rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(3), ITGB1(2), MAPK1(9), MAPK3(1), PDK2(1), PDPK1(2), PIK3CA(58), PIK3R1(10), PTEN(17), PTK2(2), SOS1(5) 5594594 110 76 62 6 73 5 10 9 13 0 2.02e-06 <1.00e-15 <3.93e-13 2 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(3), AKT2(1), AKT3(3), MAPK1(9), MAPK3(1), PDK1(3), PIK3CA(58), PIK3CD(1), PTEN(17), PTK2B(3), RBL2(2), SOS1(5) 5880977 106 74 58 6 74 2 8 8 14 0 4.31e-07 1.78e-15 3.93e-13 3 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(3), BAD(2), CHRNB1(1), CHRNG(1), MUSK(3), PIK3CA(58), PIK3R1(10), PTK2(2), PTK2B(3), RAPSN(1), TERT(1) 4886895 85 69 45 5 55 3 11 10 6 0 7.85e-07 2.66e-15 3.93e-13 4 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(3), CREB1(2), MAP2K1(2), MAP2K3(2), MAP3K1(4), MAPK1(9), MAPK3(1), NFKB1(2), PIK3CA(58), PIK3R1(10), RB1(9), RELA(7), SP1(3) 5748570 112 75 66 7 76 5 13 10 7 1 3.10e-06 3.22e-15 3.93e-13 5 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(3), HLA-A(17), ITGB1(2), KLRC4(1), KLRD1(2), LAT(1), MAP2K1(2), MAPK3(1), PAK1(1), PIK3CA(58), PIK3R1(10), PTK2B(3), RAC1(1), SYK(1), VAV1(2) 5484583 105 78 63 7 60 2 13 10 20 0 4.39e-06 4.66e-15 3.93e-13 6 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(3), CREB1(2), HRAS(1), MAPK1(9), MAPK3(1), MAPK7(2), MEF2A(1), MEF2B(1), MEF2C(1), MEF2D(3), PIK3CA(58), PIK3R1(10), PLCG1(3), RPS6KA1(1) 5735427 96 73 50 5 67 4 12 9 4 0 1.71e-07 4.66e-15 3.93e-13 7 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD3D(2), HLA-DRA(1), HLA-DRB1(1), ITK(1), PIK3CA(58), PIK3R1(10) 3581149 73 60 34 1 51 4 8 8 2 0 1.34e-07 5.00e-15 3.93e-13 8 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(1), ARPC1A(2), ARPC2(3), CDC42(1), PAK1(1), PDGFRA(2), PIK3CA(58), PIK3R1(10), RAC1(1), WASL(4) 3919913 83 66 44 4 58 2 9 9 5 0 1.08e-05 5.11e-15 3.93e-13 9 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(3), PIK3CA(58), PIK3R1(10), PLCB1(10), PLCG1(3), PRKCA(3), VAV1(2) 3764925 89 70 49 5 65 2 9 9 4 0 3.81e-06 6.88e-15 4.71e-13 10 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(3), BAD(2), CASP9(1), CHUK(2), GHR(6), NFKB1(2), NFKBIA(2), PDPK1(2), PIK3CA(58), PIK3R1(10), RELA(7) 4124019 95 71 55 7 64 4 11 10 6 0 6.49e-05 9.66e-15 5.95e-13 11 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(3), EIF4A1(3), EIF4A2(3), EIF4G1(5), EIF4G3(4), GHR(6), IRS1(2), MAPK1(9), MAPK3(1), MKNK1(1), PDK2(1), PDPK1(2), PIK3CA(58), PIK3R1(10), PRKCA(3), PTEN(17), RPS6KB1(1) 8149602 129 81 81 8 85 5 13 9 17 0 9.67e-07 1.70e-14 9.51e-13 12 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(2), AKT1(3), CALM1(2), CALM3(1), GNAS(6), GNB1(1), GNGT1(1), NFKB1(2), NOS3(6), NPPA(1), NR3C1(4), PIK3CA(58), PIK3R1(10), RELA(7), SYT1(2) 5184985 106 71 66 7 72 4 14 10 6 0 7.48e-06 3.24e-14 1.66e-12 13 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(4), ARHGEF1(1), F2R(1), F2RL3(2), GNA12(2), GNA13(3), GNAI1(1), GNAQ(2), GNB1(1), GNGT1(1), PIK3CA(58), PIK3R1(10), PLCB1(10), PPP1R12B(3), PRKCA(3), PTK2B(3), ROCK1(3) 7444183 108 79 69 7 74 2 13 11 8 0 9.38e-07 2.43e-13 1.15e-11 14 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(3), HRAS(1), KLK2(3), PIK3CA(58), PIK3R1(10), PLCG1(3), PRKCA(3), SOS1(5) 4539864 86 64 45 6 62 3 10 9 2 0 1.77e-05 3.40e-13 1.50e-11 15 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(3), AKT2(1), AKT3(3), CDKN1A(1), ELK1(2), HRAS(1), MAP2K1(2), NGFR(1), PIK3CA(58), PIK3CD(1), SOS1(5) 4762342 78 63 38 6 57 2 10 8 1 0 2.92e-05 1.64e-12 6.72e-11 16 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 ELK1(2), FOS(2), HRAS(1), JUN(2), KLK2(3), MAP2K1(2), MAPK3(1), MAPK8(1), NGFR(1), PIK3CA(58), PIK3R1(10), PLCG1(3), SOS1(5) 5494166 91 65 51 8 61 3 14 9 4 0 9.41e-05 1.53e-09 5.90e-08 17 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(15), EP300(23), FYN(3), JAK1(1), JAK3(4), NMI(1), PIK3CA(58), PIK3R1(10), PTK2B(3), STAT5A(2), STAT5B(1) 8192289 121 79 77 11 71 4 19 8 15 4 3.14e-06 1.71e-09 6.21e-08 18 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(3), EIF2B5(1), EIF2S1(3), EIF2S2(2), IGF1R(3), INPPL1(4), PDK2(1), PDPK1(2), PIK3CA(58), PIK3R1(10), PTEN(17), RPS6KB1(1) 5720714 105 73 63 10 68 4 10 9 14 0 8.41e-05 4.11e-08 1.41e-06 19 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(4), AKT1(3), ASAH1(2), GNAI1(1), GNB1(1), GNGT1(1), ITGAV(1), ITGB3(3), MAPK1(9), MAPK3(1), PDGFRA(2), PIK3CA(58), PIK3R1(10), PLCB1(10), PRKCA(3), PTK2(2), RAC1(1), SMPD1(3), SMPD2(1), SPHK1(1) 7937044 117 79 71 11 85 3 13 10 6 0 3.50e-06 3.91e-07 1.27e-05 20 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 AKT1(3), CAT(2), GHR(6), HRAS(1), IGF1R(3), PIK3CA(58), PIK3R1(10) 3805901 83 65 43 10 56 3 12 9 3 0 0.00148 5.74e-07 1.77e-05 21 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(15), EP300(23), ESR1(1), MAPK1(9), MAPK3(1) 4371906 49 42 38 5 25 2 6 1 11 4 0.00673 1.05e-06 3.09e-05 22 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(8), CDKN2A(4), MDM2(1), MYC(1), PIK3CA(58), PIK3R1(10), POLR1A(7), POLR1B(3), POLR1C(3), RAC1(1), RB1(9), TBX2(1), TP53(12), TWIST1(1) 5699329 119 82 79 14 74 4 19 11 10 1 0.000315 2.25e-06 6.31e-05 23 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 24 GHR(6), HRAS(1), INSR(4), IRS1(2), JAK2(6), MAP2K1(2), MAPK1(9), MAPK3(1), PIK3CA(58), PIK3R1(10), PLCG1(3), PRKCA(3), RPS6KA1(1), SOS1(5), STAT5A(2), STAT5B(1) 9569701 114 78 69 11 76 5 16 10 6 1 5.95e-06 3.70e-05 0.000991 24 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(3), NFYB(1), NFYC(1), RB1(9), SP1(3), SP3(2) 1945598 19 18 19 1 9 2 3 0 4 1 0.0818 3.95e-05 0.00101 25 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(3), BAD(2), HRAS(1), IGF1R(3), IRS1(2), MAP2K1(2), MAPK1(9), MAPK3(1), PIK3CA(58), PIK3R1(10), SOS1(5) 5469289 96 71 50 12 68 4 12 9 3 0 0.00112 6.45e-05 0.00159 26 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(3), CCND1(1), CDK2(1), CDKN1A(1), HRAS(1), MAPK1(9), MAPK3(1), NFKB1(2), NFKBIA(2), PAK1(1), PIK3CA(58), PIK3R1(10), RAC1(1), RB1(9), RELA(7), TFDP1(2) 5917234 109 77 63 13 72 6 13 10 7 1 0.000522 7.81e-05 0.00185 27 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 CRK(1), CXCR4(3), GNAI1(1), GNAQ(2), GNB1(1), GNGT1(1), HRAS(1), MAP2K1(2), MAPK1(9), MAPK3(1), NFKB1(2), PIK3C2G(5), PIK3CA(58), PIK3R1(10), PLCG1(3), PRKCA(3), PTK2(2), PTK2B(3), PXN(2), RELA(7) 8148333 117 78 72 12 77 4 17 13 6 0 2.04e-05 0.000312 0.00711 28 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP3(1), CASP8(9), PDE6D(2) 1106311 12 12 11 1 3 0 2 2 5 0 0.153 0.000448 0.00985 29 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(4), AKT1(3), CAMK2A(3), CAMK2B(1), CAMK2D(2), CREB1(2), GNAS(6), HRAS(1), MAPK1(9), MAPK3(1), PIK3CA(58), PIK3R1(10), PRKAR2A(1), PRKCA(3), RAC1(1), RPS6KA1(1), RPS6KA5(2), SOS1(5) 8392728 113 77 67 12 79 3 17 10 4 0 6.30e-05 0.000553 0.0117 30 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(3), BAD(2), CASP9(1), CDC42(1), CHUK(2), ELK1(2), H2AFX(1), HRAS(1), MAP2K1(2), MAPK3(1), NFKB1(2), PIK3CA(58), PIK3R1(10), RAC1(1), RALA(1), RALBP1(3), RALGDS(2), RELA(7), RHOA(2) 5717827 102 70 62 12 71 4 13 9 5 0 0.000459 0.000682 0.0140 31 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 ELK1(2), FOS(2), HRAS(1), INSR(4), IRS1(2), JUN(2), MAP2K1(2), MAPK3(1), MAPK8(1), PIK3CA(58), PIK3R1(10), RASA1(4), SOS1(5) 7398496 94 67 55 10 60 4 16 9 5 0 0.000275 0.00320 0.0636 32 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(2), BFAR(3), BRAF(2), CREB1(2), CREB3(1), CREB5(5), MAPK1(9), SNX13(2) 3323824 26 23 20 2 18 1 5 0 2 0 0.0338 0.00441 0.0848 33 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 12 CREB1(2), FOS(2), JUN(2), KEAP1(1), MAPK1(9), MAPK8(1), NFE2L2(16), PRKCA(3) 2605978 36 31 28 5 26 2 4 1 3 0 0.0576 0.00551 0.103 34 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(3), CD3D(2), GZMB(1), HLA-A(17), ITGAL(4), PRF1(1) 2492037 28 20 25 5 6 2 4 1 15 0 0.0796 0.0101 0.184 35 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(3), IL8(2) 496037 5 5 5 0 1 1 2 0 1 0 0.352 0.0132 0.232 36 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(3), ASPH(5), COPS5(2), CREB1(2), EDN1(1), EP300(23), HIF1A(5), JUN(2), NOS3(6), P4HB(2) 4965944 51 37 47 5 26 2 8 0 12 3 0.0115 0.0162 0.277 37 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(3), APC(7), CCND1(1), CD14(3), CTNNB1(5), FZD1(1), GJA1(2), GNAI1(1), IRAK1(3), LEF1(1), LY96(2), NFKB1(2), PDPK1(2), PIK3CA(58), PIK3R1(10), RELA(7), TLR4(2), TOLLIP(1), WNT1(1) 