rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(5), GNAS(11), GNB1(2), PRKACA(4), PRKAR1A(6) 8502224 28 26 28 3 9 3 4 5 7 0 0.0943 0.0426 1.000 2 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(3), CD3G(3) 1706454 6 6 6 0 0 2 1 2 1 0 0.271 0.121 1.000 3 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(7), ESR2(5), ITPKA(1), PDE1A(5), PDE1B(5), PLCB1(13), PLCB2(7), TRH(1), VIP(1) 15482614 45 34 45 2 6 11 9 9 10 0 0.00166 0.230 1.000 4 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(4), GNAQ(1), GNB1(2), HTR2C(6), PLCB1(13), TUB(4) 10147428 30 25 30 3 8 5 4 7 6 0 0.0399 0.293 1.000 5 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(3), GSTZ1(1), HGD(4) 3248696 8 8 8 1 1 1 2 3 1 0 0.395 0.304 1.000 6 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(4), GOT1(2), GOT2(1), TAT(3), TYR(5) 6774381 15 14 15 2 4 2 5 2 2 0 0.269 0.321 1.000 7 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(4), IL8(1), SLPI(1) 2293210 6 6 6 1 0 0 3 2 1 0 0.591 0.336 1.000 8 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 11 APAF1(11), BAD(1), BAK1(3), BAX(3), BCL10(3), BCL2L1(1), BCL2L11(5), BID(4), CASP9(3), CES1(4) 10857957 38 31 38 4 7 16 5 5 5 0 0.0362 0.398 1.000 9 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), CSF1(5), MST1(7), MST1R(8) 8247485 21 17 20 2 4 8 4 2 3 0 0.0603 0.415 1.000 10 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(3), CCNH(2), CDC25A(1), CDC25B(3), CDC25C(6), CDK7(3), MNAT1(2), SHH(1), XPO1(15) 12399459 36 30 35 3 8 17 4 2 5 0 0.0234 0.416 1.000 11 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(1) 738841 1 1 1 0 0 0 0 1 0 0 0.800 0.422 1.000 12 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(5), SUCLA2(1) 3040859 6 6 6 1 2 1 0 2 1 0 0.484 0.429 1.000 13 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(5), HLCS(3), SPCS3(1) 4475834 9 9 9 0 1 5 3 0 0 0 0.0651 0.496 1.000 14 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 5 NFYB(1), NFYC(4), SP1(6), SP3(7) 7095469 18 18 17 3 0 5 2 5 6 0 0.413 0.521 1.000 15 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(1), CD28(2), CD3E(3), CD3G(3), CD4(4) 4747896 13 12 13 3 1 3 2 3 4 0 0.519 0.532 1.000 16 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 9 B3GALT1(3), B3GALT2(2), B3GALT5(2), B3GNT5(4), FUT1(1), FUT3(3), ST3GAL3(5), ST3GAL4(2) 9401425 22 19 22 2 5 7 7 3 0 0 0.0385 0.557 1.000 17 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), DAG1(2), GNAQ(1), ITPKA(1), ITPKB(8) 7938257 13 13 13 1 2 4 1 4 2 0 0.138 0.571 1.000 18 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(6), CYP2C9(3) 2941407 9 9 9 2 1 4 2 2 0 0 0.487 0.572 1.000 19 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(4), GSS(3), IL8(1), NFKB1(5), NOX1(5), RELA(3), SOD1(1), XDH(9) 14003534 31 30 31 2 5 9 3 7 7 0 0.0155 0.588 1.000 20 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(11), BAK1(3), BAX(3), BCL2L1(1), BID(4), BIK(1), BIRC2(3), BIRC3(4), CASP3(1), CASP6(2), CASP7(2), CASP9(3), DFFA(4), DFFB(2), DIABLO(1) 17624863 45 33 44 2 4 20 7 3 11 0 0.00399 0.611 1.000 21 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 6 CCNE1(2), CDC34(1), CDK2(2), CUL1(2), E2F1(5), TFDP1(3) 7059391 15 15 14 3 4 3 2 1 5 0 0.516 0.634 1.000 22 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), IFNGR1(2), JAK1(11), JAK2(7), STAT1(4) 11988633 26 24 26 2 2 5 6 5 8 0 0.0771 0.642 1.000 23 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(1), EPHX2(4), HSD3B7(1), RDH11(4), RDH12(2), RDH13(2), RDH14(2) 6722905 16 16 16 3 2 3 4 4 3 0 0.274 0.648 1.000 24 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(12), CD44(4), CSF1(5), FCGR3A(4), IL6R(5), SELL(6), SPN(2), TGFB1(2), TGFB2(1), TNFRSF1A(4), TNFRSF1B(2), TNFRSF8(4), TNFSF8(1) 18683248 52 39 50 6 9 13 5 13 12 0 0.0139 0.650 1.000 25 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(1) 1046953 1 1 1 1 0 0 0 0 1 0 0.943 0.671 1.000 26 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(1), ADH1C(4), ADH4(1), ADH6(2), ADH7(3), ADHFE1(2) 8274194 13 13 13 2 3 2 7 0 1 0 0.327 0.681 1.000 27 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(3), F13B(5), HSD17B1(1), HSD17B2(4), HSD17B3(2), HSD17B4(8), HSD17B7(1), HSD3B1(3), HSD3B2(4) 11635128 31 31 30 6 3 8 10 6 4 0 0.272 0.701 1.000 28 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(4), CHRNA1(4), SNAP25(4), STX1A(3), VAMP2(1) 4601119 16 14 16 4 3 6 3 3 1 0 0.417 0.702 1.000 29 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(2), NDUFA10(1), NDUFA4(1), NDUFB5(4), NDUFB6(2), NDUFS1(1), NDUFS2(7), NDUFV1(5), NDUFV2(1) 10292419 24 22 24 3 5 4 4 7 4 0 0.195 0.706 1.000 30 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 3 CD28(2), CD4(4), HLA-DRB1(10) 2582311 16 15 16 8 1 2 5 4 4 0 0.911 0.706 1.000 31 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(2), GOT2(1), TAT(3) 3780433 6 5 6 1 1 1 1 1 2 0 0.642 0.711 1.000 32 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(1), DHRS2(4), DHRS3(1), DHRS7(4), DHRSX(1), HSD3B7(1), PON1(4), PON2(1), PON3(4), RDH11(4), RDH12(2), RDH13(2), RDH14(2) 12737805 31 25 31 4 1 9 5 12 4 0 0.0581 0.718 1.000 33 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 10 CCNE1(2), CDK2(2), CKS1B(1), CUL1(2), E2F1(5), SKP2(2), TFDP1(3) 9332326 17 17 16 3 4 5 2 2 4 0 0.415 0.727 1.000 34 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(6), GAD1(3), PNMT(1), TH(2), TPH1(3) 7961250 15 13 15 2 5 4 2 1 3 0 0.190 0.744 1.000 35 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 10 ATM(23), CDC25A(1), CDC25B(3), CDC25C(6), CDK2(2), CDK4(1), CHEK1(2), MYT1(10), WEE1(4) 21895875 52 47 51 6 5 18 5 10 14 0 0.0822 0.755 1.000 36 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(23), CDC25A(1), CDC25B(3), CDC25C(6), CHEK1(2), MYT1(10), WEE1(4) 20080255 49 44 48 6 5 18 5 9 12 0 0.105 0.761 1.000 37 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(1), CD3E(3), CD3G(3), CXCR3(6), ETV5(9), IFNG(2), IL12B(2), IL12RB1(7), IL12RB2(4), IL18(2), IL18R1(4), JAK2(7), JUN(3), MAP2K6(1), MAPK14(2), MAPK8(2), STAT4(8), TYK2(8) 27009540 74 61 72 10 12 18 11 17 16 0 0.0299 0.768 1.000 38 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(2), CDK5R1(1), DAB1(5), LRP8(6), RELN(26), VLDLR(9) 20116514 49 38 47 4 9 12 14 7 6 1 0.00616 0.769 1.000 39 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(1), NFKB1(5), NFKBIA(3), PLCB1(13), PRKCA(4), RELA(3) 11773653 29 24 29 4 6 4 5 5 9 0 0.154 0.788 1.000 40 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1), TPI1(2) 2285289 3 3 3 1 0 1 1 0 1 0 0.761 0.789 1.000 41 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 8 CCNE1(2), CDC34(1), CDK2(2), CUL1(2), E2F1(5), SKP2(2), TFDP1(3) 9880734 17 17 16 3 4 5 2 1 5 0 0.401 0.802 1.000 42 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 14 ATN1(10), BAIAP2(2), CASP1(3), CASP3(1), CASP7(2), GAPDH(1), INSR(11), ITCH(4), MAGI1(17), MAGI2(9), RERE(13), WWP1(6), WWP2(12) 31661231 91 60 88 9 12 34 13 23 8 1 0.000541 0.803 1.000 43 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(1), GALT(2), TGDS(3), UGDH(1), UGP2(4), UXS1(3) 7314842 14 13 14 2 2 7 3 1 1 0 0.287 0.817 1.000 44 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(2), PAPSS1(2), PAPSS2(2), SULT1A2(2), SULT1E1(4), SUOX(4) 8879120 16 14 16 2 3 3 4 4 2 0 0.278 0.832 1.000 45 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(3), PGLYRP2(1) 2463299 4 4 4 2 0 0 0 2 2 0 0.916 0.856 1.000 46 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(8), DNAJC3(4), EIF2S1(3), EIF2S2(3), NFKB1(5), NFKBIA(3), RELA(3) 13249927 29 25 29 3 10 9 4 1 5 0 0.0601 0.863 1.000 47 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP2(2), ACP5(3), ACPP(6), ACPT(1), ENPP1(7), ENPP3(6), FLAD1(8), RFK(1), TYR(5) 14072621 39 33 38 6 8 8 11 6 6 0 0.0839 0.864 1.000 48 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 7 CCL11(1), CCR3(2), HLA-DRB1(10), IL3(1) 3487909 14 13 14 6 1 2 4 4 3 0 0.863 0.868 1.000 49 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1), ALDOA(5), ALDOB(3), ALDOC(2), TPI1(2) 5543262 13 13 13 3 2 7 1 2 1 0 0.375 0.874 1.000 50 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GBA(2), GBA3(4), GGT1(4), SHMT1(1), SHMT2(4) 8041021 15 14 15 3 3 4 2 4 2 0 0.370 0.874 1.000 51 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(1), GALT(2), TGDS(3), UGDH(1), UXS1(3) 5788071 10 9 10 2 2 4 3 1 0 0 0.476 0.875 1.000 52 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(3), ARG1(3), GLS(5), GLUD1(2), OAT(2), PRODH(2) 7874276 17 13 17 2 2 5 2 3 5 0 0.276 0.879 1.000 53 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(5), ADRB2(2), CFTR(14), GNAS(11), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), SLC9A3R1(3) 17760037 50 38 50 8 13 9 8 8 12 0 0.0875 0.880 1.000 54 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(5), CREM(3), FHL5(3), FSHR(9), GNAS(11), XPO1(15) 12897294 46 37 45 9 11 10 9 10 6 0 0.314 0.882 1.000 55 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 16 CARS(5), CARS2(5), CDO1(3), CTH(3), GOT1(2), GOT2(1), LDHA(3), LDHC(4), SULT1B1(2), SULT1C2(2), SULT1C4(1), SULT4A1(2) 17542811 33 31 33 4 2 13 4 3 11 0 0.0970 0.884 1.000 56 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(2), COQ5(1), COQ6(4), NDUFA13(1) 6022984 8 8 8 0 1 3 2 2 0 0 0.132 0.887 1.000 57 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(11), JAK2(7), JAK3(8), MAPK1(1), MAPK3(1), STAT3(5), TYK2(8) 16414334 41 35 39 6 9 5 9 7 11 0 0.118 0.892 1.000 58 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(5), MAX(2), MYC(1), SP1(6), SP3(7), WT1(4) 8581979 25 23 24 5 5 6 2 6 6 0 0.382 0.903 1.000 59 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(3), LPL(1), NR3C1(3), PPARG(5), RXRA(2) 7579786 14 14 13 3 3 2 4 2 3 0 0.452 0.912 1.000 60 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL13RA2(5), IL4R(6), JAK1(11), JAK2(7), TYK2(8) 14824682 38 34 36 6 4 4 12 8 10 0 0.229 0.915 1.000 61 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL13RA2(5), IL4R(6), JAK1(11), JAK2(7), TYK2(8) 14824682 38 34 36 6 4 4 12 8 10 0 0.229 0.915 1.000 62 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(5), CDO1(3), CSAD(6), GAD1(3), GAD2(3), GGT1(4) 8090557 24 22 24 5 4 10 4 2 4 0 0.270 0.922 1.000 63 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(1), GBA3(4), GGT1(4), SHMT1(1), SHMT2(4) 5971765 14 13 14 4 4 3 2 3 2 0 0.545 0.924 1.000 64 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(2), ST3GAL1(2), ST3GAL2(2), ST3GAL4(2), ST3GAL5(2), ST6GALNAC2(2), ST6GALNAC4(1), ST8SIA1(1) 7663375 14 14 14 3 2 3 4 4 1 0 0.447 0.924 1.000 65 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 7 CARS(5), CTH(3), GOT1(2), GOT2(1), LDHA(3), LDHC(4) 9359890 18 16 18 3 1 6 3 2 6 0 0.324 0.924 1.000 66 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 7 CD28(2), CD4(4), HLA-DRB1(10), IL4(1) 4893098 17 16 17 9 1 2 5 4 5 0 0.958 0.928 1.000 67 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(23), ATR(13), CDC25C(6), CHEK1(2), CHEK2(6) 21964219 50 43 49 7 6 17 5 10 12 0 0.178 0.928 1.000 68 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(3), AKR1D1(1), CYP11A1(1), CYP11B1(5), CYP11B2(4), CYP17A1(3), CYP21A2(3), HSD11B1(3), HSD11B2(2), HSD3B1(3), HSD3B2(4) 12832568 32 30 31 6 4 12 8 5 3 0 0.116 0.929 1.000 69 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(3), AKR1D1(1), CYP11A1(1), CYP11B1(5), CYP11B2(4), CYP17A1(3), CYP21A2(3), HSD11B1(3), HSD11B2(2), HSD3B1(3), HSD3B2(4) 12832568 32 30 31 6 4 12 8 5 3 0 0.116 0.929 1.000 70 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 17 ATF2(4), CHUK(8), IFNG(2), IKBKB(6), IL4(1), JUN(3), MAP3K5(12), MAP4K5(1), MAPK14(2), MAPK8(2), NFKB1(5), NFKBIA(3), RELA(3), TNFRSF9(2), TNFSF9(1), TRAF2(1) 24396614 56 44 55 8 14 15 7 4 16 0 0.0727 0.930 1.000 71 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(3), OXCT1(5) 4916287 8 6 8 2 1 4 0 3 0 0 0.572 0.932 1.000 72 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS1(6), ALAS2(8), HMBS(3), PPOX(6), UROD(2), UROS(2) 11213226 27 23 26 5 4 6 6 7 4 0 0.298 0.934 1.000 73 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 18 B2M(3), HLA-A(3), IL18(2), ITGB1(5), KLRC1(5), KLRC3(1), KLRD1(1), LAT(1), MAP2K1(5), MAPK3(1), PAK1(4), PTK2B(7), PTPN6(2), SYK(4), VAV1(6) 21524409 50 45 49 7 6 14 10 14 6 0 0.0497 0.935 1.000 74 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1), BCKDK(5), CBS(1), CTH(3), MUT(3) 6896259 13 13 13 3 2 3 2 2 4 0 0.524 0.937 1.000 75 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 18 AKT1(2), CCND1(1), CCNE1(2), CDK2(2), CDK4(1), CDK6(2), CDKN1A(1), E2F1(5), HRAS(2), MAPK1(1), MAPK3(1), NFKB1(5), NFKBIA(3), PAK1(4), RAF1(4), RELA(3), TFDP1(3) 20136632 42 38 41 6 12 9 5 7 9 0 0.0651 0.942 1.000 76 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(3), ASL(4), CPS1(12), GLS(5), GLUD1(2), GOT1(2) 11110445 28 23 28 5 1 5 11 6 5 0 0.318 0.944 1.000 77 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 22 ATF1(3), CASP2(3), CHUK(8), IKBKB(6), JUN(3), LTA(2), MAP2K3(3), MAP2K6(1), MAP4K2(2), MAPK14(2), MAPK8(2), NFKB1(5), NFKBIA(3), RELA(3), RIPK1(5), TANK(3), TNFRSF1A(4), TRAF2(1) 28576328 59 48 58 6 12 18 9 7 13 0 0.00492 0.950 1.000 78 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS1(6), ALAS2(8), GATA1(2), HBA2(2), HBB(1), HMBS(3), UROD(2), UROS(2) 11907873 26 22 25 5 5 6 5 6 4 0 0.308 0.951 1.000 79 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 6 FUT1(1), FUT3(3), FUT5(2), FUT6(3), ST3GAL3(5) 6000163 14 14 14 4 4 3 4 2 1 0 0.472 0.952 1.000 80 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(3), HK1(3), HK2(5), HK3(5), IMPA1(3), PGM1(5), PGM3(2), TGDS(3) 14547260 29 25 29 4 4 4 6 11 4 0 0.0883 0.957 1.000 81 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(3), HK1(3), HK2(5), HK3(5), IMPA1(3), IMPA2(4), ISYNA1(1), PGM1(5), PGM3(2), TGDS(3) 16286781 34 29 34 5 6 4 7 12 5 0 0.0722 0.957 1.000 82 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 FOS(1), HRAS(2), JUN(3), MAP2K1(5), MAPK1(1), MAPK3(1), MYC(1), NFKB1(5), NFKBIA(3), PLCB1(13), PRKCA(4), RAF1(4), RELA(3) 21335411 46 38 46 6 10 10 5 10 11 0 0.0439 0.959 1.000 83 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(4), GBA3(4), LPO(4), MPO(5), PRDX1(3), PRDX2(1), PRDX5(4), TPO(8), TYR(5) 13818300 38 35 38 8 8 8 7 8 7 0 0.244 0.960 1.000 84 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 14 APAF1(11), ATM(23), BAX(3), CCND1(1), CCNE1(2), CDK2(2), CDK4(1), CDKN1A(1), E2F1(5), MDM2(3), TIMP3(3) 22211464 55 46 54 9 9 15 5 9 17 0 0.242 0.963 1.000 85 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), UGDH(1) 11889086 18 18 17 2 4 3 4 2 5 0 0.144 0.969 1.000 86 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(4), FARSA(3), FARSB(5), GOT1(2), GOT2(1), PAH(3), TAT(3), YARS(4), YARS2(1) 12532648 26 20 26 4 3 11 3 5 4 0 0.211 0.970 1.000 87 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(3), KHK(4), LCT(17), MPI(2), PGM1(5), PYGL(3), PYGM(5), TPI1(2), TREH(2) 19328590 43 39 43 8 8 7 8 11 9 0 0.137 0.972 1.000 88 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(1), CDC25B(3), CDK7(3), CDKN1A(1), CHEK1(2), NEK1(6), WEE1(4) 11028581 20 18 20 3 3 10 0 1 6 0 0.515 0.977 1.000 89 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 19 CCNB1(3), CCND1(1), CCND2(3), CCND3(5), CCNE1(2), CCNH(2), CDC25A(1), CDK2(2), CDK4(1), CDK6(2), CDK7(3), CDKN1A(1), CDKN2A(1), E2F1(5), RBL1(6), TFDP1(3) 19043618 41 38 40 7 6 8 9 5 12 1 0.253 0.978 1.000 90 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 8 BAG4(1), BIRC3(4), RIPK1(5), TNFRSF1A(4), TNFRSF1B(2), TRAF2(1) 8859192 17 15 16 4 4 7 3 0 3 0 0.465 0.981 1.000 91 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(1), GNAS(11), GNB1(2), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKCA(4) 13298783 33 29 33 6 6 8 6 4 9 0 0.317 0.982 1.000 92 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 15 DNAJA3(2), IFNG(2), IFNGR1(2), IKBKB(6), JAK2(7), LIN7A(1), NFKB1(5), NFKBIA(3), RELA(3), TNFRSF1A(4), TNFRSF1B(2), USH1C(8), WT1(4) 21245296 49 37 48 7 11 15 6 4 13 0 0.0413 0.982 1.000 93 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 5 CASP3(1), CFL1(1), CFLAR(1) 3763315 3 3 3 1 0 0 1 1 1 0 0.772 0.983 1.000 94 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(4), CDKN1A(1), EPO(1), EPOR(4), GRIN1(3), HIF1A(4), JAK2(7), NFKB1(5), NFKBIA(3), RELA(3) 17959980 35 31 35 5 6 13 3 4 9 0 0.118 0.983 1.000 95 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), ALG5(5), B4GALT1(3), B4GALT3(2), B4GALT5(4), DDOST(2), DPAGT1(4), DPM1(4), FUT8(2), MAN1A1(6), MAN1B1(3), MGAT3(4), MGAT4A(4), MGAT4B(5), MGAT5(3), RPN1(4), RPN2(2), ST6GAL1(3) 26640907 61 44 61 9 8 19 14 10 9 1 0.0346 0.986 1.000 96 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(2), CDK5R1(1), DPM2(1), EGR1(3), HRAS(2), KLK2(3), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), NGFR(1), RAF1(4) 11221001 26 24 25 5 4 7 3 7 5 0 0.241 0.986 1.000 97 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 16 ALOX12(7), ALOX15(4), ALOX15B(5), ALOX5(3), ALOX5AP(1), DPEP1(2), GGT1(4), LTA4H(2), PLA2G2A(1), PLA2G6(2), PTGDS(4), PTGIS(4), PTGS1(5), PTGS2(5), TBXAS1(3) 21297488 52 41 52 8 10 11 13 9 9 0 0.0340 0.987 1.000 98 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(8), CKM(1), FBL(4), GPT(2), LDHA(3), LDHC(4), MAPK14(2), NCL(7) 13000130 31 27 31 6 5 10 8 4 4 0 0.283 0.988 1.000 99 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(1), CCR3(2), CFL1(1), GNAQ(1), GNAS(11), GNB1(2), HRAS(2), LIMK1(8), MAP2K1(5), MAPK1(1), MAPK3(1), NOX1(5), PIK3C2G(8), PLCB1(13), PPP1R12B(4), PRKCA(4), PTK2(7), RAF1(4), ROCK2(9) 36460410 89 68 87 10 14 21 14 18 22 0 0.0124 0.989 1.000 100 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(3), BMPR1A(1), BMPR1B(6), BMPR2(8) 8792759 18 16 17 7 1 2 4 5 6 0 0.893 0.990 1.000 101 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(3), CYP11A1(1), CYP11B2(4), CYP17A1(3), HSD11B1(3), HSD11B2(2), HSD3B1(3), HSD3B2(4) 9789566 23 22 22 6 2 7 6 6 2 0 0.322 0.991 1.000 102 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(2), IFNG(2), IFNGR1(2), JAK1(11), JAK2(7), PLA2G2A(1), PTPRU(10), REG1A(1), STAT1(4) 16457271 40 35 40 8 5 7 9 8 10 1 0.352 0.991 1.000 103 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO2(1), ENO3(2), FARS2(4), GOT1(2), GOT2(1), PAH(3), TAT(3), YARS(4) 11950977 20 15 20 3 3 5 5 5 2 0 0.216 0.992 1.000 104 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 11 APAF1(11), ARHGAP5(12), ARHGDIB(1), CASP1(3), CASP10(2), CASP3(1), CASP9(3), JUN(3), PRF1(2) 16739655 38 30 38 6 5 9 6 4 14 0 0.271 0.992 1.000 105 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(2), PSMA2(1), PSMA3(4), PSMA5(2), PSMA6(2), PSMA7(3), PSMB10(1), PSMB4(1), PSMB5(2), PSMB6(2) 11740592 20 20 19 4 2 9 3 5 1 0 0.322 0.993 1.000 106 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(4), IARS(8), LARS(5), LARS2(3), PDHA1(2), PDHA2(4), PDHB(1) 14612241 27 24 27 5 3 10 6 6 2 0 0.258 0.993 1.000 107 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 13 ARF1(2), CCND1(1), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(1), CFL1(1), E2F1(5), MDM2(3), PRB1(3) 9422780 20 20 19 5 5 1 2 3 9 0 0.671 0.994 1.000 108 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 14 APAF1(11), BIRC2(3), BIRC3(4), CASP10(2), CASP3(1), CASP7(2), CASP9(3), DFFA(4), DFFB(2), PRF1(2), SCAP(2), SREBF1(4), SREBF2(6) 23236410 46 35 45 7 5 19 10 2 10 0 0.0863 0.994 1.000 109 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 4 CDK5(2), FOSB(2), GRIA2(4) 5072210 8 8 8 3 3 3 2 0 0 0 0.695 0.994 1.000 110 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(4), ALDH1A2(1), BCMO1(5), RDH5(1) 5555924 11 10 11 9 2 1 3 1 4 0 0.995 0.995 1.000 111 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(1), NRF1(3), UBE2A(2), UBE2C(1), UBE2D1(1), UBE2D2(3), UBE2D3(2), UBE2E1(1), UBE2E3(1), UBE2I(1), UBE2J1(3), UBE2J2(2), UBE2L3(1), UBE2L6(2), UBE3A(3) 14852819 27 25 27 5 3 7 7 4 6 0 0.352 0.995 1.000 112 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(5), GLUD1(2), GLUD2(3) 6372372 10 9 10 3 3 1 1 2 3 0 0.776 0.995 1.000 113 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(7), PNPO(2), PSAT1(1) 6829010 10 9 10 3 2 2 2 1 3 0 0.660 0.996 1.000 114 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(1), PLCD1(3), PRKCA(4), TGM2(7) 6992505 15 13 15 7 3 4 1 1 6 0 0.857 0.996 1.000 115 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(3), CBS(1), CTH(3), GGT1(4), MARS(11), MARS2(1), MAT1A(2), MAT2B(2), PAPSS1(2), PAPSS2(2), SCLY(4), SEPHS1(2) 17363140 37 29 36 7 9 8 9 5 6 0 0.109 0.996 1.000 116 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(4), CD8A(3), CSF1(5), CSF3(2), EPO(1), IL11(1), IL3(1), IL4(1), IL6(2), IL7(1), IL8(1) 8721905 22 20 22 6 3 7 4 1 7 0 0.513 0.996 1.000 117 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(3), CHAT(2), COMT(1), DBH(6), DDC(4), GAD1(3), GAD2(3), MAOA(2), PAH(3), PNMT(1), SLC18A3(3), TH(2), TPH1(3) 19286564 37 34 37 6 11 7 7 5 7 0 0.0923 0.996 1.000 118 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP3(1), CASP7(2), DFFA(4), DFFB(2), HMGB1(2), HMGB2(3), TOP2A(3), TOP2B(6) 15293450 23 17 22 2 0 10 3 5 5 0 0.162 0.996 1.000 119 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(3), ADCY1(5), CAP1(3), CCNB1(3), CDC25C(6), GNAI1(2), GNAS(11), GNB1(2), HRAS(2), MAPK1(1), MAPK3(1), MYT1(10), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), RPS6KA1(7), SRC(1) 28232840 72 59 71 12 17 17 12 9 16 1 0.0586 0.996 1.000 120 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(3), RAB11A(3), RAB1A(2), RAB27A(1), RAB3A(2), RAB6A(6), RAB9A(1) 6236461 18 15 18 5 1 6 5 2 3 1 0.635 0.996 1.000 121 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 12 AKT1(2), CREB1(2), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K6(1), MAPK1(1), MAPK14(2), MAPK3(1), NFKB1(5), RELA(3), SP1(6) 16144074 33 32 33 6 6 12 6 7 2 0 0.159 0.996 1.000 122 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(7), ALDH4A1(3), ALDH5A1(2), CAD(17), CPS1(12), EPRS(11), GAD1(3), GAD2(3), GCLC(2), GCLM(2), GFPT1(3), GLS(5), GLUD1(2), GLUL(3), GMPS(5), GOT1(2), GOT2(1), GPT(2), GPT2(3), GSS(3), NADSYN1(6), PPAT(5), QARS(10) 47656764 112 79 112 16 10 39 23 21 19 0 0.00417 0.996 1.000 123 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(12), AGT(3), AGTR1(4), AGTR2(2), BDKRB2(4), KNG1(4), NOS3(3), REN(1) 13588029 33 29 33 8 7 10 5 7 4 0 0.273 0.997 1.000 124 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(1), ADH1C(4), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1) 19212154 35 31 34 6 7 6 13 3 6 0 0.151 0.997 1.000 125 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP2(2), ACP5(3), ACP6(2), ACPP(6), ACPT(1), ENPP1(7), ENPP3(6), FLAD1(8), MTMR1(1), MTMR2(2), MTMR6(3), RFK(1), TYR(5) 21704622 47 38 46 8 9 12 12 7 7 0 0.115 0.997 1.000 126 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 20 APAF1(11), ARHGDIB(1), BIRC2(3), BIRC3(4), CASP1(3), CASP10(2), CASP2(3), CASP3(1), CASP4(1), CASP6(2), CASP7(2), CASP9(3), DFFA(4), DFFB(2), LMNA(4), LMNB1(2), LMNB2(3), PRF1(2) 25575901 53 40 52 8 5 18 11 6 13 0 0.156 0.997 1.000 127 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(4), CD34(3), CD3E(3), CD3G(3), CD4(4), CD58(2), CD8A(3), CSF3(2), IL3(1), IL6(2), IL8(1), KITLG(3) 9035804 31 27 31 9 2 10 6 4 9 0 0.588 0.998 1.000 128 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(1), B4GALT1(3), B4GALT3(2), B4GALT5(4), FUT8(2), ST3GAL1(2), ST3GAL2(2), ST3GAL3(5), ST3GAL4(2) 10964043 23 21 23 5 3 10 5 3 2 0 0.341 0.998 1.000 129 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(1), CD36(5), FOS(1), JUN(3), MAPK14(2), THBS1(8) 10269807 20 16 19 8 3 1 2 6 8 0 0.954 0.998 1.000 130 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 12 CCNA2(4), CCND1(1), CCNE1(2), CCNE2(4), CDK2(2), CDK4(1), CDKN2A(1), E2F1(5), E2F4(2), PRB1(3) 11609259 25 22 24 6 5 6 3 3 8 0 0.513 0.998 1.000 131 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(4), FDPS(5), IDI1(7), SQLE(2) 4783862 18 17 17 5 4 7 3 1 3 0 0.673 0.998 1.000 132 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(8), DUSP1(1), IKBKAP(12), IKBKB(6), NFKB1(5), NFKBIA(3), RELA(3), TNFAIP3(3), TRAF3(3), TRAF6(4) 22633155 48 37 48 9 8 14 7 6 12 1 0.174 0.998 1.000 133 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 16 CD28(2), CD86(6), HLA-DRB1(10), IFNG(2), IFNGR1(2), IL12B(2), IL12RB1(7), IL12RB2(4), IL18(2), IL18R1(4), IL2RA(2), IL4(1), IL4R(6) 17605712 50 42 50 11 4 11 13 16 6 0 0.300 0.998 1.000 134 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(1), B3GNT2(2), B3GNT7(2), B4GALT1(3), B4GALT3(2), B4GALT4(2), CHST1(4), CHST2(5), CHST4(1), FUT8(2), ST3GAL1(2), ST3GAL2(2), ST3GAL3(5), ST3GAL4(2) 15861121 35 31 35 7 9 9 8 5 4 0 0.174 0.998 1.000 135 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG3(2), ATG5(4), ATG7(5), GABARAP(2), IFNA1(1), IFNA10(3), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(3), IFNA2(3), IFNA21(4), IFNA4(2), IFNA6(1), IFNA7(2), IFNA8(2), IFNG(2), PIK3C3(6), PIK3R4(10), PRKAA1(3), PRKAA2(2), ULK1(5), ULK2(6), ULK3(5) 30206756 82 62 82 13 6 35 17 18 6 0 0.0385 0.998 1.000 136 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), EHHADH(4), HADHA(3) 7027296 8 8 8 3 0 2 3 2 1 0 0.798 0.998 1.000 137 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 17 BAD(1), BAX(3), MAP2K1(5), MAPK1(1), MAPK3(1), MAPK8(2), NFKB1(5), NSMAF(3), RAF1(4), RELA(3), RIPK1(5), SMPD1(2), TNFRSF1A(4), TRAF2(1) 21713310 40 31 39 5 9 15 3 4 9 0 0.0316 0.998 1.000 138 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(8), MAPK14(2), MAPK8(2), NFKB1(5), RELA(3), TNFRSF13B(2), TNFSF13(1), TNFSF13B(1), TRAF2(1), TRAF3(3), TRAF5(3), TRAF6(4) 20720942 35 32 35 5 7 9 5 4 9 1 0.132 0.999 1.000 139 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(2), APEX1(4), CREBBP(15), DFFA(4), DFFB(2), GZMA(2), HMGB2(3), PRF1(2) 15283074 34 29 33 7 6 8 5 7 8 0 0.355 0.999 1.000 140 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(2), HRAS(2), PTK2B(7), SHC1(2), SOS1(5), SRC(1) 12346233 19 19 19 4 5 4 4 3 3 0 0.391 0.999 1.000 141 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 12 AKT1(2), BAD(1), CASP9(3), CHUK(8), GHR(5), NFKB1(5), NFKBIA(3), PDPK1(2), PPP2CA(3), RELA(3) 14675502 35 27 35 7 9 12 5 2 7 0 0.290 0.999 1.000 142 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 30 APAF1(11), BID(4), BIRC2(3), BIRC3(4), CASP10(2), CASP3(1), CASP6(2), CASP7(2), CASP9(3), CFLAR(1), CHUK(8), DFFA(4), DFFB(2), GAS2(3), LMNA(4), NFKB1(5), NFKBIA(3), RELA(3), RIPK1(5), SPTAN1(13), TNFRSF10A(1), TNFRSF10B(1), TNFRSF25(2), TRAF2(1) 45481112 88 61 87 8 18 30 16 7 17 0 0.000804 0.999 1.000 143 