K1(3), MAPK3(3), NFATC1(4), NFATC2(6), PIK3CD(3), PIK3R1(2), PLCG2(3), PPP1R13B(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PTPRC(5), RAF1(1), SOS1(5), SOS2(4), SYK(1), VAV1(2) 13893710 100 63 100 36 52 8 15 13 12 0 0.730 1.000 1.000 363 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 51 ACTG1(4), APAF1(1), BAG4(1), BIRC3(1), CASP3(1), CASP6(1), CASP8(4), CASP9(3), CFLAR(1), CHUK(6), DAXX(1), DFFA(4), FADD(1), LMNA(1), LMNB1(2), LMNB2(1), MAP2K7(2), MAP3K1(3), MAP3K14(2), MAP3K5(4), MAPK8(4), NFKB1(1), NFKBIA(2), NUMA1(4), PAK2(1), PRKCD(1), PRKDC(10), PSEN1(5), PTK2(3), RASA1(4), RELA(2), RIPK1(2), SPTAN1(34), TNFRSF1B(3), TRADD(1), TRAF2(2) 13005034 123 62 123 51 68 4 25 6 20 0 0.990 1.000 1.000 364 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 69 ACACB(5), ACSL1(1), ACSL5(1), ACSL6(2), ADIPOR1(2), AGRP(1), AKT3(1), CAMKK2(3), CD36(1), CHUK(6), CPT1A(2), CPT1B(2), CPT1C(2), IKBKB(4), IRS1(3), IRS2(3), IRS4(8), JAK1(3), JAK2(2), JAK3(3), LEPR(4), MAPK10(1), MAPK8(4), MAPK9(5), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), PCK1(3), PPARGC1A(2), PRKAA2(4), PRKAB2(1), PRKAG1(2), PRKCQ(1), RELA(2), RXRG(5), SLC2A1(3), SLC2A4(1), TNFRSF1B(3), TRADD(1), TRAF2(2), TYK2(2) 15891464 114 62 113 40 53 4 30 11 16 0 0.694 1.000 1.000 365 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(3), ADAM17(1), ATP6V0A1(6), ATP6V0A2(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V0E1(1), ATP6V1A(3), ATP6V1B1(6), ATP6V1C1(3), ATP6V1E1(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1H(4), CASP3(1), CHUK(6), CSK(4), EGFR(3), F11R(1), GIT1(2), IGSF5(2), IKBKB(4), IL8(1), JAM2(1), JAM3(1), LYN(2), MAP2K4(1), MAP3K14(2), MAPK10(1), MAPK11(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK8(4), MAPK9(5), MET(5), NFKB1(1), NFKB2(1), NFKBIA(2), NOD1(1), PLCG1(3), PLCG2(3), PTPRZ1(7), RAC1(1), RELA(2), SRC(4), TCIRG1(1), TJP1(3) 13600610 115 62 115 29 58 5 30 8 14 0 0.139 1.000 1.000 366 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 60 AKT3(1), BCL2L1(2), CDK2(1), CDKN1B(5), CREB5(5), ERBB4(3), GAB1(2), GADD45A(1), GSK3A(1), IFI27(1), INPPL1(2), IRS1(3), IRS2(3), IRS4(8), MET(5), MYC(1), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PAK7(2), PARD3(6), PARD6A(3), PIK3CD(3), PPP1R13B(3), PREX1(3), PTEN(5), PTK2(3), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), SFN(1), SLC2A4(1), SOS1(5), SOS2(4), TSC2(2), YWHAB(2), YWHAE(2), YWHAQ(1), YWHAZ(3) 13970786 106 61 106 33 51 3 24 7 21 0 0.685 1.000 1.000 367 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ALG6(1), CCKBR(3), CCR3(3), CCR5(2), CELSR1(8), CELSR2(5), CELSR3(18), CHRM3(4), CIDEB(1), CXCR3(1), EDNRA(1), EMR2(1), F2R(2), FSHR(1), GHRHR(1), GPR116(2), GPR133(5), GPR135(1), GPR17(3), GPR55(2), GPR56(4), GPR61(4), GPR77(1), GPR84(2), GPR88(3), GRM1(7), HRH4(1), LGR6(3), LPHN2(8), LPHN3(5), LTB4R2(2), NTSR1(1), OR2M4(1), OR8G2(1), P2RY13(2), PTGFR(2), SMO(2), TAAR5(1), TSHR(2) 12862475 117 60 117 58 43 7 37 14 16 0 0.910 1.000 1.000 368 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 41 ASAH1(2), ATF1(1), BRAF(1), CREB5(5), CREBBP(18), DAG1(1), EGR1(1), EGR2(1), EGR3(1), FRS2(3), MAP1B(6), MAP2K4(1), MAP2K7(2), MAPK10(1), MAPK3(3), MAPK8(4), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(3), MAPK9(5), NTRK1(4), PIK3C2G(3), PIK3CD(3), PIK3R1(2), RPS6KA3(2), SRC(4), TERF2IP(2) 9480126 83 60 82 27 37 4 20 9 13 0 0.622 1.000 1.000 369 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 46 FN3K(2), IMPA1(1), IMPA2(1), INPP1(1), INPP4A(1), INPP4B(4), INPP5A(3), INPP5B(1), INPPL1(2), ISYNA1(1), ITPK1(1), ITPKA(2), ITPKB(1), MINPP1(1), PI4KB(3), PIK3C3(5), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIP4K2A(2), PIP4K2B(1), PIP4K2C(3), PIP5K1A(5), PIP5K1C(2), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PLCD1(1), PLCD3(1), PLCD4(2), PLCE1(2), PLCG1(3), PLCG2(3), PLCZ1(2), PTEN(5), PTPMT1(1), SYNJ1(3), SYNJ2(2) 13936201 92 59 91 42 52 0 23 10 7 0 0.969 1.000 1.000 370 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 59 ATM(19), CCNA1(1), CCNB1(1), CCND1(1), CCNE2(1), CCNH(3), CDC25A(1), CDK2(1), CDK4(2), CDK7(3), CDKN1B(5), CDKN2B(2), CDKN2D(1), CREB3L3(5), CREB3L4(2), E2F1(1), E2F2(1), E2F3(2), E2F4(1), E2F5(1), E2F6(1), GADD45A(1), MCM2(1), MCM3(1), MCM4(4), MCM6(2), MNAT1(1), MYC(1), MYT1(3), NACA(1), ORC1L(1), ORC3L(3), PCNA(1), POLA2(3), POLE(6), POLE2(1), RBL1(1), RPA3(3), TNXB(11), WEE1(2) 14128025 102 58 102 43 58 3 14 8 19 0 0.979 1.000 1.000 371 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(3), ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), ALDH3A1(2), ALDH3B1(2), AOC3(1), AOX1(2), CARM1(2), COMT(2), DBH(3), DCT(3), DDC(3), ESCO1(1), ESCO2(1), GSTZ1(1), HPD(2), LCMT2(1), MAOA(1), METTL2B(1), MYST3(5), MYST4(3), PNPLA3(2), PRMT5(3), PRMT6(1), PRMT7(5), PRMT8(4), TPO(9), TYR(3), WBSCR22(3) 11472515 77 58 76 22 35 2 23 13 4 0 0.348 1.000 1.000 372 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 65 APAF1(1), BAX(1), BCL2L1(2), BIRC3(1), BIRC5(1), CASP1(2), CASP3(1), CASP4(2), CASP6(1), CASP8(4), CASP9(3), CHUK(6), DFFA(4), FADD(1), HELLS(1), IKBKB(4), IRF1(1), IRF2(1), IRF4(1), IRF5(1), IRF6(3), IRF7(1), MAP2K4(1), MAP3K1(3), MAPK10(1), MYC(1), NFKB1(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), PLEKHG5(2), PRF1(4), RELA(2), RIPK1(2), TNFRSF1B(3), TNFRSF21(3), TNFRSF25(3), TNFSF10(2), TP73(2), TRADD(1), TRAF2(2) 10945874 87 56 87 30 38 2 26 7 14 0 0.769 1.000 1.000 373 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 CAD(7), CTPS(1), DCK(1), DCTD(1), DPYD(5), DPYS(5), DUT(1), ENTPD3(3), ENTPD5(1), ENTPD6(1), ENTPD8(1), NME4(1), NME7(1), NT5C1A(3), NT5C1B(3), NT5C2(2), NT5C3(2), NT5E(3), PNPT1(3), POLA1(2), POLA2(3), POLD1(3), POLD2(3), POLD3(3), POLE(6), POLE2(1), POLR1A(5), POLR1B(1), POLR1C(1), POLR1D(2), POLR2B(1), POLR2C(2), POLR2D(1), POLR2E(1), POLR2F(1), POLR3A(5), POLR3B(3), POLR3H(1), PRIM2(2), RRM1(1), RRM2(2), TK1(1), TXNRD1(3), TXNRD2(1), TYMS(1), UMPS(1), UPB1(3), UPRT(1) 15663266 106 56 106 36 56 3 19 16 12 0 0.732 1.000 1.000 374 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 43 ACTR3(1), AKT3(1), ARHGAP1(1), ARHGEF11(3), BTK(3), CFL2(1), GDI1(2), INPPL1(2), ITPR1(7), ITPR2(9), ITPR3(4), LIMK1(2), MYLK(5), MYLK2(4), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PAK7(2), PIK3CD(3), PIK3CG(3), PIK3R1(2), PPP1R13B(3), PTEN(5), RACGAP1(1), ROCK1(4), ROCK2(6), RPS4X(2), WASL(1) 13146602 84 56 84 28 44 2 12 13 13 0 0.674 1.000 1.000 375 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(6), ATP4A(2), ATP5A1(1), ATP5B(2), ATP5C1(1), ATP5G1(1), ATP5J(1), ATP5O(1), ATP6V0A1(6), ATP6V0A2(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V0E1(1), ATP6V1A(3), ATP6V1B1(6), ATP6V1C1(3), ATP6V1E1(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1H(4), COX10(2), COX15(1), COX5A(1), COX6A1(3), COX6A2(1), COX6C(1), COX7A1(1), COX7B2(1), COX8A(1), CYC1(1), LHPP(2), NDUFA12(1), NDUFA13(2), NDUFA5(1), NDUFA6(1), NDUFA7(1), NDUFA8(1), NDUFB5(1), NDUFB6(1), NDUFB9(3), NDUFS1(2), NDUFS2(1), NDUFS6(1), NDUFV1(2), PPA1(1), SDHA(3), SDHC(2), TCIRG1(1), UQCRB(1), UQCRC2(2), UQCRH(1) 10801393 90 55 88 25 42 7 22 10 9 0 0.253 1.000 1.000 376 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 49 ACTA1(3), AGT(1), CALM1(1), CALM2(1), CAMK4(1), CREBBP(18), CSNK1A1(3), HAND2(1), MAP2K1(1), MAPK14(1), MAPK3(3), MAPK8(4), MEF2C(2), MYH2(5), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), PIK3R1(2), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), RAF1(1), SYT1(2) 9281325 80 54 79 27 34 5 17 9 15 0 0.715 1.000 1.000 377 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR2(1), ATP8A1(1), AVPR1A(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BRS3(1), CCKBR(3), CCR1(1), CCR10(1), CCR3(3), CCR4(2), CCR5(2), CCR7(3), CCR8(1), CX3CR1(3), CXCR3(1), CXCR4(2), EDNRA(1), EDNRB(2), FPR1(1), FSHR(1), GALR1(1), GALR2(3), GALR3(1), GALT(1), GHSR(1), GPR77(1), LHCGR(2), MC3R(1), MC4R(2), NMBR(3), NPY1R(1), NPY5R(4), NTSR1(1), OPRD1(2), OXTR(1), SSTR1(1), SSTR3(2), SSTR4(3), TACR1(2), TACR3(1), TRHR(2), TSHR(2) 10121851 72 54 72 48 32 0 24 10 6 0 0.994 1.000 1.000 378 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 ABP1(3), ACAT1(1), AFMID(2), ALDH3A1(2), ALDH9A1(2), AOC3(1), AOX1(2), CARM1(2), CAT(3), CYP1A1(1), CYP1A2(2), CYP1B1(2), DDC(3), EHHADH(1), GCDH(2), HAAO(1), HADH(1), HADHA(3), HSD17B10(1), HSD17B4(3), KMO(1), LCMT2(1), LNX1(2), MAOA(1), METTL2B(1), NFX1(3), OGDH(5), OGDHL(4), PRMT5(3), PRMT6(1), PRMT7(5), PRMT8(4), TDO2(1), WBSCR22(3) 11708801 73 53 72 21 40 6 10 11 6 0 0.377 1.000 1.000 379 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(4), AGPAT2(1), AGPAT3(2), CDS1(2), CHAT(2), CHKA(1), CHKB(3), CHPT1(2), DGKA(1), DGKB(2), DGKD(3), DGKE(1), DGKG(4), DGKH(2), DGKI(5), DGKQ(2), DGKZ(3), ESCO1(1), ESCO2(1), ETNK1(1), GPD1(1), GPD1L(1), GPD2(1), LCAT(1), MYST3(5), MYST4(3), PCYT1A(1), PHOSPHO1(1), PISD(2), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), PLD1(3), PLD2(1), PNPLA3(2), PPAP2A(5), PPAP2B(1), PPAP2C(1), PTDSS1(2) 12633261 82 53 82 36 42 4 17 9 10 0 0.959 1.000 1.000 380 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(15), B3GALT4(4), CDR1(2), DGKI(5), FAU(2), IL6ST(3), MRPL19(1), PIGK(3), RPL10(2), RPL11(2), RPL13(1), RPL15(1), RPL23(1), RPL24(2), RPL26(2), RPL28(1), RPL3(1), RPL31(3), RPL35A(1), RPL36(1), RPL37(1), RPL3L(1), RPL4(3), RPL5(1), RPL6(1), RPL7(1), RPLP0(1), RPS13(1), RPS18(4), RPS27A(1), RPS4X(2), RPS6(3), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), RPS6KA6(2), RPS7(1), RPS9(1), SLC36A2(1), TBC1D10C(1), UBA52(1), UBB(2) 