rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	81	AIFM1(3), AKT1(2), AKT2(5), AKT3(4), APAF1(11), ATM(23), BAD(1), BAX(3), BCL2L1(1), BID(4), BIRC2(3), BIRC3(4), CAPN1(8), CAPN2(8), CASP10(2), CASP3(1), CASP6(2), CASP7(2), CASP8(12), CASP9(3), CFLAR(1), CHUK(8), CSF2RB(4), DFFA(4), DFFB(2), FAS(1), FASLG(2), IKBKB(6), IL1A(1), IL1R1(1), IL1RAP(10), IL3(1), IL3RA(3), IRAK1(5), IRAK2(4), IRAK3(2), IRAK4(3), MYD88(1), NFKB1(5), NFKB2(5), NFKBIA(3), NTRK1(8), PIK3CA(352), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R1(16), PIK3R2(4), PIK3R3(3), PIK3R5(5), PPP3CA(5), PPP3CB(3), PPP3CC(1), PPP3R1(1), PRKACA(4), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), RELA(3), RIPK1(5), TNFRSF10A(1), TNFRSF10B(1), TNFRSF10D(1), TNFRSF1A(4), TP53(298), TRAF2(1)	118836923	924	613	483	61	86	233	107	303	194	1	<1.00e-15	<1.00e-15	<1.71e-14
2	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(7), CDKN2A(1), E2F1(5), MDM2(3), MYC(1), PIK3CA(352), PIK3R1(16), POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(4), RB1(22), TBX2(1), TP53(298), TWIST1(2)	27698505	728	568	289	25	58	169	67	269	164	1	<1.00e-15	<1.00e-15	<1.71e-14
3	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(2), ATF2(4), DLD(1), DUSP10(9), DUSP4(1), GAB1(2), GCK(3), IL1R1(1), JUN(3), MAP2K4(32), MAP2K5(1), MAP2K7(1), MAP3K1(79), MAP3K10(3), MAP3K11(5), MAP3K12(7), MAP3K13(10), MAP3K2(3), MAP3K3(1), MAP3K4(8), MAP3K5(12), MAP3K7(3), MAP3K9(6), MAPK10(4), MAPK7(4), MAPK8(2), MAPK9(1), MYEF2(3), NFATC3(9), NR2C2(2), PAPPA(13), SHC1(2), TP53(298), TRAF6(4), ZAK(6)	70625397	545	441	393	34	71	55	68	104	230	17	<1.00e-15	<1.00e-15	<1.71e-14
4	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(11), BAK1(3), BAX(3), BCL2L1(1), BID(4), BIRC2(3), BIRC3(4), CASP2(3), CASP3(1), CASP6(2), CASP7(2), CASP8(12), CASP9(3), FAS(1), FASLG(2), JUN(3), MAP2K4(32), MAP3K1(79), MAPK10(4), MCL1(1), MDM2(3), MYC(1), NFKB1(5), NFKBIA(3), PARP1(6), PRF1(2), RELA(3), RIPK1(5), TNFRSF1A(4), TNFRSF1B(2), TP53(298), TRAF1(2), TRAF2(1)	52194389	509	420	358	24	67	61	66	89	209	17	<1.00e-15	<1.00e-15	<1.71e-14
5	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(2), AKT2(5), AKT3(4), BCR(3), BTK(7), CD19(6), CDKN2A(1), DAPP1(2), FLOT1(2), FLOT2(3), GAB1(2), ITPR1(15), ITPR2(18), ITPR3(14), LYN(6), NR0B2(2), PDK1(2), PHF11(3), PIK3CA(352), PITX2(5), PLCG2(8), PPP1R13B(4), PREX1(10), PTEN(36), PTPRC(8), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), RPS6KB1(4), SAG(3), SYK(4), TEC(6), VAV1(6)	79033718	563	415	259	43	42	178	50	236	56	1	<1.00e-15	<1.00e-15	<1.71e-14
6	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(3), ELK1(4), FOS(1), HRAS(2), JAK1(11), JUN(3), MAP2K1(5), MAP2K4(32), MAP3K1(79), MAPK3(1), MAPK8(2), PDGFRA(6), PIK3CA(352), PIK3R1(16), PLCG1(8), PRKCA(4), RAF1(4), RASA1(2), SHC1(2), SOS1(5), SRF(1), STAT1(4), STAT3(5), STAT5A(6)	50105993	558	407	246	31	24	162	43	216	95	18	<1.00e-15	<1.00e-15	<1.71e-14
7	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	38	AKT1(2), AKT2(5), AKT3(4), BAD(1), BCR(3), BLNK(1), BTK(7), CD19(6), DAG1(2), EPHB2(5), ITPKA(1), ITPKB(8), LYN(6), MAP2K1(5), MAP2K2(2), MAPK1(1), NFAT5(7), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), PI3(1), PIK3CA(352), PIK3CD(6), PIK3R1(16), PLCG2(8), PPP1R13B(4), RAF1(4), SERPINA4(4), SHC1(2), SOS1(5), SOS2(6), SYK(4), VAV1(6)	72298932	501	395	201	41	31	172	42	220	35	1	<1.00e-15	<1.00e-15	<1.71e-14
8	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(2), CREB1(2), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K6(1), MAP3K1(79), MAPK1(1), MAPK14(2), MAPK3(1), NFKB1(5), PIK3CA(352), PIK3R1(16), RB1(22), RELA(3), SP1(6)	28285753	502	394	193	20	13	153	36	205	77	18	<1.00e-15	<1.00e-15	<1.71e-14
9	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	52	ACTA1(3), AGT(3), AKT1(2), CALM2(2), CALR(1), CAMK1(1), CAMK1G(5), CAMK4(5), CREBBP(15), CSNK1A1(4), EDN1(5), F2(2), GATA4(2), GSK3B(2), HAND2(4), HRAS(2), LIF(2), MAP2K1(5), MAPK1(1), MAPK14(2), MAPK3(1), MAPK8(2), MEF2C(4), MYH2(9), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), NKX2-5(1), NPPA(1), PIK3CA(352), PIK3R1(16), PPP3CA(5), PPP3CB(3), PPP3CC(1), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), RAF1(4), RPS6KB1(4), SYT1(2)	70872661	514	392	214	51	27	176	53	223	33	2	2.78e-15	<1.00e-15	<1.71e-14
10	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	AKT1(2), AKT2(5), AKT3(4), BAD(1), BTK(7), CDKN2A(1), DAPP1(2), GSK3A(5), GSK3B(2), IARS(8), INPP5D(4), PDK1(2), PIK3CA(352), PPP1R13B(4), PTEN(36), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), RPS6KB1(4), SFN(1), SHC1(2), SOS1(5), SOS2(6), TEC(6), YWHAB(2), YWHAG(1), YWHAZ(3)	51220932	485	380	182	28	23	165	37	210	49	1	<1.00e-15	<1.00e-15	<1.71e-14
11	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(2), EIF4A1(2), EIF4A2(10), EIF4B(2), EIF4G1(9), EIF4G2(2), EIF4G3(6), MKNK1(2), PDK2(1), PDPK1(2), PIK3CA(352), PIK3R1(16), PPP2CA(3), PTEN(36), RPS6(4), RPS6KB1(4), TSC1(5), TSC2(8)	39466407	466	377	162	21	17	167	32	207	41	2	<1.00e-15	<1.00e-15	<1.71e-14
12	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	DUSP1(1), GORASP1(1), MAP2K4(32), MAP2K7(1), MAPK1(1), MAPK10(4), MAPK13(1), MAPK14(2), MAPK3(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(8), MAPK9(1), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), PIK3CA(352), PIK3CD(6), PIK3R1(16), SYT1(2), TRAF2(1), TRAF3(3), TRAF5(3), TRAF6(4)	44990851	462	377	158	21	24	152	37	203	44	2	<1.00e-15	<1.00e-15	<1.71e-14
13	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(2), AKT2(5), AKT3(4), BAD(1), GSK3A(5), GSK3B(2), IL4R(6), IRS1(4), JAK1(11), JAK3(8), MAP4K1(10), MAPK1(1), MAPK3(1), PDK1(2), PIK3CA(352), PIK3CD(6), PIK3R1(16), PPP1R13B(4), RAF1(4), SHC1(2), SOS1(5), SOS2(6), STAT6(8)	49017656	465	375	165	27	20	159	41	209	34	2	<1.00e-15	<1.00e-15	<1.71e-14
14	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(2), BCAR1(6), CDKN1B(10), ILK(3), ITGB1(5), MAPK1(1), MAPK3(1), PDK2(1), PDPK1(2), PIK3CA(352), PIK3R1(16), PTEN(36), PTK2(7), SHC1(2), SOS1(5)	27045833	449	373	145	19	11	149	31	206	47	5	<1.00e-15	<1.00e-15	<1.71e-14
15	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(5), AKT1(2), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CREB1(2), GNAS(11), HRAS(2), MAPK1(1), MAPK14(2), MAPK3(1), PIK3CA(352), PIK3R1(16), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKCA(4), RPS6KA1(7), RPS6KA5(4), SOS1(5)	40740229	442	369	141	30	22	152	36	202	29	1	<1.00e-15	<1.00e-15	<1.71e-14
16	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(2), APC(23), AXIN1(5), CCND1(1), CD14(1), CTNNB1(2), DVL1(2), FZD1(3), GJA1(4), GNAI1(2), GSK3B(2), IRAK1(5), LBP(1), MYD88(1), NFKB1(5), PDPK1(2), PIK3CA(352), PIK3R1(16), PPP2CA(3), RELA(3), TIRAP(1), TLR4(15)	41861568	451	368	150	36	16	162	33	214	23	3	<1.00e-15	<1.00e-15	<1.71e-14
17	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(6), CRK(1), CXCR4(3), GNAI1(2), GNAQ(1), GNB1(2), HRAS(2), MAP2K1(5), MAPK1(1), MAPK3(1), NFKB1(5), PIK3C2G(8), PIK3CA(352), PIK3R1(16), PLCG1(8), PRKCA(4), PTK2(7), PTK2B(7), RAF1(4), RELA(3)	39884045	438	367	137	21	20	157	31	204	24	2	<1.00e-15	<1.00e-15	<1.71e-14
18	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(4), EIF2B1(3), EIF2B2(2), EIF2B3(2), EIF2B4(3), EIF2B5(4), EIF2S1(3), EIF2S2(3), EIF2S3(2), ELAVL1(4), FLT1(5), FLT4(3), HIF1A(4), HRAS(2), KDR(8), NOS3(3), PIK3CA(352), PIK3R1(16), PLCG1(8), PRKCA(4), PTK2(7), SHC1(2)	48323846	444	364	144	35	17	163	36	202	24	2	<1.00e-15	<1.00e-15	<1.71e-14
19	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(15), EP300(13), IL2RG(2), IL7(1), IL7R(4), JAK1(11), JAK3(8), LCK(2), NMI(2), PIK3CA(352), PIK3R1(16), PTK2B(7), STAT5A(6), STAT5B(5)	40146474	444	362	144	23	20	153	37	204	29	1	<1.00e-15	<1.00e-15	<1.71e-14
20	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(23), ATR(13), BRCA1(14), CCNB1(3), CDC25A(1), CDC25B(3), CDC25C(6), CDC34(1), CDKN1A(1), CHEK1(2), CHEK2(6), EP300(13), MDM2(3), MYT1(10), PRKDC(24), RPS6KA1(7), TP53(298), WEE1(4)	62554744	432	361	292	27	62	59	59	94	158	0	4.11e-15	<1.00e-15	<1.71e-14
21	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(2), AKT2(5), AKT3(4), BPNT1(2), ILK(3), MAPK1(1), MAPK3(1), PDK1(2), PIK3CA(352), PIK3CD(6), PTEN(36), PTK2B(7), SHC1(2), SOS1(5)	28491103	428	361	126	14	13	148	30	200	36	1	<1.00e-15	<1.00e-15	<1.71e-14
22	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(5), ARHGEF1(10), F2(2), F2R(4), GNA12(2), GNA13(1), GNAI1(2), GNAQ(1), GNB1(2), MAP3K7(3), PIK3CA(352), PIK3R1(16), PLCB1(13), PPP1R12B(4), PRKCA(4), PTK2B(7), ROCK1(8)	36500040	436	355	136	26	22	151	37	198	27	1	<1.00e-15	<1.00e-15	<1.71e-14
23	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(3), ELK1(4), FOS(1), HRAS(2), IGF1R(7), IRS1(4), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(2), PIK3CA(352), PIK3R1(16), PTPN11(1), RAF1(4), RASA1(2), SHC1(2), SOS1(5), SRF(1)	34494033	415	349	115	22	12	151	29	199	23	1	<1.00e-15	<1.00e-15	<1.71e-14
24	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(2), DPM2(1), HRAS(2), KLK2(3), NTRK1(8), PIK3CA(352), PIK3R1(16), PLCG1(8), PRKCA(4), SHC1(2), SOS1(5)	22192752	403	349	103	18	11	144	29	198	20	1	<1.00e-15	<1.00e-15	<1.71e-14
25	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(5), AKT1(2), BAD(1), BAX(3), BCL2L1(1), CSF2RB(4), IGF1R(7), IL3(1), IL3RA(3), KIT(8), KITLG(3), PIK3CA(352), PIK3R1(16), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2)	30833911	421	348	121	23	14	155	32	195	24	1	<1.00e-15	<1.00e-15	<1.71e-14
26	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(2), BAD(1), CASP9(3), CHUK(8), GHR(5), NFKB1(5), NFKBIA(3), PDPK1(2), PIK3CA(352), PIK3R1(16), PPP2CA(3), RELA(3)	20152092	403	341	103	15	14	149	28	191	20	1	<1.00e-15	<1.00e-15	<1.71e-14
27	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(2), APAF1(11), ATM(23), BAD(1), BAX(3), BCL2L1(1), BID(4), CASP3(1), CASP6(2), CASP7(2), CASP9(3), EIF2S1(3), PRKCA(4), PTK2(7), STAT1(4), TLN1(16), TP53(298)	39646159	385	338	246	22	57	55	49	81	143	0	<1.00e-15	<1.00e-15	<1.71e-14
28	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(11), ATM(23), BAX(3), CCND1(1), CCNE1(2), CDK2(2), CDK4(1), CDKN1A(1), E2F1(5), MDM2(3), RB1(22), TIMP3(3), TP53(298)	26091072	375	338	235	17	55	38	45	80	157	0	<1.00e-15	<1.00e-15	<1.71e-14
29	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(2), CAT(2), GHR(5), HRAS(2), IGF1R(7), PIK3CA(352), PIK3R1(16), SHC1(2), SOD1(1)	18585708	389	336	89	13	9	145	26	192	16	1	<1.00e-15	<1.00e-15	<1.71e-14
30	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(23), CDC25A(1), CDC25B(3), CDC25C(6), CDK2(2), CDK4(1), CHEK1(2), MYT1(10), RB1(22), TP53(298), WEE1(4)	25775483	372	336	232	14	51	41	45	81	154	0	<1.00e-15	<1.00e-15	<1.71e-14
31	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	ABCB1(9), AKT1(2), ATM(23), BAX(3), CDKN1A(1), CPB2(4), CSNK1A1(4), FHL2(2), HIF1A(4), IGFBP3(1), MAPK8(2), MDM2(3), NFKBIB(2), NQO1(1), TP53(298)	28455003	359	329	220	24	54	42	47	80	136	0	8.44e-12	<1.00e-15	<1.71e-14
32	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(2), IFNG(2), IFNGR1(2), IKBKB(6), JAK2(7), LIN7A(1), NFKB1(5), NFKBIA(3), RB1(22), RELA(3), TNFRSF1A(4), TNFRSF1B(2), TP53(298), USH1C(8), WT1(4)	25124904	369	326	229	15	57	38	46	75	153	0	<1.00e-15	<1.00e-15	<1.71e-14
33	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(23), ATR(13), CDC25C(6), CHEK1(2), CHEK2(6), TP53(298)	23201071	348	325	209	12	51	39	44	79	135	0	<1.00e-15	<1.00e-15	<1.71e-14
34	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(2), CCND1(1), CDK2(2), CDK4(1), CDKN1A(1), CDKN1B(10), CDKN2A(1), CFL1(1), E2F1(5), MDM2(3), PRB1(3), TP53(298)	11159226	328	319	188	11	50	23	41	72	140	2	<1.00e-15	<1.00e-15	<1.71e-14
35	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(8), DNAJC3(4), EIF2S1(3), EIF2S2(3), NFKB1(5), NFKBIA(3), RELA(3), TP53(298)	14486779	327	309	189	8	55	31	43	70	128	0	<1.00e-15	<1.00e-15	<1.71e-14
36	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(5), MAX(2), MYC(1), SP1(6), SP3(7), TP53(298), WT1(4)	9818831	323	309	184	10	50	28	41	75	129	0	<1.00e-15	<1.00e-15	<1.71e-14
37	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(2), EIF2B5(4), EIF2S1(3), EIF2S2(3), EIF2S3(2), GSK3B(2), IGF1R(7), INPPL1(6), PDK2(1), PDPK1(2), PIK3CA(352), PIK3R1(16), PPP2CA(3), PTEN(36), RPS6(4), RPS6KB1(4)	28084281	447	365	144	24	11	160	34	201	38	3	<1.00e-15	1.11e-15	1.75e-14
38	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16	CD28(2), CD3E(3), CD3G(3), CD86(6), CTLA4(1), HLA-DRB1(10), ICOS(3), ITK(7), LCK(2), PIK3CA(352), PIK3R1(16), PTPN11(1)	17747075	406	346	106	19	8	150	32	197	18	1	<1.00e-15	1.11e-15	1.75e-14
39	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(2), PIK3CA(352), PIK3R1(16), PLCB1(13), PLCG1(8), PRKCA(4), VAV1(6)	18608019	401	343	101	15	13	141	28	196	22	1	<1.00e-15	1.11e-15	1.75e-14
40	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(2), ACTR3(2), AKT1(2), AKT2(5), AKT3(4), ANGPTL2(1), ARHGAP1(4), ARHGAP4(6), ARHGEF11(6), BTK(7), CFL1(1), CFL2(1), GDI1(3), GDI2(2), INPPL1(6), ITPR1(15), ITPR2(18), ITPR3(14), LIMK1(8), MYLK(11), MYLK2(5), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PAK7(4), PDK1(2), PIK3CA(352), PIK3CD(6), PIK3CG(5), PIK3R1(16), PITX2(5), PPP1R13B(4), PTEN(36), RACGAP1(3), RHO(2), ROCK1(8), ROCK2(9), RPS4X(2), SAG(3), WASF1(6), WASL(4)	100200544	609	418	304	71	42	192	61	241	70	3	4.57e-13	1.22e-15	1.83e-14
41	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(3), HLA-A(3), IL18(2), ITGB1(5), KLRC1(5), KLRC3(1), KLRD1(1), LAT(1), MAP2K1(5), MAPK3(1), PAK1(4), PIK3CA(352), PIK3R1(16), PTK2B(7), PTPN6(2), SYK(4), VAV1(6)	27000999	418	355	117	15	11	151	33	203	19	1	<1.00e-15	1.22e-15	1.83e-14
42	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	ACOX1(4), APOA1(3), CD36(5), CITED2(2), CPT1B(4), CREBBP(15), DUSP1(1), DUT(1), EHHADH(4), EP300(13), FABP1(2), HSD17B4(8), JUN(3), LPL(1), MAPK1(1), MAPK3(1), MRPL11(2), MYC(1), NCOA1(5), NCOR1(43), NCOR2(8), NFKBIA(3), NR0B2(2), NR1H3(2), NR2F1(1), NRIP1(10), PIK3CA(352), PIK3R1(16), PPARA(4), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKCA(4), PTGS2(5), RB1(22), RELA(3), RXRA(2), SP1(6), SRA1(1), STAT5A(6), STAT5B(5)	88281122	586	425	283	49	35	184	53	222	90	2	<1.00e-15	1.44e-15	2.07e-14
43	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(23), ATR(13), BRCA1(14), BRCA2(17), CHEK1(2), CHEK2(6), FANCA(8), FANCC(4), FANCD2(10), FANCE(2), FANCF(2), FANCG(4), HUS1(2), MRE11A(8), RAD1(1), RAD17(3), RAD50(6), RAD51(2), RAD9A(1), TP53(298)	63698912	426	360	287	26	59	74	51	92	150	0	1.53e-14	1.44e-15	2.07e-14
44	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(2), CCND1(1), CCNE1(2), CDK2(2), CDK4(1), CDK6(2), CDKN1A(1), CDKN1B(10), E2F1(5), HRAS(2), MAPK1(1), MAPK3(1), NFKB1(5), NFKBIA(3), PAK1(4), PIK3CA(352), PIK3R1(16), RAF1(4), RB1(22), RELA(3), TFDP1(3)	28755572	442	369	139	18	18	147	29	198	47	3	<1.00e-15	1.78e-15	2.49e-14
45	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(2), AKT2(5), AKT3(4), BAD(1), BCR(3), BLNK(1), BTK(7), CD19(6), CD22(5), CR2(5), DAG1(2), FLOT1(2), FLOT2(3), GSK3A(5), GSK3B(2), INPP5D(4), ITPR1(15), ITPR2(18), ITPR3(14), LYN(6), MAP4K1(10), MAPK1(1), MAPK3(1), NFATC1(5), NFATC2(4), NR0B2(2), PDK1(2), PIK3CA(352), PIK3CD(6), PIK3R1(16), PLCG2(8), PPP1R13B(4), PPP3CA(5), PPP3CB(3), PPP3CC(1), PTPRC(8), RAF1(4), SHC1(2), SOS1(5), SOS2(6), SYK(4), VAV1(6)	103219435	565	412	264	60	42	187	51	244	40	1	<1.00e-15	1.89e-15	2.51e-14
46	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(2), AKT1(2), ANXA1(5), CALM2(2), GNAS(11), GNB1(2), NFKB1(5), NOS3(3), NPPA(1), NR3C1(3), PIK3CA(352), PIK3R1(16), RELA(3), SYT1(2)	24810982	409	353	109	15	16	147	28	196	21	1	<1.00e-15	1.89e-15	2.51e-14
47	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(7), CALM2(2), ELK1(4), FCER1A(4), FOS(1), HRAS(2), JUN(3), LYN(6), MAP2K1(5), MAP2K4(32), MAP2K7(1), MAP3K1(79), MAPK1(1), MAPK3(1), MAPK8(2), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), PAK2(2), PIK3CA(352), PIK3R1(16), PLA2G4A(7), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(1), RAF1(4), SHC1(2), SOS1(5), SYK(4), SYT1(2), VAV1(6)	59874400	593	430	281	38	30	173	53	225	94	18	<1.00e-15	2.00e-15	2.51e-14
48	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(2), BAD(1), CHRNB1(2), CHRNG(2), MUSK(10), PIK3CA(352), PIK3R1(16), PTK2(7), PTK2B(7), SRC(1), TERT(2)	23334808	402	342	102	16	13	146	28	196	18	1	<1.00e-15	2.00e-15	2.51e-14
49	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(15), DAXX(2), HRAS(2), PAX3(4), PML(3), RARA(1), RB1(22), SIRT1(2), SP100(9), TNFRSF1A(4), TNFRSF1B(2), TP53(298)	25947783	364	325	223	20	56	34	45	81	148	0	<1.00e-15	2.00e-15	2.51e-14
50	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(2), APC(23), AR(6), ASAH1(1), BRAF(5), CCL13(4), CCL15(1), DAG1(2), EGFR(5), GNA11(4), GNAI1(2), GNAQ(1), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), KCNJ3(2), KCNJ5(1), KCNJ9(1), MAPK1(1), MAPK10(4), MAPK14(2), PHKA2(13), PIK3CA(352), PIK3CD(6), PIK3R1(16), PITX2(5), PTX3(1), RAF1(4), SRC(1)	76071109	521	398	219	47	30	178	40	235	36	2	<1.00e-15	2.11e-15	2.55e-14
51	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	24	ABL1(7), ATM(23), ATR(13), CCND1(1), CCNE1(2), CDC25A(1), CDK2(2), CDK4(1), CDK6(2), CDKN1A(1), CDKN1B(10), CDKN2A(1), E2F1(5), GSK3B(2), HDAC1(5), RB1(22), SKP2(2), TFDP1(3), TGFB1(2), TGFB2(1), TGFB3(1), TP53(298)	42338212	405	352	263	26	58	38	51	88	168	2	1.87e-14	2.11e-15	2.55e-14
52	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(2), AKT2(5), AKT3(4), CISH(2), IARS(8), IL13RA1(1), IL2RG(2), IL4(1), IL4R(6), INPP5D(4), JAK1(11), JAK2(7), JAK3(8), NR0B2(2), PI3(1), PIK3CA(352), PPP1R13B(4), RPS6KB1(4), SERPINA4(4), SHC1(2), SOS1(5), SOS2(6), SRC(1), STAT6(8), TYK2(8)	52083735	458	368	157	29	22	157	42	204	31	2	<1.00e-15	2.22e-15	2.63e-14
53	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	99	AKT1(2), AKT2(5), AKT3(4), CASP8(12), CD14(1), CD40(2), CD86(6), CHUK(8), CXCL10(1), FOS(1), IFNA1(1), IFNA10(3), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(3), IFNA2(3), IFNA21(4), IFNA4(2), IFNA6(1), IFNA7(2), IFNA8(2), IFNAR1(2), IFNAR2(1), IKBKB(6), IKBKE(6), IL12B(2), IL6(2), IL8(1), IRAK1(5), IRAK4(3), IRF3(6), IRF5(2), IRF7(1), JUN(3), LBP(1), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K4(32), MAP2K6(1), MAP2K7(1), MAP3K7(3), MAP3K8(4), MAPK1(1), MAPK10(4), MAPK13(1), MAPK14(2), MAPK3(1), MAPK8(2), MAPK9(1), MYD88(1), NFKB1(5), NFKB2(5), NFKBIA(3), PIK3CA(352), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R1(16), PIK3R2(4), PIK3R3(3), PIK3R5(5), RELA(3), RIPK1(5), SPP1(2), STAT1(4), TBK1(1), TICAM1(2), TIRAP(1), TLR1(3), TLR2(3), TLR3(7), TLR4(15), TLR5(4), TLR7(9), TLR8(13), TLR9(2), TRAF3(3), TRAF6(4)	125068107	669	454	365	66	41	214	71	251	89	3	<1.00e-15	2.44e-15	2.84e-14
54	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(2), ACTR3(2), ARPC1A(3), ARPC1B(2), ARPC2(5), PAK1(4), PDGFRA(6), PIK3CA(352), PIK3R1(16), WASL(4)	19586328	396	338	96	18	9	153	25	189	19	1	<1.00e-15	2.55e-15	2.91e-14
55	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(2), ASAH1(1), ATF1(3), BRAF(5), CREB1(2), CREB3(1), CREB5(4), CREBBP(15), CRKL(1), DAG1(2), EGR1(3), EGR2(3), EGR3(4), ELK1(4), FRS2(1), GNAQ(1), JUN(3), MAP1B(8), MAP2K4(32), MAP2K7(1), MAPK1(1), MAPK10(4), MAPK3(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(8), MAPK9(1), NTRK1(8), OPN1LW(3), PIK3C2G(8), PIK3CA(352), PIK3CD(6), PIK3R1(16), PTPN11(1), RPS6KA3(8), SHC1(2), SRC(1), TERF2IP(3), TH(2)	71608009	526	400	220	42	41	166	45	215	58	1	<1.00e-15	2.78e-15	3.05e-14
56	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(2), AKT2(5), AKT3(4), CDKN1A(1), ELK1(4), HRAS(2), MAP2K1(5), MAP2K2(2), NGFR(1), NTRK1(8), PIK3CA(352), PIK3CD(6), SHC1(2), SOS1(5)	22272431	399	345	100	18	14	145	29	195	16	0	<1.00e-15	2.78e-15	3.05e-14
57	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	FN3K(3), IMPA1(3), IMPA2(4), INPP1(1), INPP4A(5), INPP4B(7), INPP5A(2), INPP5B(7), INPP5E(1), INPPL1(6), IPMK(1), ISYNA1(1), ITPK1(1), ITPKA(1), ITPKB(8), MINPP1(3), OCRL(8), PI4KA(10), PI4KB(6), PIK3C3(6), PIK3CA(352), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIP4K2A(2), PIP4K2C(6), PIP5K1A(6), PIP5K1B(2), PIP5K1C(5), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PLCD1(3), PLCD3(2), PLCD4(6), PLCE1(15), PLCG1(8), PLCG2(8), PLCZ1(11), PTEN(36), SYNJ1(4), SYNJ2(4)	104493230	611	436	308	57	46	194	60	233	76	2	<1.00e-15	2.89e-15	3.07e-14
58	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(2), EIF4A1(2), EIF4A2(10), EIF4G1(9), EIF4G2(2), EIF4G3(6), GHR(5), IRS1(4), MAPK1(1), MAPK14(2), MAPK3(1), MKNK1(2), PABPC1(2), PDK2(1), PDPK1(2), PIK3CA(352), PIK3R1(16), PRKCA(4), PTEN(36), RPS6KB1(4)	39629404	463	375	159	21	14	166	31	205	45	2	<1.00e-15	2.89e-15	3.07e-14
59	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(5), AKT1(2), ASAH1(1), GNAI1(2), GNB1(2), ITGAV(7), ITGB3(4), MAPK1(1), MAPK3(1), PDGFRA(6), PIK3CA(352), PIK3R1(16), PLCB1(13), PRKCA(4), PTK2(7), SMPD1(2), SMPD2(2), SPHK1(1), SRC(1)	38773069	429	347	129	25	23	151	29	201	24	1	<1.00e-15	3.00e-15	3.13e-14
60	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(2), ACTR3(2), AKT1(2), ANGPTL2(1), DAG1(2), DGKA(2), ETFA(1), ITGA9(7), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), MAP2K1(5), MAPK1(1), MAPK3(1), NR1I3(2), PAK1(4), PDE3A(12), PDE3B(4), PI3(1), PIK3C2G(8), PIK3CA(352), PIK3CD(6), PIK3R1(16), PSME1(1), RIPK3(4), RPS4X(2), SGCB(2)	70305144	496	385	194	48	24	176	37	225	33	1	5.77e-15	3.11e-15	3.19e-14
61	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(3), EGF(5), EGFR(5), ELK1(4), FOS(1), HRAS(2), JAK1(11), JUN(3), MAP2K1(5), MAP2K4(32), MAP3K1(79), MAPK3(1), MAPK8(2), PIK3CA(352), PIK3R1(16), PLCG1(8), PRKCA(4), RAF1(4), RASA1(2), SHC1(2), SOS1(5), SRF(1), STAT1(4), STAT3(5), STAT5A(6)	53794467	562	409	249	34	24	159	45	220	96	18	<1.00e-15	3.22e-15	3.25e-14
62	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(2), AKT2(5), AKT3(4), BRAF(5), CAB39(1), DDIT4(1), EIF4B(2), FIGF(3), HIF1A(4), MAPK1(1), MAPK3(1), PDPK1(2), PGF(5), PIK3CA(352), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R1(16), PIK3R2(4), PIK3R3(3), PIK3R5(5), PRKAA1(3), PRKAA2(2), RHEB(1), RICTOR(7), RPS6(4), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), RPS6KA6(6), RPS6KB1(4), RPS6KB2(5), STK11(2), TSC1(5), TSC2(8), ULK1(5), ULK2(6), ULK3(5), VEGFA(1), VEGFC(2)	73740492	521	396	220	42	30	185	45	215	45	1	<1.00e-15	3.33e-15	3.31e-14
63	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(3), CRK(1), CRKL(1), DOCK1(8), ELK1(4), FOS(1), GAB1(2), HGF(5), HRAS(2), ITGA1(6), ITGB1(5), JUN(3), MAP2K1(5), MAP2K2(2), MAP4K1(10), MAPK1(1), MAPK3(1), MAPK8(2), MET(10), PAK1(4), PIK3CA(352), PIK3R1(16), PTEN(36), PTK2(7), PTK2B(7), PTPN11(1), RAF1(4), RAP1A(2), RAP1B(1), RASA1(2), SOS1(5), SRC(1), STAT3(5)	65316727	515	398	212	38	31	172	45	215	49	3	<1.00e-15	3.44e-15	3.31e-14
64	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	15	GATA3(100), IL4(1), MAF(1), MAP2K3(3), MAPK14(2), NFATC1(5), NFATC2(4), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2)	14969422	131	121	87	11	5	11	10	8	96	1	0.283	3.44e-15	3.31e-14
65	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(3), DPM2(1), ELK1(4), FOS(1), HRAS(2), JUN(3), KLK2(3), MAP2K1(5), MAPK3(1), MAPK8(2), NGFR(1), PIK3CA(352), PIK3R1(16), PLCG1(8), RAF1(4), SHC1(2), SOS1(5)	26719030	413	352	113	21	15	147	26	201	23	1	<1.00e-15	3.55e-15	3.37e-14
66	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(3), FOS(1), HRAS(2), JAK2(7), JUN(3), MAP2K1(5), MAPK3(1), MPL(2), PIK3CA(352), PIK3R1(16), PLCG1(8), PRKCA(4), RAF1(4), RASA1(2), SHC1(2), SOS1(5), STAT1(4), STAT3(5), STAT5A(6), STAT5B(5), THPO(3)	42970423	440	366	140	23	19	154	31	205	30	1	<1.00e-15	3.66e-15	3.42e-14
67	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(5), CDK5(2), CDK5R1(1), CFL1(1), CHN1(4), LIMK1(8), MAP3K1(79), MYLK(11), NCF2(7), PAK1(4), PDGFRA(6), PIK3CA(352), PIK3R1(16), PLD1(7), PPP1R12B(4), RALBP1(3), RPS6KB1(4), TRIO(13), VAV1(6), WASF1(6)	50705005	539	403	230	41	16	166	52	214	73	18	<1.00e-15	3.89e-15	3.57e-14
68	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT1(2), AKT2(5), AKT3(4), BRD4(3), CAP1(3), CBL(4), CDKN2A(1), F2RL2(2), FLOT1(2), FLOT2(3), GSK3A(5), GSK3B(2), INPPL1(6), IRS1(4), IRS4(7), LNPEP(2), MAPK1(1), MAPK3(1), PARD3(8), PARD6A(1), PDK1(2), PIK3CA(352), PIK3CD(6), PIK3R1(16), PPYR1(4), PTEN(36), RAF1(4), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), RPS6KB1(4), SERPINB6(3), SFN(1), SHC1(2), SLC2A4(3), SORBS1(7), SOS1(5), SOS2(6), YWHAB(2), YWHAG(1), YWHAZ(3)	80216983	543	411	239	49	32	182	39	226	61	3	<1.00e-15	4.00e-15	3.57e-14
69	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(3), INPP1(1), INPP4A(5), INPP4B(7), INPP5A(2), INPPL1(6), ITPKA(1), ITPKB(8), OCRL(8), PIK3C2A(5), PIK3C2B(12), PIK3C2G(8), PIK3CA(352), PIK3CB(8), PIK3CG(5), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PLCD1(3), PLCG1(8), PLCG2(8)	64147146	488	377	188	32	27	174	40	208	38	1	<1.00e-15	4.00e-15	3.57e-14
70	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	33	AKT1(2), BAD(1), BCL2L1(1), CBL(4), CFLAR(1), CRKL(1), E2F1(5), FOS(1), HRAS(2), IL2RA(2), IL2RB(3), IL2RG(2), IRS1(4), JAK1(11), JAK3(8), MAPK1(1), MAPK3(1), MYC(1), NMI(2), PIK3CA(352), PIK3R1(16), PTPN6(2), RAF1(4), RPS6KB1(4), SHC1(2), SOS1(5), STAT5A(6), STAT5B(5), SYK(4)	49764995	453	367	153	27	20	159	37	208	28	1	<1.00e-15	4.11e-15	3.61e-14
71	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(11), BAD(1), BAK1(3), BAX(3), BCL2L1(1), BCL2L11(5), BID(4), BIRC2(3), BIRC3(4), CASP1(3), CASP10(2), CASP2(3), CASP3(1), CASP4(1), CASP6(2), CASP7(2), CASP8(12), CASP9(3), CHUK(8), DFFA(4), DFFB(2), FAS(1), FASLG(2), HELLS(3), IKBKB(6), IRF1(2), IRF2(1), IRF3(6), IRF4(2), IRF5(2), IRF6(3), IRF7(1), JUN(3), LTA(2), MAP2K4(32), MAP3K1(79), MAPK10(4), MDM2(3), MYC(1), NFKB1(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), PLEKHG5(2), PRF1(2), RELA(3), RIPK1(5), TNFRSF10B(1), TNFRSF1A(4), TNFRSF1B(2), TNFRSF21(2), TNFRSF25(2), TP53(298), TP73(2), TRAF1(2), TRAF2(1), TRAF3(3)	79213847	572	442	421	28	76	79	75	99	224	19	<1.00e-15	4.33e-15	3.70e-14
72	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	28	AKT1(2), CABIN1(8), CALM2(2), CAMK1(1), CAMK1G(5), HDAC5(6), IGF1R(7), INSR(11), MAP2K6(1), MAPK14(2), MAPK7(4), MEF2A(6), MEF2C(4), MEF2D(3), NFATC1(5), NFATC2(4), PIK3CA(352), PIK3R1(16), PPP3CA(5), PPP3CB(3), PPP3CC(1), SYT1(2)	47792768	450	356	150	34	12	165	35	212	25	1	<1.00e-15	4.33e-15	3.70e-14
73	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GHR(5), HRAS(2), INSR(11), IRS1(4), JAK2(7), MAP2K1(5), MAPK1(1), MAPK3(1), PIK3CA(352), PIK3R1(16), PLCG1(8), PRKCA(4), PTPN6(2), RAF1(4), RPS6KA1(7), SHC1(2), SLC2A4(3), SOS1(5), SRF(1), STAT5A(6), STAT5B(5)	46398588	451	372	150	25	19	166	29	202	34	1	<1.00e-15	4.55e-15	3.81e-14