8776566 112 75 70 11 75 5 14 12 6 0 0.000138 0.0170 0.283 38 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(1), AKT1(3), AKT2(1), AKT3(3), BAD(2), BTK(4), CDKN2A(4), DAPP1(1), GSK3A(3), INPP5D(4), PDK1(3), PIK3CA(58), PPP1R13B(2), PTEN(17), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), SFN(1), SOS1(5), SOS2(5), YWHAE(2), YWHAQ(2), YWHAZ(3) 10424913 130 83 88 16 82 2 14 14 18 0 0.000437 0.0217 0.352 39 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(3), BCR(2), FOS(2), HRAS(1), JAK2(6), JUN(2), MAP2K1(2), MAP3K1(4), MAPK3(1), MAPK8(1), MYC(1), PIK3CA(58), PIK3R1(10), SOS1(5), STAT1(2), STAT5A(2), STAT5B(1) 8012868 103 71 63 14 66 4 16 10 6 1 0.00257 0.0335 0.529 40 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CDK2(1), CUL1(4), FBXW7(20), RB1(9), TFDP1(2) 2479477 36 31 30 7 14 3 8 1 9 1 0.254 0.0347 0.534 41 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5R1(1), EGR1(3), HRAS(1), KLK2(3), MAP2K1(2), MAPK1(9), MAPK3(1), NGFR(1) 2384544 21 18 14 3 16 0 4 0 1 0 0.0487 0.0481 0.720 42 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(2), CDK5R1(1), CHN1(2), LIMK1(4), MAP3K1(4), MYLK(2), NCF2(2), PAK1(1), PDGFRA(2), PIK3CA(58), PIK3R1(10), PLD1(3), PPP1R12B(3), RAC1(1), RALBP1(3), RPS6KB1(1), TRIO(7), VAV1(2), WASF1(3) 10202015 111 79 72 14 68 4 19 13 7 0 0.000714 0.0497 0.720 43 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(4), GNAS(6), GNB1(1), GNGT1(1), PRKACA(2) 1769339 14 14 14 1 7 1 4 1 1 0 0.0763 0.0513 0.720 44 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(3), EIF2B2(2), EIF2B4(2), EIF2B5(1), EIF2S1(3), EIF2S2(2), ELAVL1(2), FLT1(7), FLT4(7), HIF1A(5), HRAS(1), KDR(2), NOS3(6), PIK3CA(58), PIK3R1(10), PLCG1(3), PRKCA(3), PTK2(2), PXN(2) 10062771 121 72 82 14 79 3 19 10 10 0 6.25e-05 0.0514 0.720 45 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(15), EP300(23), LPL(2), NCOA1(4), NCOA2(2), PPARG(1), RXRA(1) 5390974 48 41 42 7 20 2 10 0 12 4 0.0739 0.0590 0.790 46 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(1), CREB1(2), CREBBP(15), EP300(23), NCOA3(1), PRKAR2A(1), RXRA(1) 6034736 44 38 39 6 18 2 9 0 11 4 0.0452 0.0590 0.790 47 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(2), CD4(1), FYN(3), HLA-DRA(1), HLA-DRB1(1), PTPRC(10), ZAP70(2) 2462474 20 19 20 3 9 3 3 1 4 0 0.173 0.0618 0.810 48 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(1), GNAQ(2), GNB1(1), GNGT1(1), HTR2C(2), PLCB1(10), TUB(3) 2066687 20 18 20 3 11 1 3 4 1 0 0.145 0.0665 0.854 49 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(7), CREBBP(15), CTNNB1(5), EP300(23), FZD1(1), LDB1(4), LEF1(1), PITX2(2), TRRAP(13), WNT1(1) 9550997 72 51 65 9 32 4 14 3 15 4 0.00523 0.0731 0.919 50 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(7), CDH1(2), CREBBP(15), EP300(23), MAP2K1(2), MAPK3(1), SKIL(2), TGFB2(1), TGFB3(2), TGFBR1(1), TGFBR2(5) 7515821 61 48 55 9 28 2 8 2 17 4 0.0858 0.0762 0.939 51 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(3), GSTZ1(1), HGD(2) 656562 6 6 6 0 5 0 0 1 0 0 0.145 0.0783 0.945 52 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(1), IFNGR1(6), IFNGR2(3), JAK1(1), JAK2(6), STAT1(2) 2394449 19 18 18 3 9 2 0 0 7 1 0.325 0.0853 1.000 53 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 33 DUSP1(1), GORASP1(1), MAP2K7(1), MAPK1(9), MAPK11(2), MAPK13(1), MAPK3(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(2), MAPK9(4), MAPKAPK5(1), NFKB1(2), NFKB2(1), NFKBIA(2), NFKBIE(2), PIK3CA(58), PIK3CD(1), PIK3R1(10), SYT1(2), TRAF2(1), TRAF3(3), TRAF5(1), TRAF6(1) 9832629 110 79 64 16 79 3 15 8 5 0 0.001000 0.0896 1.000 54 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(1), JAK2(6), JAK3(4), MAPK1(9), MAPK3(1), STAT3(2), TYK2(9) 3424852 32 26 26 5 21 1 3 1 4 2 0.0483 0.111 1.000 55 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(2), F13B(2), HSD17B4(10), HSD17B7(2), HSD3B1(2), HSD3B2(1) 2356166 19 14 19 2 10 0 4 3 2 0 0.0739 0.114 1.000 56 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), HADH(1), HSD17B10(1), HSD17B4(10), MECR(1), PPT1(1), PPT2(1) 2402078 16 13 16 1 7 2 3 2 2 0 0.0618 0.116 1.000 57 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(3), AKT2(1), AKT3(3), IL4R(5), INPP5D(4), JAK1(1), JAK2(6), JAK3(4), PIK3CA(58), PPP1R13B(2), RPS6KB1(1), SERPINA4(2), SOS1(5), SOS2(5), STAT6(3), TYK2(9) 10719671 112 75 71 14 73 4 16 11 6 2 0.000223 0.137 1.000 58 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 33 AKT1(3), BAD(2), CBL(1), FOS(2), HRAS(1), IRS1(2), JAK1(1), JAK3(4), MAPK1(9), MAPK3(1), MYC(1), NMI(1), PIK3CA(58), PIK3R1(10), RPS6KB1(1), SOCS3(6), SOS1(5), STAT5A(2), STAT5B(1), SYK(1) 10420731 112 77 66 15 78 4 16 9 5 0 0.000317 0.139 1.000 59 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(3), EIF4A1(3), EIF4A2(3), EIF4B(3), EIF4G1(5), EIF4G3(4), MKNK1(1), PDK2(1), PDPK1(2), PIK3CA(58), PIK3R1(10), PTEN(17), RPS6KB1(1), TSC1(2), TSC2(6) 8133330 119 76 77 16 75 6 13 8 17 0 0.00382 0.142 1.000 60 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD34(2), CD3D(2), CD4(1), CD58(2), CD8A(2), IL6(1), IL8(2), KITLG(1) 1811898 13 10 13 2 5 2 3 0 3 0 0.318 0.156 1.000 61 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(3), AKT2(1), AKT3(3), BCR(2), BTK(4), CD19(1), CDKN2A(4), DAPP1(1), FLOT2(2), GAB1(2), ITPR1(8), ITPR2(5), ITPR3(2), PDK1(3), PIK3CA(58), PITX2(2), PLCG2(4), PPP1R13B(2), PREX1(10), PTEN(17), PTPRC(10), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), SAG(1), SYK(1), VAV1(2) 16066983 154 91 112 20 97 4 14 14 25 0 1.62e-05 0.157 1.000 62 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(1), CD4(1), HLA-DRA(1), HLA-DRB1(1), IL5(1), IL5RA(2), IL6(1) 1420729 8 8 8 1 4 2 2 0 0 0 0.227 0.162 1.000 63 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(1), HLA-DRA(1), HLA-DRB1(1), IL5(1) 746468 4 4 4 1 2 2 0 0 0 0 0.462 0.168 1.000 64 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(3), COQ5(2), COQ6(1), COQ7(1), NDUFB11(3) 1217340 10 10 10 2 5 0 3 0 2 0 0.532 0.171 1.000 65 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(1), PGLYRP2(2) 504526 3 3 3 1 1 1 0 0 1 0 0.726 0.176 1.000 66 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(1), IFNG(1), IL12A(2), IL12B(2) 892904 6 6 6 1 5 0 0 0 1 0 0.551 0.182 1.000 67 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(5), APOBEC1(1), APOBEC3B(1), APOBEC3F(2), APOBEC3G(6), APOBEC4(3) 2134444 18 16 18 3 7 1 8 0 2 0 0.184 0.188 1.000 68 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 FUT1(2), FUT2(3), FUT9(3), GCNT2(3), ST8SIA1(2) 1763764 13 11 13 1 5 1 4 1 2 0 0.0670 0.189 1.000 69 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 25 AKT1(3), AKT2(1), AKT3(3), BAD(2), GSK3A(3), IL4R(5), IRS1(2), JAK1(1), JAK3(4), MAP4K1(3), MAPK1(9), MAPK3(1), PDK1(3), PIK3CA(58), PIK3CD(1), PIK3R1(10), PPP1R13B(2), SOS1(5), SOS2(5), STAT6(3) 10265256 124 78 78 17 83 4 19 10 8 0 0.000328 0.192 1.000 70 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(1), CYP11A1(3), CYP11B2(3), CYP17A1(2), HSD11B2(1), HSD3B1(2), HSD3B2(1) 1998939 13 12 13 2 5 0 5 1 2 0 0.117 0.199 1.000 71 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 FOS(2), HRAS(1), JAK2(6), JUN(2), MAP2K1(2), MAPK3(1), MPL(1), PIK3CA(58), PIK3R1(10), PLCG1(3), PRKCA(3), RASA1(4), SOS1(5), STAT1(2), STAT3(2), STAT5A(2), STAT5B(1), THPO(1) 8707354 106 72 67 15 68 4 16 9 8 1 0.00276 0.200 1.000 72 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 4 FOSB(3), GRIA2(2) 1032150 5 5 5 1 2 0 1 2 0 0 0.576 0.251 1.000 73 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(4), AKT1(3), BAD(2), CSF2RB(2), IGF1R(3), IL3RA(2), KIT(3), KITLG(1), PIK3CA(58), PIK3R1(10), PRKAR2A(1) 6340294 89 69 49 16 62 3 11 9 4 0 0.00574 0.257 1.000 74 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA11(1), NDUFA5(1), NDUFA8(1), NDUFB7(2), NDUFS1(1), NDUFS2(1), NDUFV1(3) 2085754 11 10 11 0 4 1 2 0 4 0 0.0820 0.265 1.000 75 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(1), CYP2C9(3) 584680 4 4 4 1 3 0 1 0 0 0 0.561 0.267 1.000 76 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT2(1), TAT(3) 760205 4 4 4 0 2 0 2 0 0 0 0.292 0.273 1.000 77 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD4(1), HLA-DRA(1), HLA-DRB1(1) 553381 3 3 3 1 2 1 0 0 0 0 0.600 0.274 1.000 78 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(2), CHAT(2), CHKA(2), PCYT1A(2), PDHA1(1), PDHA2(4), PEMT(1), SLC18A3(1) 1986878 15 14 14 3 6 1 6 1 1 0 0.268 0.281 1.000 79 