10110488 88 53 88 35 46 4 19 10 9 0 0.863 1.000 1.000 381 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), AKR1C4(1), ALDH3A1(2), ALDH3B1(2), CYP1A1(1), CYP1A2(2), CYP1B1(2), CYP2B6(2), CYP2C18(1), CYP2C19(1), CYP2C9(2), CYP2E1(1), CYP2F1(2), CYP3A4(5), CYP3A43(1), CYP3A7(6), DHDH(3), GSTA1(1), GSTA2(1), GSTA4(1), GSTA5(2), GSTM2(1), GSTM3(1), GSTM5(2), GSTP1(2), GSTZ1(1), UGT1A1(3), UGT1A3(3), UGT1A5(1), UGT1A6(1), UGT1A9(2), UGT2A1(1), UGT2A3(3), UGT2B10(2), UGT2B28(2), UGT2B4(2), UGT2B7(1) 11033323 75 52 75 30 38 6 15 7 9 0 0.776 1.000 1.000 382 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(7), AMY2A(2), AMY2B(1), ENPP1(2), GAA(2), GANAB(8), GBA3(2), GBE1(2), GPI(3), GUSB(1), GYS1(3), GYS2(3), HK1(3), HK2(3), HK3(3), MGAM(6), PGM1(2), PYGL(1), PYGM(4), SI(5), UCHL1(1), UGDH(2), UGT1A1(3), UGT1A3(3), UGT1A5(1), UGT1A6(1), UGT1A9(2), UGT2B4(2) 10951877 78 52 77 32 36 4 21 7 10 0 0.924 1.000 1.000 383 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 40 CALM1(1), CALM2(1), CD3E(1), FOS(3), FYN(1), LAT(1), LCK(1), MAP2K1(1), MAP2K4(1), MAP3K1(3), MAPK3(3), MAPK8(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), NFKB1(1), NFKBIA(2), PIK3R1(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKCA(1), PTPN7(1), RAC1(1), RAF1(1), RASA1(4), RELA(2), SOS1(5), SYT1(2), VAV1(2), ZAP70(1) 8726678 72 52 72 19 37 4 13 9 9 0 0.387 1.000 1.000 384 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 66 ACAA1(1), ACOX1(1), ACOX2(2), ACOX3(3), ACSL1(1), ACSL5(1), ACSL6(2), ANGPTL4(3), APOA2(1), APOA5(1), AQP7(2), CD36(1), CPT1A(2), CPT1B(2), CPT1C(2), CYP27A1(2), CYP4A11(2), CYP4A22(4), CYP7A1(4), CYP8B1(1), DBI(2), EHHADH(1), FADS2(1), GK2(3), LPL(1), ME1(2), PCK1(3), PDPK1(1), PLTP(1), PPARD(1), PPARG(3), RXRG(5), SCD(1), SCP2(2), SLC27A1(1), SLC27A2(4), SLC27A4(1), SLC27A5(4), SLC27A6(3), SORBS1(4), UCP1(2) 12473191 84 51 84 25 49 2 18 8 7 0 0.364 1.000 1.000 385 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 61 APAF1(1), ATM(19), ATR(3), BAI1(1), BAX(1), CASP3(1), CASP8(4), CASP9(3), CCNB1(1), CCNB3(5), CCND1(1), CCNE2(1), CDK2(1), CDK4(2), CDK6(1), CHEK1(1), CHEK2(5), DDB2(4), GADD45A(1), GTSE1(2), LRDD(6), PERP(1), PTEN(5), RCHY1(1), RFWD2(2), RRM2(2), SERPINB5(1), SERPINE1(2), SESN1(2), SESN3(2), SFN(1), STEAP3(1), TP53I3(2), TP73(2), TSC2(2), ZMAT3(1) 12171682 91 51 91 31 50 2 17 7 15 0 0.847 1.000 1.000 386 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(1), CPEB1(3), EGFR(3), ERBB2(11), ERBB4(3), ETS1(2), ETV6(4), ETV7(1), FMN2(7), MAP2K1(1), MAPK3(3), NOTCH1(5), NOTCH2(5), NOTCH3(3), NOTCH4(4), PIWIL1(4), PIWIL3(3), PIWIL4(4), RAF1(1), SOS1(5), SOS2(4), SPIRE2(3) 10112030 80 51 79 24 39 0 23 9 9 0 0.588 1.000 1.000 387 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ACCN1(2), ADCY4(2), ADCY6(4), ADCY8(5), CACNA1A(6), CACNA1B(2), GNAS(4), GNB1(5), GNB3(3), GRM4(1), ITPR3(4), KCNB1(3), PDE1A(2), PLCB2(1), PRKACB(1), PRKX(1), SCNN1A(4), SCNN1B(1), SCNN1G(1), TAS1R1(2), TAS1R3(5), TAS2R1(1), TAS2R13(1), TAS2R16(1), TAS2R39(1), TAS2R40(2), TAS2R43(1), TAS2R50(3), TAS2R60(1), TAS2R9(3), TRPM5(4) 10962344 77 51 75 35 40 5 19 8 5 0 0.709 1.000 1.000 388 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 43 CBL(4), CSK(4), DAG1(1), EPHB2(3), GRAP2(2), ITK(2), ITPKA(2), ITPKB(1), LAT(1), LCK(1), NCK1(1), NFAT5(7), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), NFKBIL2(2), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PAK7(2), PLCG1(3), PTPRC(5), RAF1(1), RASGRP1(1), RASGRP2(2), RASGRP3(2), SOS1(5), SOS2(4), VAV1(2), ZAP70(1) 10461850 79 51 79 17 43 3 13 8 12 0 0.138 1.000 1.000 389 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 35 BTK(3), CALM1(1), CALM2(1), FCER1A(2), FOS(3), LYN(2), MAP2K1(1), MAP2K4(1), MAP2K7(2), MAP3K1(3), MAPK3(3), MAPK8(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), PAK2(1), PIK3R1(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), RAF1(1), SOS1(5), SYK(1), SYT1(2), VAV1(2) 7807120 66 50 66 16 32 4 11 12 7 0 0.326 1.000 1.000 390 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASS(3), ACAT1(1), AKR1B10(1), ALDH3A1(2), ALDH9A1(2), BBOX1(1), DLST(1), DOT1L(9), EHHADH(1), EHMT1(2), EHMT2(4), GCDH(2), HADH(1), HADHA(3), HSD17B10(1), HSD17B4(3), HSD3B7(1), NSD1(7), OGDH(5), OGDHL(4), PIPOX(2), PLOD1(1), PLOD2(3), RDH13(1), SETD1A(3), SETDB1(4), SHMT1(1), TMLHE(1) 11209014 70 50 70 42 41 2 10 8 9 0 0.999 1.000 1.000 391 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), AGPAT2(1), AGPAT3(2), AKR1B1(1), ALDH3A1(2), ALDH9A1(2), CEL(2), DAK(1), DGAT1(1), DGKA(1), DGKB(2), DGKD(3), DGKE(1), DGKG(4), DGKH(2), DGKI(5), DGKQ(2), DGKZ(3), GK2(3), GLA(1), GLB1(2), LCT(4), LIPA(1), LIPC(5), LIPG(2), LPL(1), MGLL(1), PNLIP(3), PNLIPRP1(4), PNPLA3(2), PPAP2A(5), PPAP2B(1), PPAP2C(1) 11310718 79 50 79 30 46 3 14 7 9 0 0.646 1.000 1.000 392 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP4(1), BMP5(1), BMP6(1), BMP8B(1), CSNK1A1(3), CSNK1A1L(1), CSNK1E(1), CSNK1G1(3), CSNK1G2(1), CSNK1G3(1), FBXW11(1), GLI1(4), GLI2(4), GLI3(10), HHIP(4), IHH(2), LRP2(12), PRKACB(1), PRKX(1), PTCH1(8), PTCH2(1), RAB23(1), SMO(2), STK36(5), WNT2(2), WNT3A(1), WNT5A(1), WNT6(1), WNT7A(2), WNT7B(1), WNT8A(1), ZIC2(3) 11716731 82 50 82 34 31 3 31 5 12 0 0.891 1.000 1.000 393 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT3(1), ARHGEF11(3), DLG4(3), GNA13(5), LPA(7), MAP2K4(1), MAP3K1(3), MAP3K5(4), MAPK8(4), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), NFKBIL2(2), PHKA2(1), PIK3CB(5), PLD1(3), PLD2(1), PLD3(3), PTK2(3), RDX(2), ROCK1(4), ROCK2(6), SERPINA4(1) 9477595 75 50 74 24 38 2 15 7 13 0 0.751 1.000 1.000 394 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 72 AKT3(1), BTK(3), FCER1A(2), FYN(1), GAB2(1), INPP5D(2), LAT(1), LYN(2), MAP2K1(1), MAP2K3(2), MAP2K4(1), MAP2K7(2), MAPK10(1), MAPK11(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK8(4), MAPK9(5), MS4A2(3), NRAS(2), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), PLCG1(3), PLCG2(3), PRKCA(1), PRKCD(1), RAC1(1), RAF1(1), SOS1(5), SOS2(4), SYK(1), VAV1(2), VAV2(1), VAV3(2) 13422020 89 49 89 38 39 2 18 19 11 0 0.955 1.000 1.000 395 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(3), CALM1(1), CALM2(1), CHRM1(1), FLT1(1), FLT4(1), KDR(9), NOS3(6), PDE2A(1), PDE3A(5), PDE3B(1), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKG1(1), PRKG2(4), RYR2(21), SLC7A1(4), SYT1(2), TNNI1(2) 7781154 71 49 71 31 34 2 18 7 10 0 0.923 1.000 1.000 396 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 47 AKT3(1), BRD4(2), CAP1(5), CBL(4), GSK3A(1), INPPL1(2), IRS1(3), IRS2(3), IRS4(8), LNPEP(1), MAPK3(3), PARD3(6), PARD6A(3), PIK3CD(3), PIK3R1(2), PTEN(5), RAF1(1), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), SERPINB6(2), SFN(1), SLC2A4(1), SORBS1(4), SOS1(5), SOS2(4), YWHAB(2), YWHAE(2), YWHAQ(1), YWHAZ(3) 10994798 84 49 84 28 44 3 16 7 14 0 0.784 1.000 1.000 397 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 38 AKT3(1), BLNK(1), BTK(3), CD19(2), CSK(4), DAG1(1), EPHB2(3), ITPKA(2), ITPKB(1), LYN(2), MAP2K1(1), NFAT5(7), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), NFKBIL2(2), PIK3CD(3), PIK3R1(2), PLCG2(3), PPP1R13B(3), RAF1(1), SERPINA4(1), SOS1(5), SOS2(4), SYK(1), VAV1(2) 9784331 68 49 68 21 37 1 14 7 9 0 0.537 1.000 1.000 398 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ABP1(3), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2), AOC3(1), AOX1(2), CAT(3), CYP1A1(1), CYP1A2(2), CYP2A13(3), CYP2A6(3), CYP2A7(3), CYP2B6(2), CYP2C18(1), CYP2C19(1), CYP2C9(2), CYP2D6(1), CYP2E1(1), CYP2F1(2), CYP3A4(5), CYP3A7(6), CYP4B1(3), CYP51A1(2), DDC(3), EHHADH(1), GCDH(2), HAAO(1), HADHA(3), KMO(1), MAOA(1), SDS(1), TDO2(1) 10636058 69 49 69 31 38 1 12 10 8 0 0.888 1.000 1.000 399 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 DLD(2), DUSP10(3), DUSP4(1), DUSP8(3), GAB1(2), GADD45A(1), MAP2K4(1), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K12(1), MAP3K13(6), MAP3K2(2), MAP3K4(5), MAP3K5(4), MAP3K7(3), MAP3K9(1), MAPK10(1), MAPK7(2), MAPK8(4), MAPK9(5), MYEF2(2), NFATC3(2), NR2C2(2), PAPPA(4), TRAF6(1), ZAK(1) 9560900 65 48 65 26 28 1 19 6 11 0 0.948 1.000 1.000 400 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT3(1), ASAH1(2), BRAF(1), DAG1(1), EGFR(3), EPHB2(3), ITPKA(2), ITPKB(1), ITPR1(7), ITPR2(9), ITPR3(4), KCNJ3(1), KCNJ5(1), PIK3CB(5), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), RAF1(1), SOS1(5), SOS2(4), SRC(4), TERF2IP(2) 11325403 70 47 69 32 37 3 16 7 7 0 0.945 1.000 1.000 401 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(19), ATR(3), BRCA1(4), BRCA2(17), CHEK1(1), CHEK2(5), FANCA(5), FANCC(2), FANCD2(10), FANCE(2), FANCF(2), FANCG(2), HUS1(1), MRE11A(2), RAD1(1), RAD17(1), RAD50(6), RAD51(3) 8345561 86 46 86 23 44 5 11 9 17 0 0.751 1.000 1.000 402 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(1), BIRC3(1), CASP3(1), CASP6(1), CASP8(4), CASP9(3), CFLAR(1), CHUK(6), DFFA(4), FADD(1), GAS2(2), LMNA(1), MAP3K14(2), NFKB1(1), NFKBIA(2), RELA(2), RIPK1(2), SPTAN1(34), TNFRSF10A(4), TNFRSF25(3), TNFSF10(2), TRADD(1), TRAF2(2) 6462866 81 46 81 22 47 1 14 3 16 0 0.505 1.000 1.000 403 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 22 