74	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(2), AKT2(5), AKT3(4), BTK(7), FCER1A(4), GAB2(5), HRAS(2), IL3(1), IL4(1), INPP5D(4), KRAS(6), LAT(1), LCP2(2), LYN(6), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K4(32), MAP2K6(1), MAP2K7(1), MAPK1(1), MAPK10(4), MAPK13(1), MAPK14(2), MAPK3(1), MAPK8(2), MAPK9(1), MS4A2(3), NRAS(2), PDK1(2), PIK3CA(352), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R1(16), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLCG1(8), PLCG2(8), PRKCA(4), PRKCD(5), PRKCE(8), RAF1(4), SOS1(5), SOS2(6), SYK(4), VAV1(6), VAV2(3), VAV3(7)	101424319	599	429	292	55	41	187	65	234	71	1	<1.00e-15	4.77e-15	3.81e-14
75	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(2), CREB1(2), HRAS(2), MAPK1(1), MAPK3(1), MAPK7(4), MEF2A(6), MEF2C(4), MEF2D(3), NTRK1(8), PIK3CA(352), PIK3R1(16), PLCG1(8), RPS6KA1(7), SHC1(2)	27702805	418	354	117	18	17	147	28	203	22	1	<1.00e-15	4.77e-15	3.81e-14
76	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(3), ELK1(4), FOS(1), HRAS(2), INSR(11), IRS1(4), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(2), PIK3CA(352), PIK3R1(16), PTPN11(1), RAF1(4), RASA1(2), SHC1(2), SLC2A4(3), SOS1(5), SRF(1)	35542088	422	352	122	22	13	155	27	201	25	1	<1.00e-15	4.77e-15	3.81e-14
77	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	57	ALG2(2), BAK1(3), BAX(3), BFAR(3), BTK(7), CAD(17), CASP10(2), CASP3(1), CASP8(12), CD7(1), CSNK1A1(4), DAXX(2), DEDD(1), DEDD2(1), DFFA(4), DIABLO(1), EGFR(5), EPHB2(5), FAF1(7), IL1A(1), IL8(1), MAP2K4(32), MAP2K7(1), MAP3K1(79), MAP3K5(12), MAPK1(1), MAPK10(4), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(8), MAPK9(1), MET(10), NFAT5(7), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), NR0B2(2), PTPN13(16), RALBP1(3), RIPK1(5), ROCK1(8), SMPD1(2), TNFRSF6B(1), TP53(298), TPX2(2), TRAF2(1), TUFM(3)	97277980	601	447	448	52	84	82	77	114	226	18	1.24e-14	4.88e-15	3.81e-14
78	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	AKT1(2), AKT2(5), AKT3(4), BAD(1), BCL2L1(1), CDK2(2), CDKN1B(10), CDKN2A(1), CREB1(2), CREB3(1), CREB5(4), EBP(1), ERBB4(14), F2RL2(2), GAB1(2), GSK3A(5), GSK3B(2), INPPL1(6), IRS1(4), IRS4(7), MET(10), MYC(1), NOLC1(2), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PAK7(4), PARD3(8), PARD6A(1), PDK1(2), PIK3CA(352), PIK3CD(6), PPP1R13B(4), PREX1(10), PTEN(36), PTK2(7), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), RPS6KB1(4), SFN(1), SHC1(2), SLC2A4(3), SOS1(5), SOS2(6), TSC1(5), TSC2(8), YWHAB(2), YWHAG(1), YWHAZ(3)	105376312	598	425	294	65	39	193	56	231	75	4	1.98e-14	4.88e-15	3.81e-14
79	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(12), DIAPH1(5), GSN(2), HRAS(2), ITGA1(6), ITGB1(5), MAP2K1(5), MAPK1(1), MAPK3(1), MYLK(11), PIK3CA(352), PIK3R1(16), PTK2(7), RAF1(4), ROCK1(8), SHC1(2), SRC(1), TLN1(16)	54518490	456	373	156	35	19	161	38	206	31	1	<1.00e-15	4.88e-15	3.81e-14
80	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(2), BAD(1), BCL2L1(1), CASP9(3), CHUK(8), ELK1(4), HRAS(2), MAP2K1(5), MAPK3(1), NFKB1(5), PIK3CA(352), PIK3R1(16), RAF1(4), RALA(1), RALBP1(3), RALGDS(2), RELA(3), RHOA(6)	27431314	419	353	118	21	18	153	28	200	19	1	<1.00e-15	5.00e-15	3.85e-14
81	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(2), BCR(3), CRKL(1), FOS(1), HRAS(2), JAK2(7), JUN(3), MAP2K1(5), MAP2K4(32), MAP3K1(79), MAPK3(1), MAPK8(2), MYC(1), PIK3CA(352), PIK3R1(16), RAF1(4), SOS1(5), STAT1(4), STAT5A(6), STAT5B(5)	39004331	531	405	219	21	20	155	39	211	88	18	<1.00e-15	5.11e-15	3.88e-14
82	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	65	APAF1(11), ATM(23), ATR(13), BAI1(10), BAX(3), BBC3(2), BID(4), CASP3(1), CASP8(12), CASP9(3), CCNB1(3), CCNB3(14), CCND1(1), CCND2(3), CCND3(5), CCNE1(2), CCNE2(4), CCNG2(2), CDK2(2), CDK4(1), CDK6(2), CDKN1A(1), CDKN2A(1), CHEK1(2), CHEK2(6), DDB2(2), EI24(3), FAS(1), GTSE1(10), IGFBP3(1), MDM2(3), MDM4(3), PERP(1), PMAIP1(2), PPM1D(2), PTEN(36), RCHY1(2), RFWD2(4), RPRM(1), RRM2(1), RRM2B(1), SERPINE1(5), SESN2(2), SESN3(1), SFN(1), SIAH1(3), STEAP3(2), THBS1(8), TNFRSF10B(1), TP53(298), TP53I3(3), TP73(2), TSC2(8)	91269850	538	402	394	44	75	83	69	113	196	2	2.33e-15	5.33e-15	4.00e-14
83	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM2(2), CD3E(3), CD3G(3), ELK1(4), FOS(1), HRAS(2), JUN(3), LAT(1), LCK(2), MAP2K1(5), MAP2K4(32), MAP3K1(79), MAPK3(1), MAPK8(2), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), NFKB1(5), NFKBIA(3), PIK3CA(352), PIK3R1(16), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(1), PRKCA(4), PTPN7(5), RAF1(4), RASA1(2), RELA(3), SHC1(2), SOS1(5), SYT1(2), VAV1(6), ZAP70(3)	66976859	595	429	283	47	32	171	52	223	99	18	<1.00e-15	5.55e-15	4.12e-14
84	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(2), EGFR(5), IGF1R(7), MYC(1), POLR2A(6), PPP2CA(3), PRKCA(4), RB1(22), TEP1(16), TERT(2), TNKS(5), TP53(298), XRCC5(3)	40037676	374	333	234	29	52	36	48	87	150	1	7.57e-13	5.66e-15	4.15e-14
85	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(2), BAD(1), HRAS(2), IGF1R(7), IRS1(4), MAP2K1(5), MAPK1(1), MAPK3(1), PIK3CA(352), PIK3R1(16), RAF1(4), SHC1(2), SOS1(5)	26107121	402	344	102	17	9	150	27	197	18	1	<1.00e-15	6.00e-15	4.34e-14
86	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(7), ATM(23), BRCA1(14), CDKN1A(1), CHEK1(2), CHEK2(6), JUN(3), MAPK8(2), MDM2(3), MRE11A(8), NFKB1(5), NFKBIA(3), RAD50(6), RAD51(2), RBBP8(5), RELA(3), TP53(298), TP73(2)	41781739	393	349	254	18	58	56	47	84	148	0	<1.00e-15	7.55e-15	5.41e-14
87	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	20	BAD(1), BAX(3), CASP8(12), MAP2K1(5), MAP2K4(32), MAP3K1(79), MAPK1(1), MAPK3(1), MAPK8(2), NFKB1(5), NSMAF(3), RAF1(4), RELA(3), RIPK1(5), SMPD1(2), TNFRSF1A(4), TRAF2(1)	28536000	163	139	150	9	14	22	15	17	78	17	7.06e-05	8.55e-15	6.05e-14
88	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(3), CASP2(3), CHUK(8), IKBKB(6), JUN(3), LTA(2), MAP2K3(3), MAP2K4(32), MAP2K6(1), MAP3K1(79), MAP4K2(2), MAPK14(2), MAPK8(2), NFKB1(5), NFKBIA(3), RELA(3), RIPK1(5), TANK(3), TNFRSF1A(4), TRAF2(1)	33691738	170	146	157	9	16	23	20	16	78	17	3.07e-05	8.77e-15	6.14e-14
89	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	63	ATM(23), CCNB1(3), CCND1(1), CCND2(3), CCND3(5), CCNE1(2), CCNE2(4), CCNG2(2), CCNH(2), CDC25A(1), CDK2(2), CDK4(1), CDK7(3), CDKN1A(1), CDKN1B(10), CDKN2A(1), CREB3(1), CREB3L1(3), CREB3L3(8), CREB3L4(2), E2F1(5), E2F3(3), E2F4(2), E2F6(2), GBA2(4), MCM2(5), MCM3(4), MCM4(5), MCM5(3), MCM6(4), MCM7(7), MDM2(3), MNAT1(2), MYC(1), MYT1(10), NACA(8), POLA2(6), POLE(10), POLE2(2), PRIM1(1), RB1(22), RBL1(6), RPA1(1), RPA2(2), RPA3(2), TFDP1(3), TFDP2(4), TNXB(16), TP53(298), WEE1(4)	105008716	523	387	380	55	77	81	66	112	184	3	1.58e-11	9.26e-14	6.41e-13
90	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(6), CALM2(2), CRKL(1), GNAQ(1), HRAS(2), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K4(32), MAP3K1(79), MAPK1(1), MAPK14(2), MAPK3(1), MAPK8(2), PAK1(4), PLCG1(8), PRKCA(4), PTK2B(7), RAF1(4), SHC1(2), SOS1(5), SRC(1), SYT1(2)	40229361	179	154	167	17	17	25	19	22	78	18	0.00428	1.26e-12	8.65e-12
91	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(4), CHUK(8), IFNG(2), IKBKB(6), IL4(1), JUN(3), MAP3K1(79), MAP3K5(12), MAP4K5(1), MAPK14(2), MAPK8(2), NFKB1(5), NFKBIA(3), RELA(3), TNFRSF9(2), TNFSF9(1), TRAF2(1)	28418947	135	112	126	11	15	18	13	11	61	17	0.0171	1.56e-12	1.06e-11
92	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	27	ARHGDIB(1), BAG4(1), CASP2(3), CASP3(1), CASP8(12), DFFA(4), DFFB(2), JUN(3), LMNA(4), LMNB1(2), LMNB2(3), MADD(15), MAP2K4(32), MAP3K1(79), MAP3K7(3), MAPK8(2), PAK1(4), PAK2(2), PRKDC(24), RB1(22), RIPK1(5), SPTAN1(13), TNFRSF1A(4), TRAF2(1)	56148816	242	192	227	24	23	36	32	29	105	17	0.000974	2.32e-12	1.55e-11
93	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), CASP10(2), CASP3(1), CASP6(2), CASP7(2), CASP8(12), CFLAR(1), DAXX(2), DFFA(4), DFFB(2), FAF1(7), JUN(3), LMNA(4), LMNB1(2), LMNB2(3), MAP2K4(32), MAP3K1(79), MAP3K7(3), MAPK8(2), PAK1(4), PAK2(2), PRKDC(24), PTPN13(16), RB1(22), RIPK2(2), SPTAN1(13)	61722278	247	190	233	22	20	38	31	33	108	17	0.000587	2.54e-12	1.68e-11
94	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	63	AKT1(2), AKT2(5), AKT3(4), BCL10(3), BLNK(1), BTK(7), CARD11(7), CD19(6), CD22(5), CD72(5), CD79B(2), CHUK(8), CR2(5), FOS(1), GSK3B(2), HRAS(2), IFITM1(1), IKBKB(6), INPP5D(4), JUN(3), KRAS(6), LILRB3(6), LYN(6), MALT1(3), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), NRAS(2), PIK3CA(352), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R1(16), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLCG2(8), PPP3CA(5), PPP3CB(3), PPP3CC(1), PPP3R1(1), PTPN6(2), RASGRP3(2), SYK(4), VAV1(6), VAV2(3), VAV3(7)	104200777	593	421	289	75	44	195	63	235	55	1	2.24e-12	4.23e-12	2.77e-11
95	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	13	CHUK(8), DUSP1(1), IKBKAP(12), IKBKB(6), MAP3K1(79), NFKB1(5), NFKBIA(3), RELA(3), TNFAIP3(3), TRAF3(3), TRAF6(4)	26655488	127	106	119	12	9	17	13	13	57	18	0.0420	2.99e-11	1.94e-10
96	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	32	CD14(1), CHUK(8), ELK1(4), FOS(1), IKBKB(6), IRAK1(5), JUN(3), MAP2K3(3), MAP2K4(32), MAP2K6(1), MAP3K1(79), MAP3K7(3), MAPK14(2), MAPK8(2), MYD88(1), NFKB1(5), NFKBIA(3), PPARA(4), RELA(3), TIRAP(1), TLR10(3), TLR2(3), TLR3(7), TLR4(15), TLR7(9), TLR9(2), TRAF6(4)	51855392	210	171	197	23	20	35	27	25	86	17	0.00313	3.55e-10	2.28e-09
97	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(7), ATM(23), BUB1(3), BUB1B(5), BUB3(3), CCNA2(4), CCNB1(3), CCNB3(14), CCND2(3), CCND3(5), CCNE1(2), CCNE2(4), CCNH(2), CDAN1(2), CDC14A(3), CDC14B(1), CDC20(1), CDC25A(1), CDC25B(3), CDC25C(6), CDC6(4), CDC7(2), CDH1(108), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(1), CHEK1(2), CHEK2(6), DTX4(2), E2F1(5), E2F3(3), E2F4(2), E2F6(2), EP300(13), ESPL1(13), GSK3B(2), HDAC1(5), HDAC2(2), HDAC3(1), HDAC4(6), HDAC5(6), HDAC6(16), HDAC8(3), MAD1L1(4), MAD2L1(4), MAD2L2(3), MCM2(5), MCM3(4), MCM4(5), MCM5(3), MCM6(4), MCM7(7), MDM2(3), MPEG1(4), MPL(2), PLK1(2), PRKDC(24), PTPRA(6), PTTG1(1), PTTG2(1), RB1(22), RBL1(6), SKP2(2), SMAD4(7), TBC1D8(7), TFDP1(3), TGFB1(2), TP53(298), WEE1(4)	160334495	736	502	575	85	89	120	96	129	301	1	2.19e-11	1.46e-08	9.24e-08
98	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(2), AKT2(5), AKT3(4), BAD(1), CASP9(3), HRAS(2), KDR(8), KRAS(6), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK13(1), MAPK14(2), MAPK3(1), MAPKAPK2(1), MAPKAPK3(2), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), NOS3(3), NRAS(2), PIK3CA(352), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R1(16), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLCG1(8), PLCG2(8), PPP3CA(5), PPP3CB(3), PPP3CC(1), PPP3R1(1), PRKCA(4), PRKCG(3), PTGS2(5), PTK2(7), RAF1(4), SH2D2A(4), SHC2(3), SPHK1(1), SPHK2(3), SRC(1), VEGFA(1)	99327602	564	409	261	74	39	188	66	228	42	1	2.01e-11	2.03e-08	1.28e-07
99	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	18	CHUK(8), DUSP1(1), IKBKAP(12), IKBKB(6), LTA(2), MAP3K1(79), NFKB1(5), NFKBIA(3), RELA(3), RIPK1(5), TANK(3), TNFAIP3(3), TNFRSF1B(2), TRAF1(2), TRAF2(1), TRAF3(3)	32255170	138	112	130	14	12	20	18	12	58	18	0.0229	4.13e-08	2.57e-07
100	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(23), CDH1(108), CREBBP(15), EP300(13), MAP2K1(5), MAP3K7(3), MAPK3(1), SKIL(3), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TGFBR2(4)	37181517	183	149	164	20	17	27	16	19	103	1	0.00940	1.03e-07	6.35e-07
101	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(7), ABL2(6), AKT1(2), AKT2(5), AKT3(4), ARAF(6), AREG(1), BAD(1), BRAF(5), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CBL(4), CBLB(14), CBLC(7), CDKN1A(1), CDKN1B(10), CRK(1), CRKL(1), EGF(5), EGFR(5), ELK1(4), ERBB2(23), ERBB3(19), ERBB4(14), GAB1(2), GSK3B(2), HRAS(2), JUN(3), KRAS(6), MAP2K1(5), MAP2K2(2), MAP2K4(32), MAP2K7(1), MAPK1(1), MAPK10(4), MAPK3(1), MAPK8(2), MAPK9(1), MYC(1), NCK1(2), NCK2(1), NRAS(2), NRG1(4), NRG2(4), NRG3(7), NRG4(1), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PAK7(4), PIK3CA(352), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R1(16), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLCG1(8), PLCG2(8), PRKCA(4), PRKCG(3), PTK2(7), RAF1(4), RPS6KB1(4), RPS6KB2(5), SHC1(2), SHC2(3), SHC3(1), SHC4(5), SOS1(5), SOS2(6), SRC(1), STAT5A(6), STAT5B(5), TGFA(1)	144075155	744	462	426	94	65	225	83	270	98	3	2.32e-14	2.09e-06	1.28e-05
102	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(8), IKBKB(6), IL1A(1), IL1R1(1), IRAK1(5), MAP3K1(79), MAP3K7(3), MYD88(1), NFKB1(5), NFKBIA(3), RELA(3), RIPK1(5), TLR4(15), TNFAIP3(3), TNFRSF1A(4), TNFRSF1B(2), TRAF6(4)	33734522	148	117	138	17	13	23	17	18	60	17	0.0407	3.52e-06	2.12e-05
103	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(3), AGTR1(4), ATF2(4), CALM2(2), EGFR(5), ELK1(4), GNAQ(1), HRAS(2), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K4(32), MAP3K1(79), MAPK1(1), MAPK3(1), MAPK8(2), MEF2A(6), MEF2C(4), MEF2D(3), PAK1(4), PRKCA(4), PTK2(7), PTK2B(7), RAF1(4), SHC1(2), SOS1(5), SRC(1), SYT1(2)	49083935	199	162	186	25	20	32	23	29	78	17	0.0167	7.08e-05	0.000423
104	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(5), EGFR(5), MAP2K1(5), MAP3K1(79), MAPK14(2), NCOR2(8), RARA(1), RXRA(2), THRA(3), THRB(2)	24030774	112	99	103	16	5	9	13	14	54	17	0.515	0.000161	0.000953
105	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(7), ACTN1(6), ACTR2(2), ACTR3(2), AKT1(2), AKT2(5), AKT3(4), ANGPTL2(1), ARHGEF6(6), ARHGEF7(8), BCAR1(6), BRAF(5), CAV1(4), CDKN2A(1), CRK(1), CSE1L(6), DOCK1(8), EPHB2(5), GRB7(4), ILK(3), ITGA1(6), ITGA10(10), ITGA11(7), ITGA2(4), ITGA3(1), ITGA4(6), ITGA5(4), ITGA6(4), ITGA7(6), ITGA8(10), ITGA9(7), ITGB3BP(3), MAP2K4(32), MAP2K7(1), MAP3K11(5), MAPK1(1), MAPK10(4), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(8), MAPK9(1), MRAS(2), MYLK(11), MYLK2(5), P4HB(2), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PAK7(4), PIK3CA(352), PIK3CB(8), PKLR(5), PLCG1(8), PLCG2(8), PTEN(36), PTK2(7), RAF1(4), RALA(1), RHO(2), ROCK1(8), ROCK2(9), SHC1(2), SOS1(5), SOS2(6), SRC(1), TERF2IP(3), TLN1(16), TLN2(14), WAS(6), ZYX(2)	173731213	757	475	451	96	73	226	75	275	105	3	8.55e-15	0.000782	0.00459
106	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(2), CDK2(2), CDKN1B(10), CKS1B(1), CUL1(2), E2F1(5), RB1(22), SKP2(2), TFDP1(3)	12474676	49	45	46	7	5	6	3	4	29	2	0.241	0.00331	0.0192
107	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	38	ATF2(4), CREB1(2), DAXX(2), ELK1(4), HMGN1(1), HRAS(2), MAP2K4(32), MAP2K6(1), MAP3K1(79), MAP3K5(12), MAP3K7(3), MAP3K9(6), MAPK14(2), MAPKAPK2(1), MAX(2), MEF2A(6), MEF2C(4), MEF2D(3), MKNK1(2), MYC(1), PLA2G4A(7), RIPK1(5), RPS6KA5(4), SHC1(2), STAT1(4), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TRAF2(1)	52729248	200	157	187	26	20	34	21	31	77	17	0.0320	0.00388	0.0224
108	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(2), CDC34(1), CDK2(2), CUL1(2), E2F1(5), FBXW7(15), RB1(22), TFDP1(3)	12221876	52	48	48	7	10	8	4	6	24	0	0.116	0.00412	0.0235
109	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM2(2), CHUK(8), EGR2(3), EGR3(4), GNAQ(1), MAP3K1(79), MYC(1), NFATC1(5), NFATC2(4), NFKB1(5), NFKBIA(3), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(1), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), RELA(3), SYT1(2), VIP(1), VIPR2(4)	38319162	157	129	149	23	16	24	20	18	62	17	0.113	0.00886	0.0501
110	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1B(8), ACVRL1(1), AKT1(2), AURKB(3), BMPR1A(1), BMPR2(8), BUB1(3), CDKL1(4), CDKL2(2), CDS1(3), CDS2(3), CLK1(2), CLK2(6), CLK4(3), COL4A3BP(4), CSNK2A1(3), CSNK2A2(1), DGKA(2), DGKB(5), DGKD(10), DGKE(4), DGKG(8), DGKH(4), DGKQ(2), DGKZ(1), IMPA1(3), INPP1(1), INPP4A(5), INPP4B(7), INPP5A(2), INPPL1(6), ITPKA(1), ITPKB(8), MAP3K10(3), MOS(3), NEK1(6), NEK3(3), OCRL(8), PAK4(3), PIK3C2A(5), PIK3C2B(12), PIK3C2G(8), PIK3CA(352), PIK3CB(8), PIK3CG(5), PIM2(4), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PLCD1(3), PLCG1(8), PLCG2(8), PLK3(1), PRKACA(4), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKCA(4), PRKCD(5), PRKCE(8), PRKCG(3), PRKCH(3), PRKCQ(9), PRKCZ(2), PRKD1(6), PRKG1(5), RAF1(4), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), RPS6KA4(2), RPS6KB1(4), STK11(2), TGFBR1(4), VRK1(2)	162506471	706	461	403	90	68	215	70	257	93	3	2.42e-13	0.00928	0.0520
111	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYB(1), NFYC(4), RB1(22), SP1(6), SP3(7)	9738225	40	37	38	6	1	6	3	7	23	0	0.272	0.0199	0.110
112	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(8), IFNA1(1), IKBKB(6), IL1A(1), IL1R1(1), IL1RAP(10), IL1RN(2), IL6(2), IRAK1(5), IRAK2(4), IRAK3(2), JUN(3), MAP2K3(3), MAP2K6(1), MAP3K1(79), MAP3K7(3), MAPK14(2), MAPK8(2), MYD88(1), NFKB1(5), NFKBIA(3), RELA(3), TGFB1(2), TGFB2(1), TGFB3(1), TRAF6(4)	42338665	155	130	147	22	15	23	20	18	62	17	0.157	0.0226	0.124
113	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(4), BCR(3), BLNK(1), ELK1(4), FOS(1), HRAS(2), JUN(3), LYN(6), MAP2K1(5), MAP3K1(79), MAPK1(1), MAPK3(1), MAPK8IP3(8), PAPPA(13), RPS6KA1(7), RPS6KA3(8), SHC1(2), SOS1(5), SYK(4), VAV1(6), VAV2(3), VAV3(7)	44570340	173	136	164	25	21	24	22	27	62	17	0.0648	0.0228	0.124
114	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(5), GNAS(11), GNB1(2), PRKACA(4), PRKAR1A(6)	8502224	28	26	28	3	9	3	4	5	7	0	0.0943	0.0426	0.230
115	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(3), CD3G(3)	1706454	6	6	6	0	0	2	1	2	1	0	0.271	0.121	0.650
116	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP3(1), CASP8(12), CFL1(1), CFLAR(1)	5470595	15	14	15	2	1	2	2	5	5	0	0.235	0.146	0.776
117	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(11), BAK1(3), BAX(3), BCL2L1(1), BID(4), BIK(1), BIRC2(3), BIRC3(4), CASP3(1), CASP6(2), CASP7(2), CASP8(12), CASP9(3), DFFA(4), DFFB(2), DIABLO(1)	19332143	57	44	56	3	5	22	8	7	15	0	0.00137	0.155	0.814
118	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM2(2), CALML6(1), CDS1(3), CDS2(3), DGKA(2), DGKB(5), DGKD(10), DGKE(4), DGKG(8), DGKH(4), DGKI(7), DGKQ(2), DGKZ(1), FN3K(3), IMPA1(3), IMPA2(4), INPP1(1), INPP4A(5), INPP4B(7), INPP5A(2), INPP5B(7), INPP5D(4), INPP5E(1), INPPL1(6), ITPK1(1), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), OCRL(8), PI4KA(10), PI4KB(6), PIK3C2A(5), PIK3C2B(12), PIK3C2G(8), PIK3C3(6), PIK3CA(352), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R1(16), PIK3R2(4), PIK3R3(3), PIK3R5(5), PIP4K2A(2), PIP4K2C(6), PIP5K1A(6), PIP5K1B(2), PIP5K1C(5), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PLCD1(3), PLCD3(2), PLCD4(6), PLCE1(15), PLCG1(8), PLCG2(8), PLCZ1(11), PRKCA(4), PRKCG(3), PTEN(36), SYNJ1(4), SYNJ2(4)	179158706	769	495	462	108	69	231	78	278	110	3	1.08e-11	0.202	1.000
119	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT1(2), AKT2(5), AKT3(4), BCL2L1(1), CBL(4), CBLB(14), CBLC(7), CCND1(1), CCND2(3), CCND3(5), CISH(2), CLCF1(1), CNTFR(2), CREBBP(15), CRLF2(1), CSF2RA(3), CSF2RB(4), CSF3(2), CSF3R(6), EP300(13), EPO(1), EPOR(4), GH2(3), GHR(5), IFNA1(1), IFNA10(3), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(3), IFNA2(3), IFNA21(4), IFNA4(2), IFNA6(1), IFNA7(2), IFNA8(2), IFNAR1(2), IFNAR2(1), IFNG(2), IFNGR1(2), IFNK(2), IL10RA(1), IL10RB(3), IL11(1), IL11RA(5), IL12B(2), IL12RB1(7), IL12RB2(4), IL13RA1(1), IL13RA2(5), IL15(3), IL19(1), IL20(1), IL20RA(1), IL21(2), IL21R(2), IL22(2), IL22RA1(4), IL22RA2(3), IL23A(2), IL23R(4), IL24(3), IL28A(1), IL28B(1), IL28RA(2), IL29(2), IL2RA(2), IL2RB(3), IL2RG(2), IL3(1), IL3RA(3), IL4(1), IL4R(6), IL5RA(4), IL6(2), IL6R(5), IL6ST(9), IL7(1), IL7R(4), IL9R(2), IRF9(4), JAK1(11), JAK2(7), JAK3(8), LEP(1), LEPR(7), LIF(2), LIFR(9), MPL(2), MYC(1), OSM(1), OSMR(5), PIAS1(3), PIAS2(7), PIAS3(3), PIAS4(3), PIK3CA(352), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R1(16), PIK3R2(4), PIK3R3(3), PIK3R5(5), PRLR(4), PTPN11(1), PTPN6(2), SOCS2(1), SOCS4(2), SOCS5(1), SOCS7(1), SOS1(5), SOS2(6), SPRED1(7), SPRED2(1), SPRY1(7), SPRY2(2), SPRY3(6), STAM(3), STAM2(4), STAT1(4), STAT2(5), STAT3(5), STAT4(8), STAT5A(6), STAT5B(5), STAT6(8), TPO(8), TSLP(1), TYK2(8)	206764932	838	496	534	110	71	251	118	291	103	4	1.33e-15	0.204	1.000
120	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(7), ESR2(5), ITPKA(1), PDE1A(5), PDE1B(5), PLCB1(13), PLCB2(7), TRH(1), VIP(1)	15482614	45	34	45	2	6	11	9	9	10	0	0.00166	0.230	1.000
121	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	93	AKT1(2), AKT2(5), AKT3(4), BCL10(3), CARD11(7), CBL(4), CBLB(14), CBLC(7), CD28(2), CD3E(3), CD3G(3), CD4(4), CD40LG(1), CD8A(3), CD8B(3), CDK4(1), CHUK(8), CTLA4(1), FOS(1), GRAP2(2), HRAS(2), ICOS(3), IFNG(2), IKBKB(6), IL4(1), ITK(7), JUN(3), KRAS(6), LAT(1), LCK(2), LCP2(2), MALT1(3), MAP3K8(4), NCK1(2), NCK2(1), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), NRAS(2), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PAK7(4), PDCD1(2), PDK1(2), PIK3CA(352), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R1(16), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(1), PPP3R1(1), PRKCQ(9), PTPN6(2), PTPRC(8), RHOA(6), SOS1(5), SOS2(6), TEC(6), VAV1(6), VAV2(3), VAV3(7), ZAP70(3)	141724486	680	450	376	95	52	222	79	249	76	2	9.74e-11	0.236	1.000
122	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNE1(2), CDC34(1), CDK2(2), CUL1(2), E2F1(5), RB1(22), SKP2(2), TFDP1(3)	12523490	39	35	37	6	5	6	3	3	22	0	0.253	0.241	1.000
123	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(4), GNAQ(1), GNB1(2), HTR2C(6), PLCB1(13), TUB(4)	10147428	30	25	30	3	8	5	4	7	6	0	0.0399	0.293	1.000
124	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(3), GSTZ1(1), HGD(4)	3248696	8	8	8	1	1	1	2	3	1	0	0.395	0.304	1.000
125	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(4), GOT1(2), GOT2(1), TAT(3), TYR(5)	6774381	15	14	15	2	4	2	5	2	2	0	0.269	0.321	1.000
126	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(4), IL8(1), SLPI(1)	2293210	6	6	6	1	0	0	3	2	1	0	0.591	0.336	1.000
127	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(23), BMPR1B(6), CCND2(3), CDK4(1), CDKN1B(10), DAZL(1), DMC1(2), EGR1(3), ESR2(5), FSHR(9), GJA4(1), INHA(5), LHCGR(10), MLH1(7), MSH5(7), NCOR1(43), NR5A1(1), NRIP1(10), PGR(6), PRLR(4), PTGER2(2), SMPD1(2), ZP2(4)	48267578	165	121	160	22	19	36	25	25	58	2	0.00433	0.395	1.000
128	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	11	APAF1(11), BAD(1), BAK1(3), BAX(3), BCL10(3), BCL2L1(1), BCL2L11(5), BID(4), CASP9(3), CES1(4)	10857957	38	31	38	4	7	16	5	5	5	0	0.0362	0.398	1.000
129	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), CSF1(5), MST1(7), MST1R(8)	8247485	21	17	20	2	4	8	4	2	3	0	0.0603	0.415	1.000
130	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(3), CCNH(2), CDC25A(1), CDC25B(3), CDC25C(6), CDK7(3), MNAT1(2), SHH(1), XPO1(15)	12399459	36	30	35	3	8	17	4	2	5	0	0.0234	0.416	1.000
131	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	738841	1	1	1	0	0	0	0	1	0	0	0.800	0.422	1.000
132	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(5), SUCLA2(1)	3040859	6	6	6	1	2	1	0	2	1	0	0.484	0.429	1.000
133	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(10), BAIAP2(2), CASP1(3), CASP3(1), CASP7(2), CASP8(12), GAPDH(1), INSR(11), ITCH(4), MAGI1(17), MAGI2(9), RERE(13), WWP1(6), WWP2(12)	33368511	103	69	100	10	13	36	14	27	12	1	0.000192	0.493	1.000
134	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(5), HLCS(3), SPCS3(1)	4475834	9	9	9	0	1	5	3	0	0	0	0.0651	0.496	1.000
135	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(1), CD28(2), CD3E(3), CD3G(3), CD4(4)	4747896	13	12	13	3	1	3	2	3	4	0	0.519	0.532	1.000
136	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	9	B3GALT1(3), B3GALT2(2), B3GALT5(2), B3GNT5(4), FUT1(1), FUT3(3), ST3GAL3(5), ST3GAL4(2)	9401425	22	19	22	2	5	7	7	3	0	0	0.0385	0.557	1.000
137	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), DAG1(2), GNAQ(1), ITPKA(1), ITPKB(8)	7938257	13	13	13	1	2	4	1	4	2	0	0.138	0.571	1.000
138	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(6), CYP2C9(3)	2941407	9	9	9	2	1	4	2	2	0	0	0.487	0.572	1.000
139	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	ARAF(6), BID(4), BRAF(5), CASP3(1), CD244(3), CD48(2), FAS(1), FASLG(2), FCGR3A(4), FCGR3B(2), HLA-A(3), HLA-B(6), HLA-C(9), HLA-G(1), HRAS(2), ICAM1(2), ICAM2(1), IFNA1(1), IFNA10(3), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(3), IFNA2(3), IFNA21(4), IFNA4(2), IFNA6(1), IFNA7(2), IFNA8(2), IFNAR1(2), IFNAR2(1), IFNG(2), IFNGR1(2), ITGAL(5), ITGB2(8), KIR2DL1(3), KIR2DL3(3), KIR2DL4(4), KIR3DL1(3), KIR3DL2(6), KLRC1(5), KLRC3(1), KLRD1(1), KLRK1(2), KRAS(6), LAT(1), LCK(2), LCP2(2), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), MICA(3), MICB(2), NCR1(3), NCR2(3), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), NRAS(2), PAK1(4), PIK3CA(352), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R1(16), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLCG1(8), PLCG2(8), PPP3CA(5), PPP3CB(3), PPP3CC(1), PPP3R1(1), PRF1(2), PRKCA(4), PRKCG(3), PTK2B(7), PTPN11(1), PTPN6(2), RAF1(4), SHC1(2), SHC2(3), SHC3(1), SHC4(5), SOS1(5), SOS2(6), SYK(4), TNFRSF10A(1), TNFRSF10B(1), TNFRSF10D(1), ULBP1(2), ULBP2(3), ULBP3(3), VAV1(6), VAV2(3), VAV3(7), ZAP70(3)	157680677	705	462	400	106	51	236	91	256	69	2	4.48e-11	0.577	1.000
140	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(4), GSS(3), IL8(1), NFKB1(5), NOX1(5), RELA(3), SOD1(1), XDH(9)	14003534	31	30	31	2	5	9	3	7	7	0	0.0155	0.588	1.000
141	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNB1(3), CCND1(1), CCND2(3), CCND3(5), CCNE1(2), CCNH(2), CDC25A(1), CDK2(2), CDK4(1), CDK6(2), CDK7(3), CDKN1A(1), CDKN1B(10), CDKN2A(1), E2F1(5), RB1(22), RBL1(6), TFDP1(3)	22185968	73	66	70	11	7	9	10	7	37	3	0.170	0.597	1.000
142	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), IFNGR1(2), JAK1(11), JAK2(7), STAT1(4)	11988633	26	24	26	2	2	5	6	5	8	0	0.0771	0.642	1.000
143	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(1), EPHX2(4), HSD3B7(1), RDH11(4), RDH12(2), RDH13(2), RDH14(2)	6722905	16	16	16	3	2	3	4	4	3	0	0.274	0.648	1.000
144	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(12), CD44(4), CSF1(5), FCGR3A(4), IL6R(5), SELL(6), SPN(2), TGFB1(2), TGFB2(1), TNFRSF1A(4), TNFRSF1B(2), TNFRSF8(4), TNFSF8(1)	18683248	52	39	50	6	9	13	5	13	12	0	0.0139	0.650	1.000
145	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	1046953	1	1	1	1	0	0	0	0	1	0	0.943	0.671	1.000
146	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	9	BAG4(1), BIRC3(4), CASP8(12), RIPK1(5), TNFRSF1A(4), TNFRSF1B(2), TRAF2(1)	10566472	29	27	28	5	5	9	4	4	7	0	0.179	0.672	1.000
147	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA2(4), CCND1(1), CCNE1(2), CCNE2(4), CDK2(2), CDK4(1), CDKN1B(10), CDKN2A(1), E2F1(5), E2F4(2), PRB1(3)	12108853	35	32	33	7	5	6	3	3	16	2	0.453	0.673	1.000
148	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(1), ADH1C(4), ADH4(1), ADH6(2), ADH7(3), ADHFE1(2)	8274194	13	13	13	2	3	2	7	0	1	0	0.327	0.681	1.000
149	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(3), F13B(5), HSD17B1(1), HSD17B2(4), HSD17B3(2), HSD17B4(8), HSD17B7(1), HSD3B1(3), HSD3B2(4)	11635128	31	31	30	6	3	8	10	6	4	0	0.272	0.701	1.000
150	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(4), CHRNA1(4), SNAP25(4), STX1A(3), VAMP2(1)	4601119	16	14	16	4	3	6	3	3	1	0	0.417	0.702	1.000
151	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(2), NDUFA10(1), NDUFA4(1), NDUFB5(4), NDUFB6(2), NDUFS1(1), NDUFS2(7), NDUFV1(5), NDUFV2(1)	10292419	24	22	24	3	5	4	4	7	4	0	0.195	0.706	1.000