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 CREBBP(15), DFFA(1), DFFB(1), GZMA(1), GZMB(1), HMGB2(1), PRF1(1), SET(2) 3142891 23 19 22 4 9 2 5 0 6 1 0.223 0.287 1.000 80 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(2), FDPS(4), IDI1(1), SQLE(2) 954797 9 8 9 2 8 1 0 0 0 0 0.468 0.296 1.000 81 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(2), B3GALT5(2), B3GNT5(3), FUT1(2), FUT2(3), ST3GAL3(1) 2071271 13 11 13 2 5 2 2 1 3 0 0.255 0.301 1.000 82 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(4), CREM(1), FHL5(1), FSHR(2), GNAS(6), XPO1(3) 2637517 17 16 17 3 7 1 4 2 3 0 0.391 0.338 1.000 83 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(2), GOT2(1), TAT(3), TYR(2) 1361490 8 8 8 2 4 0 3 0 1 0 0.515 0.343 1.000 84 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(3), ALAS2(2), FECH(1), PPOX(2), UROD(1), UROS(1) 2276029 10 9 10 1 4 0 4 0 2 0 0.201 0.416 1.000 85 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(1) 210091 1 1 1 0 1 0 0 0 0 0 0.701 0.425 1.000 86 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(1), CRK(1), DOCK1(4), ELK1(2), FOS(2), GAB1(2), HGF(5), HRAS(1), ITGA1(3), ITGB1(2), JUN(2), MAP2K1(2), MAP4K1(3), MAPK1(9), MAPK3(1), MAPK8(1), MET(2), PAK1(1), PIK3CA(58), PIK3R1(10), PTEN(17), PTK2(2), PTK2B(3), PXN(2), RAP1A(1), RAP1B(1), RASA1(4), SOS1(5), STAT3(2) 13239279 149 86 101 20 86 6 27 12 18 0 0.000365 0.425 1.000 87 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), LARS(3), LARS2(1), PDHA1(1), PDHA2(4), PDHB(2) 2917181 12 11 11 1 7 1 1 1 2 0 0.202 0.427 1.000 88 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(1), PSMB1(1), PSMB10(2), PSMB2(1), PSMB3(1), PSMB6(1), PSMB8(4), PSMB9(1) 2376232 12 11 12 2 3 1 5 0 3 0 0.408 0.457 1.000 89 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(2) 339223 2 1 2 0 0 1 1 0 0 0 0.597 0.476 1.000 90 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(5), CPT1A(4), LEP(1), LEPR(8), PRKAA2(3), PRKAG1(1), PRKAG2(2) 4213889 24 21 24 2 17 1 4 0 2 0 0.0508 0.511 1.000 91 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 DHRS1(1), DHRS3(2), DHRSX(4), HSD3B7(1), PON1(1), PON2(2), PON3(1), RDH13(1) 2601184 13 12 13 3 6 0 4 2 1 0 0.326 0.521 1.000 92 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(4), CD3D(2), CD4(1), CREBBP(15), GNAS(6), GNB1(1), GNGT1(1), HLA-DRA(1), HLA-DRB1(1), PRKAR2A(1), PTPRC(10), ZAP70(2) 6427096 45 38 44 8 21 3 9 2 9 1 0.0788 0.523 1.000 93 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(4), CD3D(2), CD4(1), CREBBP(15), GNAS(6), GNB1(1), GNGT1(1), HLA-DRA(1), HLA-DRB1(1), PRKAR2A(1), PTPRC(10), ZAP70(2) 6427096 45 38 44 8 21 3 9 2 9 1 0.0788 0.523 1.000 94 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), EHHADH(1), HADH(1), HSD17B10(1), HSD17B4(10), SIRT1(2), SIRT2(1), SIRT5(2), SIRT7(1), VNN2(2) 3473668 22 19 22 3 13 1 2 3 3 0 0.138 0.525 1.000 95 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(4), GABBR1(5), GPRC5B(2), GPRC5D(1), GRM1(3), GRM2(2), GRM3(2), GRM4(1), GRM5(5), GRM7(3), GRM8(6) 5678709 34 26 34 4 19 2 11 2 0 0 0.00396 0.537 1.000 96 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(2), HRAS(1), PTK2B(3), SOS1(5) 2545116 11 9 11 1 4 1 4 1 1 0 0.233 0.544 1.000 97 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 9 BAG4(1), BIRC3(1), CASP8(9), FADD(1), RIPK1(2), TNFRSF1A(4), TNFRSF1B(2), TRAF2(1) 2176855 21 17 20 5 7 2 2 2 8 0 0.434 0.557 1.000 98 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(2), DAG1(3), GNAQ(2), ITPKA(1), ITPKB(1) 1700826 9 9 9 2 5 0 3 1 0 0 0.405 0.560 1.000 99 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(2), CDK2(1), CUL1(4), RB1(9), TFDP1(2) 2550709 18 16 18 7 6 3 1 2 5 1 0.839 0.579 1.000 100 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 MAX(2), MYC(1), SP1(3), SP3(2), TP53(12), WT1(2) 1983094 22 16 21 4 15 2 4 0 1 0 0.254 0.607 1.000 101 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(2), ST3GAL1(2), ST3GAL2(1), ST3GAL5(2), ST6GALNAC2(2), ST8SIA1(2) 1648539 11 11 11 3 5 0 4 0 2 0 0.296 0.610 1.000 102 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(2), CALM3(1), CAMK1(2), CAMK2A(3), CAMK2B(1), CAMK2D(2), CAMK4(2), CAMKK1(1), CAMKK2(4), CREB1(2), SYT1(2) 3402213 22 19 22 4 13 1 6 2 0 0 0.168 0.615 1.000 103 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(1), AOC3(3), CES1(3), ESD(1) 1685080 8 7 8 1 4 0 2 2 0 0 0.257 0.637 1.000 104 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(3), HLCS(2) 918185 5 4 5 0 3 0 0 2 0 0 0.231 0.640 1.000 105 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 48 AKT1(3), AKT2(1), AKT3(3), BRD4(7), CAP1(1), CBL(1), CDC42(1), CDKN2A(4), F2RL2(1), FLOT2(2), GSK3A(3), INPPL1(4), IRS1(2), IRS4(2), LNPEP(1), MAPK1(9), MAPK3(1), PARD3(8), PARD6A(1), PDK1(3), PIK3CA(58), PIK3CD(1), PIK3R1(10), PTEN(17), PTPN1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), SERPINB6(1), SFN(1), SORBS1(5), SOS1(5), SOS2(5), YWHAE(2), YWHAQ(2), YWHAZ(3) 16608653 175 95 127 22 117 4 17 14 23 0 3.55e-05 0.643 1.000 106 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(2), HK1(2), HK2(4), HK3(1), PGM3(1) 2993197 10 10 10 1 5 1 2 0 2 0 0.165 0.644 1.000 107 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(5), ERBB4(4), NRG2(1), NRG3(3), PRKCA(3), PSEN1(4) 2647186 20 16 20 3 10 1 5 3 1 0 0.189 0.645 1.000 108 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(4), DIAPH1(1), FYN(3), GSN(2), HRAS(1), ITGA1(3), ITGB1(2), MAP2K1(2), MAPK1(9), MAPK3(1), MYLK(2), PIK3CA(58), PIK3R1(10), PTK2(2), PXN(2), ROCK1(3), TLN1(3) 11066761 108 76 63 14 72 3 18 9 6 0 0.00147 0.663 1.000 109 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD4(1), HLA-DRA(1), HLA-DRB1(1) 1017993 3 3 3 1 2 1 0 0 0 0 0.635 0.664 1.000 110 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(1), GNAQ(2), GNAS(6), GNB1(1), GNGT1(1), HRAS(1), LIMK1(4), MAP2K1(2), MAPK1(9), MAPK3(1), NOX1(2), PIK3C2G(5), PLCB1(10), PPP1R12B(3), PRKCA(3), PTK2(2), ROCK2(4) 7377922 57 41 51 6 38 1 11 4 3 0 0.00769 0.667 1.000 111 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(2), HK1(2), HK2(4), HK3(1), IMPA2(2), ISYNA1(1), PGM3(1) 3404056 13 12 13 1 8 1 2 0 2 0 0.0684 0.672 1.000 112 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(1) 443655 1 1 1 0 1 0 0 0 0 0 0.802 0.703 1.000 113 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(2), FDPS(4), IDI1(1), IDI2(2), SQLE(2) 1267791 11 9 11 3 9 1 0 1 0 0 0.549 0.708 1.000 114 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1B(2), ADH4(1), ADH6(1), ADH7(1), ADHFE1(1) 1631978 6 6 6 2 3 0 1 0 2 0 0.717 0.713 1.000 115 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(5), DLL1(1), FURIN(1), NOTCH1(14), PSEN1(4) 2699809 25 18 25 5 10 2 8 2 3 0 0.201 0.717 1.000 116 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CDK2(1), CUL1(4), RB1(9), RBX1(1), TFDP1(2) 2532219 17 15 17 7 7 3 1 1 4 1 0.869 0.734 1.000 117 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR1(3), MTMR2(1), MTMR6(1), PHPT1(1) 1873511 6 6 6 1 3 0 1 0 2 0 0.561 0.741 1.000 118 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 PLCG1(3), PRKCA(3), PTK2B(3) 1945685 9 9 9 2 6 0 2 0 1 0 0.382 0.760 1.000 119 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(1), CHRNA1(2) 944062 3 3 3 1 2 1 0 0 0 0 0.632 0.775 1.000 120 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(4), CDO1(2), CSAD(1), GAD1(4) 1682636 11 11 11 4 5 0 3 0 3 0 0.675 0.799 1.000 121 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(1), ADORA3(3), P2RY1(1) 1629688 5 5 5 1 3 1 0 0 1 0 0.219 0.800 1.000 122 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 SUCLA2(1) 634106 1 1 1 1 0 0 0 0 1 0 0.928 0.802 1.000 123 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(2), BMPR1A(1), BMPR1B(2), BMPR2(3) 1790461 8 8 8 2 3 1 2 1 1 0 0.615 0.802 1.000 124 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(2), ACAT2(1) 981353 3 3 3 0 1 1 0 1 0 0 0.454 0.805 1.000 125 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD3D(2), CD8A(2), ITGAL(4), PTPRC(10), THY1(1) 3080645 19 17 19 5 6 3 4 2 4 0 0.393 0.806 1.000 126 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), MIOX(1) 2462901 10 10 10 2 5 0 2 3 0 0 0.371 0.809 1.000 127 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(3), ATM(11), CCND1(1), CDK2(1), CDKN1A(1), MDM2(1), PCNA(1), RB1(9), TP53(12) 5301688 40 32 38 9 20 2 7 1 9 1 0.491 0.820 1.000 128 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(2), FH(1), MDH1(1), MDH2(1), SDHB(1), SUCLA2(1) 