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(2), CD3E(3), CD3G(3), IFNG(2), IL2RA(2), IL4(1), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TGFBR2(4), TGFBR3(4), TOB1(2) 15467259 31 28 31 7 6 8 4 9 4 0 0.380 0.999 1.000 144 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(4), BLVRB(1), IL10RA(1), IL10RB(3), IL1A(1), IL6(2), JAK1(11), STAT1(4), STAT3(5), STAT5A(6) 17086057 38 33 38 8 5 8 9 9 7 0 0.228 0.999 1.000 145 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(1), CD2(4), CD3E(3), CD3G(3), CD4(4), CXCR3(6), IFNG(2), IL12B(2), IL12RB1(7), IL12RB2(4), JAK2(7), STAT4(8), TYK2(8) 21397280 59 48 57 12 8 12 11 14 14 0 0.256 0.999 1.000 146 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 5 AKT1(2), PLCB1(13), PLCG1(8), PRKCA(4), VAV1(6) 13131429 33 29 33 7 8 4 5 7 9 0 0.360 0.999 1.000 147 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 15 ADRB2(2), AKT1(2), ANXA1(5), CALM2(2), GNAS(11), GNB1(2), NFKB1(5), NOS3(3), NPPA(1), NR3C1(3), RELA(3), SYT1(2) 19334392 41 36 41 7 11 10 5 7 8 0 0.202 0.999 1.000 148 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(2), PSMA2(1), PSMA3(4), PSMA5(2), PSMA6(2), PSMA7(3), PSMB4(1), PSMB5(2), PSMB6(2), PSMC3(3), PSMD14(1), RPN1(4), RPN2(2), UBE2A(2), UBE3A(3) 19214893 34 31 33 6 4 12 5 8 4 1 0.230 0.999 1.000 149 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(1), IL22(2), IL22RA1(4), IL22RA2(3), JAK1(11), JAK2(7), JAK3(8), STAT1(4), STAT3(5), STAT5A(6), STAT5B(5), TYK2(8) 26016034 64 55 62 11 14 11 13 10 16 0 0.0683 1.000 1.000 150 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP2(2), ACP5(3), ACP6(2), ACPP(6), ACPT(1), ALPL(1), ALPP(3), ALPPL2(2), CMBL(1), CYP3A4(4), CYP3A43(3), CYP3A5(2), CYP3A7(5), DHRS2(4), DHRS3(1), DHRS7(4), DHRSX(1), PON1(4), PON2(1), PON3(4) 25301573 54 39 53 9 7 16 9 18 4 0 0.0450 1.000 1.000 151 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(2), PSMA2(1), PSMA3(4), PSMA5(2), PSMA6(2), PSMA7(3), PSMB4(1), PSMB5(2), PSMB6(2), PSMC3(3), PSMD1(9), PSMD11(3), PSMD12(3), PSMD13(2), PSMD2(2), PSMD6(3) 23377388 44 38 43 6 6 22 5 6 5 0 0.0647 1.000 1.000 152 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(1), ACADS(2), ACAT1(3), HADHA(3) 7607691 9 9 9 3 1 3 2 3 0 0 0.702 1.000 1.000 153 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(1), ACADS(2), ACADVL(5), ACSL1(3), ACSL3(3), ACSL4(5), CPT1A(6), CPT2(5), EHHADH(4), HADHA(3), SCP2(1), SLC25A20(4) 24001555 42 31 42 7 8 9 10 9 6 0 0.0947 1.000 1.000 154 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 12 CREB1(2), FOS(1), JUN(3), KEAP1(3), MAPK1(1), MAPK14(2), MAPK8(2), NFE2L2(3), PRKCA(4) 12277885 21 20 21 7 5 4 2 2 7 1 0.825 1.000 1.000 155 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(7), ATM(23), BRCA1(14), CDKN1A(1), CHEK1(2), CHEK2(6), JUN(3), MAPK8(2), MDM2(3), MRE11A(8), NFKB1(5), NFKBIA(3), RAD50(6), RAD51(2), RBBP8(5), RELA(3), TP73(2) 40544887 95 82 94 13 13 34 8 15 25 0 0.0610 1.000 1.000 156 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNG(2), IL12B(2), IL15(3), IL16(7), IL18(2), IL1A(1), IL3(1), IL4(1), IL6(2), IL8(1), LTA(2) 13775870 25 21 25 6 3 7 5 7 3 0 0.424 1.000 1.000 157 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 12 ABL1(7), CDKN2A(1), E2F1(5), MDM2(3), MYC(1), POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(4), TBX2(1), TWIST1(2) 18342307 40 38 40 9 7 9 4 9 11 0 0.407 1.000 1.000 158 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(2), CYP2E1(2), NR1I3(2), PTGS1(5), PTGS2(5) 7597151 16 14 16 6 3 3 3 3 4 0 0.765 1.000 1.000 159 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(4), FOS(1), HRAS(2), IL3(1), IL3RA(3), JAK2(7), MAP2K1(5), MAPK3(1), PTPN6(2), RAF1(4), SHC1(2), SOS1(5), STAT5A(6), STAT5B(5) 25078782 48 45 48 8 10 13 6 9 10 0 0.0602 1.000 1.000 160 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(3), IFNG(2), IL12B(2), IL18(2) 4479603 9 9 9 4 1 1 1 5 1 0 0.878 1.000 1.000 161 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(9), CAPN1(8), CDK5(2), CDK5R1(1), CSNK1A1(4), GSK3B(2), MAPT(4), PPP2CA(3) 13265528 33 27 33 7 5 11 5 6 6 0 0.330 1.000 1.000 162 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(15), EP300(13), ESR1(7), MAPK1(1), MAPK3(1), PELP1(7), SRC(1) 21312407 45 38 45 8 8 9 8 11 9 0 0.171 1.000 1.000 163 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(1), BFAR(3), BRAF(5), CREB1(2), CREB3(1), CREB5(4), MAPK1(1), RAF1(4), SNX13(5), SRC(1), TERF2IP(3) 16710165 30 29 30 6 6 8 5 8 3 0 0.309 1.000 1.000 164 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(4), FDPS(5), GGPS1(2), IDI1(7), IDI2(1), SQLE(2) 6354231 21 17 20 6 4 10 3 1 3 0 0.689 1.000 1.000 165 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(8), PRKCA(4), PTK2B(7) 9584224 20 19 20 7 5 5 3 2 5 0 0.733 1.000 1.000 166 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(7), ADC(2), ALDH4A1(3), ALDH5A1(2), CAD(17), CPS1(12), EARS2(3), EPRS(11), GAD1(3), GAD2(3), GCLC(2), GCLM(2), GFPT1(3), GFPT2(9), GLS(5), GLUD1(2), GLUD2(3), GLUL(3), GMPS(5), GNPNAT1(2), GOT1(2), GOT2(1), GPT(2), GPT2(3), GSR(4), GSS(3), NADSYN1(6), NAGK(2), PPAT(5), QARS(10) 56813849 137 93 136 21 14 44 27 27 25 0 0.00336 1.000 1.000 167 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(2), B4GALNT1(1), GLB1(4), HEXA(3), HEXB(3), LCT(17), ST3GAL1(2), ST3GAL2(2), ST3GAL5(2), ST6GALNAC3(4), ST6GALNAC4(1), ST6GALNAC5(2), ST6GALNAC6(4), ST8SIA1(1) 22850437 48 43 48 10 7 13 10 11 7 0 0.196 1.000 1.000 168 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(4), ACO2(5), FH(3), IDH1(5), MDH1(1), SDHB(2), SUCLA2(1) 12982631 21 19 21 5 4 5 3 6 3 0 0.375 1.000 1.000 169 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(9), ABAT(7), ADSL(3), ADSS(3), AGXT(1), AGXT2(2), ASL(4), ASNS(3), ASPA(4), CAD(17), CRAT(8), DARS(4), DDO(1), GAD1(3), GAD2(3), GOT1(2), GOT2(1), GPT(2), GPT2(3), NARS(1), PC(10) 36910335 91 69 91 15 13 25 26 12 15 0 0.00897 1.000 1.000 170 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(5), ADRB2(2), GNAS(11), PLCE1(15), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), RAP2B(2) 20191676 50 44 50 10 12 8 11 7 12 0 0.247 1.000 1.000 171 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(2), IFNAR2(1), JAK1(11), STAT1(4), STAT2(5), TYK2(8) 15405586 32 29 30 8 4 4 8 7 9 0 0.587 1.000 1.000 172 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(5), CHPT1(4), HEMK1(2), LCMT1(1), LCMT2(10), METTL2B(4), METTL6(1), PCYT1A(2), PCYT1B(6), PRMT2(5), PRMT3(3), PRMT5(6), PRMT6(2), PRMT7(3), PRMT8(4), WBSCR22(2) 19599052 60 48 60 12 6 21 14 9 9 1 0.169 1.000 1.000 173 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 22 ATM(23), BMPR1B(6), CCND2(3), CDK4(1), DAZL(1), DMC1(2), EGR1(3), ESR2(5), FSHR(9), GJA4(1), INHA(5), LHCGR(10), MLH1(7), MSH5(7), NR5A1(1), NRIP1(10), PGR(6), PRLR(4), PTGER2(2), SMPD1(2), ZP2(4) 40487914 112 81 110 20 17 26 19 22 28 0 0.0774 1.000 1.000 174 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(4), GBA(2), GBA3(4), LPO(4), MPO(5), TPO(8) 11984083 27 25 27 7 7 7 2 6 5 0 0.415 1.000 1.000 175 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(5), DHRS2(4), DHRS3(1), DHRS7(4), DHRSX(1), HEMK1(2), LCMT1(1), LCMT2(10), METTL2B(4), METTL6(1), PRMT2(5), PRMT3(3), PRMT5(6), PRMT6(2), PRMT7(3), PRMT8(4), WBSCR22(2) 20773267 58 45 58 12 6 22 12 8 9 1 0.147 1.000 1.000 176 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(5), EGFR(5), ERBB3(19), NRG1(4), UBE2D1(1) 14745332 34 30 32 8 4 7 12 7 4 0 0.415 1.000 1.000 177 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(9), CS(2), MDH1(1), PC(10), PDHA1(2), SLC25A1(2), SLC25A11(2) 13008135 28 25 28 8 4 3 10 5 6 0 0.508 1.000 1.000 178 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 ANPEP(8), G6PD(4), GCLC(2), GCLM(2), GGT1(4), GPX2(1), GPX3(1), GPX4(1), GPX5(1), GSS(3), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTM4(2), GSTM5(1), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(5), MGST3(2), PGD(4) 25942568 51 39 50 9 6 12 11 15 7 0 0.0891 1.000 1.000 179 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(2), CDK5R1(1), DRD1(1), DRD2(3), GRM1(9), PLCB1(13), PPP2CA(3), PPP3CA(5), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2) 22591539 52 38 52 10 8 16 10 8 10 0 0.0897 1.000 1.000 180 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 10 AKT1(2), CAT(2), GHR(5), HRAS(2), IGF1R(7), SHC1(2), SOD1(1) 13109118 21 17 21 5 4 8 3 3 3 0 0.372 1.000 1.000 181 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SEC61A2(4), SRP19(1), SRP54(1), SRP68(3), SRP72(2), SRPR(8) 10924324 20 18 19 5 1 6 1 8 4 0 0.547 1.000 1.000 182 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(1), ACOX1(4), ACOX3(5), ELOVL5(5), ELOVL6(4), FADS1(4), FADS2(7), FASN(14), HADHA(3), SCD(1) 19479458 48 41 48 11 4 18 11 7 8 0 0.147 1.000 1.000 183 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP2(14), RANGAP1(3) 12199976 18 16 18 4 1 7 2 3 5 0 0.766 1.000 1.000 184 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 8 CAMK1(1), CAMK1G(5), HDAC9(5), MEF2A(6), MEF2C(4), MEF2D(3) 11826597 24 21 24 7 1 5 4 9 5 0 0.613 1.000 1.000 185 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(3), CDC25A(1), CDC25B(3), CDC25C(6), PRKCA(4), PTPRA(6), SRC(1) 13161000 24 23 24 6 4 9 2 4 5 0 0.493 1.000 1.000 186 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(4), ACO2(5), CS(2), DLD(1), DLST(3), FH(3), IDH1(5), IDH3A(2), IDH3B(2), IDH3G(1), MDH1(1), PC(10), PCK1(5), SDHB(2), SUCLA2(1), SUCLG2(1) 29730045 48 38 48 9 9 14 10 11 4 0 0.0705 1.000 1.000 187 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 11 AKT1(2), BAD(1), CHRNB1(2), CHRNG(2), MUSK(10), PTK2(7), PTK2B(7), SRC(1), TERT(2) 17858218 34 27 34 8 8 9 5 7 5 0 0.270 1.000 1.000 188 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 14 IL4(1), MAF(1), MAP2K3(3), MAPK14(2), NFATC1(5), NFATC2(4), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2) 13972134 31 29 31 9 4 10 8 3 6 0 0.420 1.000 1.000 189 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 15 AKT1(2), CREB1(2), HRAS(2), MAPK1(1), MAPK3(1), MAPK7(4), MEF2A(6), MEF2C(4), MEF2D(3), NTRK1(8), PLCG1(8), RPS6KA1(7), SHC1(2) 22226215 50 41 49 10 12 10 5 14 9 0 0.149 1.000 1.000 190 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(3), CCL2(1), CSF1(5), IL6(2), LDLR(6), LPL(1) 7488100 18 18 18 6 4 6 4 2 2 0 0.644 1.000 1.000 191 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(1), FUT1(1), GBGT1(2), GLA(5), HEXA(3), HEXB(3), NAGA(1), ST3GAL1(2), ST3GAL2(2), ST3GAL4(2), ST8SIA1(1) 13856861 23 21 23 6 3 9 3 5 3 0 0.498 1.000 1.000 192 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(6), AASDHPPT(4), AASS(5) 10159845 15 13 15 5 2 5 3 2 3 0 0.827 1.000 1.000 193 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), EHHADH(4), HADH(2), HADHA(3), HSD17B10(1), HSD17B4(8), NTAN1(1), SIRT1(2), SIRT2(1), SIRT5(1), SIRT7(4), VNN2(7) 17016995 35 33 35 9 6 13 9 5 2 0 0.487 1.000 1.000 194 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(14), NRG2(4), NRG3(7), PRKCA(4), PSEN1(2) 13134990 31 28 31 8 1 11 6 8 5 0 0.596 1.000 1.000 195 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), B4GALT7(1), HS3ST1(2), HS3ST2(4), HS3ST3A1(1), HS3ST3B1(1), XYLT1(4), XYLT2(5) 8222642 20 19 20 8 7 3 0 6 4 0 0.862 1.000 1.000 196 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), B4GALT7(1), HS3ST1(2), HS3ST2(4), HS3ST3A1(1), HS3ST3B1(1), XYLT1(4), XYLT2(5) 8222642 20 19 20 8 7 3 0 6 4 0 0.862 1.000 1.000 197 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(8), CREBBP(15), EP300(13), HDAC3(1), IKBKB(6), NFKB1(5), NFKBIA(3), RELA(3), RIPK1(5), TNFRSF1A(4), TNFRSF1B(2), TRAF6(4) 31273743 69 53 68 11 16 16 10 10 17 0 0.0598 1.000 1.000 198 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(4), CALCR(2), CALCRL(3), CD97(9), CRHR1(3), CRHR2(1), ELTD1(10), EMR1(5), EMR2(9), GHRHR(5), GIPR(1), GLP1R(2), GLP2R(4), GPR64(9), LPHN1(4), LPHN2(11), LPHN3(8), VIPR1(2), VIPR2(4) 39701150 96 76 96 21 12 27 19 17 20 1 0.0804 1.000 1.000 199 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(8), DUSP1(1), IKBKAP(12), IKBKB(6), LTA(2), NFKB1(5), NFKBIA(3), RELA(3), RIPK1(5), TANK(3), TNFAIP3(3), TNFRSF1B(2), TRAF1(2), TRAF2(1), TRAF3(3) 28232837 59 43 59 11 11 17 12 5 13 1 0.0969 1.000 1.000 200 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(4), APOBEC1(2), APOBEC2(2), APOBEC3A(2), APOBEC3B(2), APOBEC3C(2), APOBEC3G(3) 10659633 17 14 17 5 4 4 4 2 3 0 0.639 1.000 1.000 201 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASDHPPT(4), AASS(5) 6933326 9 8 9 5 2 3 2 1 1 0 0.938 1.000 1.000 202 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 14 AKT1(2), AKT2(5), AKT3(4), BPNT1(2), ILK(3), MAPK1(1), MAPK3(1), PDK1(2), PIK3CD(6), PTK2B(7), SHC1(2), SOS1(5) 24082803 40 37 40 8 8 10 6 7 9 0 0.236 1.000 1.000 203 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1) 11262296 22 20 21 8 5 3 6 2 6 0 0.779 1.000 1.000 204 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1) 11262296 22 20 21 8 5 3 6 2 6 0 0.779 1.000 1.000 205 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(3), BDH1(1), HMGCS1(6), HMGCS2(3), OXCT1(5), OXCT2(5) 10438872 23 17 21 7 5 8 1 7 2 0 0.639 1.000 1.000 206 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 62 APAF1(11), BAD(1), BAK1(3), BAX(3), BCL2L1(1), BCL2L11(5), BID(4), BIRC2(3), BIRC3(4), CASP1(3), CASP10(2), CASP2(3), CASP3(1), CASP4(1), CASP6(2), CASP7(2), CASP9(3), CHUK(8), DFFA(4), DFFB(2), FAS(1), FASLG(2), HELLS(3), IKBKB(6), IRF1(2), IRF2(1), IRF3(6), IRF4(2), IRF5(2), IRF6(3), IRF7(1), JUN(3), LTA(2), MAPK10(4), MDM2(3), MYC(1), NFKB1(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), PLEKHG5(2), PRF1(2), RELA(3), RIPK1(5), TNFRSF10B(1), TNFRSF1A(4), TNFRSF1B(2), TNFRSF21(2), TNFRSF25(2), TP73(2), TRAF1(2), TRAF2(1), TRAF3(3) 71154305 151 99 150 19 26 50 24 17 32 2 0.000426 1.000 1.000 207 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(3), CARM1(5), CBS(1), CTH(3), GGT1(4), HEMK1(2), LCMT1(1), LCMT2(10), MARS(11), MARS2(1), MAT1A(2), MAT2B(2), METTL2B(4), METTL6(1), PAPSS1(2), PAPSS2(2), PRMT2(5), PRMT3(3), PRMT5(6), PRMT6(2), PRMT7(3), PRMT8(4), SCLY(4), SEPHS1(2), SEPHS2(3), WBSCR22(2) 34674337 88 63 87 17 16 26 21 10 14 1 0.0378 1.000 1.000 208 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(1), AOC2(6), AOC3(3), CES1(4), ESD(2) 8180767 16 12 16 7 1 3 7 4 1 0 0.825 1.000 1.000 209 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(1), LDLR(6), NR0B2(2), NR1H3(2), NR1H4(4), RXRA(2) 7274062 17 17 17 8 6 4 2 4 1 0 0.871 1.000 1.000 210 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(2), CLOCK(3), CRY1(2), CRY2(3), CSNK1E(4), PER1(10) 11816993 24 19 24 7 2 9 4 6 3 0 0.729 1.000 1.000 211 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(3), ADSS(3), IMPDH1(2), POLB(1), POLD1(5), POLG(7), PRPS2(1), RRM1(4), SRM(4) 17643206 30 27 29 8 7 7 7 1 7 1 0.589 1.000 1.000 212 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(1), B3GALNT1(2), B3GALT5(2), FUT1(1), GBGT1(2), GLA(5), HEXA(3), HEXB(3), NAGA(1), ST3GAL1(2), ST3GAL2(2), ST8SIA1(1) 14706593 25 23 25 7 5 10 2 5 3 0 0.529 1.000 1.000 213 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(3), ADORA2A(4), ADORA3(1), P2RY1(4), P2RY2(1), P2RY6(1) 7780486 14 13 14 6 5 0 6 3 0 0 0.667 1.000 1.000 214 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(2), HADH(2), HADHA(3), HADHB(3), HSD17B10(1), HSD17B4(8), PPT1(1), PPT2(3) 11907818 23 20 23 7 4 10 6 2 1 0 0.593 1.000 1.000 215 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(3), ACYP1(2), EHHADH(4), GCDH(2), HADHA(3), SDHB(2) 11260298 16 15 16 5 2 6 3 5 0 0 0.612 1.000 1.000 216 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR1(1), MTMR2(2), MTMR6(3), NFS1(1), THTPA(3), TPK1(2) 9205688 12 11 12 5 2 7 1 1 1 0 0.907 1.000 1.000 217 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(4), GPD2(3), NDUFA1(2), SDHB(2), SDHD(1), UQCRC1(1) 9409288 13 12 13 5 3 1 2 6 1 0 0.772 1.000 1.000 218 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CSF3(2), EPO(1), FLT3(4), IL11(1), IL1A(1), IL3(1), IL6(2), KITLG(3), TGFB1(2), TGFB2(1), TGFB3(1) 12163100 19 19 19 8 5 2 5 4 3 0 0.850 1.000 1.000 219 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(3), CHAT(2), CHKA(1), PCYT1A(2), PDHA1(2), PDHA2(4), PEMT(1), SLC18A3(3) 9255670 18 16 18 6 5 3 4 4 2 0 0.632 1.000 1.000 220 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 11 BPNT1(2), CHST11(1), PAPSS1(2), PAPSS2(2), SULT1A1(1), SULT1A2(2), SULT1E1(4), SULT2B1(2), SUOX(4) 12337622 20 18 20 8 5 4 4 4 3 0 0.868 1.000 1.000 221 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), FOSL2(1), IFNAR1(2), IFNAR2(1), MAPK8(2), NFKB1(5), RELA(3), TNFRSF11A(2), TRAF6(4) 15288700 21 21 21 8 5 4 3 4 5 0 0.825 1.000 1.000 222 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPL(1), ALPP(3), ALPPL2(2), FPGS(4), GCH1(1) 8298532 11 10 11 5 4 1 3 2 1 0 0.770 1.000 1.000 223 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(3), AMD1(2), BHMT(1), CBS(1), CTH(3), DNMT1(11), DNMT3A(8), DNMT3B(3), MARS(11), MARS2(1), MAT1A(2), MAT2B(2), MTAP(1), MTR(5), SRM(4), TAT(3) 29374078 61 50 60 13 11 15 13 10 10 2 0.163 1.000 1.000 224 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(9), ACO1(4), ACO2(5), ACSS1(1), ACSS2(2), FH(3), IDH1(5), MDH1(1), SUCLA2(1) 19205318 31 26 31 9 4 6 9 7 5 0 0.509 1.000 1.000 225 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(4), ASPH(9), CREB1(2), EDN1(5), EP300(13), EPO(1), HIF1A(4), JUN(3), LDHA(3), NOS3(3), P4HB(2) 24022612 49 39 49 10 4 12 11 10 12 0 0.427 1.000 1.000 226 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(5), PGAP1(10), PIGA(5), PIGB(2), PIGG(7), PIGL(2), PIGM(3), PIGN(4), PIGO(3), PIGQ(4), PIGS(2), PIGT(5), PIGV(2), PIGW(3), PIGZ(3) 35444282 61 47 61 11 8 19 14 14 6 0 0.0383 1.000 1.000 227 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(2), IL2RG(2), IL4(1), IL4R(6), IRS1(4), JAK1(11), JAK3(8), RPS6KB1(4), SHC1(2), STAT6(8) 19962253 48 38 48 11 5 13 12 8 9 1 0.308 1.000 1.000 228 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(5), CTSD(1), ESR1(7), GREB1(6), MTA3(2), PDZK1(1), TUBA8(1) 14243092 23 22 23 7 5 9 3 2 4 0 0.455 1.000 1.000 229 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(5), F2(2), F2R(4), F5(26), F7(2), FGA(7), FGB(1), FGG(7), PROC(3), PROS1(4), SERPINC1(6), TFPI(4) 23248233 71 57 71 16 9 21 18 15 8 0 0.299 1.000 1.000 230 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(1), ACAA2(2), ACAT1(3), EHHADH(4), HADHA(3), HADHB(3) 12158591 16 16 16 5 2 4 5 4 1 0 0.628 1.000 1.000 231 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 21 AOX1(7), BST1(3), CD38(3), ENPP1(7), ENPP3(6), NADK(1), NADSYN1(6), NMNAT1(2), NMNAT2(3), NNT(6), NT5C1A(2), NT5C1B(6), NT5C2(3), NT5C3(4), NT5E(6), NUDT12(2) 30216915 67 54 67 14 7 19 13 17 11 0 0.184 1.000 1.000 232 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 12 FUCA1(1), FUCA2(3), GLB1(4), HEXA(3), HEXB(3), LCT(17), MAN2C1(6), MANBA(5), NEU1(1), NEU3(2) 21657730 45 40 45 11 5 17 8 8 7 0 0.380 1.000 1.000 233 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), ASNS(3), CA1(3), CA12(1), CA14(4), CA2(2), CA4(2), CA5B(3), CA6(1), CA9(5), CPS1(12), CTH(3), GLS(5), GLUD1(2), GLUL(3), HAL(7) 27192974 57 49 57 12 6 12 17 11 11 0 0.224 1.000 1.000 234 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 23 ARHGDIB(1), CASP10(2), CASP3(1), CASP6(2), CASP7(2), CFLAR(1), DAXX(2), DFFA(4), DFFB(2), FAF1(7), JUN(3), LMNA(4), LMNB1(2), LMNB2(3), MAP3K7(3), MAPK8(2), PAK1(4), PAK2(2), PRKDC(24), PTPN13(16), RIPK2(2), SPTAN1(13) 52256832 102 71 101 15 14 30 18 18 22 0 0.0469 1.000 1.000 235 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 DLL1(5), FURIN(3), NOTCH1(8), PSEN1(2) 11132308 18 17 18 6 4 1 8 2 3 0 0.720 1.000 1.000 236 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 31 ABP1(1), ADH1A(1), ADH1C(4), ADH4(1), ADH6(2), ADH7(3), ADHFE1(2), ALDH1A3(7), ALDH3A1(3), ALDH3B2(4), AOC2(6), AOC3(3), AOX1(7), COMT(1), DBH(6), DCT(4), DDC(4), FAH(3), GOT1(2), GOT2(1), GSTZ1(1), HGD(4), HPD(4), MAOA(2), MAOB(4), PNMT(1), TAT(3), TH(2), TPO(8), TYR(5) 43642420 99 74 98 21 24 18 25 16 16 0 0.0825 1.000 1.000 237 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(2), CYP2A13(8), CYP2A6(1), CYP2A7(1), NAT1(2), XDH(9) 11669208 23 20 23 9 4 4 5 7 3 0 0.815 1.000 1.000 238 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(8), G6PD(4), GCLC(2), GCLM(2), GGT1(4), GPX2(1), GPX3(1), GPX4(1), GPX5(1), GSR(4), GSS(3), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTK1(3), GSTM4(2), GSTM5(1), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(5), MGST3(2), TXNDC12(1) 28918353 57 44 56 10 6 12 14 15 10 0 0.0717 1.000 1.000 239 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(3), GCK(3), GFPT1(3), GNE(5), GNPDA2(2), HEXA(3), HEXB(3), HK1(3), HK2(5), HK3(5), PGM3(2), UAP1(3) 24432148 40 35 40 9 7 13 5 11 4 0 0.258 1.000 1.000 240 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 22 ARSA(2), ARSB(3), ARSE(4), ASAH1(1), GAL3ST1(5), GALC(1), GBA(2), GLA(5), GLB1(4), LCT(17), NEU1(1), NEU3(2), PPAP2A(2), PPAP2C(1), SMPD1(2), SMPD2(2), SPTLC1(4), SPTLC2(6), UGCG(1) 32137678 65 52 63 14 14 17 11 18 5 0 0.131 1.000 1.000 241 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(9), AARS2(5), ABAT(7), ACY3(3), ADSL(3), ADSS(3), ADSSL1(1), AGXT(1), AGXT2(2), ASL(4), ASNS(3), ASPA(4), ASS1(1), CAD(17), CRAT(8), DARS(4), DARS2(2), DDO(1), DLAT(2), DLD(1), GAD1(3), GAD2(3), GOT1(2), GOT2(1), GPT(2), GPT2(3), NARS(1), NARS2(2), PC(10), PDHA1(2), PDHA2(4), PDHB(1) 53634764 115 87 115 20 20 29 32 15 19 0 0.0118 1.000 1.000 242 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(5), ATP6V0C(1), CAT(2), EPX(4), LPO(4), MPO(5), PRDX1(3), PRDX2(1), PRDX5(4), SHMT1(1), SHMT2(4), TPO(8) 16839445 42 37 42 11 11 9 5 8 9 0 0.380 1.000 1.000 243 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 21 ABP1(1), ALDH1A3(7), ALDH3A1(3), ALDH3B2(4), AOC2(6), AOC3(3), DDC(4), EPX(4), GOT1(2), GOT2(1), HPD(4), LPO(4), MAOA(2), MAOB(4), MPO(5), PRDX1(3), PRDX2(1), PRDX5(4), TAT(3), TPO(8) 30125091 73 54 72 17 16 14 12 16 15 0 0.212 1.000 1.000 244 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 21 ATM(23), ATR(13), BRCA1(14), CCNB1(3), CDC25A(1), CDC25B(3), CDC25C(6), CDC34(1), CDKN1A(1), CHEK1(2), CHEK2(6), EP300(13), MDM2(3), MYT1(10), PRKDC(24), RPS6KA1(7), WEE1(4) 61317892 134 106 132 22 17 37 20 25 35 0 0.0873 1.000 1.000 245 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR1(3), CCR2(7), CCR3(2), CCR4(1), CCR5(1), CCR7(4), CD28(2), CD4(4), CXCR3(6), CXCR4(3), IFNG(2), IFNGR1(2), IL12B(2), IL12RB1(7), IL12RB2(4), IL18R1(4), IL4(1), IL4R(6), TGFB1(2), TGFB2(1), TGFB3(1) 29252883 65 47 65 17 6 14 13 21 11 0 0.375 1.000 1.000 246 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 12 CNR1(1), CNR2(1), DNMT1(11), PTAFR(1), PTGDR(2), PTGER2(2), PTGER4(1), PTGFR(1) 14353833 20 18 20 9 5 4 4 3 3 1 0.755 1.000 1.000 247 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 AKT1(2), APAF1(11), ATM(23), BAD(1), BAX(3), BCL2L1(1), BID(4), CASP3(1), CASP6(2), CASP7(2), CASP9(3), EIF2S1(3), PRKCA(4), PTK2(7), STAT1(4), TLN1(16) 38409307 87 67 86 17 12 33 10 12 20 0 0.187 1.000 1.000 248 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(1), ALOX12(7), ALOX15(4), ALOX5(3), CBR1(3), CYP4F2(3), CYP4F3(3), EPX(4), GGT1(4), LPO(4), LTA4H(2), MPO(5), PLA2G1B(1), PLA2G2A(1), PLA2G2E(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PRDX1(3), PRDX2(1), PRDX5(4), PTGDS(4), PTGES2(2), PTGIS(4), PTGS1(5), PTGS2(5), TBXAS1(3), TPO(8) 39598131 96 71 96 18 18 23 19 19 17 0 0.0279 1.000 1.000 249 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(5), CS(2), FH(3), MDH1(1), OGDH(7), SUCLA2(1) 13832182 19 17 19 7 2 7 4 3 3 0 0.725 1.000 1.000 250 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), ASNS(3), CA1(3), CA12(1), CA13(1), CA14(4), CA2(2), CA4(2), CA5B(3), CA6(1), CA9(5), CPS1(12), CTH(3), GLS(5), GLUD1(2), GLUD2(3), GLUL(3), HAL(7) 30311351 61 53 61 13 8 13 17 12 11 0 0.215 1.000 1.000 251 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 14 FUCA1(1), FUCA2(3), GLB1(4), HEXA(3), HEXB(3), LCT(17), MAN2B1(6), MAN2B2(9), MAN2C1(6), MANBA(5), NEU1(1), NEU3(2) 26861042 60 51 60 15 12 19 10 10 9 0 0.278 1.000 1.000 252 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 21 BCAR1(6), CRK(1), CXCR4(3), GNAI1(2), GNAQ(1), GNB1(2), HRAS(2), MAP2K1(5), MAPK1(1), MAPK3(1), NFKB1(5), PIK3C2G(8), PLCG1(8), PRKCA(4), PTK2(7), PTK2B(7), RAF1(4), RELA(3) 34407455 70 57 69 13 15 20 8 15 11 1 0.0955 1.000 1.000 253 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(3), BHMT(1), CBS(1), CTH(3), DNMT1(11), DNMT3A(8), DNMT3B(3), MARS(11), MARS2(1), MAT1A(2), MAT2B(2), MTR(5) 24734248 51 40 50 12 10 13 9 9 8 2 0.262 1.000 1.000 254 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 14 AKT1(2), AKT2(5), AKT3(4), CDKN1A(1), ELK1(4), HRAS(2), MAP2K1(5), MAP2K2(2), NGFR(1), NTRK1(8), PIK3CD(6), SHC1(2), SOS1(5) 19075377 47 42 47 12 9 11 8 10 9 0 0.318 1.000 1.000 255 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 37 APAF1(11), BAK1(3), BAX(3), BCL2L1(1), BID(4), BIRC2(3), BIRC3(4), CASP2(3), CASP3(1), CASP6(2), CASP7(2), CASP9(3), FAS(1), FASLG(2), JUN(3), MAPK10(4), MCL1(1), MDM2(3), MYC(1), NFKB1(5), NFKBIA(3), PARP1(6), PRF1(2), RELA(3), RIPK1(5), TNFRSF1A(4), TNFRSF1B(2), TRAF1(2), TRAF2(1) 44134847 88 61 87 15 17 32 15 7 17 0 0.0396 1.000 1.000 256 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 20 CHUK(8), IKBKB(6), IL1A(1), IL1R1(1), IRAK1(5), MAP3K7(3), MYD88(1), NFKB1(5), NFKBIA(3), RELA(3), RIPK1(5), TLR4(15), TNFAIP3(3), TNFRSF1A(4), TNFRSF1B(2), TRAF6(4) 29712189 69 51 67 14 12 20 11 11 15 0 0.147 1.000 1.000 257 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 23 AKT1(2), AKT2(5), AKT3(4), BAD(1), GSK3A(5), GSK3B(2), IL4R(6), IRS1(4), JAK1(11), JAK3(8), MAP4K1(10), MAPK1(1), MAPK3(1), PDK1(2), PIK3CD(6), PPP1R13B(4), RAF1(4), SHC1(2), SOS1(5), SOS2(6), STAT6(8) 43541066 97 75 97 19 15 22 18 20 21 1 0.0754 1.000 1.000 258 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(5), CAT(2), EPX(4), LPO(4), MPO(5), MTHFR(6), SHMT1(1), SHMT2(4), TPO(8) 16454255 39 32 39 10 11 11 3 7 7 0 0.323 1.000 1.000 259 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(2), JAK1(11), JAK2(7), JAK3(8), PIAS1(3), PIAS3(3), PTPRU(10), REG1A(1), SOAT1(2) 19634327 47 39 47 11 9 9 11 7 10 1 0.387 1.000 1.000 260 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(2), MMP14(4), MMP2(4), MMP9(3), RECK(2), TIMP1(2), TIMP3(3) 10797328 20 17 20 9 4 6 3 6 1 0 0.861 1.000 1.000 261 