152	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	3	CD28(2), CD4(4), HLA-DRB1(10)	2582311	16	15	16	8	1	2	5	4	4	0	0.911	0.706	1.000
153	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(2), GOT2(1), TAT(3)	3780433	6	5	6	1	1	1	1	1	2	0	0.642	0.711	1.000
154	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(11), ARHGAP5(12), ARHGDIB(1), CASP1(3), CASP10(2), CASP3(1), CASP8(12), CASP9(3), JUN(3), PRF1(2)	18446935	50	42	50	7	6	11	7	8	18	0	0.114	0.716	1.000
155	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(1), DHRS2(4), DHRS3(1), DHRS7(4), DHRSX(1), HSD3B7(1), PON1(4), PON2(1), PON3(4), RDH11(4), RDH12(2), RDH13(2), RDH14(2)	12737805	31	25	31	4	1	9	5	12	4	0	0.0581	0.718	1.000
156	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(6), GAD1(3), PNMT(1), TH(2), TPH1(3)	7961250	15	13	15	2	5	4	2	1	3	0	0.190	0.744	1.000
157	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(23), CDC25A(1), CDC25B(3), CDC25C(6), CHEK1(2), MYT1(10), WEE1(4)	20080255	49	44	48	6	5	18	5	9	12	0	0.105	0.761	1.000
158	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(1), CD3E(3), CD3G(3), CXCR3(6), ETV5(9), IFNG(2), IL12B(2), IL12RB1(7), IL12RB2(4), IL18(2), IL18R1(4), JAK2(7), JUN(3), MAP2K6(1), MAPK14(2), MAPK8(2), STAT4(8), TYK2(8)	27009540	74	61	72	10	12	18	11	17	16	0	0.0299	0.768	1.000
159	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(2), CDK5R1(1), DAB1(5), LRP8(6), RELN(26), VLDLR(9)	20116514	49	38	47	4	9	12	14	7	6	1	0.00616	0.769	1.000
160	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKB1(5), NFKBIA(3), PLCB1(13), PRKCA(4), RELA(3)	11773653	29	24	29	4	6	4	5	5	9	0	0.154	0.788	1.000
161	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1), TPI1(2)	2285289	3	3	3	1	0	1	1	0	1	0	0.761	0.789	1.000
162	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), GALT(2), TGDS(3), UGDH(1), UGP2(4), UXS1(3)	7314842	14	13	14	2	2	7	3	1	1	0	0.287	0.817	1.000
163	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(2), PAPSS1(2), PAPSS2(2), SULT1A2(2), SULT1E1(4), SUOX(4)	8879120	16	14	16	2	3	3	4	4	2	0	0.278	0.832	1.000
164	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(11), BIRC2(3), BIRC3(4), CASP10(2), CASP3(1), CASP7(2), CASP8(12), CASP9(3), DFFA(4), DFFB(2), PRF1(2), SCAP(2), SREBF1(4), SREBF2(6)	24943690	58	47	57	8	6	21	11	6	14	0	0.0313	0.844	1.000
165	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(3), PGLYRP2(1)	2463299	4	4	4	2	0	0	0	2	2	0	0.916	0.856	1.000
166	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP2(2), ACP5(3), ACPP(6), ACPT(1), ENPP1(7), ENPP3(6), FLAD1(8), RFK(1), TYR(5)	14072621	39	33	38	6	8	8	11	6	6	0	0.0839	0.864	1.000
167	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	7	CCL11(1), CCR3(2), HLA-DRB1(10), IL3(1)	3487909	14	13	14	6	1	2	4	4	3	0	0.863	0.868	1.000
168	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1), ALDOA(5), ALDOB(3), ALDOC(2), TPI1(2)	5543262	13	13	13	3	2	7	1	2	1	0	0.375	0.874	1.000
169	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA(2), GBA3(4), GGT1(4), SHMT1(1), SHMT2(4)	8041021	15	14	15	3	3	4	2	4	2	0	0.370	0.874	1.000
170	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), GALT(2), TGDS(3), UGDH(1), UXS1(3)	5788071	10	9	10	2	2	4	3	1	0	0	0.476	0.875	1.000
171	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(3), ARG1(3), GLS(5), GLUD1(2), OAT(2), PRODH(2)	7874276	17	13	17	2	2	5	2	3	5	0	0.276	0.879	1.000
172	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(5), ADRB2(2), CFTR(14), GNAS(11), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), SLC9A3R1(3)	17760037	50	38	50	8	13	9	8	8	12	0	0.0875	0.880	1.000
173	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(5), CREM(3), FHL5(3), FSHR(9), GNAS(11), XPO1(15)	12897294	46	37	45	9	11	10	9	10	6	0	0.314	0.882	1.000
174	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	16	CARS(5), CARS2(5), CDO1(3), CTH(3), GOT1(2), GOT2(1), LDHA(3), LDHC(4), SULT1B1(2), SULT1C2(2), SULT1C4(1), SULT4A1(2)	17542811	33	31	33	4	2	13	4	3	11	0	0.0970	0.884	1.000
175	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(2), COQ5(1), COQ6(4), NDUFA13(1)	6022984	8	8	8	0	1	3	2	2	0	0	0.132	0.887	1.000
176	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(11), JAK2(7), JAK3(8), MAPK1(1), MAPK3(1), STAT3(5), TYK2(8)	16414334	41	35	39	6	9	5	9	7	11	0	0.118	0.892	1.000
177	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(3), LPL(1), NR3C1(3), PPARG(5), RXRA(2)	7579786	14	14	13	3	3	2	4	2	3	0	0.452	0.912	1.000
178	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL13RA2(5), IL4R(6), JAK1(11), JAK2(7), TYK2(8)	14824682	38	34	36	6	4	4	12	8	10	0	0.229	0.915	1.000
179	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL13RA2(5), IL4R(6), JAK1(11), JAK2(7), TYK2(8)	14824682	38	34	36	6	4	4	12	8	10	0	0.229	0.915	1.000
180	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(11), ARHGDIB(1), BIRC2(3), BIRC3(4), CASP1(3), CASP10(2), CASP2(3), CASP3(1), CASP4(1), CASP6(2), CASP7(2), CASP8(12), CASP9(3), DFFA(4), DFFB(2), LMNA(4), LMNB1(2), LMNB2(3), PRF1(2)	27283181	65	51	64	9	6	20	12	10	17	0	0.0686	0.920	1.000
181	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(5), CDO1(3), CSAD(6), GAD1(3), GAD2(3), GGT1(4)	8090557	24	22	24	5	4	10	4	2	4	0	0.270	0.922	1.000
182	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(1), GBA3(4), GGT1(4), SHMT1(1), SHMT2(4)	5971765	14	13	14	4	4	3	2	3	2	0	0.545	0.924	1.000
183	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(2), ST3GAL1(2), ST3GAL2(2), ST3GAL4(2), ST3GAL5(2), ST6GALNAC2(2), ST6GALNAC4(1), ST8SIA1(1)	7663375	14	14	14	3	2	3	4	4	1	0	0.447	0.924	1.000
184	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	7	CARS(5), CTH(3), GOT1(2), GOT2(1), LDHA(3), LDHC(4)	9359890	18	16	18	3	1	6	3	2	6	0	0.324	0.924	1.000
185	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	7	CD28(2), CD4(4), HLA-DRB1(10), IL4(1)	4893098	17	16	17	9	1	2	5	4	5	0	0.958	0.928	1.000
186	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(3), AKR1D1(1), CYP11A1(1), CYP11B1(5), CYP11B2(4), CYP17A1(3), CYP21A2(3), HSD11B1(3), HSD11B2(2), HSD3B1(3), HSD3B2(4)	12832568	32	30	31	6	4	12	8	5	3	0	0.116	0.929	1.000
187	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(3), AKR1D1(1), CYP11A1(1), CYP11B1(5), CYP11B2(4), CYP17A1(3), CYP21A2(3), HSD11B1(3), HSD11B2(2), HSD3B1(3), HSD3B2(4)	12832568	32	30	31	6	4	12	8	5	3	0	0.116	0.929	1.000
188	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(3), OXCT1(5)	4916287	8	6	8	2	1	4	0	3	0	0	0.572	0.932	1.000
189	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS1(6), ALAS2(8), HMBS(3), PPOX(6), UROD(2), UROS(2)	11213226	27	23	26	5	4	6	6	7	4	0	0.298	0.934	1.000
190	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), BCKDK(5), CBS(1), CTH(3), MUT(3)	6896259	13	13	13	3	2	3	2	2	4	0	0.524	0.937	1.000
191	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(3), ASL(4), CPS1(12), GLS(5), GLUD1(2), GOT1(2)	11110445	28	23	28	5	1	5	11	6	5	0	0.318	0.944	1.000
192	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS1(6), ALAS2(8), GATA1(2), HBA2(2), HBB(1), HMBS(3), UROD(2), UROS(2)	11907873	26	22	25	5	5	6	5	6	4	0	0.308	0.951	1.000
193	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	6	FUT1(1), FUT3(3), FUT5(2), FUT6(3), ST3GAL3(5)	6000163	14	14	14	4	4	3	4	2	1	0	0.472	0.952	1.000
194	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	51	ACTG1(8), APAF1(11), ARHGDIB(1), BAG4(1), BID(4), BIRC2(3), BIRC3(4), CASP2(3), CASP3(1), CASP6(2), CASP7(2), CASP8(12), CASP9(3), CFLAR(1), CHUK(8), DAXX(2), DFFA(4), DFFB(2), GSN(2), LMNA(4), LMNB1(2), LMNB2(3), MAP2K7(1), MAP3K1(79), MAP3K5(12), MAPK8(2), MDM2(3), NFKB1(5), NFKBIA(3), NUMA1(8), PAK2(2), PRKCD(5), PRKDC(24), PSEN1(2), PSEN2(4), PTK2(7), RASA1(2), RB1(22), RELA(3), RIPK1(5), SPTAN1(13), TNFRSF1A(4), TNFRSF1B(2), TRAF1(2), TRAF2(1)	99139804	294	206	282	34	40	56	41	39	101	17	0.000253	0.955	1.000
195	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(3), HK1(3), HK2(5), HK3(5), IMPA1(3), PGM1(5), PGM3(2), TGDS(3)	14547260	29	25	29	4	4	4	6	11	4	0	0.0883	0.957	1.000
196	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(3), HK1(3), HK2(5), HK3(5), IMPA1(3), IMPA2(4), ISYNA1(1), PGM1(5), PGM3(2), TGDS(3)	16286781	34	29	34	5	6	4	7	12	5	0	0.0722	0.957	1.000
197	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	FOS(1), HRAS(2), JUN(3), MAP2K1(5), MAPK1(1), MAPK3(1), MYC(1), NFKB1(5), NFKBIA(3), PLCB1(13), PRKCA(4), RAF1(4), RELA(3)	21335411	46	38	46	6	10	10	5	10	11	0	0.0439	0.959	1.000
198	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(4), GBA3(4), LPO(4), MPO(5), PRDX1(3), PRDX2(1), PRDX5(4), TPO(8), TYR(5)	13818300	38	35	38	8	8	8	7	8	7	0	0.244	0.960	1.000
199	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), UGDH(1)	11889086	18	18	17	2	4	3	4	2	5	0	0.144	0.969	1.000
200	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(4), FARSA(3), FARSB(5), GOT1(2), GOT2(1), PAH(3), TAT(3), YARS(4), YARS2(1)	12532648	26	20	26	4	3	11	3	5	4	0	0.211	0.970	1.000
201	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	31	APAF1(11), BID(4), BIRC2(3), BIRC3(4), CASP10(2), CASP3(1), CASP6(2), CASP7(2), CASP8(12), CASP9(3), CFLAR(1), CHUK(8), DFFA(4), DFFB(2), GAS2(3), LMNA(4), NFKB1(5), NFKBIA(3), RELA(3), RIPK1(5), SPTAN1(13), TNFRSF10A(1), TNFRSF10B(1), TNFRSF25(2), TRAF2(1)	47188392	100	73	99	9	19	32	17	11	21	0	0.000287	0.971	1.000
202	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(3), KHK(4), LCT(17), MPI(2), PGM1(5), PYGL(3), PYGM(5), TPI1(2), TREH(2)	19328590	43	39	43	8	8	7	8	11	9	0	0.137	0.972	1.000
203	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CDC25B(3), CDK7(3), CDKN1A(1), CHEK1(2), NEK1(6), WEE1(4)	11028581	20	18	20	3	3	10	0	1	6	0	0.515	0.977	1.000
204	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNAS(11), GNB1(2), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKCA(4)	13298783	33	29	33	6	6	8	6	4	9	0	0.317	0.982	1.000
205	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(4), CDKN1A(1), EPO(1), EPOR(4), GRIN1(3), HIF1A(4), JAK2(7), NFKB1(5), NFKBIA(3), RELA(3)	17959980	35	31	35	5	6	13	3	4	9	0	0.118	0.983	1.000
206	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), ALG5(5), B4GALT1(3), B4GALT3(2), B4GALT5(4), DDOST(2), DPAGT1(4), DPM1(4), FUT8(2), MAN1A1(6), MAN1B1(3), MGAT3(4), MGAT4A(4), MGAT4B(5), MGAT5(3), RPN1(4), RPN2(2), ST6GAL1(3)	26640907	61	44	61	9	8	19	14	10	9	1	0.0346	0.986	1.000
207	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(2), CDK5R1(1), DPM2(1), EGR1(3), HRAS(2), KLK2(3), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), NGFR(1), RAF1(4)	11221001	26	24	25	5	4	7	3	7	5	0	0.241	0.986	1.000
208	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	16	ALOX12(7), ALOX15(4), ALOX15B(5), ALOX5(3), ALOX5AP(1), DPEP1(2), GGT1(4), LTA4H(2), PLA2G2A(1), PLA2G6(2), PTGDS(4), PTGIS(4), PTGS1(5), PTGS2(5), TBXAS1(3)	21297488	52	41	52	8	10	11	13	9	9	0	0.0340	0.987	1.000
209	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(8), CKM(1), FBL(4), GPT(2), LDHA(3), LDHC(4), MAPK14(2), NCL(7)	13000130	31	27	31	6	5	10	8	4	4	0	0.283	0.988	1.000
210	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(2), CFL1(1), GNAQ(1), GNAS(11), GNB1(2), HRAS(2), LIMK1(8), MAP2K1(5), MAPK1(1), MAPK3(1), NOX1(5), PIK3C2G(8), PLCB1(13), PPP1R12B(4), PRKCA(4), PTK2(7), RAF1(4), ROCK2(9)	36460410	89	68	87	10	14	21	14	18	22	0	0.0124	0.989	1.000
211	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(3), BMPR1A(1), BMPR1B(6), BMPR2(8)	8792759	18	16	17	7	1	2	4	5	6	0	0.893	0.990	1.000
212	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(3), CYP11A1(1), CYP11B2(4), CYP17A1(3), HSD11B1(3), HSD11B2(2), HSD3B1(3), HSD3B2(4)	9789566	23	22	22	6	2	7	6	6	2	0	0.322	0.991	1.000
213	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(2), IFNG(2), IFNGR1(2), JAK1(11), JAK2(7), PLA2G2A(1), PTPRU(10), REG1A(1), STAT1(4)	16457271	40	35	40	8	5	7	9	8	10	1	0.352	0.991	1.000
214	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO2(1), ENO3(2), FARS2(4), GOT1(2), GOT2(1), PAH(3), TAT(3), YARS(4)	11950977	20	15	20	3	3	5	5	5	2	0	0.216	0.992	1.000
215	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(2), PSMA2(1), PSMA3(4), PSMA5(2), PSMA6(2), PSMA7(3), PSMB10(1), PSMB4(1), PSMB5(2), PSMB6(2)	11740592	20	20	19	4	2	9	3	5	1	0	0.322	0.993	1.000
216	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(4), IARS(8), LARS(5), LARS2(3), PDHA1(2), PDHA2(4), PDHB(1)	14612241	27	24	27	5	3	10	6	6	2	0	0.258	0.993	1.000
217	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	107	ABL1(7), ANAPC1(11), ANAPC10(1), ANAPC11(1), ANAPC4(4), ANAPC5(5), ANAPC7(5), ATM(23), ATR(13), BUB1(3), BUB1B(5), BUB3(3), CCNA2(4), CCNB1(3), CCNB3(14), CCND1(1), CCND2(3), CCND3(5), CCNE1(2), CCNE2(4), CCNH(2), CDC14A(3), CDC14B(1), CDC16(3), CDC20(1), CDC23(2), CDC25A(1), CDC25B(3), CDC25C(6), CDC6(4), CDC7(2), CDK2(2), CDK4(1), CDK6(2), CDK7(3), CDKN1A(1), CDKN1B(10), CDKN2A(1), CHEK1(2), CHEK2(6), CREBBP(15), CUL1(2), E2F1(5), E2F3(3), EP300(13), ESPL1(13), GSK3B(2), HDAC1(5), HDAC2(2), MAD1L1(4), MAD2L1(4), MAD2L2(3), MCM2(5), MCM3(4), MCM4(5), MCM5(3), MCM6(4), MCM7(7), MDM2(3), PKMYT1(1), PLK1(2), PRKDC(24), PTTG1(1), PTTG2(1), RB1(22), RBL1(6), SFN(1), SKP1(1), SKP2(2), SMAD2(7), SMAD3(4), SMAD4(7), SMC1A(10), SMC1B(6), TFDP1(3), TGFB1(2), TGFB2(1), TGFB3(1), TP53(298), WEE1(4), YWHAB(2), YWHAG(1), YWHAZ(3)	193750022	685	439	541	87	95	128	91	141	227	3	1.58e-09	0.994	1.000
218	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM2(2), CAMK1(1), CAMK1G(5), ELK1(4), FPR1(3), GNB1(2), HRAS(2), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K6(1), MAP3K1(79), MAPK1(1), MAPK14(2), MAPK3(1), NCF1(1), NCF2(7), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), NFKB1(5), NFKBIA(3), PAK1(4), PIK3C2G(8), PLCB1(13), PPP3CA(5), PPP3CB(3), PPP3CC(1), RAF1(4), RELA(3), SYT1(2)	54360283	198	151	189	30	18	39	28	33	63	17	0.0450	0.994	1.000
219	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	CDK5(2), FOSB(2), GRIA2(4)	5072210	8	8	8	3	3	3	2	0	0	0	0.695	0.994	1.000
220	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(4), ALDH1A2(1), BCMO1(5), RDH5(1)	5555924	11	10	11	9	2	1	3	1	4	0	0.995	0.995	1.000
221	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), NRF1(3), UBE2A(2), UBE2C(1), UBE2D1(1), UBE2D2(3), UBE2D3(2), UBE2E1(1), UBE2E3(1), UBE2I(1), UBE2J1(3), UBE2J2(2), UBE2L3(1), UBE2L6(2), UBE3A(3)	14852819	27	25	27	5	3	7	7	4	6	0	0.352	0.995	1.000
222	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(5), GLUD1(2), GLUD2(3)	6372372	10	9	10	3	3	1	1	2	3	0	0.776	0.995	1.000
223	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	CHUK(8), DAXX(2), EGF(5), EGFR(5), ETS1(3), ETS2(7), FOS(1), HRAS(2), IKBKB(6), JUN(3), MAP2K1(5), MAP2K3(3), MAP2K4(32), MAP2K6(1), MAP2K7(1), MAP3K1(79), MAP3K5(12), MAPK1(1), MAPK13(1), MAPK14(2), MAPK3(1), MAPK8(2), NFKB1(5), NFKBIA(3), PPP2CA(3), PRKCA(4), PRKCD(5), PRKCE(8), PRKCG(3), PRKCH(3), PRKCQ(9), RAF1(4), RELA(3), RIPK1(5), SP1(6), TNFRSF1A(4), TNFRSF1B(2), TRAF2(1)	68898074	250	192	235	39	34	38	28	39	93	18	0.0489	0.995	1.000
224	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(7), PNPO(2), PSAT1(1)	6829010	10	9	10	3	2	2	2	1	3	0	0.660	0.996	1.000
225	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(1), PLCD1(3), PRKCA(4), TGM2(7)	6992505	15	13	15	7	3	4	1	1	6	0	0.857	0.996	1.000
226	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(3), CBS(1), CTH(3), GGT1(4), MARS(11), MARS2(1), MAT1A(2), MAT2B(2), PAPSS1(2), PAPSS2(2), SCLY(4), SEPHS1(2)	17363140	37	29	36	7	9	8	9	5	6	0	0.109	0.996	1.000
227	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(4), CD8A(3), CSF1(5), CSF3(2), EPO(1), IL11(1), IL3(1), IL4(1), IL6(2), IL7(1), IL8(1)	8721905	22	20	22	6	3	7	4	1	7	0	0.513	0.996	1.000
228	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(3), CHAT(2), COMT(1), DBH(6), DDC(4), GAD1(3), GAD2(3), MAOA(2), PAH(3), PNMT(1), SLC18A3(3), TH(2), TPH1(3)	19286564	37	34	37	6	11	7	7	5	7	0	0.0923	0.996	1.000
229	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(1), CASP7(2), DFFA(4), DFFB(2), HMGB1(2), HMGB2(3), TOP2A(3), TOP2B(6)	15293450	23	17	22	2	0	10	3	5	5	0	0.162	0.996	1.000
230	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(3), ADCY1(5), CAP1(3), CCNB1(3), CDC25C(6), GNAI1(2), GNAS(11), GNB1(2), HRAS(2), MAPK1(1), MAPK3(1), MYT1(10), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), RPS6KA1(7), SRC(1)	28232840	72	59	71	12	17	17	12	9	16	1	0.0586	0.996	1.000
231	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(3), RAB11A(3), RAB1A(2), RAB27A(1), RAB3A(2), RAB6A(6), RAB9A(1)	6236461	18	15	18	5	1	6	5	2	3	1	0.635	0.996	1.000
232	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(7), ALDH4A1(3), ALDH5A1(2), CAD(17), CPS1(12), EPRS(11), GAD1(3), GAD2(3), GCLC(2), GCLM(2), GFPT1(3), GLS(5), GLUD1(2), GLUL(3), GMPS(5), GOT1(2), GOT2(1), GPT(2), GPT2(3), GSS(3), NADSYN1(6), PPAT(5), QARS(10)	47656764	112	79	112	16	10	39	23	21	19	0	0.00417	0.996	1.000
233	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(12), AGT(3), AGTR1(4), AGTR2(2), BDKRB2(4), KNG1(4), NOS3(3), REN(1)	13588029	33	29	33	8	7	10	5	7	4	0	0.273	0.997	1.000
234	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(1), ADH1C(4), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1)	19212154	35	31	34	6	7	6	13	3	6	0	0.151	0.997	1.000
235	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP2(2), ACP5(3), ACP6(2), ACPP(6), ACPT(1), ENPP1(7), ENPP3(6), FLAD1(8), MTMR1(1), MTMR2(2), MTMR6(3), RFK(1), TYR(5)	21704622	47	38	46	8	9	12	12	7	7	0	0.115	0.997	1.000
236	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(4), CD34(3), CD3E(3), CD3G(3), CD4(4), CD58(2), CD8A(3), CSF3(2), IL3(1), IL6(2), IL8(1), KITLG(3)	9035804	31	27	31	9	2	10	6	4	9	0	0.588	0.998	1.000
237	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), B4GALT1(3), B4GALT3(2), B4GALT5(4), FUT8(2), ST3GAL1(2), ST3GAL2(2), ST3GAL3(5), ST3GAL4(2)	10964043	23	21	23	5	3	10	5	3	2	0	0.341	0.998	1.000
238	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(1), CD36(5), FOS(1), JUN(3), MAPK14(2), THBS1(8)	10269807	20	16	19	8	3	1	2	6	8	0	0.954	0.998	1.000
239	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(4), FDPS(5), IDI1(7), SQLE(2)	4783862	18	17	17	5	4	7	3	1	3	0	0.673	0.998	1.000
240	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	16	CD28(2), CD86(6), HLA-DRB1(10), IFNG(2), IFNGR1(2), IL12B(2), IL12RB1(7), IL12RB2(4), IL18(2), IL18R1(4), IL2RA(2), IL4(1), IL4R(6)	17605712	50	42	50	11	4	11	13	16	6	0	0.300	0.998	1.000
241	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(1), B3GNT2(2), B3GNT7(2), B4GALT1(3), B4GALT3(2), B4GALT4(2), CHST1(4), CHST2(5), CHST4(1), FUT8(2), ST3GAL1(2), ST3GAL2(2), ST3GAL3(5), ST3GAL4(2)	15861121	35	31	35	7	9	9	8	5	4	0	0.174	0.998	1.000
242	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG3(2), ATG5(4), ATG7(5), GABARAP(2), IFNA1(1), IFNA10(3), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(3), IFNA2(3), IFNA21(4), IFNA4(2), IFNA6(1), IFNA7(2), IFNA8(2), IFNG(2), PIK3C3(6), PIK3R4(10), PRKAA1(3), PRKAA2(2), ULK1(5), ULK2(6), ULK3(5)	30206756	82	62	82	13	6	35	17	18	6	0	0.0385	0.998	1.000
243	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), EHHADH(4), HADHA(3)	7027296	8	8	8	3	0	2	3	2	1	0	0.798	0.998	1.000
244	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(8), MAPK14(2), MAPK8(2), NFKB1(5), RELA(3), TNFRSF13B(2), TNFSF13(1), TNFSF13B(1), TRAF2(1), TRAF3(3), TRAF5(3), TRAF6(4)	20720942	35	32	35	5	7	9	5	4	9	1	0.132	0.999	1.000
245	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(2), APEX1(4), CREBBP(15), DFFA(4), DFFB(2), GZMA(2), HMGB2(3), PRF1(2)	15283074	34	29	33	7	6	8	5	7	8	0	0.355	0.999	1.000
246	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(2), HRAS(2), PTK2B(7), SHC1(2), SOS1(5), SRC(1)	12346233	19	19	19	4	5	4	4	3	3	0	0.391	0.999	1.000
247	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(2), CD3E(3), CD3G(3), IFNG(2), IL2RA(2), IL4(1), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TGFBR2(4), TGFBR3(4), TOB1(2)	15467259	31	28	31	7	6	8	4	9	4	0	0.380	0.999	1.000
248	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(4), BLVRB(1), IL10RA(1), IL10RB(3), IL1A(1), IL6(2), JAK1(11), STAT1(4), STAT3(5), STAT5A(6)	17086057	38	33	38	8	5	8	9	9	7	0	0.228	0.999	1.000
249	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(1), CD2(4), CD3E(3), CD3G(3), CD4(4), CXCR3(6), IFNG(2), IL12B(2), IL12RB1(7), IL12RB2(4), JAK2(7), STAT4(8), TYK2(8)	21397280	59	48	57	12	8	12	11	14	14	0	0.256	0.999	1.000
250	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(2), PSMA2(1), PSMA3(4), PSMA5(2), PSMA6(2), PSMA7(3), PSMB4(1), PSMB5(2), PSMB6(2), PSMC3(3), PSMD14(1), RPN1(4), RPN2(2), UBE2A(2), UBE3A(3)	19214893	34	31	33	6	4	12	5	8	4	1	0.230	0.999	1.000
251	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(1), IL22(2), IL22RA1(4), IL22RA2(3), JAK1(11), JAK2(7), JAK3(8), STAT1(4), STAT3(5), STAT5A(6), STAT5B(5), TYK2(8)	26016034	64	55	62	11	14	11	13	10	16	0	0.0683	1.000	1.000
252	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP2(2), ACP5(3), ACP6(2), ACPP(6), ACPT(1), ALPL(1), ALPP(3), ALPPL2(2), CMBL(1), CYP3A4(4), CYP3A43(3), CYP3A5(2), CYP3A7(5), DHRS2(4), DHRS3(1), DHRS7(4), DHRSX(1), PON1(4), PON2(1), PON3(4)	25301573	54	39	53	9	7	16	9	18	4	0	0.0450	1.000	1.000
253	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(2), PSMA2(1), PSMA3(4), PSMA5(2), PSMA6(2), PSMA7(3), PSMB4(1), PSMB5(2), PSMB6(2), PSMC3(3), PSMD1(9), PSMD11(3), PSMD12(3), PSMD13(2), PSMD2(2), PSMD6(3)	23377388	44	38	43	6	6	22	5	6	5	0	0.0647	1.000	1.000
254	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(1), ACADS(2), ACAT1(3), HADHA(3)	7607691	9	9	9	3	1	3	2	3	0	0	0.702	1.000	1.000
255	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(1), ACADS(2), ACADVL(5), ACSL1(3), ACSL3(3), ACSL4(5), CPT1A(6), CPT2(5), EHHADH(4), HADHA(3), SCP2(1), SLC25A20(4)	24001555	42	31	42	7	8	9	10	9	6	0	0.0947	1.000	1.000
256	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	CREB1(2), FOS(1), JUN(3), KEAP1(3), MAPK1(1), MAPK14(2), MAPK8(2), NFE2L2(3), PRKCA(4)	12277885	21	20	21	7	5	4	2	2	7	1	0.825	1.000	1.000
257	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNG(2), IL12B(2), IL15(3), IL16(7), IL18(2), IL1A(1), IL3(1), IL4(1), IL6(2), IL8(1), LTA(2)	13775870	25	21	25	6	3	7	5	7	3	0	0.424	1.000	1.000
258	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(2), CYP2E1(2), NR1I3(2), PTGS1(5), PTGS2(5)	7597151	16	14	16	6	3	3	3	3	4	0	0.765	1.000	1.000
259	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(4), FOS(1), HRAS(2), IL3(1), IL3RA(3), JAK2(7), MAP2K1(5), MAPK3(1), PTPN6(2), RAF1(4), SHC1(2), SOS1(5), STAT5A(6), STAT5B(5)	25078782	48	45	48	8	10	13	6	9	10	0	0.0602	1.000	1.000
260	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(3), IFNG(2), IL12B(2), IL18(2)	4479603	9	9	9	4	1	1	1	5	1	0	0.878	1.000	1.000
261	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(9), CAPN1(8), CDK5(2), CDK5R1(1), CSNK1A1(4), GSK3B(2), MAPT(4), PPP2CA(3)	13265528	33	27	33	7	5	11	5	6	6	0	0.330	1.000	1.000
262	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(15), EP300(13), ESR1(7), MAPK1(1), MAPK3(1), PELP1(7), SRC(1)	21312407	45	38	45	8	8	9	8	11	9	0	0.171	1.000	1.000
263	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(1), BFAR(3), BRAF(5), CREB1(2), CREB3(1), CREB5(4), MAPK1(1), RAF1(4), SNX13(5), SRC(1), TERF2IP(3)	16710165	30	29	30	6	6	8	5	8	3	0	0.309	1.000	1.000
264	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(4), FDPS(5), GGPS1(2), IDI1(7), IDI2(1), SQLE(2)	6354231	21	17	20	6	4	10	3	1	3	0	0.689	1.000	1.000
265	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(8), PRKCA(4), PTK2B(7)	9584224	20	19	20	7	5	5	3	2	5	0	0.733	1.000	1.000
266	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(7), ADC(2), ALDH4A1(3), ALDH5A1(2), CAD(17), CPS1(12), EARS2(3), EPRS(11), GAD1(3), GAD2(3), GCLC(2), GCLM(2), GFPT1(3), GFPT2(9), GLS(5), GLUD1(2), GLUD2(3), GLUL(3), GMPS(5), GNPNAT1(2), GOT1(2), GOT2(1), GPT(2), GPT2(3), GSR(4), GSS(3), NADSYN1(6), NAGK(2), PPAT(5), QARS(10)	56813849	137	93	136	21	14	44	27	27	25	0	0.00336	1.000	1.000
267	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(2), B4GALNT1(1), GLB1(4), HEXA(3), HEXB(3), LCT(17), ST3GAL1(2), ST3GAL2(2), ST3GAL5(2), ST6GALNAC3(4), ST6GALNAC4(1), ST6GALNAC5(2), ST6GALNAC6(4), ST8SIA1(1)	22850437	48	43	48	10	7	13	10	11	7	0	0.196	1.000	1.000
268	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(4), ACO2(5), FH(3), IDH1(5), MDH1(1), SDHB(2), SUCLA2(1)	12982631	21	19	21	5	4	5	3	6	3	0	0.375	1.000	1.000
269	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(23), ASAH1(1), CASP3(1), CERK(2), CREB1(2), CREB3(1), CREB5(4), CXCL2(1), DAG1(2), EPHB2(5), FOS(1), GNAQ(1), ITPKA(1), ITPKB(8), JUN(3), MAP2K4(32), MAP2K7(1), MAPK1(1), MAPK10(4), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(8), MAPK9(1)	38681301	108	87	104	19	19	19	16	20	33	1	0.101	1.000	1.000
270	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(9), ABAT(7), ADSL(3), ADSS(3), AGXT(1), AGXT2(2), ASL(4), ASNS(3), ASPA(4), CAD(17), CRAT(8), DARS(4), DDO(1), GAD1(3), GAD2(3), GOT1(2), GOT2(1), GPT(2), GPT2(3), NARS(1), PC(10)	36910335	91	69	91	15	13	25	26	12	15	0	0.00897	1.000	1.000
271	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(5), ADRB2(2), GNAS(11), PLCE1(15), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), RAP2B(2)	20191676	50	44	50	10	12	8	11	7	12	0	0.247	1.000	1.000
272	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(2), IFNAR2(1), JAK1(11), STAT1(4), STAT2(5), TYK2(8)	15405586	32	29	30	8	4	4	8	7	9	0	0.587	1.000	1.000
273	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(5), CHPT1(4), HEMK1(2), LCMT1(1), LCMT2(10), METTL2B(4), METTL6(1), PCYT1A(2), PCYT1B(6), PRMT2(5), PRMT3(3), PRMT5(6), PRMT6(2), PRMT7(3), PRMT8(4), WBSCR22(2)	19599052	60	48	60	12	6	21	14	9	9	1	0.169	1.000	1.000
274	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	26	BAG4(1), BIRC2(3), BIRC3(4), CASP3(1), CASP8(12), CFLAR(1), JUN(3), MAP2K4(32), MAP3K3(1), MAP3K7(3), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), NR2C2(2), RALBP1(3), RIPK1(5), TNFAIP3(3), TNFRSF1A(4), TNFRSF1B(2), TRAF2(1)	36467116	98	83	93	19	15	22	14	11	36	0	0.170	1.000	1.000
275	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(4), GBA(2), GBA3(4), LPO(4), MPO(5), TPO(8)	11984083	27	25	27	7	7	7	2	6	5	0	0.415	1.000	1.000
276	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(5), DHRS2(4), DHRS3(1), DHRS7(4), DHRSX(1), HEMK1(2), LCMT1(1), LCMT2(10), METTL2B(4), METTL6(1), PRMT2(5), PRMT3(3), PRMT5(6), PRMT6(2), PRMT7(3), PRMT8(4), WBSCR22(2)	20773267	58	45	58	12	6	22	12	8	9	1	0.147	1.000	1.000
277	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(5), EGFR(5), ERBB3(19), NRG1(4), UBE2D1(1)	14745332	34	30	32	8	4	7	12	7	4	0	0.415	1.000	1.000
278	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(9), CS(2), MDH1(1), PC(10), PDHA1(2), SLC25A1(2), SLC25A11(2)	13008135	28	25	28	8	4	3	10	5	6	0	0.508	1.000	1.000
279	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(8), G6PD(4), GCLC(2), GCLM(2), GGT1(4), GPX2(1), GPX3(1), GPX4(1), GPX5(1), GSS(3), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTM4(2), GSTM5(1), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(5), MGST3(2), PGD(4)	25942568	51	39	50	9	6	12	11	15	7	0	0.0891	1.000	1.000
