Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.055 0.237 -9999.0 0.0 -0.632 41.0 41.0 IHH -0.061 0.186 -9999.0 0.0 -0.518 48.0 48.0 SHH Np/Cholesterol/GAS1 -0.173 0.2 -9999.0 0.0 -0.349 189.0 189.0 LRPAP1 0.014 0.028 -9999.0 0.0 -0.507 1.0 1.0 dorsoventral neural tube patterning 0.172 0.198 0.346 189.0 -9999.0 0.0 189.0 SMO/beta Arrestin2 -0.046 0.162 -9999.0 0.0 -0.497 22.0 22.0 SMO -0.057 0.17 -9999.0 0.0 -0.493 29.0 29.0 AKT1 -0.002 0.08 -9999.0 0.0 -0.286 3.0 3.0 ARRB2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.037 0.169 -9999.0 0.0 -0.576 32.0 32.0 ADRBK1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.056 0.167 -9999.0 0.0 -0.485 29.0 29.0 STIL -0.15 0.214 -9999.0 0.0 -0.477 73.0 73.0 DHH N/PTCH2 -0.017 0.128 -9999.0 0.0 -0.427 31.0 31.0 DHH N/PTCH1 -0.036 0.16 -9999.0 0.0 -0.495 22.0 22.0 PIK3CA 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.016 0.129 -9999.0 0.0 -0.576 18.0 18.0 PTHLH -0.105 0.361 -9999.0 0.0 -1.036 41.0 41.0 determination of left/right symmetry -0.056 0.167 -9999.0 0.0 -0.485 29.0 29.0 PIK3R1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.103 0.355 -9999.0 0.0 -1.019 41.0 41.0 IHH N/Hhip -0.143 0.233 -9999.0 0.0 -0.482 104.0 104.0 DHH N/Hhip -0.113 0.208 -9999.0 0.0 -0.427 106.0 106.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.056 0.167 -9999.0 0.0 -0.485 29.0 29.0 pancreas development -0.138 0.257 -9999.0 0.0 -0.574 92.0 92.0 HHAT 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.023 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.122 0.25 -9999.0 0.0 -0.575 83.0 83.0 somite specification -0.056 0.167 -9999.0 0.0 -0.485 29.0 29.0 SHH Np/Cholesterol/PTCH1 -0.12 0.192 -9999.0 0.0 -0.448 53.0 53.0 SHH Np/Cholesterol/PTCH2 -0.109 0.174 -9999.0 0.0 -0.324 137.0 137.0 SHH Np/Cholesterol/Megalin -0.156 0.202 -9999.0 0.0 -0.353 169.0 169.0 SHH -0.135 0.209 -9999.0 0.0 -0.414 128.0 128.0 catabolic process -0.03 0.155 -9999.0 0.0 -0.536 15.0 15.0 SMO/Vitamin D3 -0.114 0.199 -9999.0 0.0 -0.471 47.0 47.0 SHH Np/Cholesterol/Hhip -0.183 0.22 -9999.0 0.0 -0.38 182.0 182.0 LRP2 -0.093 0.21 -9999.0 0.0 -0.507 73.0 73.0 receptor-mediated endocytosis -0.151 0.206 -9999.0 0.0 -0.48 63.0 63.0 SHH Np/Cholesterol/BOC -0.126 0.184 -9999.0 0.0 -0.334 150.0 150.0 SHH Np/Cholesterol/CDO -0.143 0.186 -9999.0 0.0 -0.334 167.0 167.0 mesenchymal cell differentiation 0.181 0.218 0.377 182.0 -9999.0 0.0 182.0 mol:Vitamin D3 -0.118 0.193 -9999.0 0.0 -0.448 53.0 53.0 IHH N/PTCH2 -0.04 0.141 -9999.0 0.0 -0.334 62.0 62.0 CDON -0.067 0.205 -9999.0 0.0 -0.576 50.0 50.0 IHH N/PTCH1 -0.03 0.156 -9999.0 0.0 -0.543 15.0 15.0 Megalin/LRPAP1 -0.057 0.153 -9999.0 0.0 -0.355 74.0 74.0 PTCH2 -0.008 0.115 -9999.0 0.0 -0.576 14.0 14.0 SHH Np/Cholesterol -0.113 0.156 -9999.0 0.0 -0.321 128.0 128.0 PTCH1 -0.03 0.155 -9999.0 0.0 -0.538 15.0 15.0 HHIP -0.139 0.257 -9999.0 0.0 -0.574 92.0 92.0