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(3), ELK1(4), FOS(1), HRAS(2), IL2RA(2), IL2RB(3), IL2RG(2), JAK1(11), JAK3(8), JUN(3), LCK(2), MAP2K1(5), MAPK3(1), MAPK8(2), RAF1(4), SHC1(2), SOS1(5), STAT5A(6), STAT5B(5), SYK(4) 33067979 75 61 75 15 15 16 13 16 15 0 0.0932 1.000 1.000 262 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 18 AKT1(2), BCR(3), CRKL(1), FOS(1), HRAS(2), JAK2(7), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(2), MYC(1), RAF1(4), SOS1(5), STAT1(4), STAT5A(6), STAT5B(5) 28412331 52 49 52 10 11 13 5 13 10 0 0.147 1.000 1.000 263 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 14 CREBBP(15), EP300(13), IL2RG(2), IL7(1), IL7R(4), JAK1(11), JAK3(8), LCK(2), NMI(2), PTK2B(7), STAT5A(6), STAT5B(5) 34669884 76 59 76 15 15 16 14 15 16 0 0.126 1.000 1.000 264 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(6), GABARAP(2), GABRA1(4), GABRA2(3), GABRA3(6), GABRA4(7), GABRA5(4), GABRA6(6), GPHN(5), NSF(3), SRC(1), UBQLN1(2) 17314468 49 40 49 13 9 18 9 9 4 0 0.374 1.000 1.000 265 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 13 AKT1(2), BAD(1), HRAS(2), IGF1R(7), IRS1(4), MAP2K1(5), MAPK1(1), MAPK3(1), RAF1(4), SHC1(2), SOS1(5) 20630531 34 30 34 9 4 13 4 8 5 0 0.529 1.000 1.000 266 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(7), CD38(3), ENPP1(7), ENPP3(6), NADSYN1(6), NMNAT1(2), NMNAT2(3), NNT(6), NT5E(6) 20917447 46 39 46 12 5 14 8 11 8 0 0.452 1.000 1.000 267 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(3), GALNS(2), GLB1(4), GNS(3), GUSB(6), HEXA(3), HEXB(3), IDS(3), IDUA(1), LCT(17), NAGLU(2) 20176770 47 42 47 13 8 13 7 13 6 0 0.511 1.000 1.000 268 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(5), ALDOB(3), ALDOC(2), FBP1(2), G6PD(4), GPI(3), H6PD(3), PFKM(8), PFKP(7), PGD(4), PGLS(2), PGM1(5), PGM3(2), PRPS2(1), RBKS(1), TAL1(1), TALDO1(2), TKT(3) 27853212 58 45 56 14 10 13 8 16 11 0 0.265 1.000 1.000 269 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(2), IL6(2), IL6R(5), JAK1(11), JAK2(7), JAK3(8), PIAS3(3), PTPRU(10), REG1A(1), SRC(1), STAT3(5) 21566510 55 43 55 13 10 7 13 11 13 1 0.362 1.000 1.000 270 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 23 ARHGDIB(1), BAG4(1), CASP2(3), CASP3(1), DFFA(4), DFFB(2), JUN(3), LMNA(4), LMNB1(2), LMNB2(3), MADD(15), MAP3K7(3), MAPK8(2), PAK1(4), PAK2(2), PRKDC(24), RIPK1(5), SPTAN1(13), TNFRSF1A(4), TRAF2(1) 46683370 97 70 95 17 17 28 19 14 19 0 0.0715 1.000 1.000 271 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(2), F2R(4), GNAI1(2), GNB1(2), HRAS(2), ITGA1(6), ITGB1(5), MAP2K1(5), MAPK1(1), MAPK3(1), PLA2G4A(7), PLCB1(13), PRKCA(4), PTGS1(5), PTK2(7), RAF1(4), SRC(1), SYK(4), TBXAS1(3) 34813315 78 55 78 15 14 19 19 18 8 0 0.0928 1.000 1.000 272 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(3), APAF1(11), CASP3(1), CASP9(3), DAXX(2), FAS(1), FASLG(2), IL1A(1), MAPKAPK2(1), MAPKAPK3(2) 15453534 27 22 27 9 4 11 5 3 3 1 0.737 1.000 1.000 273 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(3), ALDOA(5), ALDOB(3), ALDOC(2), FBP1(2), FPGT(1), GCK(3), GMDS(2), GMPPA(1), HK1(3), HK2(5), HK3(5), KHK(4), MPI(2), PFKFB3(4), PFKFB4(3), PFKM(8), PFKP(7), PMM1(2), SORD(2), TPI1(2) 34500029 69 55 67 16 12 13 10 22 12 0 0.195 1.000 1.000 274 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 34 BET1(1), BET1L(1), BNIP1(1), GOSR1(2), SNAP23(2), SNAP25(4), SNAP29(1), STX10(3), STX11(2), STX12(1), STX16(1), STX17(3), STX19(3), STX2(3), STX3(3), STX4(3), STX6(4), STX8(1), TSNARE1(4), USE1(2), VAMP1(1), VAMP2(1), VAMP3(2), VAMP4(1), VAMP5(1), VAMP7(2), VTI1A(1), VTI1B(2) 23398571 56 50 56 13 9 18 11 6 12 0 0.290 1.000 1.000 275 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 30 CD14(1), CHUK(8), ELK1(4), FOS(1), IKBKB(6), IRAK1(5), JUN(3), MAP2K3(3), MAP2K6(1), MAP3K7(3), MAPK14(2), MAPK8(2), MYD88(1), NFKB1(5), NFKBIA(3), PPARA(4), RELA(3), TIRAP(1), TLR10(3), TLR2(3), TLR3(7), TLR4(15), TLR7(9), TLR9(2), TRAF6(4) 46739982 99 77 98 20 16 30 16 16 21 0 0.0969 1.000 1.000 276 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(3), ELK1(4), EPO(1), EPOR(4), FOS(1), HRAS(2), JAK2(7), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(2), PLCG1(8), PTPN6(2), RAF1(4), SHC1(2), SOS1(5), STAT5A(6), STAT5B(5) 30754287 65 57 65 14 15 19 5 11 15 0 0.181 1.000 1.000 277 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(4), CD28(2), CD3E(3), CD3G(3), CD8A(3), ICAM1(2), ITGAL(5), ITGB2(8), PTPRC(8), THY1(1) 15051669 39 32 39 12 3 12 10 8 6 0 0.532 1.000 1.000 278 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(10), GABBR1(3), GPRC5A(1), GPRC5B(1), GPRC5C(3), GPRC5D(1), GRM1(9), GRM2(3), GRM3(10), GRM4(3), GRM5(4), GRM7(4), GRM8(5) 27403867 57 49 57 15 14 15 13 8 7 0 0.134 1.000 1.000 279 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 26 BCAR1(6), CALM2(2), CRKL(1), GNAQ(1), HRAS(2), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAPK1(1), MAPK14(2), MAPK3(1), MAPK8(2), PAK1(4), PLCG1(8), PRKCA(4), PTK2B(7), RAF1(4), SHC1(2), SOS1(5), SRC(1), SYT1(2) 35113951 68 58 68 14 13 20 8 13 13 1 0.162 1.000 1.000 280 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CSNK2A1(3), ELK1(4), FOS(1), HRAS(2), IL6(2), IL6R(5), IL6ST(9), JAK1(11), JAK2(7), JAK3(8), JUN(3), MAP2K1(5), MAPK3(1), PTPN11(1), RAF1(4), SHC1(2), SOS1(5), SRF(1), STAT3(5) 33507537 79 61 79 17 13 14 16 18 18 0 0.219 1.000 1.000 281 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(8), DYRK1B(1), GLI2(12), GLI3(11), GSK3B(2), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), SHH(1), SMO(5), SUFU(3) 21773272 58 47 58 16 12 17 11 8 10 0 0.387 1.000 1.000 282 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(23), ATR(13), BRCA1(14), BRCA2(17), CHEK1(2), CHEK2(6), FANCA(8), FANCC(4), FANCD2(10), FANCE(2), FANCF(2), FANCG(4), HUS1(2), MRE11A(8), RAD1(1), RAD17(3), RAD50(6), RAD51(2), RAD9A(1) 62462060 128 99 127 21 14 52 12 23 27 0 0.110 1.000 1.000 283 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 19 AKT1(2), BAD(1), BCL2L1(1), CASP9(3), CHUK(8), ELK1(4), HRAS(2), MAP2K1(5), MAPK3(1), NFKB1(5), RAF1(4), RALA(1), RALBP1(3), RALGDS(2), RELA(3), RHOA(6) 21954724 51 43 50 13 13 16 5 11 6 0 0.364 1.000 1.000 284 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 45 APAF1(11), BAD(1), BAX(3), BCL2A1(1), BCL2L1(1), BCL2L2(1), BOK(1), CASP1(3), CASP10(2), CASP2(3), CASP3(1), CASP4(1), CASP6(2), CASP7(2), CASP9(3), CD40(2), CD40LG(1), DAXX(2), DFFA(4), DFFB(2), FAS(1), FASLG(2), IKBKE(6), LTA(2), MCL1(1), NFKB1(5), NFKBIA(3), NGFR(1), NR3C1(3), NTRK1(8), PTPN13(16), RIPK1(5), TFG(2), TNFRSF1A(4), TNFRSF1B(2), TRAF1(2), TRAF2(1), TRAF3(3), TRAF6(4) 59760785 118 77 116 22 16 39 19 18 25 1 0.0597 1.000 1.000 285 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(3), GALNS(2), GLB1(4), GNS(3), GUSB(6), HEXA(3), HEXB(3), HGSNAT(6), HPSE(6), HPSE2(5), HYAL2(3), IDS(3), IDUA(1), LCT(17), NAGLU(2), SPAM1(4) 28945867 71 62 72 19 12 21 10 17 11 0 0.419 1.000 1.000 286 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 22 IMPA1(3), INPP1(1), INPP4A(5), INPP4B(7), INPP5A(2), INPPL1(6), ITPKA(1), ITPKB(8), OCRL(8), PIK3C2A(5), PIK3C2B(12), PIK3C2G(8), PIK3CB(8), PIK3CG(5), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PLCD1(3), PLCG1(8), PLCG2(8) 60950092 136 96 135 26 22 40 19 23 31 1 0.0470 1.000 1.000 287 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(4), ACOX3(5), FADS2(7), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2) 14918453 35 30 35 10 2 12 10 9 2 0 0.511 1.000 1.000 288 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(5), ANXA3(3), ANXA4(3), ANXA5(1), ANXA6(5), CYP11A1(1), EDN1(5), EDNRA(3), EDNRB(2), HPGD(1), HSD11B1(3), HSD11B2(2), PLA2G4A(7), PTGDR(2), PTGDS(4), PTGER2(2), PTGER4(1), PTGFR(1), PTGIS(4), PTGS1(5), PTGS2(5), S100A6(1), TBXAS1(3) 29076974 69 50 69 17 12 20 9 16 12 0 0.334 1.000 1.000 289 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(8), CREBBP(15), DUSP1(1), EP300(13), IKBKB(6), IL8(1), MAP2K3(3), MAP2K6(1), MAP3K7(3), MAPK14(2), MYD88(1), NFKB1(5), NFKBIA(3), NR3C1(3), RELA(3), TGFBR1(4), TGFBR2(4), TLR2(3) 42126209 79 59 79 16 16 19 11 13 20 0 0.176 1.000 1.000 290 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 22 GHR(5), HRAS(2), INSR(11), IRS1(4), JAK2(7), MAP2K1(5), MAPK1(1), MAPK3(1), PLCG1(8), PRKCA(4), PTPN6(2), RAF1(4), RPS6KA1(7), SHC1(2), SLC2A4(3), SOS1(5), SRF(1), STAT5A(6), STAT5B(5) 40921998 83 66 82 17 14 29 6 13 21 0 0.117 1.000 1.000 291 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(3), ARG1(3), ARG2(2), ASL(4), ASS1(1), CKB(1), CKM(1), CKMT1A(1), CKMT1B(1), CKMT2(5), CPS1(12), DAO(1), EPRS(11), GAMT(1), GATM(3), GLUD1(2), GLUD2(3), GOT1(2), GOT2(1), LAP3(3), NOS1(13), NOS3(3), OAT(2), OTC(3), P4HA1(3), P4HA2(5), P4HA3(4), PARS2(2), PRODH(2), PYCR1(1), PYCR2(2), PYCRL(1), RARS(5), RARS2(3) 50673716 110 80 109 22 22 30 34 13 11 0 0.0391 1.000 1.000 292 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(1), ACY1(2), ADC(2), AGMAT(4), ALDH18A1(4), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), AMD1(2), AOC2(6), AOC3(3), ARG1(3), ARG2(2), ASL(4), ASS1(1), CPS1(12), GATM(3), MAOA(2), MAOB(4), NAGS(1), OTC(3), SAT1(3), SAT2(2), SRM(4) 41605856 85 61 84 19 9 15 27 20 14 0 0.158 1.000 1.000 293 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(5), CHIA(3), CHIT1(3), CMAS(3), CTBS(1), CYB5R1(4), GFPT1(3), GFPT2(9), GNE(5), GNPDA2(2), GNPNAT1(2), HEXA(3), HEXB(3), HK1(3), HK2(5), HK3(5), MTMR1(1), MTMR2(2), MTMR6(3), NAGK(2), NANS(1), NPL(2), PGM3(2), UAP1(3) 41264196 75 57 74 16 11 24 13 16 11 0 0.184 1.000 1.000 294 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(4), DHRS3(1), DHRS7(4), DHRSX(1), ESCO1(4), ESCO2(1), PNPLA3(3), SH3GLB1(2) 23510977 20 17 20 6 1 8 1 7 2 1 0.747 1.000 1.000 295 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 20 CSNK2A1(3), FOS(1), HRAS(2), JAK2(7), JUN(3), MAP2K1(5), MAPK3(1), MPL(2), PLCG1(8), PRKCA(4), RAF1(4), RASA1(2), SHC1(2), SOS1(5), STAT1(4), STAT3(5), STAT5A(6), STAT5B(5), THPO(3) 37493833 72 61 72 15 14 17 8 16 17 0 0.224 1.000 1.000 296 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 29 DUSP1(1), GORASP1(1), MAP2K7(1), MAPK1(1), MAPK10(4), MAPK13(1), MAPK14(2), MAPK3(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(8), MAPK9(1), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), PIK3CD(6), SYT1(2), TRAF2(1), TRAF3(3), TRAF5(3), TRAF6(4) 38421184 62 53 62 13 16 13 9 12 11 1 0.155 1.000 1.000 297 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 18 AKT1(2), EIF4A1(2), EIF4A2(10), EIF4B(2), EIF4G1(9), EIF4G2(2), EIF4G3(6), MKNK1(2), PDK2(1), PDPK1(2), PPP2CA(3), RPS6(4), RPS6KB1(4), TSC1(5), TSC2(8) 32778571 62 51 61 13 12 26 6 10 8 0 0.247 1.000 1.000 298 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 35 AKT1(2), ATF2(4), DLD(1), DUSP10(9), DUSP4(1), GAB1(2), GCK(3), IL1R1(1), JUN(3), MAP2K5(1), MAP2K7(1), MAP3K10(3), MAP3K11(5), MAP3K12(7), MAP3K13(10), MAP3K2(3), MAP3K3(1), MAP3K4(8), MAP3K5(12), MAP3K7(3), MAP3K9(6), MAPK10(4), MAPK7(4), MAPK8(2), MAPK9(1), MYEF2(3), NFATC3(9), NR2C2(2), PAPPA(13), SHC1(2), TRAF6(4), ZAK(6) 64273135 136 96 134 26 22 28 18 26 42 0 0.0998 1.000 1.000 299 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(5), ALDOB(3), ALDOC(2), DERA(2), FBP1(2), G6PD(4), GPI(3), H6PD(3), PFKL(1), PFKM(8), PFKP(7), PGD(4), PGLS(2), PGM1(5), PGM3(2), PRPS2(1), RBKS(1), TALDO1(2), TKT(3), TKTL1(3), TKTL2(3) 33744267 66 51 64 17 10 14 10 17 15 0 0.351 1.000 1.000 300 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(5), CS(2), DLAT(2), DLD(1), DLST(3), FH(3), IDH3A(2), IDH3B(2), IDH3G(1), MDH1(1), OGDH(7), PC(10), PDHA1(2), PDHA2(4), PDHB(1), PDHX(3), PDK1(2), PDK2(1), PDK4(4), PDP2(2), SDHB(2), SDHD(1), SUCLA2(1), SUCLG2(1) 40969682 63 50 63 14 14 15 14 15 5 0 0.129 1.000 1.000 301 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(4), AADAC(5), ABAT(7), ACADS(2), ACAT1(3), ACSM1(4), AKR1B10(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH5A1(2), ALDH9A1(1), BDH1(1), DDHD1(4), EHHADH(4), GAD1(3), GAD2(3), HADH(2), HADHA(3), HMGCS1(6), HMGCS2(3), HSD17B10(1), HSD17B4(8), HSD3B7(1), ILVBL(5), L2HGDH(2), OXCT1(5), OXCT2(5), PDHA1(2), PDHA2(4), PDHB(1), PLA1A(3), PPME1(2), RDH11(4), RDH12(2), RDH13(2), RDH14(2) 58178755 123 91 120 28 21 32 24 29 17 0 0.106 1.000 1.000 302 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 47 APAF1(11), ARHGDIB(1), BAG4(1), BID(4), BIRC2(3), BIRC3(4), CASP2(3), CASP3(1), CASP6(2), CASP7(2), CASP9(3), CFLAR(1), CHUK(8), DAXX(2), DFFA(4), DFFB(2), GSN(2), LMNA(4), LMNB1(2), LMNB2(3), MAP2K7(1), MAP3K5(12), MAPK8(2), MDM2(3), NFKB1(5), NFKBIA(3), NUMA1(8), PAK2(2), PRKCD(5), PRKDC(24), PSEN1(2), PSEN2(4), PTK2(7), RASA1(2), RELA(3), RIPK1(5), SPTAN1(13), TNFRSF1A(4), TNFRSF1B(2), TRAF1(2), TRAF2(1) 89740755 173 114 170 27 36 50 32 23 32 0 0.00439 1.000 1.000 303 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 23 ATF2(4), BCR(3), BLNK(1), ELK1(4), FOS(1), HRAS(2), JUN(3), LYN(6), MAP2K1(5), MAPK1(1), MAPK3(1), MAPK8IP3(8), PAPPA(13), RPS6KA1(7), RPS6KA3(8), SHC1(2), SOS1(5), SYK(4), VAV1(6), VAV2(3), VAV3(7) 40548007 94 69 93 22 20 21 16 20 17 0 0.199 1.000 1.000 304 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 25 AKT1(2), AKT2(5), AKT3(4), CISH(2), IARS(8), IL13RA1(1), IL2RG(2), IL4(1), IL4R(6), INPP5D(4), JAK1(11), JAK2(7), JAK3(8), NR0B2(2), PI3(1), PPP1R13B(4), RPS6KB1(4), SERPINA4(4), SHC1(2), SOS1(5), SOS2(6), SRC(1), STAT6(8), TYK2(8) 48886681 106 83 104 23 17 23 21 19 24 2 0.187 1.000 1.000 305 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 36 ANKHD1(15), EEF1A2(3), EEF1B2(2), EEF1D(3), EEF1G(1), EEF2(5), EEF2K(6), EIF1AX(3), EIF2AK1(5), EIF2AK2(3), EIF2AK3(4), EIF2B1(3), EIF2B2(2), EIF2B3(2), EIF2B4(3), EIF2B5(4), EIF2S1(3), EIF2S2(3), EIF2S3(2), EIF4A1(2), EIF4A2(10), EIF4G1(9), EIF4G3(6), EIF5(2), EIF5B(5), ETF1(3), GSPT2(5), KIAA0664(7), PABPC1(2), PABPC3(8) 63025230 131 93 131 25 24 42 20 20 25 0 0.0749 1.000 1.000 306 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 19 AKT1(2), EIF4A1(2), EIF4A2(10), EIF4G1(9), EIF4G2(2), EIF4G3(6), GHR(5), IRS1(4), MAPK1(1), MAPK14(2), MAPK3(1), MKNK1(2), PABPC1(2), PDK2(1), PDPK1(2), PRKCA(4), RPS6KB1(4) 32941568 59 45 58 13 9 25 5 8 12 0 0.447 1.000 1.000 307 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 21 ABL1(7), ATM(23), ATR(13), CCND1(1), CCNE1(2), CDC25A(1), CDK2(2), CDK4(1), CDK6(2), CDKN1A(1), CDKN2A(1), E2F1(5), GSK3B(2), HDAC1(5), SKP2(2), TFDP1(3), TGFB1(2), TGFB2(1), TGFB3(1) 37959010 75 61 73 17 12 15 11 17 20 0 0.444 1.000 1.000 308 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 20 ADCY1(5), AKT1(2), BAD(1), BAX(3), BCL2L1(1), CSF2RB(4), IGF1R(7), IL3(1), IL3RA(3), KIT(8), KITLG(3), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2) 25357321 53 36 53 15 9 18 9 6 11 0 0.354 1.000 1.000 309 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 40 ABP1(1), ACY3(3), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH3B2(4), ALDH9A1(1), AMDHD1(4), AOC2(6), AOC3(3), ASPA(4), CARM1(5), CNDP1(7), DDC(4), FTCD(2), HAL(7), HARS(1), HEMK1(2), HNMT(2), LCMT1(1), LCMT2(10), MAOA(2), MAOB(4), METTL2B(4), METTL6(1), PRMT2(5), PRMT3(3), PRMT5(6), PRMT6(2), PRMT7(3), PRMT8(4), PRPS2(1), UROC1(4), WBSCR22(2) 54699107 124 82 123 28 23 32 27 16 25 1 0.109 1.000 1.000 310 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(5), ALDOB(3), ALDOC(2), DLAT(2), DLD(1), ENO2(1), ENO3(2), FBP1(2), G6PC(2), GAPDH(1), GAPDHS(2), GCK(3), GOT1(2), GOT2(1), GPI(3), HK1(3), HK2(5), HK3(5), LDHA(3), LDHC(4), MDH1(1), PC(10), PCK1(5), PDHA1(2), PDHA2(4), PDHB(1), PDHX(3), PFKL(1), PFKM(8), PFKP(7), PGAM2(1), PGK1(6), PGK2(1), PKLR(5), TNFAIP1(1), TPI1(2) 60080758 110 82 108 25 17 29 21 26 17 0 0.0761 1.000 1.000 311 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(2), ALDH18A1(4), ARG1(3), ARG2(2), ASL(4), CKB(1), CKM(1), CKMT1A(1), CKMT1B(1), CKMT2(5), CPS1(12), GAMT(1), GATM(3), GLUD1(2), NAGS(1), OAT(2), OTC(3), PYCR1(1) 24762896 49 40 49 13 5 12 18 9 5 0 0.394 1.000 1.000 312 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 26 CALM2(2), CHUK(8), EGR2(3), EGR3(4), GNAQ(1), MYC(1), NFATC1(5), NFATC2(4), NFKB1(5), NFKBIA(3), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(1), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), RELA(3), SYT1(2), VIP(1), VIPR2(4) 34296829 78 64 78 20 15 21 14 11 17 0 0.315 1.000 1.000 313 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(2), GTF2E1(2), GTF2E2(3), GTF2F1(1), GTF2F2(1), GTF2H1(2), GTF2H3(2), GTF2I(4), GTF2IRD1(1), TAF1(16), TAF13(1), TAF1L(19), TAF2(7), TAF4(3), TAF4B(6), TAF5(4), TAF5L(5), TAF6(3), TAF6L(2), TAF7(1), TAF7L(6), TAF9(2), TBPL2(2) 50872537 95 67 94 18 19 29 13 19 15 0 0.0871 1.000 1.000 314 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(9), ACO1(4), ACO2(5), CLYBL(3), CS(2), DLD(1), DLST(3), FH(3), IDH1(5), IDH3A(2), IDH3B(2), IDH3G(1), MDH1(1), OGDH(7), OGDHL(6), PC(10), PCK1(5), PCK2(4), SDHB(2), SDHD(1), SUCLA2(1), SUCLG2(1) 43162314 78 63 78 19 16 16 21 18 7 0 0.163 1.000 1.000 315 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 31 AKT1(2), BAD(1), BCL2L1(1), CBL(4), CFLAR(1), CRKL(1), E2F1(5), FOS(1), HRAS(2), IL2RA(2), IL2RB(3), IL2RG(2), IRS1(4), JAK1(11), JAK3(8), MAPK1(1), MAPK3(1), MYC(1), NMI(2), PTPN6(2), RAF1(4), RPS6KB1(4), SHC1(2), SOS1(5), STAT5A(6), STAT5B(5), SYK(4) 44288405 85 67 85 19 15 22 14 19 15 0 0.178 1.000 1.000 316 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 36 CALM2(2), CAMK1(1), CAMK1G(5), ELK1(4), FPR1(3), GNB1(2), HRAS(2), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K6(1), MAPK1(1), MAPK14(2), MAPK3(1), NCF1(1), NCF2(7), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), NFKB1(5), NFKBIA(3), PAK1(4), PIK3C2G(8), PLCB1(13), PPP3CA(5), PPP3CB(3), PPP3CC(1), RAF1(4), RELA(3), SYT1(2) 50337950 119 88 118 27 17 36 22 26 18 0 0.133 1.000 1.000 317 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 52 ACYP1(2), ADH1A(1), ADH1C(4), ADH4(1), ADH6(2), ADH7(3), ADHFE1(2), AKR1A1(1), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH3B2(4), ALDH9A1(1), ALDOA(5), ALDOB(3), ALDOC(2), BPGM(1), DLAT(2), DLD(1), ENO2(1), ENO3(2), FBP1(2), G6PC(2), GAPDH(1), GCK(3), GPI(3), HK1(3), HK2(5), HK3(5), LDHA(3), LDHC(4), PDHA1(2), PDHA2(4), PDHB(1), PFKM(8), PFKP(7), PGK1(6), PGM1(5), PGM3(2), PKLR(5), TPI1(2) 68827905 132 97 129 29 22 31 32 26 21 0 0.0624 1.000 1.000 318 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 52 ACYP1(2), ADH1A(1), ADH1C(4), ADH4(1), ADH6(2), ADH7(3), ADHFE1(2), AKR1A1(1), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH3B2(4), ALDH9A1(1), ALDOA(5), ALDOB(3), ALDOC(2), BPGM(1), DLAT(2), DLD(1), ENO2(1), ENO3(2), FBP1(2), G6PC(2), GAPDH(1), GCK(3), GPI(3), HK1(3), HK2(5), HK3(5), LDHA(3), LDHC(4), PDHA1(2), PDHA2(4), PDHB(1), PFKM(8), PFKP(7), PGK1(6), PGM1(5), PGM3(2), PKLR(5), TPI1(2) 68827905 132 97 129 29 22 31 32 26 21 0 0.0624 1.000 1.000 319 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 50 AKR1C3(1), ALOX12(7), ALOX12B(1), ALOX15(4), ALOX15B(5), ALOX5(3), CBR1(3), CYP2B6(5), CYP2C18(2), CYP2C19(6), CYP2C8(3), CYP2C9(3), CYP2E1(2), CYP2U1(1), CYP4A11(8), CYP4A22(2), CYP4F2(3), CYP4F3(3), DHRS4(2), EPHX2(4), GGT1(4), GPX2(1), GPX3(1), GPX4(1), GPX5(1), LTA4H(2), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PTGDS(4), PTGES2(2), PTGIS(4), PTGS1(5), PTGS2(5), TBXAS1(3) 55405602 120 89 120 28 16 32 30 24 18 0 0.0704 1.000 1.000 320 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(12), ARHGEF1(10), GNA12(2), GNA13(1), GNAQ(1), GNB1(2), MYLK(11), PLCB1(13), PPP1R12B(4), PRKCA(4), ROCK1(8) 29874062 68 47 68 16 10 10 15 13 20 0 0.407 1.000 1.000 321 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 31 AKT1(2), AKT2(5), AKT3(4), BAD(1), BTK(7), CDKN2A(1), DAPP1(2), GSK3A(5), GSK3B(2), IARS(8), INPP5D(4), PDK1(2), PPP1R13B(4), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), RPS6KB1(4), SFN(1), SHC1(2), SOS1(5), SOS2(6), TEC(6), YWHAB(2), YWHAG(1), YWHAZ(3) 46812632 97 72 96 22 18 27 13 17 22 0 0.202 1.000 1.000 322 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(5), CSF1R(3), DDX20(4), E2F1(5), E2F4(2), ETS1(3), ETS2(7), ETV3(4), FOS(1), HDAC2(2), HDAC5(6), HRAS(2), JUN(3), NCOR2(8), RBL1(6), SIN3A(10), SIN3B(7) 37458237 78 66 78 20 14 21 8 14 21 0 0.566 1.000 1.000 323 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 19 CSNK2A1(3), ELK1(4), FOS(1), HRAS(2), INSR(11), IRS1(4), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(2), PTPN11(1), RAF1(4), RASA1(2), SHC1(2), SLC2A4(3), SOS1(5), SRF(1) 30065498 54 45 54 14 8 18 4 12 12 0 0.458 1.000 1.000 324 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(12), ACE2(4), AGT(3), AGTR1(4), AGTR2(2), ANPEP(8), CPA3(1), CTSA(3), CTSG(1), ENPEP(9), LNPEP(2), MAS1(2), MME(1), NLN(2), REN(1), THOP1(1) 30065638 56 37 56 15 8 15 7 16 10 0 0.452 1.000 1.000 325 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 187 ACTB(5), ACTN1(6), ACTN2(10), ACTN3(7), ACTN4(7), AKT1(2), AKT2(5), AKT3(4), ARHGAP5(12), BAD(1), BCAR1(6), BIRC2(3), BIRC3(4), BRAF(5), CAPN2(8), CAV1(4), CCND1(1), CCND2(3), CCND3(5), COL11A1(8), COL11A2(5), COL1A1(8), COL1A2(10), COL2A1(4), COL3A1(7), COL4A1(9), COL4A2(9), COL4A4(9), COL4A6(10), COL5A1(13), COL5A2(8), COL5A3(11), COL6A1(3), COL6A2(4), COL6A3(15), COL6A6(14), COMP(5), CRK(1), CRKL(1), CTNNB1(2), DIAPH1(5), DOCK1(8), EGF(5), EGFR(5), ELK1(4), FARP2(10), FIGF(3), FLNA(20), FLNB(14), FLNC(21), FLT1(5), FN1(10), GSK3B(2), HGF(5), HRAS(2), IBSP(5), IGF1R(7), ILK(3), ITGA1(6), ITGA10(10), ITGA11(7), ITGA2(4), ITGA2B(3), ITGA3(1), ITGA4(6), ITGA5(4), ITGA6(4), ITGA7(6), ITGA8(10), ITGA9(7), ITGAV(7), ITGB1(5), ITGB3(4), ITGB4(8), ITGB5(3), ITGB6(6), ITGB7(5), ITGB8(4), JUN(3), KDR(8), LAMA1(18), LAMA2(15), LAMA3(15), LAMA4(9), LAMA5(11), LAMB1(12), LAMB2(9), LAMB3(7), LAMB4(15), LAMC1(8), LAMC2(6), LAMC3(4), MAP2K1(5), MAPK1(1), MAPK10(4), MAPK3(1), MAPK8(2), MAPK9(1), MET(10), MYL5(3), MYL7(1), MYL9(1), MYLK(11), MYLK2(5), MYLPF(1), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PAK7(4), PARVA(3), PARVG(3), PDGFB(2), PDGFRA(6), PDGFRB(7), PDPK1(2), PGF(5), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PIP5K1C(5), PPP1CB(1), PPP1R12A(8), PRKCA(4), PRKCG(3), PTK2(7), RAF1(4), RAP1A(2), RAP1B(1), RAPGEF1(5), RELN(26), RHOA(6), ROCK1(8), ROCK2(9), SHC1(2), SHC2(3), SHC3(1), SHC4(5), SOS1(5), SOS2(6), SPP1(2), SRC(1), THBS1(8), THBS2(2), THBS3(5), THBS4(4), TLN1(16), TLN2(14), TNC(10), TNN(10), TNR(11), TNXB(16), VAV1(6), VAV2(3), VAV3(7), VCL(6), VEGFA(1), VEGFC(2), VTN(3), VWF(11), ZYX(2) 510219091 1017 430 1005 312 200 247 188 191 186 5 0.859 1.000 1.000 326 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 167 ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(6), ADCY7(11), ADCY8(6), ADCY9(14), ADORA2A(4), ADRA1A(6), ADRA1B(1), ADRB2(2), ADRB3(1), AGTR1(4), ATP2A1(11), ATP2A2(5), ATP2A3(2), ATP2B1(14), ATP2B2(10), ATP2B3(10), ATP2B4(11), AVPR1B(5), BDKRB1(4), BDKRB2(4), BST1(3), CACNA1A(16), CACNA1B(14), CACNA1C(17), CACNA1D(18), CACNA1E(28), CACNA1F(17), CACNA1G(13), CACNA1H(11), CACNA1I(5), CACNA1S(8), CALM2(2), CALML6(1), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CAMK4(5), CCKAR(3), CCKBR(2), CD38(3), CHRM1(4), CHRM2(6), CHRM3(3), CHRNA7(1), CYSLTR1(5), CYSLTR2(1), DRD1(1), EDNRA(3), EDNRB(2), EGFR(5), ERBB3(19), ERBB4(14), F2R(4), GNA11(4), GNA14(1), GNAQ(1), GNAS(11), GRIN1(3), GRIN2A(16), GRIN2C(5), GRIN2D(5), GRM1(9), GRM5(4), GRPR(3), HRH1(4), HRH2(4), HTR2A(5), HTR2C(6), HTR5A(4), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), LHCGR(10), MYLK(11), MYLK2(5), NOS1(13), NOS3(3), OXTR(1), P2RX2(3), P2RX3(1), P2RX4(2), P2RX5(4), P2RX7(3), PDE1A(5), PDE1B(5), PDE1C(5), PDGFRA(6), PDGFRB(7), PHKA1(8), PHKA2(13), PHKB(4), PHKG2(1), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PLCD1(3), PLCD3(2), PLCD4(6), PLCE1(15), PLCG1(8), PLCG2(8), PLCZ1(11), PLN(1), PPID(3), PPP3CA(5), PPP3CB(3), PPP3CC(1), PPP3R1(1), PRKACA(4), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(3), PRKX(5), PTAFR(1), PTGER3(4), PTGFR(1), PTK2B(7), RYR1(29), RYR2(53), RYR3(43), SLC25A4(3), SLC25A5(2), SLC25A6(2), SLC8A1(11), SLC8A2(3), SLC8A3(4), SPHK1(1), SPHK2(3), TACR1(2), TACR2(4), TACR3(2), TNNC2(2), TRPC1(9), VDAC1(1), VDAC2(3), VDAC3(1) 385301499 958 423 950 301 216 222 170 220 128 2 0.350 1.000 1.000 327 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 242 ACVR1B(8), ACVR1C(2), AKT1(2), AKT2(5), AKT3(4), ARRB1(1), ARRB2(1), ATF2(4), ATF4(3), BDNF(2), BRAF(5), CACNA1A(16), CACNA1B(14), CACNA1C(17), CACNA1D(18), CACNA1E(28), CACNA1F(17), CACNA1G(13), CACNA1H(11), CACNA1I(5), CACNA1S(8), CACNA2D1(7), CACNA2D2(7), CACNA2D3(9), CACNA2D4(5), CACNB1(3), CACNB2(3), CACNB3(4), CACNB4(2), CACNG1(1), CACNG2(1), CACNG3(3), CACNG4(2), CACNG5(2), CACNG6(1), CACNG7(3), CACNG8(1), CASP3(1), CD14(1), CDC25B(3), CHUK(8), CRK(1), CRKL(1), DAXX(2), DUSP1(1), DUSP10(9), DUSP16(6), DUSP2(1), DUSP4(1), DUSP6(1), DUSP7(3), DUSP9(2), EGF(5), EGFR(5), ELK1(4), ELK4(1), FAS(1), FASLG(2), FGF10(2), FGF11(1), FGF12(1), FGF13(4), FGF14(1), FGF16(2), FGF18(4), FGF20(2), FGF21(1), FGF23(3), FGF3(2), FGF6(2), FGF7(3), FGF8(2), FGF9(1), FGFR1(3), FGFR2(12), FGFR3(4), FGFR4(5), FLNA(20), FLNB(14), FLNC(21), FOS(1), GNA12(2), HRAS(2), IKBKB(6), IL1A(1), IL1R1(1), IL1R2(4), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K5(1), MAP2K6(1), MAP2K7(1), MAP3K10(3), MAP3K12(7), MAP3K13(10), MAP3K2(3), MAP3K3(1), MAP3K4(8), MAP3K5(12), MAP3K6(3), MAP3K7(3), MAP3K8(4), MAP4K1(10), MAP4K2(2), MAP4K3(2), MAP4K4(13), MAPK1(1), MAPK10(4), MAPK13(1), MAPK14(2), MAPK3(1), MAPK7(4), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(8), MAPK9(1), MAPKAPK2(1), MAPKAPK3(2), MAPT(4), MAX(2), MEF2C(4), MKNK1(2), MKNK2(4), MOS(3), MRAS(2), MYC(1), NF1(28), NFATC2(4), NFATC4(8), NFKB1(5), NFKB2(5), NLK(1), NR4A1(3), NRAS(2), NTRK1(8), NTRK2(5), PAK1(4), PAK2(2), PDGFB(2), PDGFRA(6), PDGFRB(7), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PPM1A(2), PPM1B(3), PPP3CA(5), PPP3CB(3), PPP3CC(1), PPP3R1(1), PPP5C(6), PRKACA(4), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(3), PRKX(5), PTPN5(5), PTPN7(5), PTPRR(4), RAF1(4), RAP1A(2), RAP1B(1), RAPGEF2(8), RASA1(2), RASA2(4), RASGRF1(12), RASGRF2(5), RASGRP2(6), RASGRP3(2), RASGRP4(5), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), RPS6KA4(2), RPS6KA5(4), RPS6KA6(6), SOS1(5), SOS2(6), SRF(1), STK3(2), STK4(3), TAOK1(5), TAOK2(8), TAOK3(5), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TGFBR2(4), TNFRSF1A(4), TRAF2(1), TRAF6(4), ZAK(6) 404293685 882 416 870 261 180 209 144 173 173 3 0.461 1.000 1.000 328 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 196 