280	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(2), CDK5R1(1), DRD1(1), DRD2(3), GRM1(9), PLCB1(13), PPP2CA(3), PPP3CA(5), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2)	22591539	52	38	52	10	8	16	10	8	10	0	0.0897	1.000	1.000
281	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SEC61A2(4), SRP19(1), SRP54(1), SRP68(3), SRP72(2), SRPR(8)	10924324	20	18	19	5	1	6	1	8	4	0	0.547	1.000	1.000
282	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(1), ACOX1(4), ACOX3(5), ELOVL5(5), ELOVL6(4), FADS1(4), FADS2(7), FASN(14), HADHA(3), SCD(1)	19479458	48	41	48	11	4	18	11	7	8	0	0.147	1.000	1.000
283	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(14), RANGAP1(3)	12199976	18	16	18	4	1	7	2	3	5	0	0.766	1.000	1.000
284	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	8	CAMK1(1), CAMK1G(5), HDAC9(5), MEF2A(6), MEF2C(4), MEF2D(3)	11826597	24	21	24	7	1	5	4	9	5	0	0.613	1.000	1.000
285	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(3), CDC25A(1), CDC25B(3), CDC25C(6), PRKCA(4), PTPRA(6), SRC(1)	13161000	24	23	24	6	4	9	2	4	5	0	0.493	1.000	1.000
286	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(4), ACO2(5), CS(2), DLD(1), DLST(3), FH(3), IDH1(5), IDH3A(2), IDH3B(2), IDH3G(1), MDH1(1), PC(10), PCK1(5), SDHB(2), SUCLA2(1), SUCLG2(1)	29730045	48	38	48	9	9	14	10	11	4	0	0.0705	1.000	1.000
287	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(3), CCL2(1), CSF1(5), IL6(2), LDLR(6), LPL(1)	7488100	18	18	18	6	4	6	4	2	2	0	0.644	1.000	1.000
288	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(1), FUT1(1), GBGT1(2), GLA(5), HEXA(3), HEXB(3), NAGA(1), ST3GAL1(2), ST3GAL2(2), ST3GAL4(2), ST8SIA1(1)	13856861	23	21	23	6	3	9	3	5	3	0	0.498	1.000	1.000
289	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(6), AASDHPPT(4), AASS(5)	10159845	15	13	15	5	2	5	3	2	3	0	0.827	1.000	1.000
290	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), EHHADH(4), HADH(2), HADHA(3), HSD17B10(1), HSD17B4(8), NTAN1(1), SIRT1(2), SIRT2(1), SIRT5(1), SIRT7(4), VNN2(7)	17016995	35	33	35	9	6	13	9	5	2	0	0.487	1.000	1.000
291	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(14), NRG2(4), NRG3(7), PRKCA(4), PSEN1(2)	13134990	31	28	31	8	1	11	6	8	5	0	0.596	1.000	1.000
292	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), B4GALT7(1), HS3ST1(2), HS3ST2(4), HS3ST3A1(1), HS3ST3B1(1), XYLT1(4), XYLT2(5)	8222642	20	19	20	8	7	3	0	6	4	0	0.862	1.000	1.000
293	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), B4GALT7(1), HS3ST1(2), HS3ST2(4), HS3ST3A1(1), HS3ST3B1(1), XYLT1(4), XYLT2(5)	8222642	20	19	20	8	7	3	0	6	4	0	0.862	1.000	1.000
294	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(8), CREBBP(15), EP300(13), HDAC3(1), IKBKB(6), NFKB1(5), NFKBIA(3), RELA(3), RIPK1(5), TNFRSF1A(4), TNFRSF1B(2), TRAF6(4)	31273743	69	53	68	11	16	16	10	10	17	0	0.0598	1.000	1.000
295	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(4), CALCR(2), CALCRL(3), CD97(9), CRHR1(3), CRHR2(1), ELTD1(10), EMR1(5), EMR2(9), GHRHR(5), GIPR(1), GLP1R(2), GLP2R(4), GPR64(9), LPHN1(4), LPHN2(11), LPHN3(8), VIPR1(2), VIPR2(4)	39701150	96	76	96	21	12	27	19	17	20	1	0.0804	1.000	1.000
296	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(4), APOBEC1(2), APOBEC2(2), APOBEC3A(2), APOBEC3B(2), APOBEC3C(2), APOBEC3G(3)	10659633	17	14	17	5	4	4	4	2	3	0	0.639	1.000	1.000
297	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASDHPPT(4), AASS(5)	6933326	9	8	9	5	2	3	2	1	1	0	0.938	1.000	1.000
298	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1)	11262296	22	20	21	8	5	3	6	2	6	0	0.779	1.000	1.000
299	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1)	11262296	22	20	21	8	5	3	6	2	6	0	0.779	1.000	1.000
300	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(3), BDH1(1), HMGCS1(6), HMGCS2(3), OXCT1(5), OXCT2(5)	10438872	23	17	21	7	5	8	1	7	2	0	0.639	1.000	1.000
301	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(3), CARM1(5), CBS(1), CTH(3), GGT1(4), HEMK1(2), LCMT1(1), LCMT2(10), MARS(11), MARS2(1), MAT1A(2), MAT2B(2), METTL2B(4), METTL6(1), PAPSS1(2), PAPSS2(2), PRMT2(5), PRMT3(3), PRMT5(6), PRMT6(2), PRMT7(3), PRMT8(4), SCLY(4), SEPHS1(2), SEPHS2(3), WBSCR22(2)	34674337	88	63	87	17	16	26	21	10	14	1	0.0378	1.000	1.000
302	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(1), AOC2(6), AOC3(3), CES1(4), ESD(2)	8180767	16	12	16	7	1	3	7	4	1	0	0.825	1.000	1.000
303	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(1), LDLR(6), NR0B2(2), NR1H3(2), NR1H4(4), RXRA(2)	7274062	17	17	17	8	6	4	2	4	1	0	0.871	1.000	1.000
304	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(2), CLOCK(3), CRY1(2), CRY2(3), CSNK1E(4), PER1(10)	11816993	24	19	24	7	2	9	4	6	3	0	0.729	1.000	1.000
305	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(3), ADSS(3), IMPDH1(2), POLB(1), POLD1(5), POLG(7), PRPS2(1), RRM1(4), SRM(4)	17643206	30	27	29	8	7	7	7	1	7	1	0.589	1.000	1.000
306	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(1), B3GALNT1(2), B3GALT5(2), FUT1(1), GBGT1(2), GLA(5), HEXA(3), HEXB(3), NAGA(1), ST3GAL1(2), ST3GAL2(2), ST8SIA1(1)	14706593	25	23	25	7	5	10	2	5	3	0	0.529	1.000	1.000
307	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(3), ADORA2A(4), ADORA3(1), P2RY1(4), P2RY2(1), P2RY6(1)	7780486	14	13	14	6	5	0	6	3	0	0	0.667	1.000	1.000
308	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(2), HADH(2), HADHA(3), HADHB(3), HSD17B10(1), HSD17B4(8), PPT1(1), PPT2(3)	11907818	23	20	23	7	4	10	6	2	1	0	0.593	1.000	1.000
309	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(3), ACYP1(2), EHHADH(4), GCDH(2), HADHA(3), SDHB(2)	11260298	16	15	16	5	2	6	3	5	0	0	0.612	1.000	1.000
310	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(1), MTMR2(2), MTMR6(3), NFS1(1), THTPA(3), TPK1(2)	9205688	12	11	12	5	2	7	1	1	1	0	0.907	1.000	1.000
311	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(4), GPD2(3), NDUFA1(2), SDHB(2), SDHD(1), UQCRC1(1)	9409288	13	12	13	5	3	1	2	6	1	0	0.772	1.000	1.000
312	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF3(2), EPO(1), FLT3(4), IL11(1), IL1A(1), IL3(1), IL6(2), KITLG(3), TGFB1(2), TGFB2(1), TGFB3(1)	12163100	19	19	19	8	5	2	5	4	3	0	0.850	1.000	1.000
313	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(3), CHAT(2), CHKA(1), PCYT1A(2), PDHA1(2), PDHA2(4), PEMT(1), SLC18A3(3)	9255670	18	16	18	6	5	3	4	4	2	0	0.632	1.000	1.000
314	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	11	BPNT1(2), CHST11(1), PAPSS1(2), PAPSS2(2), SULT1A1(1), SULT1A2(2), SULT1E1(4), SULT2B1(2), SUOX(4)	12337622	20	18	20	8	5	4	4	4	3	0	0.868	1.000	1.000
315	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL2(1), IFNAR1(2), IFNAR2(1), MAPK8(2), NFKB1(5), RELA(3), TNFRSF11A(2), TRAF6(4)	15288700	21	21	21	8	5	4	3	4	5	0	0.825	1.000	1.000
316	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPL(1), ALPP(3), ALPPL2(2), FPGS(4), GCH1(1)	8298532	11	10	11	5	4	1	3	2	1	0	0.770	1.000	1.000
317	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(3), AMD1(2), BHMT(1), CBS(1), CTH(3), DNMT1(11), DNMT3A(8), DNMT3B(3), MARS(11), MARS2(1), MAT1A(2), MAT2B(2), MTAP(1), MTR(5), SRM(4), TAT(3)	29374078	61	50	60	13	11	15	13	10	10	2	0.163	1.000	1.000
318	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(9), ACO1(4), ACO2(5), ACSS1(1), ACSS2(2), FH(3), IDH1(5), MDH1(1), SUCLA2(1)	19205318	31	26	31	9	4	6	9	7	5	0	0.509	1.000	1.000
319	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(4), ASPH(9), CREB1(2), EDN1(5), EP300(13), EPO(1), HIF1A(4), JUN(3), LDHA(3), NOS3(3), P4HB(2)	24022612	49	39	49	10	4	12	11	10	12	0	0.427	1.000	1.000
320	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(5), PGAP1(10), PIGA(5), PIGB(2), PIGG(7), PIGL(2), PIGM(3), PIGN(4), PIGO(3), PIGQ(4), PIGS(2), PIGT(5), PIGV(2), PIGW(3), PIGZ(3)	35444282	61	47	61	11	8	19	14	14	6	0	0.0383	1.000	1.000
321	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(2), IL2RG(2), IL4(1), IL4R(6), IRS1(4), JAK1(11), JAK3(8), RPS6KB1(4), SHC1(2), STAT6(8)	19962253	48	38	48	11	5	13	12	8	9	1	0.308	1.000	1.000
322	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(5), CTSD(1), ESR1(7), GREB1(6), MTA3(2), PDZK1(1), TUBA8(1)	14243092	23	22	23	7	5	9	3	2	4	0	0.455	1.000	1.000
323	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(5), F2(2), F2R(4), F5(26), F7(2), FGA(7), FGB(1), FGG(7), PROC(3), PROS1(4), SERPINC1(6), TFPI(4)	23248233	71	57	71	16	9	21	18	15	8	0	0.299	1.000	1.000
324	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(1), ACAA2(2), ACAT1(3), EHHADH(4), HADHA(3), HADHB(3)	12158591	16	16	16	5	2	4	5	4	1	0	0.628	1.000	1.000
325	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	21	AOX1(7), BST1(3), CD38(3), ENPP1(7), ENPP3(6), NADK(1), NADSYN1(6), NMNAT1(2), NMNAT2(3), NNT(6), NT5C1A(2), NT5C1B(6), NT5C2(3), NT5C3(4), NT5E(6), NUDT12(2)	30216915	67	54	67	14	7	19	13	17	11	0	0.184	1.000	1.000
326	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(2), AKT2(5), AKT3(4), ARHGEF11(6), DLG4(1), GNA13(1), LPA(16), MAP2K4(32), MAP3K1(79), MAP3K5(12), MAPK8(2), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), PDK1(2), PHKA2(13), PI3(1), PIK3CB(8), PLD1(7), PLD2(2), PLD3(2), PTK2(7), RDX(3), ROCK1(8), ROCK2(9), SERPINA4(4), SRF(1)	69409537	244	183	231	40	33	43	28	30	93	17	0.0819	1.000	1.000
327	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	12	FUCA1(1), FUCA2(3), GLB1(4), HEXA(3), HEXB(3), LCT(17), MAN2C1(6), MANBA(5), NEU1(1), NEU3(2)	21657730	45	40	45	11	5	17	8	8	7	0	0.380	1.000	1.000
328	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), ASNS(3), CA1(3), CA12(1), CA14(4), CA2(2), CA4(2), CA5B(3), CA6(1), CA9(5), CPS1(12), CTH(3), GLS(5), GLUD1(2), GLUL(3), HAL(7)	27192974	57	49	57	12	6	12	17	11	11	0	0.224	1.000	1.000
329	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	DLL1(5), FURIN(3), NOTCH1(8), PSEN1(2)	11132308	18	17	18	6	4	1	8	2	3	0	0.720	1.000	1.000
330	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	31	ABP1(1), ADH1A(1), ADH1C(4), ADH4(1), ADH6(2), ADH7(3), ADHFE1(2), ALDH1A3(7), ALDH3A1(3), ALDH3B2(4), AOC2(6), AOC3(3), AOX1(7), COMT(1), DBH(6), DCT(4), DDC(4), FAH(3), GOT1(2), GOT2(1), GSTZ1(1), HGD(4), HPD(4), MAOA(2), MAOB(4), PNMT(1), TAT(3), TH(2), TPO(8), TYR(5)	43642420	99	74	98	21	24	18	25	16	16	0	0.0825	1.000	1.000
331	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(2), CYP2A13(8), CYP2A6(1), CYP2A7(1), NAT1(2), XDH(9)	11669208	23	20	23	9	4	4	5	7	3	0	0.815	1.000	1.000
332	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(8), G6PD(4), GCLC(2), GCLM(2), GGT1(4), GPX2(1), GPX3(1), GPX4(1), GPX5(1), GSR(4), GSS(3), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTK1(3), GSTM4(2), GSTM5(1), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(5), MGST3(2), TXNDC12(1)	28918353	57	44	56	10	6	12	14	15	10	0	0.0717	1.000	1.000
333	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(3), GCK(3), GFPT1(3), GNE(5), GNPDA2(2), HEXA(3), HEXB(3), HK1(3), HK2(5), HK3(5), PGM3(2), UAP1(3)	24432148	40	35	40	9	7	13	5	11	4	0	0.258	1.000	1.000
334	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	22	ARSA(2), ARSB(3), ARSE(4), ASAH1(1), GAL3ST1(5), GALC(1), GBA(2), GLA(5), GLB1(4), LCT(17), NEU1(1), NEU3(2), PPAP2A(2), PPAP2C(1), SMPD1(2), SMPD2(2), SPTLC1(4), SPTLC2(6), UGCG(1)	32137678	65	52	63	14	14	17	11	18	5	0	0.131	1.000	1.000
335	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(9), AARS2(5), ABAT(7), ACY3(3), ADSL(3), ADSS(3), ADSSL1(1), AGXT(1), AGXT2(2), ASL(4), ASNS(3), ASPA(4), ASS1(1), CAD(17), CRAT(8), DARS(4), DARS2(2), DDO(1), DLAT(2), DLD(1), GAD1(3), GAD2(3), GOT1(2), GOT2(1), GPT(2), GPT2(3), NARS(1), NARS2(2), PC(10), PDHA1(2), PDHA2(4), PDHB(1)	53634764	115	87	115	20	20	29	32	15	19	0	0.0118	1.000	1.000
336	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(5), ATP6V0C(1), CAT(2), EPX(4), LPO(4), MPO(5), PRDX1(3), PRDX2(1), PRDX5(4), SHMT1(1), SHMT2(4), TPO(8)	16839445	42	37	42	11	11	9	5	8	9	0	0.380	1.000	1.000
337	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	21	ABP1(1), ALDH1A3(7), ALDH3A1(3), ALDH3B2(4), AOC2(6), AOC3(3), DDC(4), EPX(4), GOT1(2), GOT2(1), HPD(4), LPO(4), MAOA(2), MAOB(4), MPO(5), PRDX1(3), PRDX2(1), PRDX5(4), TAT(3), TPO(8)	30125091	73	54	72	17	16	14	12	16	15	0	0.212	1.000	1.000
338	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(3), CCR2(7), CCR3(2), CCR4(1), CCR5(1), CCR7(4), CD28(2), CD4(4), CXCR3(6), CXCR4(3), IFNG(2), IFNGR1(2), IL12B(2), IL12RB1(7), IL12RB2(4), IL18R1(4), IL4(1), IL4R(6), TGFB1(2), TGFB2(1), TGFB3(1)	29252883	65	47	65	17	6	14	13	21	11	0	0.375	1.000	1.000
339	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	46	APAF1(11), BAD(1), BAX(3), BCL2A1(1), BCL2L1(1), BCL2L2(1), BOK(1), CASP1(3), CASP10(2), CASP2(3), CASP3(1), CASP4(1), CASP6(2), CASP7(2), CASP8(12), CASP9(3), CD40(2), CD40LG(1), DAXX(2), DFFA(4), DFFB(2), FAS(1), FASLG(2), IKBKE(6), LTA(2), MCL1(1), NFKB1(5), NFKBIA(3), NGFR(1), NR3C1(3), NTRK1(8), PTPN13(16), RIPK1(5), TFG(2), TNFRSF1A(4), TNFRSF1B(2), TRAF1(2), TRAF2(1), TRAF3(3), TRAF6(4)	61468065	130	86	128	23	17	41	20	22	29	1	0.0294	1.000	1.000
340	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	12	CNR1(1), CNR2(1), DNMT1(11), PTAFR(1), PTGDR(2), PTGER2(2), PTGER4(1), PTGFR(1)	14353833	20	18	20	9	5	4	4	3	3	1	0.755	1.000	1.000
341	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(1), ALOX12(7), ALOX15(4), ALOX5(3), CBR1(3), CYP4F2(3), CYP4F3(3), EPX(4), GGT1(4), LPO(4), LTA4H(2), MPO(5), PLA2G1B(1), PLA2G2A(1), PLA2G2E(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PRDX1(3), PRDX2(1), PRDX5(4), PTGDS(4), PTGES2(2), PTGIS(4), PTGS1(5), PTGS2(5), TBXAS1(3), TPO(8)	39598131	96	71	96	18	18	23	19	19	17	0	0.0279	1.000	1.000
342	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(5), CS(2), FH(3), MDH1(1), OGDH(7), SUCLA2(1)	13832182	19	17	19	7	2	7	4	3	3	0	0.725	1.000	1.000
343	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), ASNS(3), CA1(3), CA12(1), CA13(1), CA14(4), CA2(2), CA4(2), CA5B(3), CA6(1), CA9(5), CPS1(12), CTH(3), GLS(5), GLUD1(2), GLUD2(3), GLUL(3), HAL(7)	30311351	61	53	61	13	8	13	17	12	11	0	0.215	1.000	1.000
344	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	14	FUCA1(1), FUCA2(3), GLB1(4), HEXA(3), HEXB(3), LCT(17), MAN2B1(6), MAN2B2(9), MAN2C1(6), MANBA(5), NEU1(1), NEU3(2)	26861042	60	51	60	15	12	19	10	10	9	0	0.278	1.000	1.000
345	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(3), BHMT(1), CBS(1), CTH(3), DNMT1(11), DNMT3A(8), DNMT3B(3), MARS(11), MARS2(1), MAT1A(2), MAT2B(2), MTR(5)	24734248	51	40	50	12	10	13	9	9	8	2	0.262	1.000	1.000
346	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(5), CAT(2), EPX(4), LPO(4), MPO(5), MTHFR(6), SHMT1(1), SHMT2(4), TPO(8)	16454255	39	32	39	10	11	11	3	7	7	0	0.323	1.000	1.000
347	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(2), JAK1(11), JAK2(7), JAK3(8), PIAS1(3), PIAS3(3), PTPRU(10), REG1A(1), SOAT1(2)	19634327	47	39	47	11	9	9	11	7	10	1	0.387	1.000	1.000
348	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(2), MMP14(4), MMP2(4), MMP9(3), RECK(2), TIMP1(2), TIMP3(3)	10797328	20	17	20	9	4	6	3	6	1	0	0.861	1.000	1.000
349	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(3), ELK1(4), FOS(1), HRAS(2), IL2RA(2), IL2RB(3), IL2RG(2), JAK1(11), JAK3(8), JUN(3), LCK(2), MAP2K1(5), MAPK3(1), MAPK8(2), RAF1(4), SHC1(2), SOS1(5), STAT5A(6), STAT5B(5), SYK(4)	33067979	75	61	75	15	15	16	13	16	15	0	0.0932	1.000	1.000
350	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(6), GABARAP(2), GABRA1(4), GABRA2(3), GABRA3(6), GABRA4(7), GABRA5(4), GABRA6(6), GPHN(5), NSF(3), SRC(1), UBQLN1(2)	17314468	49	40	49	13	9	18	9	9	4	0	0.374	1.000	1.000
351	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	107	ACTN1(6), ACTN2(10), ACTN3(7), ACTN4(7), ARHGAP5(12), BCAR1(6), CD99(4), CDH5(1), CLDN1(1), CLDN10(2), CLDN11(1), CLDN14(1), CLDN15(1), CLDN16(2), CLDN17(2), CLDN18(2), CLDN19(2), CLDN2(1), CLDN22(2), CLDN4(1), CLDN6(6), CTNNA1(7), CTNNA2(14), CTNNA3(6), CTNNB1(2), CTNND1(6), CXCR4(3), CYBB(2), ESAM(4), EZR(1), F11R(4), GNAI1(2), GNAI2(2), GNAI3(1), ICAM1(2), ITGA4(6), ITGAL(5), ITGAM(6), ITGB1(5), ITGB2(8), ITK(7), JAM2(1), MAPK13(1), MAPK14(2), MLLT4(20), MMP2(4), MMP9(3), MSN(4), MYL5(3), MYL7(1), MYL9(1), MYLPF(1), NCF1(1), NCF2(7), NCF4(4), NOX1(5), NOX3(2), OCLN(3), PIK3CA(352), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R1(16), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLCG1(8), PLCG2(8), PRKCA(4), PRKCG(3), PTK2(7), PTK2B(7), PTPN11(1), RAP1A(2), RAP1B(1), RAPGEF3(2), RAPGEF4(5), RASSF5(5), RHOA(6), ROCK1(8), ROCK2(9), SIPA1(5), THY1(1), TXK(3), VAV1(6), VAV2(3), VAV3(7), VCAM1(7), VCL(6)	175627125	746	469	443	132	70	224	86	267	97	2	5.68e-07	1.000	1.000
352	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(7), CD38(3), ENPP1(7), ENPP3(6), NADSYN1(6), NMNAT1(2), NMNAT2(3), NNT(6), NT5E(6)	20917447	46	39	46	12	5	14	8	11	8	0	0.452	1.000	1.000
353	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(3), GALNS(2), GLB1(4), GNS(3), GUSB(6), HEXA(3), HEXB(3), IDS(3), IDUA(1), LCT(17), NAGLU(2)	20176770	47	42	47	13	8	13	7	13	6	0	0.511	1.000	1.000
354	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(5), ALDOB(3), ALDOC(2), FBP1(2), G6PD(4), GPI(3), H6PD(3), PFKM(8), PFKP(7), PGD(4), PGLS(2), PGM1(5), PGM3(2), PRPS2(1), RBKS(1), TAL1(1), TALDO1(2), TKT(3)	27853212	58	45	56	14	10	13	8	16	11	0	0.265	1.000	1.000
355	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(2), IL6(2), IL6R(5), JAK1(11), JAK2(7), JAK3(8), PIAS3(3), PTPRU(10), REG1A(1), SRC(1), STAT3(5)	21566510	55	43	55	13	10	7	13	11	13	1	0.362	1.000	1.000
356	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(2), F2R(4), GNAI1(2), GNB1(2), HRAS(2), ITGA1(6), ITGB1(5), MAP2K1(5), MAPK1(1), MAPK3(1), PLA2G4A(7), PLCB1(13), PRKCA(4), PTGS1(5), PTK2(7), RAF1(4), SRC(1), SYK(4), TBXAS1(3)	34813315	78	55	78	15	14	19	19	18	8	0	0.0928	1.000	1.000
357	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(3), APAF1(11), CASP3(1), CASP9(3), DAXX(2), FAS(1), FASLG(2), IL1A(1), MAPKAPK2(1), MAPKAPK3(2)	15453534	27	22	27	9	4	11	5	3	3	1	0.737	1.000	1.000
358	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	83	ATF2(4), BRAF(5), CHUK(8), CREB1(2), DAXX(2), ELK1(4), FOS(1), HRAS(2), IKBKB(6), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K4(32), MAP2K5(1), MAP2K6(1), MAP2K7(1), MAP3K1(79), MAP3K10(3), MAP3K11(5), MAP3K12(7), MAP3K13(10), MAP3K2(3), MAP3K3(1), MAP3K4(8), MAP3K5(12), MAP3K6(3), MAP3K7(3), MAP3K8(4), MAP3K9(6), MAP4K1(10), MAP4K2(2), MAP4K3(2), MAP4K4(13), MAP4K5(1), MAPK1(1), MAPK10(4), MAPK13(1), MAPK14(2), MAPK3(1), MAPK4(6), MAPK6(6), MAPK7(4), MAPK8(2), MAPK9(1), MAPKAPK2(1), MAPKAPK3(2), MAX(2), MEF2A(6), MEF2C(4), MEF2D(3), MKNK1(2), MKNK2(4), MYC(1), NFKB1(5), NFKBIA(3), PAK1(4), PAK2(2), RAF1(4), RELA(3), RIPK1(5), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), RPS6KA4(2), RPS6KA5(4), RPS6KB1(4), RPS6KB2(5), SHC1(2), SP1(6), STAT1(4), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TRAF2(1)	136691422	389	259	373	57	58	84	43	59	128	17	0.000327	1.000	1.000
359	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(3), ALDOA(5), ALDOB(3), ALDOC(2), FBP1(2), FPGT(1), GCK(3), GMDS(2), GMPPA(1), HK1(3), HK2(5), HK3(5), KHK(4), MPI(2), PFKFB3(4), PFKFB4(3), PFKM(8), PFKP(7), PMM1(2), SORD(2), TPI1(2)	34500029	69	55	67	16	12	13	10	22	12	0	0.195	1.000	1.000
360	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	BET1(1), BET1L(1), BNIP1(1), GOSR1(2), SNAP23(2), SNAP25(4), SNAP29(1), STX10(3), STX11(2), STX12(1), STX16(1), STX17(3), STX19(3), STX2(3), STX3(3), STX4(3), STX6(4), STX8(1), TSNARE1(4), USE1(2), VAMP1(1), VAMP2(1), VAMP3(2), VAMP4(1), VAMP5(1), VAMP7(2), VTI1A(1), VTI1B(2)	23398571	56	50	56	13	9	18	11	6	12	0	0.290	1.000	1.000
361	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(3), ELK1(4), EPO(1), EPOR(4), FOS(1), HRAS(2), JAK2(7), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(2), PLCG1(8), PTPN6(2), RAF1(4), SHC1(2), SOS1(5), STAT5A(6), STAT5B(5)	30754287	65	57	65	14	15	19	5	11	15	0	0.181	1.000	1.000
362	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(4), CD28(2), CD3E(3), CD3G(3), CD8A(3), ICAM1(2), ITGAL(5), ITGB2(8), PTPRC(8), THY1(1)	15051669	39	32	39	12	3	12	10	8	6	0	0.532	1.000	1.000
363	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(10), GABBR1(3), GPRC5A(1), GPRC5B(1), GPRC5C(3), GPRC5D(1), GRM1(9), GRM2(3), GRM3(10), GRM4(3), GRM5(4), GRM7(4), GRM8(5)	27403867	57	49	57	15	14	15	13	8	7	0	0.134	1.000	1.000
364	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(3), ELK1(4), FOS(1), HRAS(2), IL6(2), IL6R(5), IL6ST(9), JAK1(11), JAK2(7), JAK3(8), JUN(3), MAP2K1(5), MAPK3(1), PTPN11(1), RAF1(4), SHC1(2), SOS1(5), SRF(1), STAT3(5)	33507537	79	61	79	17	13	14	16	18	18	0	0.219	1.000	1.000
365	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(8), DYRK1B(1), GLI2(12), GLI3(11), GSK3B(2), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), SHH(1), SMO(5), SUFU(3)	21773272	58	47	58	16	12	17	11	8	10	0	0.387	1.000	1.000
366	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(3), GALNS(2), GLB1(4), GNS(3), GUSB(6), HEXA(3), HEXB(3), HGSNAT(6), HPSE(6), HPSE2(5), HYAL2(3), IDS(3), IDUA(1), LCT(17), NAGLU(2), SPAM1(4)	28945867	71	62	72	19	12	21	10	17	11	0	0.419	1.000	1.000
367	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(4), ACOX3(5), FADS2(7), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2)	14918453	35	30	35	10	2	12	10	9	2	0	0.511	1.000	1.000
368	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(5), ANXA3(3), ANXA4(3), ANXA5(1), ANXA6(5), CYP11A1(1), EDN1(5), EDNRA(3), EDNRB(2), HPGD(1), HSD11B1(3), HSD11B2(2), PLA2G4A(7), PTGDR(2), PTGDS(4), PTGER2(2), PTGER4(1), PTGFR(1), PTGIS(4), PTGS1(5), PTGS2(5), S100A6(1), TBXAS1(3)	29076974	69	50	69	17	12	20	9	16	12	0	0.334	1.000	1.000
369	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(8), CREBBP(15), DUSP1(1), EP300(13), IKBKB(6), IL8(1), MAP2K3(3), MAP2K6(1), MAP3K7(3), MAPK14(2), MYD88(1), NFKB1(5), NFKBIA(3), NR3C1(3), RELA(3), TGFBR1(4), TGFBR2(4), TLR2(3)	42126209	79	59	79	16	16	19	11	13	20	0	0.176	1.000	1.000
370	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	128	ACACA(13), ACACB(13), AKT1(2), AKT2(5), AKT3(4), ARAF(6), BAD(1), BRAF(5), CALM2(2), CALML6(1), CBL(4), CBLB(14), CBLC(7), CRK(1), CRKL(1), ELK1(4), EXOC7(6), FASN(14), FBP1(2), FLOT1(2), FLOT2(3), FOXO1(2), G6PC(2), G6PC2(3), GCK(3), GSK3B(2), GYS1(8), GYS2(1), HRAS(2), IKBKB(6), INPP5D(4), INSR(11), IRS1(4), IRS4(7), KRAS(6), LIPE(5), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK10(4), MAPK3(1), MAPK8(2), MAPK9(1), MKNK1(2), MKNK2(4), NRAS(2), PCK1(5), PCK2(4), PDE3A(12), PDE3B(4), PDPK1(2), PFKL(1), PFKM(8), PFKP(7), PHKA1(8), PHKA2(13), PHKB(4), PHKG2(1), PIK3CA(352), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R1(16), PIK3R2(4), PIK3R3(3), PIK3R5(5), PKLR(5), PPARGC1A(6), PPP1CB(1), PPP1R3A(13), PPP1R3B(2), PPP1R3C(3), PRKAA1(3), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKACA(4), PRKACB(1), PRKACG(3), PRKAG1(2), PRKAG2(2), PRKAG3(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKCI(1), PRKCZ(2), PRKX(5), PTPRF(11), PYGB(5), PYGL(3), PYGM(5), RAF1(4), RAPGEF1(5), RHEB(1), RHOQ(2), RPS6(4), RPS6KB1(4), RPS6KB2(5), SH2B2(1), SHC1(2), SHC2(3), SHC3(1), SHC4(5), SLC2A4(3), SOCS2(1), SOCS4(2), SORBS1(7), SOS1(5), SOS2(6), SREBF1(4), TRIP10(4), TSC1(5), TSC2(8)	221903996	845	504	538	143	84	270	96	300	94	1	1.41e-09	1.000	1.000
371	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(3), ARG1(3), ARG2(2), ASL(4), ASS1(1), CKB(1), CKM(1), CKMT1A(1), CKMT1B(1), CKMT2(5), CPS1(12), DAO(1), EPRS(11), GAMT(1), GATM(3), GLUD1(2), GLUD2(3), GOT1(2), GOT2(1), LAP3(3), NOS1(13), NOS3(3), OAT(2), OTC(3), P4HA1(3), P4HA2(5), P4HA3(4), PARS2(2), PRODH(2), PYCR1(1), PYCR2(2), PYCRL(1), RARS(5), RARS2(3)	50673716	110	80	109	22	22	30	34	13	11	0	0.0391	1.000	1.000
372	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(1), ACY1(2), ADC(2), AGMAT(4), ALDH18A1(4), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), AMD1(2), AOC2(6), AOC3(3), ARG1(3), ARG2(2), ASL(4), ASS1(1), CPS1(12), GATM(3), MAOA(2), MAOB(4), NAGS(1), OTC(3), SAT1(3), SAT2(2), SRM(4)	41605856	85	61	84	19	9	15	27	20	14	0	0.158	1.000	1.000
373	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(5), CHIA(3), CHIT1(3), CMAS(3), CTBS(1), CYB5R1(4), GFPT1(3), GFPT2(9), GNE(5), GNPDA2(2), GNPNAT1(2), HEXA(3), HEXB(3), HK1(3), HK2(5), HK3(5), MTMR1(1), MTMR2(2), MTMR6(3), NAGK(2), NANS(1), NPL(2), PGM3(2), UAP1(3)	41264196	75	57	74	16	11	24	13	16	11	0	0.184	1.000	1.000
374	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(4), DHRS3(1), DHRS7(4), DHRSX(1), ESCO1(4), ESCO2(1), PNPLA3(3), SH3GLB1(2)	23510977	20	17	20	6	1	8	1	7	2	1	0.747	1.000	1.000
375	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(1), BTK(7), CALM2(2), CD79B(2), ELK1(4), FOS(1), HRAS(2), JUN(3), LYN(6), MAP2K1(5), MAP3K1(79), MAPK14(2), MAPK3(1), MAPK8(2), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(1), PRKCA(4), RAF1(4), SHC1(2), SOS1(5), SYK(4), SYT1(2), VAV1(6)	53242104	187	149	179	36	20	30	25	35	60	17	0.356	1.000	1.000
376	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(5), ALDOB(3), ALDOC(2), DERA(2), FBP1(2), G6PD(4), GPI(3), H6PD(3), PFKL(1), PFKM(8), PFKP(7), PGD(4), PGLS(2), PGM1(5), PGM3(2), PRPS2(1), RBKS(1), TALDO1(2), TKT(3), TKTL1(3), TKTL2(3)	33744267	66	51	64	17	10	14	10	17	15	0	0.351	1.000	1.000
377	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(5), CS(2), DLAT(2), DLD(1), DLST(3), FH(3), IDH3A(2), IDH3B(2), IDH3G(1), MDH1(1), OGDH(7), PC(10), PDHA1(2), PDHA2(4), PDHB(1), PDHX(3), PDK1(2), PDK2(1), PDK4(4), PDP2(2), SDHB(2), SDHD(1), SUCLA2(1), SUCLG2(1)	40969682	63	50	63	14	14	15	14	15	5	0	0.129	1.000	1.000
378	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(4), AADAC(5), ABAT(7), ACADS(2), ACAT1(3), ACSM1(4), AKR1B10(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH5A1(2), ALDH9A1(1), BDH1(1), DDHD1(4), EHHADH(4), GAD1(3), GAD2(3), HADH(2), HADHA(3), HMGCS1(6), HMGCS2(3), HSD17B10(1), HSD17B4(8), HSD3B7(1), ILVBL(5), L2HGDH(2), OXCT1(5), OXCT2(5), PDHA1(2), PDHA2(4), PDHB(1), PLA1A(3), PPME1(2), RDH11(4), RDH12(2), RDH13(2), RDH14(2)	58178755	123	91	120	28	21	32	24	29	17	0	0.106	1.000	1.000
379	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	36	ANKHD1(15), EEF1A2(3), EEF1B2(2), EEF1D(3), EEF1G(1), EEF2(5), EEF2K(6), EIF1AX(3), EIF2AK1(5), EIF2AK2(3), EIF2AK3(4), EIF2B1(3), EIF2B2(2), EIF2B3(2), EIF2B4(3), EIF2B5(4), EIF2S1(3), EIF2S2(3), EIF2S3(2), EIF4A1(2), EIF4A2(10), EIF4G1(9), EIF4G3(6), EIF5(2), EIF5B(5), ETF1(3), GSPT2(5), KIAA0664(7), PABPC1(2), PABPC3(8)	63025230	131	93	131	25	24	42	20	20	25	0	0.0749	1.000	1.000
380	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	40	ABP1(1), ACY3(3), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH3B2(4), ALDH9A1(1), AMDHD1(4), AOC2(6), AOC3(3), ASPA(4), CARM1(5), CNDP1(7), DDC(4), FTCD(2), HAL(7), HARS(1), HEMK1(2), HNMT(2), LCMT1(1), LCMT2(10), MAOA(2), MAOB(4), METTL2B(4), METTL6(1), PRMT2(5), PRMT3(3), PRMT5(6), PRMT6(2), PRMT7(3), PRMT8(4), PRPS2(1), UROC1(4), WBSCR22(2)	54699107	124	82	123	28	23	32	27	16	25	1	0.109	1.000	1.000