IMPA1(1), INPP1(1), INPP4A(1), INPP4B(4), INPP5A(3), INPPL1(2), ITPKA(2), ITPKB(1), PIK3C2A(7), PIK3C2B(6), PIK3C2G(3), PIK3CB(5), PIK3CG(3), PLCB1(4), PLCB2(1), PLCB3(6), PLCB4(2), PLCD1(1), PLCG1(3), PLCG2(3) 8216324 59 46 58 26 28 0 14 6 11 0 0.944 1.000 1.000 404 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 41 CHUK(6), DAXX(1), EGF(4), EGFR(3), ETS1(2), FOS(3), IKBKB(4), MAP2K1(1), MAP2K3(2), MAP2K4(1), MAP2K7(2), MAP3K1(3), MAP3K14(2), MAP3K5(4), MAPK13(1), MAPK14(1), MAPK3(3), MAPK8(4), NFKB1(1), NFKBIA(2), PPP2CA(1), PRKCA(1), PRKCD(1), PRKCG(2), PRKCQ(1), RAF1(1), RELA(2), RIPK1(2), SP1(3), TNFRSF1B(3), TRAF2(2) 9414282 69 46 69 32 29 4 19 8 9 0 0.963 1.000 1.000 405 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(4), ACTR3(1), CFL2(1), FLNA(5), FLNC(5), FSCN1(1), FSCN2(2), GDI1(2), LIMK1(2), MYH2(5), MYLK(5), MYLK2(4), PAK2(1), PAK3(4), PAK4(1), PAK6(1), PAK7(2), PFN1(2), ROCK1(4), ROCK2(6), RPS4X(2), WASL(1) 9282557 61 46 61 23 30 0 13 9 9 0 0.771 1.000 1.000 406 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 36 EEF1A2(2), EEF1B2(1), EEF1D(1), EEF1G(2), EEF2(1), EEF2K(4), EIF2AK1(2), EIF2AK2(2), EIF2AK3(3), EIF2B1(1), EIF2B2(3), EIF2B4(2), EIF2B5(2), EIF2S3(2), EIF4A1(1), EIF4A2(3), EIF4E(1), EIF4EBP1(1), EIF4EBP2(1), EIF4G1(1), EIF4G3(9), EIF5A(1), EIF5B(6), ETF1(2), KIAA0664(4), PABPC3(3), SLC35A4(1) 8288768 62 46 61 22 31 2 12 7 10 0 0.915 1.000 1.000 407 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(7), AXIN1(3), CCND1(1), CREBBP(18), CSNK1A1(3), CSNK2A1(4), CTBP1(1), CTNNB1(4), HDAC1(1), MAP3K7(3), MYC(1), NLK(2), PPARD(1), PPP2CA(1), TLE1(4), WIF1(2) 5669390 56 46 55 18 21 2 13 4 16 0 0.785 1.000 1.000 408 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(1), BAX(1), BCL2L1(2), CASP1(2), CASP3(1), CASP4(2), CASP6(1), CASP8(4), CASP9(3), CD40(1), DAXX(1), DFFA(4), FADD(1), IKBKE(2), MCL1(1), NFKB1(1), NFKBIA(2), NGFR(3), NR3C1(1), NTRK1(4), PTPN13(7), RIPK1(2), SFRS2IP(2), TFG(4), TNFRSF1B(3), TRADD(1), TRAF2(2), TRAF6(1) 8380146 60 45 60 26 30 0 15 4 11 0 0.958 1.000 1.000 409 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 36 CALM1(1), CALM2(1), FPR1(1), GNA15(1), GNB1(5), MAP2K1(1), MAP2K3(2), MAP3K1(3), MAPK14(1), MAPK3(3), NCF2(4), NFATC1(4), NFATC2(6), NFATC3(2), NFATC4(1), NFKB1(1), NFKBIA(2), PIK3C2G(3), PLCB1(4), PPP3CA(4), PPP3CB(4), PPP3CC(2), RAC1(1), RAF1(1), RELA(2), SYT1(2) 7290681 62 45 62 15 29 6 11 10 6 0 0.292 1.000 1.000 410 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), AGPAT2(1), AGPAT3(2), AKR1B1(1), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2), CEL(2), DGAT1(1), DGKA(1), DGKB(2), DGKD(3), DGKE(1), DGKG(4), DGKH(2), DGKQ(2), DGKZ(3), GLA(1), GLB1(2), LCT(4), LIPC(5), LIPG(2), LPL(1), PNLIP(3), PNLIPRP1(4), PPAP2A(5), PPAP2B(1), PPAP2C(1) 9288337 69 45 69 31 40 2 11 7 9 0 0.876 1.000 1.000 411 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(4), AGPAT2(1), AGPAT3(2), AGPS(2), CDS1(2), CHAT(2), CHKA(1), CHKB(3), CPT1B(2), DGKA(1), DGKB(2), DGKD(3), DGKE(1), DGKG(4), DGKH(2), DGKQ(2), DGKZ(3), ETNK1(1), GPD1(1), GPD2(1), LCAT(1), LGALS13(2), PAFAH1B1(1), PAFAH2(1), PCYT1A(1), PISD(2), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), PLCB2(1), PLCG1(3), PLCG2(3), PPAP2A(5), PPAP2B(1), PPAP2C(1) 9642734 70 45 70 31 38 3 14 7 8 0 0.886 1.000 1.000 412 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 40 ALPI(2), ALPL(1), ASCC3(5), ATP13A2(5), DDX18(2), DDX19A(1), DDX23(3), DDX4(3), DDX47(2), DDX50(1), DDX51(1), DDX52(1), DDX54(4), DDX55(2), ENTPD7(2), EP400(7), ERCC3(2), FPGS(1), GCH1(1), IFIH1(3), MOV10L1(1), RAD54B(4), RAD54L(1), RUVBL2(1), SETX(5), SKIV2L2(2), SMARCA2(9), SMARCA5(1) 11829369 73 45 73 30 38 7 15 8 5 0 0.947 1.000 1.000 413 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 ABO(1), B3GALT4(4), B3GALT5(1), B3GNT1(1), B3GNT2(2), B3GNT4(1), B3GNT5(6), B4GALT1(1), B4GALT6(2), FUT1(2), FUT2(1), FUT3(1), FUT5(1), FUT9(1), GCNT2(1), PIGB(3), PIGC(1), PIGF(2), PIGG(6), PIGK(3), PIGL(1), PIGM(1), PIGN(1), PIGO(2), PIGS(2), PIGT(1), PIGU(1), PIGV(1), PIGZ(1), ST3GAL1(1), ST3GAL5(2), ST3GAL6(2), ST6GALNAC3(2), ST6GALNAC4(1), ST6GALNAC5(3), ST6GALNAC6(1), ST8SIA1(1), UGCG(1) 9353394 66 45 66 21 35 2 15 9 5 0 0.282 1.000 1.000 414 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(19), BMPR1B(2), CDK4(2), CDKN1B(5), CEBPB(3), DAZL(1), DMC1(1), EGR1(1), FSHR(1), INHA(1), LHCGR(2), MLH1(4), MSH5(3), NCOR1(13), NRIP1(4), PGR(1), PRLR(1), PTGER2(1), SMPD1(3), VDR(1) 6741023 69 45 69 24 31 2 12 8 16 0 0.851 1.000 1.000 415 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 56 APC(7), AXIN1(3), CCND1(1), CSNK1E(1), CTNNB1(4), DVL2(2), DVL3(1), FOSL1(1), FZD10(1), FZD3(3), FZD6(4), FZD7(2), FZD8(1), FZD9(2), LDLR(2), MAPK10(1), MAPK9(5), MYC(1), PAFAH1B1(1), PLAU(1), PPP2R5E(2), PRKCA(1), PRKCD(1), PRKCG(2), PRKCI(1), PRKCQ(1), PRKCZ(2), PRKD1(2), RAC1(1), SFRP4(2), WNT2(2), WNT5A(1), WNT6(1), WNT7A(2), WNT7B(1) 11446427 66 45 66 32 30 5 15 5 11 0 0.978 1.000 1.000 416 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 24 BRCA1(4), CARM1(2), CCND1(1), CREBBP(18), ERCC3(2), GRIP1(1), GTF2A1(1), GTF2E1(1), GTF2F1(1), HDAC1(1), HDAC2(1), HDAC4(2), HDAC5(2), HDAC6(2), MEF2C(2), NCOR2(10), NRIP1(4), PELP1(2) 7937007 57 44 56 19 21 1 19 4 12 0 0.671 1.000 1.000 417 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(1), AKR1D1(2), ARSD(2), CARM1(2), CYP11B2(3), HSD17B1(1), HSD17B3(1), HSD17B8(3), HSD3B1(2), HSD3B2(3), LCMT2(1), METTL2B(1), PRMT5(3), PRMT6(1), PRMT7(5), PRMT8(4), SRD5A1(1), SRD5A2(1), STS(2), SULT2A1(1), SULT2B1(1), UGT1A1(3), UGT1A3(3), UGT1A5(1), UGT1A6(1), UGT1A9(2), UGT2A1(1), UGT2A3(3), UGT2B10(2), UGT2B28(2), UGT2B4(2), UGT2B7(1), WBSCR22(3) 9664217 65 44 64 20 32 5 14 12 2 0 0.433 1.000 1.000 418 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(1), CANX(1), CD4(1), CD8A(2), CIITA(2), CTSB(1), CTSL1(1), CTSS(1), HLA-A(5), HLA-C(2), HLA-DMB(1), HLA-DQA1(1), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(1), HLA-DRB1(1), HLA-E(1), HLA-F(1), HSP90AA1(8), HSP90AB1(4), HSPA5(1), IFNA16(1), IFNA4(3), KIR2DL1(1), KIR2DL3(1), KIR3DL1(2), KLRC4(2), KLRD1(1), NFYA(1), PDIA3(3), PSME1(1), RFX5(1), RFXANK(1), TAP1(1), TAP2(1), TAPBP(1) 8924652 60 44 59 27 27 2 11 6 14 0 0.929 1.000 1.000 419 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(3), COL4A2(5), COL4A3(5), COL4A4(4), COL4A5(2), COL4A6(1), F10(1), F11(3), F12(1), F2R(2), F5(9), F8(5), F9(1), FGA(7), FGB(1), FGG(3), KLKB1(1), PROS1(4), SERPINC1(1), SERPING1(1) 8526258 60 44 59 21 33 1 19 2 5 0 0.936 1.000 1.000 420 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 39 ALK(1), ESRRA(2), HNF4A(1), NR1D1(3), NR1D2(3), NR1H2(4), NR1I2(1), NR1I3(2), NR2C2(2), NR2F1(2), NR2F2(2), NR3C1(1), NR4A1(1), NR4A2(2), PGR(1), PPARD(1), PPARG(3), RARA(3), RARB(4), RARG(11), ROR1(2), RORA(1), RORC(2), RXRG(5), VDR(1) 7924695 61 44 61 22 30 2 10 7 12 0 0.675 1.000 1.000 421 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 31 AKT3(1), BTK(3), CD19(2), GAB1(2), ITPR1(7), ITPR2(9), ITPR3(4), LYN(2), PHF11(1), PLCG2(3), PPP1R13B(3), PREX1(3), PTEN(5), PTPRC(5), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), SYK(1), TEC(4), VAV1(2) 10126312 63 44 63 21 36 3 10 5 9 0 0.562 1.000 1.000 422 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(1), AKR1B10(1), ALDOA(2), FBP1(1), FPGT(5), FUK(2), GMDS(3), GMPPA(1), GMPPB(2), HK1(3), HK2(3), HK3(3), HSD3B7(1), LHPP(2), MPI(2), MTMR1(2), MTMR2(3), MTMR6(4), PFKFB1(2), PFKFB2(2), PFKFB3(3), PFKP(1), PGM2(1), PMM1(3), PMM2(1), RDH13(1), TSTA3(1) 7200946 56 43 56 24 37 1 7 3 8 0 0.757 1.000 1.000 423 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(6), ATP5O(1), ATP6V0A1(6), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(3), ATP6V1B1(6), ATP6V1C1(3), ATP6V1E1(1), ATP6V1G2(1), ATP6V1H(4), ATP7A(2), ATP7B(1), COX10(2), COX5A(1), COX6A1(3), COX6A2(1), COX6C(1), COX7A1(1), COX8A(1), NDUFA5(1), NDUFA8(1), NDUFB5(1), NDUFB6(1), NDUFS1(2), NDUFS2(1), NDUFV1(2), SDHA(3), SHMT1(1), UQCRB(1), UQCRH(1) 7385928 63 43 61 16 31 4 16 7 5 0 0.217 1.000 1.000 424 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(1), F11(3), F12(1), F13B(1), F5(9), F8(5), F9(1), FGA(7), FGB(1), FGG(3), LPA(7), PLAT(1), PLAU(1), SERPINB2(1), SERPINE1(2), VWF(7) 6796099 51 42 51 15 28 1 16 2 4 0 0.524 1.000 1.000 425 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 CEBPB(3), CLDN5(1), CLOCK(1), CRY1(1), CRY2(3), DAZAP2(2), DNAJA1(1), EIF4G2(5), ETV6(4), GFRA1(2), GSTM3(1), GSTP1(2), HERPUD1(1), HSPA8(2), NCKAP1(5), NCOA4(2), NR1D2(3), PER1(3), PER2(1), PIGF(2), PPP1R3C(1), PURA(1), SF3A3(2), TOB1(4), TUBB3(5), UGP2(5), VAPA(2), ZFR(1) 7043852 66 42 65 17 36 3 13 4 10 0 0.542 1.000 1.000 426 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(13), ACACB(5), ACAT1(1), ACSS1(1), AKR1B1(1), ALDH3A1(2), ALDH9A1(2), DLAT(1), DLD(2), GLO1(1), GRHPR(1), HAGH(1), LDHAL6A(1), LDHAL6B(1), LDHD(2), MDH1(1), ME1(2), ME2(1), ME3(1), PC(2), PCK1(3), PDHA2(2), PKLR(1), PKM2(2) 9052196 50 42 49 21 27 0 10 3 10 0 0.871 1.000 1.000 427 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 33 ACTA1(3), DOCK1(4), FOS(3), GAB1(2), HGF(1), ITGA1(1), ITGB1(1), MAP2K1(1), MAP4K1(3), MAPK3(3), MAPK8(4), MET(5), PIK3R1(2), PTEN(5), PTK2(3), PTK2B(3), RAF1(1), RAP1A(1), RAP1B(2), RASA1(4), SOS1(5), SRC(4) 8001536 61 42 61 18 35 2 12 6 6 0 0.585 1.000 1.000 428 