ABI2(3), ACTN1(6), ACTN2(10), ACTN3(7), ACTN4(7), APC(23), ARAF(6), ARHGEF1(10), ARHGEF12(11), ARHGEF4(7), ARHGEF6(6), ARHGEF7(8), ARPC1A(3), ARPC1B(2), ARPC2(5), ARPC5(1), ARPC5L(3), BAIAP2(2), BCAR1(6), BDKRB1(4), BDKRB2(4), BRAF(5), CD14(1), CFL1(1), CFL2(1), CHRM1(4), CHRM2(6), CHRM3(3), CHRM4(1), CRK(1), CRKL(1), CYFIP1(5), CYFIP2(13), DIAPH1(5), DIAPH2(9), DIAPH3(6), DOCK1(8), EGF(5), EGFR(5), EZR(1), F2(2), F2R(4), FGD1(1), FGD3(4), FGF10(2), FGF11(1), FGF12(1), FGF13(4), FGF14(1), FGF16(2), FGF18(4), FGF20(2), FGF21(1), FGF23(3), FGF3(2), FGF6(2), FGF7(3), FGF8(2), FGF9(1), FGFR1(3), FGFR2(12), FGFR3(4), FGFR4(5), FN1(10), GIT1(3), GNA12(2), GNA13(1), GSN(2), HRAS(2), IQGAP1(7), IQGAP2(8), IQGAP3(9), ITGA1(6), ITGA10(10), ITGA11(7), ITGA2(4), ITGA2B(3), ITGA3(1), ITGA4(6), ITGA5(4), ITGA6(4), ITGA7(6), ITGA8(10), ITGA9(7), ITGAD(3), ITGAE(2), ITGAL(5), ITGAM(6), ITGAV(7), ITGAX(10), ITGB1(5), ITGB2(8), ITGB3(4), ITGB4(8), ITGB5(3), ITGB6(6), ITGB7(5), ITGB8(4), LIMK1(8), LIMK2(4), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), MOS(3), MRAS(2), MSN(4), MYH10(14), MYH14(13), MYH9(22), MYL5(3), MYL7(1), MYL9(1), MYLK(11), MYLK2(5), MYLPF(1), NCKAP1(9), NCKAP1L(8), NRAS(2), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PAK7(4), PDGFB(2), PDGFRA(6), PDGFRB(7), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PIP4K2A(2), PIP4K2C(6), PIP5K1A(6), PIP5K1B(2), PIP5K1C(5), PPP1CB(1), PPP1R12A(8), PPP1R12B(4), PTK2(7), RAF1(4), RDX(3), RHOA(6), ROCK1(8), ROCK2(9), SCIN(5), SLC9A1(4), SOS1(5), SOS2(6), SSH1(7), SSH2(5), SSH3(4), TIAM1(7), TIAM2(11), VAV1(6), VAV2(3), VAV3(7), VCL(6), WAS(6), WASF1(6), WASF2(3), WASL(4) 390303008 824 363 810 276 167 209 129 167 149 3 0.987 1.000 1.000 329 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(6), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), ADRA1A(6), ADRA1B(1), ADRB2(2), ADRB3(1), ANXA6(5), ARRB1(1), ARRB2(1), ATP1A4(13), ATP1B1(3), ATP1B3(1), ATP2A2(5), ATP2A3(2), ATP2B1(14), ATP2B2(10), ATP2B3(10), CACNA1A(16), CACNA1B(14), CACNA1C(17), CACNA1D(18), CACNA1E(28), CACNA1S(8), CACNB1(3), CACNB3(4), CALM2(2), CALR(1), CAMK1(1), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CAMK4(5), CASQ1(2), CASQ2(6), CHRM1(4), CHRM2(6), CHRM3(3), CHRM4(1), GJA1(4), GJA4(1), GJA5(4), GJB1(1), GJB2(1), GJB3(3), GJB4(1), GJB5(2), GJB6(1), GNA11(4), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNAZ(3), GNB1(2), GNB2(1), GNB3(3), GNB5(2), GRK4(1), GRK5(2), GRK6(3), ITPR1(15), ITPR2(18), ITPR3(14), KCNB1(7), KCNJ3(2), KCNJ5(1), MIB1(7), NME7(4), PEA15(1), PKIA(1), PKIG(2), PLCB3(2), PLN(1), PRKACA(4), PRKACB(1), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKCA(4), PRKCD(5), PRKCE(8), PRKCG(3), PRKCH(3), PRKCQ(9), PRKCZ(2), PRKD1(6), RGS1(2), RGS10(1), RGS11(2), RGS14(5), RGS16(3), RGS17(3), RGS20(4), RGS3(9), RGS4(4), RGS5(2), RGS6(4), RGS7(10), RGS9(6), RYR1(29), RYR2(53), RYR3(43), SFN(1), SLC8A1(11), SLC8A3(4), USP5(7), YWHAB(2) 274079204 670 344 667 224 160 151 125 141 91 2 0.760 1.000 1.000 330 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 134 ACTB(5), COL11A1(8), COL11A2(5), COL17A1(9), COL1A1(8), COL1A2(10), COL2A1(4), COL3A1(7), COL4A1(9), COL4A2(9), COL4A4(9), COL4A6(10), COL5A1(13), COL5A2(8), COL5A3(11), COL6A1(3), COL6A2(4), COL6A3(15), COL6A6(14), COMP(5), DSC1(3), DSC2(12), DSC3(3), DSG1(4), DSG2(4), DSG3(8), DSG4(6), FN1(10), GJA1(4), GJA10(3), GJA4(1), GJA5(4), GJA8(2), GJA9(1), GJB1(1), GJB2(1), GJB3(3), GJB4(1), GJB5(2), GJB6(1), GJB7(1), GJC1(1), GJD2(2), GJD4(2), IBSP(5), ITGA6(4), ITGB4(8), KRT1(6), KRT10(1), KRT12(1), KRT13(2), KRT14(4), KRT15(1), KRT16(1), KRT17(2), KRT18(3), KRT19(7), KRT2(5), KRT20(2), KRT23(3), KRT24(2), KRT25(5), KRT27(1), KRT28(5), KRT3(4), KRT31(2), KRT32(4), KRT33A(1), KRT33B(1), KRT34(3), KRT35(2), KRT36(2), KRT37(1), KRT38(1), KRT39(1), KRT4(3), KRT40(1), KRT5(4), KRT6A(1), KRT6B(3), KRT6C(1), KRT7(1), KRT71(1), KRT72(3), KRT73(5), KRT74(1), KRT75(4), KRT76(2), KRT78(3), KRT79(2), KRT8(2), KRT81(3), KRT82(4), KRT83(4), KRT84(3), KRT85(3), KRT86(4), KRT9(3), LAMA1(18), LAMA2(15), LAMA3(15), LAMA4(9), LAMA5(11), LAMB1(12), LAMB2(9), LAMB3(7), LAMB4(15), LAMC1(8), LAMC2(6), LAMC3(4), LMNA(4), LMNB1(2), LMNB2(3), NES(14), RELN(26), SPP1(2), THBS1(8), THBS2(2), THBS3(5), THBS4(4), TNC(10), TNN(10), TNR(11), TNXB(16), VIM(2), VTN(3), VWF(11) 346751920 659 344 652 224 133 158 148 118 100 2 0.970 1.000 1.000 331 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 233 ADCYAP1R1(4), ADORA1(3), ADORA2A(4), ADORA3(1), ADRA1A(6), ADRA1B(1), ADRA2B(4), ADRA2C(2), ADRB2(2), ADRB3(1), AGTR1(4), AGTR2(2), AVPR1B(5), AVPR2(3), BDKRB1(4), BDKRB2(4), BRS3(4), C3AR1(3), C5AR1(3), CALCR(2), CALCRL(3), CCKAR(3), CCKBR(2), CHRM1(4), CHRM2(6), CHRM3(3), CHRM4(1), CNR1(1), CNR2(1), CRHR1(3), CRHR2(1), CTSG(1), CYSLTR1(5), CYSLTR2(1), DRD1(1), DRD2(3), DRD3(1), DRD5(4), EDNRA(3), EDNRB(2), F2(2), F2R(4), F2RL1(1), F2RL2(2), FPR1(3), FSHR(9), GABBR1(3), GABBR2(4), GABRA1(4), GABRA2(3), GABRA3(6), GABRA4(7), GABRA5(4), GABRA6(6), GABRB1(3), GABRB2(5), GABRB3(1), GABRD(1), GABRE(2), GABRG1(7), GABRG2(3), GABRG3(4), GABRP(1), GABRQ(5), GABRR1(2), GALR1(1), GALR2(2), GALR3(1), GH2(3), GHR(5), GHRHR(5), GHSR(2), GIPR(1), GLP1R(2), GLP2R(4), GLRA2(2), GLRA3(2), GLRB(1), GPR156(4), GPR35(1), GPR50(4), GPR63(3), GPR83(5), GRIA1(9), GRIA2(4), GRIA3(16), GRIA4(8), GRID1(12), GRID2(11), GRIK1(11), GRIK2(12), GRIK3(6), GRIK4(3), GRIK5(5), GRIN1(3), GRIN2A(16), GRIN2B(11), GRIN2C(5), GRIN2D(5), GRIN3A(10), GRIN3B(3), GRM1(9), GRM2(3), GRM3(10), GRM4(3), GRM5(4), GRM6(2), GRM7(4), GRM8(5), GRPR(3), GZMA(2), HCRTR1(2), HCRTR2(2), HRH1(4), HRH2(4), HRH3(2), HRH4(2), HTR1A(4), HTR1B(3), HTR1D(4), HTR1E(4), HTR1F(4), HTR2A(5), HTR2C(6), HTR5A(4), LEP(1), LEPR(7), LHCGR(10), MAS1(2), MC2R(2), MC3R(3), MC4R(2), MCHR1(1), MCHR2(3), MLNR(1), NMBR(3), NMUR1(3), NMUR2(3), NPBWR1(3), NPFFR2(7), NPY1R(5), NPY2R(3), NR3C1(3), NTSR2(2), OPRD1(3), OPRK1(2), OPRL1(3), OPRM1(5), OXTR(1), P2RX2(3), P2RX3(1), P2RX4(2), P2RX5(4), P2RX7(3), P2RY1(4), P2RY10(7), P2RY13(4), P2RY2(1), P2RY4(2), P2RY6(1), P2RY8(1), PARD3(8), PPYR1(4), PRLHR(2), PRLR(4), PRSS3(3), PTAFR(1), PTGDR(2), PTGER2(2), PTGER3(4), PTGER4(1), PTGFR(1), PTH2R(2), RXFP1(4), RXFP2(3), SSTR2(1), SSTR3(2), SSTR4(1), SSTR5(1), TAAR1(3), TAAR2(4), TAAR5(4), TAAR6(2), TAAR8(1), TAAR9(2), TACR1(2), TACR2(4), TACR3(2), THRA(3), THRB(2), TRPV1(1), TSHR(7), VIPR1(2), VIPR2(4) 305056939 696 335 694 237 152 168 138 159 76 3 0.404 1.000 1.000 332 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 126 ACTB(5), ACTN1(6), ACTN2(10), ACTN3(7), ACTN4(7), AKT1(2), AKT2(5), AKT3(4), AMOTL1(6), ASH1L(19), CASK(9), CDK4(1), CGN(7), CLDN1(1), CLDN10(2), CLDN11(1), CLDN14(1), CLDN15(1), CLDN16(2), CLDN17(2), CLDN18(2), CLDN19(2), CLDN2(1), CLDN22(2), CLDN4(1), CLDN6(6), CRB3(1), CSNK2A1(3), CSNK2A2(1), CTNNA1(7), CTNNA2(14), CTNNA3(6), CTNNB1(2), CTTN(2), EPB41(5), EPB41L1(7), EPB41L2(8), EPB41L3(11), EXOC3(6), EXOC4(9), F11R(4), GNAI1(2), GNAI2(2), GNAI3(1), HCLS1(2), HRAS(2), IGSF5(3), INADL(12), JAM2(1), LLGL1(5), LLGL2(3), MAGI1(17), MAGI2(9), MAGI3(7), MLLT4(20), MPDZ(13), MPP5(3), MRAS(2), MYH1(13), MYH10(14), MYH11(13), MYH13(11), MYH14(13), MYH15(16), MYH2(9), MYH3(5), MYH4(8), MYH6(11), MYH7(20), MYH7B(11), MYH8(15), MYH9(22), MYL5(3), MYL7(1), MYL9(1), MYLPF(1), NRAS(2), OCLN(3), PARD3(8), PARD6A(1), PARD6B(2), PPM1J(2), PPP2CA(3), PPP2CB(2), PPP2R1A(2), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PPP2R3A(4), PPP2R3B(2), PPP2R4(5), PRKCA(4), PRKCD(5), PRKCE(8), PRKCG(3), PRKCH(3), PRKCI(1), PRKCQ(9), PRKCZ(2), RAB13(3), RAB3B(1), RHOA(6), SPTAN1(13), SRC(1), SYMPK(8), TJAP1(3), TJP1(8), TJP2(6), TJP3(4), VAPA(2), YES1(2), ZAK(6) 275428284 628 319 618 182 125 162 98 124 115 4 0.775 1.000 1.000 333 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(7), CD36(5), CD44(4), CD47(2), COL11A1(8), COL11A2(5), COL1A1(8), COL1A2(10), COL2A1(4), COL3A1(7), COL4A1(9), COL4A2(9), COL4A4(9), COL4A6(10), COL5A1(13), COL5A2(8), COL5A3(11), COL6A1(3), COL6A2(4), COL6A3(15), COL6A6(14), DAG1(2), FN1(10), FNDC1(15), FNDC3A(5), GP5(3), GP6(4), HMMR(3), HSPG2(15), IBSP(5), ITGA1(6), ITGA10(10), ITGA11(7), ITGA2(4), ITGA2B(3), ITGA3(1), ITGA4(6), ITGA5(4), ITGA6(4), ITGA7(6), ITGA8(10), ITGA9(7), ITGAV(7), ITGB1(5), ITGB3(4), ITGB4(8), ITGB5(3), ITGB6(6), ITGB7(5), ITGB8(4), LAMA1(18), LAMA2(15), LAMA3(15), LAMA4(9), LAMA5(11), LAMB1(12), LAMB2(9), LAMB3(7), LAMB4(15), LAMC1(8), LAMC2(6), LAMC3(4), RELN(26), SDC1(3), SDC2(2), SDC3(2), SDC4(2), SPP1(2), SV2A(4), SV2B(4), SV2C(1), THBS1(8), THBS2(2), THBS3(5), THBS4(4), TNC(10), TNN(10), TNR(11), TNXB(16), VTN(3), VWF(11) 312799380 592 314 584 199 111 141 126 113 98 3 0.968 1.000 1.000 334 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 136 ACTA1(3), ACTA2(3), ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(6), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), ADM(1), ARRB1(1), ARRB2(1), ATF1(3), ATF2(4), ATF3(2), ATF4(3), ATF5(1), ATP2A2(5), ATP2A3(2), CACNB3(4), CALCA(2), CALM2(2), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CNN1(4), CNN2(1), CORIN(6), CREB3(1), CRHR1(3), DGKZ(1), ETS2(7), FOS(1), GABPA(1), GABPB2(2), GBA2(4), GJA1(4), GNAQ(1), GNB1(2), GNB2(1), GNB3(3), GNB5(2), GRK4(1), GRK5(2), GRK6(3), GSTO1(1), GUCY1A3(2), IGFBP2(1), IGFBP3(1), IGFBP4(1), IGFBP6(1), IL6(2), ITPR1(15), ITPR2(18), ITPR3(14), JUN(3), MIB1(7), MYLK2(5), NFKB1(5), NOS1(13), NOS3(3), OXTR(1), PDE4B(12), PDE4D(8), PKIA(1), PKIG(2), PLCB3(2), PLCD1(3), PLCG1(8), PLCG2(8), PRKACA(4), PRKACB(1), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKCA(4), PRKCD(5), PRKCE(8), PRKCH(3), PRKCQ(9), PRKCZ(2), PRKD1(6), RAMP3(1), RGS1(2), RGS10(1), RGS11(2), RGS14(5), RGS16(3), RGS17(3), RGS20(4), RGS3(9), RGS4(4), RGS5(2), RGS6(4), RGS7(10), RGS9(6), RYR1(29), RYR2(53), RYR3(43), SFN(1), SLC8A1(11), SP1(6), TNXB(16), USP5(7), YWHAB(2) 244696247 576 311 572 192 137 135 101 116 84 3 0.861 1.000 1.000 335 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 125 ABL1(7), ABLIM1(4), ABLIM2(3), ABLIM3(6), ARHGEF12(11), CDK5(2), CFL1(1), CFL2(1), CXCR4(3), DCC(15), DPYSL2(2), DPYSL5(4), EFNA1(2), EFNA3(3), EFNA4(2), EFNA5(1), EFNB1(1), EFNB2(2), EFNB3(3), EPHA1(8), EPHA2(3), EPHA3(6), EPHA4(5), EPHA5(7), EPHA6(7), EPHA7(8), EPHA8(2), EPHB1(12), EPHB2(5), EPHB3(5), EPHB4(4), EPHB6(5), FES(3), GNAI1(2), GNAI2(2), GNAI3(1), GSK3B(2), HRAS(2), ITGB1(5), L1CAM(10), LIMK1(8), LIMK2(4), LRRC4C(4), MAPK1(1), MAPK3(1), MET(10), NCK1(2), NCK2(1), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), NGEF(3), NRAS(2), NRP1(7), NTN1(3), NTN4(1), NTNG1(3), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PAK7(4), PLXNA1(12), PLXNA2(12), PLXNA3(9), PLXNB1(4), PLXNB2(9), PLXNB3(9), PLXNC1(6), PPP3CA(5), PPP3CB(3), PPP3CC(1), PPP3R1(1), PTK2(7), RASA1(2), RGS3(9), RHOA(6), RND1(2), ROBO1(13), ROBO2(11), ROBO3(6), ROCK1(8), ROCK2(9), SEMA3A(5), SEMA3C(7), SEMA3D(4), SEMA3E(2), SEMA3F(2), SEMA3G(2), SEMA4A(4), SEMA4B(2), SEMA4C(2), SEMA4D(8), SEMA4F(9), SEMA4G(6), SEMA5A(12), SEMA5B(6), SEMA6A(12), SEMA6C(5), SEMA6D(5), SEMA7A(2), SLIT1(2), SLIT2(11), SLIT3(5), SRGAP1(10), SRGAP2(12), SRGAP3(4), UNC5A(2), UNC5B(5), UNC5C(3), UNC5D(14) 271243810 590 300 585 179 113 149 122 109 97 0 0.606 1.000 1.000 336 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 249 ACVR1B(8), ACVR2A(8), ACVR2B(1), AMHR2(3), BMP2(3), BMPR1A(1), BMPR1B(6), BMPR2(8), CCL11(1), CCL13(4), CCL14(1), CCL15(1), CCL19(1), CCL2(1), CCL20(1), CCL21(1), CCL23(1), CCL26(1), CCL28(1), CCR1(3), CCR2(7), CCR3(2), CCR4(1), CCR5(1), CCR6(1), CCR7(4), CCR8(1), CCR9(1), CD40(2), CD40LG(1), CD70(1), CLCF1(1), CNTFR(2), CRLF2(1), CSF1(5), CSF1R(3), CSF2RA(3), CSF2RB(4), CSF3(2), CSF3R(6), CX3CL1(2), CX3CR1(3), CXCL10(1), CXCL2(1), CXCL6(3), CXCR3(6), CXCR4(3), CXCR6(1), EDA(2), EDA2R(3), EDAR(4), EGF(5), EGFR(5), EPO(1), EPOR(4), FAS(1), FASLG(2), FLT1(5), FLT3(4), FLT3LG(1), FLT4(3), GDF5(2), GH2(3), GHR(5), HGF(5), IFNA1(1), IFNA10(3), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(3), IFNA2(3), IFNA21(4), IFNA4(2), IFNA6(1), IFNA7(2), IFNA8(2), IFNAR1(2), IFNAR2(1), IFNG(2), IFNGR1(2), IFNK(2), IL10RA(1), IL10RB(3), IL11(1), IL11RA(5), IL12B(2), IL12RB1(7), IL12RB2(4), IL13RA1(1), IL15(3), IL17A(1), IL17B(2), IL17RA(2), IL17RB(3), IL18(2), IL18R1(4), IL18RAP(1), IL19(1), IL1A(1), IL1R1(1), IL1R2(4), IL1RAP(10), IL20(1), IL20RA(1), IL21(2), IL21R(2), IL22(2), IL22RA1(4), IL22RA2(3), IL23A(2), IL23R(4), IL24(3), IL25(2), IL28A(1), IL28B(1), IL28RA(2), IL29(2), IL2RA(2), IL2RB(3), IL2RG(2), IL3(1), IL3RA(3), IL4(1), IL4R(6), IL5RA(4), IL6(2), IL6R(5), IL6ST(9), IL7(1), IL7R(4), IL8(1), IL9R(2), INHBA(4), INHBB(1), INHBC(1), INHBE(3), KDR(8), KIT(8), KITLG(3), LEP(1), LEPR(7), LIF(2), LIFR(9), LTA(2), LTBR(1), MET(10), MPL(2), NGFR(1), OSM(1), OSMR(5), PDGFB(2), PDGFRA(6), PDGFRB(7), PF4(1), PLEKHO2(1), PPBP(1), PRLR(4), RELT(1), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TGFBR2(4), TNFRSF10A(1), TNFRSF10B(1), TNFRSF10D(1), TNFRSF11A(2), TNFRSF11B(3), TNFRSF13B(2), TNFRSF19(2), TNFRSF1A(4), TNFRSF1B(2), TNFRSF21(2), TNFRSF25(2), TNFRSF6B(1), TNFRSF8(4), TNFRSF9(2), TNFSF13(1), TNFSF13B(1), TNFSF14(1), TNFSF15(2), TNFSF18(1), TNFSF4(3), TNFSF8(1), TNFSF9(1), TPO(8), TSLP(1), VEGFA(1), VEGFC(2), XCL1(2), XCR1(3) 251668965 515 283 510 132 77 131 102 108 95 2 0.0777 1.000 1.000 337 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(3), ACTA2(3), ACTN2(10), ACTN3(7), ACTN4(7), DMD(49), FAM48A(4), MYBPC1(4), MYBPC2(11), MYBPC3(3), MYH3(5), MYH6(11), MYH7(20), MYH8(15), MYL1(1), MYL9(1), MYOM1(7), NEB(42), TMOD1(1), TNNC2(2), TNNI3(4), TNNT1(2), TNNT3(3), TPM1(4), TPM2(2), TPM3(3), TPM4(1), TTN(278), VIM(2) 205997026 505 281 502 136 82 169 75 111 63 5 0.597 1.000 1.000 338 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 125 ACACA(13), ACACB(13), AKT1(2), AKT2(5), AKT3(4), ARAF(6), BAD(1), BRAF(5), CALM2(2), CALML6(1), CBL(4), CBLB(14), CBLC(7), CRK(1), CRKL(1), ELK1(4), EXOC7(6), FASN(14), FBP1(2), FLOT1(2), FLOT2(3), FOXO1(2), G6PC(2), G6PC2(3), GCK(3), GSK3B(2), GYS1(8), GYS2(1), HRAS(2), IKBKB(6), INPP5D(4), INSR(11), IRS1(4), IRS4(7), LIPE(5), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK10(4), MAPK3(1), MAPK8(2), MAPK9(1), MKNK1(2), MKNK2(4), NRAS(2), PCK1(5), PCK2(4), PDE3A(12), PDE3B(4), PDPK1(2), PFKL(1), PFKM(8), PFKP(7), PHKA1(8), PHKA2(13), PHKB(4), PHKG2(1), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PKLR(5), PPARGC1A(6), PPP1CB(1), PPP1R3A(13), PPP1R3B(2), PPP1R3C(3), PRKAA1(3), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKACA(4), PRKACB(1), PRKACG(3), PRKAG1(2), PRKAG2(2), PRKAG3(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKCI(1), PRKCZ(2), PRKX(5), PTPRF(11), PYGB(5), PYGL(3), PYGM(5), RAF1(4), RAPGEF1(5), RHEB(1), RHOQ(2), RPS6(4), RPS6KB1(4), RPS6KB2(5), SH2B2(1), SHC1(2), SHC2(3), SHC3(1), SHC4(5), SLC2A4(3), SOCS2(1), SOCS4(2), SORBS1(7), SOS1(5), SOS2(6), SREBF1(4), TRIP10(4), TSC1(5), TSC2(8) 215738806 471 265 467 135 79 132 68 111 81 0 0.451 1.000 1.000 339 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 121 ALCAM(6), CADM1(3), CADM3(2), CD2(4), CD22(5), CD226(2), CD274(2), CD276(1), CD28(2), CD34(3), CD4(4), CD40(2), CD40LG(1), CD58(2), CD6(1), CD86(6), CD8A(3), CD8B(3), CD99(4), CDH15(2), CDH2(2), CDH3(1), CDH4(6), CDH5(1), CLDN1(1), CLDN10(2), CLDN11(1), CLDN14(1), CLDN15(1), CLDN16(2), CLDN17(2), CLDN18(2), CLDN19(2), CLDN2(1), CLDN22(2), CLDN4(1), CLDN6(6), CNTN1(11), CNTN2(7), CNTNAP1(11), CNTNAP2(11), CTLA4(1), ESAM(4), F11R(4), GLG1(6), HLA-A(3), HLA-B(6), HLA-DMA(1), HLA-DMB(3), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(3), HLA-DRB1(10), HLA-F(5), HLA-G(1), ICAM1(2), ICAM2(1), ICAM3(3), ICOS(3), ICOSLG(6), ITGA4(6), ITGA6(4), ITGA8(10), ITGA9(7), ITGAL(5), ITGAM(6), ITGAV(7), ITGB1(5), ITGB2(8), ITGB7(5), ITGB8(4), JAM2(1), L1CAM(10), MADCAM1(1), MAG(3), MPZ(1), MPZL1(3), NCAM1(6), NCAM2(4), NEGR1(2), NEO1(6), NFASC(11), NLGN1(7), NLGN2(7), NLGN3(11), NRCAM(13), NRXN1(12), NRXN2(12), NRXN3(13), OCLN(3), PDCD1(2), PTPRC(8), PTPRF(11), PTPRM(8), PVR(3), PVRL1(3), PVRL2(6), PVRL3(5), SDC1(3), SDC2(2), SDC3(2), SDC4(2), SELE(2), SELL(6), SELP(11), SELPLG(2), SIGLEC1(7), SPN(2), VCAM1(7), VCAN(22) 197586542 504 261 498 150 81 130 98 98 95 2 0.445 1.000 1.000 340 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 149 AKT1(2), AKT2(5), AKT3(4), BCL2L1(1), CBL(4), CBLB(14), CBLC(7), CCND1(1), CCND2(3), CCND3(5), CISH(2), CLCF1(1), CNTFR(2), CREBBP(15), CRLF2(1), CSF2RA(3), CSF2RB(4), CSF3(2), CSF3R(6), EP300(13), EPO(1), EPOR(4), GH2(3), GHR(5), IFNA1(1), IFNA10(3), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(3), IFNA2(3), IFNA21(4), IFNA4(2), IFNA6(1), IFNA7(2), IFNA8(2), IFNAR1(2), IFNAR2(1), IFNG(2), IFNGR1(2), IFNK(2), IL10RA(1), IL10RB(3), IL11(1), IL11RA(5), IL12B(2), IL12RB1(7), IL12RB2(4), IL13RA1(1), IL13RA2(5), IL15(3), IL19(1), IL20(1), IL20RA(1), IL21(2), IL21R(2), IL22(2), IL22RA1(4), IL22RA2(3), IL23A(2), IL23R(4), IL24(3), IL28A(1), IL28B(1), IL28RA(2), IL29(2), IL2RA(2), IL2RB(3), IL2RG(2), IL3(1), IL3RA(3), IL4(1), IL4R(6), IL5RA(4), IL6(2), IL6R(5), IL6ST(9), IL7(1), IL7R(4), IL9R(2), IRF9(4), JAK1(11), JAK2(7), JAK3(8), LEP(1), LEPR(7), LIF(2), LIFR(9), MPL(2), MYC(1), OSM(1), OSMR(5), PIAS1(3), PIAS2(7), PIAS3(3), PIAS4(3), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PRLR(4), PTPN11(1), PTPN6(2), SOCS2(1), SOCS4(2), SOCS5(1), SOCS7(1), SOS1(5), SOS2(6), SPRED1(7), SPRED2(1), SPRY1(7), SPRY2(2), SPRY3(6), STAM(3), STAM2(4), STAT1(4), STAT2(5), STAT3(5), STAT4(8), STAT5A(6), STAT5B(5), STAT6(8), TPO(8), TSLP(1), TYK2(8) 201288342 470 261 466 102 66 114 95 102 90 3 0.0105 1.000 1.000 341 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 140 ADA(2), ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(6), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), ADK(2), ADSL(3), ADSS(3), ADSSL1(1), AK1(1), AK2(1), AK5(4), AK7(4), ALLC(4), AMPD1(9), AMPD2(2), AMPD3(7), ATIC(3), CANT1(2), DCK(1), DGUOK(4), ENPP1(7), ENPP3(6), ENTPD1(4), ENTPD2(3), ENTPD3(1), ENTPD4(4), ENTPD5(7), ENTPD6(4), ENTPD8(1), FHIT(2), GART(3), GDA(2), GMPR2(2), GMPS(5), GUCY1A2(6), GUCY1A3(2), GUCY1B3(2), GUCY2C(9), GUCY2D(4), GUCY2F(7), GUK1(1), IMPDH1(2), IMPDH2(2), ITPA(1), NME6(1), NME7(4), NPR1(5), NPR2(9), NT5C1A(2), NT5C1B(6), NT5C2(3), NT5C3(4), NT5E(6), NUDT2(1), NUDT5(2), NUDT9(2), PAICS(3), PAPSS1(2), PAPSS2(2), PDE10A(8), PDE11A(5), PDE1A(5), PDE1C(5), PDE2A(4), PDE3B(4), PDE4A(1), PDE4B(12), PDE4C(5), PDE4D(8), PDE5A(7), PDE7B(1), PDE8A(1), PDE8B(1), PDE9A(5), PFAS(6), PKLR(5), PNPT1(5), POLA1(15), POLA2(6), POLD1(5), POLD2(1), POLE(10), POLE2(2), POLE3(1), POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2D(1), POLR2F(5), POLR2G(1), POLR2H(1), POLR2J(1), POLR3A(5), POLR3B(2), POLR3GL(3), POLR3H(1), POLR3K(1), PPAT(5), PRIM1(1), PRPS2(1), PRUNE(4), RFC5(1), RRM1(4), RRM2(1), RRM2B(1), XDH(9) 232866942 462 250 457 146 89 129 92 93 58 1 0.816 1.000 1.000 342 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 139 APC(23), AXIN1(5), AXIN2(5), BTRC(4), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CCND1(1), CCND2(3), CCND3(5), CER1(2), CHD8(17), CREBBP(15), CSNK1A1(4), CSNK1A1L(4), CSNK1E(4), CSNK2A1(3), CSNK2A2(1), CTBP1(1), CTBP2(1), CTNNB1(2), CUL1(2), DAAM1(8), DAAM2(5), DKK2(1), DKK4(3), DVL1(2), DVL3(1), EP300(13), FZD1(3), FZD10(4), FZD2(4), FZD3(5), FZD4(1), FZD5(1), FZD6(4), FZD7(3), FZD8(1), FZD9(3), GSK3B(2), JUN(3), LRP5(4), LRP6(7), MAP3K7(3), MAPK10(4), MAPK8(2), MAPK9(1), MYC(1), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), NKD1(1), NKD2(2), NLK(1), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PORCN(4), PPARD(2), PPP2CA(3), PPP2CB(2), PPP2R1A(2), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PPP3CA(5), PPP3CB(3), PPP3CC(1), PPP3R1(1), PRICKLE1(2), PRICKLE2(6), PRKACA(4), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(3), PRKX(5), PSEN1(2), RHOA(6), ROCK1(8), ROCK2(9), RUVBL1(2), SENP2(1), SFRP1(3), SFRP2(2), SFRP4(2), SIAH1(3), SKP1(1), SMAD2(7), SMAD3(4), SMAD4(7), TBL1X(5), TCF7(4), TCF7L1(2), TCF7L2(5), VANGL1(2), VANGL2(8), WIF1(3), WNT10B(1), WNT11(1), WNT16(2), WNT2(1), WNT2B(4), WNT3(1), WNT3A(1), WNT4(1), WNT5B(4), WNT6(1), WNT7A(6), WNT7B(1), WNT8B(2), WNT9A(1) 218110202 448 235 445 142 100 109 67 87 81 4 0.889 1.000 1.000 343 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 105 ACTN1(6), ACTN2(10), ACTN3(7), ACTN4(7), ARHGAP5(12), BCAR1(6), CD99(4), CDH5(1), CLDN1(1), CLDN10(2), CLDN11(1), CLDN14(1), CLDN15(1), CLDN16(2), CLDN17(2), CLDN18(2), CLDN19(2), CLDN2(1), CLDN22(2), CLDN4(1), CLDN6(6), CTNNA1(7), CTNNA2(14), CTNNA3(6), CTNNB1(2), CTNND1(6), CXCR4(3), CYBB(2), ESAM(4), EZR(1), F11R(4), GNAI1(2), GNAI2(2), GNAI3(1), ICAM1(2), ITGA4(6), ITGAL(5), ITGAM(6), ITGB1(5), ITGB2(8), ITK(7), JAM2(1), MAPK13(1), MAPK14(2), MLLT4(20), MMP2(4), MMP9(3), MSN(4), MYL5(3), MYL7(1), MYL9(1), MYLPF(1), NCF1(1), NCF2(7), NCF4(4), NOX1(5), NOX3(2), OCLN(3), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLCG1(8), PLCG2(8), PRKCA(4), PRKCG(3), PTK2(7), PTK2B(7), PTPN11(1), RAP1A(2), RAP1B(1), RAPGEF3(2), RAPGEF4(5), RASSF5(5), RHOA(6), ROCK1(8), ROCK2(9), SIPA1(5), THY1(1), TXK(3), VAV1(6), VAV2(3), VAV3(7), VCAM1(7), VCL(6) 170150535 378 225 375 124 65 87 63 78 84 1 0.922 1.000 1.000 344 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 92 ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(6), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), ATF4(3), CACNA1C(17), CACNA1D(18), CACNA1F(17), CACNA1S(8), CALM2(2), CALML6(1), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), EGFR(5), ELK1(4), GNA11(4), GNAQ(1), GNAS(11), HRAS(2), ITPR1(15), ITPR2(18), ITPR3(14), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K6(1), MAP2K7(1), MAP3K2(3), MAP3K3(1), MAP3K4(8), MAPK1(1), MAPK10(4), MAPK13(1), MAPK14(2), MAPK3(1), MAPK7(4), MAPK8(2), MAPK9(1), MMP14(4), MMP2(4), NRAS(2), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PLD1(7), PLD2(2), PRKACA(4), PRKACB(1), PRKACG(3), PRKCA(4), PRKCD(5), PRKX(5), PTK2B(7), RAF1(4), SOS1(5), SOS2(6), SRC(1) 178705299 379 224 375 124 82 97 57 84 59 0 0.828 1.000 1.000 345 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 90 ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(6), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), DRD1(1), DRD2(3), EGF(5), EGFR(5), GJA1(4), GJD2(2), GNA11(4), GNAI1(2), GNAI2(2), GNAI3(1), GNAQ(1), GNAS(11), GRM1(9), GRM5(4), GUCY1A2(6), GUCY1A3(2), GUCY1B3(2), GUCY2C(9), GUCY2D(4), GUCY2F(7), HRAS(2), HTR2A(5), HTR2C(6), ITPR1(15), ITPR2(18), ITPR3(14), MAP2K1(5), MAP2K2(2), MAP2K5(1), MAP3K2(3), MAPK1(1), MAPK3(1), MAPK7(4), NPR1(5), NPR2(9), NRAS(2), PDGFB(2), PDGFRA(6), PDGFRB(7), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PRKACA(4), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(3), PRKG1(5), PRKG2(8), PRKX(5), RAF1(4), SOS1(5), SOS2(6), SRC(1), TJP1(8), TUBA1A(3), TUBA1B(2), TUBA1C(4), TUBA3C(4), TUBA3D(3), TUBA3E(3), TUBA4A(1), TUBA8(1), TUBAL3(2), TUBB(2), TUBB1(4), TUBB2B(3), TUBB3(2), TUBB6(2), TUBB8(5) 185873702 390 217 386 119 93 101 60 84 52 0 0.492 1.000 1.000 346 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(6), AMY2A(5), AMY2B(1), ASCC3(7), ATP13A2(3), DDX18(3), DDX19A(1), DDX23(4), DDX4(6), DDX41(5), DDX47(1), DDX50(4), DDX51(3), DDX52(2), DDX54(3), DDX55(7), DDX56(2), DHX58(4), ENPP1(7), ENPP3(6), ENTPD7(6), EP400(13), ERCC2(3), ERCC3(5), G6PC(2), G6PC2(3), GAA(2), GANC(4), GBA(2), GBA3(4), GBE1(4), GCK(3), GPI(3), GUSB(6), GYS1(8), GYS2(1), HK1(3), HK2(5), HK3(5), IFIH1(4), LYZL1(1), MGAM(22), MOV10L1(7), NUDT5(2), NUDT8(1), PGM1(5), PGM3(2), PYGB(5), PYGL(3), PYGM(5), RAD54B(9), RAD54L(3), RUVBL2(1), SETX(18), SI(18), SKIV2L2(5), SMARCA2(11), SMARCA5(5), TREH(2), UGDH(1), UGP2(4), UGT1A1(4), UGT1A10(3), UGT1A3(3), UGT1A4(4), UGT1A6(2), UGT1A7(3), UGT1A8(2), UGT1A9(2), UGT2A1(7), UGT2B10(3), UGT2B11(1), UGT2B15(5), UGT2B17(2), UGT2B28(3), UGT2B4(3), UGT2B7(3), UXS1(3) 177904533 349 216 348 105 48 94 56 97 54 0 0.778 1.000 1.000 347 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 73 ARAF(6), BRAF(5), CACNA1A(16), CRHR1(3), GNA11(4), GNA12(2), GNA13(1), GNAI1(2), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNAS(11), GNAZ(3), GRIA1(9), GRIA2(4), GRIA3(16), GRID2(11), GRM1(9), GRM5(4), GUCY1A2(6), GUCY1A3(2), GUCY1B3(2), GUCY2C(9), GUCY2D(4), GUCY2F(7), HRAS(2), IGF1R(7), ITPR1(15), ITPR2(18), ITPR3(14), LYN(6), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), NOS1(13), NOS3(3), NPR1(5), NPR2(9), NRAS(2), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PPP2CA(3), PPP2CB(2), PPP2R1A(2), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PRKCA(4), PRKCG(3), PRKG1(5), PRKG2(8), RAF1(4), RYR1(29) 157273017 367 215 365 95 81 98 68 70 49 1 0.0771 1.000 1.000 348 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 81 ACVR1B(8), ACVRL1(1), AKT1(2), AURKB(3), BMPR1A(1), BMPR2(8), BUB1(3), CDKL1(4), CDKL2(2), CDS1(3), CDS2(3), CLK1(2), CLK2(6), CLK4(3), COL4A3BP(4), CSNK2A1(3), CSNK2A2(1), DGKA(2), DGKB(5), DGKD(10), DGKE(4), DGKG(8), DGKH(4), DGKQ(2), DGKZ(1), IMPA1(3), INPP1(1), INPP4A(5), INPP4B(7), INPP5A(2), INPPL1(6), ITPKA(1), ITPKB(8), MAP3K10(3), MOS(3), NEK1(6), NEK3(3), OCRL(8), PAK4(3), PIK3C2A(5), PIK3C2B(12), PIK3C2G(8), PIK3CB(8), PIK3CG(5), PIM2(4), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PLCD1(3), PLCG1(8), PLCG2(8), PLK3(1), PRKACA(4), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKCA(4), PRKCD(5), PRKCE(8), PRKCG(3), PRKCH(3), PRKCQ(9), PRKCZ(2), PRKD1(6), PRKG1(5), RAF1(4), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), RPS6KA4(2), RPS6KB1(4), STK11(2), TGFBR1(4), VRK1(2) 159309417 354 215 350 84 63 81 49 72 86 3 0.158 1.000 1.000 349 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(19), ASH2L(4), CARM1(5), CTCFL(5), DOT1L(10), EED(4), EHMT1(9), EHMT2(6), EZH1(3), EZH2(3), FBXO11(5), HCFC1(19), HSF4(1), JMJD6(2), KDM6A(17), MEN1(4), MLL(20), MLL2(25), MLL4(14), MLL5(11), NSD1(13), OGT(5), PAXIP1(6), PPP1CB(1), PRDM2(8), PRDM6(1), PRDM7(2), PRDM9(6), PRMT5(6), PRMT6(2), PRMT7(3), PRMT8(4), RBBP5(3), SATB1(10), SETD1A(4), SETD1B(9), SETD2(19), SETD7(5), SETD8(4), SETDB1(11), SETDB2(2), SETMAR(2), SMYD3(5), STK38(4), SUV39H1(2), SUV39H2(1), SUV420H1(8), SUV420H2(2), SUZ12(7), WHSC1(7), WHSC1L1(5) 159895189 353 212 347 74 48 91 59 66 88 1 0.160 1.000 1.000 350 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 70 