2621441 7 7 7 1 3 0 2 0 2 0 0.423 0.828 1.000 129 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(3), AKT2(1), AKT3(3), BAD(2), BCR(2), BLNK(2), BTK(4), CD19(1), DAG1(3), EPHB2(3), ITPKA(1), ITPKB(1), MAP2K1(2), MAPK1(9), NFAT5(5), NFKB1(2), NFKB2(1), NFKBIA(2), NFKBIE(2), PIK3CA(58), PIK3CD(1), PIK3R1(10), PLCG2(4), PPP1R13B(2), SERPINA4(2), SOS1(5), SOS2(5), SYK(1), VAV1(2) 15225620 139 85 92 20 88 4 25 12 10 0 0.000277 0.830 1.000 130 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(11), CDC25A(2), CDC25B(4), CDC25C(2), CDK2(1), CHEK1(1), MYT1(4), RB1(9), TP53(12) 5183705 46 32 44 8 29 2 7 0 7 1 0.237 0.832 1.000 131 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(2), ACP5(1), ACP6(1), ACPT(5), ALPI(3), ALPL(1), ALPP(2), ALPPL2(1), CYP3A43(2), CYP3A5(2), CYP3A7(1), DHRS1(1), DHRS3(2), DHRSX(4), PON1(1), PON2(2), PON3(1) 5269010 32 28 32 6 19 0 10 2 1 0 0.0730 0.834 1.000 132 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(2), NFKB1(2), NFKBIA(2), PLCB1(10), PRKCA(3), RELA(7) 2382147 26 18 26 5 18 1 2 3 2 0 0.275 0.838 1.000 133 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(2), AFMID(1), GRHPR(1), HAO1(2), HAO2(1), MDH1(1), MDH2(1), MTHFD1(1), MTHFD1L(2), MTHFD2(2) 3920475 14 14 14 2 8 0 3 1 2 0 0.205 0.843 1.000 134 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNG(1), IL12A(2), IL12B(2), IL15(2), IL16(2), IL1A(2), IL5(1), IL6(1), IL8(2) 2780996 15 14 15 4 8 2 3 0 2 0 0.496 0.848 1.000 135 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(3), POLD2(1), POLE(7), POLG(3), POLL(1), POLQ(13) 4877518 29 22 29 4 16 0 7 1 5 0 0.0684 0.858 1.000 136 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 ELK1(2), FOS(2), HRAS(1), IGF1R(3), IRS1(2), JUN(2), MAP2K1(2), MAPK3(1), MAPK8(1), PIK3CA(58), PIK3R1(10), RASA1(4), SOS1(5) 7172725 93 66 54 16 59 4 16 9 5 0 0.0251 0.863 1.000 137 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(2), UXS1(2) 1161121 4 4 4 1 3 0 0 0 1 0 0.678 0.867 1.000 138 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(4), CALM1(2), CALM3(1), ELK1(2), FCER1G(1), FOS(2), HRAS(1), JUN(2), MAP2K1(2), MAP2K7(1), MAP3K1(4), MAPK1(9), MAPK3(1), MAPK8(1), NFATC1(4), NFATC2(4), NFATC3(5), NFATC4(3), PAK2(1), PIK3CA(58), PIK3R1(10), PLA2G4A(3), PLCG1(3), PPP3CA(1), PPP3CC(1), SOS1(5), SYK(1), SYT1(2), VAV1(2) 12307175 136 82 91 21 91 5 21 12 7 0 0.00283 0.875 1.000 139 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(3), ARHGAP5(4), CASP1(1), CASP10(1), CASP3(1), CASP8(9), CASP9(1), GZMB(1), JUN(2), PRF1(1) 3721294 24 21 23 5 9 0 3 2 10 0 0.391 0.877 1.000 140 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(3), APC(7), AR(8), ASAH1(2), BRAF(2), CCL15(1), DAG1(3), EGFR(7), GNA11(2), GNA15(4), GNAI1(1), GNAQ(2), ITPKA(1), ITPKB(1), ITPR1(8), ITPR2(5), ITPR3(2), KCNJ5(1), KCNJ9(1), MAPK1(9), PHKA2(7), PIK3CA(58), PIK3CD(1), PIK3R1(10), PITX2(2), PTX3(1) 15686574 149 92 102 23 101 5 22 13 8 0 0.000227 0.878 1.000 141 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(2), DNAJC3(3), EIF2S1(3), EIF2S2(2), NFKB1(2), NFKBIA(2), RELA(7), TP53(12) 2940902 33 20 32 7 23 1 3 2 4 0 0.335 0.883 1.000 142 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(1), NR1H3(3), NR1H4(1), RXRA(1) 1548809 6 6 6 2 3 0 3 0 0 0 0.597 0.889 1.000 143 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(1), FMOD(1), KERA(1), LUM(1) 1059210 4 4 4 2 1 1 2 0 0 0 0.792 0.890 1.000 144 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(1), CYP2A13(1), CYP2A6(2), CYP2A7(5), NAT1(1), NAT2(1), XDH(2) 2348938 13 10 13 3 10 1 2 0 0 0 0.240 0.896 1.000 145 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2) 2305970 13 12 13 3 8 0 2 3 0 0 0.370 0.902 1.000 146 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2) 2305970 13 12 13 3 8 0 2 3 0 0 0.370 0.902 1.000 147 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(4), CR2(3), HLA-DRA(1), HLA-DRB1(1), ITGAL(4), PTPRC(10) 4333358 23 21 23 5 8 3 3 3 6 0 0.356 0.903 1.000 148 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD3D(2), CD4(1), CXCR3(1), IFNG(1), IL12A(2), IL12B(2), IL12RB1(1), IL12RB2(2), JAK2(6), STAT4(4), TYK2(9) 4372283 31 24 31 8 16 4 3 1 5 2 0.350 0.903 1.000 149 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(2), GRHPR(1), HAO1(2), HAO2(1), MDH1(1), MDH2(1), MTHFD1(1), MTHFD1L(2), MTHFD2(2) 3734683 13 13 13 2 8 0 3 0 2 0 0.241 0.907 1.000 150 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(2), UGP2(2), UXS1(2) 1465089 6 5 6 1 5 0 0 0 1 0 0.501 0.907 1.000 151 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD3D(2), CD4(1), ITGAL(4), PTPRC(10), THY1(1) 3278027 18 16 18 5 6 3 3 2 4 0 0.431 0.910 1.000 152 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 IFNG(1), IFNGR1(6), JAK1(1), JAK2(6), PTPRU(3), REG1A(2), STAT1(2) 3352189 21 20 20 5 11 1 1 1 6 1 0.419 0.914 1.000 153 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(3), PNPO(2) 1396942 5 3 5 1 3 0 1 0 1 0 0.569 0.927 1.000 154 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(2), CCNA2(2), CCND1(1), CDK2(1), CDKN2A(4), E2F2(1), E2F4(1), PRB1(1) 2577659 13 12 13 4 6 0 1 4 2 0 0.672 0.932 1.000 155 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 IFNG(1), IFNGR1(6), IFNGR2(3), IKBKB(2), JAK2(6), LIN7A(2), NFKB1(2), NFKBIA(2), RB1(9), RELA(7), TNFRSF1A(4), TNFRSF1B(2), TP53(12), USH1C(3), WT1(2) 5124976 63 38 61 10 28 8 8 2 15 2 0.0648 0.932 1.000 156 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(3), F13A1(2), F2R(1), FGA(6), FGG(1), PLAT(3), PLAU(1), PLG(1) 3941752 18 17 17 3 11 1 4 2 0 0 0.254 0.933 1.000 157 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(2), CREBBP(15), EP300(23), FADD(1), HDAC3(3), IKBKB(2), NFKB1(2), NFKBIA(2), RELA(7), RIPK1(2), TNFRSF1A(4), TNFRSF1B(2), TRAF6(1) 6359731 66 42 61 12 30 5 10 1 16 4 0.0858 0.934 1.000 158 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(11), CDC25A(2), CDC25B(4), CDC25C(2), CHEK1(1), MYT1(4) 4047880 24 18 23 3 18 0 4 0 2 0 0.186 0.939 1.000 159 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(3), ENO3(4), FARS2(1), GOT2(1), PAH(2), TAT(3), YARS(2) 2403206 16 11 16 5 10 0 2 2 2 0 0.586 0.939 1.000 160 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(4), GNAS(6), GNB1(1), GNGT1(1), PRKAA2(3), PRKAG1(1), PRKAG2(2), PRKAR2A(1) 4342256 19 19 19 3 12 0 5 1 1 0 0.197 0.941 1.000 161 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(1), ACTR2(1), ARPC1A(2), ARPC2(3), CDC42(1), RAC1(1), WASF1(3), WASL(4) 2391419 16 13 16 4 8 0 2 1 5 0 0.571 0.941 1.000 162 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 FLT3(3), IL11(1), IL1A(2), IL6(1), KITLG(1), TGFB2(1), TGFB3(2) 2482835 11 11 11 3 5 0 4 0 2 0 0.536 0.945 1.000 163 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(3), BAK1(1), BID(1), BIK(1), BIRC2(2), BIRC3(1), CASP3(1), CASP6(2), CASP8(9), CASP9(1), DFFA(1), DFFB(1) 3935645 24 21 23 6 6 1 6 3 8 0 0.522 0.946 1.000 164 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 MST1(2), MST1R(7) 1816693 9 7 9 5 5 1 0 0 3 0 0.931 0.946 1.000 165 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(3), ALAS2(2), CPO(1), FECH(1), GATA1(2), UROD(1), UROS(1) 2445839 11 10 11 3 5 1 5 0 0 0 0.494 0.950 1.000 166 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 FH(1), MDH1(1), OGDH(4), SDHA(4), SUCLA2(1) 2787841 11 11 11 3 5 0 4 0 2 0 0.535 0.951 1.000 167 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(1), GAD1(4), HDC(2), TH(2), TPH1(2) 1736308 11 9 11 4 7 1 2 0 1 0 0.620 0.952 1.000 168 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(2), FOS(2), HRAS(1), JUN(2), MAP2K1(2), MAPK1(9), MAPK3(1), MYC(1), NFKB1(2), NFKBIA(2), PLCB1(10), PRKCA(3), RELA(7) 4389778 44 33 38 9 32 1 5 2 4 0 0.126 0.952 1.000 169 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(4), ADRB2(2), CFTR(4), GNAS(6), PRKAR2A(1) 3648375 17 15 17 4 8 0 4 1 4 0 0.411 0.953 1.000 170 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(2), SEC61A2(2), SRP19(2), SRP68(2), SRP72(2) 2187922 10 9 10 3 5 0 2 2 1 0 0.658 0.953 1.000 171 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 HLA-DRA(1), HLA-DRB1(1), IFNG(1), IFNGR1(6), IFNGR2(3), IL12A(2), IL12B(2), IL12RB1(1), IL12RB2(2), IL18R1(2), IL4R(5) 3582955 26 24 25 7 12 5 3 0 6 0 0.577 0.953 1.000 172 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(1), ADCY1(4), CAP1(1), CDC25C(2), GNAI1(1), GNAS(6), GNB1(1), GNGT1(1), HRAS(1), MAPK1(9), MAPK3(1), MYT1(4), PIN1(1), PRKAR2A(1), RPS6KA1(1) 