381	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(5), ALDOB(3), ALDOC(2), DLAT(2), DLD(1), ENO2(1), ENO3(2), FBP1(2), G6PC(2), GAPDH(1), GAPDHS(2), GCK(3), GOT1(2), GOT2(1), GPI(3), HK1(3), HK2(5), HK3(5), LDHA(3), LDHC(4), MDH1(1), PC(10), PCK1(5), PDHA1(2), PDHA2(4), PDHB(1), PDHX(3), PFKL(1), PFKM(8), PFKP(7), PGAM2(1), PGK1(6), PGK2(1), PKLR(5), TNFAIP1(1), TPI1(2)	60080758	110	82	108	25	17	29	21	26	17	0	0.0761	1.000	1.000
382	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(2), ALDH18A1(4), ARG1(3), ARG2(2), ASL(4), CKB(1), CKM(1), CKMT1A(1), CKMT1B(1), CKMT2(5), CPS1(12), GAMT(1), GATM(3), GLUD1(2), NAGS(1), OAT(2), OTC(3), PYCR1(1)	24762896	49	40	49	13	5	12	18	9	5	0	0.394	1.000	1.000
383	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(2), GTF2E1(2), GTF2E2(3), GTF2F1(1), GTF2F2(1), GTF2H1(2), GTF2H3(2), GTF2I(4), GTF2IRD1(1), TAF1(16), TAF13(1), TAF1L(19), TAF2(7), TAF4(3), TAF4B(6), TAF5(4), TAF5L(5), TAF6(3), TAF6L(2), TAF7(1), TAF7L(6), TAF9(2), TBPL2(2)	50872537	95	67	94	18	19	29	13	19	15	0	0.0871	1.000	1.000
384	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(9), ACO1(4), ACO2(5), CLYBL(3), CS(2), DLD(1), DLST(3), FH(3), IDH1(5), IDH3A(2), IDH3B(2), IDH3G(1), MDH1(1), OGDH(7), OGDHL(6), PC(10), PCK1(5), PCK2(4), SDHB(2), SDHD(1), SUCLA2(1), SUCLG2(1)	43162314	78	63	78	19	16	16	21	18	7	0	0.163	1.000	1.000
385	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	52	ACYP1(2), ADH1A(1), ADH1C(4), ADH4(1), ADH6(2), ADH7(3), ADHFE1(2), AKR1A1(1), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH3B2(4), ALDH9A1(1), ALDOA(5), ALDOB(3), ALDOC(2), BPGM(1), DLAT(2), DLD(1), ENO2(1), ENO3(2), FBP1(2), G6PC(2), GAPDH(1), GCK(3), GPI(3), HK1(3), HK2(5), HK3(5), LDHA(3), LDHC(4), PDHA1(2), PDHA2(4), PDHB(1), PFKM(8), PFKP(7), PGK1(6), PGM1(5), PGM3(2), PKLR(5), TPI1(2)	68827905	132	97	129	29	22	31	32	26	21	0	0.0624	1.000	1.000
386	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	52	ACYP1(2), ADH1A(1), ADH1C(4), ADH4(1), ADH6(2), ADH7(3), ADHFE1(2), AKR1A1(1), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH3B2(4), ALDH9A1(1), ALDOA(5), ALDOB(3), ALDOC(2), BPGM(1), DLAT(2), DLD(1), ENO2(1), ENO3(2), FBP1(2), G6PC(2), GAPDH(1), GCK(3), GPI(3), HK1(3), HK2(5), HK3(5), LDHA(3), LDHC(4), PDHA1(2), PDHA2(4), PDHB(1), PFKM(8), PFKP(7), PGK1(6), PGM1(5), PGM3(2), PKLR(5), TPI1(2)	68827905	132	97	129	29	22	31	32	26	21	0	0.0624	1.000	1.000
387	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	50	AKR1C3(1), ALOX12(7), ALOX12B(1), ALOX15(4), ALOX15B(5), ALOX5(3), CBR1(3), CYP2B6(5), CYP2C18(2), CYP2C19(6), CYP2C8(3), CYP2C9(3), CYP2E1(2), CYP2U1(1), CYP4A11(8), CYP4A22(2), CYP4F2(3), CYP4F3(3), DHRS4(2), EPHX2(4), GGT1(4), GPX2(1), GPX3(1), GPX4(1), GPX5(1), LTA4H(2), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PTGDS(4), PTGES2(2), PTGIS(4), PTGS1(5), PTGS2(5), TBXAS1(3)	55405602	120	89	120	28	16	32	30	24	18	0	0.0704	1.000	1.000
388	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(12), ARHGEF1(10), GNA12(2), GNA13(1), GNAQ(1), GNB1(2), MYLK(11), PLCB1(13), PPP1R12B(4), PRKCA(4), ROCK1(8)	29874062	68	47	68	16	10	10	15	13	20	0	0.407	1.000	1.000
389	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(5), CSF1R(3), DDX20(4), E2F1(5), E2F4(2), ETS1(3), ETS2(7), ETV3(4), FOS(1), HDAC2(2), HDAC5(6), HRAS(2), JUN(3), NCOR2(8), RBL1(6), SIN3A(10), SIN3B(7)	37458237	78	66	78	20	14	21	8	14	21	0	0.566	1.000	1.000
390	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(12), ACE2(4), AGT(3), AGTR1(4), AGTR2(2), ANPEP(8), CPA3(1), CTSA(3), CTSG(1), ENPEP(9), LNPEP(2), MAS1(2), MME(1), NLN(2), REN(1), THOP1(1)	30065638	56	37	56	15	8	15	7	16	10	0	0.452	1.000	1.000
391	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(5), ACTG1(8), ACTN1(6), ACTN2(10), ACTN3(7), ACTN4(7), AKT1(2), AKT2(5), AKT3(4), ARHGAP5(12), BAD(1), BCAR1(6), BIRC2(3), BIRC3(4), BRAF(5), CAPN2(8), CAV1(4), CCND1(1), CCND2(3), CCND3(5), COL11A1(8), COL11A2(5), COL1A1(8), COL1A2(10), COL2A1(4), COL3A1(7), COL4A1(9), COL4A2(9), COL4A4(9), COL4A6(10), COL5A1(13), COL5A2(8), COL5A3(11), COL6A1(3), COL6A2(4), COL6A3(15), COL6A6(14), COMP(5), CRK(1), CRKL(1), CTNNB1(2), DIAPH1(5), DOCK1(8), EGF(5), EGFR(5), ELK1(4), ERBB2(23), FARP2(10), FIGF(3), FLNA(20), FLNB(14), FLNC(21), FLT1(5), FN1(10), GSK3B(2), HGF(5), HRAS(2), IBSP(5), IGF1R(7), ILK(3), ITGA1(6), ITGA10(10), ITGA11(7), ITGA2(4), ITGA2B(3), ITGA3(1), ITGA4(6), ITGA5(4), ITGA6(4), ITGA7(6), ITGA8(10), ITGA9(7), ITGAV(7), ITGB1(5), ITGB3(4), ITGB4(8), ITGB5(3), ITGB6(6), ITGB7(5), ITGB8(4), JUN(3), KDR(8), LAMA1(18), LAMA2(15), LAMA3(15), LAMA4(9), LAMA5(11), LAMB1(12), LAMB2(9), LAMB3(7), LAMB4(15), LAMC1(8), LAMC2(6), LAMC3(4), MAP2K1(5), MAPK1(1), MAPK10(4), MAPK3(1), MAPK8(2), MAPK9(1), MET(10), MYL5(3), MYL7(1), MYL9(1), MYLK(11), MYLK2(5), MYLPF(1), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PAK7(4), PARVA(3), PARVG(3), PDGFB(2), PDGFRA(6), PDGFRB(7), PDPK1(2), PGF(5), PIK3CA(352), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R1(16), PIK3R2(4), PIK3R3(3), PIK3R5(5), PIP5K1C(5), PPP1CB(1), PPP1R12A(8), PRKCA(4), PRKCG(3), PTEN(36), PTK2(7), RAF1(4), RAP1A(2), RAP1B(1), RAPGEF1(5), RELN(26), RHOA(6), ROCK1(8), ROCK2(9), SHC1(2), SHC2(3), SHC3(1), SHC4(5), SOS1(5), SOS2(6), SPP1(2), SRC(1), THBS1(8), THBS2(2), THBS3(5), THBS4(4), TLN1(16), TLN2(14), TNC(10), TNN(10), TNR(11), TNXB(16), VAV1(6), VAV2(3), VAV3(7), VCL(6), VEGFA(1), VEGFC(2), VTN(3), VWF(11), ZYX(2)	521423756	1452	626	1129	321	210	395	218	399	223	7	4.30e-05	1.000	1.000
392	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	246	ACVR1B(8), ACVR1C(2), AKT1(2), AKT2(5), AKT3(4), ARRB1(1), ARRB2(1), ATF2(4), ATF4(3), BDNF(2), BRAF(5), CACNA1A(16), CACNA1B(14), CACNA1C(17), CACNA1D(18), CACNA1E(28), CACNA1F(17), CACNA1G(13), CACNA1H(11), CACNA1I(5), CACNA1S(8), CACNA2D1(7), CACNA2D2(7), CACNA2D3(9), CACNA2D4(5), CACNB1(3), CACNB2(3), CACNB3(4), CACNB4(2), CACNG1(1), CACNG2(1), CACNG3(3), CACNG4(2), CACNG5(2), CACNG6(1), CACNG7(3), CACNG8(1), CASP3(1), CD14(1), CDC25B(3), CHUK(8), CRK(1), CRKL(1), DAXX(2), DUSP1(1), DUSP10(9), DUSP16(6), DUSP2(1), DUSP4(1), DUSP6(1), DUSP7(3), DUSP9(2), EGF(5), EGFR(5), ELK1(4), ELK4(1), FAS(1), FASLG(2), FGF10(2), FGF11(1), FGF12(1), FGF13(4), FGF14(1), FGF16(2), FGF18(4), FGF20(2), FGF21(1), FGF23(3), FGF3(2), FGF6(2), FGF7(3), FGF8(2), FGF9(1), FGFR1(3), FGFR2(12), FGFR3(4), FGFR4(5), FLNA(20), FLNB(14), FLNC(21), FOS(1), GNA12(2), HRAS(2), IKBKB(6), IL1A(1), IL1R1(1), IL1R2(4), JUN(3), KRAS(6), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K4(32), MAP2K5(1), MAP2K6(1), MAP2K7(1), MAP3K1(79), MAP3K10(3), MAP3K12(7), MAP3K13(10), MAP3K2(3), MAP3K3(1), MAP3K4(8), MAP3K5(12), MAP3K6(3), MAP3K7(3), MAP3K8(4), MAP4K1(10), MAP4K2(2), MAP4K3(2), MAP4K4(13), MAPK1(1), MAPK10(4), MAPK13(1), MAPK14(2), MAPK3(1), MAPK7(4), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(8), MAPK9(1), MAPKAPK2(1), MAPKAPK3(2), MAPT(4), MAX(2), MEF2C(4), MKNK1(2), MKNK2(4), MOS(3), MRAS(2), MYC(1), NF1(28), NFATC2(4), NFATC4(8), NFKB1(5), NFKB2(5), NLK(1), NR4A1(3), NRAS(2), NTRK1(8), NTRK2(5), PAK1(4), PAK2(2), PDGFB(2), PDGFRA(6), PDGFRB(7), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PPM1A(2), PPM1B(3), PPP3CA(5), PPP3CB(3), PPP3CC(1), PPP3R1(1), PPP5C(6), PRKACA(4), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(3), PRKX(5), PTPN5(5), PTPN7(5), PTPRR(4), RAF1(4), RAP1A(2), RAP1B(1), RAPGEF2(8), RASA1(2), RASA2(4), RASGRF1(12), RASGRF2(5), RASGRP2(6), RASGRP3(2), RASGRP4(5), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), RPS6KA4(2), RPS6KA5(4), RPS6KA6(6), SOS1(5), SOS2(6), SRF(1), STK3(2), STK4(3), TAOK1(5), TAOK2(8), TAOK3(5), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TGFBR2(4), TNFRSF1A(4), TP53(298), TRAF2(1), TRAF6(4), ZAK(6)	411334547	1297	620	1132	269	229	237	199	251	361	20	1.43e-05	1.000	1.000
393	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	199	ABI2(3), ACTN1(6), ACTN2(10), ACTN3(7), ACTN4(7), APC(23), ARAF(6), ARHGEF1(10), ARHGEF12(11), ARHGEF4(7), ARHGEF6(6), ARHGEF7(8), ARPC1A(3), ARPC1B(2), ARPC2(5), ARPC5(1), ARPC5L(3), BAIAP2(2), BCAR1(6), BDKRB1(4), BDKRB2(4), BRAF(5), CD14(1), CFL1(1), CFL2(1), CHRM1(4), CHRM2(6), CHRM3(3), CHRM4(1), CRK(1), CRKL(1), CYFIP1(5), CYFIP2(13), DIAPH1(5), DIAPH2(9), DIAPH3(6), DOCK1(8), EGF(5), EGFR(5), EZR(1), F2(2), F2R(4), FGD1(1), FGD3(4), FGF10(2), FGF11(1), FGF12(1), FGF13(4), FGF14(1), FGF16(2), FGF18(4), FGF20(2), FGF21(1), FGF23(3), FGF3(2), FGF6(2), FGF7(3), FGF8(2), FGF9(1), FGFR1(3), FGFR2(12), FGFR3(4), FGFR4(5), FN1(10), GIT1(3), GNA12(2), GNA13(1), GSN(2), HRAS(2), IQGAP1(7), IQGAP2(8), IQGAP3(9), ITGA1(6), ITGA10(10), ITGA11(7), ITGA2(4), ITGA2B(3), ITGA3(1), ITGA4(6), ITGA5(4), ITGA6(4), ITGA7(6), ITGA8(10), ITGA9(7), ITGAD(3), ITGAE(2), ITGAL(5), ITGAM(6), ITGAV(7), ITGAX(10), ITGB1(5), ITGB2(8), ITGB3(4), ITGB4(8), ITGB5(3), ITGB6(6), ITGB7(5), ITGB8(4), KRAS(6), LIMK1(8), LIMK2(4), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), MOS(3), MRAS(2), MSN(4), MYH10(14), MYH14(13), MYH9(22), MYL5(3), MYL7(1), MYL9(1), MYLK(11), MYLK2(5), MYLPF(1), NCKAP1(9), NCKAP1L(8), NRAS(2), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PAK7(4), PDGFB(2), PDGFRA(6), PDGFRB(7), PIK3CA(352), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R1(16), PIK3R2(4), PIK3R3(3), PIK3R5(5), PIP4K2A(2), PIP4K2C(6), PIP5K1A(6), PIP5K1B(2), PIP5K1C(5), PPP1CB(1), PPP1R12A(8), PPP1R12B(4), PTK2(7), RAF1(4), RDX(3), RHOA(6), ROCK1(8), ROCK2(9), SCIN(5), SLC9A1(4), SOS1(5), SOS2(6), SSH1(7), SSH2(5), SSH3(4), TIAM1(7), TIAM2(11), VAV1(6), VAV2(3), VAV3(7), VCL(6), WAS(6), WASF1(6), WASF2(3), WASL(4)	396468198	1198	574	881	284	172	347	157	356	162	4	0.00469	1.000	1.000
394	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	141	APC(23), AXIN1(5), AXIN2(5), BTRC(4), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CCND1(1), CCND2(3), CCND3(5), CER1(2), CHD8(17), CREBBP(15), CSNK1A1(4), CSNK1A1L(4), CSNK1E(4), CSNK2A1(3), CSNK2A2(1), CTBP1(1), CTBP2(1), CTNNB1(2), CUL1(2), DAAM1(8), DAAM2(5), DKK2(1), DKK4(3), DVL1(2), DVL3(1), EP300(13), FZD1(3), FZD10(4), FZD2(4), FZD3(5), FZD4(1), FZD5(1), FZD6(4), FZD7(3), FZD8(1), FZD9(3), GSK3B(2), JUN(3), LRP5(4), LRP6(7), MAP3K7(3), MAPK10(4), MAPK8(2), MAPK9(1), MYC(1), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), NKD1(1), NKD2(2), NLK(1), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PORCN(4), PPARD(2), PPP2CA(3), PPP2CB(2), PPP2R1A(2), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PPP3CA(5), PPP3CB(3), PPP3CC(1), PPP3R1(1), PRICKLE1(2), PRICKLE2(6), PRKACA(4), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(3), PRKX(5), PSEN1(2), RHOA(6), ROCK1(8), ROCK2(9), RUVBL1(2), SENP2(1), SFRP1(3), SFRP2(2), SFRP4(2), SIAH1(3), SKP1(1), SMAD2(7), SMAD3(4), SMAD4(7), TBL1X(5), TBL1XR1(10), TCF7(4), TCF7L1(2), TCF7L2(5), TP53(298), VANGL1(2), VANGL2(8), WIF1(3), WNT10B(1), WNT11(1), WNT16(2), WNT2(1), WNT2B(4), WNT3(1), WNT3A(1), WNT4(1), WNT5B(4), WNT6(1), WNT7A(6), WNT7B(1), WNT8B(2), WNT9A(1)	220895478	756	451	613	147	145	133	106	157	209	6	0.000180	1.000	1.000
395	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(6), ADCY7(11), ADCY8(6), ADCY9(14), ADORA2A(4), ADRA1A(6), ADRA1B(1), ADRB2(2), ADRB3(1), AGTR1(4), ATP2A1(11), ATP2A2(5), ATP2A3(2), ATP2B1(14), ATP2B2(10), ATP2B3(10), ATP2B4(11), AVPR1B(5), BDKRB1(4), BDKRB2(4), BST1(3), CACNA1A(16), CACNA1B(14), CACNA1C(17), CACNA1D(18), CACNA1E(28), CACNA1F(17), CACNA1G(13), CACNA1H(11), CACNA1I(5), CACNA1S(8), CALM2(2), CALML6(1), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CAMK4(5), CCKAR(3), CCKBR(2), CD38(3), CHRM1(4), CHRM2(6), CHRM3(3), CHRNA7(1), CYSLTR1(5), CYSLTR2(1), DRD1(1), EDNRA(3), EDNRB(2), EGFR(5), ERBB2(23), ERBB3(19), ERBB4(14), F2R(4), GNA11(4), GNA14(1), GNAQ(1), GNAS(11), GRIN1(3), GRIN2A(16), GRIN2C(5), GRIN2D(5), GRM1(9), GRM5(4), GRPR(3), HRH1(4), HRH2(4), HTR2A(5), HTR2C(6), HTR5A(4), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), LHCGR(10), MYLK(11), MYLK2(5), NOS1(13), NOS3(3), OXTR(1), P2RX2(3), P2RX3(1), P2RX4(2), P2RX5(4), P2RX7(3), PDE1A(5), PDE1B(5), PDE1C(5), PDGFRA(6), PDGFRB(7), PHKA1(8), PHKA2(13), PHKB(4), PHKG2(1), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PLCD1(3), PLCD3(2), PLCD4(6), PLCE1(15), PLCG1(8), PLCG2(8), PLCZ1(11), PLN(1), PPID(3), PPP3CA(5), PPP3CB(3), PPP3CC(1), PPP3R1(1), PRKACA(4), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(3), PRKX(5), PTAFR(1), PTGER3(4), PTGFR(1), PTK2B(7), RYR1(29), RYR2(53), RYR3(43), SLC25A4(3), SLC25A5(2), SLC25A6(2), SLC8A1(11), SLC8A2(3), SLC8A3(4), SPHK1(1), SPHK2(3), TACR1(2), TACR2(4), TACR3(2), TNNC2(2), TRPC1(9), VDAC1(1), VDAC2(3), VDAC3(1)	388791648	981	431	965	302	220	229	173	228	129	2	0.241	1.000	1.000
396	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	129	ACTB(5), ACTG1(8), ACTN1(6), ACTN2(10), ACTN3(7), ACTN4(7), AKT1(2), AKT2(5), AKT3(4), AMOTL1(6), ASH1L(19), CASK(9), CDK4(1), CGN(7), CLDN1(1), CLDN10(2), CLDN11(1), CLDN14(1), CLDN15(1), CLDN16(2), CLDN17(2), CLDN18(2), CLDN19(2), CLDN2(1), CLDN22(2), CLDN4(1), CLDN6(6), CRB3(1), CSNK2A1(3), CSNK2A2(1), CTNNA1(7), CTNNA2(14), CTNNA3(6), CTNNB1(2), CTTN(2), EPB41(5), EPB41L1(7), EPB41L2(8), EPB41L3(11), EXOC3(6), EXOC4(9), F11R(4), GNAI1(2), GNAI2(2), GNAI3(1), HCLS1(2), HRAS(2), IGSF5(3), INADL(12), JAM2(1), KRAS(6), LLGL1(5), LLGL2(3), MAGI1(17), MAGI2(9), MAGI3(7), MLLT4(20), MPDZ(13), MPP5(3), MRAS(2), MYH1(13), MYH10(14), MYH11(13), MYH13(11), MYH14(13), MYH15(16), MYH2(9), MYH3(5), MYH4(8), MYH6(11), MYH7(20), MYH7B(11), MYH8(15), MYH9(22), MYL5(3), MYL7(1), MYL9(1), MYLPF(1), NRAS(2), OCLN(3), PARD3(8), PARD6A(1), PARD6B(2), PPM1J(2), PPP2CA(3), PPP2CB(2), PPP2R1A(2), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PPP2R3A(4), PPP2R3B(2), PPP2R4(5), PRKCA(4), PRKCD(5), PRKCE(8), PRKCG(3), PRKCH(3), PRKCI(1), PRKCQ(9), PRKCZ(2), PTEN(36), RAB13(3), RAB3B(1), RHOA(6), SPTAN1(13), SRC(1), SYMPK(8), TJAP1(3), TJP1(8), TJP2(6), TJP3(4), VAPA(2), YES1(2), ZAK(6)	278354810	678	349	662	182	126	167	107	135	138	5	0.563	1.000	1.000
397	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	135	ACTB(5), ACTG1(8), COL11A1(8), COL11A2(5), COL17A1(9), COL1A1(8), COL1A2(10), COL2A1(4), COL3A1(7), COL4A1(9), COL4A2(9), COL4A4(9), COL4A6(10), COL5A1(13), COL5A2(8), COL5A3(11), COL6A1(3), COL6A2(4), COL6A3(15), COL6A6(14), COMP(5), DSC1(3), DSC2(12), DSC3(3), DSG1(4), DSG2(4), DSG3(8), DSG4(6), FN1(10), GJA1(4), GJA10(3), GJA4(1), GJA5(4), GJA8(2), GJA9(1), GJB1(1), GJB2(1), GJB3(3), GJB4(1), GJB5(2), GJB6(1), GJB7(1), GJC1(1), GJD2(2), GJD4(2), IBSP(5), ITGA6(4), ITGB4(8), KRT1(6), KRT10(1), KRT12(1), KRT13(2), KRT14(4), KRT15(1), KRT16(1), KRT17(2), KRT18(3), KRT19(7), KRT2(5), KRT20(2), KRT23(3), KRT24(2), KRT25(5), KRT27(1), KRT28(5), KRT3(4), KRT31(2), KRT32(4), KRT33A(1), KRT33B(1), KRT34(3), KRT35(2), KRT36(2), KRT37(1), KRT38(1), KRT39(1), KRT4(3), KRT40(1), KRT5(4), KRT6A(1), KRT6B(3), KRT6C(1), KRT7(1), KRT71(1), KRT72(3), KRT73(5), KRT74(1), KRT75(4), KRT76(2), KRT78(3), KRT79(2), KRT8(2), KRT81(3), KRT82(4), KRT83(4), KRT84(3), KRT85(3), KRT86(4), KRT9(3), LAMA1(18), LAMA2(15), LAMA3(15), LAMA4(9), LAMA5(11), LAMB1(12), LAMB2(9), LAMB3(7), LAMB4(15), LAMC1(8), LAMC2(6), LAMC3(4), LMNA(4), LMNB1(2), LMNB2(3), NES(14), RELN(26), SPP1(2), THBS1(8), THBS2(2), THBS3(5), THBS4(4), TNC(10), TNN(10), TNR(11), TNXB(16), VIM(2), VTN(3), VWF(11)	347778600	667	347	660	224	134	158	149	121	103	2	0.963	1.000	1.000
398	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(6), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), ADRA1A(6), ADRA1B(1), ADRB2(2), ADRB3(1), ANXA6(5), ARRB1(1), ARRB2(1), ATP1A4(13), ATP1B1(3), ATP1B3(1), ATP2A2(5), ATP2A3(2), ATP2B1(14), ATP2B2(10), ATP2B3(10), CACNA1A(16), CACNA1B(14), CACNA1C(17), CACNA1D(18), CACNA1E(28), CACNA1S(8), CACNB1(3), CACNB3(4), CALM2(2), CALR(1), CAMK1(1), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CAMK4(5), CASQ1(2), CASQ2(6), CHRM1(4), CHRM2(6), CHRM3(3), CHRM4(1), GJA1(4), GJA4(1), GJA5(4), GJB1(1), GJB2(1), GJB3(3), GJB4(1), GJB5(2), GJB6(1), GNA11(4), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNAZ(3), GNB1(2), GNB2(1), GNB3(3), GNB5(2), GRK4(1), GRK5(2), GRK6(3), ITPR1(15), ITPR2(18), ITPR3(14), KCNB1(7), KCNJ3(2), KCNJ5(1), MIB1(7), NME7(4), PEA15(1), PKIA(1), PKIG(2), PLCB3(2), PLN(1), PRKACA(4), PRKACB(1), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKCA(4), PRKCD(5), PRKCE(8), PRKCG(3), PRKCH(3), PRKCQ(9), PRKCZ(2), PRKD1(6), RGS1(2), RGS10(1), RGS11(2), RGS14(5), RGS16(3), RGS17(3), RGS20(4), RGS3(9), RGS4(4), RGS5(2), RGS6(4), RGS7(10), RGS9(6), RYR1(29), RYR2(53), RYR3(43), SFN(1), SLC8A1(11), SLC8A3(4), USP5(7), YWHAB(2)	274079204	670	344	667	224	160	151	125	141	91	2	0.760	1.000	1.000
399	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	124	ALCAM(6), CADM1(3), CADM3(2), CD2(4), CD22(5), CD226(2), CD274(2), CD276(1), CD28(2), CD34(3), CD4(4), CD40(2), CD40LG(1), CD58(2), CD6(1), CD86(6), CD8A(3), CD8B(3), CD99(4), CDH1(108), CDH15(2), CDH2(2), CDH3(1), CDH4(6), CDH5(1), CLDN1(1), CLDN10(2), CLDN11(1), CLDN14(1), CLDN15(1), CLDN16(2), CLDN17(2), CLDN18(2), CLDN19(2), CLDN2(1), CLDN22(2), CLDN4(1), CLDN6(6), CNTN1(11), CNTN2(7), CNTNAP1(11), CNTNAP2(11), CTLA4(1), ESAM(4), F11R(4), GLG1(6), HLA-A(3), HLA-B(6), HLA-C(9), HLA-DMA(1), HLA-DMB(3), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(3), HLA-DRB1(10), HLA-DRB5(5), HLA-F(5), HLA-G(1), ICAM1(2), ICAM2(1), ICAM3(3), ICOS(3), ICOSLG(6), ITGA4(6), ITGA6(4), ITGA8(10), ITGA9(7), ITGAL(5), ITGAM(6), ITGAV(7), ITGB1(5), ITGB2(8), ITGB7(5), ITGB8(4), JAM2(1), L1CAM(10), MADCAM1(1), MAG(3), MPZ(1), MPZL1(3), NCAM1(6), NCAM2(4), NEGR1(2), NEO1(6), NFASC(11), NLGN1(7), NLGN2(7), NLGN3(11), NRCAM(13), NRXN1(12), NRXN2(12), NRXN3(13), OCLN(3), PDCD1(2), PTPRC(8), PTPRF(11), PTPRM(8), PVR(3), PVRL1(3), PVRL2(6), PVRL3(5), SDC1(3), SDC2(2), SDC3(2), SDC4(2), SELE(2), SELL(6), SELP(11), SELPLG(2), SIGLEC1(7), SPN(2), VCAM1(7), VCAN(22)	201275712	626	340	601	154	89	139	106	103	187	2	0.0729	1.000	1.000
400	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	233	ADCYAP1R1(4), ADORA1(3), ADORA2A(4), ADORA3(1), ADRA1A(6), ADRA1B(1), ADRA2B(4), ADRA2C(2), ADRB2(2), ADRB3(1), AGTR1(4), AGTR2(2), AVPR1B(5), AVPR2(3), BDKRB1(4), BDKRB2(4), BRS3(4), C3AR1(3), C5AR1(3), CALCR(2), CALCRL(3), CCKAR(3), CCKBR(2), CHRM1(4), CHRM2(6), CHRM3(3), CHRM4(1), CNR1(1), CNR2(1), CRHR1(3), CRHR2(1), CTSG(1), CYSLTR1(5), CYSLTR2(1), DRD1(1), DRD2(3), DRD3(1), DRD5(4), EDNRA(3), EDNRB(2), F2(2), F2R(4), F2RL1(1), F2RL2(2), FPR1(3), FSHR(9), GABBR1(3), GABBR2(4), GABRA1(4), GABRA2(3), GABRA3(6), GABRA4(7), GABRA5(4), GABRA6(6), GABRB1(3), GABRB2(5), GABRB3(1), GABRD(1), GABRE(2), GABRG1(7), GABRG2(3), GABRG3(4), GABRP(1), GABRQ(5), GABRR1(2), GALR1(1), GALR2(2), GALR3(1), GH2(3), GHR(5), GHRHR(5), GHSR(2), GIPR(1), GLP1R(2), GLP2R(4), GLRA2(2), GLRA3(2), GLRB(1), GPR156(4), GPR35(1), GPR50(4), GPR63(3), GPR83(5), GRIA1(9), GRIA2(4), GRIA3(16), GRIA4(8), GRID1(12), GRID2(11), GRIK1(11), GRIK2(12), GRIK3(6), GRIK4(3), GRIK5(5), GRIN1(3), GRIN2A(16), GRIN2B(11), GRIN2C(5), GRIN2D(5), GRIN3A(10), GRIN3B(3), GRM1(9), GRM2(3), GRM3(10), GRM4(3), GRM5(4), GRM6(2), GRM7(4), GRM8(5), GRPR(3), GZMA(2), HCRTR1(2), HCRTR2(2), HRH1(4), HRH2(4), HRH3(2), HRH4(2), HTR1A(4), HTR1B(3), HTR1D(4), HTR1E(4), HTR1F(4), HTR2A(5), HTR2C(6), HTR5A(4), LEP(1), LEPR(7), LHCGR(10), MAS1(2), MC2R(2), MC3R(3), MC4R(2), MCHR1(1), MCHR2(3), MLNR(1), NMBR(3), NMUR1(3), NMUR2(3), NPBWR1(3), NPFFR2(7), NPY1R(5), NPY2R(3), NR3C1(3), NTSR2(2), OPRD1(3), OPRK1(2), OPRL1(3), OPRM1(5), OXTR(1), P2RX2(3), P2RX3(1), P2RX4(2), P2RX5(4), P2RX7(3), P2RY1(4), P2RY10(7), P2RY13(4), P2RY2(1), P2RY4(2), P2RY6(1), P2RY8(1), PARD3(8), PPYR1(4), PRLHR(2), PRLR(4), PRSS3(3), PTAFR(1), PTGDR(2), PTGER2(2), PTGER3(4), PTGER4(1), PTGFR(1), PTH2R(2), RXFP1(4), RXFP2(3), SSTR2(1), SSTR3(2), SSTR4(1), SSTR5(1), TAAR1(3), TAAR2(4), TAAR5(4), TAAR6(2), TAAR8(1), TAAR9(2), TACR1(2), TACR2(4), TACR3(2), THRA(3), THRB(2), TRPV1(1), TSHR(7), VIPR1(2), VIPR2(4)	305056939	696	335	694	237	152	168	138	159	76	3	0.404	1.000	1.000
401	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(7), CD36(5), CD44(4), CD47(2), COL11A1(8), COL11A2(5), COL1A1(8), COL1A2(10), COL2A1(4), COL3A1(7), COL4A1(9), COL4A2(9), COL4A4(9), COL4A6(10), COL5A1(13), COL5A2(8), COL5A3(11), COL6A1(3), COL6A2(4), COL6A3(15), COL6A6(14), DAG1(2), FN1(10), FNDC1(15), FNDC3A(5), GP5(3), GP6(4), HMMR(3), HSPG2(15), IBSP(5), ITGA1(6), ITGA10(10), ITGA11(7), ITGA2(4), ITGA2B(3), ITGA3(1), ITGA4(6), ITGA5(4), ITGA6(4), ITGA7(6), ITGA8(10), ITGA9(7), ITGAV(7), ITGB1(5), ITGB3(4), ITGB4(8), ITGB5(3), ITGB6(6), ITGB7(5), ITGB8(4), LAMA1(18), LAMA2(15), LAMA3(15), LAMA4(9), LAMA5(11), LAMB1(12), LAMB2(9), LAMB3(7), LAMB4(15), LAMC1(8), LAMC2(6), LAMC3(4), RELN(26), SDC1(3), SDC2(2), SDC3(2), SDC4(2), SPP1(2), SV2A(4), SV2B(4), SV2C(1), THBS1(8), THBS2(2), THBS3(5), THBS4(4), TNC(10), TNN(10), TNR(11), TNXB(16), VTN(3), VWF(11)	312799380	592	314	584	199	111	141	126	113	98	3	0.968	1.000	1.000
402	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	136	ACTA1(3), ACTA2(3), ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(6), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), ADM(1), ARRB1(1), ARRB2(1), ATF1(3), ATF2(4), ATF3(2), ATF4(3), ATF5(1), ATP2A2(5), ATP2A3(2), CACNB3(4), CALCA(2), CALM2(2), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CNN1(4), CNN2(1), CORIN(6), CREB3(1), CRHR1(3), DGKZ(1), ETS2(7), FOS(1), GABPA(1), GABPB2(2), GBA2(4), GJA1(4), GNAQ(1), GNB1(2), GNB2(1), GNB3(3), GNB5(2), GRK4(1), GRK5(2), GRK6(3), GSTO1(1), GUCY1A3(2), IGFBP2(1), IGFBP3(1), IGFBP4(1), IGFBP6(1), IL6(2), ITPR1(15), ITPR2(18), ITPR3(14), JUN(3), MIB1(7), MYLK2(5), NFKB1(5), NOS1(13), NOS3(3), OXTR(1), PDE4B(12), PDE4D(8), PKIA(1), PKIG(2), PLCB3(2), PLCD1(3), PLCG1(8), PLCG2(8), PRKACA(4), PRKACB(1), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKCA(4), PRKCD(5), PRKCE(8), PRKCH(3), PRKCQ(9), PRKCZ(2), PRKD1(6), RAMP3(1), RGS1(2), RGS10(1), RGS11(2), RGS14(5), RGS16(3), RGS17(3), RGS20(4), RGS3(9), RGS4(4), RGS5(2), RGS6(4), RGS7(10), RGS9(6), RYR1(29), RYR2(53), RYR3(43), SFN(1), SLC8A1(11), SP1(6), TNXB(16), USP5(7), YWHAB(2)	244696247	576	311	572	192	137	135	101	116	84	3	0.861	1.000	1.000
403	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(6), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), ATF4(3), CACNA1C(17), CACNA1D(18), CACNA1F(17), CACNA1S(8), CALM2(2), CALML6(1), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), EGFR(5), ELK1(4), GNA11(4), GNAQ(1), GNAS(11), HRAS(2), ITPR1(15), ITPR2(18), ITPR3(14), JUN(3), KRAS(6), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K4(32), MAP2K6(1), MAP2K7(1), MAP3K1(79), MAP3K2(3), MAP3K3(1), MAP3K4(8), MAPK1(1), MAPK10(4), MAPK13(1), MAPK14(2), MAPK3(1), MAPK7(4), MAPK8(2), MAPK9(1), MMP14(4), MMP2(4), NRAS(2), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PLD1(7), PLD2(2), PRKACA(4), PRKACB(1), PRKACG(3), PRKCA(4), PRKCD(5), PRKX(5), PTK2B(7), RAF1(4), SOS1(5), SOS2(6), SRC(1)	184509309	496	309	477	127	86	103	73	93	124	17	0.450	1.000	1.000
404	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACTB(5), ACTG1(8), ACTN1(6), ACTN2(10), ACTN3(7), ACTN4(7), ACVR1B(8), ACVR1C(2), BAIAP2(2), CDH1(108), CREBBP(15), CSNK2A1(3), CSNK2A2(1), CTNNA1(7), CTNNA2(14), CTNNA3(6), CTNNB1(2), CTNND1(6), EGFR(5), EP300(13), ERBB2(23), FARP2(10), FER(5), FGFR1(3), IGF1R(7), INSR(11), IQGAP1(7), LMO7(6), MAP3K7(3), MAPK1(1), MAPK3(1), MET(10), MLLT4(20), NLK(1), PARD3(8), PTPN6(2), PTPRB(12), PTPRF(11), PTPRJ(7), PTPRM(8), PVRL1(3), PVRL2(6), PVRL3(5), PVRL4(2), RHOA(6), SMAD2(7), SMAD3(4), SMAD4(7), SNAI1(2), SORBS1(7), SRC(1), SSX2IP(4), TCF7(4), TCF7L1(2), TCF7L2(5), TGFBR1(4), TGFBR2(4), TJP1(8), VCL(6), WAS(6), WASF1(6), WASF2(3), WASF3(5), WASL(4), YES1(2)	172626804	504	308	471	109	79	118	63	75	169	0	0.0754	1.000	1.000
405	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	126	ABL1(7), ABLIM1(4), ABLIM2(3), ABLIM3(6), ARHGEF12(11), CDK5(2), CFL1(1), CFL2(1), CXCR4(3), DCC(15), DPYSL2(2), DPYSL5(4), EFNA1(2), EFNA3(3), EFNA4(2), EFNA5(1), EFNB1(1), EFNB2(2), EFNB3(3), EPHA1(8), EPHA2(3), EPHA3(6), EPHA4(5), EPHA5(7), EPHA6(7), EPHA7(8), EPHA8(2), EPHB1(12), EPHB2(5), EPHB3(5), EPHB4(4), EPHB6(5), FES(3), GNAI1(2), GNAI2(2), GNAI3(1), GSK3B(2), HRAS(2), ITGB1(5), KRAS(6), L1CAM(10), LIMK1(8), LIMK2(4), LRRC4C(4), MAPK1(1), MAPK3(1), MET(10), NCK1(2), NCK2(1), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), NGEF(3), NRAS(2), NRP1(7), NTN1(3), NTN4(1), NTNG1(3), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PAK7(4), PLXNA1(12), PLXNA2(12), PLXNA3(9), PLXNB1(4), PLXNB2(9), PLXNB3(9), PLXNC1(6), PPP3CA(5), PPP3CB(3), PPP3CC(1), PPP3R1(1), PTK2(7), RASA1(2), RGS3(9), RHOA(6), RND1(2), ROBO1(13), ROBO2(11), ROBO3(6), ROCK1(8), ROCK2(9), SEMA3A(5), SEMA3C(7), SEMA3D(4), SEMA3E(2), SEMA3F(2), SEMA3G(2), SEMA4A(4), SEMA4B(2), SEMA4C(2), SEMA4D(8), SEMA4F(9), SEMA4G(6), SEMA5A(12), SEMA5B(6), SEMA6A(12), SEMA6C(5), SEMA6D(5), SEMA7A(2), SLIT1(2), SLIT2(11), SLIT3(5), SRGAP1(10), SRGAP2(12), SRGAP3(4), UNC5A(2), UNC5B(5), UNC5C(3), UNC5D(14)	271932410	596	305	588	179	113	150	127	109	97	0	0.559	1.000	1.000
406	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	249	ACVR1B(8), ACVR2A(8), ACVR2B(1), AMHR2(3), BMP2(3), BMPR1A(1), BMPR1B(6), BMPR2(8), CCL11(1), CCL13(4), CCL14(1), CCL15(1), CCL19(1), CCL2(1), CCL20(1), CCL21(1), CCL23(1), CCL26(1), CCL28(1), CCR1(3), CCR2(7), CCR3(2), CCR4(1), CCR5(1), CCR6(1), CCR7(4), CCR8(1), CCR9(1), CD40(2), CD40LG(1), CD70(1), CLCF1(1), CNTFR(2), CRLF2(1), CSF1(5), CSF1R(3), CSF2RA(3), CSF2RB(4), CSF3(2), CSF3R(6), CX3CL1(2), CX3CR1(3), CXCL10(1), CXCL2(1), CXCL6(3), CXCR3(6), CXCR4(3), CXCR6(1), EDA(2), EDA2R(3), EDAR(4), EGF(5), EGFR(5), EPO(1), EPOR(4), FAS(1), FASLG(2), FLT1(5), FLT3(4), FLT3LG(1), FLT4(3), GDF5(2), GH2(3), GHR(5), HGF(5), IFNA1(1), IFNA10(3), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(3), IFNA2(3), IFNA21(4), IFNA4(2), IFNA6(1), IFNA7(2), IFNA8(2), IFNAR1(2), IFNAR2(1), IFNG(2), IFNGR1(2), IFNK(2), IL10RA(1), IL10RB(3), IL11(1), IL11RA(5), IL12B(2), IL12RB1(7), IL12RB2(4), IL13RA1(1), IL15(3), IL17A(1), IL17B(2), IL17RA(2), IL17RB(3), IL18(2), IL18R1(4), IL18RAP(1), IL19(1), IL1A(1), IL1R1(1), IL1R2(4), IL1RAP(10), IL20(1), IL20RA(1), IL21(2), IL21R(2), IL22(2), IL22RA1(4), IL22RA2(3), IL23A(2), IL23R(4), IL24(3), IL25(2), IL28A(1), IL28B(1), IL28RA(2), IL29(2), IL2RA(2), IL2RB(3), IL2RG(2), IL3(1), IL3RA(3), IL4(1), IL4R(6), IL5RA(4), IL6(2), IL6R(5), IL6ST(9), IL7(1), IL7R(4), IL8(1), IL9R(2), INHBA(4), INHBB(1), INHBC(1), INHBE(3), KDR(8), KIT(8), KITLG(3), LEP(1), LEPR(7), LIF(2), LIFR(9), LTA(2), LTBR(1), MET(10), MPL(2), NGFR(1), OSM(1), OSMR(5), PDGFB(2), PDGFRA(6), PDGFRB(7), PF4(1), PLEKHO2(1), PPBP(1), PRLR(4), RELT(1), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TGFBR2(4), TNFRSF10A(1), TNFRSF10B(1), TNFRSF10D(1), TNFRSF11A(2), TNFRSF11B(3), TNFRSF13B(2), TNFRSF19(2), TNFRSF1A(4), TNFRSF1B(2), TNFRSF21(2), TNFRSF25(2), TNFRSF6B(1), TNFRSF8(4), TNFRSF9(2), TNFSF13(1), TNFSF13B(1), TNFSF14(1), TNFSF15(2), TNFSF18(1), TNFSF4(3), TNFSF8(1), TNFSF9(1), TPO(8), TSLP(1), VEGFA(1), VEGFC(2), XCL1(2), XCR1(3)	251668965	515	283	510	132	77	131	102	108	95	2	0.0777	1.000	1.000