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR3(1), ARHGAP1(1), ARHGAP5(8), ARHGAP6(4), ARHGEF1(6), ARHGEF11(3), ARHGEF5(2), ARPC2(3), ARPC4(1), DIAPH1(2), LIMK1(2), MYL2(2), MYLK(5), PFN1(2), PIP5K1A(5), PPP1R12B(2), ROCK1(4), SRC(4), TLN1(2), VCL(1) 8757657 60 42 60 15 37 0 11 5 7 0 0.285 1.000 1.000 429 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(1), APC(7), ASAH1(2), DAG1(1), DLG4(3), EPHB2(3), GNAI1(1), ITPR1(7), ITPR2(9), ITPR3(4), KCNJ3(1), KCNJ5(1), PTX3(1), RAC1(1), RYR1(12) 8882824 54 42 54 21 27 3 8 6 10 0 0.729 1.000 1.000 430 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(5), CDC7(1), CDK2(1), CDT1(2), DIAPH2(4), MCM10(1), MCM2(1), MCM3(1), MCM4(4), MCM6(2), NACA(1), ORC1L(1), ORC3L(3), PCNA(1), POLA2(3), POLD1(3), POLD2(3), POLD3(3), POLE(6), POLE2(1), RFC1(3), RFC4(4), RPA3(3), RPS27A(1), UBA52(1), UBB(2) 9800033 61 41 61 21 36 0 12 6 7 0 0.703 1.000 1.000 431 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 AK3L1(1), CAD(7), CTPS(1), DCK(1), DCTD(1), DPYD(5), DPYS(5), DUT(1), NT5E(3), POLD1(3), POLD2(3), POLE(6), POLQ(8), POLR1B(1), POLR2B(1), POLR2C(2), POLR2D(1), POLR2E(1), POLR2F(1), POLRMT(2), RRM1(1), RRM2(2), TK1(1), TXNRD1(3), TYMS(1), UMPS(1), UPB1(3) 11097581 66 41 66 22 41 0 8 11 6 0 0.568 1.000 1.000 432 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 33 APC(7), ASAH1(2), BRAF(1), CCL13(1), CCL15(1), CCL16(1), DAG1(1), EGFR(3), GNA15(1), GNAI1(1), ITPKA(2), ITPKB(1), ITPR1(7), ITPR2(9), ITPR3(4), KCNJ3(1), KCNJ5(1), MAPK10(1), MAPK14(1), PHKA2(1), PIK3CD(3), PIK3R1(2), PTX3(1), RAF1(1), SRC(4) 9896020 58 41 58 22 29 2 11 6 10 0 0.760 1.000 1.000 433 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 27 BAG4(1), CASP3(1), CASP8(4), DFFA(4), FADD(1), LMNA(1), LMNB1(2), LMNB2(1), MADD(1), MAP2K4(1), MAP3K1(3), MAP3K7(3), MAPK8(4), PAK2(1), PRKDC(10), RIPK1(2), SPTAN1(34), TRADD(1), TRAF2(2) 7138236 77 41 77 28 43 4 11 6 13 0 0.925 1.000 1.000 434 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CHUK(6), FOS(3), IKBKB(4), LY96(1), MAP2K3(2), MAP2K4(1), MAP3K1(3), MAP3K14(2), MAP3K7(3), MAPK14(1), MAPK8(4), MYD88(1), NFKB1(1), NFKBIA(2), RELA(2), TLR10(4), TLR2(2), TLR3(2), TLR4(3), TLR6(2), TLR7(6), TLR9(2), TOLLIP(1), TRAF6(1) 7040216 59 41 59 18 28 2 11 5 13 0 0.602 1.000 1.000 435 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 17 ABL1(4), ATM(19), BRCA1(4), CHEK1(1), CHEK2(5), GADD45A(1), MAPK8(4), MRE11A(2), NFKB1(1), NFKBIA(2), RAD50(6), RAD51(3), RBBP8(2), RELA(2), TP73(2) 5528730 58 40 58 17 30 1 11 6 10 0 0.842 1.000 1.000 436 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 26 CASP3(1), CASP6(1), CASP8(4), CFLAR(1), DAXX(1), DFFA(4), FADD(1), FAF1(1), LMNA(1), LMNB1(2), LMNB2(1), MAP2K4(1), MAP3K1(3), MAP3K7(3), MAPK8(4), PAK2(1), PRKDC(10), PTPN13(7), RIPK2(1), SPTAN1(34) 7481139 82 40 82 33 47 4 12 4 15 0 0.989 1.000 1.000 437 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(1), CARS2(3), DARS(2), DARS2(3), EARS2(1), EPRS(5), FARSA(1), FARSB(2), GARS(1), IARS2(2), KARS(3), LARS(1), LARS2(1), MTFMT(1), NARS(1), NARS2(2), QARS(3), RARS(1), RARS2(2), SARS(2), SARS2(2), TARS2(8), VARS(3), VARS2(4), YARS(3), YARS2(1) 10493955 59 40 58 19 37 4 12 3 3 0 0.581 1.000 1.000 438 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 31 ACTR3(1), DAG1(1), DGKA(1), ITGA9(3), ITPKA(2), ITPKB(1), ITPR1(7), ITPR2(9), ITPR3(4), MAP2K1(1), MAPK3(3), NR1I3(2), PDE3A(5), PDE3B(1), PIK3C2G(3), PIK3CD(3), PIK3R1(2), PLDN(2), PSME1(1), RIPK3(1), RPS4X(2), SGCB(1) 8976943 56 40 56 28 32 3 7 6 8 0 0.970 1.000 1.000 439 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 36 AGT(1), AGTR2(1), CALM1(1), CALM2(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), CDK5(1), FYN(1), GNAI1(1), GNB1(5), JAK2(2), MAP2K1(1), MAPK14(1), MAPK3(3), MAPK8(4), MAPT(5), MYLK(5), PLCG1(3), PRKCA(1), PTK2B(3), RAF1(1), SOS1(5), STAT1(4), SYT1(2) 7961527 58 39 58 18 32 2 7 10 7 0 0.549 1.000 1.000 440 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(2), POLA2(3), POLD1(3), POLD2(3), POLD3(3), POLE(6), POLE2(1), POLG2(3), POLH(2), POLI(2), POLK(6), POLM(2), POLQ(8), PRIM2(2), REV1(2), REV3L(10) 7805948 58 39 58 16 33 1 8 6 10 0 0.635 1.000 1.000 441 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(4), ADCY3(2), ADCY9(3), ARF3(1), ATP6V0A1(6), ATP6V0A2(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V0E1(1), ATP6V1A(3), ATP6V1C1(3), ATP6V1E1(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1H(4), GNAS(4), PDIA4(1), PLCG1(3), PLCG2(3), PRKCA(1), SEC61A2(1), TRIM23(2) 7154229 50 39 50 17 26 3 8 6 7 0 0.544 1.000 1.000 442 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 21 CHUK(6), CREBBP(18), IKBKB(4), IL1B(1), IL8(1), MAP2K3(2), MAP3K14(2), MAP3K7(3), MAPK11(2), MAPK14(1), MYD88(1), NFKB1(1), NFKBIA(2), NR3C1(1), RELA(2), TGFBR2(3), TLR2(2) 4774202 52 39 51 14 23 1 12 1 15 0 0.462 1.000 1.000 443 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(13), ACAT1(1), AKR1B1(1), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2), DLAT(1), DLD(2), GLO1(1), GRHPR(1), HAGH(1), LDHD(2), MDH1(1), ME1(2), ME2(1), ME3(1), PC(2), PCK1(3), PDHA2(2), PKLR(1), PKM2(2) 7144639 45 39 45 21 25 0 9 2 9 0 0.947 1.000 1.000 444 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 APAF1(1), BAX(1), BCL2L1(2), BIRC3(1), CASP3(1), CASP6(1), CASP8(4), CASP9(3), FADD(1), MAP2K4(1), MAP3K1(3), MAP3K14(2), MAPK10(1), MCL1(1), MYC(1), NFKB1(1), NFKBIA(2), PARP1(5), PRF1(4), RELA(2), RIPK1(2), TNFRSF1B(3), TNFSF10(2), TRADD(1), TRAF2(2) 7077139 48 38 48 21 20 2 15 5 6 0 0.938 1.000 1.000 445 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 29 CABIN1(3), CALM1(1), CALM2(1), HDAC5(2), IGF1R(5), INSR(4), MAPK14(1), MAPK7(2), MEF2A(1), MEF2C(2), MEF2D(1), MYOD1(1), NFATC1(4), NFATC2(6), PIK3R1(2), PPP3CA(4), PPP3CB(4), PPP3CC(2), SYT1(2) 6287604 48 38 48 20 17 3 12 7 9 0 0.869 1.000 1.000 446 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 13 APC(7), AXIN1(3), CREBBP(18), CTNNB1(4), HDAC1(1), LDB1(2), LEF1(2), TRRAP(10) 5460557 47 38 46 16 16 1 13 4 13 0 0.713 1.000 1.000 447 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 31 MAP2K4(1), MAP2K7(2), MAPK10(1), MAPK11(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK8(4), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(3), MAPK9(5), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), NFKBIL2(2), PIK3CD(3), PIK3R1(2), SYT1(2), TRAF2(2), TRAF6(1) 6083103 53 38 53 20 25 2 13 6 7 0 0.753 1.000 1.000 448 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 APC(7), AXIN1(3), BMP4(1), BMP5(1), BMPR1A(1), BMPR2(5), CHRD(5), CTNNB1(4), MAP3K7(3), MEF2C(2), MYL2(2), NOG(1), NPPB(1), RFC1(3), TGFB3(1), TGFBR2(3), TGFBR3(7) 7033970 50 37 50 17 29 0 8 4 9 0 0.823 1.000 1.000 449 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 28 EGFR(3), GNAS(4), GNB1(5), IGF1R(5), ITGB1(1), KLK2(1), MAP2K1(1), MAPK3(3), MKNK1(1), MYC(1), NGFR(3), PDGFRA(7), PPP2CA(1), PTPRR(1), RAF1(1), RPS6KA1(1), RPS6KA5(3), SOS1(5), SRC(4) 6330656 51 37 51 14 26 3 13 8 1 0 0.385 1.000 1.000 450 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH3B1(2), ALDH9A1(2), ALDOA(2), DLAT(1), DLD(2), ENO1(2), ENO2(1), ENO3(1), FBP1(1), GPI(3), HK1(3), HK2(3), HK3(3), PDHA2(2), PFKP(1), PGAM1(1), PGM1(2), PKLR(1), PKM2(2) 9450979 48 37 48 32 27 0 11 3 7 0 0.997 1.000 1.000 451 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH3B1(2), ALDH9A1(2), ALDOA(2), DLAT(1), DLD(2), ENO1(2), ENO2(1), ENO3(1), FBP1(1), GPI(3), HK1(3), HK2(3), HK3(3), PDHA2(2), PFKP(1), PGAM1(1), PGM1(2), PKLR(1), PKM2(2) 9450979 48 37 48 32 27 0 11 3 7 0 0.997 1.000 1.000 452 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(1), ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), ALDH3A1(2), ALDH3B1(2), ALDH9A1(2), ALDOA(2), DLAT(1), DLD(2), ENO1(2), ENO2(1), ENO3(1), FBP1(1), GALM(2), GAPDHS(1), GPI(3), HK1(3), HK2(3), HK3(3), LDHAL6A(1), LDHAL6B(1), PDHA2(2), PFKP(1), PGAM1(1), PGM1(2), PKLR(1), PKM2(2) 11262038 51 37 51 39 29 0 12 2 8 0 1.000 1.000 1.000 453 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(3), AKR1B10(1), ALAS1(5), AMT(1), AOC3(1), CHKA(1), CHKB(3), CTH(2), DLD(2), DMGDH(2), GARS(1), GATM(1), GLDC(4), HSD3B7(1), MAOA(1), PIPOX(2), PISD(2), PSAT1(1), PSPH(3), RDH13(1), SARS(2), SARS2(2), SDS(1), SHMT1(1), TARS2(8) 8242557 52 37 52 21 27 3 11 4 7 0 0.757 1.000 1.000 454 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 ALOX12B(2), ALOX15(2), ALOX5(2), CYP2B6(2), CYP2C18(1), CYP2C19(1), CYP2C9(2), CYP2E1(1), CYP2U1(1), CYP4A11(2), CYP4A22(4), CYP4F2(4), CYP4F3(2), EPHX2(2), GGT1(1), GPX3(2), GPX6(2), LTA4H(1), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), PTGES2(2), PTGIS(1), PTGS2(2), TBXAS1(3) 7513504 50 37 50 20 26 1 12 4 7 0 0.620 1.000 1.000 455 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2B(2), CAMK2D(1), CAMK2G(3), DAG1(1), ITPKA(2), ITPKB(1), ITPR1(7), ITPR2(9), ITPR3(4), NFAT5(7), PDE6A(1), PDE6B(1), PDE6C(2), PDE6G(1), PDE6H(1), SLC6A13(1) 6918933 44 37 44 16 24 3 8 3 6 0 0.685 1.000 1.000 456 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 19 ATM(19), ATR(3), BRCA1(4), CCNB1(1), CDC25A(1), CDKN2D(1), CHEK1(1), CHEK2(5), GADD45A(1), MYT1(3), PRKDC(10), RPS6KA1(1), WEE1(2), YWHAQ(1) 6900815 53 36 53 23 26 4 11 5 7 0 0.987 1.000 1.000 457 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ADC(1), ALDH4A1(1), CAD(7), CPS1(4), EARS2(1), EPRS(5), GAD1(5), GCLC(1), GCLM(1), GFPT1(1), GFPT2(1), GLS(1), GLS2(1), GLUD1(2), GLUD2(3), GMPS(2), GNPNAT1(1), GSR(2), GSS(1), NADSYN1(3), NAGK(2), PPAT(2), QARS(3) 