Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.009 0.054 -9999.0 0.0 -0.323 31.0 31.0 epithelial cell differentiation -0.012 0.072 -9999.0 0.0 -0.44 30.0 30.0 CYFIP2 -0.01 0.066 -9999.0 0.0 -0.357 31.0 31.0 ENAH 0.057 0.058 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.297 0.382 -9999.0 0.0 -0.784 414.0 414.0 EPHA2 -0.004 0.058 -9999.0 0.0 -0.79 6.0 6.0 MYO6 -0.012 0.069 -9999.0 0.0 -0.417 31.0 31.0 CTNNB1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.005 0.038 -9999.0 0.0 -0.518 4.0 4.0 AQP5 -0.231 0.289 -9999.0 0.0 -0.584 426.0 426.0 CTNND1 -0.0 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.011 0.067 -9999.0 0.0 -0.41 30.0 30.0 regulation of calcium-dependent cell-cell adhesion -0.033 0.112 -9999.0 0.0 -0.415 86.0 86.0 EGF -0.155 0.314 -9999.0 0.0 -0.785 216.0 216.0 NCKAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.038 0.141 -9999.0 0.0 -0.589 56.0 56.0 cortical microtubule organization -0.012 0.072 -9999.0 0.0 -0.44 30.0 30.0 GO:0000145 0.026 0.07 -9999.0 0.0 -0.391 30.0 30.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.012 0.073 -9999.0 0.0 -0.446 30.0 30.0 MLLT4 -0.005 0.059 -9999.0 0.0 -0.719 7.0 7.0 ARF6/GDP -0.012 0.061 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.003 0.036 -9999.0 0.0 -0.47 6.0 6.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.036 0.074 -9999.0 0.0 -0.382 30.0 30.0 PVRL2 -0.001 0.015 -9999.0 0.0 -0.293 3.0 3.0 ZYX -0.012 0.068 -9999.0 0.0 -0.417 30.0 30.0 ARF6/GTP -0.003 0.033 -9999.0 0.0 -0.431 6.0 6.0 CDH1 -0.022 0.129 -9999.0 0.0 -0.79 30.0 30.0 EGFR/EGFR/EGF/EGF -0.243 0.259 -9999.0 0.0 -0.467 566.0 566.0 RhoA/GDP -0.011 0.067 -9999.0 0.0 -0.412 30.0 30.0 actin cytoskeleton organization 0.032 0.073 -9999.0 0.0 -0.392 31.0 31.0 IGF-1R heterotetramer -0.02 0.115 -9999.0 0.0 -0.788 22.0 22.0 GIT1 -0.001 0.02 -9999.0 0.0 -0.293 5.0 5.0 IGF1R -0.02 0.115 -9999.0 0.0 -0.79 22.0 22.0 IGF1 -0.178 0.33 -9999.0 0.0 -0.79 246.0 246.0 DIAPH1 -0.002 0.043 -9999.0 0.0 -0.693 4.0 4.0 Wnt receptor signaling pathway 0.012 0.072 0.44 30.0 -9999.0 0.0 30.0 RHOA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.012 0.061 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.033 0.074 -9999.0 0.0 -0.403 30.0 30.0 EFNA1 -0.0 0.009 -9999.0 0.0 -0.293 1.0 1.0 LPP 0.03 0.081 -9999.0 0.0 -0.393 38.0 38.0 Ephrin A1/EPHA2 -0.013 0.071 -9999.0 0.0 -0.398 36.0 36.0 SEC6/SEC8 -0.012 0.067 -9999.0 0.0 -0.746 1.0 1.0 MGAT3 -0.034 0.114 -9999.0 0.0 -0.423 86.0 86.0 HGF/MET -0.108 0.201 -9999.0 0.0 -0.446 264.0 264.0 HGF -0.053 0.198 -9999.0 0.0 -0.776 75.0 75.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.009 0.054 -9999.0 0.0 -0.326 31.0 31.0 actin cable formation 0.072 0.057 -9999.0 0.0 -0.322 1.0 1.0 KIAA1543 0.031 0.089 -9999.0 0.0 -0.455 31.0 31.0 KIFC3 -0.012 0.07 -9999.0 0.0 -0.417 32.0 32.0 NCK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.012 0.069 -9999.0 0.0 -0.417 31.0 31.0 NCK1/GIT1 -0.001 0.013 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.012 0.072 -9999.0 0.0 -0.44 30.0 30.0 EXOC4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.012 0.068 -9999.0 0.0 -0.417 30.0 30.0 PIP5K1C -0.012 0.068 -9999.0 0.0 -0.417 30.0 30.0 LIMA1 -0.001 0.024 -9999.0 0.0 -0.79 1.0 1.0 ABI1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.01 0.054 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.047 0.085 -9999.0 0.0 -0.663 6.0 6.0 IGF-1R heterotetramer/IGF1 -0.111 0.195 -9999.0 0.0 -0.43 280.0 280.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.004 0.046 -9999.0 0.0 -0.602 6.0 6.0 MET -0.136 0.298 -9999.0 0.0 -0.79 188.0 188.0 PLEKHA7 -0.013 0.078 -9999.0 0.0 -0.46 30.0 30.0 mol:GTP -0.003 0.036 -9999.0 0.0 -0.466 6.0 6.0 establishment of epithelial cell apical/basal polarity -0.012 0.063 -9999.0 0.0 -0.702 1.0 1.0 cortical actin cytoskeleton stabilization -0.009 0.054 -9999.0 0.0 -0.323 31.0 31.0 regulation of cell-cell adhesion 0.032 0.073 -9999.0 0.0 -0.392 31.0 31.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.009 0.054 -9999.0 0.0 -0.326 31.0 31.0