407	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(3), ACTA2(3), ACTN2(10), ACTN3(7), ACTN4(7), DMD(49), FAM48A(4), MYBPC1(4), MYBPC2(11), MYBPC3(3), MYH3(5), MYH6(11), MYH7(20), MYH8(15), MYL1(1), MYL9(1), MYOM1(7), NEB(42), TMOD1(1), TNNC2(2), TNNI3(4), TNNT1(2), TNNT3(3), TPM1(4), TPM2(2), TPM3(3), TPM4(1), TTN(278), VIM(2)	205997026	505	281	502	136	82	169	75	111	63	5	0.597	1.000	1.000
408	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	56	ASH1L(19), ASH2L(4), CARM1(5), CTCFL(5), DOT1L(10), EED(4), EHMT1(9), EHMT2(6), EZH1(3), EZH2(3), FBXO11(5), HCFC1(19), HSF4(1), JMJD6(2), KDM6A(17), MEN1(4), MLL(20), MLL2(25), MLL3(78), MLL4(14), MLL5(11), NSD1(13), OGT(5), PAXIP1(6), PPP1CB(1), PRDM2(8), PRDM6(1), PRDM7(2), PRDM9(6), PRMT5(6), PRMT6(2), PRMT7(3), PRMT8(4), RBBP5(3), SATB1(10), SETD1A(4), SETD1B(9), SETD2(19), SETD7(5), SETD8(4), SETDB1(11), SETDB2(2), SETMAR(2), SMYD3(5), STK38(4), SUV39H1(2), SUV39H2(1), SUV420H1(8), SUV420H2(2), SUZ12(7), WHSC1(7), WHSC1L1(5)	174340817	431	262	424	80	48	105	67	73	132	6	0.0636	1.000	1.000
409	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	140	ADA(2), ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(6), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), ADK(2), ADSL(3), ADSS(3), ADSSL1(1), AK1(1), AK2(1), AK5(4), AK7(4), ALLC(4), AMPD1(9), AMPD2(2), AMPD3(7), ATIC(3), CANT1(2), DCK(1), DGUOK(4), ENPP1(7), ENPP3(6), ENTPD1(4), ENTPD2(3), ENTPD3(1), ENTPD4(4), ENTPD5(7), ENTPD6(4), ENTPD8(1), FHIT(2), GART(3), GDA(2), GMPR2(2), GMPS(5), GUCY1A2(6), GUCY1A3(2), GUCY1B3(2), GUCY2C(9), GUCY2D(4), GUCY2F(7), GUK1(1), IMPDH1(2), IMPDH2(2), ITPA(1), NME6(1), NME7(4), NPR1(5), NPR2(9), NT5C1A(2), NT5C1B(6), NT5C2(3), NT5C3(4), NT5E(6), NUDT2(1), NUDT5(2), NUDT9(2), PAICS(3), PAPSS1(2), PAPSS2(2), PDE10A(8), PDE11A(5), PDE1A(5), PDE1C(5), PDE2A(4), PDE3B(4), PDE4A(1), PDE4B(12), PDE4C(5), PDE4D(8), PDE5A(7), PDE7B(1), PDE8A(1), PDE8B(1), PDE9A(5), PFAS(6), PKLR(5), PNPT1(5), POLA1(15), POLA2(6), POLD1(5), POLD2(1), POLE(10), POLE2(2), POLE3(1), POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2D(1), POLR2F(5), POLR2G(1), POLR2H(1), POLR2J(1), POLR3A(5), POLR3B(2), POLR3GL(3), POLR3H(1), POLR3K(1), PPAT(5), PRIM1(1), PRPS2(1), PRUNE(4), RFC5(1), RRM1(4), RRM2(1), RRM2B(1), XDH(9)	232866942	462	250	457	146	89	129	92	93	58	1	0.816	1.000	1.000
410	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	90	ACTB(5), BAD(1), CABIN1(8), CALM2(2), CAMK2B(3), CAMK4(5), CD3E(3), CD3G(3), CD69(2), CDKN1A(1), CNR1(1), CREBBP(15), CSNK2A1(3), CTLA4(1), EGR2(3), EGR3(4), EP300(13), FCER1A(4), FCGR3A(4), FOS(1), GATA3(100), GATA4(2), GSK3A(5), GSK3B(2), HRAS(2), ICOS(3), IFNA1(1), IFNG(2), IL2RA(2), IL3(1), IL4(1), IL6(2), IL8(1), ITK(7), KPNA5(5), MAP2K7(1), MAPK14(2), MAPK8(2), MAPK9(1), MEF2A(6), MEF2D(3), MYF5(4), NCK2(1), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), NFKB2(5), NFKBIB(2), NFKBIE(2), NUP214(12), OPRD1(3), P2RX7(3), PAK1(4), PPP3CB(3), PPP3CC(1), PPP3R1(1), PTPRC(8), RELA(3), RPL13A(4), SFN(1), SLA(1), SP1(6), SP3(7), TGFB1(2), TRAF2(1), TRPV6(5), VAV1(6), VAV2(3), VAV3(7), XPO5(8)	127116583	369	245	324	68	34	67	48	66	153	1	0.185	1.000	1.000
411	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	91	ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(6), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), DRD1(1), DRD2(3), EGF(5), EGFR(5), GJA1(4), GJD2(2), GNA11(4), GNAI1(2), GNAI2(2), GNAI3(1), GNAQ(1), GNAS(11), GRM1(9), GRM5(4), GUCY1A2(6), GUCY1A3(2), GUCY1B3(2), GUCY2C(9), GUCY2D(4), GUCY2F(7), HRAS(2), HTR2A(5), HTR2C(6), ITPR1(15), ITPR2(18), ITPR3(14), KRAS(6), MAP2K1(5), MAP2K2(2), MAP2K5(1), MAP3K2(3), MAPK1(1), MAPK3(1), MAPK7(4), NPR1(5), NPR2(9), NRAS(2), PDGFB(2), PDGFRA(6), PDGFRB(7), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PRKACA(4), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(3), PRKG1(5), PRKG2(8), PRKX(5), RAF1(4), SOS1(5), SOS2(6), SRC(1), TJP1(8), TUBA1A(3), TUBA1B(2), TUBA1C(4), TUBA3C(4), TUBA3D(3), TUBA3E(3), TUBA4A(1), TUBA8(1), TUBAL3(2), TUBB(2), TUBB1(4), TUBB2B(3), TUBB3(2), TUBB6(2), TUBB8(5)	186562302	396	222	389	119	93	102	65	84	52	0	0.432	1.000	1.000
412	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(6), BRAF(5), CACNA1A(16), CRHR1(3), GNA11(4), GNA12(2), GNA13(1), GNAI1(2), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNAS(11), GNAZ(3), GRIA1(9), GRIA2(4), GRIA3(16), GRID2(11), GRM1(9), GRM5(4), GUCY1A2(6), GUCY1A3(2), GUCY1B3(2), GUCY2C(9), GUCY2D(4), GUCY2F(7), HRAS(2), IGF1R(7), ITPR1(15), ITPR2(18), ITPR3(14), KRAS(6), LYN(6), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), NOS1(13), NOS3(3), NPR1(5), NPR2(9), NRAS(2), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PPP2CA(3), PPP2CB(2), PPP2R1A(2), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PRKCA(4), PRKCG(3), PRKG1(5), PRKG2(8), RAF1(4), RYR1(29)	157961617	373	219	368	95	81	99	73	70	49	1	0.0573	1.000	1.000
413	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(6), AMY2A(5), AMY2B(1), ASCC3(7), ATP13A2(3), DDX18(3), DDX19A(1), DDX23(4), DDX4(6), DDX41(5), DDX47(1), DDX50(4), DDX51(3), DDX52(2), DDX54(3), DDX55(7), DDX56(2), DHX58(4), ENPP1(7), ENPP3(6), ENTPD7(6), EP400(13), ERCC2(3), ERCC3(5), G6PC(2), G6PC2(3), GAA(2), GANC(4), GBA(2), GBA3(4), GBE1(4), GCK(3), GPI(3), GUSB(6), GYS1(8), GYS2(1), HK1(3), HK2(5), HK3(5), IFIH1(4), LYZL1(1), MGAM(22), MOV10L1(7), NUDT5(2), NUDT8(1), PGM1(5), PGM3(2), PYGB(5), PYGL(3), PYGM(5), RAD54B(9), RAD54L(3), RUVBL2(1), SETX(18), SI(18), SKIV2L2(5), SMARCA2(11), SMARCA5(5), TREH(2), UGDH(1), UGP2(4), UGT1A1(4), UGT1A10(3), UGT1A3(3), UGT1A4(4), UGT1A6(2), UGT1A7(3), UGT1A8(2), UGT1A9(2), UGT2A1(7), UGT2B10(3), UGT2B11(1), UGT2B15(5), UGT2B17(2), UGT2B28(3), UGT2B4(3), UGT2B7(3), UXS1(3)	177904533	349	216	348	105	48	94	56	97	54	0	0.778	1.000	1.000
414	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(11), ABCA10(15), ABCA12(12), ABCA13(37), ABCA2(7), ABCA3(10), ABCA4(12), ABCA5(8), ABCA6(9), ABCA7(10), ABCA8(16), ABCA9(13), ABCB1(9), ABCB10(9), ABCB11(13), ABCB4(10), ABCB5(5), ABCB6(8), ABCB7(7), ABCB8(8), ABCB9(1), ABCC1(12), ABCC10(7), ABCC11(7), ABCC12(10), ABCC2(7), ABCC3(9), ABCC4(10), ABCC5(10), ABCC6(7), ABCC8(12), ABCC9(13), ABCD1(5), ABCD2(4), ABCD3(4), ABCD4(3), ABCG1(5), ABCG2(1), ABCG4(7), ABCG5(2), ABCG8(2), CFTR(14), TAP1(2)	167928951	383	209	381	100	53	112	72	86	58	2	0.0460	1.000	1.000
415	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(2), ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(6), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADK(2), ADSL(3), ADSS(3), AK1(1), AK2(1), AK5(4), ALLC(4), AMPD1(9), AMPD2(2), AMPD3(7), ATIC(3), ATP1B1(3), ATP5A1(4), ATP5B(1), ATP5C1(1), ATP5F1(3), ATP5G2(2), CANT1(2), DCK(1), DGUOK(4), ENPP1(7), ENPP3(6), ENTPD1(4), ENTPD2(3), FHIT(2), GART(3), GDA(2), GMPS(5), GUCY1A2(6), GUCY1A3(2), GUCY1B3(2), GUCY2C(9), GUCY2D(4), GUCY2F(7), GUK1(1), IMPDH1(2), IMPDH2(2), ITPA(1), NPR1(5), NPR2(9), NT5E(6), NUDT2(1), PAICS(3), PAPSS1(2), PAPSS2(2), PDE1A(5), PDE4A(1), PDE4B(12), PDE4C(5), PDE4D(8), PDE5A(7), PDE6B(3), PDE6C(6), PDE7B(1), PDE8A(1), PDE9A(5), PFAS(6), PKLR(5), POLB(1), POLD1(5), POLD2(1), POLE(10), POLG(7), POLL(3), POLQ(12), POLR1B(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2D(1), POLR2F(5), POLR2G(1), POLR2H(1), POLR2J(1), POLRMT(5), PPAT(5), PRPS2(1), PRUNE(4), RRM1(4), RRM2(1)	181269997	355	209	350	116	69	101	65	70	49	1	0.872	1.000	1.000
416	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(6), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), AKAP1(3), AKAP10(1), AKAP11(13), AKAP12(10), AKAP3(6), AKAP4(8), AKAP6(16), AKAP7(1), AKAP8(4), AKAP9(24), ARHGEF1(10), CALM2(2), GNA11(4), GNA12(2), GNA13(1), GNA14(1), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNAZ(3), GNB1(2), GNB2(1), GNB3(3), GNB5(2), HRAS(2), IL18BP(2), ITPR1(15), KCNJ3(2), KRAS(6), NRAS(2), PALM2(3), PDE1A(5), PDE1B(5), PDE1C(5), PDE4A(1), PDE4B(12), PDE4C(5), PDE4D(8), PDE7B(1), PDE8A(1), PDE8B(1), PLCB3(2), PPP3CA(5), PPP3CC(1), PRKACA(4), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKCA(4), PRKCD(5), PRKCE(8), PRKCG(3), PRKCH(3), PRKCI(1), PRKCQ(9), PRKCZ(2), PRKD1(6), PRKD3(6), RHOA(6), SLC9A1(4), USP5(7)	167272469	352	208	347	102	69	93	63	71	54	2	0.556	1.000	1.000
417	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	149	ADORA1(3), ADORA2A(4), ADORA3(1), ADRA1A(6), ADRA1B(1), ADRA2C(2), ADRB2(2), ADRB3(1), AGTR1(4), AGTR2(2), AVPR1B(5), AVPR2(3), BDKRB1(4), BDKRB2(4), BRS3(4), C3AR1(3), CCBP2(3), CCKAR(3), CCKBR(2), CCR1(3), CCR2(7), CCR3(2), CCR4(1), CCR5(1), CCR6(1), CCR7(4), CCR8(1), CCR9(1), CCRL1(1), CCRL2(4), CHML(4), CHRM1(4), CHRM2(6), CHRM3(3), CHRM4(1), CMKLR1(4), CNR1(1), CNR2(1), CX3CR1(3), CXCR3(6), CXCR4(3), DRD1(1), DRD2(3), DRD3(1), DRD5(4), EDNRA(3), EDNRB(2), F2R(4), F2RL1(1), F2RL2(2), FPR1(3), FSHR(9), GALR1(1), GALR2(2), GALR3(1), GALT(2), GHSR(2), GNB2L1(5), GPR17(2), GPR173(1), GPR174(4), GPR3(2), GPR35(1), GPR37(5), GPR37L1(1), GPR50(4), GPR6(2), GPR63(3), GPR77(2), GPR83(5), GPR85(2), GPR87(2), GRPR(3), HCRTR1(2), HCRTR2(2), HRH1(4), HRH2(4), HRH3(2), HTR1A(4), HTR1B(3), HTR1D(4), HTR1E(4), HTR1F(4), HTR2A(5), HTR2C(6), HTR5A(4), LHCGR(10), MAS1(2), MC3R(3), MC4R(2), MLNR(1), NMBR(3), NMUR1(3), NMUR2(3), NPY1R(5), NPY2R(3), NTSR2(2), OPN1SW(3), OPN3(1), OPRD1(3), OPRK1(2), OPRL1(3), OPRM1(5), OXTR(1), P2RY1(4), P2RY10(7), P2RY13(4), P2RY2(1), P2RY6(1), PPYR1(4), PTAFR(1), PTGDR(2), PTGER2(2), PTGER4(1), PTGFR(1), RGR(1), RHO(2), RRH(1), SSTR2(1), SSTR3(2), SSTR4(1)	154900991	343	204	343	123	78	72	61	93	38	1	0.388	1.000	1.000
418	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(6), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), CALM2(2), CALML6(1), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CREB1(2), CREB3(1), CREB3L1(3), CREB3L2(4), CREB3L3(8), CREB3L4(2), CREBBP(15), CTNNB1(2), DCT(4), DVL1(2), DVL3(1), EDN1(5), EDNRB(2), EP300(13), FZD1(3), FZD10(4), FZD2(4), FZD3(5), FZD4(1), FZD5(1), FZD6(4), FZD7(3), FZD8(1), FZD9(3), GNAI1(2), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNAS(11), GSK3B(2), HRAS(2), KIT(8), KITLG(3), KRAS(6), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), MITF(3), NRAS(2), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PRKACA(4), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(3), PRKX(5), RAF1(4), TCF7(4), TCF7L1(2), TCF7L2(5), TYR(5), TYRP1(7), WNT10B(1), WNT11(1), WNT16(2), WNT2(1), WNT2B(4), WNT3(1), WNT3A(1), WNT4(1), WNT5B(4), WNT6(1), WNT7A(6), WNT7B(1), WNT8B(2), WNT9A(1)	148458745	337	204	331	107	81	73	63	66	54	0	0.745	1.000	1.000
419	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(2), AKT3(4), BCAR1(6), CAPN1(8), CAPN10(5), CAPN11(3), CAPN2(8), CAPN3(3), CAPN6(3), CAPN7(2), CAPN9(1), CAV1(4), CRK(1), DOCK1(8), GIT2(1), ILK(3), ITGA10(10), ITGA11(7), ITGA2(4), ITGA2B(3), ITGA3(1), ITGA4(6), ITGA5(4), ITGA6(4), ITGA7(6), ITGA8(10), ITGA9(7), ITGAD(3), ITGAE(2), ITGAL(5), ITGAM(6), ITGAV(7), ITGAX(10), ITGB1(5), ITGB2(8), ITGB3(4), ITGB4(8), ITGB5(3), ITGB6(6), ITGB7(5), ITGB8(4), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K6(1), MAPK10(4), MAPK4(6), MAPK6(6), MAPK7(4), MYLK2(5), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PDPK1(2), PIK3R2(4), PTK2(7), RAP1B(1), RAPGEF1(5), RHO(2), ROCK1(8), ROCK2(9), SDCCAG8(6), SEPP1(3), SHC1(2), SHC3(1), SORBS1(7), SOS1(5), SRC(1), TLN1(16), TNS1(7), VAV2(3), VAV3(7), VCL(6), ZYX(2)	192453535	359	201	358	118	66	100	57	74	60	2	0.880	1.000	1.000
420	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(7), ACTB(5), ACTG1(8), ARHGEF2(5), ARPC5(1), ARPC5L(3), CD14(1), CDH1(108), CLDN1(1), CTNNB1(2), CTTN(2), EZR(1), HCLS1(2), ITGB1(5), KRT18(3), NCK1(2), NCK2(1), NCL(7), OCLN(3), PRKCA(4), RHOA(6), ROCK1(8), ROCK2(9), TLR4(15), TLR5(4), TUBA1A(3), TUBA1B(2), TUBA1C(4), TUBA3C(4), TUBA3D(3), TUBA3E(3), TUBA4A(1), TUBA8(1), TUBAL3(2), TUBB(2), TUBB1(4), TUBB2B(3), TUBB3(2), TUBB6(2), TUBB8(5), WAS(6), WASL(4), YWHAZ(3)	72872950	267	198	244	58	33	56	30	33	115	0	0.327	1.000	1.000
421	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(7), ACTB(5), ACTG1(8), ARHGEF2(5), ARPC5(1), ARPC5L(3), CD14(1), CDH1(108), CLDN1(1), CTNNB1(2), CTTN(2), EZR(1), HCLS1(2), ITGB1(5), KRT18(3), NCK1(2), NCK2(1), NCL(7), OCLN(3), PRKCA(4), RHOA(6), ROCK1(8), ROCK2(9), TLR4(15), TLR5(4), TUBA1A(3), TUBA1B(2), TUBA1C(4), TUBA3C(4), TUBA3D(3), TUBA3E(3), TUBA4A(1), TUBA8(1), TUBAL3(2), TUBB(2), TUBB1(4), TUBB2B(3), TUBB3(2), TUBB6(2), TUBB8(5), WAS(6), WASL(4), YWHAZ(3)	72872950	267	198	244	58	33	56	30	33	115	0	0.327	1.000	1.000
422	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(5), ADCY8(6), ARAF(6), ATF4(3), BRAF(5), CACNA1C(17), CALM2(2), CALML6(1), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CAMK4(5), CREBBP(15), EP300(13), GNAQ(1), GRIA1(9), GRIA2(4), GRIN1(3), GRIN2A(16), GRIN2B(11), GRIN2C(5), GRIN2D(5), GRM1(9), GRM5(4), HRAS(2), ITPR1(15), ITPR2(18), ITPR3(14), KRAS(6), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), NRAS(2), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PPP1CB(1), PPP1R12A(8), PPP1R1A(5), PPP3CA(5), PPP3CB(3), PPP3CC(1), PPP3R1(1), PRKACA(4), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(3), PRKX(5), RAF1(4), RAP1A(2), RAP1B(1), RAPGEF3(2), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), RPS6KA6(6)	145247538	341	196	335	101	71	88	58	70	54	0	0.419	1.000	1.000
423	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(8), BDKRB1(4), BDKRB2(4), C1QA(1), C1QB(1), C1R(6), C1S(1), C2(1), C3(8), C3AR1(3), C4BPA(4), C4BPB(1), C5(5), C5AR1(3), C6(8), C7(8), C8A(2), C8B(3), C8G(1), C9(5), CD46(2), CD55(3), CD59(2), CFB(4), CFH(13), CFI(1), CPB2(4), CR1(14), CR2(5), F10(5), F12(2), F13A1(5), F13B(5), F2(2), F2R(4), F5(26), F7(2), F8(20), F9(1), FGA(7), FGB(1), FGG(7), KLKB1(5), KNG1(4), MASP1(8), MASP2(2), MBL2(2), PLAT(6), PLAU(4), PLAUR(2), PLG(7), PROC(3), PROS1(4), SERPINA1(4), SERPINA5(5), SERPINC1(6), SERPIND1(1), SERPINE1(5), SERPINF2(2), SERPING1(3), TFPI(4), THBD(2), VWF(11)	128318001	302	194	300	80	47	72	72	63	47	1	0.339	1.000	1.000
424	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	ALG1(2), ALG10(3), ALG10B(6), ALG11(1), ALG12(3), ALG13(5), ALG14(1), ALG2(2), ALG3(1), ALG6(2), ALG8(2), ALG9(2), B3GNT1(1), B3GNT2(2), B3GNT7(2), B4GALT1(3), B4GALT3(2), B4GALT4(2), B4GALT5(4), B4GALT7(1), C1GALT1(3), C1GALT1C1(3), CHPF(2), CHST1(4), CHST11(1), CHST2(5), CHST3(1), CHST4(1), CHST7(1), CHSY1(3), DAD1(1), DDOST(2), DPAGT1(4), EXT1(7), EXT2(6), EXTL1(1), EXTL2(1), EXTL3(6), FUT11(3), FUT8(2), GALNT1(3), GALNT10(5), GALNT11(5), GALNT12(2), GALNT13(6), GALNT14(1), GALNT2(2), GALNT3(3), GALNT4(1), GALNT5(6), GALNT6(3), GALNT7(5), GALNT8(6), GALNT9(6), GALNTL1(3), GALNTL2(2), GALNTL4(1), GALNTL5(7), GANAB(10), GCNT3(1), GCNT4(3), HS2ST1(3), HS3ST1(2), HS3ST2(4), HS3ST3A1(1), HS3ST3B1(1), HS3ST5(5), HS6ST1(5), HS6ST2(7), HS6ST3(3), MAN1A1(6), MAN1A2(3), MAN1B1(3), MAN2A1(6), MGAT3(4), MGAT4A(4), MGAT4B(5), MGAT5(3), MGAT5B(8), NDST1(4), NDST2(1), NDST3(5), OGT(5), RPN1(4), RPN2(2), ST3GAL1(2), ST3GAL2(2), ST3GAL3(5), ST3GAL4(2), ST6GAL1(3), ST6GALNAC1(6), STT3B(3), UST(2), WBSCR17(7), XYLT1(4), XYLT2(5)	151670375	320	190	318	100	63	77	54	74	48	4	0.740	1.000	1.000
425	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	85	ACVR1B(8), ACVR1C(2), ACVR2A(8), ACVR2B(1), ACVRL1(1), AMHR2(3), BMP2(3), BMP4(2), BMP5(4), BMP6(2), BMP8B(2), BMPR1A(1), BMPR1B(6), BMPR2(8), CHRD(5), COMP(5), CREBBP(15), CUL1(2), DCN(2), E2F4(2), EP300(13), FST(3), GDF5(2), GDF6(1), ID1(1), ID2(2), ID3(1), IFNG(2), INHBA(4), INHBB(1), INHBC(1), INHBE(3), LEFTY2(1), LTBP1(9), MAPK1(1), MAPK3(1), MYC(1), NODAL(1), NOG(1), PITX2(5), PPP2CA(3), PPP2CB(2), PPP2R1A(2), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), RBL1(6), RHOA(6), ROCK1(8), ROCK2(9), RPS6KB1(4), RPS6KB2(5), SKP1(1), SMAD1(1), SMAD2(7), SMAD3(4), SMAD4(7), SMAD5(2), SMAD7(1), SMAD9(4), SMURF1(3), SMURF2(5), SP1(6), TFDP1(3), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TGFBR2(4), THBS1(8), THBS2(2), THBS3(5), THBS4(4), ZFYVE16(5), ZFYVE9(4)	137911792	270	177	265	70	52	65	28	66	59	0	0.463	1.000	1.000
426	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	82	ANPEP(8), CD14(1), CD19(6), CD1A(2), CD1B(5), CD1C(4), CD1D(3), CD1E(7), CD2(4), CD22(5), CD33(2), CD34(3), CD36(5), CD37(3), CD38(3), CD3E(3), CD3G(3), CD4(4), CD44(4), CD5(3), CD55(3), CD59(2), CD7(1), CD8A(3), CD8B(3), CD9(2), CR1(14), CR2(5), CSF1(5), CSF1R(3), CSF2RA(3), CSF3(2), CSF3R(6), DNTT(6), EPO(1), EPOR(4), FCER2(1), FCGR1A(5), FLT3(4), FLT3LG(1), GP5(3), GYPA(1), HLA-DRB1(10), HLA-DRB5(5), IL11(1), IL11RA(5), IL1A(1), IL1R1(1), IL1R2(4), IL2RA(2), IL3(1), IL3RA(3), IL4(1), IL4R(6), IL5RA(4), IL6(2), IL6R(5), IL7(1), IL7R(4), IL9R(2), ITGA1(6), ITGA2(4), ITGA2B(3), ITGA3(1), ITGA4(6), ITGA5(4), ITGA6(4), ITGAM(6), ITGB3(4), KIT(8), KITLG(3), MME(1), MS4A1(1), TFRC(2), THPO(3), TPO(8)	116815928	278	171	278	79	43	68	56	64	46	1	0.480	1.000	1.000
427	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	90	CD2BP2(1), CDC40(3), CLK2(6), CLK3(4), CLK4(3), COL2A1(4), CPSF1(10), CPSF2(3), CPSF3(6), CPSF4(4), CSTF1(1), CSTF2(2), CSTF2T(4), CSTF3(8), DDX1(3), DDX20(4), DHX15(9), DHX16(2), DHX38(4), DHX8(7), DHX9(8), DICER1(8), DNAJC8(1), FUS(3), GIPC1(1), METTL3(2), NCBP1(1), NCBP2(1), NONO(2), NUDT21(1), NXF1(8), PABPN1(1), PAPOLA(5), POLR2A(6), PPM1G(2), PRPF18(2), PRPF3(5), PRPF4(3), PRPF4B(9), PRPF8(12), PSKH1(3), PTBP1(6), PTBP2(3), RBM17(1), RBM5(5), RNGTT(2), RNMT(1), RNPS1(2), SF3A1(2), SF3A2(1), SF3A3(1), SF3B1(16), SF3B2(5), SF3B4(3), SF3B5(1), SNRPA(1), SNRPB(2), SNRPD2(2), SNRPG(2), SNRPN(3), SPOP(5), SRPK1(3), SRPK2(5), SRRM1(6), SUPT5H(12), TXNL4A(1), U2AF1(1), U2AF2(1), XRN2(4)	149670972	269	163	262	59	31	73	47	71	45	2	0.193	1.000	1.000
428	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	68	ACACB(13), ACSL1(3), ACSL3(3), ACSL4(5), ACSL5(5), ACSL6(4), ADIPOR1(1), ADIPOR2(2), AGRP(1), AKT1(2), AKT2(5), AKT3(4), CAMKK1(3), CAMKK2(4), CD36(5), CHUK(8), CPT1A(6), CPT1B(4), CPT1C(7), CPT2(5), G6PC(2), G6PC2(3), IKBKB(6), IRS1(4), IRS4(7), JAK1(11), JAK2(7), JAK3(8), LEP(1), LEPR(7), MAPK10(4), MAPK8(2), MAPK9(1), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), NPY(1), PCK1(5), PCK2(4), PPARA(4), PPARGC1A(6), PRKAA1(3), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKAG1(2), PRKAG2(2), PRKAG3(3), PRKCQ(9), PTPN11(1), RELA(3), RXRA(2), RXRG(2), SLC2A4(3), STAT3(5), STK11(2), TNFRSF1A(4), TNFRSF1B(2), TRAF2(1), TYK2(8)	113465716	246	154	243	67	48	55	41	46	54	2	0.394	1.000	1.000
429	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	66	ADAM10(3), ATP6AP1(2), ATP6V0A1(6), ATP6V0A2(3), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V0D2(2), ATP6V0E1(2), ATP6V1A(4), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1E2(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), CASP3(1), CHUK(8), EGFR(5), F11R(4), GIT1(3), IGSF5(3), IKBKB(6), IL8(1), JAM2(1), JUN(3), LYN(6), MAP2K4(32), MAPK10(4), MAPK13(1), MAPK14(2), MAPK8(2), MAPK9(1), MET(10), NFKB1(5), NFKB2(5), NFKBIA(3), NOD1(6), PAK1(4), PLCG1(8), PLCG2(8), PTPN11(1), PTPRZ1(11), RELA(3), SRC(1), TCIRG1(4), TJP1(8)	101450068	211	150	205	53	36	55	33	25	62	0	0.362	1.000	1.000
430	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	48	ADORA3(1), ALG6(2), CCKBR(2), CCR2(7), CCR3(2), CCR5(1), CELSR1(14), CELSR2(14), CELSR3(12), CHRM2(6), CHRM3(3), CIDEB(2), CXCR3(6), EDNRA(3), EMR2(9), EMR3(7), F2R(4), FSHR(9), GHRHR(5), GPR116(7), GPR132(1), GPR133(6), GPR135(1), GPR143(4), GPR17(2), GPR55(3), GPR56(3), GPR61(2), GPR77(2), GPR84(7), GRM1(9), GRPR(3), HRH4(2), LGR6(5), LPHN2(11), LPHN3(8), P2RY13(4), PTGFR(1), SMO(5), SSTR2(1), TAAR5(4), TSHR(7), VN1R1(1)	87242127	208	145	208	64	29	53	33	56	37	0	0.311	1.000	1.000
431	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	84	AK3(2), CAD(17), CANT1(2), CDA(1), CTPS2(3), DCK(1), DPYD(2), DPYS(3), DTYMK(2), DUT(1), ENTPD1(4), ENTPD3(1), ENTPD4(4), ENTPD5(7), ENTPD6(4), ENTPD8(1), ITPA(1), NME6(1), NME7(4), NT5C1A(2), NT5C1B(6), NT5C2(3), NT5C3(4), NT5E(6), NUDT2(1), PNPT1(5), POLA1(15), POLA2(6), POLD1(5), POLD2(1), POLE(10), POLE2(2), POLE3(1), POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2D(1), POLR2F(5), POLR2G(1), POLR2H(1), POLR2J(1), POLR3A(5), POLR3B(2), POLR3GL(3), POLR3H(1), POLR3K(1), PRIM1(1), RFC5(1), RRM1(4), RRM2(1), RRM2B(1), TK1(1), TK2(1), TXNRD1(6), TXNRD2(3), TYMS(1), UCK1(1), UCK2(2), UMPS(4), UPB1(3), UPP1(3), UPRT(3)	115776082	217	143	215	66	36	62	38	49	31	1	0.724	1.000	1.000
432	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(5), CPEB1(7), EGFR(5), ERBB2(23), ERBB4(14), ETS1(3), ETS2(7), ETV6(4), ETV7(3), FMN2(17), KRAS(6), MAP2K1(5), MAPK1(1), MAPK3(1), NOTCH1(8), NOTCH2(18), NOTCH3(11), NOTCH4(13), PIWIL1(17), PIWIL2(5), PIWIL3(7), PIWIL4(4), RAF1(4), SOS1(5), SOS2(6), SPIRE1(2)	69176856	201	143	187	47	22	52	45	49	32	1	0.199	1.000	1.000
433	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	70	B2M(3), CALR(1), CANX(3), CD4(4), CD74(2), CD8A(3), CD8B(3), CIITA(5), CREB1(2), CTSB(2), CTSL1(4), CTSS(3), HLA-A(3), HLA-B(6), HLA-C(9), HLA-DMA(1), HLA-DMB(3), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(3), HLA-DRB1(10), HLA-DRB5(5), HLA-F(5), HLA-G(1), HSP90AA1(3), HSP90AB1(5), HSPA5(5), IFI30(1), IFNA1(1), IFNA10(3), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(3), IFNA2(3), IFNA21(4), IFNA4(2), IFNA6(1), IFNA7(2), IFNA8(2), KIR2DL1(3), KIR2DL3(3), KIR2DL4(4), KIR2DS4(4), KIR3DL1(3), KIR3DL2(6), KIR3DL3(3), KLRC1(5), KLRC3(1), KLRD1(1), LGMN(2), LTA(2), NFYB(1), NFYC(4), PSME1(1), RFX5(3), RFXANK(3), RFXAP(1), TAP1(2)	56801649	179	131	178	49	21	49	50	31	27	1	0.385	1.000	1.000
434	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(6), ADCY6(2), ADCY8(6), CACNA1A(16), CACNA1B(14), GNAS(11), GNAT3(1), GNB1(2), GNB3(3), GRM4(3), ITPR3(14), KCNB1(7), PDE1A(5), PLCB2(7), PRKACA(4), PRKACB(1), PRKACG(3), PRKX(5), SCNN1A(3), SCNN1B(2), SCNN1G(1), TAS1R1(3), TAS1R2(4), TAS1R3(1), TAS2R1(4), TAS2R10(4), TAS2R13(2), TAS2R14(2), TAS2R16(5), TAS2R3(3), TAS2R38(2), TAS2R39(1), TAS2R40(2), TAS2R41(2), TAS2R42(2), TAS2R43(4), TAS2R46(2), TAS2R5(2), TAS2R50(1), TAS2R8(2), TAS2R9(2), TRPM5(10)	80411911	176	130	174	46	37	44	32	34	29	0	0.120	1.000	1.000
435	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	92	ANK2(28), B3GALT4(2), CDR1(2), DGKI(7), IL6ST(9), RPL10(2), RPL12(1), RPL13A(4), RPL15(1), RPL18(1), RPL18A(4), RPL19(2), RPL23(1), RPL24(1), RPL26(1), RPL3(4), RPL31(1), RPL32(1), RPL35(1), RPL36(1), RPL3L(3), RPL4(1), RPL41(1), RPL5(2), RPL7(1), RPL8(2), RPL9(1), RPLP0(2), RPLP2(1), RPS10(1), RPS12(1), RPS14(1), RPS16(1), RPS18(1), RPS2(1), RPS25(1), RPS27(1), RPS29(1), RPS4X(2), RPS5(6), RPS6(4), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), RPS6KA6(6), RPS6KB1(4), RPS6KB2(5), RPS8(1), RPS9(2), SLC36A2(5), TBC1D10C(4), TSPAN9(3), UBA52(2), UBC(13)	75106080	174	126	172	47	38	49	32	29	25	1	0.480	1.000	1.000
436	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(1), ADH1C(4), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), AGK(4), AGPAT1(1), AGPAT3(2), AGPAT4(2), AGPAT6(3), AKR1A1(1), AKR1B1(3), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), CEL(4), DAK(4), DGAT1(2), DGAT2(2), DGKA(2), DGKB(5), DGKD(10), DGKE(4), DGKG(8), DGKH(4), DGKI(7), DGKQ(2), DGKZ(1), GK(6), GK2(4), GLA(5), GLB1(4), GPAM(6), LCT(17), LIPA(4), LIPC(2), LIPF(1), LIPG(3), LPL(1), MGLL(2), PNLIP(5), PNLIPRP1(4), PNLIPRP2(1), PNPLA3(3), PPAP2A(2), PPAP2C(1)	83683793	177	125	175	43	35	35	40	33	33	1	0.0923	1.000	1.000
437	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(23), AXIN1(5), CCND1(1), CCND2(3), CCND3(5), CSNK1E(4), CTNNB1(2), DVL1(2), DVL3(1), FBXW2(4), FZD1(3), FZD10(4), FZD2(4), FZD3(5), FZD5(1), FZD6(4), FZD7(3), FZD8(1), FZD9(3), GSK3B(2), JUN(3), LDLR(6), MAPK10(4), MAPK9(1), MYC(1), PAFAH1B1(3), PLAU(4), PPP2R5C(6), PPP2R5E(2), PRKCA(4), PRKCD(5), PRKCE(8), PRKCG(3), PRKCH(3), PRKCI(1), PRKCQ(9), PRKCZ(2), PRKD1(6), RHOA(6), SFRP4(2), TCF7(4), WNT10B(1), WNT11(1), WNT16(2), WNT2(1), WNT2B(4), WNT3(1), WNT4(1), WNT5B(4), WNT6(1), WNT7A(6), WNT7B(1)	80062020	186	125	185	52	45	39	29	35	34	4	0.507	1.000	1.000
438	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(6), AMY2A(5), AMY2B(1), ENPP1(7), ENPP3(6), G6PC(2), GAA(2), GANAB(10), GBA3(4), GBE1(4), GCK(3), GPI(3), GUSB(6), GYS1(8), GYS2(1), HK1(3), HK2(5), HK3(5), MGAM(22), PGM1(5), PGM3(2), PYGB(5), PYGL(3), PYGM(5), RNPC3(2), SI(18), UCHL3(2), UGDH(1), UGT1A1(4), UGT1A10(3), UGT1A3(3), UGT1A4(4), UGT1A6(2), UGT1A7(3), UGT1A8(2), UGT1A9(2), UGT2B15(5), UGT2B4(3), UXS1(3)	82974920	180	123	179	69	28	40	33	55	24	0	0.982	1.000	1.000
439	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	66	ACAA1(1), ACADL(1), ACOX1(4), ACOX2(4), ACOX3(5), ACSL1(3), ACSL3(3), ACSL4(5), ACSL5(5), ACSL6(4), ANGPTL4(1), APOA1(3), APOA5(3), AQP7(1), CD36(5), CPT1A(6), CPT1B(4), CPT1C(7), CPT2(5), CYP27A1(1), CYP4A11(8), CYP4A22(2), CYP7A1(3), CYP8B1(3), DBI(1), EHHADH(4), FABP1(2), FABP2(1), FABP3(1), FABP6(1), FABP7(1), FADS2(7), GK(6), GK2(4), HMGCS2(3), ILK(3), LPL(1), MMP1(2), NR1H3(2), OLR1(2), PCK1(5), PCK2(4), PDPK1(2), PLTP(3), PPARA(4), PPARD(2), PPARG(5), RXRA(2), RXRG(2), SCD(1), SCP2(1), SLC27A1(2), SLC27A2(2), SLC27A4(6), SLC27A5(4), SORBS1(7), UBC(13)	91423213	193	122	192	64	32	49	38	46	27	1	0.793	1.000	1.000
440	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	APH1A(2), CREBBP(15), CTBP1(1), CTBP2(1), DLL1(5), DLL3(2), DLL4(2), DTX1(4), DTX2(3), DTX3(3), DTX3L(4), DTX4(2), DVL1(2), DVL3(1), EP300(13), HDAC1(5), HDAC2(2), HES1(1), JAG1(9), JAG2(1), MAML1(3), MAML2(4), MAML3(7), NCOR2(8), NCSTN(7), NOTCH1(8), NOTCH2(18), NOTCH3(11), NOTCH4(13), NUMB(5), NUMBL(3), PSEN1(2), PSEN2(4), PSENEN(2), PTCRA(3), RBPJL(5), RFNG(2), SNW1(2)	90067017	185	122	184	69	41	35	39	31	39	0	0.975	1.000	1.000
441	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	65	AGTR1(4), AGTR2(2), ATP8A1(4), AVPR1B(5), AVPR2(3), BDKRB1(4), BDKRB2(4), BRS3(4), C3AR1(3), CCKAR(3), CCKBR(2), CCR1(3), CCR2(7), CCR3(2), CCR4(1), CCR5(1), CCR6(1), CCR7(4), CCR8(1), CX3CR1(3), CXCR3(6), CXCR4(3), CXCR6(1), EDNRA(3), EDNRB(2), FPR1(3), FSHR(9), GALR1(1), GALR2(2), GALR3(1), GALT(2), GHSR(2), GNB2L1(5), GPR77(2), GRPR(3), LHCGR(10), MC2R(2), MC3R(3), MC4R(2), NMBR(3), NPY1R(5), NPY2R(3), NTSR2(2), OPRD1(3), OPRK1(2), OPRL1(3), OPRM1(5), OXTR(1), PPYR1(4), SSTR2(1), SSTR3(2), SSTR4(1), TACR1(2), TACR2(4), TACR3(2), TSHR(7)	71625023	173	120	173	50	31	45	29	48	19	1	0.107	1.000	1.000
442	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AANAT(1), ABP1(1), ACAT1(3), AFMID(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), AOC2(6), AOC3(3), AOX1(7), ASMT(1), CARM1(5), CAT(2), CYP1A1(1), CYP1A2(2), CYP1B1(2), DDC(4), EHHADH(4), GCDH(2), HAAO(2), HADH(2), HADHA(3), HEMK1(2), HSD17B10(1), HSD17B4(8), INMT(4), KMO(8), KYNU(3), LCMT1(1), LCMT2(10), LNX1(6), MAOA(2), MAOB(4), METTL2B(4), METTL6(1), NFX1(4), OGDH(7), OGDHL(6), PRMT2(5), PRMT3(3), PRMT5(6), PRMT6(2), PRMT7(3), PRMT8(4), TDO2(2), TPH1(3), TPH2(4), WARS2(2), WBSCR22(2)	86417772	176	119	175	58	24	53	42	30	25	2	0.809	1.000	1.000