7640218 51 36 51 24 28 1 12 4 6 0 0.941 1.000 1.000 458 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(1), ACY3(3), ADSL(1), ADSS(2), ASL(3), ASPA(2), ASRGL1(1), ASS1(2), CAD(7), CRAT(5), DARS(2), DARS2(3), DLAT(1), DLD(2), GAD1(5), NARS(1), NARS2(2), PC(2), PDHA2(2) 7322026 47 36 47 19 26 1 11 5 4 0 0.792 1.000 1.000 459 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(1), ALAS1(5), BLVRA(1), COX10(2), COX15(1), CP(1), EARS2(1), EPRS(5), FECH(1), FTH1(3), GUSB(1), HCCS(1), HMOX2(1), MMAB(1), PPOX(4), UGT1A1(3), UGT1A3(3), UGT1A5(1), UGT1A6(1), UGT1A9(2), UGT2A1(1), UGT2A3(3), UGT2B10(2), UGT2B28(2), UGT2B4(2), UGT2B7(1), UROD(1), UROS(2) 8101375 53 36 53 15 25 2 10 6 10 0 0.484 1.000 1.000 460 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(1), AKT3(1), DAG1(1), ITPKA(2), ITPKB(1), ITPR1(7), ITPR2(9), ITPR3(4), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), NFKBIL2(2), PHKA2(1), PIK3CB(5), PLD1(3), PLD2(1), PLD3(3) 8687058 54 36 54 25 30 2 11 2 9 0 0.928 1.000 1.000 461 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(3), ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), ALDH3A1(2), ALDH3B1(2), AOC3(1), AOX1(2), COMT(2), DBH(3), DCT(3), DDC(3), GSTZ1(1), HPD(2), MAOA(1), TPO(9), TYR(3) 6114589 45 36 45 15 18 0 18 6 3 0 0.466 1.000 1.000 462 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP5(3), ACPP(5), ACPT(3), ALPI(2), ALPL(1), CYP1A1(1), CYP1A2(2), CYP2A13(3), CYP2A6(3), CYP2A7(3), CYP2B6(2), CYP2C18(1), CYP2C19(1), CYP2C9(2), CYP2D6(1), CYP2E1(1), CYP2F1(2), CYP3A4(5), CYP3A7(6), CYP4B1(3), CYP51A1(2), PON1(1) 5656467 53 35 52 26 31 2 8 5 7 0 0.863 1.000 1.000 463 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(1), ACAA2(1), ACAD8(1), ACAD9(1), ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), AKR1B10(1), AKR1C4(1), AKR1D1(2), ALDH3A1(2), ALDH9A1(2), BAAT(1), CEL(2), CYP27A1(2), CYP7A1(4), HADHB(2), HSD3B7(1), LIPA(1), RDH13(1), SLC27A5(4), SOAT1(4), SRD5A1(1), SRD5A2(1) 6119347 44 35 44 14 28 1 7 3 5 0 0.364 1.000 1.000 464 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(3), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH4A1(1), ALDH9A1(2), AOC3(1), ARG2(1), ASL(3), CKMT2(2), CPS1(4), GATM(1), GLUD1(2), MAOA(1), NOS1(4), NOS3(6), ODC1(1), P4HA1(1), P4HA3(1), P4HB(3), PYCR1(3), RARS(1) 8547023 46 34 46 18 25 0 11 5 5 0 0.721 1.000 1.000 465 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(3), ALAS1(5), AMT(1), AOC3(1), CHKA(1), CHKB(3), CPT1B(2), CTH(2), DLD(2), DMGDH(2), GARS(1), GATM(1), GLDC(4), MAOA(1), PISD(2), PLCB2(1), PLCG1(3), PLCG2(3), PSPH(3), SARS(2), SHMT1(1) 8106773 44 34 44 15 20 2 13 3 6 0 0.532 1.000 1.000 466 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(2), ALG13(1), ALG2(2), ALG6(1), ALG9(1), B4GALT1(1), DHDDS(3), DOLPP1(1), DPM1(1), FUT8(5), GANAB(8), MAN1A1(3), MAN1A2(2), MAN1B1(5), MAN1C1(4), MAN2A1(5), MGAT1(4), MGAT2(1), MGAT3(1), MGAT4A(2), MGAT5B(1), ST6GAL1(1) 8150046 55 34 55 17 31 0 8 10 6 0 0.417 1.000 1.000 467 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(7), ASAH1(2), CASP3(1), CREB5(5), DAG1(1), EPHB2(3), FOS(3), ITPKA(2), ITPKB(1), MAP2K4(1), MAP2K7(2), MAPK10(1), MAPK8(4), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(3), MAPK9(5) 5514628 45 34 45 14 19 2 10 4 10 0 0.624 1.000 1.000 468 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(1), AKR1B10(1), B4GALT1(1), GAA(2), GALE(1), GALK1(1), GALT(1), GANC(3), GLA(1), GLB1(2), HK1(3), HK2(3), HK3(3), HSD3B7(1), LCT(4), MGAM(6), PFKP(1), PGM1(2), RDH13(1), UGP2(5) 7485376 43 33 42 25 25 1 7 4 6 0 0.966 1.000 1.000 469 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ACAA1(1), ACAA2(1), ACAT1(1), ALDH3A1(2), ALDH9A1(2), AOX1(2), AUH(1), BCAT1(1), BCAT2(1), BCKDHA(1), DBT(3), DLD(2), EHHADH(1), HADH(1), HADHA(3), HADHB(2), HMGCS1(1), HSD17B10(1), HSD17B4(3), IVD(1), MCCC1(5), MCCC2(2), MCEE(1), MUT(1), OXCT2(1) 8323222 41 33 41 11 26 1 6 2 6 0 0.443 1.000 1.000 470 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(1), GTF2A2(1), GTF2E1(1), GTF2E2(2), GTF2F1(1), GTF2H1(2), GTF2H3(1), GTF2I(2), GTF2IRD1(2), TAF1(2), TAF10(1), TAF12(2), TAF13(1), TAF1L(3), TAF2(3), TAF4(4), TAF4B(2), TAF5(1), TAF6(2), TAF6L(1), TAF7L(3), TAF9(1), TAF9B(1) 6957108 40 33 40 14 24 0 8 2 6 0 0.879 1.000 1.000 471 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 42 AKT3(1), BRAF(1), CAB39(1), DDIT4(1), EIF4EBP1(1), FIGF(1), HIF1A(1), MAPK3(3), PDPK1(1), PIK3CB(5), PIK3CD(3), PIK3CG(3), PIK3R1(2), PIK3R2(1), PRKAA2(4), RHEB(1), RICTOR(4), RPS6(3), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), RPS6KA6(2), TSC2(2), ULK1(3), ULK2(5), VEGFB(2), VEGFC(1) 9370613 58 33 58 24 27 3 14 7 7 0 0.917 1.000 1.000 472 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 32 BCL2L1(2), CBL(4), CFLAR(1), E2F1(1), FOS(3), IL2RA(1), IL2RB(2), IL2RG(3), IRS1(3), JAK1(3), JAK3(3), MAPK3(3), MYC(1), PIK3R1(2), PPIA(1), RAF1(1), SOS1(5), STAT5B(2), SYK(1) 6486353 42 33 42 20 21 2 8 5 6 0 0.946 1.000 1.000 473 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 34 ACTA1(3), ACTN1(2), ACTN2(3), ACTN3(2), CAPNS2(1), CSK(4), FYN(1), ITGA1(1), ITGB1(1), MAP2K1(1), MAPK3(3), MAPK8(4), PPP1R12B(2), PTK2(3), RAF1(1), RAP1A(1), ROCK1(4), SOS1(5), SRC(4), TLN1(2), VCL(1), ZYX(1) 9037722 50 33 50 20 33 3 7 4 3 0 0.848 1.000 1.000 474 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDH(4), AASS(3), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2), BBOX1(1), DLST(1), DOT1L(9), EHHADH(1), EHMT1(2), EHMT2(4), GCDH(2), HADHA(3), PLOD1(1), PLOD2(3), SDS(1), SHMT1(1), TMLHE(1) 7137961 45 33 45 29 27 1 5 5 7 0 0.998 1.000 1.000 475 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 17 CSF1(2), CSF1R(6), DDX20(2), E2F1(1), E2F4(1), ETS1(2), ETV3(1), FOS(3), HDAC2(1), HDAC5(2), NCOR2(10), RBL1(1), RBL2(3), SIN3A(4) 4955982 39 32 39 11 15 1 10 6 7 0 0.471 1.000 1.000 476 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(2), DLAT(1), DLD(2), ENO1(2), ENO2(1), ENO3(1), FBP1(1), GAPDHS(1), GPI(3), HK1(3), HK2(3), HK3(3), LDHAL6B(1), MDH1(1), PC(2), PCK1(3), PDHA2(2), PDHX(1), PFKP(1), PGAM1(1), PKLR(1), PKM2(2), TNFAIP1(1) 8224739 39 32 39 29 20 0 12 1 6 0 0.999 1.000 1.000 477 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(4), ACO1(1), ACO2(2), CLYBL(2), DLD(2), DLST(1), FH(3), IDH1(3), IDH3B(2), MDH1(1), OGDH(5), OGDHL(4), PC(2), PCK1(3), SDHA(3), SDHC(2), SUCLG1(1) 5778893 41 32 41 27 21 2 9 4 5 0 0.997 1.000 1.000 478 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(1), ARG2(1), ASL(3), ASS1(2), CKMT2(2), CPS1(4), EPRS(5), GATM(1), GLUD1(2), GLUD2(3), LAP3(1), NOS1(4), NOS3(6), P4HA1(1), P4HA3(1), PRODH(1), PYCR1(3), RARS(1), RARS2(2) 6953557 44 32 43 13 26 2 9 1 6 0 0.460 1.000 1.000 479 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 38 DAXX(1), HMGN1(2), HSPB2(2), MAP2K4(1), MAP3K1(3), MAP3K5(4), MAP3K7(3), MAP3K9(1), MAPK14(1), MAPKAPK2(1), MEF2A(1), MEF2C(2), MEF2D(1), MKNK1(1), MYC(1), RAC1(1), RIPK1(2), RPS6KA5(3), STAT1(4), TGFB3(1), TRADD(1), TRAF2(2) 6984287 39 32 39 16 21 3 8 2 5 0 0.911 1.000 1.000 480 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 17 CBL(4), EGF(4), EGFR(3), MAP2K1(1), MAPK3(3), PTPRB(5), RAF1(1), RASA1(4), SOS1(5), SPRY1(1), SPRY4(2), SRC(4) 4733879 37 32 37 11 21 1 10 3 2 0 0.596 1.000 1.000 481 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 ATF1(1), CREB5(5), DUSP10(3), EEF2K(4), EIF4E(1), GADD45A(1), MAP2K3(2), MAP2K4(1), MAP3K10(1), MAP3K4(5), MAP3K5(4), MAP3K7(3), MAPK11(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPKAPK2(1), MKNK1(1), MYEF2(2), NFKB1(1), NR2C2(2), TRAF6(1) 6452082 44 32 43 17 19 2 9 2 12 0 0.849 1.000 1.000 482 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 32 AGT(1), CALM1(1), CALM2(1), EGFR(3), MAP2K1(1), MAP2K4(1), MAP3K1(3), MAPK3(3), MAPK8(4), MEF2A(1), MEF2C(2), MEF2D(1), PRKCA(1), PTK2(3), PTK2B(3), RAC1(1), RAF1(1), SOS1(5), SRC(4), SYT1(2) 6377623 42 31 42 15 21 1 12 6 2 0 0.784 1.000 1.000 483 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 20 ARHGAP5(8), DIAPH1(2), FYN(1), ITGA1(1), ITGB1(1), MAP2K1(1), MAPK3(3), MYL2(2), MYLK(5), PFN1(2), PIK3R1(2), PTK2(3), RAF1(1), ROCK1(4), SRC(4), TLN1(2) 6708493 42 31 42 14 25 0 7 6 4 0 0.725 1.000 1.000 484 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 21 EIF4A1(1), EIF4A2(3), EIF4E(1), EIF4EBP1(1), EIF4G1(1), EIF4G2(5), EIF4G3(9), GHR(2), IRS1(3), MAPK14(1), MAPK3(3), MKNK1(1), PDK2(1), PDPK1(1), PIK3R1(2), PRKCA(1), PTEN(5) 5029356 41 31 41 21 19 2 6 5 9 0 0.997 1.000 1.000 485 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(3), GABBR1(2), GPRC5A(1), GPRC5D(1), GRM1(7), GRM2(5), GRM3(3), GRM4(1), GRM5(5), GRM7(4), GRM8(1) 4053491 33 31 32 15 16 0 12 2 3 0 0.660 1.000 1.000 486 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(2), CHIA(3), CHIT1(4), CMAS(1), CYB5R1(1), CYB5R3(2), GFPT1(1), GFPT2(1), GNE(4), GNPNAT1(1), HEXA(1), HEXB(2), HK1(3), HK2(3), HK3(3), LHPP(2), MTMR1(2), MTMR2(3), MTMR6(4), NAGK(2), RENBP(2), UAP1(1) 5545996 48 31 48 21 32 1 6 3 6 0 0.894 1.000 1.000 487 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 ACAT1(1), AKR1B10(1), ALDH3A1(2), ALDH9A1(2), BDH2(2), DDHD1(2), EHHADH(1), GAD1(5), HADH(1), HADHA(3), HMGCS1(1), HSD17B10(1), HSD17B4(3), HSD3B7(1), ILVBL(1), L2HGDH(1), OXCT2(1), PDHA2(2), PLA1A(2), PPME1(1), PRDX6(4), RDH13(1) 7845533 39 31 38 19 23 1 6 3 6 0 0.936 1.000 1.000 488 