E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.02 0.112 -9999.0 0.0 -0.408 45.0 45.0 KLHL20 0.016 0.065 0.242 8.0 -0.228 9.0 17.0 CYFIP2 0.028 0.048 0.254 26.0 -0.569 3.0 29.0 Rac1/GDP 0.001 0.085 0.263 6.0 -0.309 18.0 24.0 ENAH -0.015 0.105 -9999.0 0.0 -0.4 43.0 43.0 AP1M1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.009 0.047 -9999.0 0.0 -0.405 1.0 1.0 ABI1/Sra1/Nap1 -0.012 0.032 -9999.0 0.0 -0.159 11.0 11.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.047 0.067 -9999.0 0.0 -0.333 22.0 22.0 RAPGEF1 -0.018 0.106 0.262 1.0 -0.396 30.0 31.0 CTNND1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.021 0.123 -9999.0 0.0 -0.409 55.0 55.0 CRK -0.016 0.101 -9999.0 0.0 -0.39 43.0 43.0 E-cadherin/gamma catenin/alpha catenin 0.032 0.06 -9999.0 0.0 -0.362 20.0 20.0 alphaE/beta7 Integrin 0.037 0.034 -9999.0 0.0 -0.421 2.0 2.0 IQGAP1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.04 0.027 -9999.0 0.0 -0.331 3.0 3.0 DLG1 -0.023 0.118 -9999.0 0.0 -0.403 52.0 52.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.016 0.032 -9999.0 0.0 -0.24 2.0 2.0 MLLT4 0.021 0.033 0.254 1.0 -0.569 3.0 4.0 ARF6/GTP/NME1/Tiam1 0.044 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.004 0.046 -9999.0 0.0 -0.316 2.0 2.0 ARF6 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.021 0.065 -9999.0 0.0 -0.421 20.0 20.0 TIAM1 0.025 0.015 0.254 4.0 -9999.0 0.0 4.0 E-cadherin(dimer)/Ca2+ 0.04 0.056 -9999.0 0.0 -0.314 20.0 20.0 AKT1 -0.007 0.036 0.137 1.0 -0.21 1.0 2.0 PIK3R1 0.017 0.062 -9999.0 0.0 -0.569 12.0 12.0 CDH1 0.01 0.08 -9999.0 0.0 -0.569 20.0 20.0 RhoA/GDP 0.001 0.084 0.263 5.0 -0.31 18.0 23.0 actin cytoskeleton organization 0.015 0.053 0.185 20.0 -0.171 6.0 26.0 CDC42/GDP 0.002 0.083 0.263 5.0 -0.31 18.0 23.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.008 0.042 -9999.0 0.0 -0.266 20.0 20.0 ITGB7 0.03 0.046 0.254 30.0 -0.569 2.0 32.0 RAC1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.044 0.06 -9999.0 0.0 -0.333 20.0 20.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.03 0.052 -9999.0 0.0 -0.311 20.0 20.0 mol:GDP -0.012 0.091 0.27 5.0 -0.355 19.0 24.0 CDC42/GTP/IQGAP1 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.006 0.086 -9999.0 0.0 -0.317 18.0 18.0 RAC1/GTP/IQGAP1 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.035 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.014 0.047 0.176 39.0 -0.239 4.0 43.0 NME1 0.026 0.031 0.254 18.0 -9999.0 0.0 18.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.021 0.116 -9999.0 0.0 -0.41 48.0 48.0 regulation of cell-cell adhesion 0.004 0.04 -9999.0 0.0 -0.349 1.0 1.0 WASF2 0.008 0.026 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.013 0.058 0.245 1.0 -0.464 1.0 2.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.053 0.067 -9999.0 0.0 -0.316 21.0 21.0 CCND1 0.015 0.055 0.202 36.0 -0.301 4.0 40.0 VAV2 -0.019 0.148 -9999.0 0.0 -0.617 23.0 23.0 RAP1/GDP 0.007 0.07 0.264 3.0 -0.348 3.0 6.0 adherens junction assembly -0.021 0.113 -9999.0 0.0 -0.397 48.0 48.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.042 0.063 -9999.0 0.0 -0.306 21.0 21.0 E-cadherin/beta catenin 0.001 0.06 -9999.0 0.0 -0.344 30.0 30.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.023 0.117 -9999.0 0.0 -0.397 53.0 53.0 PIK3CA 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.005 0.089 0.253 34.0 -0.343 23.0 57.0 E-cadherin/beta catenin/alpha catenin 0.033 0.06 -9999.0 0.0 -0.362 20.0 20.0 ITGAE 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.022 0.126 -9999.0 0.0 -0.418 55.0 55.0