E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.017 0.095 -9999.0 0.0 -0.577 30.0 30.0 KLHL20 -0.008 0.032 -9999.0 0.0 -0.241 3.0 3.0 CYFIP2 -0.01 0.066 -9999.0 0.0 -0.357 31.0 31.0 Rac1/GDP 0.05 0.067 -9999.0 0.0 -0.437 2.0 2.0 ENAH -0.016 0.094 -9999.0 0.0 -0.573 30.0 30.0 AP1M1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.008 0.047 -9999.0 0.0 -0.492 1.0 1.0 ABI1/Sra1/Nap1 -0.006 0.024 -9999.0 0.0 -0.208 2.0 2.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.017 0.081 -9999.0 0.0 -0.47 32.0 32.0 RAPGEF1 0.039 0.088 -9999.0 0.0 -0.479 30.0 30.0 CTNND1 -0.0 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.017 0.098 -9999.0 0.0 -0.597 30.0 30.0 CRK 0.031 0.095 -9999.0 0.0 -0.529 30.0 30.0 E-cadherin/gamma catenin/alpha catenin -0.015 0.086 -9999.0 0.0 -0.518 31.0 31.0 alphaE/beta7 Integrin -0.006 0.04 -9999.0 0.0 -0.602 2.0 2.0 IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin -0.003 0.036 -9999.0 0.0 -0.478 6.0 6.0 DLG1 -0.016 0.094 -9999.0 0.0 -0.573 30.0 30.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.008 0.04 -9999.0 0.0 -0.311 2.0 2.0 MLLT4 -0.005 0.059 -9999.0 0.0 -0.719 7.0 7.0 ARF6/GTP/NME1/Tiam1 -0.007 0.029 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.011 0.051 -9999.0 0.0 -0.422 2.0 2.0 ARF6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.017 0.1 -9999.0 0.0 -0.602 31.0 31.0 TIAM1 -0.001 0.018 -9999.0 0.0 -0.293 4.0 4.0 E-cadherin(dimer)/Ca2+ -0.012 0.073 -9999.0 0.0 -0.445 30.0 30.0 AKT1 -0.006 0.029 -9999.0 0.0 -0.235 1.0 1.0 PIK3R1 -0.009 0.086 -9999.0 0.0 -0.79 13.0 13.0 CDH1 -0.022 0.129 -9999.0 0.0 -0.79 30.0 30.0 RhoA/GDP 0.049 0.067 -9999.0 0.0 -0.524 1.0 1.0 actin cytoskeleton organization -0.006 0.024 -9999.0 0.0 -0.175 3.0 3.0 CDC42/GDP 0.049 0.067 -9999.0 0.0 -0.524 1.0 1.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.01 0.055 -9999.0 0.0 -0.334 31.0 31.0 ITGB7 -0.01 0.058 -9999.0 0.0 -0.79 2.0 2.0 RAC1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.013 0.077 -9999.0 0.0 -0.47 30.0 30.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.012 0.074 -9999.0 0.0 -0.453 30.0 30.0 mol:GDP 0.046 0.078 -9999.0 0.0 -0.408 30.0 30.0 CDC42/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP -0.001 0.025 -9999.0 0.0 -0.541 2.0 2.0 p120 catenin/RhoA/GDP -0.01 0.058 -9999.0 0.0 -0.538 1.0 1.0 RAC1/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.007 0.029 -9999.0 0.0 -0.215 7.0 7.0 NME1 -0.015 0.064 -9999.0 0.0 -0.293 55.0 55.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.017 0.095 -9999.0 0.0 -0.568 31.0 31.0 regulation of cell-cell adhesion -0.007 0.041 -9999.0 0.0 -0.417 1.0 1.0 WASF2 -0.003 0.012 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.01 0.054 -9999.0 0.0 -0.584 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.016 0.076 -9999.0 0.0 -0.438 33.0 33.0 CCND1 -0.009 0.036 -9999.0 0.0 -0.27 7.0 7.0 VAV2 0.035 0.092 -9999.0 0.0 -0.507 30.0 30.0 RAP1/GDP -0.009 0.055 -9999.0 0.0 -0.563 1.0 1.0 adherens junction assembly -0.016 0.091 -9999.0 0.0 -0.546 31.0 31.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.015 0.072 -9999.0 0.0 -0.414 33.0 33.0 E-cadherin/beta catenin -0.013 0.08 -9999.0 0.0 -0.488 30.0 30.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.016 0.094 -9999.0 0.0 -0.573 30.0 30.0 PIK3CA -0.0 0.009 -9999.0 0.0 -0.293 1.0 1.0 Rac1/GTP -0.011 0.052 -9999.0 0.0 -0.401 3.0 3.0 E-cadherin/beta catenin/alpha catenin -0.014 0.085 -9999.0 0.0 -0.518 30.0 30.0 ITGAE 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.017 0.101 -9999.0 0.0 -0.613 30.0 30.0