CALM2(2), CALML6(1), CDS1(3), CDS2(3), DGKA(2), DGKB(5), DGKD(10), DGKE(4), DGKG(8), DGKH(4), DGKI(7), DGKQ(2), DGKZ(1), FN3K(3), IMPA1(3), IMPA2(4), INPP1(1), INPP4A(5), INPP4B(7), INPP5A(2), INPP5B(7), INPP5D(4), INPP5E(1), INPPL1(6), ITPK1(1), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), OCRL(8), PI4KA(10), PI4KB(6), PIK3C2A(5), PIK3C2B(12), PIK3C2G(8), PIK3C3(6), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PIP4K2A(2), PIP4K2C(6), PIP5K1A(6), PIP5K1B(2), PIP5K1C(5), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PLCD1(3), PLCD3(2), PLCD4(6), PLCE1(15), PLCG1(8), PLCG2(8), PLCZ1(11), PRKCA(4), PRKCG(3), SYNJ1(4), SYNJ2(4) 172470870 365 211 361 100 64 90 52 81 77 1 0.421 1.000 1.000 351 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 72 ACTB(5), ACTN1(6), ACTN2(10), ACTN3(7), ACTN4(7), ACVR1B(8), ACVR1C(2), BAIAP2(2), CREBBP(15), CSNK2A1(3), CSNK2A2(1), CTNNA1(7), CTNNA2(14), CTNNA3(6), CTNNB1(2), CTNND1(6), EGFR(5), EP300(13), FARP2(10), FER(5), FGFR1(3), IGF1R(7), INSR(11), IQGAP1(7), LMO7(6), MAP3K7(3), MAPK1(1), MAPK3(1), MET(10), MLLT4(20), NLK(1), PARD3(8), PTPN6(2), PTPRB(12), PTPRF(11), PTPRJ(7), PTPRM(8), PVRL1(3), PVRL2(6), PVRL3(5), PVRL4(2), RHOA(6), SMAD2(7), SMAD3(4), SMAD4(7), SNAI1(2), SORBS1(7), SRC(1), SSX2IP(4), TCF7(4), TCF7L1(2), TCF7L2(5), TGFBR1(4), TGFBR2(4), TJP1(8), VCL(6), WAS(6), WASF1(6), WASF2(3), WASF3(5), WASL(4), YES1(2) 165568431 365 210 359 105 70 103 53 63 76 0 0.653 1.000 1.000 352 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(11), ABCA10(15), ABCA12(12), ABCA13(37), ABCA2(7), ABCA3(10), ABCA4(12), ABCA5(8), ABCA6(9), ABCA7(10), ABCA8(16), ABCA9(13), ABCB1(9), ABCB10(9), ABCB11(13), ABCB4(10), ABCB5(5), ABCB6(8), ABCB7(7), ABCB8(8), ABCB9(1), ABCC1(12), ABCC10(7), ABCC11(7), ABCC12(10), ABCC2(7), ABCC3(9), ABCC4(10), ABCC5(10), ABCC6(7), ABCC8(12), ABCC9(13), ABCD1(5), ABCD2(4), ABCD3(4), ABCD4(3), ABCG1(5), ABCG2(1), ABCG4(7), ABCG5(2), ABCG8(2), CFTR(14), TAP1(2) 167928951 383 209 381 100 53 112 72 86 58 2 0.0460 1.000 1.000 353 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(2), ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(6), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADK(2), ADSL(3), ADSS(3), AK1(1), AK2(1), AK5(4), ALLC(4), AMPD1(9), AMPD2(2), AMPD3(7), ATIC(3), ATP1B1(3), ATP5A1(4), ATP5B(1), ATP5C1(1), ATP5F1(3), ATP5G2(2), CANT1(2), DCK(1), DGUOK(4), ENPP1(7), ENPP3(6), ENTPD1(4), ENTPD2(3), FHIT(2), GART(3), GDA(2), GMPS(5), GUCY1A2(6), GUCY1A3(2), GUCY1B3(2), GUCY2C(9), GUCY2D(4), GUCY2F(7), GUK1(1), IMPDH1(2), IMPDH2(2), ITPA(1), NPR1(5), NPR2(9), NT5E(6), NUDT2(1), PAICS(3), PAPSS1(2), PAPSS2(2), PDE1A(5), PDE4A(1), PDE4B(12), PDE4C(5), PDE4D(8), PDE5A(7), PDE6B(3), PDE6C(6), PDE7B(1), PDE8A(1), PDE9A(5), PFAS(6), PKLR(5), POLB(1), POLD1(5), POLD2(1), POLE(10), POLG(7), POLL(3), POLQ(12), POLR1B(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2D(1), POLR2F(5), POLR2G(1), POLR2H(1), POLR2J(1), POLRMT(5), PPAT(5), PRPS2(1), PRUNE(4), RRM1(4), RRM2(1) 181269997 355 209 350 116 69 101 65 70 49 1 0.872 1.000 1.000 354 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 104 ABL1(7), ANAPC1(11), ANAPC10(1), ANAPC11(1), ANAPC4(4), ANAPC5(5), ANAPC7(5), ATM(23), ATR(13), BUB1(3), BUB1B(5), BUB3(3), CCNA2(4), CCNB1(3), CCNB3(14), CCND1(1), CCND2(3), CCND3(5), CCNE1(2), CCNE2(4), CCNH(2), CDC14A(3), CDC14B(1), CDC16(3), CDC20(1), CDC23(2), CDC25A(1), CDC25B(3), CDC25C(6), CDC6(4), CDC7(2), CDK2(2), CDK4(1), CDK6(2), CDK7(3), CDKN1A(1), CDKN2A(1), CHEK1(2), CHEK2(6), CREBBP(15), CUL1(2), E2F1(5), E2F3(3), EP300(13), ESPL1(13), GSK3B(2), HDAC1(5), HDAC2(2), MAD1L1(4), MAD2L1(4), MAD2L2(3), MCM2(5), MCM3(4), MCM4(5), MCM5(3), MCM6(4), MCM7(7), MDM2(3), PKMYT1(1), PLK1(2), PRKDC(24), PTTG1(1), PTTG2(1), RBL1(6), SFN(1), SKP1(1), SKP2(2), SMAD2(7), SMAD3(4), SMAD4(7), SMC1A(10), SMC1B(6), TFDP1(3), TGFB1(2), TGFB2(1), TGFB3(1), WEE1(4), YWHAB(2), YWHAG(1), YWHAZ(3) 189370820 355 205 351 78 49 105 51 70 79 1 0.173 1.000 1.000 355 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 91 ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(6), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), AKAP1(3), AKAP10(1), AKAP11(13), AKAP12(10), AKAP3(6), AKAP4(8), AKAP6(16), AKAP7(1), AKAP8(4), AKAP9(24), ARHGEF1(10), CALM2(2), GNA11(4), GNA12(2), GNA13(1), GNA14(1), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNAZ(3), GNB1(2), GNB2(1), GNB3(3), GNB5(2), HRAS(2), IL18BP(2), ITPR1(15), KCNJ3(2), NRAS(2), PALM2(3), PDE1A(5), PDE1B(5), PDE1C(5), PDE4A(1), PDE4B(12), PDE4C(5), PDE4D(8), PDE7B(1), PDE8A(1), PDE8B(1), PLCB3(2), PPP3CA(5), PPP3CC(1), PRKACA(4), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKCA(4), PRKCD(5), PRKCE(8), PRKCG(3), PRKCH(3), PRKCI(1), PRKCQ(9), PRKCZ(2), PRKD1(6), PRKD3(6), RHOA(6), SLC9A1(4), USP5(7) 166583869 346 204 344 102 69 92 58 71 54 2 0.617 1.000 1.000 356 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 149 ADORA1(3), ADORA2A(4), ADORA3(1), ADRA1A(6), ADRA1B(1), ADRA2C(2), ADRB2(2), ADRB3(1), AGTR1(4), AGTR2(2), AVPR1B(5), AVPR2(3), BDKRB1(4), BDKRB2(4), BRS3(4), C3AR1(3), CCBP2(3), CCKAR(3), CCKBR(2), CCR1(3), CCR2(7), CCR3(2), CCR4(1), CCR5(1), CCR6(1), CCR7(4), CCR8(1), CCR9(1), CCRL1(1), CCRL2(4), CHML(4), CHRM1(4), CHRM2(6), CHRM3(3), CHRM4(1), CMKLR1(4), CNR1(1), CNR2(1), CX3CR1(3), CXCR3(6), CXCR4(3), DRD1(1), DRD2(3), DRD3(1), DRD5(4), EDNRA(3), EDNRB(2), F2R(4), F2RL1(1), F2RL2(2), FPR1(3), FSHR(9), GALR1(1), GALR2(2), GALR3(1), GALT(2), GHSR(2), GNB2L1(5), GPR17(2), GPR173(1), GPR174(4), GPR3(2), GPR35(1), GPR37(5), GPR37L1(1), GPR50(4), GPR6(2), GPR63(3), GPR77(2), GPR83(5), GPR85(2), GPR87(2), GRPR(3), HCRTR1(2), HCRTR2(2), HRH1(4), HRH2(4), HRH3(2), HTR1A(4), HTR1B(3), HTR1D(4), HTR1E(4), HTR1F(4), HTR2A(5), HTR2C(6), HTR5A(4), LHCGR(10), MAS1(2), MC3R(3), MC4R(2), MLNR(1), NMBR(3), NMUR1(3), NMUR2(3), NPY1R(5), NPY2R(3), NTSR2(2), OPN1SW(3), OPN3(1), OPRD1(3), OPRK1(2), OPRL1(3), OPRM1(5), OXTR(1), P2RY1(4), P2RY10(7), P2RY13(4), P2RY2(1), P2RY6(1), PPYR1(4), PTAFR(1), PTGDR(2), PTGER2(2), PTGER4(1), PTGFR(1), RGR(1), RHO(2), RRH(1), SSTR2(1), SSTR3(2), SSTR4(1) 154900991 343 204 343 123 78 72 61 93 38 1 0.388 1.000 1.000 357 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(2), AKT3(4), BCAR1(6), CAPN1(8), CAPN10(5), CAPN11(3), CAPN2(8), CAPN3(3), CAPN6(3), CAPN7(2), CAPN9(1), CAV1(4), CRK(1), DOCK1(8), GIT2(1), ILK(3), ITGA10(10), ITGA11(7), ITGA2(4), ITGA2B(3), ITGA3(1), ITGA4(6), ITGA5(4), ITGA6(4), ITGA7(6), ITGA8(10), ITGA9(7), ITGAD(3), ITGAE(2), ITGAL(5), ITGAM(6), ITGAV(7), ITGAX(10), ITGB1(5), ITGB2(8), ITGB3(4), ITGB4(8), ITGB5(3), ITGB6(6), ITGB7(5), ITGB8(4), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K6(1), MAPK10(4), MAPK4(6), MAPK6(6), MAPK7(4), MYLK2(5), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PDPK1(2), PIK3R2(4), PTK2(7), RAP1B(1), RAPGEF1(5), RHO(2), ROCK1(8), ROCK2(9), SDCCAG8(6), SEPP1(3), SHC1(2), SHC3(1), SORBS1(7), SOS1(5), SRC(1), TLN1(16), TNS1(7), VAV2(3), VAV3(7), VCL(6), ZYX(2) 192453535 359 201 358 118 66 100 57 74 60 2 0.880 1.000 1.000 358 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 98 ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(6), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), CALM2(2), CALML6(1), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CREB1(2), CREB3(1), CREB3L1(3), CREB3L2(4), CREB3L3(8), CREB3L4(2), CREBBP(15), CTNNB1(2), DCT(4), DVL1(2), DVL3(1), EDN1(5), EDNRB(2), EP300(13), FZD1(3), FZD10(4), FZD2(4), FZD3(5), FZD4(1), FZD5(1), FZD6(4), FZD7(3), FZD8(1), FZD9(3), GNAI1(2), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNAS(11), GSK3B(2), HRAS(2), KIT(8), KITLG(3), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), MITF(3), NRAS(2), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PRKACA(4), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(3), PRKX(5), RAF1(4), TCF7(4), TCF7L1(2), TCF7L2(5), TYR(5), TYRP1(7), WNT10B(1), WNT11(1), WNT16(2), WNT2(1), WNT2B(4), WNT3(1), WNT3A(1), WNT4(1), WNT5B(4), WNT6(1), WNT7A(6), WNT7B(1), WNT8B(2), WNT9A(1) 147770145 331 199 328 107 81 72 58 66 54 0 0.797 1.000 1.000 359 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 66 A2M(8), BDKRB1(4), BDKRB2(4), C1QA(1), C1QB(1), C1R(6), C1S(1), C2(1), C3(8), C3AR1(3), C4BPA(4), C4BPB(1), C5(5), C5AR1(3), C6(8), C7(8), C8A(2), C8B(3), C8G(1), C9(5), CD46(2), CD55(3), CD59(2), CFB(4), CFH(13), CFI(1), CPB2(4), CR1(14), CR2(5), F10(5), F12(2), F13A1(5), F13B(5), F2(2), F2R(4), F5(26), F7(2), F8(20), F9(1), FGA(7), FGB(1), FGG(7), KLKB1(5), KNG1(4), MASP1(8), MASP2(2), MBL2(2), PLAT(6), PLAU(4), PLAUR(2), PLG(7), PROC(3), PROS1(4), SERPINA1(4), SERPINA5(5), SERPINC1(6), SERPIND1(1), SERPINE1(5), SERPINF2(2), SERPING1(3), TFPI(4), THBD(2), VWF(11) 128318001 302 194 300 80 47 72 72 63 47 1 0.339 1.000 1.000 360 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 122 ARAF(6), BID(4), BRAF(5), CASP3(1), CD244(3), CD48(2), FAS(1), FASLG(2), FCGR3A(4), FCGR3B(2), HLA-A(3), HLA-B(6), HLA-G(1), HRAS(2), ICAM1(2), ICAM2(1), IFNA1(1), IFNA10(3), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(3), IFNA2(3), IFNA21(4), IFNA4(2), IFNA6(1), IFNA7(2), IFNA8(2), IFNAR1(2), IFNAR2(1), IFNG(2), IFNGR1(2), ITGAL(5), ITGB2(8), KIR2DL1(3), KIR2DL3(3), KIR2DL4(4), KIR3DL1(3), KIR3DL2(6), KLRC1(5), KLRC3(1), KLRD1(1), KLRK1(2), LAT(1), LCK(2), LCP2(2), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), MICA(3), MICB(2), NCR1(3), NCR2(3), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), NRAS(2), PAK1(4), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLCG1(8), PLCG2(8), PPP3CA(5), PPP3CB(3), PPP3CC(1), PPP3R1(1), PRF1(2), PRKCA(4), PRKCG(3), PTK2B(7), PTPN11(1), PTPN6(2), RAF1(4), SHC1(2), SHC2(3), SHC3(1), SHC4(5), SOS1(5), SOS2(6), SYK(4), TNFRSF10A(1), TNFRSF10B(1), TNFRSF10D(1), ULBP1(2), ULBP2(3), ULBP3(3), VAV1(6), VAV2(3), VAV3(7), ZAP70(3) 150721605 322 194 320 98 45 97 61 65 53 1 0.623 1.000 1.000 361 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 90 AKT1(2), AKT2(5), AKT3(4), BCL10(3), CARD11(7), CBL(4), CBLB(14), CBLC(7), CD28(2), CD3E(3), CD3G(3), CD4(4), CD40LG(1), CD8A(3), CD8B(3), CDK4(1), CHUK(8), CTLA4(1), FOS(1), GRAP2(2), HRAS(2), ICOS(3), IFNG(2), IKBKB(6), IL4(1), ITK(7), JUN(3), LAT(1), LCK(2), LCP2(2), MALT1(3), MAP3K8(4), NCK1(2), NCK2(1), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), NRAS(2), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PAK7(4), PDCD1(2), PDK1(2), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(1), PPP3R1(1), PRKCQ(9), PTPN6(2), PTPRC(8), RHOA(6), SOS1(5), SOS2(6), TEC(6), VAV1(6), VAV2(3), VAV3(7), ZAP70(3) 135559296 306 192 305 87 47 84 51 60 63 1 0.658 1.000 1.000 362 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 66 ADCY1(5), ADCY8(6), ARAF(6), ATF4(3), BRAF(5), CACNA1C(17), CALM2(2), CALML6(1), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CAMK4(5), CREBBP(15), EP300(13), GNAQ(1), GRIA1(9), GRIA2(4), GRIN1(3), GRIN2A(16), GRIN2B(11), GRIN2C(5), GRIN2D(5), GRM1(9), GRM5(4), HRAS(2), ITPR1(15), ITPR2(18), ITPR3(14), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), NRAS(2), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PPP1CB(1), PPP1R12A(8), PPP1R1A(5), PPP3CA(5), PPP3CB(3), PPP3CC(1), PPP3R1(1), PRKACA(4), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(3), PRKX(5), RAF1(4), RAP1A(2), RAP1B(1), RAPGEF3(2), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), RPS6KA6(6) 144558938 335 191 332 101 71 87 53 70 54 0 0.481 1.000 1.000 363 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 107 ALG1(2), ALG10(3), ALG10B(6), ALG11(1), ALG12(3), ALG13(5), ALG14(1), ALG2(2), ALG3(1), ALG6(2), ALG8(2), ALG9(2), B3GNT1(1), B3GNT2(2), B3GNT7(2), B4GALT1(3), B4GALT3(2), B4GALT4(2), B4GALT5(4), B4GALT7(1), C1GALT1(3), C1GALT1C1(3), CHPF(2), CHST1(4), CHST11(1), CHST2(5), CHST3(1), CHST4(1), CHST7(1), CHSY1(3), DAD1(1), DDOST(2), DPAGT1(4), EXT1(7), EXT2(6), EXTL1(1), EXTL2(1), EXTL3(6), FUT11(3), FUT8(2), GALNT1(3), GALNT10(5), GALNT11(5), GALNT12(2), GALNT13(6), GALNT14(1), GALNT2(2), GALNT3(3), GALNT4(1), GALNT5(6), GALNT6(3), GALNT7(5), GALNT8(6), GALNT9(6), GALNTL1(3), GALNTL2(2), GALNTL4(1), GALNTL5(7), GANAB(10), GCNT3(1), GCNT4(3), HS2ST1(3), HS3ST1(2), HS3ST2(4), HS3ST3A1(1), HS3ST3B1(1), HS3ST5(5), HS6ST1(5), HS6ST2(7), HS6ST3(3), MAN1A1(6), MAN1A2(3), MAN1B1(3), MAN2A1(6), MGAT3(4), MGAT4A(4), MGAT4B(5), MGAT5(3), MGAT5B(8), NDST1(4), NDST2(1), NDST3(5), OGT(5), RPN1(4), RPN2(2), ST3GAL1(2), ST3GAL2(2), ST3GAL3(5), ST3GAL4(2), ST6GAL1(3), ST6GALNAC1(6), STT3B(3), UST(2), WBSCR17(7), XYLT1(4), XYLT2(5) 151670375 320 190 318 100 63 77 54 74 48 4 0.740 1.000 1.000 364 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 79 ABL1(7), ABL2(6), AKT1(2), AKT2(5), AKT3(4), ARAF(6), AREG(1), BAD(1), BRAF(5), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CBL(4), CBLB(14), CBLC(7), CDKN1A(1), CRK(1), CRKL(1), EGF(5), EGFR(5), ELK1(4), ERBB3(19), ERBB4(14), GAB1(2), GSK3B(2), HRAS(2), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K7(1), MAPK1(1), MAPK10(4), MAPK3(1), MAPK8(2), MAPK9(1), MYC(1), NCK1(2), NCK2(1), NRAS(2), NRG1(4), NRG2(4), NRG3(7), NRG4(1), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PAK7(4), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLCG1(8), PLCG2(8), PRKCA(4), PRKCG(3), PTK2(7), RAF1(4), RPS6KB1(4), RPS6KB2(5), SHC1(2), SHC2(3), SHC3(1), SHC4(5), SOS1(5), SOS2(6), SRC(1), STAT5A(6), STAT5B(5), TGFA(1) 132827145 305 190 303 84 53 78 47 71 56 0 0.442 1.000 1.000 365 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 75 ABL1(7), ACTN1(6), ACTR2(2), ACTR3(2), AKT1(2), AKT2(5), AKT3(4), ANGPTL2(1), ARHGEF6(6), ARHGEF7(8), BCAR1(6), BRAF(5), CAV1(4), CDKN2A(1), CRK(1), CSE1L(6), DOCK1(8), EPHB2(5), GRB7(4), ILK(3), ITGA1(6), ITGA10(10), ITGA11(7), ITGA2(4), ITGA3(1), ITGA4(6), ITGA5(4), ITGA6(4), ITGA7(6), ITGA8(10), ITGA9(7), ITGB3BP(3), MAP2K7(1), MAP3K11(5), MAPK1(1), MAPK10(4), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(8), MAPK9(1), MRAS(2), MYLK(11), MYLK2(5), P4HB(2), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PAK7(4), PIK3CB(8), PKLR(5), PLCG1(8), PLCG2(8), PTK2(7), RAF1(4), RALA(1), RHO(2), ROCK1(8), ROCK2(9), SHC1(2), SOS1(5), SOS2(6), SRC(1), TERF2IP(3), TLN1(16), TLN2(14), WAS(6), ZYX(2) 168229836 337 190 337 90 65 86 46 80 58 2 0.231 1.000 1.000 366 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 79 ABL1(7), ATM(23), BUB1(3), BUB1B(5), BUB3(3), CCNA2(4), CCNB1(3), CCNB3(14), CCND2(3), CCND3(5), CCNE1(2), CCNE2(4), CCNH(2), CDAN1(2), CDC14A(3), CDC14B(1), CDC20(1), CDC25A(1), CDC25B(3), CDC25C(6), CDC6(4), CDC7(2), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(1), CHEK1(2), CHEK2(6), DTX4(2), E2F1(5), E2F3(3), E2F4(2), E2F6(2), EP300(13), ESPL1(13), GSK3B(2), HDAC1(5), HDAC2(2), HDAC3(1), HDAC4(6), HDAC5(6), HDAC6(16), HDAC8(3), MAD1L1(4), MAD2L1(4), MAD2L2(3), MCM2(5), MCM3(4), MCM4(5), MCM5(3), MCM6(4), MCM7(7), MDM2(3), MPEG1(4), MPL(2), PLK1(2), PRKDC(24), PTPRA(6), PTTG1(1), PTTG2(1), RBL1(6), SKP2(2), SMAD4(7), TBC1D8(7), TFDP1(3), TGFB1(2), WEE1(4) 153913343 308 186 305 74 39 89 50 57 72 1 0.342 1.000 1.000 367 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 85 ACVR1B(8), ACVR1C(2), ACVR2A(8), ACVR2B(1), ACVRL1(1), AMHR2(3), BMP2(3), BMP4(2), BMP5(4), BMP6(2), BMP8B(2), BMPR1A(1), BMPR1B(6), BMPR2(8), CHRD(5), COMP(5), CREBBP(15), CUL1(2), DCN(2), E2F4(2), EP300(13), FST(3), GDF5(2), GDF6(1), ID1(1), ID2(2), ID3(1), IFNG(2), INHBA(4), INHBB(1), INHBC(1), INHBE(3), LEFTY2(1), LTBP1(9), MAPK1(1), MAPK3(1), MYC(1), NODAL(1), NOG(1), PITX2(5), PPP2CA(3), PPP2CB(2), PPP2R1A(2), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), RBL1(6), RHOA(6), ROCK1(8), ROCK2(9), RPS6KB1(4), RPS6KB2(5), SKP1(1), SMAD1(1), SMAD2(7), SMAD3(4), SMAD4(7), SMAD5(2), SMAD7(1), SMAD9(4), SMURF1(3), SMURF2(5), SP1(6), TFDP1(3), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TGFBR2(4), THBS1(8), THBS2(2), THBS3(5), THBS4(4), ZFYVE16(5), ZFYVE9(4) 137911792 270 177 265 70 52 65 28 66 59 0 0.463 1.000 1.000 368 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 81 ATF2(4), BRAF(5), CHUK(8), CREB1(2), DAXX(2), ELK1(4), FOS(1), HRAS(2), IKBKB(6), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K5(1), MAP2K6(1), MAP2K7(1), MAP3K10(3), MAP3K11(5), MAP3K12(7), MAP3K13(10), MAP3K2(3), MAP3K3(1), MAP3K4(8), MAP3K5(12), MAP3K6(3), MAP3K7(3), MAP3K8(4), MAP3K9(6), MAP4K1(10), MAP4K2(2), MAP4K3(2), MAP4K4(13), MAP4K5(1), MAPK1(1), MAPK10(4), MAPK13(1), MAPK14(2), MAPK3(1), MAPK4(6), MAPK6(6), MAPK7(4), MAPK8(2), MAPK9(1), MAPKAPK2(1), MAPKAPK3(2), MAX(2), MEF2A(6), MEF2C(4), MEF2D(3), MKNK1(2), MKNK2(4), MYC(1), NFKB1(5), NFKBIA(3), PAK1(4), PAK2(2), RAF1(4), RELA(3), RIPK1(5), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), RPS6KA4(2), RPS6KA5(4), RPS6KB1(4), RPS6KB2(5), SHC1(2), SP1(6), STAT1(4), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TRAF2(1) 131576012 278 175 274 54 54 79 32 50 63 0 0.00642 1.000 1.000 369 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 89 ACTB(5), BAD(1), CABIN1(8), CALM2(2), CAMK2B(3), CAMK4(5), CD3E(3), CD3G(3), CD69(2), CDKN1A(1), CNR1(1), CREBBP(15), CSNK2A1(3), CTLA4(1), EGR2(3), EGR3(4), EP300(13), FCER1A(4), FCGR3A(4), FOS(1), GATA4(2), GSK3A(5), GSK3B(2), HRAS(2), ICOS(3), IFNA1(1), IFNG(2), IL2RA(2), IL3(1), IL4(1), IL6(2), IL8(1), ITK(7), KPNA5(5), MAP2K7(1), MAPK14(2), MAPK8(2), MAPK9(1), MEF2A(6), MEF2D(3), MYF5(4), NCK2(1), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), NFKB2(5), NFKBIB(2), NFKBIE(2), NUP214(12), OPRD1(3), P2RX7(3), PAK1(4), PPP3CB(3), PPP3CC(1), PPP3R1(1), PTPRC(8), RELA(3), RPL13A(4), SFN(1), SLA(1), SP1(6), SP3(7), TGFB1(2), TRAF2(1), TRPV6(5), VAV1(6), VAV2(3), VAV3(7), XPO5(8) 126119295 269 168 268 66 33 66 46 61 63 0 0.229 1.000 1.000 370 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 81 ANPEP(8), CD14(1), CD19(6), CD1A(2), CD1B(5), CD1C(4), CD1D(3), CD1E(7), CD2(4), CD22(5), CD33(2), CD34(3), CD36(5), CD37(3), CD38(3), CD3E(3), CD3G(3), CD4(4), CD44(4), CD5(3), CD55(3), CD59(2), CD7(1), CD8A(3), CD8B(3), CD9(2), CR1(14), CR2(5), CSF1(5), CSF1R(3), CSF2RA(3), CSF3(2), CSF3R(6), DNTT(6), EPO(1), EPOR(4), FCER2(1), FCGR1A(5), FLT3(4), FLT3LG(1), GP5(3), GYPA(1), HLA-DRB1(10), IL11(1), IL11RA(5), IL1A(1), IL1R1(1), IL1R2(4), IL2RA(2), IL3(1), IL3RA(3), IL4(1), IL4R(6), IL5RA(4), IL6(2), IL6R(5), IL7(1), IL7R(4), IL9R(2), ITGA1(6), ITGA2(4), ITGA2B(3), ITGA3(1), ITGA4(6), ITGA5(4), ITGA6(4), ITGAM(6), ITGB3(4), KIT(8), KITLG(3), MME(1), MS4A1(1), TFRC(2), THPO(3), TPO(8) 116462184 273 168 273 78 40 68 56 62 46 1 0.511 1.000 1.000 371 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 95 AKT1(2), AKT2(5), AKT3(4), CD14(1), CD40(2), CD86(6), CHUK(8), CXCL10(1), FOS(1), IFNA1(1), IFNA10(3), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(3), IFNA2(3), IFNA21(4), IFNA4(2), IFNA6(1), IFNA7(2), IFNA8(2), IFNAR1(2), IFNAR2(1), IKBKB(6), IKBKE(6), IL12B(2), IL6(2), IL8(1), IRAK1(5), IRAK4(3), IRF3(6), IRF5(2), IRF7(1), JUN(3), LBP(1), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K6(1), MAP2K7(1), MAP3K7(3), MAP3K8(4), MAPK1(1), MAPK10(4), MAPK13(1), MAPK14(2), MAPK3(1), MAPK8(2), MAPK9(1), MYD88(1), NFKB1(5), NFKB2(5), NFKBIA(3), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), RELA(3), RIPK1(5), SPP1(2), STAT1(4), TBK1(1), TICAM1(2), TIRAP(1), TLR1(3), TLR2(3), TLR3(7), TLR4(15), TLR5(4), TLR7(9), TLR8(13), TLR9(2), TRAF3(3), TRAF6(4) 116791160 257 163 257 57 32 73 42 56 52 2 0.0473 1.000 1.000 372 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 90 CD2BP2(1), CDC40(3), CLK2(6), CLK3(4), CLK4(3), COL2A1(4), CPSF1(10), CPSF2(3), CPSF3(6), CPSF4(4), CSTF1(1), CSTF2(2), CSTF2T(4), CSTF3(8), DDX1(3), DDX20(4), DHX15(9), DHX16(2), DHX38(4), DHX8(7), DHX9(8), DICER1(8), DNAJC8(1), FUS(3), GIPC1(1), METTL3(2), NCBP1(1), NCBP2(1), NONO(2), NUDT21(1), NXF1(8), PABPN1(1), PAPOLA(5), POLR2A(6), PPM1G(2), PRPF18(2), PRPF3(5), PRPF4(3), PRPF4B(9), PRPF8(12), PSKH1(3), PTBP1(6), PTBP2(3), RBM17(1), RBM5(5), RNGTT(2), RNMT(1), RNPS1(2), SF3A1(2), SF3A2(1), SF3A3(1), SF3B1(16), SF3B2(5), SF3B4(3), SF3B5(1), SNRPA(1), SNRPB(2), SNRPD2(2), SNRPG(2), SNRPN(3), SPOP(5), SRPK1(3), SRPK2(5), SRRM1(6), SUPT5H(12), TXNL4A(1), U2AF1(1), U2AF2(1), XRN2(4) 149670972 269 163 262 59 31 73 47 71 45 2 0.193 1.000 1.000 373 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 77 AIFM1(3), AKT1(2), AKT2(5), AKT3(4), APAF1(11), ATM(23), BAD(1), BAX(3), BCL2L1(1), BID(4), BIRC2(3), BIRC3(4), CAPN1(8), CAPN2(8), CASP10(2), CASP3(1), CASP6(2), CASP7(2), CASP9(3), CFLAR(1), CHUK(8), CSF2RB(4), DFFA(4), DFFB(2), FAS(1), FASLG(2), IKBKB(6), IL1A(1), IL1R1(1), IL1RAP(10), IL3(1), IL3RA(3), IRAK1(5), IRAK2(4), IRAK3(2), IRAK4(3), MYD88(1), NFKB1(5), NFKB2(5), NFKBIA(3), NTRK1(8), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PPP3CA(5), PPP3CB(3), PPP3CC(1), PPP3R1(1), PRKACA(4), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), RELA(3), RIPK1(5), TNFRSF10A(1), TNFRSF10B(1), TNFRSF10D(1), TNFRSF1A(4), TRAF2(1) 110416201 246 160 243 47 35 72 44 41 54 0 0.00997 1.000 1.000 374 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 68 ACACB(13), ACSL1(3), ACSL3(3), ACSL4(5), ACSL5(5), ACSL6(4), ADIPOR1(1), ADIPOR2(2), AGRP(1), AKT1(2), AKT2(5), AKT3(4), CAMKK1(3), CAMKK2(4), CD36(5), CHUK(8), CPT1A(6), CPT1B(4), CPT1C(7), CPT2(5), G6PC(2), G6PC2(3), IKBKB(6), IRS1(4), IRS4(7), JAK1(11), JAK2(7), JAK3(8), LEP(1), LEPR(7), MAPK10(4), MAPK8(2), MAPK9(1), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), NPY(1), PCK1(5), PCK2(4), PPARA(4), PPARGC1A(6), PRKAA1(3), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKAG1(2), PRKAG2(2), PRKAG3(3), PRKCQ(9), PTPN11(1), RELA(3), RXRA(2), RXRG(2), SLC2A4(3), STAT3(5), STK11(2), TNFRSF1A(4), TNFRSF1B(2), TRAF2(1), TYK2(8) 113465716 246 154 243 67 48 55 41 46 54 2 0.394 1.000 1.000 375 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 48 ADORA3(1), ALG6(2), CCKBR(2), CCR2(7), CCR3(2), CCR5(1), CELSR1(14), CELSR2(14), CELSR3(12), CHRM2(6), CHRM3(3), CIDEB(2), CXCR3(6), EDNRA(3), EMR2(9), EMR3(7), F2R(4), FSHR(9), GHRHR(5), GPR116(7), GPR132(1), GPR133(6), GPR135(1), GPR143(4), GPR17(2), GPR55(3), GPR56(3), GPR61(2), GPR77(2), GPR84(7), GRM1(9), GRPR(3), HRH4(2), LGR6(5), LPHN2(11), LPHN3(8), P2RY13(4), PTGFR(1), SMO(5), SSTR2(1), TAAR5(4), TSHR(7), VN1R1(1) 87242127 208 145 208 64 29 53 33 56 37 0 0.311 1.000 1.000 376 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 60 AKT1(2), AKT2(5), AKT3(4), BCL10(3), BLNK(1), BTK(7), CARD11(7), CD19(6), CD22(5), CD72(5), CD79B(2), CHUK(8), CR2(5), FOS(1), GSK3B(2), HRAS(2), IFITM1(1), IKBKB(6), INPP5D(4), JUN(3), LILRB3(6), LYN(6), MALT1(3), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), NRAS(2), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLCG2(8), PPP3CA(5), PPP3CB(3), PPP3CC(1), PPP3R1(1), PTPN6(2), RASGRP3(2), SYK(4), VAV1(6), VAV2(3), VAV3(7) 98035587 219 145 218 67 39 57 35 46 42 0 0.673 1.000 1.000 377 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 84 AK3(2), CAD(17), CANT1(2), CDA(1), CTPS2(3), DCK(1), DPYD(2), DPYS(3), DTYMK(2), DUT(1), ENTPD1(4), ENTPD3(1), ENTPD4(4), ENTPD5(7), ENTPD6(4), ENTPD8(1), ITPA(1), NME6(1), NME7(4), NT5C1A(2), NT5C1B(6), NT5C2(3), NT5C3(4), NT5E(6), NUDT2(1), PNPT1(5), POLA1(15), POLA2(6), POLD1(5), POLD2(1), POLE(10), POLE2(2), POLE3(1), POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2D(1), POLR2F(5), POLR2G(1), POLR2H(1), POLR2J(1), POLR3A(5), POLR3B(2), POLR3GL(3), POLR3H(1), POLR3K(1), PRIM1(1), RFC5(1), RRM1(4), RRM2(1), RRM2B(1), TK1(1), TK2(1), TXNRD1(6), TXNRD2(3), TYMS(1), UCK1(1), UCK2(2), UMPS(4), UPB1(3), UPP1(3), UPRT(3) 115776082 217 143 215 66 36 62 38 49 31 1 0.724 1.000 1.000 378 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 45 FN3K(3), IMPA1(3), IMPA2(4), INPP1(1), INPP4A(5), INPP4B(7), INPP5A(2), INPP5B(7), INPP5E(1), INPPL1(6), IPMK(1), ISYNA1(1), ITPK1(1), ITPKA(1), ITPKB(8), MINPP1(3), OCRL(8), PI4KA(10), PI4KB(6), PIK3C3(6), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIP4K2A(2), PIP4K2C(6), PIP5K1A(6), PIP5K1B(2), PIP5K1C(5), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), PLCD1(3), PLCD3(2), PLCD4(6), PLCE1(15), PLCG1(8), PLCG2(8), PLCZ1(11), SYNJ1(4), SYNJ2(4) 100084930 223 143 222 51 41 56 36 40 49 1 0.0898 1.000 1.000 379 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 70 AKT1(2), AKT2(5), AKT3(4), BTK(7), FCER1A(4), GAB2(5), HRAS(2), IL3(1), IL4(1), INPP5D(4), LAT(1), LCP2(2), LYN(6), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K6(1), MAP2K7(1), MAPK1(1), MAPK10(4), MAPK13(1), MAPK14(2), MAPK3(1), MAPK8(2), MAPK9(1), MS4A2(3), NRAS(2), PDK1(2), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLCG1(8), PLCG2(8), PRKCA(4), PRKCD(5), PRKCE(8), RAF1(4), SOS1(5), SOS2(6), SYK(4), VAV1(6), VAV2(3), VAV3(7) 94166052 193 137 193 47 33 47 32 43 38 0 0.182 1.000 1.000 380 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 44 AKT1(2), AKT2(5), AKT3(4), BAD(1), BCR(3), BLNK(1), BTK(7), CD19(6), CD22(5), CR2(5), DAG1(2), FLOT1(2), FLOT2(3), GSK3A(5), GSK3B(2), INPP5D(4), ITPR1(15), ITPR2(18), ITPR3(14), LYN(6), MAP4K1(10), MAPK1(1), MAPK3(1), NFATC1(5), NFATC2(4), NR0B2(2), PDK1(2), PIK3CD(6), PLCG2(8), PPP1R13B(4), PPP3CA(5), PPP3CB(3), PPP3CC(1), PTPRC(8), RAF1(4), SHC1(2), SOS1(5), SOS2(6), SYK(4), VAV1(6) 97742845 197 133 196 52 37 50 28 55 27 0 0.200 1.000 1.000 381 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 62 APAF1(11), ATM(23), ATR(13), BAI1(10), BAX(3), BBC3(2), BID(4), CASP3(1), CASP9(3), CCNB1(3), CCNB3(14), CCND1(1), CCND2(3), CCND3(5), CCNE1(2), CCNE2(4), CCNG2(2), CDK2(2), CDK4(1), CDK6(2), CDKN1A(1), CDKN2A(1), CHEK1(2), CHEK2(6), DDB2(2), EI24(3), FAS(1), GTSE1(10), IGFBP3(1), MDM2(3), MDM4(3), PERP(1), PMAIP1(2), PPM1D(2), RCHY1(2), RFWD2(4), RPRM(1), RRM2(1), RRM2B(1), SERPINE1(5), SESN2(2), SESN3(1), SFN(1), SIAH1(3), STEAP3(2), THBS1(8), TNFRSF10B(1), TP53I3(3), TP73(2), TSC2(8) 87114472 192 132 189 38 29 55 26 32 49 1 0.0967 1.000 1.000 382 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(6), ADCY6(2), ADCY8(6), CACNA1A(16), CACNA1B(14), GNAS(11), GNAT3(1), GNB1(2), GNB3(3), GRM4(3), ITPR3(14), KCNB1(7), PDE1A(5), PLCB2(7), PRKACA(4), PRKACB(1), PRKACG(3), PRKX(5), SCNN1A(3), SCNN1B(2), SCNN1G(1), TAS1R1(3), TAS1R2(4), TAS1R3(1), TAS2R1(4), TAS2R10(4), TAS2R13(2), TAS2R14(2), TAS2R16(5), TAS2R3(3), TAS2R38(2), TAS2R39(1), TAS2R40(2), TAS2R41(2), TAS2R42(2), TAS2R43(4), TAS2R46(2), TAS2R5(2), TAS2R50(1), TAS2R8(2), TAS2R9(2), TRPM5(10) 