Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.053 0.298 -9999.0 0.0 -0.811 131.0 131.0 IHH -0.014 0.082 -9999.0 0.0 -0.418 9.0 9.0 SHH Np/Cholesterol/GAS1 -0.032 0.117 -9999.0 0.0 -0.489 65.0 65.0 LRPAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.031 0.116 0.486 65.0 -9999.0 0.0 65.0 SMO/beta Arrestin2 -0.075 0.229 -9999.0 0.0 -0.839 81.0 81.0 SMO -0.036 0.262 -9999.0 0.0 -0.849 90.0 90.0 AKT1 0.007 0.115 -9999.0 0.0 -0.441 22.0 22.0 ARRB2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.059 0.208 -9999.0 0.0 -0.79 82.0 82.0 ADRBK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.034 0.254 -9999.0 0.0 -0.825 90.0 90.0 STIL -0.038 0.209 -9999.0 0.0 -0.684 88.0 88.0 DHH N/PTCH2 -0.063 0.193 -9999.0 0.0 -0.635 107.0 107.0 DHH N/PTCH1 -0.089 0.24 -9999.0 0.0 -0.739 115.0 115.0 PIK3CA -0.0 0.009 -9999.0 0.0 -0.293 1.0 1.0 DHH -0.022 0.13 -9999.0 0.0 -0.759 32.0 32.0 PTHLH -0.081 0.379 -9999.0 0.0 -1.057 131.0 131.0 determination of left/right symmetry -0.034 0.254 -9999.0 0.0 -0.825 90.0 90.0 PIK3R1 -0.009 0.086 -9999.0 0.0 -0.79 13.0 13.0 skeletal system development -0.079 0.37 -9999.0 0.0 -1.034 131.0 131.0 IHH N/Hhip -0.015 0.049 -9999.0 0.0 -0.411 6.0 6.0 DHH N/Hhip -0.019 0.104 -9999.0 0.0 -0.612 32.0 32.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.034 0.254 -9999.0 0.0 -0.825 90.0 90.0 pancreas development -0.004 0.042 -9999.0 0.0 -0.392 10.0 10.0 HHAT -0.001 0.024 -9999.0 0.0 -0.79 1.0 1.0 PI3K -0.007 0.066 -9999.0 0.0 -0.602 13.0 13.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.046 0.186 -9999.0 0.0 -0.79 64.0 64.0 somite specification -0.034 0.254 -9999.0 0.0 -0.825 90.0 90.0 SHH Np/Cholesterol/PTCH1 -0.071 0.204 -9999.0 0.0 -0.696 94.0 94.0 SHH Np/Cholesterol/PTCH2 -0.04 0.131 -9999.0 0.0 -0.486 85.0 85.0 SHH Np/Cholesterol/Megalin -0.135 0.214 -9999.0 0.0 -0.486 291.0 291.0 SHH 0.01 0.036 -9999.0 0.0 -0.611 1.0 1.0 catabolic process -0.047 0.256 -9999.0 0.0 -0.818 96.0 96.0 SMO/Vitamin D3 -0.074 0.223 -9999.0 0.0 -0.789 86.0 86.0 SHH Np/Cholesterol/Hhip -0.005 0.036 -9999.0 0.0 -0.366 7.0 7.0 LRP2 -0.217 0.347 -9999.0 0.0 -0.747 317.0 317.0 receptor-mediated endocytosis -0.149 0.25 -9999.0 0.0 -0.811 100.0 100.0 SHH Np/Cholesterol/BOC -0.04 0.13 -9999.0 0.0 -0.488 83.0 83.0 SHH Np/Cholesterol/CDO -0.01 0.061 -9999.0 0.0 -0.482 16.0 16.0 mesenchymal cell differentiation 0.005 0.035 0.364 7.0 -9999.0 0.0 7.0 mol:Vitamin D3 -0.029 0.22 -9999.0 0.0 -0.699 94.0 94.0 IHH N/PTCH2 -0.063 0.18 -9999.0 0.0 -0.657 88.0 88.0 CDON -0.011 0.092 -9999.0 0.0 -0.79 15.0 15.0 IHH N/PTCH1 -0.044 0.26 -9999.0 0.0 -0.825 96.0 96.0 Megalin/LRPAP1 -0.165 0.265 -9999.0 0.0 -0.602 290.0 290.0 PTCH2 -0.061 0.21 -9999.0 0.0 -0.79 84.0 84.0 SHH Np/Cholesterol -0.003 0.025 -9999.0 0.0 -0.494 1.0 1.0 PTCH1 -0.047 0.258 -9999.0 0.0 -0.823 96.0 96.0 HHIP -0.004 0.042 -9999.0 0.0 -0.392 10.0 10.0