E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.036 0.148 -9999.0 0.0 -0.426 44.0 44.0 KLHL20 0.042 0.114 0.304 41.0 -0.258 14.0 55.0 CYFIP2 0.05 0.047 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.003 0.117 0.337 4.0 -0.3 26.0 30.0 ENAH -0.03 0.143 -9999.0 0.0 -0.427 38.0 38.0 AP1M1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.03 0.052 -9999.0 0.0 -0.543 4.0 4.0 CDC42/GTP 0.009 0.075 -9999.0 0.0 -0.29 2.0 2.0 ABI1/Sra1/Nap1 -0.015 0.04 -9999.0 0.0 -0.174 13.0 13.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.05 0.095 -9999.0 0.0 -0.31 26.0 26.0 RAPGEF1 -0.028 0.142 0.311 2.0 -0.397 40.0 42.0 CTNND1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.03 0.164 -9999.0 0.0 -0.438 51.0 51.0 CRK -0.026 0.145 0.346 1.0 -0.412 46.0 47.0 E-cadherin/gamma catenin/alpha catenin 0.037 0.089 -9999.0 0.0 -0.343 21.0 21.0 alphaE/beta7 Integrin 0.046 0.016 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.055 0.042 -9999.0 0.0 -0.309 3.0 3.0 DLG1 -0.038 0.158 -9999.0 0.0 -0.427 51.0 51.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.021 0.061 -9999.0 0.0 -0.197 14.0 14.0 MLLT4 0.029 0.046 -9999.0 0.0 -0.542 3.0 3.0 ARF6/GTP/NME1/Tiam1 0.058 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.022 0.08 -9999.0 0.0 -0.257 13.0 13.0 ARF6 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.021 0.095 -9999.0 0.0 -0.321 32.0 32.0 TIAM1 0.035 0.012 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.047 0.089 -9999.0 0.0 -0.292 26.0 26.0 AKT1 -0.007 0.056 -9999.0 0.0 -0.184 2.0 2.0 PIK3R1 -0.02 0.166 -9999.0 0.0 -0.543 47.0 47.0 CDH1 0.007 0.118 0.18 6.0 -0.542 22.0 28.0 RhoA/GDP 0.002 0.116 0.326 4.0 -0.302 25.0 29.0 actin cytoskeleton organization 0.037 0.093 0.253 44.0 -0.19 12.0 56.0 CDC42/GDP 0.001 0.116 0.326 4.0 -0.301 25.0 29.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.005 0.066 -9999.0 0.0 -0.234 30.0 30.0 ITGB7 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.051 0.096 -9999.0 0.0 -0.311 26.0 26.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.033 0.082 -9999.0 0.0 -0.29 26.0 26.0 mol:GDP -0.017 0.124 0.331 4.0 -0.335 35.0 39.0 CDC42/GTP/IQGAP1 0.043 0.014 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.009 0.12 0.342 3.0 -0.309 24.0 27.0 RAC1/GTP/IQGAP1 0.044 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.049 0.012 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.016 0.068 0.219 20.0 -0.225 11.0 31.0 NME1 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.036 0.157 -9999.0 0.0 -0.434 49.0 49.0 regulation of cell-cell adhesion -0.0 0.061 -9999.0 0.0 -0.242 3.0 3.0 WASF2 0.02 0.043 0.117 34.0 -0.11 4.0 38.0 Rap1/GTP 0.013 0.087 0.281 1.0 -0.289 5.0 6.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.06 0.092 -9999.0 0.0 -0.299 21.0 21.0 CCND1 0.017 0.08 0.247 20.0 -0.283 11.0 31.0 VAV2 -0.018 0.192 0.389 3.0 -0.625 19.0 22.0 RAP1/GDP 0.011 0.101 0.311 3.0 -0.334 5.0 8.0 adherens junction assembly -0.033 0.154 -9999.0 0.0 -0.42 49.0 49.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.034 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.045 0.088 -9999.0 0.0 -0.288 24.0 24.0 E-cadherin/beta catenin -0.006 0.089 -9999.0 0.0 -0.335 33.0 33.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.037 0.157 -9999.0 0.0 -0.429 50.0 50.0 PIK3CA 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP 0.013 0.144 0.279 59.0 -0.423 17.0 76.0 E-cadherin/beta catenin/alpha catenin 0.037 0.095 -9999.0 0.0 -0.339 26.0 26.0 ITGAE 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.031 0.167 -9999.0 0.0 -0.448 51.0 51.0