80411911 176 130 174 46 37 44 32 34 29 0 0.120 1.000 1.000 383 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 59 AKT1(2), AKT2(5), AKT3(4), BAD(1), BCL2L1(1), CDK2(2), CDKN2A(1), CREB1(2), CREB3(1), CREB5(4), EBP(1), ERBB4(14), F2RL2(2), GAB1(2), GSK3A(5), GSK3B(2), INPPL1(6), IRS1(4), IRS4(7), MET(10), MYC(1), NOLC1(2), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PAK7(4), PARD3(8), PARD6A(1), PDK1(2), PIK3CD(6), PPP1R13B(4), PREX1(10), PTK2(7), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), RPS6KB1(4), SFN(1), SHC1(2), SLC2A4(3), SOS1(5), SOS2(6), TSC1(5), TSC2(8), YWHAB(2), YWHAG(1), YWHAZ(3) 100468418 200 130 199 58 34 55 32 38 40 1 0.641 1.000 1.000 384 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 66 AKT1(2), AKT2(5), AKT3(4), BAD(1), CASP9(3), HRAS(2), KDR(8), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK13(1), MAPK14(2), MAPK3(1), MAPKAPK2(1), MAPKAPK3(2), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), NOS3(3), NRAS(2), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLCG1(8), PLCG2(8), PPP3CA(5), PPP3CB(3), PPP3CC(1), PPP3R1(1), PRKCA(4), PRKCG(3), PTGS2(5), PTK2(7), RAF1(4), SH2D2A(4), SHC2(3), SPHK1(1), SPHK2(3), SRC(1), VEGFA(1) 93162412 190 128 190 66 34 50 38 39 29 0 0.868 1.000 1.000 385 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 92 ANK2(28), B3GALT4(2), CDR1(2), DGKI(7), IL6ST(9), RPL10(2), RPL12(1), RPL13A(4), RPL15(1), RPL18(1), RPL18A(4), RPL19(2), RPL23(1), RPL24(1), RPL26(1), RPL3(4), RPL31(1), RPL32(1), RPL35(1), RPL36(1), RPL3L(3), RPL4(1), RPL41(1), RPL5(2), RPL7(1), RPL8(2), RPL9(1), RPLP0(2), RPLP2(1), RPS10(1), RPS12(1), RPS14(1), RPS16(1), RPS18(1), RPS2(1), RPS25(1), RPS27(1), RPS29(1), RPS4X(2), RPS5(6), RPS6(4), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), RPS6KA6(6), RPS6KB1(4), RPS6KB2(5), RPS8(1), RPS9(2), SLC36A2(5), TBC1D10C(4), TSPAN9(3), UBA52(2), UBC(13) 75106080 174 126 172 47 38 49 32 29 25 1 0.480 1.000 1.000 386 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(1), ADH1C(4), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), AGK(4), AGPAT1(1), AGPAT3(2), AGPAT4(2), AGPAT6(3), AKR1A1(1), AKR1B1(3), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), CEL(4), DAK(4), DGAT1(2), DGAT2(2), DGKA(2), DGKB(5), DGKD(10), DGKE(4), DGKG(8), DGKH(4), DGKI(7), DGKQ(2), DGKZ(1), GK(6), GK2(4), GLA(5), GLB1(4), GPAM(6), LCT(17), LIPA(4), LIPC(2), LIPF(1), LIPG(3), LPL(1), MGLL(2), PNLIP(5), PNLIPRP1(4), PNLIPRP2(1), PNPLA3(3), PPAP2A(2), PPAP2C(1) 83683793 177 125 175 43 35 35 40 33 33 1 0.0923 1.000 1.000 387 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(23), AXIN1(5), CCND1(1), CCND2(3), CCND3(5), CSNK1E(4), CTNNB1(2), DVL1(2), DVL3(1), FBXW2(4), FZD1(3), FZD10(4), FZD2(4), FZD3(5), FZD5(1), FZD6(4), FZD7(3), FZD8(1), FZD9(3), GSK3B(2), JUN(3), LDLR(6), MAPK10(4), MAPK9(1), MYC(1), PAFAH1B1(3), PLAU(4), PPP2R5C(6), PPP2R5E(2), PRKCA(4), PRKCD(5), PRKCE(8), PRKCG(3), PRKCH(3), PRKCI(1), PRKCQ(9), PRKCZ(2), PRKD1(6), RHOA(6), SFRP4(2), TCF7(4), WNT10B(1), WNT11(1), WNT16(2), WNT2(1), WNT2B(4), WNT3(1), WNT4(1), WNT5B(4), WNT6(1), WNT7A(6), WNT7B(1) 80062020 186 125 185 52 45 39 29 35 34 4 0.507 1.000 1.000 388 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 60 ATM(23), CCNB1(3), CCND1(1), CCND2(3), CCND3(5), CCNE1(2), CCNE2(4), CCNG2(2), CCNH(2), CDC25A(1), CDK2(2), CDK4(1), CDK7(3), CDKN1A(1), CDKN2A(1), CREB3(1), CREB3L1(3), CREB3L3(8), CREB3L4(2), E2F1(5), E2F3(3), E2F4(2), E2F6(2), GBA2(4), MCM2(5), MCM3(4), MCM4(5), MCM5(3), MCM6(4), MCM7(7), MDM2(3), MNAT1(2), MYC(1), MYT1(10), NACA(8), POLA2(6), POLE(10), POLE2(2), PRIM1(1), RBL1(6), RPA1(1), RPA2(2), RPA3(2), TFDP1(3), TFDP2(4), TNXB(16), WEE1(4) 100629514 193 123 190 46 31 58 26 41 36 1 0.281 1.000 1.000 389 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(6), AMY2A(5), AMY2B(1), ENPP1(7), ENPP3(6), G6PC(2), GAA(2), GANAB(10), GBA3(4), GBE1(4), GCK(3), GPI(3), GUSB(6), GYS1(8), GYS2(1), HK1(3), HK2(5), HK3(5), MGAM(22), PGM1(5), PGM3(2), PYGB(5), PYGL(3), PYGM(5), RNPC3(2), SI(18), UCHL3(2), UGDH(1), UGT1A1(4), UGT1A10(3), UGT1A3(3), UGT1A4(4), UGT1A6(2), UGT1A7(3), UGT1A8(2), UGT1A9(2), UGT2B15(5), UGT2B4(3), UXS1(3) 82974920 180 123 179 69 28 40 33 55 24 0 0.982 1.000 1.000 390 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 66 ACAA1(1), ACADL(1), ACOX1(4), ACOX2(4), ACOX3(5), ACSL1(3), ACSL3(3), ACSL4(5), ACSL5(5), ACSL6(4), ANGPTL4(1), APOA1(3), APOA5(3), AQP7(1), CD36(5), CPT1A(6), CPT1B(4), CPT1C(7), CPT2(5), CYP27A1(1), CYP4A11(8), CYP4A22(2), CYP7A1(3), CYP8B1(3), DBI(1), EHHADH(4), FABP1(2), FABP2(1), FABP3(1), FABP6(1), FABP7(1), FADS2(7), GK(6), GK2(4), HMGCS2(3), ILK(3), LPL(1), MMP1(2), NR1H3(2), OLR1(2), PCK1(5), PCK2(4), PDPK1(2), PLTP(3), PPARA(4), PPARD(2), PPARG(5), RXRA(2), RXRG(2), SCD(1), SCP2(1), SLC27A1(2), SLC27A2(2), SLC27A4(6), SLC27A5(4), SORBS1(7), UBC(13) 91423213 193 122 192 64 32 49 38 46 27 1 0.793 1.000 1.000 391 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 APH1A(2), CREBBP(15), CTBP1(1), CTBP2(1), DLL1(5), DLL3(2), DLL4(2), DTX1(4), DTX2(3), DTX3(3), DTX3L(4), DTX4(2), DVL1(2), DVL3(1), EP300(13), HDAC1(5), HDAC2(2), HES1(1), JAG1(9), JAG2(1), MAML1(3), MAML2(4), MAML3(7), NCOR2(8), NCSTN(7), NOTCH1(8), NOTCH2(18), NOTCH3(11), NOTCH4(13), NUMB(5), NUMBL(3), PSEN1(2), PSEN2(4), PSENEN(2), PTCRA(3), RBPJL(5), RFNG(2), SNW1(2) 90067017 185 122 184 69 41 35 39 31 39 0 0.975 1.000 1.000 392 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 68 B2M(3), CALR(1), CANX(3), CD4(4), CD74(2), CD8A(3), CD8B(3), CIITA(5), CREB1(2), CTSB(2), CTSL1(4), CTSS(3), HLA-A(3), HLA-B(6), HLA-DMA(1), HLA-DMB(3), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(3), HLA-DRB1(10), HLA-F(5), HLA-G(1), HSP90AA1(3), HSP90AB1(5), HSPA5(5), IFI30(1), IFNA1(1), IFNA10(3), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(3), IFNA2(3), IFNA21(4), IFNA4(2), IFNA6(1), IFNA7(2), IFNA8(2), KIR2DL1(3), KIR2DL3(3), KIR2DL4(4), KIR2DS4(4), KIR3DL1(3), KIR3DL2(6), KIR3DL3(3), KLRC1(5), KLRC3(1), KLRD1(1), LGMN(2), LTA(2), NFYB(1), NFYC(4), PSME1(1), RFX5(3), RFXANK(3), RFXAP(1), TAP1(2) 55654023 165 122 164 48 17 48 48 27 24 1 0.563 1.000 1.000 393 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 41 ACTR2(2), ACTR3(2), AKT1(2), AKT2(5), AKT3(4), ANGPTL2(1), ARHGAP1(4), ARHGAP4(6), ARHGEF11(6), BTK(7), CFL1(1), CFL2(1), GDI1(3), GDI2(2), INPPL1(6), ITPR1(15), ITPR2(18), ITPR3(14), LIMK1(8), MYLK(11), MYLK2(5), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PAK7(4), PDK1(2), PIK3CD(6), PIK3CG(5), PITX2(5), PPP1R13B(4), RACGAP1(3), RHO(2), ROCK1(8), ROCK2(9), RPS4X(2), SAG(3), WASF1(6), WASL(4) 93512708 205 122 203 63 37 51 35 44 37 1 0.718 1.000 1.000 394 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(3), ATP6AP1(2), ATP6V0A1(6), ATP6V0A2(3), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V0D2(2), ATP6V0E1(2), ATP6V1A(4), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1E2(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), CASP3(1), CHUK(8), EGFR(5), F11R(4), GIT1(3), IGSF5(3), IKBKB(6), IL8(1), JAM2(1), JUN(3), LYN(6), MAPK10(4), MAPK13(1), MAPK14(2), MAPK8(2), MAPK9(1), MET(10), NFKB1(5), NFKB2(5), NFKBIA(3), NOD1(6), PAK1(4), PLCG1(8), PLCG2(8), PTPN11(1), PTPRZ1(11), RELA(3), SRC(1), TCIRG1(4), TJP1(8) 100356991 179 121 177 53 33 53 28 23 42 0 0.643 1.000 1.000 395 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 65 AGTR1(4), AGTR2(2), ATP8A1(4), AVPR1B(5), AVPR2(3), BDKRB1(4), BDKRB2(4), BRS3(4), C3AR1(3), CCKAR(3), CCKBR(2), CCR1(3), CCR2(7), CCR3(2), CCR4(1), CCR5(1), CCR6(1), CCR7(4), CCR8(1), CX3CR1(3), CXCR3(6), CXCR4(3), CXCR6(1), EDNRA(3), EDNRB(2), FPR1(3), FSHR(9), GALR1(1), GALR2(2), GALR3(1), GALT(2), GHSR(2), GNB2L1(5), GPR77(2), GRPR(3), LHCGR(10), MC2R(2), MC3R(3), MC4R(2), NMBR(3), NPY1R(5), NPY2R(3), NTSR2(2), OPRD1(3), OPRK1(2), OPRL1(3), OPRM1(5), OXTR(1), PPYR1(4), SSTR2(1), SSTR3(2), SSTR4(1), TACR1(2), TACR2(4), TACR3(2), TSHR(7) 71625023 173 120 173 50 31 45 29 48 19 1 0.107 1.000 1.000 396 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AANAT(1), ABP1(1), ACAT1(3), AFMID(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), AOC2(6), AOC3(3), AOX1(7), ASMT(1), CARM1(5), CAT(2), CYP1A1(1), CYP1A2(2), CYP1B1(2), DDC(4), EHHADH(4), GCDH(2), HAAO(2), HADH(2), HADHA(3), HEMK1(2), HSD17B10(1), HSD17B4(8), INMT(4), KMO(8), KYNU(3), LCMT1(1), LCMT2(10), LNX1(6), MAOA(2), MAOB(4), METTL2B(4), METTL6(1), NFX1(4), OGDH(7), OGDHL(6), PRMT2(5), PRMT3(3), PRMT5(6), PRMT6(2), PRMT7(3), PRMT8(4), TDO2(2), TPH1(3), TPH2(4), WARS2(2), WBSCR22(2) 86417772 176 119 175 58 24 53 42 30 25 2 0.809 1.000 1.000 397 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(3), AGPAT1(1), AGPAT3(2), AGPAT4(2), AGPAT6(3), CDS1(3), CDS2(3), CHAT(2), CHKA(1), CHKB(5), CHPT1(4), CRLS1(3), DGKA(2), DGKB(5), DGKD(10), DGKE(4), DGKG(8), DGKH(4), DGKI(7), DGKQ(2), DGKZ(1), ESCO1(4), ESCO2(1), ETNK1(4), ETNK2(4), GNPAT(5), GPAM(6), GPD1(6), GPD1L(1), GPD2(3), LCAT(1), PCYT1A(2), PCYT1B(6), PEMT(1), PHOSPHO1(1), PISD(1), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLD1(7), PLD2(2), PNPLA3(3), PPAP2A(2), PPAP2C(1), PTDSS1(5), PTDSS2(3), SH3GLB1(2) 92670771 165 118 164 45 27 38 29 44 26 1 0.327 1.000 1.000 398 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 31 AKT1(2), AKT2(5), AKT3(4), BCR(3), BTK(7), CD19(6), CDKN2A(1), DAPP1(2), FLOT1(2), FLOT2(3), GAB1(2), ITPR1(15), ITPR2(18), ITPR3(14), LYN(6), NR0B2(2), PDK1(2), PHF11(3), PITX2(5), PLCG2(8), PPP1R13B(4), PREX1(10), PTPRC(8), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), RPS6KB1(4), SAG(3), SYK(4), TEC(6), VAV1(6) 74625418 175 118 173 37 37 40 26 43 29 0 0.0281 1.000 1.000 399 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(3), BMP4(2), BMP5(4), BMP6(2), BMP8B(2), BTRC(4), CSNK1A1(4), CSNK1A1L(4), CSNK1E(4), CSNK1G1(1), CSNK1G2(2), CSNK1G3(1), GLI1(5), GLI2(12), GLI3(11), GSK3B(2), HHIP(1), IHH(2), LRP2(33), PRKACA(4), PRKACB(1), PRKACG(3), PRKX(5), PTCH1(11), PTCH2(2), SHH(1), SMO(5), STK36(1), SUFU(3), WNT10B(1), WNT11(1), WNT16(2), WNT2(1), WNT2B(4), WNT3(1), WNT3A(1), WNT4(1), WNT5B(4), WNT6(1), WNT7A(6), WNT7B(1), WNT8B(2), WNT9A(1), ZIC2(1) 80608756 163 117 162 54 48 38 26 32 19 0 0.729 1.000 1.000 400 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(2), AKT2(5), AKT3(4), ASAH1(1), BRAF(5), DAG1(2), DRD2(3), EGFR(5), EPHB2(5), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), KCNJ3(2), KCNJ5(1), KCNJ9(1), MAPK1(1), PI3(1), PIK3CB(8), PITX2(5), PLCB1(13), PLCB2(7), PLCB3(2), PLCB4(16), RAF1(4), RGS20(4), SHC1(2), SOS1(5), SOS2(6), SRC(1), STAT3(5), TERF2IP(3) 83303492 175 117 173 41 30 46 19 49 31 0 0.110 1.000 1.000 401 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASDHPPT(4), AASS(5), ACAT1(3), AKR1B10(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), BBOX1(2), DLST(3), DOT1L(10), EHHADH(4), EHMT1(9), EHMT2(6), GCDH(2), HADH(2), HADHA(3), HSD17B10(1), HSD17B4(8), HSD3B7(1), NSD1(13), OGDH(7), OGDHL(6), PIPOX(2), PLOD1(2), PLOD2(2), PLOD3(9), RDH11(4), RDH12(2), RDH13(2), RDH14(2), SETD1A(4), SETD7(5), SETDB1(11), SHMT1(1), SHMT2(4), SPCS3(1), SUV39H1(2), SUV39H2(1), TMLHE(1) 79094475 162 116 159 46 25 42 40 32 23 0 0.504 1.000 1.000 402 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPL(1), ALPP(3), ALPPL2(2), ASCC3(7), ATP13A2(3), DDX18(3), DDX19A(1), DDX23(4), DDX4(6), DDX41(5), DDX47(1), DDX50(4), DDX51(3), DDX52(2), DDX54(3), DDX55(7), DDX56(2), DHX58(4), ENTPD7(6), EP400(13), ERCC2(3), ERCC3(5), FPGS(4), GCH1(1), IFIH1(4), MOV10L1(7), NUDT5(2), NUDT8(1), QDPR(1), RAD54B(9), RAD54L(3), RUVBL2(1), SETX(18), SKIV2L2(5), SMARCA2(11), SMARCA5(5) 88654516 160 115 160 35 25 46 29 33 27 0 0.112 1.000 1.000 403 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 54 ABP1(1), ADH1A(1), ADH1C(4), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), ALDH1A3(7), ALDH3A1(3), ALDH3B2(4), AOC2(6), AOC3(3), AOX1(7), CARM1(5), COMT(1), DBH(6), DCT(4), DDC(4), ECH1(1), ESCO1(4), ESCO2(1), FAH(3), GOT1(2), GOT2(1), GSTZ1(1), HEMK1(2), HGD(4), HPD(4), LCMT1(1), LCMT2(10), MAOA(2), MAOB(4), METTL2B(4), METTL6(1), PNMT(1), PNPLA3(3), PRMT2(5), PRMT3(3), PRMT5(6), PRMT6(2), PRMT7(3), PRMT8(4), SH3GLB1(2), TAT(3), TH(2), TPO(8), TYR(5), TYRP1(7), WBSCR22(2) 82655347 170 113 167 40 31 40 41 26 30 2 0.188 1.000 1.000 404 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 53 ALG2(2), BAK1(3), BAX(3), BFAR(3), BTK(7), CAD(17), CASP10(2), CASP3(1), CD7(1), CSNK1A1(4), DAXX(2), DEDD(1), DEDD2(1), DFFA(4), DIABLO(1), EGFR(5), EPHB2(5), FAF1(7), IL1A(1), IL8(1), MAP2K7(1), MAP3K5(12), MAPK1(1), MAPK10(4), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(8), MAPK9(1), MET(10), NFAT5(7), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), NR0B2(2), PTPN13(16), RALBP1(3), RIPK1(5), ROCK1(8), SMPD1(2), TNFRSF6B(1), TPX2(2), TRAF2(1), TUFM(3) 89218438 180 113 177 43 34 53 26 32 34 1 0.231 1.000 1.000 405 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 42 AKT1(2), AKT2(5), AKT3(4), BRAF(5), CAB39(1), DDIT4(1), EIF4B(2), FIGF(3), HIF1A(4), MAPK1(1), MAPK3(1), PDPK1(2), PGF(5), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R2(4), PIK3R3(3), PIK3R5(5), PRKAA1(3), PRKAA2(2), RHEB(1), RICTOR(7), RPS6(4), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), RPS6KA6(6), RPS6KB1(4), RPS6KB2(5), STK11(2), TSC1(5), TSC2(8), ULK1(5), ULK2(6), ULK3(5), VEGFA(1), VEGFC(2) 68263902 153 111 152 34 25 48 22 26 32 0 0.185 1.000 1.000 406 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(9), COL4A2(9), COL4A3(6), COL4A4(9), COL4A5(12), COL4A6(10), F10(5), F12(2), F2(2), F2R(4), F5(26), F8(20), F9(1), FGA(7), FGB(1), FGG(7), KLKB1(5), PROC(3), PROS1(4), SERPINC1(6), SERPING1(3) 64590142 151 110 151 38 22 35 41 29 24 0 0.309 1.000 1.000 407 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 25 BRAF(5), CPEB1(7), EGFR(5), ERBB4(14), ETS1(3), ETS2(7), ETV6(4), ETV7(3), FMN2(17), MAP2K1(5), MAPK1(1), MAPK3(1), NOTCH1(8), NOTCH2(18), NOTCH3(11), NOTCH4(13), PIWIL2(5), PIWIL3(7), PIWIL4(4), RAF1(4), SOS1(5), SOS2(6), SPIRE1(2) 62406144 155 108 152 44 14 39 34 40 27 1 0.696 1.000 1.000 408 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(3), AKT1(2), BDKRB2(4), CALM2(2), CAV1(4), CHRM1(4), CHRNA1(4), FLT1(5), FLT4(3), KDR(8), NOS3(3), PDE2A(4), PDE3A(12), PDE3B(4), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKG1(5), PRKG2(8), RYR2(53), SYT1(2) 58864376 145 108 144 64 20 42 30 31 20 2 0.995 1.000 1.000 409 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 45 ACOX1(4), APOA1(3), CD36(5), CITED2(2), CPT1B(4), CREBBP(15), DUSP1(1), DUT(1), EHHADH(4), EP300(13), FABP1(2), HSD17B4(8), JUN(3), LPL(1), MAPK1(1), MAPK3(1), MRPL11(2), MYC(1), NCOA1(5), NCOR2(8), NFKBIA(3), NR0B2(2), NR1H3(2), NR2F1(1), NRIP1(10), PPARA(4), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKCA(4), PTGS2(5), RELA(3), RXRA(2), SP1(6), SRA1(1), STAT5A(6), STAT5B(5) 72881706 153 108 153 37 27 36 23 28 38 1 0.290 1.000 1.000 410 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 32 AKT1(2), APC(23), AR(6), ASAH1(1), BRAF(5), CCL13(4), CCL15(1), DAG1(2), EGFR(5), GNA11(4), GNAI1(2), GNAQ(1), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), KCNJ3(2), KCNJ5(1), KCNJ9(1), MAPK1(1), MAPK10(4), MAPK14(2), PHKA2(13), PIK3CD(6), PITX2(5), PTX3(1), RAF1(4), SRC(1) 70594519 153 108 151 39 25 41 17 46 23 1 0.254 1.000 1.000 411 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 42 CBL(4), CD28(2), CTLA4(1), DAG1(2), DTYMK(2), EPHB2(5), GRAP2(2), ITK(7), ITPKA(1), ITPKB(8), LAT(1), LCK(2), LCP2(2), MAPK1(1), NCK1(2), NFAT5(7), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PAK7(4), PLCG1(8), PTPRC(8), RAF1(4), RASGRP2(6), RASGRP3(2), RASGRP4(5), SOS1(5), SOS2(6), VAV1(6), ZAP70(3) 75647715 142 108 142 55 26 38 19 32 27 0 0.983 1.000 1.000 412 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(3), ATP4A(8), ATP4B(3), ATP5A1(4), ATP5B(1), ATP5C1(1), ATP5F1(3), ATP5G2(2), ATP5L(1), ATP5O(2), ATP6AP1(2), ATP6V0A1(6), ATP6V0A2(3), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V0D2(2), ATP6V0E1(2), ATP6V1A(4), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1E2(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), COX10(7), COX15(3), COX17(2), COX4I2(2), COX5A(1), COX5B(1), COX6A1(1), COX6C(1), COX7A2(2), COX7B2(3), NDUFA1(2), NDUFA10(1), NDUFA13(1), NDUFA2(1), NDUFA4(1), NDUFA4L2(1), NDUFA6(1), NDUFA7(1), NDUFA9(3), NDUFB1(2), NDUFB10(1), NDUFB3(1), NDUFB5(4), NDUFB6(2), NDUFB8(1), NDUFB9(3), NDUFS1(1), NDUFS2(7), NDUFS3(1), NDUFS5(1), NDUFS6(1), NDUFS7(2), NDUFS8(1), NDUFV1(5), NDUFV2(1), NDUFV3(5), PPA1(4), PPA2(2), SDHB(2), SDHD(1), TCIRG1(4), UQCRB(1), UQCRC1(1), UQCRC2(4), UQCRFS1(1) 80638428 170 107 170 41 29 48 28 36 29 0 0.118 1.000 1.000 413 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(1), ADH1C(4), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), AKR1C1(5), AKR1C2(3), AKR1C3(1), AKR1C4(3), ALDH1A3(7), ALDH3A1(3), ALDH3B2(4), CYP1A1(1), CYP1A2(2), CYP1B1(2), CYP2B6(5), CYP2C18(2), CYP2C19(6), CYP2C8(3), CYP2C9(3), CYP2E1(2), CYP2F1(5), CYP2S1(6), CYP3A4(4), CYP3A43(3), CYP3A5(2), CYP3A7(5), DHDH(1), EPHX1(3), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTK1(3), GSTM4(2), GSTM5(1), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(1), MGST3(2), UGT1A1(4), UGT1A10(3), UGT1A3(3), UGT1A4(4), UGT1A6(2), UGT1A7(3), UGT1A8(2), UGT1A9(2), UGT2A1(7), UGT2B10(3), UGT2B11(1), UGT2B15(5), UGT2B17(2), UGT2B28(3), UGT2B4(3), UGT2B7(3) 81645445 169 107 167 55 18 45 36 47 23 0 0.716 1.000 1.000 414 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 50 ACTA1(3), AGT(3), AKT1(2), CALM2(2), CALR(1), CAMK1(1), CAMK1G(5), CAMK4(5), CREBBP(15), CSNK1A1(4), EDN1(5), F2(2), GATA4(2), GSK3B(2), HAND2(4), HRAS(2), LIF(2), MAP2K1(5), MAPK1(1), MAPK14(2), MAPK3(1), MAPK8(2), MEF2C(4), MYH2(9), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), NKX2-5(1), NPPA(1), PPP3CA(5), PPP3CB(3), PPP3CC(1), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), RAF1(4), RPS6KB1(4), SYT1(2) 65396071 146 106 146 43 22 39 30 34 20 1 0.530 1.000 1.000 415 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 AK3(2), CAD(17), CANT1(2), CDA(1), CTPS2(3), DCK(1), DPYD(2), DPYS(3), DTYMK(2), DUT(1), ENTPD1(4), ITPA(1), NT5E(6), NUDT2(1), POLB(1), POLD1(5), POLD2(1), POLE(10), POLG(7), POLL(3), POLQ(12), POLR1B(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2D(1), POLR2F(5), POLR2G(1), POLR2H(1), POLR2J(1), POLRMT(5), RRM1(4), RRM2(1), TK1(1), TK2(1), TXNRD1(6), TYMS(1), UCK1(1), UCK2(2), UMPS(4), UPB1(3), UPP1(3) 80973631 142 106 140 48 23 42 21 29 26 1 0.894 1.000 1.000 416 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(14), CARM1(5), CCND1(1), CREBBP(15), EP300(13), ERCC3(5), ESR1(7), GRIP1(7), GTF2A1(2), GTF2E1(2), GTF2F1(1), HDAC1(5), HDAC2(2), HDAC3(1), HDAC4(6), HDAC5(6), HDAC6(16), MEF2C(4), NCOR2(8), NRIP1(10), PELP1(7), POLR2A(6), SRA1(1), TBP(2) 66529685 146 105 145 41 20 34 26 30 36 0 0.694 1.000 1.000 417 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 63 ACSS1(1), ACSS2(2), ACYP1(2), ADH1A(1), ADH1C(4), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), AKR1A1(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH3B2(4), ALDH9A1(1), ALDOA(5), ALDOB(3), ALDOC(2), BPGM(1), DLAT(2), DLD(1), ENO2(1), ENO3(2), FBP1(2), G6PC(2), G6PC2(3), GALM(1), GAPDH(1), GAPDHS(2), GCK(3), GPI(3), HK1(3), HK2(5), HK3(5), LDHA(3), LDHC(4), PDHA1(2), PDHA2(4), PDHB(1), PFKL(1), PFKM(8), PFKP(7), PGAM2(1), PGAM4(2), PGK1(6), PGK2(1), PGM1(5), PGM3(2), PKLR(5), TPI1(2) 81976631 146 104 143 33 21 37 35 31 22 0 0.0574 1.000 1.000 418 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 52 AKR1C4(3), AKR1D1(1), ARSE(4), CARM1(5), CYP11B1(5), CYP11B2(4), HEMK1(2), HSD11B1(3), HSD11B2(2), HSD17B1(1), HSD17B2(4), HSD17B3(2), HSD17B7(1), HSD3B1(3), HSD3B2(4), LCMT1(1), LCMT2(10), METTL2B(4), METTL6(1), PRMT2(5), PRMT3(3), PRMT5(6), PRMT6(2), PRMT7(3), PRMT8(4), SRD5A1(4), STS(1), SULT1E1(4), SULT2B1(2), UGT1A1(4), UGT1A10(3), UGT1A3(3), UGT1A4(4), UGT1A6(2), UGT1A7(3), UGT1A8(2), UGT1A9(2), UGT2A1(7), UGT2B10(3), UGT2B11(1), UGT2B15(5), UGT2B17(2), UGT2B28(3), UGT2B4(3), UGT2B7(3), WBSCR22(2) 69242281 146 103 145 47 14 45 33 30 23 1 0.727 1.000 1.000 419 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 48 ABL1(7), ACTB(5), ARHGEF2(5), ARPC5(1), ARPC5L(3), CD14(1), CLDN1(1), CTNNB1(2), CTTN(2), EZR(1), HCLS1(2), ITGB1(5), KRT18(3), NCK1(2), NCK2(1), NCL(7), OCLN(3), PRKCA(4), RHOA(6), ROCK1(8), ROCK2(9), TLR4(15), TLR5(4), TUBA1A(3), TUBA1B(2), TUBA1C(4), TUBA3C(4), TUBA3D(3), TUBA3E(3), TUBA4A(1), TUBA8(1), TUBAL3(2), TUBB(2), TUBB1(4), TUBB2B(3), TUBB3(2), TUBB6(2), TUBB8(5), WAS(6), WASL(4), YWHAZ(3) 69304726 151 101 147 55 28 48 23 29 23 0 0.947 1.000 1.000 420 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 48 ABL1(7), ACTB(5), ARHGEF2(5), ARPC5(1), ARPC5L(3), CD14(1), CLDN1(1), CTNNB1(2), CTTN(2), EZR(1), HCLS1(2), ITGB1(5), KRT18(3), NCK1(2), NCK2(1), NCL(7), OCLN(3), PRKCA(4), RHOA(6), ROCK1(8), ROCK2(9), TLR4(15), TLR5(4), TUBA1A(3), TUBA1B(2), TUBA1C(4), TUBA3C(4), TUBA3D(3), TUBA3E(3), TUBA4A(1), TUBA8(1), TUBAL3(2), TUBB(2), TUBB1(4), TUBB2B(3), TUBB3(2), TUBB6(2), TUBB8(5), WAS(6), WASL(4), YWHAZ(3) 69304726 151 101 147 55 28 48 23 29 23 0 0.947 1.000 1.000 421 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 36 AKT1(2), AKT2(5), AKT3(4), BAD(1), BCR(3), BLNK(1), BTK(7), CD19(6), DAG1(2), EPHB2(5), ITPKA(1), ITPKB(8), LYN(6), MAP2K1(5), MAP2K2(2), MAPK1(1), NFAT5(7), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), PI3(1), PIK3CD(6), PLCG2(8), PPP1R13B(4), RAF1(4), SERPINA4(4), SHC1(2), SOS1(5), SOS2(6), SYK(4), VAV1(6) 66822342 133 101 133 33 26 35 19 31 22 0 0.216 1.000 1.000 422 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(5), F12(2), F13B(5), F2(2), F5(26), F7(2), F8(20), F9(1), FGA(7), FGB(1), FGG(7), LPA(16), PLAT(6), PLAU(4), PLG(7), SERPINB2(1), SERPINE1(5), SERPINF2(2), VWF(11) 49965990 130 100 128 36 19 25 37 27 22 0 0.479 1.000 1.000 423 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(1), ADH1C(4), ADH4(1), ADH6(2), ADH7(3), ADHFE1(2), AGPAT1(1), AGPAT3(2), AGPAT4(2), AKR1A1(1), AKR1B1(3), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), CEL(4), DGAT1(2), DGKA(2), DGKB(5), DGKD(10), DGKE(4), DGKG(8), DGKH(4), DGKQ(2), DGKZ(1), GK(6), GLA(5), GLB1(4), LCT(17), LIPC(2), LIPF(1), LIPG(3), LPL(1), PNLIP(5), PNLIPRP1(4), PNLIPRP2(1), PPAP2A(2), PPAP2C(1) 68462312 138 100 136 39 30 25 30 24 29 0 0.369 1.000 1.000 424 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(3), AGPAT1(1), AGPAT3(2), AGPAT4(2), AGPS(1), CDS1(3), CDS2(3), CHAT(2), CHKA(1), CHKB(5), CLC(1), CPT1B(4), DGKA(2), DGKB(5), DGKD(10), DGKE(4), DGKG(8), DGKH(4), DGKQ(2), DGKZ(1), ETNK1(4), GNPAT(5), GPD1(6), GPD2(3), LCAT(1), LGALS13(3), PAFAH1B1(3), PCYT1A(2), PCYT1B(6), PEMT(1), PISD(1), PLA2G1B(1), PLA2G2A(1), PLA2G2E(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLCB2(7), PLCG1(8), PLCG2(8), PPAP2A(2), PPAP2C(1) 70080437 139 99 138 39 24 29 21 35 29 1 0.392 1.000 1.000 425 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(3), ACTN1(6), ACTN2(10), ACTN3(7), BCAR1(6), BCR(3), CAPN1(8), CAV1(4), CRKL(1), HRAS(2), ITGA1(6), ITGB1(5), JUN(3), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), MAPK8(2), PPP1R12B(4), PTK2(7), RAF1(4), RAP1A(2), ROCK1(8), SHC1(2), SOS1(5), SRC(1), TLN1(16), VCL(6), ZYX(2) 66653621 132 99 132 46 28 34 17 25 26 2 0.900 1.000 1.000 426 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 40 CHUK(8), DAXX(2), EGF(5), EGFR(5), ETS1(3), ETS2(7), FOS(1), HRAS(2), IKBKB(6), JUN(3), MAP2K1(5), MAP2K3(3), MAP2K6(1), MAP2K7(1), MAP3K5(12), MAPK1(1), MAPK13(1), MAPK14(2), MAPK3(1), MAPK8(2), NFKB1(5), NFKBIA(3), PPP2CA(3), PRKCA(4), PRKCD(5), PRKCE(8), PRKCG(3), PRKCH(3), PRKCQ(9), RAF1(4), RELA(3), RIPK1(5), SP1(6), TNFRSF1A(4), TNFRSF1B(2), TRAF2(1) 63782664 139 97 136 36 30 33 17 30 28 1 0.390 1.000 1.000 427 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(2), ACTR3(2), ARHGAP1(4), ARHGAP4(6), ARHGAP5(12), ARHGAP6(5), ARHGEF1(10), ARHGEF11(6), ARHGEF5(10), ARPC1A(3), ARPC1B(2), ARPC2(5), BAIAP2(2), CFL1(1), DIAPH1(5), GSN(2), LIMK1(8), MYLK(11), OPHN1(4), PIP5K1A(6), PIP5K1B(2), PPP1R12B(4), ROCK1(8), SRC(1), TLN1(16), VCL(6) 65837122 143 97 140 50 22 33 25 23 40 0 0.946 1.000 1.000 428 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 39 AKT1(2), ASAH1(1), ATF1(3), BRAF(5), CREB1(2), CREB3(1), CREB5(4), CREBBP(15), CRKL(1), DAG1(2), EGR1(3), EGR2(3), EGR3(4), ELK1(4), FRS2(1), GNAQ(1), JUN(3), MAP1B(8), MAP2K7(1), MAPK1(1), MAPK10(4), MAPK3(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(8), MAPK9(1), NTRK1(8), OPN1LW(3), PIK3C2G(8), PIK3CD(6), PTPN11(1), RPS6KA3(8), SHC1(2), SRC(1), TERF2IP(3), TH(2) 65038342 126 97 124 34 33 27 17 24 25 0 0.419 1.000 1.000 429 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(9), AARS2(5), CARS(5), CARS2(5), DARS(4), DARS2(2), EARS2(3), EPRS(11), FARS2(4), FARSA(3), FARSB(5), GARS(2), HARS(1), IARS(8), IARS2(5), LARS(5), LARS2(3), MARS(11), MARS2(1), NARS(1), NARS2(2), PARS2(2), QARS(10), RARS(5), RARS2(3), SARS(4), TARS(8), TARS2(11), VARS(2), VARS2(1), WARS2(2), YARS(4), YARS2(1) 74308153 148 96 146 36 19 54 20 31 24 0 0.278 1.000 1.000 430 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 39 ALK(8), AR(6), ESR1(7), ESR2(5), HNF4A(2), NR1D1(5), NR1D2(2), NR1H2(7), NR1H3(2), NR1I2(2), NR1I3(2), NR2C2(2), NR2E1(3), NR2F1(1), NR2F2(1), NR3C1(3), NR4A1(3), NR4A2(3), NR5A1(1), NR5A2(7), PGR(6), PPARA(4), PPARD(2), PPARG(5), RARA(1), RARB(6), RARG(3), ROR1(9), RORA(1), RORC(2), RXRA(2), RXRG(2), THRA(3), THRB(2) 56476040 120 96 119 42 29 19 22 21 29 0 0.864 1.000 1.000 431 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 33 ACTG2(4), ACTR2(2), ACTR3(2), AKT1(2), ANGPTL2(1), CFL1(1), CFL2(1), FLNA(20), FLNC(21), FSCN1(1), FSCN3(1), GDI1(3), GDI2(2), LIMK1(8), MYH2(9), MYLK(11), MYLK2(5), PAK1(4), PAK2(2), PAK3(5), PAK4(3), PAK6(5), PAK7(4), RHO(2), ROCK1(8), ROCK2(9), RPS4X(2), WASF1(6), WASL(4) 64389761 148 96 147 49 32 31 28 30 26 1 0.824 1.000 1.000 432 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(3), AKR1B10(1), B4GALT1(3), G6PC(2), G6PC2(3), GAA(2), GALE(1), GALK2(4), GALT(2), GANC(4), GCK(3), GLA(5), GLB1(4), HK1(3), HK2(5), HK3(5), HSD3B7(1), LALBA(1), LCT(17), MGAM(22), PFKL(1), PFKM(8), PFKP(7), PGM1(5), PGM3(2), RDH11(4), RDH12(2), RDH13(2), RDH14(2), UGP2(4) 54171946 128 95 125 35 15 27 27 41 18 0 0.319 1.000 1.000 433 