443	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(3), AGPAT1(1), AGPAT3(2), AGPAT4(2), AGPAT6(3), CDS1(3), CDS2(3), CHAT(2), CHKA(1), CHKB(5), CHPT1(4), CRLS1(3), DGKA(2), DGKB(5), DGKD(10), DGKE(4), DGKG(8), DGKH(4), DGKI(7), DGKQ(2), DGKZ(1), ESCO1(4), ESCO2(1), ETNK1(4), ETNK2(4), GNPAT(5), GPAM(6), GPD1(6), GPD1L(1), GPD2(3), LCAT(1), PCYT1A(2), PCYT1B(6), PEMT(1), PHOSPHO1(1), PISD(1), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLD1(7), PLD2(2), PNPLA3(3), PPAP2A(2), PPAP2C(1), PTDSS1(5), PTDSS2(3), SH3GLB1(2)	92670771	165	118	164	45	27	38	29	44	26	1	0.327	1.000	1.000
444	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(3), BMP4(2), BMP5(4), BMP6(2), BMP8B(2), BTRC(4), CSNK1A1(4), CSNK1A1L(4), CSNK1E(4), CSNK1G1(1), CSNK1G2(2), CSNK1G3(1), GLI1(5), GLI2(12), GLI3(11), GSK3B(2), HHIP(1), IHH(2), LRP2(33), PRKACA(4), PRKACB(1), PRKACG(3), PRKX(5), PTCH1(11), PTCH2(2), SHH(1), SMO(5), STK36(1), SUFU(3), WNT10B(1), WNT11(1), WNT16(2), WNT2(1), WNT2B(4), WNT3(1), WNT3A(1), WNT4(1), WNT5B(4), WNT6(1), WNT7A(6), WNT7B(1), WNT8B(2), WNT9A(1), ZIC2(1)	80608756	163	117	162	54	48	38	26	32	19	0	0.729	1.000	1.000
445	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(2), AKT2(5), AKT3(4), ASAH1(1), BRAF(5), DAG1(2), DRD2(3), EGFR(5), EPHB2(5), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), KCNJ3(2), KCNJ5(1), KCNJ9(1), MAPK1(1), PI3(1), PIK3CB(8), PITX2(5), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), RAF1(4), RGS20(4), SHC1(2), SOS1(5), SOS2(6), SRC(1), STAT3(5), TERF2IP(3)	83303492	175	117	173	41	30	46	19	49	31	0	0.110	1.000	1.000
446	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASDHPPT(4), AASS(5), ACAT1(3), AKR1B10(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), BBOX1(2), DLST(3), DOT1L(10), EHHADH(4), EHMT1(9), EHMT2(6), GCDH(2), HADH(2), HADHA(3), HSD17B10(1), HSD17B4(8), HSD3B7(1), NSD1(13), OGDH(7), OGDHL(6), PIPOX(2), PLOD1(2), PLOD2(2), PLOD3(9), RDH11(4), RDH12(2), RDH13(2), RDH14(2), SETD1A(4), SETD7(5), SETDB1(11), SHMT1(1), SHMT2(4), SPCS3(1), SUV39H1(2), SUV39H2(1), TMLHE(1)	79094475	162	116	159	46	25	42	40	32	23	0	0.504	1.000	1.000
447	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	43	CBL(4), CD28(2), CTLA4(1), DAG1(2), DTYMK(2), EPHB2(5), FBXW7(15), GRAP2(2), ITK(7), ITPKA(1), ITPKB(8), LAT(1), LCK(2), LCP2(2), MAPK1(1), NCK1(2), NFAT5(7), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PAK7(4), PLCG1(8), PTPRC(8), RAF1(4), RASGRP2(6), RASGRP3(2), RASGRP4(5), SOS1(5), SOS2(6), VAV1(6), ZAP70(3)	78167444	157	116	155	56	31	42	20	35	29	0	0.954	1.000	1.000
448	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPL(1), ALPP(3), ALPPL2(2), ASCC3(7), ATP13A2(3), DDX18(3), DDX19A(1), DDX23(4), DDX4(6), DDX41(5), DDX47(1), DDX50(4), DDX51(3), DDX52(2), DDX54(3), DDX55(7), DDX56(2), DHX58(4), ENTPD7(6), EP400(13), ERCC2(3), ERCC3(5), FPGS(4), GCH1(1), IFIH1(4), MOV10L1(7), NUDT5(2), NUDT8(1), QDPR(1), RAD54B(9), RAD54L(3), RUVBL2(1), SETX(18), SKIV2L2(5), SMARCA2(11), SMARCA5(5)	88654516	160	115	160	35	25	46	29	33	27	0	0.112	1.000	1.000
449	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	54	ABP1(1), ADH1A(1), ADH1C(4), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), ALDH1A3(7), ALDH3A1(3), ALDH3B2(4), AOC2(6), AOC3(3), AOX1(7), CARM1(5), COMT(1), DBH(6), DCT(4), DDC(4), ECH1(1), ESCO1(4), ESCO2(1), FAH(3), GOT1(2), GOT2(1), GSTZ1(1), HEMK1(2), HGD(4), HPD(4), LCMT1(1), LCMT2(10), MAOA(2), MAOB(4), METTL2B(4), METTL6(1), PNMT(1), PNPLA3(3), PRMT2(5), PRMT3(3), PRMT5(6), PRMT6(2), PRMT7(3), PRMT8(4), SH3GLB1(2), TAT(3), TH(2), TPO(8), TYR(5), TYRP1(7), WBSCR22(2)	82655347	170	113	167	40	31	40	41	26	30	2	0.188	1.000	1.000
450	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(9), COL4A2(9), COL4A3(6), COL4A4(9), COL4A5(12), COL4A6(10), F10(5), F12(2), F2(2), F2R(4), F5(26), F8(20), F9(1), FGA(7), FGB(1), FGG(7), KLKB1(5), PROC(3), PROS1(4), SERPINC1(6), SERPING1(3)	64590142	151	110	151	38	22	35	41	29	24	0	0.309	1.000	1.000
451	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(3), AKT1(2), BDKRB2(4), CALM2(2), CAV1(4), CHRM1(4), CHRNA1(4), FLT1(5), FLT4(3), KDR(8), NOS3(3), PDE2A(4), PDE3A(12), PDE3B(4), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKG1(5), PRKG2(8), RYR2(53), SYT1(2)	58864376	145	108	144	64	20	42	30	31	20	2	0.995	1.000	1.000
452	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(3), ATP4A(8), ATP4B(3), ATP5A1(4), ATP5B(1), ATP5C1(1), ATP5F1(3), ATP5G2(2), ATP5L(1), ATP5O(2), ATP6AP1(2), ATP6V0A1(6), ATP6V0A2(3), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V0D2(2), ATP6V0E1(2), ATP6V1A(4), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1E2(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), COX10(7), COX15(3), COX17(2), COX4I2(2), COX5A(1), COX5B(1), COX6A1(1), COX6C(1), COX7A2(2), COX7B2(3), NDUFA1(2), NDUFA10(1), NDUFA13(1), NDUFA2(1), NDUFA4(1), NDUFA4L2(1), NDUFA6(1), NDUFA7(1), NDUFA9(3), NDUFB1(2), NDUFB10(1), NDUFB3(1), NDUFB5(4), NDUFB6(2), NDUFB8(1), NDUFB9(3), NDUFS1(1), NDUFS2(7), NDUFS3(1), NDUFS5(1), NDUFS6(1), NDUFS7(2), NDUFS8(1), NDUFV1(5), NDUFV2(1), NDUFV3(5), PPA1(4), PPA2(2), SDHB(2), SDHD(1), TCIRG1(4), UQCRB(1), UQCRC1(1), UQCRC2(4), UQCRFS1(1)	80638428	170	107	170	41	29	48	28	36	29	0	0.118	1.000	1.000
453	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(1), ADH1C(4), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), AKR1C1(5), AKR1C2(3), AKR1C3(1), AKR1C4(3), ALDH1A3(7), ALDH3A1(3), ALDH3B2(4), CYP1A1(1), CYP1A2(2), CYP1B1(2), CYP2B6(5), CYP2C18(2), CYP2C19(6), CYP2C8(3), CYP2C9(3), CYP2E1(2), CYP2F1(5), CYP2S1(6), CYP3A4(4), CYP3A43(3), CYP3A5(2), CYP3A7(5), DHDH(1), EPHX1(3), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTK1(3), GSTM4(2), GSTM5(1), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(1), MGST3(2), UGT1A1(4), UGT1A10(3), UGT1A3(3), UGT1A4(4), UGT1A6(2), UGT1A7(3), UGT1A8(2), UGT1A9(2), UGT2A1(7), UGT2B10(3), UGT2B11(1), UGT2B15(5), UGT2B17(2), UGT2B28(3), UGT2B4(3), UGT2B7(3)	81645445	169	107	167	55	18	45	36	47	23	0	0.716	1.000	1.000
454	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3(2), CAD(17), CANT1(2), CDA(1), CTPS2(3), DCK(1), DPYD(2), DPYS(3), DTYMK(2), DUT(1), ENTPD1(4), ITPA(1), NT5E(6), NUDT2(1), POLB(1), POLD1(5), POLD2(1), POLE(10), POLG(7), POLL(3), POLQ(12), POLR1B(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2D(1), POLR2F(5), POLR2G(1), POLR2H(1), POLR2J(1), POLRMT(5), RRM1(4), RRM2(1), TK1(1), TK2(1), TXNRD1(6), TYMS(1), UCK1(1), UCK2(2), UMPS(4), UPB1(3), UPP1(3)	80973631	142	106	140	48	23	42	21	29	26	1	0.894	1.000	1.000
455	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(14), CARM1(5), CCND1(1), CREBBP(15), EP300(13), ERCC3(5), ESR1(7), GRIP1(7), GTF2A1(2), GTF2E1(2), GTF2F1(1), HDAC1(5), HDAC2(2), HDAC3(1), HDAC4(6), HDAC5(6), HDAC6(16), MEF2C(4), NCOR2(8), NRIP1(10), PELP1(7), POLR2A(6), SRA1(1), TBP(2)	66529685	146	105	145	41	20	34	26	30	36	0	0.694	1.000	1.000
456	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	63	ACSS1(1), ACSS2(2), ACYP1(2), ADH1A(1), ADH1C(4), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), AKR1A1(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH3B2(4), ALDH9A1(1), ALDOA(5), ALDOB(3), ALDOC(2), BPGM(1), DLAT(2), DLD(1), ENO2(1), ENO3(2), FBP1(2), G6PC(2), G6PC2(3), GALM(1), GAPDH(1), GAPDHS(2), GCK(3), GPI(3), HK1(3), HK2(5), HK3(5), LDHA(3), LDHC(4), PDHA1(2), PDHA2(4), PDHB(1), PFKL(1), PFKM(8), PFKP(7), PGAM2(1), PGAM4(2), PGK1(6), PGK2(1), PGM1(5), PGM3(2), PKLR(5), TPI1(2)	81976631	146	104	143	33	21	37	35	31	22	0	0.0574	1.000	1.000
457	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG1(8), ACTG2(4), ACTR2(2), ACTR3(2), AKT1(2), ANGPTL2(1), CFL1(1), CFL2(1), FLNA(20), FLNC(21), FSCN1(1), FSCN3(1), GDI1(3), GDI2(2), LIMK1(8), MYH2(9), MYLK(11), MYLK2(5), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PAK7(4), RHO(2), ROCK1(8), ROCK2(9), RPS4X(2), WASF1(6), WASL(4)	65416441	156	104	155	49	33	31	29	33	29	1	0.766	1.000	1.000
458	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	52	AKR1C4(3), AKR1D1(1), ARSE(4), CARM1(5), CYP11B1(5), CYP11B2(4), HEMK1(2), HSD11B1(3), HSD11B2(2), HSD17B1(1), HSD17B2(4), HSD17B3(2), HSD17B7(1), HSD3B1(3), HSD3B2(4), LCMT1(1), LCMT2(10), METTL2B(4), METTL6(1), PRMT2(5), PRMT3(3), PRMT5(6), PRMT6(2), PRMT7(3), PRMT8(4), SRD5A1(4), STS(1), SULT1E1(4), SULT2B1(2), UGT1A1(4), UGT1A10(3), UGT1A3(3), UGT1A4(4), UGT1A6(2), UGT1A7(3), UGT1A8(2), UGT1A9(2), UGT2A1(7), UGT2B10(3), UGT2B11(1), UGT2B15(5), UGT2B17(2), UGT2B28(3), UGT2B4(3), UGT2B7(3), WBSCR22(2)	69242281	146	103	145	47	14	45	33	30	23	1	0.727	1.000	1.000
459	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(5), F12(2), F13B(5), F2(2), F5(26), F7(2), F8(20), F9(1), FGA(7), FGB(1), FGG(7), LPA(16), PLAT(6), PLAU(4), PLG(7), SERPINB2(1), SERPINE1(5), SERPINF2(2), VWF(11)	49965990	130	100	128	36	19	25	37	27	22	0	0.479	1.000	1.000
460	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(1), ADH1C(4), ADH4(1), ADH6(2), ADH7(3), ADHFE1(2), AGPAT1(1), AGPAT3(2), AGPAT4(2), AKR1A1(1), AKR1B1(3), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), CEL(4), DGAT1(2), DGKA(2), DGKB(5), DGKD(10), DGKE(4), DGKG(8), DGKH(4), DGKQ(2), DGKZ(1), GK(6), GLA(5), GLB1(4), LCT(17), LIPC(2), LIPF(1), LIPG(3), LPL(1), PNLIP(5), PNLIPRP1(4), PNLIPRP2(1), PPAP2A(2), PPAP2C(1)	68462312	138	100	136	39	30	25	30	24	29	0	0.369	1.000	1.000
461	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(2), ATF1(3), CREB1(2), CREB3(1), CREB5(4), DUSP1(1), DUSP10(9), EEF2K(6), ELK1(4), IL1R1(1), MAP2K3(3), MAP2K4(32), MAP2K6(1), MAP3K10(3), MAP3K4(8), MAP3K5(12), MAP3K7(3), MAPK1(1), MAPK13(1), MAPK14(2), MAPKAPK2(1), MKNK1(2), MKNK2(4), MYEF2(3), NFKB1(5), NR2C2(2), SRF(1), TRAF6(4)	47266500	121	100	115	37	18	23	19	24	37	0	0.849	1.000	1.000
462	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(3), AGPAT1(1), AGPAT3(2), AGPAT4(2), AGPS(1), CDS1(3), CDS2(3), CHAT(2), CHKA(1), CHKB(5), CLC(1), CPT1B(4), DGKA(2), DGKB(5), DGKD(10), DGKE(4), DGKG(8), DGKH(4), DGKQ(2), DGKZ(1), ETNK1(4), GNPAT(5), GPD1(6), GPD2(3), LCAT(1), LGALS13(3), PAFAH1B1(3), PCYT1A(2), PCYT1B(6), PEMT(1), PISD(1), PLA2G1B(1), PLA2G2A(1), PLA2G2E(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLCB2(7), PLCG1(8), PLCG2(8), PPAP2A(2), PPAP2C(1)	70080437	139	99	138	39	24	29	21	35	29	1	0.392	1.000	1.000
463	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(3), ACTN1(6), ACTN2(10), ACTN3(7), BCAR1(6), BCR(3), CAPN1(8), CAV1(4), CRKL(1), HRAS(2), ITGA1(6), ITGB1(5), JUN(3), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), MAPK8(2), PPP1R12B(4), PTK2(7), RAF1(4), RAP1A(2), ROCK1(8), SHC1(2), SOS1(5), SRC(1), TLN1(16), VCL(6), ZYX(2)	66653621	132	99	132	46	28	34	17	25	26	2	0.900	1.000	1.000
464	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ACTR3(2), ARHGAP1(4), ARHGAP4(6), ARHGAP5(12), ARHGAP6(5), ARHGEF1(10), ARHGEF11(6), ARHGEF5(10), ARPC1A(3), ARPC1B(2), ARPC2(5), BAIAP2(2), CFL1(1), DIAPH1(5), GSN(2), LIMK1(8), MYLK(11), OPHN1(4), PIP5K1A(6), PIP5K1B(2), PPP1R12B(4), ROCK1(8), SRC(1), TLN1(16), VCL(6)	65837122	143	97	140	50	22	33	25	23	40	0	0.946	1.000	1.000
465	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(9), AARS2(5), CARS(5), CARS2(5), DARS(4), DARS2(2), EARS2(3), EPRS(11), FARS2(4), FARSA(3), FARSB(5), GARS(2), HARS(1), IARS(8), IARS2(5), LARS(5), LARS2(3), MARS(11), MARS2(1), NARS(1), NARS2(2), PARS2(2), QARS(10), RARS(5), RARS2(3), SARS(4), TARS(8), TARS2(11), VARS(2), VARS2(1), WARS2(2), YARS(4), YARS2(1)	74308153	148	96	146	36	19	54	20	31	24	0	0.278	1.000	1.000
466	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	39	ALK(8), AR(6), ESR1(7), ESR2(5), HNF4A(2), NR1D1(5), NR1D2(2), NR1H2(7), NR1H3(2), NR1I2(2), NR1I3(2), NR2C2(2), NR2E1(3), NR2F1(1), NR2F2(1), NR3C1(3), NR4A1(3), NR4A2(3), NR5A1(1), NR5A2(7), PGR(6), PPARA(4), PPARD(2), PPARG(5), RARA(1), RARB(6), RARG(3), ROR1(9), RORA(1), RORC(2), RXRA(2), RXRG(2), THRA(3), THRB(2)	56476040	120	96	119	42	29	19	22	21	29	0	0.864	1.000	1.000
467	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(3), AKR1B10(1), B4GALT1(3), G6PC(2), G6PC2(3), GAA(2), GALE(1), GALK2(4), GALT(2), GANC(4), GCK(3), GLA(5), GLB1(4), HK1(3), HK2(5), HK3(5), HSD3B7(1), LALBA(1), LCT(17), MGAM(22), PFKL(1), PFKM(8), PFKP(7), PGM1(5), PGM3(2), RDH11(4), RDH12(2), RDH13(2), RDH14(2), UGP2(4)	54171946	128	95	125	35	15	27	27	41	18	0	0.319	1.000	1.000
468	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(1), ACAA2(2), ACADL(1), ACADS(2), ACADSB(4), ACADVL(5), ACAT1(3), ACOX1(4), ACOX3(5), ACSL1(3), ACSL3(3), ACSL4(5), ACSL5(5), ACSL6(4), ADH1A(1), ADH1C(4), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), CPT1A(6), CPT1B(4), CPT1C(7), CPT2(5), CYP4A11(8), CYP4A22(2), EHHADH(4), GCDH(2), HADH(2), HADHA(3), HADHB(3), HSD17B10(1), HSD17B4(8)	70206659	137	95	136	33	25	35	34	28	14	1	0.139	1.000	1.000
469	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(6), AKT1(2), AKT2(5), AKT3(4), DAG1(2), GNAQ(1), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), PDK1(2), PHKA2(13), PIK3CB(8), PITX2(5), PLD1(7), PLD2(2), PLD3(2), VN1R1(1)	63170641	133	95	132	34	22	39	14	36	22	0	0.228	1.000	1.000
470	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ABP1(1), ACAT1(3), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), AOC2(6), AOC3(3), AOX1(7), ASMT(1), CAT(2), CYP1A1(1), CYP1A2(2), CYP2A13(8), CYP2A6(1), CYP2A7(1), CYP2B6(5), CYP2C18(2), CYP2C19(6), CYP2C8(3), CYP2C9(3), CYP2D6(3), CYP2E1(2), CYP2F1(5), CYP3A4(4), CYP3A5(2), CYP3A7(5), CYP4B1(4), CYP4F8(1), CYP51A1(2), DDC(4), EHHADH(4), GCDH(2), HAAO(2), HADHA(3), KMO(8), KYNU(3), MAOA(2), MAOB(4), TDO2(2), TPH1(3), WARS2(2)	78967109	145	93	144	54	18	40	26	37	23	1	0.927	1.000	1.000
471	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(4), CDC7(2), CDK2(2), CDT1(2), DIAPH2(9), GMNN(2), MCM10(7), MCM2(5), MCM3(4), MCM4(5), MCM5(3), MCM6(4), MCM7(7), NACA(8), POLA2(6), POLD1(5), POLD2(1), POLE(10), POLE2(2), PRIM1(1), RFC1(7), RFC2(1), RFC4(3), RFC5(1), RPA1(1), RPA2(2), RPA3(2), RPA4(3), UBA52(2), UBC(13)	72199391	124	90	123	35	15	40	19	27	22	1	0.752	1.000	1.000
472	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(5), CALM2(2), CREB1(2), ELK1(4), FOS(1), GNAI1(2), GNAQ(1), GNAS(11), GNB1(2), HRAS(2), JUN(3), MAP2K1(5), MAPK3(1), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(1), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKCA(4), RAF1(4), RPS6KA3(8), SYT1(2)	47297656	117	90	117	32	27	27	19	23	21	0	0.422	1.000	1.000
473	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(2), AKT2(5), AKT3(4), ANKRD6(5), APC(23), AXIN1(5), AXIN2(5), CER1(2), CSNK1A1(4), CTNNB1(2), DACT1(2), DKK2(1), DKK3(4), DKK4(3), DVL1(2), FSTL1(1), GSK3A(5), GSK3B(2), LRP1(28), MVP(2), NKD1(1), NKD2(2), PSEN1(2), PTPRA(6), SENP2(1), SFRP1(3), WIF1(3)	56778961	125	89	125	38	25	32	17	26	22	3	0.760	1.000	1.000
474	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(7), ACAA1(1), ACAA2(2), ACADS(2), ACAT1(3), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH6A1(1), ALDH9A1(1), AOX1(7), AUH(1), BCAT1(4), BCAT2(5), BCKDHA(4), BCKDHB(1), DBT(1), DLD(1), EHHADH(4), HADH(2), HADHA(3), HADHB(3), HIBADH(2), HIBCH(2), HMGCS1(6), HMGCS2(3), HSD17B10(1), HSD17B4(8), IVD(3), MCCC1(4), MCCC2(1), MUT(3), OXCT1(5), OXCT2(5), PCCA(4), PCCB(2)	62197409	118	88	115	27	21	34	19	24	20	0	0.193	1.000	1.000
475	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(2), ALG10(3), ALG10B(6), ALG11(1), ALG12(3), ALG13(5), ALG14(1), ALG2(2), ALG3(1), ALG5(5), ALG6(2), ALG8(2), ALG9(2), B4GALT1(3), B4GALT3(2), DAD1(1), DDOST(2), DHDDS(5), DOLPP1(2), DPAGT1(4), DPM1(4), FUT8(2), GANAB(10), MAN1A1(6), MAN1A2(3), MAN1B1(3), MAN2A1(6), MGAT3(4), MGAT4A(4), MGAT4B(5), MGAT5(3), MGAT5B(8), RPN1(4), RPN2(2), ST6GAL1(3), STT3B(3)	59247143	124	87	124	30	13	34	34	25	17	1	0.243	1.000	1.000
476	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(2), APC(23), ASAH1(1), DAG1(2), DLG4(1), EPHB2(5), GNAI1(2), GNAQ(1), ITPR1(15), ITPR2(18), ITPR3(14), KCNJ3(2), KCNJ5(1), KCNJ9(1), MAPK1(1), PITX2(5), PTX3(1), RHO(2), RYR1(29)	65501142	126	87	125	47	27	28	16	40	14	1	0.918	1.000	1.000
477	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(1), AGXT(1), AGXT2(2), AKR1B10(1), ALAS1(6), ALAS2(8), AMT(1), AOC2(6), AOC3(3), BHMT(1), CBS(1), CHKA(1), CHKB(5), CTH(3), DAO(1), DLD(1), DMGDH(7), GAMT(1), GARS(2), GATM(3), GCAT(4), GLDC(8), HSD3B7(1), MAOA(2), MAOB(4), PEMT(1), PHGDH(1), PIPOX(2), PISD(1), PSAT1(1), PSPH(1), RDH11(4), RDH12(2), RDH13(2), RDH14(2), SARDH(4), SARS(4), SHMT1(1), SHMT2(4), TARS(8), TARS2(11)	61019753	123	86	123	38	14	29	23	37	20	0	0.572	1.000	1.000
478	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(1), AGMAT(4), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH4A1(3), ALDH9A1(1), AMD1(2), AOC2(6), AOC3(3), ARG1(3), ARG2(2), ASL(4), CKB(1), CKM(1), CKMT1A(1), CKMT1B(1), CKMT2(5), CPS1(12), DAO(1), GAMT(1), GATM(3), GLUD1(2), GOT1(2), GOT2(1), MAOA(2), MAOB(4), NOS1(13), NOS3(3), OAT(2), OTC(3), P4HA1(3), P4HA2(5), P4HA3(4), P4HB(2), PYCR1(1), RARS(5)	62223883	128	85	127	38	24	31	39	21	13	0	0.435	1.000	1.000
479	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(3), AGTR2(2), CALM2(2), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CDK5(2), F2(2), GNA11(4), GNAI1(2), GNB1(2), HRAS(2), JAK2(7), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK14(2), MAPK3(1), MAPK8(2), MAPT(4), MYLK(11), PLCG1(8), PRKCA(4), PTK2B(7), RAF1(4), SHC1(2), SOS1(5), STAT1(4), STAT3(5), STAT5A(6), SYT1(2)	59850132	116	85	116	34	21	31	18	25	21	0	0.525	1.000	1.000
480	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(1), AGXT(1), AGXT2(2), ALAS1(6), ALAS2(8), AMT(1), AOC2(6), AOC3(3), ATP6V0C(1), BHMT(1), CBS(1), CHKA(1), CHKB(5), CPT1B(4), CTH(3), DAO(1), DLD(1), DMGDH(7), GAMT(1), GARS(2), GATM(3), GCAT(4), GLDC(8), MAOA(2), MAOB(4), PEMT(1), PISD(1), PLCB2(7), PLCG1(8), PLCG2(8), PSPH(1), SARDH(4), SARS(4), SHMT1(1), SHMT2(4), TARS(8)	59848972	124	85	124	45	19	23	22	34	25	1	0.892	1.000	1.000
481	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	28	ARSB(3), FUCA1(1), FUCA2(3), GALNS(2), GBA(2), GLB1(4), GNS(3), GUSB(6), HEXA(3), HEXB(3), HGSNAT(6), HPSE(6), HPSE2(5), HYAL2(3), IDS(3), IDUA(1), LCT(17), MAN2B1(6), MAN2B2(9), MAN2C1(6), MANBA(5), NAGLU(2), NEU1(1), NEU3(2), SPAM1(4)	46796057	106	85	107	30	20	31	16	22	17	0	0.420	1.000	1.000
482	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	38	ANAPC1(11), ANAPC10(1), ANAPC11(1), ANAPC4(4), ANAPC5(5), ANAPC7(5), BTRC(4), CDC16(3), CDC20(1), CDC23(2), CUL1(2), CUL2(4), CUL3(5), FBXW7(15), ITCH(4), SKP1(1), SKP2(2), SMURF1(3), SMURF2(5), TCEB1(1), UBA1(8), UBE2C(1), UBE2D1(1), UBE2D2(3), UBE2D3(2), UBE2E1(1), UBE2E3(1), WWP1(6), WWP2(12)	55872327	114	85	109	23	19	41	16	22	15	1	0.162	1.000	1.000
483	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(3), B4GALT1(3), G6PC(2), GAA(2), GALE(1), GALK2(4), GALT(2), GANAB(10), GCK(3), GLA(5), GLB1(4), HK1(3), HK2(5), HK3(5), LALBA(1), LCT(17), MGAM(22), PFKM(8), PFKP(7), PGM1(5), PGM3(2)	45975652	114	84	111	32	15	23	27	34	15	0	0.386	1.000	1.000
484	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(8), ACTG2(4), ADCY3(5), ADCY9(14), AK1(1), ARF1(2), ATP6V0A1(6), ATP6V0A2(3), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V0D2(2), ATP6V0E1(2), ATP6V1A(4), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1E2(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), ERO1L(3), GNAS(11), PDIA4(7), PLCG1(8), PLCG2(8), PRKCA(4), SEC61A1(4), SEC61A2(4), TRIM23(4)	52958639	124	84	123	30	23	37	19	21	24	0	0.203	1.000	1.000
485	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	58	A4GALT(1), B3GALNT1(2), B3GALT1(3), B3GALT2(2), B3GALT4(2), B3GALT5(2), B3GNT1(1), B3GNT2(2), B3GNT3(1), B3GNT4(1), B3GNT5(4), B4GALNT1(1), B4GALT1(3), B4GALT3(2), B4GALT4(2), B4GALT6(2), FUT1(1), FUT3(3), FUT5(2), FUT6(3), GBGT1(2), GCNT2(1), PIGA(5), PIGB(2), PIGG(7), PIGL(2), PIGM(3), PIGN(4), PIGO(3), PIGQ(4), PIGS(2), PIGT(5), PIGV(2), PIGZ(3), ST3GAL1(2), ST3GAL2(2), ST3GAL3(5), ST3GAL4(2), ST3GAL5(2), ST3GAL6(1), ST6GALNAC3(4), ST6GALNAC4(1), ST6GALNAC5(2), ST6GALNAC6(4), ST8SIA1(1), UGCG(1)	66934964	112	83	112	29	18	28	28	22	16	0	0.198	1.000	1.000
486	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS1(6), ALAS2(8), BLVRA(4), BLVRB(1), COX10(7), COX15(3), CP(8), EARS2(3), EPRS(11), FTMT(2), GUSB(6), HCCS(1), HMBS(3), HMOX2(1), MMAB(1), PPOX(6), UGT1A1(4), UGT1A10(3), UGT1A3(3), UGT1A4(4), UGT1A6(2), UGT1A7(3), UGT1A8(2), UGT1A9(2), UGT2A1(7), UGT2B10(3), UGT2B11(1), UGT2B15(5), UGT2B17(2), UGT2B28(3), UGT2B4(3), UGT2B7(3), UROD(2), UROS(2)	59732475	125	82	124	42	9	36	24	38	17	1	0.884	1.000	1.000
487	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), DAG1(2), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), NFAT5(7), PDE6A(7), PDE6B(3), PDE6C(6), SLC6A13(4), TF(5)	51432746	103	82	102	36	14	31	14	30	14	0	0.844	1.000	1.000
488	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	41	ACACA(13), ACACB(13), ACAT1(3), ACOT12(1), ACSS1(1), ACSS2(2), ACYP1(2), AKR1B1(3), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), DLAT(2), DLD(1), GRHPR(3), HAGH(1), LDHA(3), LDHC(4), LDHD(1), MDH1(1), ME2(2), ME3(4), PC(10), PCK1(5), PCK2(4), PDHA1(2), PDHA2(4), PDHB(1), PKLR(5)	65943923	108	81	107	30	25	28	21	21	13	0	0.313	1.000	1.000
489	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(3), CAPN1(8), CAPN2(8), CXCR3(6), EGF(5), EGFR(5), HRAS(2), ITGA1(6), ITGB1(5), MAPK1(1), MAPK3(1), MYLK(11), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PTK2(7), TLN1(16)	47753526	99	79	98	32	20	22	22	19	15	1	0.666	1.000	1.000
490	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(6), AASDHPPT(4), AASS(5), ACAT1(3), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), ATP6V0C(1), BBOX1(2), DLST(3), DOT1L(10), EHHADH(4), EHMT1(9), EHMT2(6), GCDH(2), HADHA(3), PLOD1(2), PLOD2(2), PLOD3(9), SHMT1(1), SHMT2(4), TMLHE(1)	49117614	99	78	97	33	12	21	28	18	20	0	0.833	1.000	1.000
491	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(3), ATP4B(3), ATP5O(2), ATP6AP1(2), ATP6V0A1(6), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), ATP7A(13), ATP7B(6), COX10(7), COX5A(1), COX5B(1), COX6A1(1), COX6C(1), COX7A2(2), NDUFA1(2), NDUFA10(1), NDUFA4(1), NDUFB5(4), NDUFB6(2), NDUFS1(1), NDUFS2(7), NDUFV1(5), NDUFV2(1), PPA2(2), SDHB(2), SHMT1(1), UQCRB(1), UQCRC1(1), UQCRFS1(1)	55684794	111	76	111	36	21	35	16	23	16	0	0.706	1.000	1.000
492	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	DPM2(1), EGFR(5), ELK1(4), GNAS(11), GNB1(2), HRAS(2), IGF1R(7), ITGB1(5), KLK2(3), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), MKNK1(2), MKNK2(4), MYC(1), NGFR(1), PDGFRA(6), PPP2CA(3), PTPRR(4), RAF1(4), RPS6KA1(7), RPS6KA5(4), SHC1(2), SOS1(5), SRC(1), STAT3(5)	46574076	98	75	96	25	20	26	12	27	13	0	0.378	1.000	1.000
493	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	35	ARSA(2), ARSE(4), ASAH1(1), B4GALT6(2), CERK(2), DEGS1(4), DEGS2(1), ENPP7(5), GAL3ST1(5), GALC(1), GBA(2), GLA(5), GLB1(4), LCT(17), NEU1(1), NEU3(2), PPAP2A(2), PPAP2C(1), SGMS1(2), SGMS2(2), SGPP1(2), SGPP2(1), SMPD1(2), SMPD2(2), SMPD3(1), SMPD4(4), SPHK1(1), SPHK2(3), SPTLC1(4), SPTLC2(6), UGCG(1), UGT8(5)	47091390	97	75	95	26	20	28	15	23	11	0	0.304	1.000	1.000
494	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B4GALT5(4), C1GALT1(3), C1GALT1C1(3), GALNT1(3), GALNT10(5), GALNT11(5), GALNT12(2), GALNT13(6), GALNT14(1), GALNT2(2), GALNT3(3), GALNT4(1), GALNT5(6), GALNT6(3), GALNT7(5), GALNT8(6), GALNT9(6), GALNTL1(3), GALNTL2(2), GALNTL4(1), GALNTL5(7), GCNT3(1), GCNT4(3), OGT(5), ST3GAL1(2), ST3GAL2(2), ST6GALNAC1(6), WBSCR17(7)	46701401	103	73	103	38	18	24	16	28	14	3	0.921	1.000	1.000
495	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(23), ATF2(4), AXIN1(5), BMP10(1), BMP2(3), BMP4(2), BMP5(4), BMPR1A(1), BMPR2(8), CHRD(5), CTNNB1(2), DVL1(2), FZD1(3), GATA4(2), GSK3B(2), MAP3K7(3), MEF2C(4), NKX2-5(1), NOG(1), NPPA(1), RFC1(7), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TGFBR2(4), TGFBR3(4)	50555577	100	72	99	32	14	26	13	29	16	2	0.838	1.000	1.000
496	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(3), AKR1B10(1), ALDOA(5), ALDOB(3), ALDOC(2), FBP1(2), FPGT(1), FUK(4), GMDS(2), GMPPA(1), HK1(3), HK2(5), HK3(5), HSD3B7(1), KHK(4), MPI(2), MTMR1(1), MTMR2(2), MTMR6(3), PFKFB2(1), PFKFB3(4), PFKFB4(3), PFKL(1), PFKM(8), PFKP(7), PGM2(5), PMM1(2), RDH11(4), RDH12(2), RDH13(2), RDH14(2), SORD(2), TPI1(2), TSTA3(2)	53022759	97	71	95	27	15	20	14	29	19	0	0.431	1.000	1.000
497	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(5), ADRBK2(1), ARRB2(1), CALM2(2), CALML6(1), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CLCA1(6), CLCA2(5), CLCA4(4), CNGA3(4), CNGA4(5), CNGB1(4), GUCA1A(1), GUCA1B(1), GUCA1C(4), PDC(1), PDE1C(5), PRKACA(4), PRKACB(1), PRKACG(3), PRKG1(5), PRKG2(8), PRKX(5)	44104497	89	70	88	42	13	21	16	25	14	0	0.996	1.000	1.000
498	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	36	ACACA(13), ACAT1(3), ACYP1(2), ADH5(5), AKR1B1(3), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), DLAT(2), DLD(1), GRHPR(3), HAGH(1), LDHA(3), LDHC(4), LDHD(1), MDH1(1), ME2(2), ME3(4), PC(10), PCK1(5), PDHA1(2), PDHA2(4), PDHB(1), PKLR(5)	51950911	97	70	96	27	21	28	19	16	13	0	0.369	1.000	1.000
499	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(3), BAD(1), BRAF(5), CREB1(2), CREB3(1), CREB5(4), DUSP4(1), DUSP6(1), DUSP9(2), EEF2K(6), MAP2K1(5), MAP2K2(2), MAP3K8(4), MAPK1(1), MAPK3(1), MKNK1(2), MKNK2(4), MOS(3), NFKB1(5), RAP1A(2), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), SHC1(2), SOS1(5), SOS2(6), TRAF3(3)	42224949	91	70	90	23	17	22	10	20	21	1	0.380	1.000	1.000
500	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(3), ACTN1(6), ACTN2(10), ACTN3(7), CAPN1(8), ITGA1(6), ITGB1(5), ITGB3(4), PTK2(7), SPTAN1(13), SRC(1), TLN1(16)	41376609	86	70	86	30	19	20	15	17	14	1	0.873	1.000	1.000
501	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	38	ARNTL(2), AZIN1(3), CBX3(2), CLOCK(3), CRY1(2), CRY2(3), DNAJA1(2), EIF4G2(2), ETV6(4), GSTP1(1), HSPA8(6), IDI1(7), MYF6(5), NCKAP1(9), NR1D2(2), PER1(10), PER2(8), PPP1R3C(3), PPP2CB(2), SF3A3(1), TOB1(2), TUBB3(2), UCP3(2), UGP2(4), VAPA(2), ZFR(7)	51576361	96	69	96	32	14	39	15	15	12	1	0.917	1.000	1.000
502	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	37	ACAA1(1), ACAA2(2), ACAD8(1), ACAD9(4), ADH1A(1), ADH1C(4), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), AKR1B10(1), AKR1C4(3), AKR1D1(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), BAAT(5), CEL(4), CYP27A1(1), CYP7A1(3), HADHB(3), HSD3B7(1), LIPA(4), RDH11(4), RDH12(2), RDH13(2), RDH14(2), SLC27A5(4), SOAT1(2), SOAT2(2), SRD5A1(4)	44785865	91	68	90	25	16	17	26	16	16	0	0.351	1.000	1.000
503	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	23	POLA1(15), POLA2(6), POLB(1), POLD1(5), POLD2(1), POLE(10), POLE2(2), POLE3(1), POLG(7), POLG2(2), POLH(3), POLI(2), POLK(2), POLL(3), POLM(4), POLQ(12), PRIM1(1), REV1(6), REV3L(17), RFC5(1)	58314418	101	68	99	24	10	25	22	25	18	1	0.457	1.000	1.000