5883965 35 30 29 6 22 0 9 2 2 0 0.0824 0.956 1.000 173 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 ELK1(2), FOS(2), HRAS(1), JAK1(1), JUN(2), MAP2K1(2), MAP3K1(4), MAPK3(1), MAPK8(1), PDGFRA(2), PIK3CA(58), PIK3R1(10), PLCG1(3), PRKCA(3), RASA1(4), SOS1(5), STAT1(2), STAT3(2), STAT5A(2) 10182880 107 71 68 18 68 3 20 10 6 0 0.00982 0.958 1.000 174 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 11 CHST11(2), CHST12(2), PAPSS1(1), PAPSS2(2), SULT1A1(1), SULT1E1(1), SULT2B1(3), SUOX(3) 2487026 15 11 15 4 9 0 2 3 1 0 0.462 0.959 1.000 175 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), B4GALT7(1), HS3ST2(1), HS3ST3A1(2), HS3ST3B1(1), XYLT2(1) 1793874 7 7 7 6 2 0 3 0 2 0 0.924 0.959 1.000 176 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), B4GALT7(1), HS3ST2(1), HS3ST3A1(2), HS3ST3B1(1), XYLT2(1) 1793874 7 7 7 6 2 0 3 0 2 0 0.924 0.959 1.000 177 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(1), GABRA2(2), GABRA4(1), GABRA5(1), GABRA6(1), PRKCE(1) 2284662 7 7 7 2 3 1 1 0 2 0 0.595 0.960 1.000 178 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(1), RAB5A(1), RAB6A(1) 1257886 3 3 3 2 1 0 1 0 1 0 0.922 0.962 1.000 179 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP2(6) 2476653 7 6 7 0 5 1 0 0 1 0 0.308 0.964 1.000 180 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(3), ACO1(2), ACSS1(3), ACSS2(2), FH(1), MDH1(1), MDH2(1), SUCLA2(1) 3883753 14 13 14 3 8 0 4 0 2 0 0.315 0.967 1.000 181 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 SHMT1(2), SHMT2(1) 1256499 3 3 3 4 2 0 0 0 1 0 0.975 0.970 1.000 182 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(1), DHRS3(2), DHRSX(4), ESCO1(1), ESCO2(1), NAT6(1), PNPLA3(1), SH3GLB1(2) 4731422 13 12 13 2 7 0 3 2 1 0 0.331 0.970 1.000 183 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 16 ADAM10(2), ANKRD1(1), CYR61(1), IFNG(1), IL1A(2), IL1R1(2), MYOG(1) 3113649 10 10 10 2 6 0 1 2 1 0 0.447 0.970 1.000 184 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 21 CCNA1(2), CCND1(1), CDC25A(2), CDK2(1), CDKN1A(1), CDKN2A(4), RB1(9), RBL1(3), TFDP1(2) 4537972 25 19 25 8 8 4 4 3 5 1 0.731 0.971 1.000 185 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA2(1), IL4R(5), JAK1(1), JAK2(6), TYK2(9) 3054141 22 17 22 7 10 2 5 1 2 2 0.601 0.972 1.000 186 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA2(1), IL4R(5), JAK1(1), JAK2(6), TYK2(9) 3054141 22 17 22 7 10 2 5 1 2 2 0.601 0.972 1.000 187 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(3), BAD(2), BAK1(1), BCL2L11(3), BID(1), CASP9(1), CES1(3) 3356348 14 13 14 4 3 0 4 2 5 0 0.787 0.973 1.000 188 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), BCAT2(2), IARS2(3), LARS(3), LARS2(1), PDHA1(1), PDHA2(4), PDHB(2), VARS(2), VARS2(1) 4708158 20 18 19 4 12 1 2 1 4 0 0.324 0.973 1.000 189 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(1), MMP2(6), MMP9(1), RECK(3), TIMP1(1), TIMP2(1) 2225502 13 10 13 3 7 2 3 1 0 0 0.359 0.974 1.000 190 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(3), BIRC2(2), BIRC3(1), CASP10(1), CASP3(1), CASP8(9), CASP9(1), DFFA(1), DFFB(1), GZMB(1), PRF1(1), SCAP(1), SREBF1(3), SREBF2(2) 5285928 28 25 27 6 10 1 5 2 10 0 0.223 0.974 1.000 191 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADM(4), ACADS(3), ACAT1(2) 1560843 9 5 9 3 4 1 2 1 1 0 0.736 0.975 1.000 192 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 EPHX2(2), HSD3B7(1), RDH13(1) 1384183 4 4 4 2 3 0 1 0 0 0 0.733 0.976 1.000 193 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(1), ITPKA(1), PDE1A(3), PDE1B(2), PLCB1(10), PLCB2(2), PRL(3), TRH(2), VIP(2) 3195227 26 22 26 7 15 2 4 2 3 0 0.436 0.977 1.000 194 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(1), ACOX3(2), PLA2G12A(1), PLA2G12B(3), PLA2G2D(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2) 3060281 14 10 14 2 9 0 3 1 1 0 0.141 0.978 1.000 195 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(3), BLVRA(1), CP(2), EPRS(7), FECH(1), GUSB(4), HMOX1(2), PPOX(2), UGT1A1(2), UGT1A4(1), UGT1A5(1), UGT1A6(1), UGT2B15(5), UGT2B4(1), UROD(1), UROS(1) 7953409 35 25 35 5 24 0 4 3 4 0 0.0480 0.979 1.000 196 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1), BCKDK(1), CBS(1) 1424653 3 3 3 3 1 0 1 0 1 0 0.973 0.979 1.000 197 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3D(2), IFNG(1), TGFB2(1), TGFB3(2), TGFBR1(1), TGFBR2(5), TOB2(2) 3116087 14 12 14 7 6 1 2 1 4 0 0.921 0.979 1.000 198 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(1), EGFR(7), ERBB3(12), NRG1(1), UBE2D1(1) 2959798 22 18 19 5 11 1 7 2 1 0 0.399 0.979 1.000 199 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT3(1), B4GALT5(1), FUT8(3), ST3GAL1(2), ST3GAL2(1), ST3GAL3(1) 2275445 9 8 9 5 4 0 2 0 3 0 0.863 0.980 1.000 200 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(3), MDH1(1), ME1(1), PC(1), PDHA1(1), SLC25A1(1), SLC25A11(1) 2711819 9 9 9 3 4 1 3 0 1 0 0.609 0.981 1.000 201 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(1), AKT1(3), DAG1(3), DGKA(3), ITGA9(2), ITPKA(1), ITPKB(1), ITPR1(8), ITPR2(5), ITPR3(2), MAP2K1(2), MAPK1(9), MAPK3(1), PAK1(1), PDE3A(5), PIK3C2G(5), PIK3CA(58), PIK3CD(1), PIK3R1(10), RPS4X(2), VASP(1) 14438587 124 83 78 21 87 3 18 9 7 0 0.00182 0.984 1.000 202 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(3), CABIN1(5), CALM1(2), CALM3(1), CAMK1(2), HDAC5(2), IGF1R(3), INSR(4), MAPK7(2), MEF2A(1), MEF2B(1), MEF2C(1), MEF2D(3), NFATC1(4), NFATC2(4), PIK3CA(58), PIK3R1(10), PPP3CA(1), PPP3CC(1), SYT1(2) 10036328 110 74 70 21 74 8 13 11 4 0 0.0111 0.984 1.000 203 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(4), ABCB11(4), ABCB4(5), ABCC1(1), ABCC3(9) 4241904 23 17 23 6 11 0 7 1 4 0 0.275 0.986 1.000 204 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(2), FUT2(3), FUT6(1), ST3GAL3(1) 1459781 7 5 7 4 2 1 1 2 1 0 0.877 0.987 1.000 205 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(2), ACAT2(1), BDH1(1), HMGCS1(1) 2078101 5 4 5 1 3 1 0 1 0 0 0.562 0.988 1.000 206 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD3D(2), CD4(1) 948017 3 2 3 2 1 1 1 0 0 0 0.837 0.989 1.000 207 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2R(1), F2RL3(2), GNAI1(1), GNB1(1), GNGT1(1), HRAS(1), ITGA1(3), ITGB1(2), MAP2K1(2), MAPK1(9), MAPK3(1), PLA2G4A(3), PLCB1(10), PRKCA(3), PTK2(2), SYK(1) 7077780 43 32 37 6 29 1 9 3 1 0 0.0317 0.989 1.000 208 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(1), PARK2(2), SNCAIP(4), UBE2L6(1) 1841570 8 8 8 3 3 0 2 1 2 0 0.774 0.991 1.000 209 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(1), IL8(2), NFKB1(2), NOX1(2), RELA(7), XDH(2) 2836983 16 11 16 5 6 2 4 1 3 0 0.631 0.991 1.000 210 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1B(2), ADH4(1), ADH6(1), ADH7(1), ADHFE1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2) 3868886 15 15 15 4 8 0 2 3 2 0 0.451 0.991 1.000 211 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(2), PLCD1(2), PRKCA(3) 1435438 7 7 7 4 5 0 1 0 1 0 0.764 0.991 1.000 212 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(1), CYP2E1(1), PTGS2(2) 1538025 4 4 4 3 3 0 0 0 1 0 0.878 0.991 1.000 213 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(1), GOT2(1), PAH(2), TAT(3), YARS(2), YARS2(1) 2538190 10 8 10 3 6 0 2 1 1 0 0.610 0.992 1.000 214 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(1), GABARAP(1), GABRA1(1), GABRA2(2), GABRA4(1), GABRA5(1), GABRA6(1), NSF(1), UBQLN1(4) 3500288 13 13 13 3 7 2 1 0 3 0 0.408 0.992 1.000 215 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 SHMT1(2), SHMT2(1) 1662499 3 3 3 4 2 0 0 0 1 0 0.982 0.992 1.000 216 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(3), GLUD1(2), PRODH(1) 1661272 6 6 6 5 4 0 1 0 1 0 0.974 0.992 1.000 217 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(1), DHRS1(1), DHRS3(2), DHRSX(4), HEMK1(1), LCMT1(4), LCMT2(1), METTL2B(1), PRMT2(1), PRMT5(1), PRMT6(1), PRMT7(3) 4294210 21 18 21 5 11 1 5 1 3 0 0.286 0.993 1.000 218 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 17 ABCB1(4), AKT1(3), ATM(11), CDKN1A(1), CPB2(3), CSNK1D(2), HIF1A(5), MAPK8(1), MDM2(1), NQO1(1), TP53(12) 5765618 44 31 41 6 30 1 8 2 3 0 0.0917 0.993 1.000 219 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(1), CD8A(2), IL11(1), IL5(1), IL6(1), IL8(2) 1800708 8 7 8 5 3 2 2 0 1 0 0.901 0.993 1.000 220 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), LDLR(1), MBTPS1(3), SCAP(1), SREBF1(3), SREBF2(2) 