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(2), CALM1(1), CALM2(1), CALML3(1), CALML6(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), CLCA1(2), CLCA2(1), CLCA4(2), CNGA3(1), CNGB1(7), GNAL(1), GUCA1B(1), PDE1C(4), PRKACB(1), PRKG1(1), PRKG2(4), PRKX(1) 5889004 38 31 38 12 20 0 13 5 0 0 0.511 1.000 1.000 489 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(6), IKBKB(4), IL1A(1), IL1B(1), IL1RAP(1), IL6(2), IRAK2(1), IRAK3(3), MAP2K3(2), MAP3K1(3), MAP3K14(2), MAP3K7(3), MAPK14(1), MAPK8(4), MYD88(1), NFKB1(1), NFKBIA(2), RELA(2), TGFB3(1), TOLLIP(1), TRAF6(1) 5728160 43 31 43 16 22 1 8 3 9 0 0.814 1.000 1.000 490 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 27 CALM1(1), CALM2(1), MAP2K1(1), MAP2K3(2), MAP2K4(1), MAP3K1(3), MAPK14(1), MAPK3(3), MAPK8(4), PLCG1(3), PRKCA(1), PTK2B(3), RAC1(1), RAF1(1), SOS1(5), SRC(4), SYT1(2) 5423236 37 31 37 12 20 2 6 6 3 0 0.663 1.000 1.000 491 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 26 AKT3(1), GSK3A(1), IL4R(1), IRS1(3), IRS2(3), JAK1(3), JAK3(3), MAP4K1(3), MAPK3(3), PIK3CD(3), PIK3R1(2), PPP1R13B(3), RAF1(1), SOS1(5), SOS2(4), STAT6(3) 6678531 42 31 42 17 22 0 7 7 6 0 0.876 1.000 1.000 492 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(1), BRAF(1), CREB5(5), DUSP4(1), DUSP6(3), EEF2K(4), EIF4E(1), MAP2K1(1), MAP3K8(2), MAPK3(3), MKNK1(1), MOS(2), NFKB1(1), RAP1A(1), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), SOS1(5), SOS2(4) 5698715 42 31 41 13 25 2 6 3 6 0 0.673 1.000 1.000 493 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(3), DLG4(3), EPHB2(3), F2RL1(3), F2RL3(1), MAPK7(2), MAPK8(4), MYEF2(2), PLD1(3), PLD2(1), PLD3(3), PTK2(3), RAF1(1), RASAL1(1), SRC(4), TEC(4), VAV1(2) 5299718 43 31 43 13 21 1 11 3 7 0 0.527 1.000 1.000 494 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 25 AKT3(1), CISH(1), IL13RA1(1), IL2RG(3), IL4R(1), INPP5D(2), JAK1(3), JAK2(2), JAK3(3), PPP1R13B(3), SERPINA4(1), SOS1(5), SOS2(4), SRC(4), STAT6(3), TYK2(2) 6711570 39 31 39 21 27 0 7 4 1 0 0.976 1.000 1.000 495 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABP1(3), ACADSB(1), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2), AOC3(1), CNDP1(1), DPYD(5), DPYS(5), EHHADH(1), GAD1(5), HADHA(3), SDS(1), UPB1(3) 5614107 36 30 36 13 18 0 9 6 3 0 0.675 1.000 1.000 496 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(1), ACAA2(1), ADH1A(1), ADH1B(2), ADH6(3), ADHFE1(2), AKR1C4(1), AKR1D1(2), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2), BAAT(1), CEL(2), CYP27A1(2), CYP7A1(4), HADHB(2), SRD5A1(1), SRD5A2(1) 4481679 33 30 33 12 16 1 8 4 4 0 0.623 1.000 1.000 497 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 21 ABL1(4), ATM(19), ATR(3), CCNA1(1), CCND1(1), CDC25A(1), CDK2(1), CDK4(2), CDK6(1), CDKN1B(5), CDKN2B(2), E2F1(1), HDAC1(1), SKP2(1), TGFB3(1) 5151374 44 30 44 14 23 2 7 4 8 0 0.772 1.000 1.000 498 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(1), B4GALT1(1), GAA(2), GALE(1), GALK1(1), GALT(1), GANAB(8), GLA(1), GLB1(2), HK1(3), HK2(3), HK3(3), LCT(4), MGAM(6), PFKP(1), PGM1(2) 6303677 40 30 40 20 20 1 8 3 8 0 0.903 1.000 1.000 499 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(2), CALCR(2), CALCRL(2), CD97(3), CRHR2(1), EMR2(1), GHRHR(1), GIPR(1), GLP2R(1), GPR64(2), LPHN1(5), LPHN2(8), LPHN3(5), SCTR(3), VIPR1(1), VIPR2(4) 5135548 42 30 42 24 13 2 14 4 9 0 0.957 1.000 1.000 500 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(1), ALOX15(2), ALOX5(2), CYP1A2(2), CYP2C18(1), CYP2C19(1), CYP2C9(2), CYP2E1(1), CYP3A4(5), CYP3A43(1), CYP3A7(6), HSD3B7(1), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), RDH13(1) 4622175 34 30 34 14 19 0 4 3 8 0 0.698 1.000 1.000 501 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 ARSB(2), FUCA2(2), GALNS(1), GBA(2), GLB1(2), GNS(2), GUSB(1), HEXA(1), HEXB(2), HGSNAT(1), HPSE(3), HPSE2(1), HYAL2(2), IDS(1), LCT(4), MAN2B1(1), MAN2B2(1), MAN2C1(1), MANBA(2), NAGLU(1), NEU2(2), NEU4(1), SPAM1(1) 6653859 37 30 37 11 21 1 7 5 3 0 0.384 1.000 1.000 502 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 23 BLNK(1), FOS(3), LYN(2), MAP2K1(1), MAP3K1(3), MAPK3(3), MAPK8IP3(3), PAPPA(4), RAC1(1), RPS6KA1(1), RPS6KA3(2), SOS1(5), SYK(1), VAV1(2), VAV2(1), VAV3(2) 6102311 35 30 35 14 18 0 10 5 2 0 0.826 1.000 1.000 503 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(1), BIRC3(1), CASP3(1), CASP8(4), CFLAR(1), FADD(1), MAP2K4(1), MAP3K7(3), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(4), NFKBIE(5), NFKBIL2(2), NR2C2(2), RALBP1(1), RIPK1(2), TNFAIP3(2), TNFRSF1B(3), TRADD(1), TRAF2(2) 5270016 41 30 41 14 22 1 9 3 6 0 0.697 1.000 1.000 504 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(1), CHUK(6), IKBKB(4), MAP2K3(2), MAP2K4(1), MAP3K1(3), MAP3K14(2), MAP4K2(4), MAPK14(1), MAPK8(4), NFKB1(1), NFKBIA(2), RELA(2), RIPK1(2), TANK(1), TRADD(1), TRAF2(2) 4665487 39 30 39 13 20 3 6 3 7 0 0.661 1.000 1.000 505 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(4), CSF1R(6), EGF(4), EGFR(3), MET(5), PDGFRA(7), PRKCA(1), SH3KBP1(2), SRC(4) 3757386 36 29 36 12 18 1 11 5 1 0 0.649 1.000 1.000 506 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 APAF1(1), ATM(19), BAX(1), BCL2L1(2), CASP3(1), CASP6(1), CASP9(3), PRKCA(1), PTK2(3), STAT1(4), TLN1(2) 5131074 38 29 38 14 17 1 7 5 8 0 0.876 1.000 1.000 507 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(1), ALDOA(2), FBP1(1), FPGT(5), GMDS(3), GMPPA(1), GMPPB(2), HK1(3), HK2(3), HK3(3), MPI(2), PFKFB1(2), PFKFB3(3), PFKP(1), PMM1(3), PMM2(1) 4624722 36 29 36 16 24 0 4 2 6 0 0.749 1.000 1.000 508 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(2), GPLD1(4), PGAP1(2), PIGB(3), PIGC(1), PIGF(2), PIGG(6), PIGK(3), PIGL(1), PIGM(1), PIGN(1), PIGO(2), PIGS(2), PIGT(1), PIGU(1), PIGV(1), PIGW(1), PIGZ(1) 4592986 35 29 35 13 19 2 7 2 5 0 0.578 1.000 1.000 509 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BNIP1(1), SEC22B(2), SNAP23(1), SNAP25(1), SNAP29(3), STX10(1), STX11(2), STX12(1), STX16(1), STX18(1), STX3(4), STX4(2), STX5(2), STX7(1), STX8(1), TSNARE1(3), USE1(1), VAMP4(1), VAMP5(1), VTI1B(3), YKT6(1) 3229386 34 29 34 12 23 0 6 3 2 0 0.661 1.000 1.000 510 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(4), ADRA1B(1), ADRA1D(2), ADRA2C(1), ADRB1(1), ADRB2(2), CHRM1(1), CHRM3(4), CHRM4(1), DRD3(1), HRH1(4), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(1), HTR1F(1), HTR2B(2), HTR2C(1), HTR4(2), HTR6(1), HTR7(1) 4935543 35 29 35 22 19 3 9 3 1 0 0.855 1.000 1.000 511 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(4), AP2A1(3), AP2M1(1), BIN1(1), CALM1(1), CALM2(1), DNM1(3), EPS15(2), PPP3CA(4), PPP3CB(4), PPP3CC(2), SYNJ1(3), SYNJ2(2), SYT1(2) 4214441 33 29 33 13 19 2 3 5 4 0 0.883 1.000 1.000 512 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(3), CDK7(3), ERCC3(2), GTF2A2(1), GTF2E1(1), GTF2E2(2), GTF2H1(2), MNAT1(1), POLR1A(5), POLR1B(1), POLR2B(1), POLR2C(2), POLR2E(1), POLR2F(1), POLR3B(3), POLR3E(2), POLR3H(1), TAF12(2), TAF13(1), TAF5(1), TAF6(2), TAF9(1) 6764726 39 29 39 14 22 1 5 3 8 0 0.809 1.000 1.000 513 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 31 A1BG(2), AKT3(1), BTK(3), GSK3A(1), INPP5D(2), PPP1R13B(3), PTEN(5), RPS6KA1(1), RPS6KA2(3), RPS6KA3(2), SFN(1), SOS1(5), SOS2(4), TEC(4), YWHAB(2), YWHAE(2), YWHAQ(1), YWHAZ(3) 6423487 45 29 45 15 31 1 6 2 5 0 0.790 1.000 1.000 514 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(3), ACTN1(2), ACTN2(3), ACTN3(2), CAPNS2(1), ITGA1(1), ITGB1(1), ITGB3(2), PTK2(3), RAC1(1), SPTAN1(34), SRC(4), TLN1(2) 5519831 59 29 59 18 38 2 9 1 9 0 0.571 1.000 1.000 515 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 23 ARNT(1), EIF1(1), EIF2B1(1), EIF2B2(3), EIF2B4(2), EIF2B5(2), EIF2S3(2), ELAVL1(2), FLT1(1), FLT4(1), HIF1A(1), KDR(9), NOS3(6), PIK3R1(2), PLCG1(3), PRKCA(1), PTK2(3) 6071899 41 29 41 14 19 1 8 4 9 0 0.659 1.000 1.000 516 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ALDH4A1(1), CAD(7), CPS1(4), EPRS(5), GAD1(5), GCLC(1), GCLM(1), GFPT1(1), GLS(1), GLS2(1), GLUD1(2), GMPS(2), GSS(1), NADSYN1(3), PPAT(2), QARS(3) 6420899 40 28 40 19 22 1 8 4 5 0 0.935 1.000 1.000 517 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 C1GALT1(1), C1GALT1C1(1), GALNT1(1), GALNT11(1), GALNT12(1), GALNT13(1), GALNT2(2), GALNT3(1), GALNT4(1), GALNT5(3), GALNT6(1), GALNT7(1), GALNT8(2), GALNT9(1), GALNTL2(3), GALNTL5(1), GCNT1(1), GCNT4(1), OGT(2), ST3GAL1(1), ST6GALNAC1(1), WBSCR17(3) 6230638 31 28 31 16 19 2 4 4 2 0 0.964 1.000 1.000 518 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 19 CSNK2A1(4), FOS(3), INSR(4), IRS1(3), MAP2K1(1), MAPK3(3), MAPK8(4), PIK3R1(2), RAF1(1), RASA1(4), SLC2A4(1), SOS1(5) 4410762 35 28 35 10 19 1 5 6 4 0 0.512 1.000 1.000 519 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(6), FADD(1), IKBKB(4), IL1A(1), MAP3K1(3), MAP3K14(2), MAP3K7(3), MYD88(1), NFKB1(1), NFKBIA(2), RELA(2), RIPK1(2), TLR4(3), TNFAIP3(2), TNFRSF1B(3), TRADD(1), TRAF6(1) 4699938 38 28 38 11 19 0 9 1 9 0 0.589 1.000 1.000 520 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 17 ABCB1(6), ATM(19), BAX(1), CPB2(3), CSNK1A1(3), GADD45A(1), HIF1A(1), HSPA1A(2), MAPK8(4), NFKBIB(4) 3788757 44 28 44 14 20 2 7 7 8 0 0.800 1.000 1.000 521 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(1), AKR1D1(2), ARSB(2), ARSD(2), CYP11B2(3), HSD17B3(1), HSD17B8(3), HSD3B1(2), HSD3B2(3), SRD5A1(1), SRD5A2(1), STS(2), SULT2A1(1), UGT1A1(3), UGT1A3(3), UGT1A5(1), UGT1A6(1), UGT1A9(2), UGT2B4(2) 