504	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM2(2), DLG4(1), GRIN1(3), GRIN2A(16), GRIN2B(11), GRIN2C(5), GRIN2D(5), NOS1(13), PPP3CA(5), PPP3CB(3), PPP3CC(1), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKCA(4), SYT1(2)	36099627	86	68	86	31	18	20	21	15	12	0	0.711	1.000	1.000
505	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(7), ACACA(13), ACACB(13), ACAT1(3), ACSS1(1), ACSS2(2), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH6A1(1), ALDH9A1(1), EHHADH(4), HADHA(3), HIBCH(2), LDHA(3), LDHC(4), MLYCD(4), MUT(3), PCCA(4), PCCB(2), SUCLA2(1), SUCLG2(1)	57129081	88	67	87	28	9	28	18	20	13	0	0.695	1.000	1.000
506	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(2), AP2A1(6), AP2M1(4), ARF1(2), BAD(1), BTK(7), EEA1(10), GRASP(2), GSK3A(5), GSK3B(2), LYN(6), PDPK1(2), PFKL(1), PFKM(8), PFKP(7), PLCG1(8), PRKCE(8), PRKCZ(2), RPS6KB1(4), VAV2(3)	35572963	90	67	88	32	17	19	14	23	17	0	0.902	1.000	1.000
507	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(23), AXIN1(5), CREBBP(15), CTNNB1(2), DVL1(2), EP300(13), FZD1(3), GSK3B(2), HDAC1(5), LDB1(1), PITX2(5), TRRAP(18)	46527569	94	66	94	28	15	19	13	28	17	2	0.720	1.000	1.000
508	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(9), CARS(5), DARS(4), EPRS(11), FARS2(4), GARS(2), HARS(1), IARS(8), LARS(5), LARS2(3), MARS(11), MARS2(1), NARS(1), QARS(10), RARS(5), SARS(4), TARS(8), WARS2(2), YARS(4)	46204518	98	64	97	24	11	35	14	23	15	0	0.306	1.000	1.000
509	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(5), CD3E(3), CD3G(3), CD4(4), CREBBP(15), GNAS(11), GNB1(2), HLA-DRB1(10), LCK(2), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PTPRC(8), ZAP70(3)	30931583	81	64	81	27	16	17	17	14	17	0	0.787	1.000	1.000
510	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(5), CD3E(3), CD3G(3), CD4(4), CREBBP(15), GNAS(11), GNB1(2), HLA-DRB1(10), LCK(2), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PTPRC(8), ZAP70(3)	30931583	81	64	81	27	16	17	17	14	17	0	0.787	1.000	1.000
511	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(23), AXIN1(5), BTRC(4), CCND1(1), CREBBP(15), CSNK1A1(4), CSNK2A1(3), CTBP1(1), CTNNB1(2), DVL1(2), FZD1(3), GSK3B(2), HDAC1(5), MAP3K7(3), MYC(1), NLK(1), PPARD(2), PPP2CA(3), TLE1(4), WIF1(3)	41357440	87	63	87	27	18	25	10	19	13	2	0.806	1.000	1.000
512	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(1), ACAA2(2), ACADL(1), ACADS(2), ACADSB(4), ACAT1(3), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH6A1(1), ALDH9A1(1), AOX1(7), BCAT1(4), BCKDHA(4), BCKDHB(1), EHHADH(4), HADHA(3), HADHB(3), HIBADH(2), IVD(3), MCCC1(4), MCCC2(1), MUT(3), OXCT1(5), PCCA(4), PCCB(2)	51861515	86	62	85	22	14	22	15	19	16	0	0.413	1.000	1.000
513	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	28	AKR1C4(3), AKR1D1(1), ARSB(3), ARSE(4), CYP11B1(5), CYP11B2(4), HSD11B1(3), HSD11B2(2), HSD17B2(4), HSD17B3(2), HSD3B1(3), HSD3B2(4), SRD5A1(4), STS(1), SULT1E1(4), UGT1A1(4), UGT1A10(3), UGT1A3(3), UGT1A4(4), UGT1A6(2), UGT1A7(3), UGT1A8(2), UGT1A9(2), UGT2B15(5), UGT2B4(3)	38118021	78	60	77	26	8	22	20	20	8	0	0.619	1.000	1.000
514	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(7), ACACA(13), ACADL(1), ACADSB(4), ACAT1(3), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH6A1(1), ALDH9A1(1), EHHADH(4), HADHA(3), LDHA(3), LDHC(4), MLYCD(4), MUT(3), PCCA(4), PCCB(2), SUCLA2(1), SUCLG2(1)	47737000	80	60	79	27	7	28	15	17	13	0	0.829	1.000	1.000
515	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(8), C5(5), C6(8), C7(8), ICAM1(2), IL1A(1), IL6(2), IL8(1), ITGA4(6), ITGAL(5), ITGB1(5), ITGB2(8), SELP(11), SELPLG(2), VCAM1(7)	35558244	79	59	79	27	9	22	18	22	8	0	0.805	1.000	1.000
516	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(2), CDK7(3), ERCC3(5), GTF2E1(2), GTF2E2(3), GTF2F2(1), GTF2H1(2), ILK(3), MNAT1(2), POLR1A(10), POLR1B(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2F(5), POLR2G(1), POLR2H(1), POLR2J(1), POLR3B(2), POLR3D(2), POLR3E(4), POLR3H(1), POLR3K(1), TAF13(1), TAF5(4), TAF6(3), TAF7(1), TAF9(2), TBP(2)	49360508	80	59	79	30	10	20	12	18	20	0	0.956	1.000	1.000
517	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(7), ABP1(1), ACADL(1), ACADSB(4), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), AOC2(6), AOC3(3), CNDP1(7), DPYD(2), DPYS(3), EHHADH(4), GAD1(3), GAD2(3), HADHA(3), MLYCD(4), UPB1(3)	41022518	76	58	75	28	10	20	18	15	13	0	0.865	1.000	1.000
518	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP2(2), ACP5(3), ACPP(6), ACPT(1), ALPL(1), ALPP(3), ALPPL2(2), CYP1A1(1), CYP1A2(2), CYP2A13(8), CYP2A6(1), CYP2A7(1), CYP2B6(5), CYP2C18(2), CYP2C19(6), CYP2C8(3), CYP2C9(3), CYP2D6(3), CYP2E1(2), CYP2F1(5), CYP3A4(4), CYP3A5(2), CYP3A7(5), CYP4B1(4), CYP4F8(1), CYP51A1(2), PON1(4)	41404914	82	58	81	26	12	20	15	25	10	0	0.536	1.000	1.000
519	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(7), ABP1(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), AOC2(6), AOC3(3), CNDP1(7), DPYD(2), DPYS(3), EHHADH(4), GAD1(3), GAD2(3), HADHA(3), HIBCH(2), MLYCD(4), SRM(4), UPB1(3)	37855468	72	58	71	22	9	17	19	14	13	0	0.602	1.000	1.000
520	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA1A(6), ADRA1B(1), ADRA2C(2), ADRB2(2), ADRB3(1), CHRM1(4), CHRM2(6), CHRM3(3), CHRM4(1), DRD1(1), DRD2(3), DRD3(1), DRD5(4), HRH1(4), HRH2(4), HTR1A(4), HTR1B(3), HTR1D(4), HTR1E(4), HTR1F(4), HTR2A(5), HTR2C(6), HTR5A(4)	35139381	77	58	77	32	25	11	11	20	10	0	0.703	1.000	1.000
521	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(11), APOA1(3), APOA4(1), CETP(3), CYP7A1(3), DGAT1(2), HMGCR(5), LCAT(1), LDLR(6), LIPC(2), LPL(1), LRP1(28), SCARB1(5), SOAT1(2)	38168040	73	57	73	24	18	10	20	14	10	1	0.715	1.000	1.000
522	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CALM2(2), CDKN1A(1), GNAQ(1), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(1), PRKCA(4), SP1(6), SP3(7), SYT1(2)	28015703	66	56	65	19	7	17	11	17	14	0	0.635	1.000	1.000
523	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRA(4), BLVRB(1), CP(8), EPRS(11), GUSB(6), HCCS(1), HMBS(3), HMOX2(1), PPOX(6), UGT1A1(4), UGT1A10(3), UGT1A3(3), UGT1A4(4), UGT1A6(2), UGT1A7(3), UGT1A8(2), UGT1A9(2), UGT2B15(5), UGT2B4(3), UROD(2), UROS(2)	39399533	76	56	75	30	5	22	17	22	9	1	0.952	1.000	1.000
524	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(7), DLG4(1), EPHB2(5), F2(2), F2RL1(1), F2RL2(2), JUN(3), MAP2K5(1), MAPK1(1), MAPK7(4), MAPK8(2), MYEF2(3), PLD1(7), PLD2(2), PLD3(2), PTK2(7), RAF1(4), RASAL1(5), SRC(1), TEC(6), VAV1(6)	39214541	72	56	72	21	20	19	12	12	9	0	0.441	1.000	1.000
525	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(4), ABAT(7), ACADS(2), ACAT1(3), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH5A1(2), ALDH9A1(1), EHHADH(4), GAD1(3), GAD2(3), HADHA(3), L2HGDH(2), OXCT1(5), PDHA1(2), PDHA2(4), PDHB(1), SDHB(2)	36716133	69	55	68	22	13	17	14	15	10	0	0.632	1.000	1.000
526	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	25	ABP1(1), ALDH1A3(7), ALDH3A1(3), ALDH3B2(4), AOC2(6), AOC3(3), DDC(4), EPX(4), ESCO1(4), ESCO2(1), GOT1(2), GOT2(1), HPD(4), LPO(4), MAOA(2), MAOB(4), MPO(5), PNPLA3(3), SH3GLB1(2), TAT(3), TPO(8)	47296678	75	55	74	21	17	16	11	16	14	1	0.532	1.000	1.000
527	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(1), ALOX15(4), ALOX5(3), CYP1A2(2), CYP2C18(2), CYP2C19(6), CYP2C8(3), CYP2C9(3), CYP2E1(2), CYP3A4(4), CYP3A43(3), CYP3A5(2), CYP3A7(5), HSD3B7(1), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), RDH11(4), RDH12(2), RDH13(2), RDH14(2)	34366289	70	55	70	20	8	20	15	18	9	0	0.453	1.000	1.000
528	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(8), CALM2(2), CAPN2(8), EP300(13), HDAC1(5), HDAC2(2), MEF2D(3), NFATC1(5), NFATC2(4), PPP3CA(5), PPP3CB(3), PPP3CC(1), PRKCA(4), SYT1(2)	33472411	65	55	65	23	8	15	12	15	15	0	0.905	1.000	1.000
529	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(9), AP2A1(6), AP2M1(4), BIN1(2), CALM2(2), DNM1(6), EPN1(4), EPS15(6), PICALM(3), PPP3CA(5), PPP3CB(3), PPP3CC(1), SYNJ1(4), SYNJ2(4), SYT1(2)	32273756	61	55	61	18	9	15	16	11	10	0	0.572	1.000	1.000
530	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(7), EXT2(6), EXTL1(1), EXTL2(1), EXTL3(6), GLCE(4), HS2ST1(3), HS3ST1(2), HS3ST2(4), HS3ST3A1(1), HS3ST3B1(1), HS3ST5(5), HS6ST1(5), HS6ST2(7), HS6ST3(3), NDST1(4), NDST2(1), NDST3(5)	29006389	66	54	64	21	15	17	4	17	13	0	0.757	1.000	1.000
531	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	12	ACTN1(6), ACTN2(10), ACTN3(7), BCAR1(6), CTNNA1(7), CTNNA2(14), CTNNB1(2), PTK2(7), SRC(1), VCL(6)	27042218	66	53	65	25	17	14	6	13	15	1	0.899	1.000	1.000
532	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(8), CD2(4), CD33(2), CD5(3), CD7(1), IFNA1(1), IFNG(2), IL12B(2), IL3(1), IL4(1), ITGAX(10), TLR2(3), TLR4(15), TLR7(9), TLR9(2)	26556607	64	53	63	22	7	15	17	14	11	0	0.710	1.000	1.000
533	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(9), COL4A2(9), COL4A3(6), COL4A4(9), COL4A5(12), COL4A6(10), P4HB(2), SLC23A1(2), SLC23A2(8), SLC2A3(3)	37226074	70	52	70	26	12	16	18	11	13	0	0.853	1.000	1.000
534	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	26	ACAA1(1), ACAA2(2), ADH1A(1), ADH1C(4), ADH4(1), ADH6(2), ADH7(3), ADHFE1(2), AKR1C4(3), AKR1D1(1), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), BAAT(5), CEL(4), CYP27A1(1), CYP7A1(3), HADHB(3), SOAT2(2), SRD5A1(4)	32736870	64	51	63	24	13	11	20	8	12	0	0.831	1.000	1.000
535	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT3(2), AGPAT4(2), AGPAT6(3), AGPS(1), CHPT1(4), ENPP2(12), ENPP6(2), PAFAH1B1(3), PAFAH1B3(1), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLD1(7), PLD2(2), PPAP2A(2), PPAP2C(1)	33162628	62	51	62	17	6	19	14	14	9	0	0.423	1.000	1.000
536	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	66	MRPL13(2), MRPS7(3), RPL10L(1), RPL12(1), RPL13A(4), RPL18(1), RPL18A(4), RPL19(2), RPL22L1(1), RPL24(1), RPL26(1), RPL3(4), RPL31(1), RPL32(1), RPL35(1), RPL36A(2), RPL37A(1), RPL3L(3), RPL41(1), RPL7(1), RPL8(2), RPL9(1), RPS10(1), RPS12(1), RPS16(1), RPS18(1), RPS2(1), RPS25(1), RPS27(1), RPS29(1), RPS5(6), RPS6(4), RPS8(1), RPS9(2)	32146887	60	51	60	16	13	15	12	13	7	0	0.498	1.000	1.000
537	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(4), AGT(3), AGTR1(4), AGTR2(2), COL4A1(9), COL4A2(9), COL4A3(6), COL4A4(9), COL4A5(12), COL4A6(10), REN(1)	37339412	69	50	69	22	12	16	16	13	12	0	0.590	1.000	1.000
538	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(7), AGT(3), AGTR2(2), EDN1(5), EDNRA(3), EDNRB(2), EGF(5), EGFR(5), FOS(1), HRAS(2), JUN(3), MYC(1), NFKB1(5), PLCG1(8), PRKCA(4), RELA(3)	29202165	59	50	58	19	10	15	7	16	11	0	0.734	1.000	1.000
539	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(4), EGF(5), EGFR(5), HRAS(2), MAP2K1(5), MAPK1(1), MAPK3(1), PTPRB(12), RAF1(4), RASA1(2), SHC1(2), SOS1(5), SPRY1(7), SPRY2(2), SPRY3(6), SRC(1)	36090969	64	50	63	26	14	14	9	18	9	0	0.916	1.000	1.000
540	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM2(2), CAMK1(1), CAMK1G(5), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CAMK4(5), HDAC5(6), MEF2A(6), MEF2C(4), MEF2D(3), PPARA(4), PPP3CA(5), PPP3CB(3), PPP3CC(1), SLC2A4(3), SYT1(2)	29818299	63	49	63	19	4	17	10	20	12	0	0.625	1.000	1.000
541	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(5), CREB1(2), CREBBP(15), EP300(13), NCOA3(9), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), RARA(1), RXRA(2)	29299005	62	47	62	18	11	15	11	11	14	0	0.650	1.000	1.000
542	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(1), C1QB(1), C1R(6), C1S(1), C2(1), C3(8), C5(5), C6(8), C7(8), C8A(2), C9(5), MASP1(8), MASP2(2), MBL2(2)	30324581	58	47	58	19	9	17	14	11	7	0	0.781	1.000	1.000
543	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	23	ABP1(1), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH3B2(4), ALDH9A1(1), AOC2(6), AOC3(3), ASPA(4), CNDP1(7), DDC(4), HAL(7), HARS(1), HNMT(2), MAOA(2), MAOB(4), PRPS2(1)	33799259	68	47	67	22	14	14	15	11	14	0	0.652	1.000	1.000
544	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(24), MAP2(18), PPP2CA(3), PRKACB(1), PRKACG(3), PRKAG1(2), PRKAR2A(3), PRKAR2B(2), PRKCE(8)	26140728	64	46	64	19	7	22	10	13	11	1	0.841	1.000	1.000
545	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(3), GUSB(6), UGDH(1), UGP2(4), UGT1A1(4), UGT1A10(3), UGT1A3(3), UGT1A4(4), UGT1A6(2), UGT1A7(3), UGT1A8(2), UGT1A9(2), UGT2A1(7), UGT2B10(3), UGT2B11(1), UGT2B15(5), UGT2B17(2), UGT2B28(3), UGT2B4(3), UGT2B7(3), XYLB(2)	38200469	66	46	66	28	3	20	10	22	11	0	0.971	1.000	1.000
546	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(12), ABCC2(7), ABCG2(1), BCHE(6), CES1(4), CES2(2), CYP3A4(4), CYP3A5(2), UGT1A1(4), UGT1A10(3), UGT1A3(3), UGT1A4(4), UGT1A6(2), UGT1A7(3), UGT1A8(2), UGT1A9(2)	33175893	61	46	61	24	6	13	14	21	7	0	0.848	1.000	1.000
547	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	10	CD44(4), ICAM1(2), ITGA4(6), ITGAL(5), ITGAM(6), ITGB1(5), ITGB2(8), SELE(2), SELL(6), SELP(11)	23557680	55	46	55	18	7	12	12	14	10	0	0.746	1.000	1.000
548	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	9	CR1(14), CR2(5), HLA-DRB1(10), ICAM1(2), ITGAL(5), ITGB2(8), PTPRC(8)	21066449	52	45	52	22	4	16	14	10	7	1	0.926	1.000	1.000
549	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(3), EPHA4(5), EPHB1(12), ITGA1(6), ITGB1(5), L1CAM(10), LYN(6), RAP1B(1), SELP(11)	22796856	59	45	59	21	15	11	12	17	3	1	0.782	1.000	1.000
550	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(4), F13A1(5), F2(2), F2R(4), FGA(7), FGB(1), FGG(7), PLAT(6), PLAU(4), PLG(7), SERPINB2(1), SERPINE1(5)	19608259	53	45	53	21	5	13	12	13	10	0	0.940	1.000	1.000
551	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(10), AMT(1), ATIC(3), FTCD(2), GART(3), MTHFD1(9), MTHFD1L(5), MTHFR(6), MTHFS(2), MTR(5), SHMT1(1), SHMT2(4), TYMS(1)	27277911	52	45	51	16	5	18	9	6	14	0	0.690	1.000	1.000
552	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(3), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), CYP2C19(6), CYP2C9(3), DHRS2(4), DHRS3(1), DHRS7(4), DHRSX(1), EHHADH(4), ESCO1(4), ESCO2(1), HADHA(3), PNPLA3(3), SH3GLB1(2), YOD1(1)	44002064	57	45	56	14	9	16	10	14	7	1	0.379	1.000	1.000
553	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	22	POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2D(1), POLR2F(5), POLR2G(1), POLR2H(1), POLR2J(1), POLR3A(5), POLR3B(2), POLR3GL(3), POLR3H(1), POLR3K(1)	33332815	53	45	53	24	9	12	7	14	11	0	0.988	1.000	1.000
554	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(1), C1QB(1), C1R(6), C1S(1), C2(1), C3(8), C5(5), C6(8), C7(8), C8A(2), C8B(3), C9(5), MASP1(8)	29488256	57	44	57	18	8	18	14	10	7	0	0.754	1.000	1.000
555	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(4), BCAT2(5), COASY(4), DPYD(2), DPYS(3), ENPP1(7), ENPP3(6), ILVBL(5), PANK1(2), PANK2(1), PANK4(6), UPB1(3), VNN1(3)	24213883	51	44	51	18	10	10	11	11	9	0	0.803	1.000	1.000
556	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(10), AMT(1), ATIC(3), ATP6V0C(1), GART(3), MTHFD1(9), MTHFD1L(5), MTHFR(6), MTHFS(2), MTR(5), SHMT1(1), SHMT2(4), TYMS(1)	25943183	51	44	50	16	4	18	9	6	14	0	0.703	1.000	1.000
557	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(23), AXIN1(5), BTRC(4), CTNNB1(2), DLL1(5), DVL1(2), FZD1(3), GSK3B(2), NOTCH1(8), PSEN1(2)	27683188	56	44	56	20	8	15	11	14	6	2	0.928	1.000	1.000
558	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(3), ACTR2(2), ACTR3(2), ARPC1A(3), ARPC1B(2), ARPC2(5), NCK1(2), NCKAP1(9), NTRK1(8), PIR(2), PSMA7(3), WASF1(6), WASF2(3), WASF3(5), WASL(4)	22171512	59	43	58	15	6	22	14	6	10	1	0.503	1.000	1.000
559	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(5), ALDOB(3), ALDOC(2), FBP1(2), GOT1(2), GOT2(1), GPT(2), GPT2(3), MDH1(1), ME3(4), PGK1(6), PGK2(1), PKLR(5), TKT(3), TKTL1(3), TKTL2(3), TPI1(2)	28478508	48	42	48	16	9	16	9	8	6	0	0.564	1.000	1.000
560	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(9), ABCB11(13), ABCB4(10), ABCC1(12), ABCC3(9), GSTP1(1)	21319735	54	42	54	19	8	14	13	10	9	0	0.621	1.000	1.000
561	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(5), GTF2A1(2), GTF2E1(2), GTF2F1(1), HDAC3(1), NCOA1(5), NCOA2(6), NCOA3(9), NCOR2(8), POLR2A(6), RARA(1), RXRA(2), TBP(2)	35558465	50	41	50	28	5	10	9	13	13	0	0.999	1.000	1.000
562	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(5), ALDOB(3), ALDOC(2), FBP1(2), GOT1(2), GOT2(1), GPT(2), GPT2(3), MDH1(1), ME2(2), ME3(4), PGK1(6), PKLR(5), TKT(3), TPI1(2)	25415479	43	39	43	15	9	16	6	8	4	0	0.584	1.000	1.000
563	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(3), CYP51A1(2), DHCR24(4), DHCR7(1), EBP(1), FDFT1(4), FDPS(5), GGCX(3), GGPS1(2), HMGCR(5), HSD17B7(1), IDI1(7), IDI2(1), LSS(3), NQO1(1), NSDHL(3), PMVK(2), SQLE(2), VKORC1(1)	27365371	51	39	50	20	10	18	5	12	6	0	0.881	1.000	1.000
564	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(3), GALNT10(5), GALNT2(2), GALNT3(3), GALNT4(1), GALNT6(3), GALNT7(5), GALNT8(6), GALNT9(6), ST3GAL1(2), ST3GAL2(2), ST3GAL4(2), WBSCR17(7)	21132495	47	39	47	14	10	6	9	15	6	1	0.613	1.000	1.000
565	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(2), ARFGAP1(3), ARFGAP3(1), ARFGEF2(9), COPA(8), GBF1(8), GPLD1(5), KDELR1(2), KDELR2(2), KDELR3(2)	23442358	42	38	42	12	6	18	6	5	5	2	0.520	1.000	1.000
566	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(4), CSF1R(3), EGF(5), EGFR(5), MET(10), PDGFRA(6), PRKCA(4), SH3GLB1(2), SH3GLB2(1), SH3KBP1(9), SRC(1)	28180489	50	38	49	24	9	13	6	14	8	0	0.987	1.000	1.000
567	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(13), ACACB(13), FASN(14), MCAT(2), OLAH(1), OXSM(3)	21673574	46	38	46	14	7	14	7	9	9	0	0.579	1.000	1.000
568	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(4), BCAT2(5), IARS(8), IARS2(5), ILVBL(5), LARS(5), LARS2(3), PDHA1(2), PDHA2(4), PDHB(1), VARS(2), VARS2(1)	22928506	45	38	45	14	8	13	9	9	6	0	0.656	1.000	1.000
569	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(2), CLOCK(3), CRY1(2), CRY2(3), CSNK1E(4), NPAS2(8), NR1D1(5), PER1(10), PER2(8), PER3(9)	23701460	54	38	53	20	11	14	8	13	8	0	0.921	1.000	1.000
570	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(15), EP300(13), LPL(1), NCOA1(5), NCOA2(6), PPARG(5), RXRA(2)	26452967	47	38	46	17	9	9	8	10	11	0	0.908	1.000	1.000
571	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(1), C1QB(1), C1R(6), C1S(1), C2(1), C3(8), C5(5), C6(8), C7(8), C8A(2), C9(5)	24690044	46	37	46	13	6	15	12	8	5	0	0.639	1.000	1.000
572	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(1), ACAD9(4), ADH1A(1), ADH1C(4), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), DHRS2(4), DHRS3(1), DHRS7(4), DHRSX(1), ESCO1(4), ESCO2(1), PNPLA3(3), SH3GLB1(2)	35822664	43	37	43	10	4	14	11	10	3	1	0.409	1.000	1.000
573	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	CD4(4), CSF1(5), CSF3(2), HLA-DRB1(10), IFNA1(1), IFNG(2), IL11(1), IL12B(2), IL15(3), IL1A(1), IL3(1), IL4(1), IL6(2), IL7(1), IL8(1), LTA(2), TGFB1(2), TGFB2(1), TGFB3(1)	17950081	43	37	43	17	5	8	10	11	9	0	0.894	1.000	1.000
574	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(2), JAK1(11), PTPRU(10), REG1A(1), STAT1(4), STAT2(5), TYK2(8)	17648282	41	37	39	12	7	5	11	9	9	0	0.655	1.000	1.000
575	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(5), GNAS(11), GNB1(2), PPP2CA(3), PRKAA1(3), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKACB(1), PRKACG(3), PRKAG1(2), PRKAG2(2), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2)	21135409	47	36	47	15	12	10	8	8	9	0	0.775	1.000	1.000
576	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(4), GABRA2(3), GABRA3(6), GABRA4(7), GABRA5(4), GABRA6(6), PRKCE(8), SOD1(1)	11331454	39	34	39	16	5	13	9	9	3	0	0.894	1.000	1.000
577	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(3), ACOT11(3), ACYP1(2), DHRS2(4), DHRS3(1), DHRS7(4), DHRSX(1), EHHADH(4), ESCO1(4), ESCO2(1), FN3K(3), GCDH(2), HADHA(3), PNPLA3(3), SH3GLB1(2), YOD1(1)	36893595	41	34	41	13	6	14	5	12	3	1	0.735	1.000	1.000
578	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	8	CD44(4), ICAM1(2), ITGA4(6), ITGAL(5), ITGB1(5), ITGB2(8), SELE(2), SELL(6)	17658423	38	34	38	15	4	9	6	12	7	0	0.890	1.000	1.000
579	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(3), GUSB(6), UCHL3(2), UGDH(1), UGT1A1(4), UGT1A10(3), UGT1A3(3), UGT1A4(4), UGT1A6(2), UGT1A7(3), UGT1A8(2), UGT1A9(2), UGT2B15(5), UGT2B4(3)	25327862	43	34	43	22	2	10	8	17	6	0	0.984	1.000	1.000
580	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(2), DHCR7(1), FDFT1(4), FDPS(5), HMGCR(5), HMGCS1(6), IDI1(7), LSS(3), NSDHL(3), PMVK(2), SQLE(2)	18731033	40	33	39	14	7	14	4	9	6	0	0.796	1.000	1.000
581	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(5), POLD2(1), POLE(10), POLG(7), POLL(3), POLQ(12)	23689146	39	33	38	11	6	8	6	9	9	1	0.689	1.000	1.000
582	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(1), B3GAT2(1), B3GAT3(2), B4GALT7(1), CHPF(2), CHST11(1), CHST3(1), CHST7(1), CHSY1(3), DSE(11), UST(2), XYLT1(4), XYLT2(5)	17147745	35	33	35	16	15	8	3	6	3	0	0.890	1.000	1.000
583	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(4), ACO2(5), AFMID(1), CS(2), GRHPR(3), HAO1(5), HAO2(2), MDH1(1), MTHFD1(9), MTHFD1L(5)	19478363	37	33	37	13	7	15	6	4	5	0	0.603	1.000	1.000
584	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(13), CPT1A(6), LEP(1), LEPR(7), PRKAA1(3), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKAG1(2), PRKAG2(2)	21034208	38	33	38	16	5	10	6	8	9	0	0.956	1.000	1.000
585	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(4), COASY(4), DPYD(2), DPYS(3), ENPP1(7), ENPP3(6), PANK1(2), PANK2(1), PANK4(6), UPB1(3)	19314824	38	33	38	15	6	8	8	9	7	0	0.898	1.000	1.000
586	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(2), ATP6AP1(2), ATP6V0A1(6), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), FDXR(3), SHMT1(1)	23169551	45	33	45	19	8	15	8	5	9	0	0.876	1.000	1.000
587	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM2(2), CCL2(1), CCR5(1), CXCR4(3), FOS(1), GNAQ(1), JUN(3), MAPK14(2), MAPK8(2), PLCG1(8), PRKCA(4), PTK2B(7), SYT1(2)	19426835	37	32	37	11	7	8	6	6	10	0	0.678	1.000	1.000
588	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(4), ACO2(5), CS(2), GRHPR(3), HAO1(5), HAO2(2), MDH1(1), MTHFD1(9), MTHFD1L(5)	18551378	36	32	36	12	7	15	6	3	5	0	0.531	1.000	1.000
589	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(6), LDLR(6), MBTPS1(3), MBTPS2(6), SCAP(2), SREBF1(4), SREBF2(6)	15959746	33	32	33	12	7	7	12	4	3	0	0.608	1.000	1.000
590	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(4), CD28(2), CD3E(3), CD3G(3), CD4(4), ICAM1(2), ITGAL(5), ITGB2(8), PTPRC(8), THY1(1)	16053129	40	32	40	15	3	11	10	8	8	0	0.770	1.000	1.000
591	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(2), ATP6AP1(2), ATP6V0A1(6), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1)	22081292	42	31	42	19	7	15	8	4	8	0	0.921	1.000	1.000
592	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(2), ATP6AP1(2), ATP6V0A1(6), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1)	22081292	42	31	42	19	7	15	8	4	8	0	0.921	1.000	1.000
593	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	7	CD44(4), ICAM1(2), ITGAL(5), ITGAM(6), ITGB2(8), SELE(2), SELL(6)	15567842	33	31	33	12	4	8	6	6	9	0	0.764	1.000	1.000
594	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(2), ATP6AP1(2), ATP6V0A1(6), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1)	22081292	42	31	42	19	7	15	8	4	8	0	0.921	1.000	1.000
595	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(8), C5(5), C6(8), C7(8), C8A(2), C9(5)	18626179	36	30	36	10	4	15	7	8	2	0	0.633	1.000	1.000
596	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM2(2), CAMK1(1), CAMK1G(5), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CAMK4(5), CAMKK1(3), CAMKK2(4), CREB1(2), SYT1(2)	16458973	37	30	37	12	6	9	7	8	7	0	0.736	1.000	1.000
597	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), FDFT1(4), FDPS(5), HMGCR(5), IDI1(7), LSS(3), NQO1(1), NQO2(2), PMVK(2), SQLE(2), VKORC1(1)	15580074	33	29	32	12	7	11	4	7	4	0	0.804	1.000	1.000
598	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(2), CREM(3), FOS(1), JUN(3), MAPK3(1), OPRK1(2), POLR2A(6), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2)	18215527	33	29	33	13	5	7	8	6	7	0	0.869	1.000	1.000
599	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(10), EGF(5), EGFR(5), HGS(6), TF(5), TFRC(2)	18311915	33	28	32	11	6	9	6	6	6	0	0.830	1.000	1.000
600	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(5), ABP1(1), AOC2(6), AOC3(3), CES1(4), DDHD1(4), ESCO1(4), ESCO2(1), LIPA(4), PLA1A(3), PNPLA3(3), PPME1(2), SH3GLB1(2)	35941837	42	28	42	14	5	9	12	11	4	1	0.777	1.000	1.000
601	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	9	CD3E(3), CD3G(3), CD4(4), HLA-DRB1(10), LCK(2), PTPRC(8), ZAP70(3)	12005239	33	28	33	18	2	8	9	7	7	0	0.989	1.000	1.000
602	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(3), CD3E(3), CD3G(3), HLA-A(3), ICAM1(2), ITGAL(5), ITGB2(8), PRF1(2)	11901415	29	27	28	15	4	8	4	9	4	0	0.940	1.000	1.000
603	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(4), EIF2AK4(10), EIF2B5(4), EIF2S1(3), EIF2S2(3), EIF2S3(2), EIF5(2), GSK3B(2)	16390263	30	27	30	12	3	13	5	6	3	0	0.922	1.000	1.000
604	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), EHHADH(4), HADHA(3)	17306805	29	26	28	11	5	5	9	4	6	0	0.816	1.000	1.000
605	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(17), GNA12(2), PRKACB(1), PRKACG(3), PRKAG1(2), PRKAR2A(3), PRKAR2B(2)	14373556	30	25	30	11	3	11	9	6	0	1	0.822	1.000	1.000
606	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	19	B3GNT1(1), B3GNT2(2), B3GNT3(1), B3GNT4(1), B3GNT5(4), B4GALT1(3), B4GALT3(2), B4GALT4(2), FUT1(1), FUT3(3), FUT5(2), FUT6(3), GCNT2(1), ST3GAL6(1), ST8SIA1(1)	20186507	28	25	28	12	6	8	4	7	3	0	0.856	1.000	1.000
607	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2D(1), POLR2F(5), POLR2G(1), POLR2H(1), POLR2J(1), POLRMT(5)	18080986	30	24	30	16	6	8	2	8	6	0	0.990	1.000	1.000
608	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(3), GPI(3), HK1(3), PFKL(1), PGK1(6), PKLR(5), TPI1(2)	12797847	23	22	23	10	2	7	4	5	5	0	0.824	1.000	1.000
609	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ADAM10(3), ANKRD1(2), ATF3(2), CYR61(3), IFNG(2), IFRD1(2), IL18(2), IL1A(1), IL1R1(1), NR4A3(5), WDR1(1)	15390973	24	22	24	12	3	7	5	8	1	0	0.950	1.000	1.000
610	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	9	CCL11(1), CCR3(2), CD4(4), HLA-DRB1(10), IL4(1), IL5RA(4), IL6(2)	6922598	24	22	24	11	1	4	6	6	7	0	0.935	1.000	1.000
611	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(3), ACTR2(2), ACTR3(2), ARPC1A(3), ARPC1B(2), ARPC2(5), WASF1(6), WASL(4)	11850785	27	21	27	12	3	12	6	0	5	1	0.932	1.000	1.000
612	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(5), CYSLTR2(1), GPR161(6), GPR34(4), GPR39(3), GPR45(2), GPR65(1), GPR75(3)	14262818	25	20	25	11	2	4	2	13	4	0	0.894	1.000	1.000
613	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(5), PARK2(3), SNCA(1), SNCAIP(7), UBE2F(1), UBE2L3(1), UBE2L6(2)	9042881	20	19	20	10	3	8	4	4	1	0	0.955	1.000	1.000
614	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(2), DCN(2), FMOD(1), KERA(3), LUM(2)	5254266	10	7	10	7	2	5	2	1	0	0	0.955	1.000	1.000
615	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	6	B3GNT1(1), FUT1(1), GCNT2(1), ST8SIA1(1)	7748235	4	4	4	6	0	1	0	3	0	0	0.998	1.000	1.000
616	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(2), LIPT1(1)	2217960	3	3	3	2	0	2	0	1	0	0	0.946	1.000	1.000