Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.014 0.14 0.422 85.0 -0.243 2.0 87.0 KIRREL -0.024 0.164 -9999.0 0.0 -0.573 87.0 87.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.014 0.14 0.244 2.0 -0.423 85.0 87.0 PLCG1 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.034 0.118 0.284 4.0 -0.321 84.0 88.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.008 0.089 0.236 1.0 -0.28 71.0 72.0 FYN 0.02 0.127 0.28 97.0 -0.307 83.0 180.0 mol:Ca2+ 0.031 0.113 0.307 1.0 -0.319 79.0 80.0 mol:DAG 0.032 0.114 0.312 1.0 -0.32 79.0 80.0 NPHS2 0.014 0.032 0.261 5.0 -9999.0 0.0 5.0 mol:IP3 0.032 0.114 0.312 1.0 -0.32 79.0 80.0 regulation of endocytosis 0.023 0.105 0.244 4.0 -0.291 83.0 87.0 Nephrin/NEPH1/podocin/Cholesterol 0.023 0.113 0.249 9.0 -0.319 84.0 93.0 establishment of cell polarity 0.014 0.14 0.243 2.0 -0.422 85.0 87.0 Nephrin/NEPH1/podocin/NCK1-2 0.043 0.114 0.316 1.0 -0.296 82.0 83.0 Nephrin/NEPH1/beta Arrestin2 0.026 0.107 0.252 4.0 -0.294 83.0 87.0 NPHS1 0.059 0.09 0.256 168.0 -9999.0 0.0 168.0 Nephrin/NEPH1/podocin 0.025 0.111 0.303 4.0 -0.308 83.0 87.0 TJP1 0.023 0.019 -9999.0 0.0 -0.569 1.0 1.0 NCK1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.033 0.115 0.317 1.0 -0.321 79.0 80.0 CD2AP 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.031 0.116 0.299 4.0 -0.321 81.0 85.0 GRB2 0.023 0.009 0.254 1.0 -9999.0 0.0 1.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.012 0.132 0.289 94.0 -0.307 89.0 183.0 cytoskeleton organization 0.003 0.108 0.273 16.0 -0.331 67.0 83.0 Nephrin/NEPH1 0.016 0.104 0.199 2.0 -0.299 85.0 87.0 Nephrin/NEPH1/ZO-1 0.025 0.121 -9999.0 0.0 -0.345 85.0 85.0