5258278 36 27 36 12 20 3 9 3 1 0 0.470 1.000 1.000 522 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 20 FOS(3), JAK2(2), MAP2K1(1), MAP2K4(1), MAP3K1(3), MAPK3(3), MAPK8(4), MYC(1), PIK3R1(2), RAF1(1), SOS1(5), STAT1(4), STAT5B(2) 4920603 32 27 32 14 17 2 5 5 3 0 0.907 1.000 1.000 523 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ACACA(13), ACACB(5), ACAT1(1), ACSS1(1), ALDH3A1(2), ALDH9A1(2), EHHADH(1), HADHA(3), LDHAL6A(1), LDHAL6B(1), MCEE(1), MUT(1), SUCLG1(1) 7678824 33 27 32 14 21 0 3 3 6 0 0.848 1.000 1.000 524 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), BCAT2(1), COASY(2), DPYD(5), DPYS(5), ENPP1(2), ILVBL(1), PANK1(2), PANK2(2), PANK3(2), PANK4(2), PPCDC(1), PPCS(2), UPB1(3), VNN1(1) 3345916 32 27 32 11 16 0 9 6 1 0 0.663 1.000 1.000 525 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 FAU(2), MRPL13(1), MRPS7(1), RPL10A(1), RPL11(2), RPL13(1), RPL22L1(1), RPL23A(1), RPL24(2), RPL26(2), RPL28(1), RPL3(1), RPL31(3), RPL35A(1), RPL37(1), RPL3L(1), RPL6(1), RPL7(1), RPS13(1), RPS18(4), RPS6(3), RPS7(1), RPS9(1) 4382331 34 27 34 21 23 1 9 1 0 0 0.957 1.000 1.000 526 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(5), C5(3), ICAM1(3), IL1A(1), IL6(2), IL8(1), ITGA4(6), ITGAL(2), ITGB1(1), ITGB2(3), SELP(1), VCAM1(1) 4777049 29 27 29 12 17 1 8 2 1 0 0.801 1.000 1.000 527 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 17 CABIN1(3), CALM1(1), CALM2(1), CAPNS2(1), HDAC1(1), HDAC2(1), MEF2D(1), NFATC1(4), NFATC2(6), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKCA(1), SYT1(2) 3762508 32 27 32 11 13 3 5 5 6 0 0.749 1.000 1.000 528 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 19 EIF4A1(1), EIF4A2(3), EIF4E(1), EIF4EBP1(1), EIF4G1(1), EIF4G2(5), EIF4G3(9), MKNK1(1), PDK2(1), PDPK1(1), PIK3R1(2), PPP2CA(1), PTEN(5), RPS6(3), TSC2(2) 4457609 37 27 37 17 16 2 8 3 8 0 0.984 1.000 1.000 529 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(1), ANXA2(1), ANXA4(1), ANXA5(1), ANXA6(3), CYP11A1(1), EDNRA(1), EDNRB(2), PRL(2), PTGDR(3), PTGER2(1), PTGER4(2), PTGFR(2), PTGIR(1), PTGIS(1), PTGS2(2), S100A6(1), TBXAS1(3) 3977901 29 27 29 15 12 0 15 1 1 0 0.923 1.000 1.000 530 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(1), APC(7), AXIN1(3), CTNNB1(4), DLL1(4), NOTCH1(5), PSEN1(5) 4134022 29 27 29 14 14 1 5 2 7 0 0.982 1.000 1.000 531 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(3), COL4A2(5), COL4A3(5), COL4A4(4), COL4A5(2), COL4A6(1), P4HB(3), SLC2A1(3), SLC2A3(4) 4799749 30 27 29 13 13 2 8 3 4 0 0.964 1.000 1.000 532 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(1), BIRC3(1), CASP1(2), CASP3(1), CASP4(2), CASP6(1), CASP8(4), CASP9(3), DFFA(4), LMNA(1), LMNB1(2), LMNB2(1), PRF1(4) 3736459 27 26 27 12 14 0 7 2 4 0 0.923 1.000 1.000 533 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 24 ADCY1(3), CAMK2B(2), CAMK2D(1), CAMK2G(3), GNAS(4), MAPK14(1), MAPK3(3), PIK3R1(2), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PRKCA(1), RAC1(1), RPS6KA1(1), RPS6KA5(3), SOS1(5) 5129526 37 26 37 13 20 1 8 3 5 0 0.720 1.000 1.000 534 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT2(1), AGPAT3(2), AGPS(2), CHPT1(2), ENPP2(1), PAFAH1B1(1), PAFAH1B2(1), PAFAH2(1), PLA2G1B(1), PLA2G2A(1), PLA2G2E(3), PLA2G3(2), PLA2G6(1), PLD1(3), PLD2(1), PPAP2A(5), PPAP2B(1), PPAP2C(1) 4483989 30 26 30 12 18 0 2 3 7 0 0.829 1.000 1.000 535 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(2), DLAT(1), DLD(2), DLST(1), FH(3), IDH3B(2), MDH1(1), OGDH(5), PC(2), PDHA2(2), PDHX(1), PDK2(1), SDHA(3), SDHC(2), SUCLG1(1) 5487307 29 26 29 20 16 2 7 2 2 0 0.996 1.000 1.000 536 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ACACA(13), ACADSB(1), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2), EHHADH(1), HADHA(3), MCEE(1), MUT(1), SDS(1), SUCLG1(1) 6399478 30 26 30 17 21 0 2 2 5 0 0.983 1.000 1.000 537 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 20 F2R(2), F2RL3(1), GNAI1(1), GNB1(5), ITGA1(1), ITGB1(1), MAP2K1(1), MAPK3(3), PLCB1(4), PRKCA(1), PTK2(3), RAF1(1), SRC(4), SYK(1), TBXAS1(3) 4626003 32 26 32 13 16 2 7 7 0 0 0.856 1.000 1.000 538 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(1), ACAA2(1), ACADSB(1), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2), AOX1(2), BCAT1(1), BCKDHA(1), EHHADH(1), HADHA(3), HADHB(2), IVD(1), MCCC1(5), MCCC2(2), MCEE(1), MUT(1), SDS(1) 6960225 32 26 32 16 23 0 5 1 3 0 0.961 1.000 1.000 539 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 23 GHR(2), INSR(4), IRS1(3), JAK2(2), MAP2K1(1), MAPK3(3), PIK3R1(2), PLCG1(3), PRKCA(1), RAF1(1), RPS6KA1(1), SLC2A4(1), SOS1(5), STAT5B(2) 5891256 31 25 31 14 20 0 4 5 2 0 0.882 1.000 1.000 540 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CARM1(2), CTH(2), GGT1(1), LCMT2(1), MAT1A(2), METTL2B(1), PRMT5(3), PRMT6(1), PRMT7(5), PRMT8(4), SCLY(1), WBSCR22(3) 4827465 26 25 25 10 13 3 3 5 2 0 0.702 1.000 1.000 541 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 21 ADCY1(3), BAX(1), BCL2L1(2), CSF2RB(1), IGF1R(5), IL3RA(3), KIT(3), KITLG(2), PIK3R1(2), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1) 3821093 29 24 29 10 7 2 7 4 9 0 0.640 1.000 1.000 542 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 18 CSNK2A1(4), EPOR(1), FOS(3), JAK2(2), MAP2K1(1), MAPK3(3), MAPK8(4), PLCG1(3), RAF1(1), SOS1(5), STAT5B(2) 4071309 29 24 29 10 19 1 2 5 2 0 0.660 1.000 1.000 543 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 25 APC(7), AXIN1(3), CCND1(1), CTNNB1(4), GJA1(1), GNAI1(1), LEF1(2), LY96(1), MYD88(1), NFKB1(1), PDPK1(1), PIK3R1(2), PPP2CA(1), RELA(2), TLR4(3), TOLLIP(1) 5521471 32 24 32 14 12 1 9 1 9 0 0.947 1.000 1.000 544 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP5(3), ACP6(1), ACPP(5), ACPT(3), ALPI(2), ALPL(1), CYP3A4(5), CYP3A43(1), CYP3A7(6), DHRS1(1), DHRS7(2), DHRSX(3), PON1(1), PON2(1) 3476482 35 24 34 17 18 2 7 1 7 0 0.891 1.000 1.000 545 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(8), ABCC2(2), BCHE(3), CES2(2), CYP3A4(5), UGT1A1(3), UGT1A3(3), UGT1A5(1), UGT1A6(1), UGT1A9(2) 4408319 30 24 30 11 17 2 6 3 2 0 0.566 1.000 1.000 546 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(1), CCR1(1), CCR3(3), CCR4(2), CCR5(2), CCR7(3), CD4(1), CXCR3(1), CXCR4(2), IFNG(1), IFNGR2(2), IL12B(2), IL12RB1(2), IL12RB2(1), IL18R1(1), IL4R(1), TGFB3(1) 3867274 27 24 27 11 10 1 9 4 3 0 0.757 1.000 1.000 547 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(1), CALM2(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), CAMK4(1), ESRRA(2), HDAC5(2), MEF2A(1), MEF2C(2), MEF2D(1), PPP3CA(4), PPP3CB(4), PPP3CC(2), SLC2A4(1), SYT1(2) 3904632 30 24 30 12 13 2 5 6 4 0 0.791 1.000 1.000 548 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(1), ADSL(1), ADSS(2), ASL(3), ASPA(2), CAD(7), CRAT(5), DARS(2), GAD1(5), NARS(1), PC(2) 5044734 31 23 31 14 17 0 6 5 3 0 0.838 1.000 1.000 549 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(4), CHAT(2), COMT(2), DBH(3), DDC(3), GAD1(5), HDC(2), MAOA(1), PAH(3), SLC18A3(1) 2779711 26 23 26 15 11 1 9 1 4 0 0.956 1.000 1.000 550 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(3), CD2(1), CD33(2), CD5(1), CD7(2), IFNG(1), IL12B(2), TLR2(2), TLR4(3), TLR7(6), TLR9(2) 3589504 25 23 25 10 12 1 6 2 4 0 0.639 1.000 1.000 551 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(3), GCLC(1), GCLM(1), GGT1(1), GPX3(2), GPX6(2), GSR(2), GSS(1), GSTA1(1), GSTA2(1), GSTA4(1), GSTA5(2), GSTM2(1), GSTM3(1), GSTM5(2), GSTP1(2), GSTZ1(1), IDH1(3), OPLAH(1) 4255262 29 23 29 14 13 2 7 2 5 0 0.834 1.000 1.000 552 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP5(3), ACP6(1), ACPP(5), ACPT(3), ENPP1(2), FLAD1(1), LHPP(2), MTMR1(2), MTMR2(3), MTMR6(4), RFK(1), TYR(3) 2905957 30 23 29 11 18 2 7 1 2 0 0.824 1.000 1.000 553 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 18 EIF2B5(2), EIF2S3(2), EIF4E(1), EIF4EBP1(1), IGF1R(5), INPPL1(2), PDK2(1), PDPK1(1), PIK3R1(2), PPP2CA(1), PTEN(5), RPS6(3) 3386763 26 23 26 10 10 0 9 2 5 0 0.821 1.000 1.000 554 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), COASY(2), DPYD(5), DPYS(5), ENPP1(2), PANK1(2), PANK2(2), PANK3(2), PANK4(2), PPCS(2), UPB1(3) 2693978 28 23 28 10 14 0 8 5 1 0 0.743 1.000 1.000 555 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 23 ACTA1(3), CAPNS2(1), CXCR3(1), EGF(4), EGFR(3), ITGA1(1), ITGB1(1), MAPK3(3), MYL2(2), MYLK(5), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2A(3), PRKAR2B(1), PTK2(3), TLN1(2) 6239576 36 22 36 15 20 2 9 3 2 0 0.831 1.000 1.000 556 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 10 ATM(19), CDC25A(1), CDK2(1), CDK4(2), CHEK1(1), MYT1(3), WEE1(2) 2898185 29 22 29 12 14 2 4 4 5 0 0.944 1.000 1.000 557 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(2), AGT(1), AGTR2(1), COL4A1(3), COL4A2(5), COL4A3(5), COL4A4(4), COL4A5(2), COL4A6(1), REN(2) 4830988 26 21 25 11 9 0 10 2 5 0 0.965 1.000 1.000 558 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 15 ADAM12(1), AGT(1), AGTR2(1), EDNRA(1), EDNRB(2), EGF(4), EGFR(3), FOS(3), MYC(1), NFKB1(1), PLCG1(3), PRKCA(1), RELA(2) 3885757 24 21 24 11 12 1 8 1 2 0 0.844 1.000 1.000 559 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(1), ACO2(2), DLD(2), DLST(1), FH(3), IDH1(3), IDH3B(2), MDH1(1), PC(2), PCK1(3), SDHA(3), SUCLG1(1) 3984886 24 21 24 13 12 0 7 2 3 0 0.949 1.000 1.000 560 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 13 