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(1), ACAA2(2), ACADL(1), ACADS(2), ACADSB(4), ACADVL(5), ACAT1(3), ACOX1(4), ACOX3(5), ACSL1(3), ACSL3(3), ACSL4(5), ACSL5(5), ACSL6(4), ADH1A(1), ADH1C(4), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), CPT1A(6), CPT1B(4), CPT1C(7), CPT2(5), CYP4A11(8), CYP4A22(2), EHHADH(4), GCDH(2), HADH(2), HADHA(3), HADHB(3), HSD17B10(1), HSD17B4(8) 70206659 137 95 136 33 25 35 34 28 14 1 0.139 1.000 1.000 434 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 45 AKT1(2), AKT2(5), AKT3(4), BRD4(3), CAP1(3), CBL(4), CDKN2A(1), F2RL2(2), FLOT1(2), FLOT2(3), GSK3A(5), GSK3B(2), INPPL1(6), IRS1(4), IRS4(7), LNPEP(2), MAPK1(1), MAPK3(1), PARD3(8), PARD6A(1), PDK1(2), PIK3CD(6), PPYR1(4), RAF1(4), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), RPS6KB1(4), SERPINB6(3), SFN(1), SHC1(2), SLC2A4(3), SORBS1(7), SOS1(5), SOS2(6), YWHAB(2), YWHAG(1), YWHAZ(3) 73529147 139 95 138 41 27 41 13 29 28 1 0.652 1.000 1.000 435 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(6), AKT1(2), AKT2(5), AKT3(4), DAG1(2), GNAQ(1), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), PDK1(2), PHKA2(13), PIK3CB(8), PITX2(5), PLD1(7), PLD2(2), PLD3(2), VN1R1(1) 63170641 133 95 132 34 22 39 14 36 22 0 0.228 1.000 1.000 436 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 30 ACTR2(2), ACTR3(2), AKT1(2), ANGPTL2(1), DAG1(2), DGKA(2), ETFA(1), ITGA9(7), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), MAP2K1(5), MAPK1(1), MAPK3(1), NR1I3(2), PAK1(4), PDE3A(12), PDE3B(4), PI3(1), PIK3C2G(8), PIK3CD(6), PSME1(1), RIPK3(4), RPS4X(2), SGCB(2) 64828554 128 94 126 40 19 39 14 36 20 0 0.703 1.000 1.000 437 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 38 CALM2(2), CD3E(3), CD3G(3), ELK1(4), FOS(1), HRAS(2), JUN(3), LAT(1), LCK(2), MAP2K1(5), MAPK3(1), MAPK8(2), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), NFKB1(5), NFKBIA(3), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(1), PRKCA(4), PTPN7(5), RAF1(4), RASA1(2), RELA(3), SHC1(2), SOS1(5), SYT1(2), VAV1(6), ZAP70(3) 56384859 116 93 116 36 23 29 18 25 21 0 0.638 1.000 1.000 438 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ABP1(1), ACAT1(3), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), AOC2(6), AOC3(3), AOX1(7), ASMT(1), CAT(2), CYP1A1(1), CYP1A2(2), CYP2A13(8), CYP2A6(1), CYP2A7(1), CYP2B6(5), CYP2C18(2), CYP2C19(6), CYP2C8(3), CYP2C9(3), CYP2D6(3), CYP2E1(2), CYP2F1(5), CYP3A4(4), CYP3A5(2), CYP3A7(5), CYP4B1(4), CYP4F8(1), CYP51A1(2), DDC(4), EHHADH(4), GCDH(2), HAAO(2), HADHA(3), KMO(8), KYNU(3), MAOA(2), MAOB(4), TDO2(2), TPH1(3), WARS2(2) 78967109 145 93 144 54 18 40 26 37 23 1 0.927 1.000 1.000 439 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 33 BTK(7), CALM2(2), ELK1(4), FCER1A(4), FOS(1), HRAS(2), JUN(3), LYN(6), MAP2K1(5), MAP2K7(1), MAPK1(1), MAPK3(1), MAPK8(2), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), PAK2(2), PLA2G4A(7), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(1), RAF1(4), SHC1(2), SOS1(5), SYK(4), SYT1(2), VAV1(6) 49282400 114 91 114 27 21 31 19 27 16 0 0.186 1.000 1.000 440 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(4), CDC7(2), CDK2(2), CDT1(2), DIAPH2(9), GMNN(2), MCM10(7), MCM2(5), MCM3(4), MCM4(5), MCM5(3), MCM6(4), MCM7(7), NACA(8), POLA2(6), POLD1(5), POLD2(1), POLE(10), POLE2(2), PRIM1(1), RFC1(7), RFC2(1), RFC4(3), RFC5(1), RPA1(1), RPA2(2), RPA3(2), RPA4(3), UBA52(2), UBC(13) 72199391 124 90 123 35 15 40 19 27 22 1 0.752 1.000 1.000 441 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(5), CALM2(2), CREB1(2), ELK1(4), FOS(1), GNAI1(2), GNAQ(1), GNAS(11), GNB1(2), HRAS(2), JUN(3), MAP2K1(5), MAPK3(1), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(1), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKCA(4), RAF1(4), RPS6KA3(8), SYT1(2) 47297656 117 90 117 32 27 27 19 23 21 0 0.422 1.000 1.000 442 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 32 AKT1(2), AKT2(5), AKT3(4), ARHGEF11(6), DLG4(1), GNA13(1), LPA(16), MAP3K5(12), MAPK8(2), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), PDK1(2), PHKA2(13), PI3(1), PIK3CB(8), PLD1(7), PLD2(2), PLD3(2), PTK2(7), RDX(3), ROCK1(8), ROCK2(9), SERPINA4(4), SRF(1) 64294127 133 90 132 37 29 38 17 21 28 0 0.471 1.000 1.000 443 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(2), AKT2(5), AKT3(4), ANKRD6(5), APC(23), AXIN1(5), AXIN2(5), CER1(2), CSNK1A1(4), CTNNB1(2), DACT1(2), DKK2(1), DKK3(4), DKK4(3), DVL1(2), FSTL1(1), GSK3A(5), GSK3B(2), LRP1(28), MVP(2), NKD1(1), NKD2(2), PSEN1(2), PTPRA(6), SENP2(1), SFRP1(3), WIF1(3) 56778961 125 89 125 38 25 32 17 26 22 3 0.760 1.000 1.000 444 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(7), ACAA1(1), ACAA2(2), ACADS(2), ACAT1(3), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH6A1(1), ALDH9A1(1), AOX1(7), AUH(1), BCAT1(4), BCAT2(5), BCKDHA(4), BCKDHB(1), DBT(1), DLD(1), EHHADH(4), HADH(2), HADHA(3), HADHB(3), HIBADH(2), HIBCH(2), HMGCS1(6), HMGCS2(3), HSD17B10(1), HSD17B4(8), IVD(3), MCCC1(4), MCCC2(1), MUT(3), OXCT1(5), OXCT2(5), PCCA(4), PCCB(2) 62197409 118 88 115 27 21 34 19 24 20 0 0.193 1.000 1.000 445 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(2), ALG10(3), ALG10B(6), ALG11(1), ALG12(3), ALG13(5), ALG14(1), ALG2(2), ALG3(1), ALG5(5), ALG6(2), ALG8(2), ALG9(2), B4GALT1(3), B4GALT3(2), DAD1(1), DDOST(2), DHDDS(5), DOLPP1(2), DPAGT1(4), DPM1(4), FUT8(2), GANAB(10), MAN1A1(6), MAN1A2(3), MAN1B1(3), MAN2A1(6), MGAT3(4), MGAT4A(4), MGAT4B(5), MGAT5(3), MGAT5B(8), RPN1(4), RPN2(2), ST6GAL1(3), STT3B(3) 59247143 124 87 124 30 13 34 34 25 17 1 0.243 1.000 1.000 446 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(2), APC(23), ASAH1(1), DAG1(2), DLG4(1), EPHB2(5), GNAI1(2), GNAQ(1), ITPR1(15), ITPR2(18), ITPR3(14), KCNJ3(2), KCNJ5(1), KCNJ9(1), MAPK1(1), PITX2(5), PTX3(1), RHO(2), RYR1(29) 65501142 126 87 125 47 27 28 16 40 14 1 0.918 1.000 1.000 447 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 33 BLNK(1), BTK(7), CALM2(2), CD79B(2), ELK1(4), FOS(1), HRAS(2), JUN(3), LYN(6), MAP2K1(5), MAPK14(2), MAPK3(1), MAPK8(2), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(1), PRKCA(4), RAF1(4), SHC1(2), SOS1(5), SYK(4), SYT1(2), VAV1(6) 49219771 108 86 108 33 19 27 19 28 15 0 0.630 1.000 1.000 448 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(1), AGXT(1), AGXT2(2), AKR1B10(1), ALAS1(6), ALAS2(8), AMT(1), AOC2(6), AOC3(3), BHMT(1), CBS(1), CHKA(1), CHKB(5), CTH(3), DAO(1), DLD(1), DMGDH(7), GAMT(1), GARS(2), GATM(3), GCAT(4), GLDC(8), HSD3B7(1), MAOA(2), MAOB(4), PEMT(1), PHGDH(1), PIPOX(2), PISD(1), PSAT1(1), PSPH(1), RDH11(4), RDH12(2), RDH13(2), RDH14(2), SARDH(4), SARS(4), SHMT1(1), SHMT2(4), TARS(8), TARS2(11) 61019753 123 86 123 38 14 29 23 37 20 0 0.572 1.000 1.000 449 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(1), AGMAT(4), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH4A1(3), ALDH9A1(1), AMD1(2), AOC2(6), AOC3(3), ARG1(3), ARG2(2), ASL(4), CKB(1), CKM(1), CKMT1A(1), CKMT1B(1), CKMT2(5), CPS1(12), DAO(1), GAMT(1), GATM(3), GLUD1(2), GOT1(2), GOT2(1), MAOA(2), MAOB(4), NOS1(13), NOS3(3), OAT(2), OTC(3), P4HA1(3), P4HA2(5), P4HA3(4), P4HB(2), PYCR1(1), RARS(5) 62223883 128 85 127 38 24 31 39 21 13 0 0.435 1.000 1.000 450 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(3), AGTR2(2), CALM2(2), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CDK5(2), F2(2), GNA11(4), GNAI1(2), GNB1(2), HRAS(2), JAK2(7), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK14(2), MAPK3(1), MAPK8(2), MAPT(4), MYLK(11), PLCG1(8), PRKCA(4), PTK2B(7), RAF1(4), SHC1(2), SOS1(5), STAT1(4), STAT3(5), STAT5A(6), SYT1(2) 59850132 116 85 116 34 21 31 18 25 21 0 0.525 1.000 1.000 451 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(1), AGXT(1), AGXT2(2), ALAS1(6), ALAS2(8), AMT(1), AOC2(6), AOC3(3), ATP6V0C(1), BHMT(1), CBS(1), CHKA(1), CHKB(5), CPT1B(4), CTH(3), DAO(1), DLD(1), DMGDH(7), GAMT(1), GARS(2), GATM(3), GCAT(4), GLDC(8), MAOA(2), MAOB(4), PEMT(1), PISD(1), PLCB2(7), PLCG1(8), PLCG2(8), PSPH(1), SARDH(4), SARS(4), SHMT1(1), SHMT2(4), TARS(8) 59848972 124 85 124 45 19 23 22 34 25 1 0.892 1.000 1.000 452 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 28 ARSB(3), FUCA1(1), FUCA2(3), GALNS(2), GBA(2), GLB1(4), GNS(3), GUSB(6), HEXA(3), HEXB(3), HGSNAT(6), HPSE(6), HPSE2(5), HYAL2(3), IDS(3), IDUA(1), LCT(17), MAN2B1(6), MAN2B2(9), MAN2C1(6), MANBA(5), NAGLU(2), NEU1(1), NEU3(2), SPAM1(4) 46796057 106 85 107 30 20 31 16 22 17 0 0.420 1.000 1.000 453 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 32 ACTA1(3), CRK(1), CRKL(1), DOCK1(8), ELK1(4), FOS(1), GAB1(2), HGF(5), HRAS(2), ITGA1(6), ITGB1(5), JUN(3), MAP2K1(5), MAP2K2(2), MAP4K1(10), MAPK1(1), MAPK3(1), MAPK8(2), MET(10), PAK1(4), PTK2(7), PTK2B(7), PTPN11(1), RAF1(4), RAP1A(2), RAP1B(1), RASA1(2), SOS1(5), SRC(1), STAT3(5) 58628891 111 85 111 30 26 31 19 18 16 1 0.419 1.000 1.000 454 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(3), B4GALT1(3), G6PC(2), GAA(2), GALE(1), GALK2(4), GALT(2), GANAB(10), GCK(3), GLA(5), GLB1(4), HK1(3), HK2(5), HK3(5), LALBA(1), LCT(17), MGAM(22), PFKM(8), PFKP(7), PGM1(5), PGM3(2) 45975652 114 84 111 32 15 23 27 34 15 0 0.386 1.000 1.000 455 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 58 A4GALT(1), B3GALNT1(2), B3GALT1(3), B3GALT2(2), B3GALT4(2), B3GALT5(2), B3GNT1(1), B3GNT2(2), B3GNT3(1), B3GNT4(1), B3GNT5(4), B4GALNT1(1), B4GALT1(3), B4GALT3(2), B4GALT4(2), B4GALT6(2), FUT1(1), FUT3(3), FUT5(2), FUT6(3), GBGT1(2), GCNT2(1), PIGA(5), PIGB(2), PIGG(7), PIGL(2), PIGM(3), PIGN(4), PIGO(3), PIGQ(4), PIGS(2), PIGT(5), PIGV(2), PIGZ(3), ST3GAL1(2), ST3GAL2(2), ST3GAL3(5), ST3GAL4(2), ST3GAL5(2), ST3GAL6(1), ST6GALNAC3(4), ST6GALNAC4(1), ST6GALNAC5(2), ST6GALNAC6(4), ST8SIA1(1), UGCG(1) 66934964 112 83 112 29 18 28 28 22 16 0 0.198 1.000 1.000 456 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS1(6), ALAS2(8), BLVRA(4), BLVRB(1), COX10(7), COX15(3), CP(8), EARS2(3), EPRS(11), FTMT(2), GUSB(6), HCCS(1), HMBS(3), HMOX2(1), MMAB(1), PPOX(6), UGT1A1(4), UGT1A10(3), UGT1A3(3), UGT1A4(4), UGT1A6(2), UGT1A7(3), UGT1A8(2), UGT1A9(2), UGT2A1(7), UGT2B10(3), UGT2B11(1), UGT2B15(5), UGT2B17(2), UGT2B28(3), UGT2B4(3), UGT2B7(3), UROD(2), UROS(2) 59732475 125 82 124 42 9 36 24 38 17 1 0.884 1.000 1.000 457 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), DAG1(2), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), NFAT5(7), PDE6A(7), PDE6B(3), PDE6C(6), SLC6A13(4), TF(5) 51432746 103 82 102 36 14 31 14 30 14 0 0.844 1.000 1.000 458 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 41 ACACA(13), ACACB(13), ACAT1(3), ACOT12(1), ACSS1(1), ACSS2(2), ACYP1(2), AKR1B1(3), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), DLAT(2), DLD(1), GRHPR(3), HAGH(1), LDHA(3), LDHC(4), LDHD(1), MDH1(1), ME2(2), ME3(4), PC(10), PCK1(5), PCK2(4), PDHA1(2), PDHA2(4), PDHB(1), PKLR(5) 65943923 108 81 107 30 25 28 21 21 13 0 0.313 1.000 1.000 459 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(3), CAPN1(8), CAPN2(8), CXCR3(6), EGF(5), EGFR(5), HRAS(2), ITGA1(6), ITGB1(5), MAPK1(1), MAPK3(1), MYLK(11), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PTK2(7), TLN1(16) 47753526 99 79 98 32 20 22 22 19 15 1 0.666 1.000 1.000 460 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 37 ANAPC1(11), ANAPC10(1), ANAPC11(1), ANAPC4(4), ANAPC5(5), ANAPC7(5), BTRC(4), CDC16(3), CDC20(1), CDC23(2), CUL1(2), CUL2(4), CUL3(5), ITCH(4), SKP1(1), SKP2(2), SMURF1(3), SMURF2(5), TCEB1(1), UBA1(8), UBE2C(1), UBE2D1(1), UBE2D2(3), UBE2D3(2), UBE2E1(1), UBE2E3(1), WWP1(6), WWP2(12) 53352598 99 78 96 22 14 37 15 19 13 1 0.297 1.000 1.000 461 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDH(6), AASDHPPT(4), AASS(5), ACAT1(3), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), ATP6V0C(1), BBOX1(2), DLST(3), DOT1L(10), EHHADH(4), EHMT1(9), EHMT2(6), GCDH(2), HADHA(3), PLOD1(2), PLOD2(2), PLOD3(9), SHMT1(1), SHMT2(4), TMLHE(1) 49117614 99 78 97 33 12 21 28 18 20 0 0.833 1.000 1.000 462 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 40 ACTG2(4), ADCY3(5), ADCY9(14), AK1(1), ARF1(2), ATP6V0A1(6), ATP6V0A2(3), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V0D2(2), ATP6V0E1(2), ATP6V1A(4), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1E2(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), ERO1L(3), GNAS(11), PDIA4(7), PLCG1(8), PLCG2(8), PRKCA(4), SEC61A1(4), SEC61A2(4), TRIM23(4) 51931959 116 77 115 30 22 37 18 18 21 0 0.267 1.000 1.000 463 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(3), ATP4B(3), ATP5O(2), ATP6AP1(2), ATP6V0A1(6), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), ATP7A(13), ATP7B(6), COX10(7), COX5A(1), COX5B(1), COX6A1(1), COX6C(1), COX7A2(2), NDUFA1(2), NDUFA10(1), NDUFA4(1), NDUFB5(4), NDUFB6(2), NDUFS1(1), NDUFS2(7), NDUFV1(5), NDUFV2(1), PPA2(2), SDHB(2), SHMT1(1), UQCRB(1), UQCRC1(1), UQCRFS1(1) 55684794 111 76 111 36 21 35 16 23 16 0 0.706 1.000 1.000 464 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 DPM2(1), EGFR(5), ELK1(4), GNAS(11), GNB1(2), HRAS(2), IGF1R(7), ITGB1(5), KLK2(3), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), MKNK1(2), MKNK2(4), MYC(1), NGFR(1), PDGFRA(6), PPP2CA(3), PTPRR(4), RAF1(4), RPS6KA1(7), RPS6KA5(4), SHC1(2), SOS1(5), SRC(1), STAT3(5) 46574076 98 75 96 25 20 26 12 27 13 0 0.378 1.000 1.000 465 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 35 ARSA(2), ARSE(4), ASAH1(1), B4GALT6(2), CERK(2), DEGS1(4), DEGS2(1), ENPP7(5), GAL3ST1(5), GALC(1), GBA(2), GLA(5), GLB1(4), LCT(17), NEU1(1), NEU3(2), PPAP2A(2), PPAP2C(1), SGMS1(2), SGMS2(2), SGPP1(2), SGPP2(1), SMPD1(2), SMPD2(2), SMPD3(1), SMPD4(4), SPHK1(1), SPHK2(3), SPTLC1(4), SPTLC2(6), UGCG(1), UGT8(5) 47091390 97 75 95 26 20 28 15 23 11 0 0.304 1.000 1.000 466 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B4GALT5(4), C1GALT1(3), C1GALT1C1(3), GALNT1(3), GALNT10(5), GALNT11(5), GALNT12(2), GALNT13(6), GALNT14(1), GALNT2(2), GALNT3(3), GALNT4(1), GALNT5(6), GALNT6(3), GALNT7(5), GALNT8(6), GALNT9(6), GALNTL1(3), GALNTL2(2), GALNTL4(1), GALNTL5(7), GCNT3(1), GCNT4(3), OGT(5), ST3GAL1(2), ST3GAL2(2), ST6GALNAC1(6), WBSCR17(7) 46701401 103 73 103 38 18 24 16 28 14 3 0.921 1.000 1.000 467 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 APC(23), ATF2(4), AXIN1(5), BMP10(1), BMP2(3), BMP4(2), BMP5(4), BMPR1A(1), BMPR2(8), CHRD(5), CTNNB1(2), DVL1(2), FZD1(3), GATA4(2), GSK3B(2), MAP3K7(3), MEF2C(4), NKX2-5(1), NOG(1), NPPA(1), RFC1(7), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TGFBR2(4), TGFBR3(4) 50555577 100 72 99 32 14 26 13 29 16 2 0.838 1.000 1.000 468 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(3), AKR1B10(1), ALDOA(5), ALDOB(3), ALDOC(2), FBP1(2), FPGT(1), FUK(4), GMDS(2), GMPPA(1), HK1(3), HK2(5), HK3(5), HSD3B7(1), KHK(4), MPI(2), MTMR1(1), MTMR2(2), MTMR6(3), PFKFB2(1), PFKFB3(4), PFKFB4(3), PFKL(1), PFKM(8), PFKP(7), PGM2(5), PMM1(2), RDH11(4), RDH12(2), RDH13(2), RDH14(2), SORD(2), TPI1(2), TSTA3(2) 53022759 97 71 95 27 15 20 14 29 19 0 0.431 1.000 1.000 469 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(5), ADRBK2(1), ARRB2(1), CALM2(2), CALML6(1), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CLCA1(6), CLCA2(5), CLCA4(4), CNGA3(4), CNGA4(5), CNGB1(4), GUCA1A(1), GUCA1B(1), GUCA1C(4), PDC(1), PDE1C(5), PRKACA(4), PRKACB(1), PRKACG(3), PRKG1(5), PRKG2(8), PRKX(5) 44104497 89 70 88 42 13 21 16 25 14 0 0.996 1.000 1.000 470 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 36 ACACA(13), ACAT1(3), ACYP1(2), ADH5(5), AKR1B1(3), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), DLAT(2), DLD(1), GRHPR(3), HAGH(1), LDHA(3), LDHC(4), LDHD(1), MDH1(1), ME2(2), ME3(4), PC(10), PCK1(5), PDHA1(2), PDHA2(4), PDHB(1), PKLR(5) 51950911 97 70 96 27 21 28 19 16 13 0 0.369 1.000 1.000 471 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(3), BAD(1), BRAF(5), CREB1(2), CREB3(1), CREB5(4), DUSP4(1), DUSP6(1), DUSP9(2), EEF2K(6), MAP2K1(5), MAP2K2(2), MAP3K8(4), MAPK1(1), MAPK3(1), MKNK1(2), MKNK2(4), MOS(3), NFKB1(5), RAP1A(2), RPS6KA1(7), RPS6KA2(5), RPS6KA3(8), SHC1(2), SOS1(5), SOS2(6), TRAF3(3) 42224949 91 70 90 23 17 22 10 20 21 1 0.380 1.000 1.000 472 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 34 AKT1(2), ATF1(3), CREB1(2), CREB3(1), CREB5(4), DUSP1(1), DUSP10(9), EEF2K(6), ELK1(4), IL1R1(1), MAP2K3(3), MAP2K6(1), MAP3K10(3), MAP3K4(8), MAP3K5(12), MAP3K7(3), MAPK1(1), MAPK13(1), MAPK14(2), MAPKAPK2(1), MKNK1(2), MKNK2(4), MYEF2(3), NFKB1(5), NR2C2(2), SRF(1), TRAF6(4) 46173423 89 70 87 37 15 21 14 22 17 0 0.979 1.000 1.000 473 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(3), ACTN1(6), ACTN2(10), ACTN3(7), CAPN1(8), ITGA1(6), ITGB1(5), ITGB3(4), PTK2(7), SPTAN1(13), SRC(1), TLN1(16) 41376609 86 70 86 30 19 20 15 17 14 1 0.873 1.000 1.000 474 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 38 ARNTL(2), AZIN1(3), CBX3(2), CLOCK(3), CRY1(2), CRY2(3), DNAJA1(2), EIF4G2(2), ETV6(4), GSTP1(1), HSPA8(6), IDI1(7), MYF6(5), NCKAP1(9), NR1D2(2), PER1(10), PER2(8), PPP1R3C(3), PPP2CB(2), SF3A3(1), TOB1(2), TUBB3(2), UCP3(2), UGP2(4), VAPA(2), ZFR(7) 51576361 96 69 96 32 14 39 15 15 12 1 0.917 1.000 1.000 475 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 37 ACAA1(1), ACAA2(2), ACAD8(1), ACAD9(4), ADH1A(1), ADH1C(4), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), AKR1B10(1), AKR1C4(3), AKR1D1(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), BAAT(5), CEL(4), CYP27A1(1), CYP7A1(3), HADHB(3), HSD3B7(1), LIPA(4), RDH11(4), RDH12(2), RDH13(2), RDH14(2), SLC27A5(4), SOAT1(2), SOAT2(2), SRD5A1(4) 44785865 91 68 90 25 16 17 26 16 16 0 0.351 1.000 1.000 476 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 23 POLA1(15), POLA2(6), POLB(1), POLD1(5), POLD2(1), POLE(10), POLE2(2), POLE3(1), POLG(7), POLG2(2), POLH(3), POLI(2), POLK(2), POLL(3), POLM(4), POLQ(12), PRIM1(1), REV1(6), REV3L(17), RFC5(1) 58314418 101 68 99 24 10 25 22 25 18 1 0.457 1.000 1.000 477 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM2(2), DLG4(1), GRIN1(3), GRIN2A(16), GRIN2B(11), GRIN2C(5), GRIN2D(5), NOS1(13), PPP3CA(5), PPP3CB(3), PPP3CC(1), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKCA(4), SYT1(2) 36099627 86 68 86 31 18 20 21 15 12 0 0.711 1.000 1.000 478 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 20 ARHGAP5(12), DIAPH1(5), GSN(2), HRAS(2), ITGA1(6), ITGB1(5), MAP2K1(5), MAPK1(1), MAPK3(1), MYLK(11), PTK2(7), RAF1(4), ROCK1(8), SHC1(2), SRC(1), TLN1(16) 49041900 88 67 88 27 14 24 15 17 18 0 0.720 1.000 1.000 479 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(7), ACACA(13), ACACB(13), ACAT1(3), ACSS1(1), ACSS2(2), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH6A1(1), ALDH9A1(1), EHHADH(4), HADHA(3), HIBCH(2), LDHA(3), LDHC(4), MLYCD(4), MUT(3), PCCA(4), PCCB(2), SUCLA2(1), SUCLG2(1) 57129081 88 67 87 28 9 28 18 20 13 0 0.695 1.000 1.000 480 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(2), AP2A1(6), AP2M1(4), ARF1(2), BAD(1), BTK(7), EEA1(10), GRASP(2), GSK3A(5), GSK3B(2), LYN(6), PDPK1(2), PFKL(1), PFKM(8), PFKP(7), PLCG1(8), PRKCE(8), PRKCZ(2), RPS6KB1(4), VAV2(3) 35572963 90 67 88 32 17 19 14 23 17 0 0.902 1.000 1.000 481 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 22 CSNK2A1(3), EGF(5), EGFR(5), ELK1(4), FOS(1), HRAS(2), JAK1(11), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(2), PLCG1(8), PRKCA(4), RAF1(4), RASA1(2), SHC1(2), SOS1(5), SRF(1), STAT1(4), STAT3(5), STAT5A(6) 43202467 83 66 82 23 15 17 11 22 18 0 0.540 1.000 1.000 482 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(23), AXIN1(5), CREBBP(15), CTNNB1(2), DVL1(2), EP300(13), FZD1(3), GSK3B(2), HDAC1(5), LDB1(1), PITX2(5), TRRAP(18) 46527569 94 66 94 28 15 19 13 28 17 2 0.720 1.000 1.000 483 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 31 AGT(3), AGTR1(4), ATF2(4), CALM2(2), EGFR(5), ELK1(4), GNAQ(1), HRAS(2), JUN(3), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), MAPK8(2), MEF2A(6), MEF2C(4), MEF2D(3), PAK1(4), PRKCA(4), PTK2(7), PTK2B(7), RAF1(4), SHC1(2), SOS1(5), SRC(1), SYT1(2) 43968525 88 65 87 22 16 27 12 20 13 0 0.277 1.000 1.000 484 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 19 ARFIP2(5), CDK5(2), CDK5R1(1), CFL1(1), CHN1(4), LIMK1(8), MYLK(11), NCF2(7), PAK1(4), PDGFRA(6), PLD1(7), PPP1R12B(4), RALBP1(3), RPS6KB1(4), TRIO(13), VAV1(6), WASF1(6) 41206082 92 65 91 30 10 26 23 18 15 0 0.765 1.000 1.000 485 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(9), CARS(5), DARS(4), EPRS(11), FARS2(4), GARS(2), HARS(1), IARS(8), LARS(5), LARS2(3), MARS(11), MARS2(1), NARS(1), QARS(10), RARS(5), SARS(4), TARS(8), WARS2(2), YARS(4) 46204518 98 64 97 24 11 35 14 23 15 0 0.306 1.000 1.000 486 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 20 ADCY1(5), CD3E(3), CD3G(3), CD4(4), CREBBP(15), GNAS(11), GNB1(2), HLA-DRB1(10), LCK(2), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PTPRC(8), ZAP70(3) 30931583 81 64 81 27 16 17 17 14 17 0 0.787 1.000 1.000 487 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 20 ADCY1(5), CD3E(3), CD3G(3), CD4(4), CREBBP(15), GNAS(11), GNB1(2), HLA-DRB1(10), LCK(2), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PTPRC(8), ZAP70(3) 30931583 81 64 81 27 16 17 17 14 17 0 0.787 1.000 1.000 488 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 24 AKT1(2), APC(23), AXIN1(5), CCND1(1), CD14(1), CTNNB1(2), DVL1(2), FZD1(3), GJA1(4), GNAI1(2), GSK3B(2), IRAK1(5), LBP(1), MYD88(1), NFKB1(5), PDPK1(2), PPP2CA(3), RELA(3), TIRAP(1), TLR4(15) 36384978 83 64 82 28 11 25 10 25 10 2 0.888 1.000 1.000 489 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 36 ATF2(4), CREB1(2), DAXX(2), ELK1(4), HMGN1(1), HRAS(2), MAP2K6(1), MAP3K5(12), MAP3K7(3), MAP3K9(6), MAPK14(2), MAPKAPK2(1), MAX(2), MEF2A(6), MEF2C(4), MEF2D(3), MKNK1(2), MYC(1), PLA2G4A(7), RIPK1(5), RPS6KA5(4), SHC1(2), STAT1(4), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TRAF2(1) 47613838 89 64 88 23 16 29 10 22 12 0 0.378 1.000 1.000 490 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(23), AXIN1(5), BTRC(4), CCND1(1), CREBBP(15), CSNK1A1(4), CSNK2A1(3), CTBP1(1), CTNNB1(2), DVL1(2), FZD1(3), GSK3B(2), HDAC1(5), MAP3K7(3), MYC(1), NLK(1), PPARD(2), PPP2CA(3), TLE1(4), WIF1(3) 41357440 87 63 87 27 18 25 10 19 13 2 0.806 1.000 1.000 491 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 24 ADCY1(5), AKT1(2), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CREB1(2), GNAS(11), HRAS(2), MAPK1(1), MAPK14(2), MAPK3(1), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), PRKCA(4), RPS6KA1(7), RPS6KA5(4), SOS1(5) 35263639 74 62 73 22 17 15 13 13 16 0 0.727 1.000 1.000 492 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 30 CHUK(8), IFNA1(1), IKBKB(6), IL1A(1), IL1R1(1), IL1RAP(10), IL1RN(2), IL6(2), IRAK1(5), IRAK2(4), IRAK3(2), JUN(3), MAP2K3(3), MAP2K6(1), MAP3K7(3), MAPK14(2), MAPK8(2), MYD88(1), NFKB1(5), NFKBIA(3), RELA(3), TGFB1(2), TGFB2(1), TGFB3(1), TRAF6(4) 38316332 76 62 76 19 14 20 14 11 17 0 0.411 1.000 1.000 493 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 22 CSNK2A1(3), ELK1(4), FOS(1), HRAS(2), JAK1(11), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(2), PDGFRA(6), PLCG1(8), PRKCA(4), RAF1(4), RASA1(2), SHC1(2), SOS1(5), SRF(1), STAT1(4), STAT3(5), STAT5A(6) 39513993 79 62 79 20 15 20 9 18 17 0 0.359 1.000 1.000 494 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(1), ACAA2(2), ACADL(1), ACADS(2), ACADSB(4), ACAT1(3), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH6A1(1), ALDH9A1(1), AOX1(7), BCAT1(4), BCKDHA(4), BCKDHB(1), EHHADH(4), HADHA(3), HADHB(3), HIBADH(2), IVD(3), MCCC1(4), MCCC2(1), MUT(3), OXCT1(5), PCCA(4), PCCB(2) 51861515 86 62 85 22 14 22 15 19 16 0 0.413 1.000 1.000 495 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 28 AKR1C4(3), AKR1D1(1), ARSB(3), ARSE(4), CYP11B1(5), CYP11B2(4), HSD11B1(3), HSD11B2(2), HSD17B2(4), HSD17B3(2), HSD3B1(3), HSD3B2(4), SRD5A1(4), STS(1), SULT1E1(4), UGT1A1(4), UGT1A10(3), UGT1A3(3), UGT1A4(4), UGT1A6(2), UGT1A7(3), UGT1A8(2), UGT1A9(2), UGT2B15(5), UGT2B4(3) 38118021 78 60 77 26 8 22 20 20 8 0 0.619 1.000 1.000 496 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(7), ACACA(13), ACADL(1), ACADSB(4), ACAT1(3), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH6A1(1), ALDH9A1(1), EHHADH(4), HADHA(3), LDHA(3), LDHC(4), MLYCD(4), MUT(3), PCCA(4), PCCB(2), SUCLA2(1), SUCLG2(1) 47737000 80 60 79 27 7 28 15 17 13 0 0.829 1.000 1.000 497 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 26 AKT1(2), CABIN1(8), CALM2(2), CAMK1(1), CAMK1G(5), HDAC5(6), IGF1R(7), INSR(11), MAP2K6(1), MAPK14(2), MAPK7(4), MEF2A(6), MEF2C(4), MEF2D(3), NFATC1(5), NFATC2(4), PPP3CA(5), PPP3CB(3), PPP3CC(1), SYT1(2) 42316178 82 59 82 26 7 28 12 23 12 0 0.652 1.000 1.000 498 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(8), C5(5), C6(8), C7(8), ICAM1(2), IL1A(1), IL6(2), IL8(1), ITGA4(6), ITGAL(5), ITGB1(5), ITGB2(8), SELP(11), SELPLG(2), VCAM1(7) 35558244 79 59 79 27 9 22 18 22 8 0 0.805 1.000 1.000 499 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(2), CDK7(3), ERCC3(5), GTF2E1(2), GTF2E2(3), GTF2F2(1), GTF2H1(2), ILK(3), MNAT1(2), POLR1A(10), POLR1B(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2F(5), POLR2G(1), POLR2H(1), POLR2J(1), POLR3B(2), POLR3D(2), POLR3E(4), POLR3H(1), POLR3K(1), TAF13(1), TAF5(4), TAF6(3), TAF7(1), TAF9(2), TBP(2) 49360508 80 59 79 30 10 20 12 18 20 0 0.956 1.000 1.000 500 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(7), ABP1(1), ACADL(1), ACADSB(4), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), AOC2(6), AOC3(3), CNDP1(7), DPYD(2), DPYS(3), EHHADH(4), GAD1(3), GAD2(3), HADHA(3), MLYCD(4), UPB1(3) 41022518 76 58 75 28 10 20 18 15 13 0 0.865 1.000 1.000 501 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP2(2), ACP5(3), ACPP(6), ACPT(1), ALPL(1), ALPP(3), ALPPL2(2), CYP1A1(1), CYP1A2(2), CYP2A13(8), CYP2A6(1), CYP2A7(1), CYP2B6(5), CYP2C18(2), CYP2C19(6), CYP2C8(3), CYP2C9(3), CYP2D6(3), CYP2E1(2), CYP2F1(5), CYP3A4(4), CYP3A5(2), CYP3A7(5), CYP4B1(4), CYP4F8(1), CYP51A1(2), PON1(4) 41404914 82 58 81 26 12 20 15 25 10 0 0.536 1.000 1.000 502 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(7), ABP1(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), AOC2(6), AOC3(3), CNDP1(7), DPYD(2), DPYS(3), EHHADH(4), GAD1(3), GAD2(3), HADHA(3), HIBCH(2), MLYCD(4), SRM(4), UPB1(3) 37855468 72 58 71 22 9 17 19 14 13 0 0.602 1.000 1.000 503 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 31 