Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.026 0.053 -9999.0 0.0 -0.245 13.0 13.0 epithelial cell differentiation -0.01 0.053 -9999.0 0.0 -0.283 13.0 13.0 CYFIP2 -0.001 0.098 -9999.0 0.0 -0.576 10.0 10.0 ENAH 0.06 0.056 -9999.0 0.0 -0.329 1.0 1.0 EGFR -0.008 0.112 -9999.0 0.0 -0.539 15.0 15.0 EPHA2 0.011 0.054 -9999.0 0.0 -0.576 3.0 3.0 MYO6 0.032 0.058 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.021 0.062 -9999.0 0.0 -0.344 10.0 10.0 AQP5 -0.013 0.047 -9999.0 0.0 -0.349 1.0 1.0 CTNND1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.032 0.057 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.018 0.086 -9999.0 0.0 -0.505 2.0 2.0 EGF -0.018 0.125 -9999.0 0.0 -0.507 22.0 22.0 NCKAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.093 0.196 -9999.0 0.0 -0.494 66.0 66.0 cortical microtubule organization -0.01 0.053 -9999.0 0.0 -0.283 13.0 13.0 GO:0000145 0.031 0.054 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.025 0.061 -9999.0 0.0 -0.286 13.0 13.0 MLLT4 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.013 0.052 -9999.0 0.0 -0.462 1.0 1.0 ARF6 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.03 0.055 -9999.0 0.0 -0.304 3.0 3.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.045 0.056 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.032 0.06 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP -0.008 0.043 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.006 0.111 -9999.0 0.0 -0.576 13.0 13.0 EGFR/EGFR/EGF/EGF -0.032 0.085 -9999.0 0.0 -0.506 3.0 3.0 RhoA/GDP -0.01 0.049 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.038 0.058 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.011 0.054 -9999.0 0.0 -0.575 3.0 3.0 GIT1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.011 0.054 -9999.0 0.0 -0.576 3.0 3.0 IGF1 -0.248 0.294 -9999.0 0.0 -0.576 159.0 159.0 DIAPH1 -0.015 0.097 -9999.0 0.0 -0.584 10.0 10.0 Wnt receptor signaling pathway 0.01 0.053 0.283 13.0 -9999.0 0.0 13.0 RHOA 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.014 0.053 -9999.0 0.0 -0.462 1.0 1.0 CTNNA1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.038 0.059 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.002 0.082 -9999.0 0.0 -0.507 9.0 9.0 LPP 0.04 0.055 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.016 0.063 -9999.0 0.0 -0.535 1.0 1.0 SEC6/SEC8 -0.008 0.041 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.018 0.087 -9999.0 0.0 -0.515 2.0 2.0 HGF/MET -0.069 0.114 -9999.0 0.0 -0.492 2.0 2.0 HGF -0.124 0.249 -9999.0 0.0 -0.57 85.0 85.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.026 0.053 -9999.0 0.0 -0.246 13.0 13.0 actin cable formation 0.077 0.054 -9999.0 0.0 -0.261 1.0 1.0 KIAA1543 0.031 0.096 -9999.0 0.0 -0.531 8.0 8.0 KIFC3 0.032 0.058 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.032 0.058 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.023 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.01 0.053 -9999.0 0.0 -0.283 13.0 13.0 EXOC4 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.032 0.058 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.032 0.058 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.055 0.063 -9999.0 0.0 -0.397 1.0 1.0 adherens junction assembly 0.049 0.095 -9999.0 0.0 -0.506 8.0 8.0 IGF-1R heterotetramer/IGF1 -0.123 0.133 -9999.0 0.0 -0.536 5.0 5.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.023 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.014 0.028 -9999.0 0.0 -0.507 1.0 1.0 PLEKHA7 0.032 0.064 -9999.0 0.0 -0.559 1.0 1.0 mol:GTP 0.029 0.055 -9999.0 0.0 -0.302 3.0 3.0 establishment of epithelial cell apical/basal polarity 0.061 0.052 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.026 0.053 -9999.0 0.0 -0.245 13.0 13.0 regulation of cell-cell adhesion 0.038 0.058 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.026 0.053 -9999.0 0.0 -0.246 13.0 13.0