3465430 11 9 11 3 7 0 2 0 2 0 0.392 0.993 1.000 221 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6(1), IL6R(3), JAK1(1), JAK2(6), JAK3(4), PIAS3(2), PTPRU(3), REG1A(2), STAT3(2) 4458683 24 19 23 7 13 1 4 1 4 1 0.394 0.993 1.000 222 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), EHHADH(1), SDS(1) 1432488 3 3 3 2 2 0 0 0 1 0 0.861 0.994 1.000 223 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(3), CDKN1A(1), EPOR(1), HIF1A(5), JAK2(6), NFKB1(2), NFKBIA(2), RELA(7) 3795591 27 19 27 7 15 2 4 1 4 1 0.524 0.994 1.000 224 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), SHMT1(2) 4464638 16 15 16 5 3 0 5 1 7 0 0.536 0.994 1.000 225 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), SHMT1(2) 4464638 16 15 16 5 3 0 5 1 7 0 0.536 0.994 1.000 226 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), SHMT1(2) 4464638 16 15 16 5 3 0 5 1 7 0 0.536 0.994 1.000 227 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 CCND1(1), CDK2(1), CDKN1A(1), CDKN2A(4), E2F2(1), MDM2(1), NXT1(1), PRB1(1), TP53(12) 2380854 23 18 22 7 14 0 5 3 1 0 0.549 0.995 1.000 228 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(11), ATR(6), CDC25C(2), CHEK1(1), CHEK2(1), TP53(12) 4624531 33 24 31 5 25 0 4 1 3 0 0.263 0.995 1.000 229 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(1), CD36(2), FOS(2), FYN(3), JUN(2), THBS1(2) 2102412 12 9 12 4 8 1 2 0 1 0 0.696 0.995 1.000 230 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA2(1), ADH1B(2), ADH4(1), ADH6(1), ADH7(1), ADHFE1(1), AKR1C4(2), AKR1D1(2), ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), BAAT(4), CEL(3), CYP27A1(3), CYP7A1(2), SOAT2(2) 6750067 38 28 38 9 20 2 9 3 4 0 0.207 0.995 1.000 231 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 NDUFA1(1), SDHA(4), SDHB(1), SDHD(1), UQCRC1(1) 1888486 8 7 8 5 4 1 2 0 1 0 0.946 0.996 1.000 232 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(3), BIRC2(2), BIRC3(1), CASP1(1), CASP10(1), CASP2(2), CASP3(1), CASP6(2), CASP8(9), CASP9(1), DFFA(1), DFFB(1), GZMB(1), LMNB1(1), PRF1(1) 5602653 28 26 27 7 11 1 4 3 9 0 0.527 0.996 1.000 233 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 CAPN1(5), CAPNS1(1), CDK5R1(1), CSNK1D(2), MAPT(2) 2738707 11 9 11 4 5 2 3 0 1 0 0.680 0.996 1.000 234 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(4), ARHGEF1(1), GNA12(2), GNA13(3), GNAQ(2), GNB1(1), GNGT1(1), MYLK(2), PLCB1(10), PPP1R12B(3), PRKCA(3), ROCK1(3) 6054489 35 27 35 6 22 0 4 3 6 0 0.173 0.996 1.000 235 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXTL1(2), EXTL3(1), HS2ST1(1), HS3ST2(1), HS3ST3A1(2), HS3ST3B1(1), HS3ST5(1), HS6ST2(5), NDST2(4), NDST3(5), NDST4(4) 5974807 27 22 27 6 12 0 8 4 3 0 0.184 0.996 1.000 236 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP1(2), INPP4A(3), INPP4B(4), INPPL1(4), ITPKA(1), ITPKB(1), MIOX(1), OCRL(3), PIK3C2A(4), PIK3C2B(4), PIK3C2G(5), PIK3CA(58), PIK3CB(2), PIK3CG(1), PLCB1(10), PLCB2(2), PLCB3(2), PLCB4(1), PLCD1(2), PLCG1(3), PLCG2(4) 13071981 117 75 78 21 79 4 18 11 5 0 0.00666 0.997 1.000 237 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(2), FOSL2(2), IFNAR1(3), IFNAR2(2), MAPK8(1), NFKB1(2), RELA(7), TNFSF11(1), TRAF6(1) 3130743 21 14 21 5 13 1 3 1 3 0 0.549 0.997 1.000 238 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(15), DAXX(2), HRAS(1), PAX3(2), PML(6), RB1(9), SIRT1(2), SP100(7), TNFRSF1A(4), TNFRSF1B(2), TP53(12) 5346434 62 36 60 13 31 4 11 2 12 2 0.193 0.997 1.000 239 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(2), CHAT(2), DBH(1), DDC(2), GAD1(4), HDC(2), MAOA(1), PAH(2), SLC18A3(1), TH(2), TPH1(2) 4159064 21 18 21 6 10 1 6 1 3 0 0.440 0.997 1.000 240 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), FDXR(1), SHMT1(2) 4713736 17 16 17 5 3 0 6 1 7 0 0.479 0.997 1.000 241 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSS(1), HPRT1(1), IMPDH1(2), MTHFD2(2), OAZ1(2), POLB(1), POLD1(3), POLG(3), PRPS2(2), RRM1(2), SRM(1) 3701318 20 18 20 5 11 1 5 1 2 0 0.393 0.997 1.000 242 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(3), ALPL(1), ALPP(2), ALPPL2(1), GGH(2) 1858101 9 8 9 4 6 0 3 0 0 0 0.655 0.997 1.000 243 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), AKR1D1(2), CYP11A1(3), CYP11B1(1), CYP11B2(3), CYP17A1(2), CYP21A2(1), HSD11B2(1), HSD3B1(2), HSD3B2(1) 2774316 18 16 18 7 7 1 7 1 2 0 0.554 0.998 1.000 244 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), AKR1D1(2), CYP11A1(3), CYP11B1(1), CYP11B2(3), CYP17A1(2), CYP21A2(1), HSD11B2(1), HSD3B1(2), HSD3B2(1) 2774316 18 16 18 7 7 1 7 1 2 0 0.554 0.998 1.000 245 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(1), HLA-DRA(1), HLA-DRB1(1), IFNG(1), IL11(1), IL12A(2), IL12B(2), IL15(2), IL1A(2), IL5(1), IL6(1), IL8(2), TGFB2(1), TGFB3(2) 3733306 20 18 20 9 12 3 2 0 3 0 0.793 0.998 1.000 246 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CDC25A(2), CDC25B(4), CDC25C(2), XPO1(3) 2499885 11 8 11 3 8 0 1 1 1 0 0.688 0.998 1.000 247 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(1), ACTR2(1), ARPC1A(2), ARPC2(3), NCK1(2), NCKAP1(3), PIR(1), RAC1(1), WASF1(3), WASF2(2), WASF3(1), WASL(4) 4496973 24 21 24 5 10 0 6 2 6 0 0.391 0.998 1.000 248 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(1), JAK2(6), JAK3(4), PIAS3(2), PTPRU(3), REG1A(2) 4039984 18 17 17 5 9 1 3 1 3 1 0.470 0.998 1.000 249 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 PAPSS1(1), PAPSS2(2), SULT1E1(1), SUOX(3) 1770139 7 5 7 3 3 0 1 2 1 0 0.824 0.998 1.000 250 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(1), ENO1(3), GPI(3), HK1(2), PGAM1(1), PGK1(1), PKLR(3) 2695803 14 13 14 6 6 0 5 1 2 0 0.682 0.998 1.000 251 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 20 BAD(2), CASP8(9), FADD(1), MAP2K1(2), MAP3K1(4), MAPK1(9), MAPK3(1), MAPK8(1), NFKB1(2), NSMAF(4), RELA(7), RIPK1(2), SMPD1(3), TNFRSF1A(4), TRAF2(1) 5825668 52 37 45 10 24 3 10 4 11 0 0.125 0.998 1.000 252 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(2), HDAC9(3), MEF2A(1), MEF2B(1), MEF2C(1), MEF2D(3) 2396575 11 9 11 4 5 2 0 2 2 0 0.837 0.998 1.000 253 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 FDFT1(2), FDPS(4), HMGCR(1), IDI1(1), LSS(2), MVD(1), MVK(1), NQO1(1), PMVK(1), SQLE(2), VKORC1(1) 3231823 17 14 17 5 11 1 0 2 3 0 0.439 0.999 1.000 254 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(9), GNA12(2), PRKAG1(1), PRKAR2A(1) 2904144 13 11 13 5 10 0 0 1 2 0 0.809 0.999 1.000 255 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(2), ACAT2(1), EHHADH(1), GCDH(2), SDHB(1), SDS(1) 2296233 8 8 8 3 3 1 2 1 1 0 0.717 0.999 1.000 256 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(3), ALAS2(2), BLVRA(1), COX10(1), CP(2), EPRS(7), FECH(1), GUSB(4), HMOX1(2), MMAB(1), PPOX(2), UGT1A1(2), UGT1A4(1), UGT1A5(1), UGT1A6(1), UGT2A1(2), UGT2A3(3), UGT2B10(3), UGT2B11(3), UGT2B15(5), UGT2B17(3), UGT2B4(1), UGT2B7(1), UROD(1), UROS(1) 12336219 54 40 54 9 35 0 7 7 5 0 0.0396 0.999 1.000 257 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(2), ACP5(1), ACPT(5), ENPP1(2), ENPP3(5), FLAD1(3), TYR(2) 2864807 20 18 20 7 10 0 6 2 2 0 0.699 0.999 1.000 258 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(2), CALM3(1), CXCR4(3), FOS(2), GNAQ(2), JUN(2), MAPK8(1), PLCG1(3), PRKCA(3), PTK2B(3), SYT1(2) 3949464 24 21 24 7 14 1 4 2 3 0 0.425 0.999 1.000 259 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADM(4), ACADS(3), ACADVL(2), ACSL1(1), ACSL3(2), ACSL4(5), CPT1A(4), CPT2(1), EHHADH(1), SCP2(1) 4871776 24 16 24 7 12 2 3 0 7 0 0.512 0.999 1.000 260 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(1), ACAT1(2), ACAT2(1), EHHADH(1), SDS(1) 2460774 6 5 6 2 2 1 0 1 2 0 0.674 0.999 1.000 261 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(2), ACP5(1), ACP6(1), ACPT(5), ENPP1(2), ENPP3(5), FLAD1(3), MTMR1(3), MTMR2(1), MTMR6(1), PHPT1(1), TYR(2) 4416450 27 25 27 7 14 0 7 2 4 0 0.486 0.999 1.000 262 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(2), IL6(1), LDLR(1), LPL(2) 1527206 6 6 6 3 3 0 2 1 0 0 0.845 0.999 1.000 263 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(4), CASP1(1), CASP3(1), CASP8(9), GAPDH(1), INSR(4), ITCH(2), MAGI1(3), MAGI2(3), RERE(4), WWP2(4) 6861152 36 29 35 9 15 1 8 3 9 0 0.441 0.999 1.000 264 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(3), CTSD(1), ESR1(1), GREB1(3), HSPB1(1), MTA1(2), PDZK1(1), TUBA8(2) 3123710 14 12 14 5 9 1 2 1 1 0 0.525 0.999 1.000 265 