Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.012 0.043 -9999.0 0.0 -0.26 21.0 21.0 epithelial cell differentiation 0.036 0.054 -9999.0 0.0 -0.311 20.0 20.0 CYFIP2 0.028 0.048 0.254 26.0 -0.569 3.0 29.0 ENAH -0.003 0.06 0.295 11.0 -9999.0 0.0 11.0 EGFR -0.193 0.285 -9999.0 0.0 -0.569 393.0 393.0 EPHA2 0.021 0.041 -9999.0 0.0 -0.569 5.0 5.0 MYO6 -0.011 0.052 0.361 1.0 -0.301 21.0 22.0 CTNNB1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.049 0.034 -9999.0 0.0 -0.362 3.0 3.0 AQP5 -0.182 0.258 0.308 2.0 -0.497 416.0 418.0 CTNND1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.011 0.051 0.358 1.0 -0.297 20.0 21.0 regulation of calcium-dependent cell-cell adhesion -0.022 0.075 0.358 1.0 -0.296 63.0 64.0 EGF -0.084 0.229 0.254 2.0 -0.569 196.0 198.0 NCKAP1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.016 0.118 0.287 1.0 -0.47 54.0 55.0 cortical microtubule organization 0.036 0.054 -9999.0 0.0 -0.311 20.0 20.0 GO:0000145 -0.011 0.048 0.351 1.0 -0.283 20.0 21.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.04 0.056 -9999.0 0.0 -0.314 20.0 20.0 MLLT4 0.021 0.033 0.254 1.0 -0.569 3.0 4.0 ARF6/GDP -0.02 0.039 -9999.0 0.0 -0.278 3.0 3.0 ARF6 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.045 0.038 -9999.0 0.0 -0.33 5.0 5.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.001 0.05 -9999.0 0.0 -0.283 20.0 20.0 PVRL2 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.011 0.051 0.361 1.0 -0.3 20.0 21.0 ARF6/GTP 0.049 0.04 -9999.0 0.0 -0.309 5.0 5.0 CDH1 0.01 0.08 -9999.0 0.0 -0.569 20.0 20.0 EGFR/EGFR/EGF/EGF -0.144 0.197 -9999.0 0.0 -0.332 522.0 522.0 RhoA/GDP 0.037 0.053 -9999.0 0.0 -0.298 20.0 20.0 actin cytoskeleton organization -0.013 0.049 0.343 1.0 -0.293 21.0 22.0 IGF-1R heterotetramer 0.013 0.079 0.254 3.0 -0.568 19.0 22.0 GIT1 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.013 0.079 0.254 3.0 -0.569 19.0 22.0 IGF1 -0.104 0.244 -9999.0 0.0 -0.569 232.0 232.0 DIAPH1 0.026 0.1 -9999.0 0.0 -0.554 15.0 15.0 Wnt receptor signaling pathway -0.036 0.054 0.311 20.0 -9999.0 0.0 20.0 RHOA 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.02 0.039 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.013 0.05 0.346 1.0 -0.3 21.0 22.0 EFNA1 0.02 0.009 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.015 0.053 -9999.0 0.0 -0.291 27.0 27.0 Ephrin A1/EPHA2 0.025 0.053 -9999.0 0.0 -0.293 22.0 22.0 SEC6/SEC8 -0.021 0.042 -9999.0 0.0 -0.295 21.0 21.0 MGAT3 -0.023 0.076 0.361 1.0 -0.3 63.0 64.0 HGF/MET -0.04 0.153 -9999.0 0.0 -0.317 234.0 234.0 HGF -0.011 0.142 0.254 2.0 -0.569 65.0 67.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.012 0.043 -9999.0 0.0 -0.261 21.0 21.0 actin cable formation 0.042 0.095 0.336 30.0 -0.292 1.0 31.0 KIAA1543 -0.012 0.054 0.354 1.0 -0.327 20.0 21.0 KIFC3 -0.012 0.049 0.361 1.0 -0.301 20.0 21.0 NCK1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.012 0.05 -9999.0 0.0 -0.301 20.0 20.0 NCK1/GIT1 0.033 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.036 0.054 -9999.0 0.0 -0.311 20.0 20.0 EXOC4 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.011 0.049 0.361 1.0 -0.301 19.0 20.0 PIP5K1C -0.011 0.051 0.361 1.0 -0.301 20.0 21.0 LIMA1 0.024 0.018 -9999.0 0.0 -0.569 1.0 1.0 ABI1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.018 0.089 0.312 26.0 -9999.0 0.0 26.0 adherens junction assembly -0.021 0.102 0.298 3.0 -0.61 17.0 20.0 IGF-1R heterotetramer/IGF1 -0.042 0.148 -9999.0 0.0 -0.308 237.0 237.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.032 0.029 -9999.0 0.0 -0.297 6.0 6.0 MET -0.074 0.22 -9999.0 0.0 -0.569 177.0 177.0 PLEKHA7 -0.012 0.057 0.361 1.0 -0.343 20.0 21.0 mol:GTP 0.043 0.037 -9999.0 0.0 -0.328 5.0 5.0 establishment of epithelial cell apical/basal polarity -0.008 0.067 0.367 7.0 -0.515 1.0 8.0 cortical actin cytoskeleton stabilization 0.012 0.043 -9999.0 0.0 -0.26 21.0 21.0 regulation of cell-cell adhesion -0.013 0.049 0.343 1.0 -0.293 21.0 22.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.012 0.043 -9999.0 0.0 -0.261 21.0 21.0