ADRA1A(6), ADRA1B(1), ADRA2C(2), ADRB2(2), ADRB3(1), CHRM1(4), CHRM2(6), CHRM3(3), CHRM4(1), DRD1(1), DRD2(3), DRD3(1), DRD5(4), HRH1(4), HRH2(4), HTR1A(4), HTR1B(3), HTR1D(4), HTR1E(4), HTR1F(4), HTR2A(5), HTR2C(6), HTR5A(4) 35139381 77 58 77 32 25 11 11 20 10 0 0.703 1.000 1.000 504 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 24 APC(23), ASAH1(1), CASP3(1), CERK(2), CREB1(2), CREB3(1), CREB5(4), CXCL2(1), DAG1(2), EPHB2(5), FOS(1), GNAQ(1), ITPKA(1), ITPKB(8), JUN(3), MAP2K7(1), MAPK1(1), MAPK10(4), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(8), MAPK9(1) 37588224 76 58 76 19 16 17 11 18 13 1 0.413 1.000 1.000 505 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 23 ARNT(4), EIF2B1(3), EIF2B2(2), EIF2B3(2), EIF2B4(3), EIF2B5(4), EIF2S1(3), EIF2S2(3), EIF2S3(2), ELAVL1(4), FLT1(5), FLT4(3), HIF1A(4), HRAS(2), KDR(8), NOS3(3), PLCG1(8), PRKCA(4), PTK2(7), SHC1(2) 42847256 76 58 76 27 12 26 13 13 11 1 0.850 1.000 1.000 506 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(11), APOA1(3), APOA4(1), CETP(3), CYP7A1(3), DGAT1(2), HMGCR(5), LCAT(1), LDLR(6), LIPC(2), LPL(1), LRP1(28), SCARB1(5), SOAT1(2) 38168040 73 57 73 24 18 10 20 14 10 1 0.715 1.000 1.000 507 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 CALM2(2), CDKN1A(1), GNAQ(1), NFATC1(5), NFATC2(4), NFATC3(9), NFATC4(8), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(1), PRKCA(4), SP1(6), SP3(7), SYT1(2) 28015703 66 56 65 19 7 17 11 17 14 0 0.635 1.000 1.000 508 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 BLVRA(4), BLVRB(1), CP(8), EPRS(11), GUSB(6), HCCS(1), HMBS(3), HMOX2(1), PPOX(6), UGT1A1(4), UGT1A10(3), UGT1A3(3), UGT1A4(4), UGT1A6(2), UGT1A7(3), UGT1A8(2), UGT1A9(2), UGT2B15(5), UGT2B4(3), UROD(2), UROS(2) 39399533 76 56 75 30 5 22 17 22 9 1 0.952 1.000 1.000 509 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(7), DLG4(1), EPHB2(5), F2(2), F2RL1(1), F2RL2(2), JUN(3), MAP2K5(1), MAPK1(1), MAPK7(4), MAPK8(2), MYEF2(3), PLD1(7), PLD2(2), PLD3(2), PTK2(7), RAF1(4), RASAL1(5), SRC(1), TEC(6), VAV1(6) 39214541 72 56 72 21 20 19 12 12 9 0 0.441 1.000 1.000 510 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(4), ABAT(7), ACADS(2), ACAT1(3), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH5A1(2), ALDH9A1(1), EHHADH(4), GAD1(3), GAD2(3), HADHA(3), L2HGDH(2), OXCT1(5), PDHA1(2), PDHA2(4), PDHB(1), SDHB(2) 36716133 69 55 68 22 13 17 14 15 10 0 0.632 1.000 1.000 511 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 25 ABP1(1), ALDH1A3(7), ALDH3A1(3), ALDH3B2(4), AOC2(6), AOC3(3), DDC(4), EPX(4), ESCO1(4), ESCO2(1), GOT1(2), GOT2(1), HPD(4), LPO(4), MAOA(2), MAOB(4), MPO(5), PNPLA3(3), SH3GLB1(2), TAT(3), TPO(8) 47296678 75 55 74 21 17 16 11 16 14 1 0.532 1.000 1.000 512 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(1), ALOX15(4), ALOX5(3), CYP1A2(2), CYP2C18(2), CYP2C19(6), CYP2C8(3), CYP2C9(3), CYP2E1(2), CYP3A4(4), CYP3A43(3), CYP3A5(2), CYP3A7(5), HSD3B7(1), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), RDH11(4), RDH12(2), RDH13(2), RDH14(2) 34366289 70 55 70 20 8 20 15 18 9 0 0.453 1.000 1.000 513 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(8), CALM2(2), CAPN2(8), EP300(13), HDAC1(5), HDAC2(2), MEF2D(3), NFATC1(5), NFATC2(4), PPP3CA(5), PPP3CB(3), PPP3CC(1), PRKCA(4), SYT1(2) 33472411 65 55 65 23 8 15 12 15 15 0 0.905 1.000 1.000 514 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(9), AP2A1(6), AP2M1(4), BIN1(2), CALM2(2), DNM1(6), EPN1(4), EPS15(6), PICALM(3), PPP3CA(5), PPP3CB(3), PPP3CC(1), SYNJ1(4), SYNJ2(4), SYT1(2) 32273756 61 55 61 18 9 15 16 11 10 0 0.572 1.000 1.000 515 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(7), EXT2(6), EXTL1(1), EXTL2(1), EXTL3(6), GLCE(4), HS2ST1(3), HS3ST1(2), HS3ST2(4), HS3ST3A1(1), HS3ST3B1(1), HS3ST5(5), HS6ST1(5), HS6ST2(7), HS6ST3(3), NDST1(4), NDST2(1), NDST3(5) 29006389 66 54 64 21 15 17 4 17 13 0 0.757 1.000 1.000 516 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 12 ACTN1(6), ACTN2(10), ACTN3(7), BCAR1(6), CTNNA1(7), CTNNA2(14), CTNNB1(2), PTK2(7), SRC(1), VCL(6) 27042218 66 53 65 25 17 14 6 13 15 1 0.899 1.000 1.000 517 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(8), CD2(4), CD33(2), CD5(3), CD7(1), IFNA1(1), IFNG(2), IL12B(2), IL3(1), IL4(1), ITGAX(10), TLR2(3), TLR4(15), TLR7(9), TLR9(2) 26556607 64 53 63 22 7 15 17 14 11 0 0.710 1.000 1.000 518 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 12 APC(23), CREBBP(15), EP300(13), MAP2K1(5), MAP3K7(3), MAPK3(1), SKIL(3), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TGFBR2(4) 34639973 75 53 75 17 13 19 10 18 14 1 0.422 1.000 1.000 519 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 17 ADCY1(5), ARHGEF1(10), F2(2), F2R(4), GNA12(2), GNA13(1), GNAI1(2), GNAQ(1), GNB1(2), MAP3K7(3), PLCB1(13), PPP1R12B(4), PRKCA(4), PTK2B(7), ROCK1(8) 31023450 68 52 68 18 17 14 14 9 14 0 0.432 1.000 1.000 520 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(9), COL4A2(9), COL4A3(6), COL4A4(9), COL4A5(12), COL4A6(10), P4HB(2), SLC23A1(2), SLC23A2(8), SLC2A3(3) 37226074 70 52 70 26 12 16 18 11 13 0 0.853 1.000 1.000 521 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 26 ACAA1(1), ACAA2(2), ADH1A(1), ADH1C(4), ADH4(1), ADH6(2), ADH7(3), ADHFE1(2), AKR1C4(3), AKR1D1(1), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), BAAT(5), CEL(4), CYP27A1(1), CYP7A1(3), HADHB(3), SOAT2(2), SRD5A1(4) 32736870 64 51 63 24 13 11 20 8 12 0 0.831 1.000 1.000 522 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT3(2), AGPAT4(2), AGPAT6(3), AGPS(1), CHPT1(4), ENPP2(12), ENPP6(2), PAFAH1B1(3), PAFAH1B3(1), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLD1(7), PLD2(2), PPAP2A(2), PPAP2C(1) 33162628 62 51 62 17 6 19 14 14 9 0 0.423 1.000 1.000 523 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 66 MRPL13(2), MRPS7(3), RPL10L(1), RPL12(1), RPL13A(4), RPL18(1), RPL18A(4), RPL19(2), RPL22L1(1), RPL24(1), RPL26(1), RPL3(4), RPL31(1), RPL32(1), RPL35(1), RPL36A(2), RPL37A(1), RPL3L(3), RPL41(1), RPL7(1), RPL8(2), RPL9(1), RPS10(1), RPS12(1), RPS16(1), RPS18(1), RPS2(1), RPS25(1), RPS27(1), RPS29(1), RPS5(6), RPS6(4), RPS8(1), RPS9(2) 32146887 60 51 60 16 13 15 12 13 7 0 0.498 1.000 1.000 524 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(4), AGT(3), AGTR1(4), AGTR2(2), COL4A1(9), COL4A2(9), COL4A3(6), COL4A4(9), COL4A5(12), COL4A6(10), REN(1) 37339412 69 50 69 22 12 16 16 13 12 0 0.590 1.000 1.000 525 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(7), AGT(3), AGTR2(2), EDN1(5), EDNRA(3), EDNRB(2), EGF(5), EGFR(5), FOS(1), HRAS(2), JUN(3), MYC(1), NFKB1(5), PLCG1(8), PRKCA(4), RELA(3) 29202165 59 50 58 19 10 15 7 16 11 0 0.734 1.000 1.000 526 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(4), EGF(5), EGFR(5), HRAS(2), MAP2K1(5), MAPK1(1), MAPK3(1), PTPRB(12), RAF1(4), RASA1(2), SHC1(2), SOS1(5), SPRY1(7), SPRY2(2), SPRY3(6), SRC(1) 36090969 64 50 63 26 14 14 9 18 9 0 0.916 1.000 1.000 527 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 16 ABCB1(9), AKT1(2), ATM(23), BAX(3), CDKN1A(1), CPB2(4), CSNK1A1(4), FHL2(2), HIF1A(4), IGFBP3(1), MAPK8(2), MDM2(3), NFKBIB(2), NQO1(1) 27218151 61 49 60 19 9 20 8 11 13 0 0.865 1.000 1.000 528 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM2(2), CAMK1(1), CAMK1G(5), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CAMK4(5), HDAC5(6), MEF2A(6), MEF2C(4), MEF2D(3), PPARA(4), PPP3CA(5), PPP3CB(3), PPP3CC(1), SLC2A4(3), SYT1(2) 29818299 63 49 63 19 4 17 10 20 12 0 0.625 1.000 1.000 529 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(5), CREB1(2), CREBBP(15), EP300(13), NCOA3(9), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2), RARA(1), RXRA(2) 29299005 62 47 62 18 11 15 11 11 14 0 0.650 1.000 1.000 530 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(1), C1QB(1), C1R(6), C1S(1), C2(1), C3(8), C5(5), C6(8), C7(8), C8A(2), C9(5), MASP1(8), MASP2(2), MBL2(2) 30324581 58 47 58 19 9 17 14 11 7 0 0.781 1.000 1.000 531 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 23 ABP1(1), ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH3B2(4), ALDH9A1(1), AOC2(6), AOC3(3), ASPA(4), CNDP1(7), DDC(4), HAL(7), HARS(1), HNMT(2), MAOA(2), MAOB(4), PRPS2(1) 33799259 68 47 67 22 14 14 15 11 14 0 0.652 1.000 1.000 532 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(24), MAP2(18), PPP2CA(3), PRKACB(1), PRKACG(3), PRKAG1(2), PRKAR2A(3), PRKAR2B(2), PRKCE(8) 26140728 64 46 64 19 7 22 10 13 11 1 0.841 1.000 1.000 533 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 20 ADCY1(5), AKT1(2), ASAH1(1), GNAI1(2), GNB1(2), ITGAV(7), ITGB3(4), MAPK1(1), MAPK3(1), PDGFRA(6), PLCB1(13), PRKCA(4), PTK2(7), SMPD1(2), SMPD2(2), SPHK1(1), SRC(1) 33296479 61 46 61 17 18 14 6 12 11 0 0.529 1.000 1.000 534 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(3), GUSB(6), UGDH(1), UGP2(4), UGT1A1(4), UGT1A10(3), UGT1A3(3), UGT1A4(4), UGT1A6(2), UGT1A7(3), UGT1A8(2), UGT1A9(2), UGT2A1(7), UGT2B10(3), UGT2B11(1), UGT2B15(5), UGT2B17(2), UGT2B28(3), UGT2B4(3), UGT2B7(3), XYLB(2) 38200469 66 46 66 28 3 20 10 22 11 0 0.971 1.000 1.000 535 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(12), ABCC2(7), ABCG2(1), BCHE(6), CES1(4), CES2(2), CYP3A4(4), CYP3A5(2), UGT1A1(4), UGT1A10(3), UGT1A3(3), UGT1A4(4), UGT1A6(2), UGT1A7(3), UGT1A8(2), UGT1A9(2) 33175893 61 46 61 24 6 13 14 21 7 0 0.848 1.000 1.000 536 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 10 CD44(4), ICAM1(2), ITGA4(6), ITGAL(5), ITGAM(6), ITGB1(5), ITGB2(8), SELE(2), SELL(6), SELP(11) 23557680 55 46 55 18 7 12 12 14 10 0 0.746 1.000 1.000 537 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 9 CR1(14), CR2(5), HLA-DRB1(10), ICAM1(2), ITGAL(5), ITGB2(8), PTPRC(8) 21066449 52 45 52 22 4 16 14 10 7 1 0.926 1.000 1.000 538 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(3), EPHA4(5), EPHB1(12), ITGA1(6), ITGB1(5), L1CAM(10), LYN(6), RAP1B(1), SELP(11) 22796856 59 45 59 21 15 11 12 17 3 1 0.782 1.000 1.000 539 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(4), F13A1(5), F2(2), F2R(4), FGA(7), FGB(1), FGG(7), PLAT(6), PLAU(4), PLG(7), SERPINB2(1), SERPINE1(5) 19608259 53 45 53 21 5 13 12 13 10 0 0.940 1.000 1.000 540 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(10), AMT(1), ATIC(3), FTCD(2), GART(3), MTHFD1(9), MTHFD1L(5), MTHFR(6), MTHFS(2), MTR(5), SHMT1(1), SHMT2(4), TYMS(1) 27277911 52 45 51 16 5 18 9 6 14 0 0.690 1.000 1.000 541 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(3), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), CYP2C19(6), CYP2C9(3), DHRS2(4), DHRS3(1), DHRS7(4), DHRSX(1), EHHADH(4), ESCO1(4), ESCO2(1), HADHA(3), PNPLA3(3), SH3GLB1(2), YOD1(1) 44002064 57 45 56 14 9 16 10 14 7 1 0.379 1.000 1.000 542 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 22 POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2D(1), POLR2F(5), POLR2G(1), POLR2H(1), POLR2J(1), POLR3A(5), POLR3B(2), POLR3GL(3), POLR3H(1), POLR3K(1) 33332815 53 45 53 24 9 12 7 14 11 0 0.988 1.000 1.000 543 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(1), C1QB(1), C1R(6), C1S(1), C2(1), C3(8), C5(5), C6(8), C7(8), C8A(2), C8B(3), C9(5), MASP1(8) 29488256 57 44 57 18 8 18 14 10 7 0 0.754 1.000 1.000 544 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(4), BCAT2(5), COASY(4), DPYD(2), DPYS(3), ENPP1(7), ENPP3(6), ILVBL(5), PANK1(2), PANK2(1), PANK4(6), UPB1(3), VNN1(3) 24213883 51 44 51 18 10 10 11 11 9 0 0.803 1.000 1.000 545 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(10), AMT(1), ATIC(3), ATP6V0C(1), GART(3), MTHFD1(9), MTHFD1L(5), MTHFR(6), MTHFS(2), MTR(5), SHMT1(1), SHMT2(4), TYMS(1) 25943183 51 44 50 16 4 18 9 6 14 0 0.703 1.000 1.000 546 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(23), AXIN1(5), BTRC(4), CTNNB1(2), DLL1(5), DVL1(2), FZD1(3), GSK3B(2), NOTCH1(8), PSEN1(2) 27683188 56 44 56 20 8 15 11 14 6 2 0.928 1.000 1.000 547 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(3), ACTR2(2), ACTR3(2), ARPC1A(3), ARPC1B(2), ARPC2(5), NCK1(2), NCKAP1(9), NTRK1(8), PIR(2), PSMA7(3), WASF1(6), WASF2(3), WASF3(5), WASL(4) 22171512 59 43 58 15 6 22 14 6 10 1 0.503 1.000 1.000 548 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 13 AKT1(2), EGFR(5), IGF1R(7), MYC(1), POLR2A(6), PPP2CA(3), PRKCA(4), TEP1(16), TERT(2), TNKS(5), XRCC5(3) 36158068 54 43 53 21 6 13 8 16 10 1 0.928 1.000 1.000 549 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(5), ALDOB(3), ALDOC(2), FBP1(2), GOT1(2), GOT2(1), GPT(2), GPT2(3), MDH1(1), ME3(4), PGK1(6), PGK2(1), PKLR(5), TKT(3), TKTL1(3), TKTL2(3), TPI1(2) 28478508 48 42 48 16 9 16 9 8 6 0 0.564 1.000 1.000 550 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(9), ABCB11(13), ABCB4(10), ABCC1(12), ABCC3(9), GSTP1(1) 21319735 54 42 54 19 8 14 13 10 9 0 0.621 1.000 1.000 551 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 18 CSNK2A1(3), ELK1(4), FOS(1), HRAS(2), IGF1R(7), IRS1(4), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(2), PTPN11(1), RAF1(4), RASA1(2), SHC1(2), SOS1(5), SRF(1) 29017443 47 41 47 14 7 14 6 10 10 0 0.681 1.000 1.000 552 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(5), GTF2A1(2), GTF2E1(2), GTF2F1(1), HDAC3(1), NCOA1(5), NCOA2(6), NCOA3(9), NCOR2(8), POLR2A(6), RARA(1), RXRA(2), TBP(2) 35558465 50 41 50 28 5 10 9 13 13 0 0.999 1.000 1.000 553 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 24 BAG4(1), BIRC2(3), BIRC3(4), CASP3(1), CFLAR(1), JUN(3), MAP3K3(1), MAP3K7(3), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(2), NFKBIE(2), NR2C2(2), RALBP1(3), RIPK1(5), TNFAIP3(3), TNFRSF1A(4), TNFRSF1B(2), TRAF2(1) 33666759 54 41 53 18 11 18 8 5 12 0 0.762 1.000 1.000 554 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(5), ALDOB(3), ALDOC(2), FBP1(2), GOT1(2), GOT2(1), GPT(2), GPT2(3), MDH1(1), ME2(2), ME3(4), PGK1(6), PKLR(5), TKT(3), TPI1(2) 25415479 43 39 43 15 9 16 6 8 4 0 0.584 1.000 1.000 555 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(3), CYP51A1(2), DHCR24(4), DHCR7(1), EBP(1), FDFT1(4), FDPS(5), GGCX(3), GGPS1(2), HMGCR(5), HSD17B7(1), IDI1(7), IDI2(1), LSS(3), NQO1(1), NSDHL(3), PMVK(2), SQLE(2), VKORC1(1) 27365371 51 39 50 20 10 18 5 12 6 0 0.881 1.000 1.000 556 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(3), GALNT10(5), GALNT2(2), GALNT3(3), GALNT4(1), GALNT6(3), GALNT7(5), GALNT8(6), GALNT9(6), ST3GAL1(2), ST3GAL2(2), ST3GAL4(2), WBSCR17(7) 21132495 47 39 47 14 10 6 9 15 6 1 0.613 1.000 1.000 557 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(2), ARFGAP1(3), ARFGAP3(1), ARFGEF2(9), COPA(8), GBF1(8), GPLD1(5), KDELR1(2), KDELR2(2), KDELR3(2) 23442358 42 38 42 12 6 18 6 5 5 2 0.520 1.000 1.000 558 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(4), CSF1R(3), EGF(5), EGFR(5), MET(10), PDGFRA(6), PRKCA(4), SH3GLB1(2), SH3GLB2(1), SH3KBP1(9), SRC(1) 28180489 50 38 49 24 9 13 6 14 8 0 0.987 1.000 1.000 559 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(13), ACACB(13), FASN(14), MCAT(2), OLAH(1), OXSM(3) 21673574 46 38 46 14 7 14 7 9 9 0 0.579 1.000 1.000 560 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(4), BCAT2(5), IARS(8), IARS2(5), ILVBL(5), LARS(5), LARS2(3), PDHA1(2), PDHA2(4), PDHB(1), VARS(2), VARS2(1) 22928506 45 38 45 14 8 13 9 9 6 0 0.656 1.000 1.000 561 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(2), CLOCK(3), CRY1(2), CRY2(3), CSNK1E(4), NPAS2(8), NR1D1(5), PER1(10), PER2(8), PER3(9) 23701460 54 38 53 20 11 14 8 13 8 0 0.921 1.000 1.000 562 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 16 CSNK2A1(3), DPM2(1), ELK1(4), FOS(1), HRAS(2), JUN(3), KLK2(3), MAP2K1(5), MAPK3(1), MAPK8(2), NGFR(1), PLCG1(8), RAF1(4), SHC1(2), SOS1(5) 21242440 45 38 45 13 10 10 3 12 10 0 0.557 1.000 1.000 563 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(15), EP300(13), LPL(1), NCOA1(5), NCOA2(6), PPARG(5), RXRA(2) 26452967 47 38 46 17 9 9 8 10 11 0 0.908 1.000 1.000 564 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(1), C1QB(1), C1R(6), C1S(1), C2(1), C3(8), C5(5), C6(8), C7(8), C8A(2), C9(5) 24690044 46 37 46 13 6 15 12 8 5 0 0.639 1.000 1.000 565 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(1), ACAD9(4), ADH1A(1), ADH1C(4), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), DHRS2(4), DHRS3(1), DHRS7(4), DHRSX(1), ESCO1(4), ESCO2(1), PNPLA3(3), SH3GLB1(2) 35822664 43 37 43 10 4 14 11 10 3 1 0.409 1.000 1.000 566 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 28 CD4(4), CSF1(5), CSF3(2), HLA-DRB1(10), IFNA1(1), IFNG(2), IL11(1), IL12B(2), IL15(3), IL1A(1), IL3(1), IL4(1), IL6(2), IL7(1), IL8(1), LTA(2), TGFB1(2), TGFB2(1), TGFB3(1) 17950081 43 37 43 17 5 8 10 11 9 0 0.894 1.000 1.000 567 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(2), JAK1(11), PTPRU(10), REG1A(1), STAT1(4), STAT2(5), TYK2(8) 17648282 41 37 39 12 7 5 11 9 9 0 0.655 1.000 1.000 568 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(5), GNAS(11), GNB1(2), PPP2CA(3), PRKAA1(3), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKACB(1), PRKACG(3), PRKAG1(2), PRKAG2(2), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2) 21135409 47 36 47 15 12 10 8 8 9 0 0.775 1.000 1.000 569 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 11 CREBBP(15), DAXX(2), HRAS(2), PAX3(4), PML(3), RARA(1), SIRT1(2), SP100(9), TNFRSF1A(4), TNFRSF1B(2) 22068175 44 35 42 12 10 11 5 10 8 0 0.561 1.000 1.000 570 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(4), GABRA2(3), GABRA3(6), GABRA4(7), GABRA5(4), GABRA6(6), PRKCE(8), SOD1(1) 11331454 39 34 39 16 5 13 9 9 3 0 0.894 1.000 1.000 571 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(3), ACOT11(3), ACYP1(2), DHRS2(4), DHRS3(1), DHRS7(4), DHRSX(1), EHHADH(4), ESCO1(4), ESCO2(1), FN3K(3), GCDH(2), HADHA(3), PNPLA3(3), SH3GLB1(2), YOD1(1) 36893595 41 34 41 13 6 14 5 12 3 1 0.735 1.000 1.000 572 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 16 AKT1(2), EIF2B5(4), EIF2S1(3), EIF2S2(3), EIF2S3(2), GSK3B(2), IGF1R(7), INPPL1(6), PDK2(1), PDPK1(2), PPP2CA(3), RPS6(4), RPS6KB1(4) 21396445 43 34 43 16 6 19 8 4 5 1 0.850 1.000 1.000 573 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 8 CD44(4), ICAM1(2), ITGA4(6), ITGAL(5), ITGB1(5), ITGB2(8), SELE(2), SELL(6) 17658423 38 34 38 15 4 9 6 12 7 0 0.890 1.000 1.000 574 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(3), GUSB(6), UCHL3(2), UGDH(1), UGT1A1(4), UGT1A10(3), UGT1A3(3), UGT1A4(4), UGT1A6(2), UGT1A7(3), UGT1A8(2), UGT1A9(2), UGT2B15(5), UGT2B4(3) 25327862 43 34 43 22 2 10 8 17 6 0 0.984 1.000 1.000 575 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(2), DHCR7(1), FDFT1(4), FDPS(5), HMGCR(5), HMGCS1(6), IDI1(7), LSS(3), NSDHL(3), PMVK(2), SQLE(2) 18731033 40 33 39 14 7 14 4 9 6 0 0.796 1.000 1.000 576 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(5), POLD2(1), POLE(10), POLG(7), POLL(3), POLQ(12) 23689146 39 33 38 11 6 8 6 9 9 1 0.689 1.000 1.000 577 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT1(1), B3GAT2(1), B3GAT3(2), B4GALT7(1), CHPF(2), CHST11(1), CHST3(1), CHST7(1), CHSY1(3), DSE(11), UST(2), XYLT1(4), XYLT2(5) 17147745 35 33 35 16 15 8 3 6 3 0 0.890 1.000 1.000 578 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(4), ACO2(5), AFMID(1), CS(2), GRHPR(3), HAO1(5), HAO2(2), MDH1(1), MTHFD1(9), MTHFD1L(5) 19478363 37 33 37 13 7 15 6 4 5 0 0.603 1.000 1.000 579 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(13), CPT1A(6), LEP(1), LEPR(7), PRKAA1(3), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKAG1(2), PRKAG2(2) 21034208 38 33 38 16 5 10 6 8 9 0 0.956 1.000 1.000 580 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(4), COASY(4), DPYD(2), DPYS(3), ENPP1(7), ENPP3(6), PANK1(2), PANK2(1), PANK4(6), UPB1(3) 19314824 38 33 38 15 6 8 8 9 7 0 0.898 1.000 1.000 581 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5O(2), ATP6AP1(2), ATP6V0A1(6), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), FDXR(3), SHMT1(1) 23169551 45 33 45 19 8 15 8 5 9 0 0.876 1.000 1.000 582 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM2(2), CCL2(1), CCR5(1), CXCR4(3), FOS(1), GNAQ(1), JUN(3), MAPK14(2), MAPK8(2), PLCG1(8), PRKCA(4), PTK2B(7), SYT1(2) 19426835 37 32 37 11 7 8 6 6 10 0 0.678 1.000 1.000 583 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 14 CD28(2), CD3E(3), CD3G(3), CD86(6), CTLA4(1), HLA-DRB1(10), ICOS(3), ITK(7), LCK(2), PTPN11(1) 12270485 38 32 38 11 3 13 9 8 5 0 0.590 1.000 1.000 584 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(4), ACO2(5), CS(2), GRHPR(3), HAO1(5), HAO2(2), MDH1(1), MTHFD1(9), MTHFD1L(5) 18551378 36 32 36 12 7 15 6 3 5 0 0.531 1.000 1.000 585 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(6), LDLR(6), MBTPS1(3), MBTPS2(6), SCAP(2), SREBF1(4), SREBF2(6) 15959746 33 32 33 12 7 7 12 4 3 0 0.608 1.000 1.000 586 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(4), CD28(2), CD3E(3), CD3G(3), CD4(4), ICAM1(2), ITGAL(5), ITGB2(8), PTPRC(8), THY1(1) 16053129 40 32 40 15 3 11 10 8 8 0 0.770 1.000 1.000 587 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 10 AKT1(2), DPM2(1), HRAS(2), KLK2(3), NTRK1(8), PLCG1(8), PRKCA(4), SHC1(2), SOS1(5) 16716162 35 32 35 10 6 7 6 9 7 0 0.572 1.000 1.000 588 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(2), ATP6AP1(2), ATP6V0A1(6), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1) 22081292 42 31 42 19 7 15 8 4 8 0 0.921 1.000 1.000 589 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 9 EGF(5), EGFR(5), MAP2K1(5), MAPK14(2), NCOR2(8), RARA(1), RXRA(2), THRA(3), THRB(2) 20008441 33 31 32 13 4 6 7 7 9 0 0.919 1.000 1.000 590 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(2), ATP6AP1(2), ATP6V0A1(6), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1) 22081292 42 31 42 19 7 15 8 4 8 0 0.921 1.000 1.000 591 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 7 CD44(4), ICAM1(2), ITGAL(5), ITGAM(6), ITGB2(8), SELE(2), SELL(6) 15567842 33 31 33 12 4 8 6 6 9 0 0.764 1.000 1.000 592 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 12 AKT1(2), BCAR1(6), ILK(3), ITGB1(5), MAPK1(1), MAPK3(1), PDK2(1), PDPK1(2), PTK2(7), SHC1(2), SOS1(5) 19858403 35 31 35 10 6 8 5 9 6 1 0.646 1.000 1.000 593 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(2), ATP6AP1(2), ATP6V0A1(6), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(5), ATP6V1B2(4), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1) 22081292 42 31 42 19 7 15 8 4 8 0 0.921 1.000 1.000 594 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(8), C5(5), C6(8), C7(8), C8A(2), C9(5) 18626179 36 30 36 10 4 15 7 8 2 0 0.633 1.000 1.000 595 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM2(2), CAMK1(1), CAMK1G(5), CAMK2A(3), CAMK2B(3), CAMK2D(5), CAMK2G(2), CAMK4(5), CAMKK1(3), CAMKK2(4), CREB1(2), SYT1(2) 16458973 37 30 37 12 6 9 7 8 7 0 0.736 1.000 1.000 596 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), FDFT1(4), FDPS(5), HMGCR(5), IDI1(7), LSS(3), NQO1(1), NQO2(2), PMVK(2), SQLE(2), VKORC1(1) 15580074 33 29 32 12 7 11 4 7 4 0 0.804 1.000 1.000 597 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(2), CREM(3), FOS(1), JUN(3), MAPK3(1), OPRK1(2), POLR2A(6), PRKACB(1), PRKACG(3), PRKAR1A(6), PRKAR2A(3), PRKAR2B(2) 18215527 33 29 33 13 5 7 8 6 7 0 0.869 1.000 1.000 598 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(10), EGF(5), EGFR(5), HGS(6), TF(5), TFRC(2) 18311915 33 28 32 11 6 9 6 6 6 0 0.830 1.000 1.000 599 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(5), ABP1(1), AOC2(6), AOC3(3), CES1(4), DDHD1(4), ESCO1(4), ESCO2(1), LIPA(4), PLA1A(3), PNPLA3(3), PPME1(2), SH3GLB1(2) 35941837 42 28 42 14 5 9 12 11 4 1 0.777 1.000 1.000 600 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 9 CD3E(3), CD3G(3), CD4(4), HLA-DRB1(10), LCK(2), PTPRC(8), ZAP70(3) 12005239 33 28 33 18 2 8 9 7 7 0 0.989 1.000 1.000 601 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(3), CD3E(3), CD3G(3), HLA-A(3), ICAM1(2), ITGAL(5), ITGB2(8), PRF1(2) 11901415 29 27 28 15 4 8 4 9 4 0 0.940 1.000 1.000 602 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(4), EIF2AK4(10), EIF2B5(4), EIF2S1(3), EIF2S2(3), EIF2S3(2), EIF5(2), GSK3B(2) 16390263 30 27 30 12 3 13 5 6 3 0 0.922 1.000 1.000 603 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(4), ALDH1A2(1), ALDH1A3(7), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(1), EHHADH(4), HADHA(3) 17306805 29 26 28 11 5 5 9 4 6 0 0.816 1.000 1.000 604 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(17), GNA12(2), PRKACB(1), PRKACG(3), PRKAG1(2), PRKAR2A(3), PRKAR2B(2) 14373556 30 25 30 11 3 11 9 6 0 1 0.822 1.000 1.000 605 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 19 B3GNT1(1), B3GNT2(2), B3GNT3(1), B3GNT4(1), B3GNT5(4), B4GALT1(3), B4GALT3(2), B4GALT4(2), FUT1(1), FUT3(3), FUT5(2), FUT6(3), GCNT2(1), ST3GAL6(1), ST8SIA1(1) 20186507 28 25 28 12 6 8 4 7 3 0 0.856 1.000 1.000 606 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2D(1), POLR2F(5), POLR2G(1), POLR2H(1), POLR2J(1), POLRMT(5) 18080986 30 24 30 16 6 8 2 8 6 0 0.990 1.000 1.000 607 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(3), GPI(3), HK1(3), PFKL(1), PGK1(6), PKLR(5), TPI1(2) 12797847 23 22 23 10 2 7 4 5 5 0 0.824 1.000 1.000 608 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 16 ADAM10(3), ANKRD1(2), ATF3(2), CYR61(3), IFNG(2), IFRD1(2), IL18(2), IL1A(1), IL1R1(1), NR4A3(5), WDR1(1) 15390973 24 22 24 12 3 7 5 8 1 0 0.950 1.000 1.000 609 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 9 CCL11(1), CCR3(2), CD4(4), HLA-DRB1(10), IL4(1), IL5RA(4), IL6(2) 6922598 24 22 24 11 1 4 6 6 7 0 0.935 1.000 1.000 610 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(3), ACTR2(2), ACTR3(2), ARPC1A(3), ARPC1B(2), ARPC2(5), WASF1(6), WASL(4) 11850785 27 21 27 12 3 12 6 0 5 1 0.932 1.000 1.000 611 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(5), CYSLTR2(1), GPR161(6), GPR34(4), GPR39(3), GPR45(2), GPR65(1), GPR75(3) 14262818 25 20 25 11 2 4 2 13 4 0 0.894 1.000 1.000 612 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 12 ACTR2(2), ACTR3(2), ARPC1A(3), ARPC1B(2), ARPC2(5), PAK1(4), PDGFRA(6), WASL(4) 14109738 28 19 28 10 4 16 2 0 6 0 0.737 1.000 1.000 613 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(5), PARK2(3), SNCA(1), SNCAIP(7), UBE2F(1), UBE2L3(1), UBE2L6(2) 9042881 20 19 20 10 3 8 4 4 1 0 0.955 1.000 1.000 614 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(2), DCN(2), FMOD(1), KERA(3), LUM(2) 5254266 10 7 10 7 2 5 2 1 0 0 0.955 1.000 1.000 615 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 6 B3GNT1(1), FUT1(1), GCNT2(1), ST8SIA1(1) 7748235 4 4 4 6 0 1 0 3 0 0 0.998 1.000 1.000 616 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(2), LIPT1(1) 2217960 3 3 3 2 0 2 0 1 0 0 0.946 1.000 1.000