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT1(2), FUT2(3), FUT9(3), GLA(1), HEXB(2), ST3GAL1(2), ST3GAL2(1), ST8SIA1(2) 2878006 16 13 16 7 4 2 7 1 2 0 0.702 0.999 1.000 266 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(1), AGT(2), AGTR1(1), NOS3(6), REN(1) 2924561 11 9 11 9 5 1 3 0 2 0 0.965 0.999 1.000 267 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(3), BST1(4), ENPP1(2), ENPP3(5), NADK(3), NADSYN1(5), NMNAT3(1), NNMT(1), NNT(1), NT5C(2), NT5C1A(2), NT5C1B(2), NT5C2(3), NT5E(1), NUDT12(2), QPRT(1) 6240129 38 26 38 8 18 1 10 5 4 0 0.204 0.999 1.000 268 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 13 CHUK(2), DUSP1(1), IKBKAP(3), IKBKB(2), MAP3K1(4), NFKB1(2), NFKBIA(2), RELA(7), TNFAIP3(2), TRAF3(3), TRAF6(1) 5403394 29 20 28 7 17 1 6 2 3 0 0.459 1.000 1.000 269 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(3), ENPP1(2), ENPP3(5), NADSYN1(5), NNMT(1), NNT(1), NT5C(2), NT5E(1), QPRT(1) 4201389 21 17 21 8 8 0 6 3 4 0 0.762 1.000 1.000 270 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 B3GALNT1(1), B3GALT5(2), FUT1(2), FUT2(3), FUT9(3), GLA(1), HEXB(2), ST3GAL1(2), ST3GAL2(1), ST8SIA1(2) 3054207 19 14 19 7 5 4 7 1 2 0 0.575 1.000 1.000 271 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(3), ASAH1(2), BRAF(2), CREB1(2), CREB3(1), CREB5(5), CREBBP(15), DAG1(3), EGR1(3), EGR3(1), EGR4(1), ELK1(2), FRS2(2), GNAQ(2), JUN(2), MAP1B(8), MAP2K7(1), MAPK1(9), MAPK3(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(2), MAPK9(4), PIK3C2G(5), PIK3CA(58), PIK3CD(1), PIK3R1(10), RPS6KA3(2), TH(2) 15060445 152 90 105 28 96 4 30 10 11 1 0.00543 1.000 1.000 272 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 EGF(1), EGFR(7), ELK1(2), FOS(2), HRAS(1), JAK1(1), JUN(2), MAP2K1(2), MAP3K1(4), MAPK3(1), MAPK8(1), PIK3CA(58), PIK3R1(10), PLCG1(3), PRKCA(3), RASA1(4), SOS1(5), STAT1(2), STAT3(2), STAT5A(2) 10901701 113 73 74 22 71 3 22 10 7 0 0.0373 1.000 1.000 273 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(6), C5(3), C6(5), C7(3), C9(1) 3721766 18 13 18 5 10 2 3 1 2 0 0.637 1.000 1.000 274 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT3(1), B3GNT5(3), B4GALT3(1), B4GALT4(1), FUT1(2), FUT2(3), FUT6(1), FUT9(3), GCNT2(3), ST3GAL6(1), ST8SIA1(2) 4588929 21 18 21 9 9 2 4 2 4 0 0.763 1.000 1.000 275 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1R(1), C1S(1), C2(1), C3(6), C5(3), C6(5), C7(3), C9(1) 4960906 21 15 21 5 11 3 4 1 2 0 0.459 1.000 1.000 276 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(2), ITGAL(4), ITGAM(4), SELE(1), SELL(1) 3167855 12 11 12 6 6 1 3 0 2 0 0.798 1.000 1.000 277 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(3), EGF(1), EGFR(7), HGS(2), RAB5A(1) 3737155 14 11 14 7 7 0 4 1 2 0 0.932 1.000 1.000 278 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(3), AASS(2) 2023037 5 5 5 2 5 0 0 0 0 0 0.842 1.000 1.000 279 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(2), GNAS(6), GNB1(1), GNGT1(1), PRKAR2A(1), PRKCA(3) 2743177 14 11 14 4 10 0 3 1 0 0 0.575 1.000 1.000 280 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(2), ITGA4(6), ITGAL(4), ITGB1(2), SELE(1), SELL(1) 3608559 16 15 16 8 8 2 4 0 2 0 0.902 1.000 1.000 281 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 52 ACTA1(1), AGT(2), AKT1(3), CALM1(2), CALM3(1), CALR(3), CAMK1(2), CAMK4(2), CREBBP(15), EDN1(1), FGF2(1), HRAS(1), MAP2K1(2), MAPK1(9), MAPK3(1), MAPK8(1), MEF2C(1), MYH2(9), NFATC1(4), NFATC2(4), NFATC3(5), NFATC4(3), NPPA(1), PIK3CA(58), PIK3R1(10), PPP3CA(1), PPP3CC(1), PRKAR2A(1), RPS6KB1(1), SYT1(2) 14571833 148 86 101 27 100 6 23 10 8 1 0.00459 1.000 1.000 282 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(1), APAF1(3), CASP3(1), CASP9(1), DAXX(2), FAS(5), FASLG(1), HSPB1(1), IL1A(2), MAPKAPK2(2), MAPKAPK3(1) 3182126 20 16 19 7 13 0 5 0 2 0 0.671 1.000 1.000 283 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(2), CDC25B(4), CDC25C(2), PRKCA(3), PTPRA(2) 2702582 13 8 13 3 13 0 0 0 0 0 0.337 1.000 1.000 284 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(1), F11(1), F12(1), F13B(2), F5(7), F7(2), F8(9), F9(3), FGA(6), FGG(1), LPA(2), PLAT(3), PLAU(1), PLG(1), SERPINF2(1), VWF(6) 10237278 47 29 46 7 18 4 14 5 5 1 0.0695 1.000 1.000 285 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CYB5R3(1), GCK(2), GFPT1(3), GNE(3), HEXB(2), HK1(2), HK2(4), HK3(1), PGM3(1), UAP1(2) 5027079 21 21 21 6 11 2 4 1 3 0 0.452 1.000 1.000 286 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(2), CDC25B(4), CDKN1A(1), CHEK1(1), NEK1(2) 2188379 10 7 10 3 9 0 1 0 0 0 0.803 1.000 1.000 287 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(5), CALM1(2), CALM3(1), CAPNS1(1), EP300(23), MEF2D(3), NFATC1(4), NFATC2(4), PPP3CA(1), PPP3CC(1), PRKCA(3), SYT1(2) 6905873 50 37 46 11 29 5 4 0 9 3 0.210 1.000 1.000 288 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B4GALT3(1), B4GALT4(1), CHST4(2), FUT8(3), ST3GAL1(2), ST3GAL2(1), ST3GAL3(1) 3396497 11 9 11 8 7 0 2 0 2 0 0.939 1.000 1.000 289 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 GOSR2(1), SNAP23(2), STX11(3), STX2(1), STX3(2), STX5(1), STX6(1), STX7(1), STX8(2), TSNARE1(1), VAMP5(2) 4900074 17 14 17 8 8 0 3 2 4 0 0.867 1.000 1.000 290 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(2), EIF2B5(1), EIF2S1(3), EIF2S2(2), EIF5(1) 3303132 9 7 9 3 8 0 0 0 1 0 0.773 1.000 1.000 291 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(3), FTCD(3), GART(1), MTHFD1(1), MTHFD1L(2), MTHFD2(2), MTHFR(4), MTR(2), SHMT1(2), SHMT2(1) 5537882 21 20 21 8 9 1 5 2 4 0 0.783 1.000 1.000 292 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(2), CYSLTR2(1), GPR161(1), GPR171(1), GPR18(1), GPR34(1), GPR39(2), GPR45(2), GPR65(1), GPR68(1), GPR75(1) 2880915 14 12 14 7 5 0 6 2 1 0 0.706 1.000 1.000 293 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 UBE2D1(1), UBE2E1(2), UBE2H(1), UBE2I(1), UBE2J2(2), UBE2L6(1), UBE3A(3) 3058751 11 11 11 4 8 1 1 0 1 0 0.762 1.000 1.000 294 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMB1(1), PSMB2(1), PSMB3(1), PSMB6(1), PSMC3(1), RPN1(2), UBE3A(3) 3832228 11 11 11 4 5 2 2 0 2 0 0.756 1.000 1.000 295 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(2), FOS(2), HRAS(1), IL3RA(2), JAK2(6), MAP2K1(2), MAPK3(1), SOS1(5), STAT5A(2), STAT5B(1) 5202063 24 18 24 7 11 2 6 2 2 1 0.496 1.000 1.000 296 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(2), ITGA4(6), ITGAL(4), ITGAM(4), ITGB1(2), SELE(1), SELL(1) 4778895 20 19 20 8 11 2 4 0 3 0 0.760 1.000 1.000 297 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5R1(1), FYN(3), LRP8(1), RELN(7), VLDLR(3) 4059547 15 13 15 8 8 0 4 1 2 0 0.945 1.000 1.000 298 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG3(2), ATG5(1), ATG7(1), BECN1(1), GABARAP(1), GABARAPL1(1), IFNA10(1), IFNA4(1), IFNA5(1), IFNA6(1), IFNA8(1), IFNG(1), PIK3C3(4), PIK3R4(2), PRKAA2(3), ULK1(2), ULK2(3) 6260292 28 23 28 7 16 1 5 2 4 0 0.398 1.000 1.000 299 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(2), CREM(1), FOS(2), JUN(2), MAPK3(1), POLR2A(5), PRKAR2A(1) 3734903 14 14 14 8 8 0 3 1 2 0 0.937 1.000 1.000 300 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(2), FH(1), IDH3A(2), IDH3B(1), IDH3G(1), MDH1(1), MDH2(1), PC(1), SDHA(4), SDHB(1), SUCLA2(1), SUCLG1(1), SUCLG2(1) 6074390 18 17 18 5 9 0 4 0 5 0 0.457 1.000 1.000 301 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 FDFT1(2), FDPS(4), HMGCR(1), HMGCS1(1), IDI1(1), LSS(2), MVD(1), MVK(1), NSDHL(2), PMVK(1), SQLE(2) 3870919 18 15 18 6 11 1 1 2 3 0 0.575 1.000 1.000 302 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM1(2), CALM3(1), CD3D(2), ELK1(2), FOS(2), FYN(3), HRAS(1), JUN(2), LAT(1), MAP2K1(2), MAP3K1(4), MAPK3(1), MAPK8(1), NFATC1(4), NFATC2(4), NFATC3(5), NFATC4(3), NFKB1(2), NFKBIA(2), PIK3CA(58), PIK3R1(10), PLCG1(3), PPP3CA(1), PPP3CC(1), PRKCA(3), RAC1(1), RASA1(4), RELA(7), SOS1(5), SYT1(2), VAV1(2), ZAP70(2) 13748761 143 79 104 25 91 7 26 11 8 0 0.00827 1.000 1.000 303 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(1), CD5(1), IFNG(1), IL12A(2), IL12B(2), IL5(1), ITGAX(3), TLR2(2), TLR4(2), TLR7(4), TLR9(2) 5444005 21 17 21 7 12 2 2 3 2 0 0.510 1.000 1.000 304 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX1(1), ACOX3(2), ELOVL2(1), ELOVL5(1), FADS1(2), FASN(4), HSD17B12(1) 4285006 12 10 12 6 7 0 2 1 2 0 0.715 1.000 1.000 305 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP3(1), DFFA(1), DFFB(1), GZMB(1), HMGB1(1), HMGB2(1), TOP2A(2), TOP2B(2) 