APAF1(1), ATM(19), BAX(1), CCND1(1), CDK2(1), CDK4(2), E2F1(1), GADD45A(1), PCNA(1) 2942050 28 21 28 11 14 1 5 3 5 0 0.916 1.000 1.000 561 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AP2A1(3), AP2M1(1), BTK(3), EEA1(6), GRASP(2), GSK3A(1), LYN(2), PDPK1(1), PFKP(1), PLCG1(3), PRKCZ(2), RAB5A(1), RAC1(1), VAV2(1) 4869144 28 21 28 11 17 0 6 4 1 0 0.738 1.000 1.000 562 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(19), CDC25A(1), CHEK1(1), MYT1(3), WEE1(2) 2657515 26 20 26 11 11 2 4 4 5 0 0.953 1.000 1.000 563 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(2), FBP1(1), GPI(3), H6PD(5), PFKP(1), PGD(1), PGM1(2), RBKS(1), RPIA(2), TKTL1(3), TKTL2(1) 4707229 22 20 22 12 9 0 8 1 4 0 0.873 1.000 1.000 564 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(4), EXT2(3), EXTL1(1), EXTL2(2), EXTL3(2), GLCE(1), HS2ST1(1), HS3ST5(1), HS6ST1(1), NDST2(1), NDST3(2), NDST4(2) 3985201 21 20 21 12 12 0 3 3 3 0 0.917 1.000 1.000 565 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(4), IL22RA1(1), JAK1(3), JAK2(2), JAK3(3), STAT1(4), STAT5B(2), TYK2(2) 3562698 21 20 21 12 11 0 2 3 5 0 0.940 1.000 1.000 566 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 ICAM1(3), ITGA4(6), ITGAL(2), ITGAM(3), ITGB1(1), ITGB2(3), SELE(1), SELP(1) 3076178 20 20 20 11 13 0 5 2 0 0 0.941 1.000 1.000 567 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(1), DARS(2), EPRS(5), GARS(1), KARS(3), LARS(1), LARS2(1), NARS(1), QARS(3), RARS(1), SARS(2), YARS(3) 6194728 24 19 24 14 14 1 5 1 3 0 0.980 1.000 1.000 568 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(1), CYB5R3(2), GFPT1(1), GNE(4), HEXA(1), HEXB(2), HK1(3), HK2(3), HK3(3), RENBP(2), UAP1(1) 3278556 23 18 23 16 14 1 4 0 4 0 0.992 1.000 1.000 569 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH3A1(2), ALDH9A1(2), EHHADH(1), GAD1(5), HADHA(3), L2HGDH(1), PDHA2(2), SDS(1) 4989515 21 18 21 15 12 0 4 1 4 0 0.994 1.000 1.000 570 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(3), GCLC(1), GCLM(1), GGT1(1), GPX3(2), GSS(1), GSTA1(1), GSTA2(1), GSTA4(1), GSTM2(1), GSTM3(1), GSTM5(2), GSTP1(2), GSTZ1(1), IDH1(3), PGD(1) 3491974 23 18 23 12 13 1 4 0 5 0 0.846 1.000 1.000 571 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT2(3), B3GAT3(1), B4GALT7(1), CHPF(2), CHST11(1), CHST12(1), CHST14(1), CHST7(1), CHSY1(2), DSE(2), UST(1), XYLT1(3), XYLT2(2) 2684031 21 18 21 10 12 1 3 3 2 0 0.758 1.000 1.000 572 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(2), CD3E(1), CXCR3(1), ETV5(1), IFNG(1), IL12B(2), IL12RB1(2), IL12RB2(1), IL18R1(1), JAK2(2), MAPK14(1), MAPK8(4), STAT4(1), TYK2(2) 3598829 22 18 22 20 11 0 8 2 1 0 1.000 1.000 1.000 573 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 12 ABL1(4), E2F1(1), MYC(1), PIK3R1(2), POLR1A(5), POLR1B(1), POLR1C(1), POLR1D(2), RAC1(1), TBX2(3) 2895053 21 17 21 10 12 1 4 2 2 0 0.900 1.000 1.000 574 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 14 MAP2K1(1), MAP2K3(2), MAP3K1(3), MAPK14(1), MAPK3(3), NFKB1(1), PIK3R1(2), RELA(2), SP1(3) 2993760 18 17 18 10 6 1 4 3 4 0 0.963 1.000 1.000 575 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(3), EPHB1(4), FYN(1), ITGA1(1), ITGB1(1), L1CAM(2), LYN(2), RAP1B(2), SELP(1) 3053500 17 16 17 10 11 1 4 1 0 0 0.957 1.000 1.000 576 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 ICAM1(3), ITGA4(6), ITGAL(2), ITGB1(1), ITGB2(3), SELE(1) 2335119 16 16 16 8 10 0 4 2 0 0 0.892 1.000 1.000 577 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(2), CD2(1), CD3E(1), CD4(1), CXCR3(1), IFNG(1), IL12B(2), IL12RB1(2), IL12RB2(1), JAK2(2), STAT4(1), TYK2(2) 2835218 17 16 17 14 8 0 7 1 1 0 0.996 1.000 1.000 578 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 13 EGFR(3), IGF1R(5), MYC(1), PPP2CA(1), PRKCA(1), TEP1(4), TERT(1), TNKS(2), XRCC5(1) 4954640 19 16 19 12 6 1 6 4 2 0 0.970 1.000 1.000 579 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(1), CNR2(3), DNMT1(4), MTNR1A(1), PTAFR(1), PTGDR(3), PTGER2(1), PTGER4(2), PTGFR(2), PTGIR(1) 2160318 19 15 19 13 7 1 9 1 1 0 0.912 1.000 1.000 580 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(4), ACO1(1), ACO2(2), ACSS1(1), FH(3), IDH1(3), MDH1(1) 2571940 15 14 15 12 8 0 2 2 3 0 0.987 1.000 1.000 581 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(2), FH(3), MDH1(1), OGDH(5), SDHA(3) 1818782 14 14 14 10 6 1 4 2 1 0 0.979 1.000 1.000 582 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP5(3), ACPP(5), ACPT(3), ENPP1(2), FLAD1(1), RFK(1), TYR(3) 1873311 18 14 17 10 10 1 6 0 1 0 0.964 1.000 1.000 583 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(1), CALM2(1), CAMK2B(2), CAMK2D(1), CAMK2G(3), CAMK4(1), CAMKK2(3), SYT1(2) 2229297 14 13 14 10 7 0 2 1 4 0 0.982 1.000 1.000 584 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 HK1(3), HK2(3), HK3(3), IMPA1(1), IMPA2(1), ISYNA1(1), PGM1(2) 2263142 14 13 14 11 9 0 2 1 2 0 0.987 1.000 1.000 585 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), ASRGL1(1), CA12(1), CA4(1), CPS1(4), CTH(2), GLS(1), GLS2(1), GLUD1(2), GLUD2(3), HAL(3) 4102451 20 13 20 10 9 1 7 0 3 0 0.934 1.000 1.000 586 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(2), CD38(1), ENPP1(2), NADSYN1(3), NNMT(1), NNT(1), NT5E(3), QPRT(2) 2810480 15 13 15 6 8 2 4 1 0 0 0.792 1.000 1.000 587 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(3), JAK2(2), JAK3(3), MAPK3(3), TYK2(2) 2273441 13 13 13 11 7 0 2 3 1 0 0.990 1.000 1.000 588 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(3), APAF1(1), CASP3(1), CASP9(3), DAXX(1), HSPB2(2), IL1A(1), MAPKAPK2(1) 2194483 13 12 13 10 6 2 3 0 2 0 0.988 1.000 1.000 589 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 ICAM1(3), ITGAL(2), ITGAM(3), ITGB2(3), SELE(1) 2005411 12 12 12 7 7 0 4 1 0 0 0.889 1.000 1.000 590 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ITPKA(2), PDE1A(2), PLCB1(4), PLCB2(1), PRL(2), TRH(1) 2143051 12 12 12 5 5 0 5 2 0 0 0.779 1.000 1.000 591 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 HK1(3), HK2(3), HK3(3), IMPA1(1), PGM1(2) 1982881 12 12 12 10 8 0 2 0 2 0 0.990 1.000 1.000 592 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(4), MDH1(1), ME1(2), PC(2), SLC25A1(1), SLC25A11(1) 1792284 11 11 11 11 8 0 2 0 1 0 0.991 1.000 1.000 593 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(4), CHAT(2), CHKA(1), PCYT1A(1), PDHA2(2), SLC18A3(1) 1346557 11 10 11 10 3 1 7 0 0 0 0.988 1.000 1.000 594 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS2(3), CTH(2), LDHAL6A(1), LDHAL6B(1), SDS(1), SULT1C2(1), SULT1C4(2) 2426832 11 10 11 5 3 1 6 1 0 0 0.846 1.000 1.000 595 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(1), CDC25A(1), CSK(4), PRKCA(1), PTPRA(1), SRC(4) 1788561 12 10 12 8 6 2 3 1 0 0 0.957 1.000 1.000 596 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ENO1(2), GPI(3), HK1(3), PGAM1(1), PKLR(1) 1800386 10 9 10 10 6 0 2 1 1 0 0.990 1.000 1.000 597 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(2), CHST11(1), CHST12(1), SULT1A1(1), SULT2A1(1), SULT2B1(1), SUOX(1) 1787499 8 8 8 11 5 0 1 2 0 0 0.999 1.000 1.000 598 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(1), GPD2(1), SDHA(3), SDHC(2) 1280620 7 7 7 6 4 1 2 0 0 0 0.985 1.000 1.000 599 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(4), APOBEC1(2), APOBEC2(1), APOBEC4(1) 1417496 8 7 8 4 6 0 1 1 0 0 0.836 1.000 1.000 600 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 HDAC9(2), MEF2A(1), MEF2C(2), MEF2D(1), MYOD1(1) 1461085 7 7 7 6 2 1 3 1 0 0 0.979 1.000 1.000 601 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMPR1A(1), BMPR1B(2), BMPR2(5) 1206668 8 7 8 5 8 0 0 0 0 0 0.948 1.000 1.000 602 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASS(3), KARS(3) 908261 6 6 6 5 4 0 1 1 0 0 0.987 1.000 1.000 603 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(1), EPHX2(2), HSD3B7(1), RDH13(1) 929465 5 5 5 5 4 1 0 0 0 0 0.933 1.000 1.000 604 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), LARS(1), LARS2(1), PDHA2(2) 1933941 5 5 5 3 3 0 2 0 0 0 0.933 1.000 1.000 605 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(2), ALDH1A2(1), BCMO1(1) 753607 4 4 4 4 2 0 1 1 0 0 0.969 1.000 1.000 606 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(1), PLCD1(1), PRKCA(1), TGM2(1) 964152 4 4 4 3 2 0 0 2 0 0 0.916 1.000 1.000 607 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(2), SULT2A1(1), SUOX(1) 1180420 4 4 4 8 2 0 1 1 0 0 1.000 1.000 1.000 608 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(2), CD3E(1), CD4(1) 620923 4 3 4 5 2 0 1 1 0 0 0.986 1.000 1.000 609 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CTH(2) 1323441 2 2 2 3 0 1 1 0 0 0 0.986 1.000 1.000 610 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 PGLYRP2(1) 351636 1 1 1 2 0 1 0 0 0 0 0.983 1.000 1.000 611 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 GSTZ1(1) 430986 1 1 1 3 1 0 0 0 0 0 0.994 1.000 1.000 612 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 318050 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 613 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 509080 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 614 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 140554 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 615 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 98540 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 616 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 295672 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000