3006185 10 8 10 4 7 2 0 0 1 0 0.899 1.000 1.000 306 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(3), IL4R(5), IRS1(2), JAK1(1), JAK3(4), RPS6KB1(1), STAT6(3) 4259839 19 15 18 5 11 1 5 0 2 0 0.349 1.000 1.000 307 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 IL5(1), JUNB(2), MAP2K3(2), NFATC1(4), NFATC2(4), PRKAR2A(1) 3256961 14 13 14 9 10 2 1 0 1 0 0.933 1.000 1.000 308 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 29 AKR1C4(2), AKR1D1(2), ARSE(1), CYP11B1(1), CYP11B2(3), HSD11B2(1), HSD3B1(2), HSD3B2(1), STS(2), SULT1E1(1), UGT1A1(2), UGT1A4(1), UGT1A5(1), UGT1A6(1), UGT2B15(5), UGT2B4(1) 7811721 27 24 27 8 15 2 3 4 3 0 0.391 1.000 1.000 309 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(3), GART(1), MTHFD1(1), MTHFD1L(2), MTHFD2(2), MTHFR(4), MTR(2), SHMT1(2), SHMT2(1) 5231737 18 17 18 8 9 1 3 2 3 0 0.864 1.000 1.000 310 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(1), CRY1(1), CRY2(1), CSNK1D(2), NPAS2(4), NR1D1(2), PER1(3), PER2(1), PER3(7) 4901223 22 20 22 7 14 3 2 1 2 0 0.677 1.000 1.000 311 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(5), APC(7), BTRC(1), CTNNB1(5), DLL1(1), FZD1(1), NOTCH1(14), PSEN1(4), WNT1(1) 6114748 39 26 37 9 19 2 10 5 3 0 0.402 1.000 1.000 312 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(1), F2R(1), F5(7), F7(2), FGA(6), FGG(1), PROS1(2), SERPINC1(1), TFPI(1) 4770264 22 15 21 5 14 2 5 0 1 0 0.416 1.000 1.000 313 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(4), ADRB2(2), GNAS(6), PLCE1(9), PRKAR2A(1) 4142653 22 20 22 7 14 0 5 1 2 0 0.601 1.000 1.000 314 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(1), DHCR24(1), FDFT1(2), FDPS(4), GGCX(3), HMGCR(1), HSD17B7(2), IDI1(1), IDI2(2), LSS(2), MVD(1), MVK(1), NQO1(1), NSDHL(2), PMVK(1), SQLE(2), TM7SF2(1), VKORC1(1) 5617871 29 22 29 9 17 1 3 4 4 0 0.424 1.000 1.000 315 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(1), HMOX1(2), IL1A(2), IL6(1), JAK1(1), STAT1(2), STAT3(2), STAT5A(2) 3470674 13 10 13 7 9 0 3 0 1 0 0.816 1.000 1.000 316 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMB1(1), PSMB2(1), PSMB3(1), PSMB6(1), PSMC2(2), PSMC3(1), PSMD2(2), PSMD6(1) 4691828 11 9 11 4 4 2 2 1 2 0 0.778 1.000 1.000 317 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(1), CHPT1(1), HEMK1(1), LCMT1(4), LCMT2(1), METTL2B(1), PCYT1A(2), PCYT1B(1), PRMT2(1), PRMT5(1), PRMT6(1), PRMT7(3) 4042012 18 16 18 6 12 1 3 0 2 0 0.612 1.000 1.000 318 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 CALM1(2), CALM3(1), CDKN1A(1), GNAQ(2), NFATC1(4), NFATC2(4), NFATC3(5), NFATC4(3), PLCG1(3), PPP3CA(1), PPP3CC(1), PRKCA(3), SP1(3), SP3(2), SYT1(2) 5774104 37 24 37 9 27 2 6 1 1 0 0.345 1.000 1.000 319 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(1), GUSB(4), UGP2(2), UGT1A1(2), UGT1A4(1), UGT1A5(1), UGT1A6(1), UGT2A1(2), UGT2A3(3), UGT2B10(3), UGT2B11(3), UGT2B15(5), UGT2B17(3), UGT2B4(1), UGT2B7(1), XYLB(1) 7956976 34 27 34 8 23 0 2 8 1 0 0.276 1.000 1.000 320 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(3), ACADS(3), ACAT1(2), ACAT2(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH5A1(1), ALDH9A1(2), EHHADH(1), GAD1(4), L2HGDH(1), PDHA1(1), PDHA2(4), PDHB(2), SDHB(1), SDS(1) 7484637 38 26 37 9 20 2 6 6 4 0 0.239 1.000 1.000 321 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 ANPEP(1), G6PD(1), GCLM(1), GSTA2(2), GSTA3(2), GSTA4(1), GSTM2(1), GSTM4(1), GSTT1(2), GSTT2(1), GSTZ1(1), MGST3(1), PGD(2) 5440784 17 16 17 9 9 1 5 0 2 0 0.818 1.000 1.000 322 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(1), CARS2(1), CDO1(2), GOT2(1), LDHAL6A(1), LDHAL6B(1), LDHC(3), SDS(1), SULT1B1(3), SULT1C4(1), SULT4A1(1) 3608770 16 14 16 5 12 0 3 1 0 0 0.541 1.000 1.000 323 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 FUCA2(3), GLB1(4), HEXB(2), LCT(3), MANBA(2), NEU1(2) 4509828 16 14 16 9 6 2 5 1 2 0 0.924 1.000 1.000 324 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 ELK1(2), EPOR(1), FOS(2), HRAS(1), JAK2(6), JUN(2), MAP2K1(2), MAPK3(1), MAPK8(1), PLCG1(3), SOS1(5), STAT5A(2), STAT5B(1) 6360634 29 23 29 9 13 2 9 1 3 1 0.539 1.000 1.000 325 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), EHHADH(1), SDS(1) 3542611 15 13 15 5 9 0 2 3 1 0 0.561 1.000 1.000 326 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR1(3), CCR2(1), CCR3(1), CCR4(2), CCR7(1), CD4(1), CXCR3(1), CXCR4(3), IFNG(1), IFNGR1(6), IFNGR2(3), IL12A(2), IL12B(2), IL12RB1(1), IL12RB2(2), IL18R1(2), IL4R(5), IL5(1), TGFB2(1), TGFB3(2) 5927664 41 34 40 13 20 5 6 1 9 0 0.417 1.000 1.000 327 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 B4GALT3(1), B4GALT5(1), DPAGT1(1), FUT8(3), MAN1A1(1), MAN1B1(3), MGAT2(1), MGAT3(3), MGAT5(2), RPN1(2), ST6GAL1(2) 5578702 20 16 20 9 11 1 5 0 3 0 0.799 1.000 1.000 328 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 49 ACOX1(1), CD36(2), CPT1B(3), CREBBP(15), DUSP1(1), EHHADH(1), EP300(23), FABP1(1), HSD17B4(10), JUN(2), LPL(2), MAPK1(9), MAPK3(1), ME1(1), MYC(1), NCOA1(4), NCOR1(5), NCOR2(6), NFKBIA(2), NR1H3(3), NRIP1(4), PIK3CA(58), PIK3R1(10), PPARA(1), PRKAR2A(1), PRKCA(3), PTGS2(2), RB1(9), RELA(7), RXRA(1), SP1(3), SRA1(1), STAT5A(2), STAT5B(1) 18279619 196 99 146 31 118 9 29 13 22 5 0.000222 1.000 1.000 329 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(1), ABCC2(3), ABCG2(2), BCHE(4), CES1(3), CES2(1), CYP3A5(2), UGT1A1(2), UGT1A4(1), UGT1A5(1), UGT1A6(1) 6622474 21 18 21 7 10 0 5 5 1 0 0.545 1.000 1.000 330 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(5), ACACB(6), ACAT1(2), ACAT2(1), ACOT12(1), ACSS1(3), ACSS2(2), AKR1B1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), DLAT(2), GLO1(1), GRHPR(1), LDHAL6A(1), LDHAL6B(1), LDHC(3), LDHD(1), MDH1(1), MDH2(1), ME1(1), ME2(3), PC(1), PCK2(1), PDHA1(1), PDHA2(4), PDHB(2), PKLR(3) 13542411 58 41 57 10 36 4 6 9 3 0 0.0273 1.000 1.000 331 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(1), ACTN2(2), CTNNA1(2), CTNNA2(4), CTNNB1(5), PTK2(2), PXN(2), VCL(3) 5666744 21 17 20 8 7 1 7 3 3 0 0.770 1.000 1.000 332 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(1), ALDOA(3), ALDOB(1), ALDOC(1), FPGT(2), GCK(2), GMDS(1), GMPPA(1), HK1(2), HK2(4), HK3(1), KHK(2), PFKFB1(1), PMM2(1) 7129965 23 19 23 8 14 2 4 1 2 0 0.450 1.000 1.000 333 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1R(1), C1S(1), C2(1), C3(6), C5(3), C6(5), C7(3), C8B(2), C9(1), MASP1(1) 5917088 24 17 24 9 13 3 5 1 2 0 0.784 1.000 1.000 334 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(2), ARFGAP3(1), ARFGEF2(6), CLTA(1), CLTB(1), COPA(2), GBF1(5), GPLD1(2), KDELR1(2), KDELR3(2) 4728569 24 18 24 8 17 0 3 2 2 0 0.632 1.000 1.000 335 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(1), ADH1B(2), ADH4(1), ADH6(1), ADH7(1), ADHFE1(1), DHRS1(1), DHRS3(2), DHRSX(4), ESCO1(1), ESCO2(1), NAT6(1), PNPLA3(1), SH3GLB1(2) 7189961 20 18 20 6 10 0 5 2 3 0 0.624 1.000 1.000 336 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 CA14(3), CA2(1), CA4(1), CA6(2), CA7(1), CA8(1), CPS1(1), GLS2(2), GLUD1(2), GLUL(1), HAL(1) 5488607 16 14 16 7 9 0 2 3 2 0 0.834 1.000 1.000 337 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(3), ALDOB(1), ALDOC(1), GOT2(1), GPT2(2), MDH1(1), MDH2(1), ME1(1), ME2(3), PGK1(1), PKLR(3), TKT(1) 5215091 19 16 19 8 8 2 6 1 2 0 0.730 1.000 1.000 338 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), AOC2(1), AOC3(3), ASPA(1), DDC(2), HAL(1), HDC(2), MAOA(1), MAOB(3), PRPS2(2) 7103244 29 25 29 9 19 0 5 4 1 0 0.436 1.000 1.000 339 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ACADM(4), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), AOC2(1), AOC3(3), DPYD(3), DPYS(1), EHHADH(1), GAD1(4), HIBCH(1), SMS(1), SRM(1) 7731074 29 19 29 9 15 1 3 5 5 0 0.491 1.000 1.000 340 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA2(1), ACAD8(1), ADH1B(2), ADH4(1), ADH6(1), ADH7(1), ADHFE1(1), AKR1C4(2), AKR1D1(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), BAAT(4), CEL(3), CYP27A1(3), CYP7A1(2), HSD3B7(1), LIPA(1), RDH13(1), SLC27A5(7), SOAT2(2) 9246158 45 33 45 12 20 2 15 3 5 0 0.243 1.000 1.000 341 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(2), CPEB1(1), EGFR(7), ERBB2(11), ERBB4(4), ETS2(1), ETV6(2), FMN2(9), KRAS(11), MAP2K1(2), MAPK1(9), MAPK3(1), NOTCH1(14), NOTCH2(7), NOTCH3(7), NOTCH4(6), PIWIL1(3), PIWIL2(2), PIWIL3(5), PIWIL4(3), SOS1(5), SOS2(5), SPIRE1(1), SPIRE2(3) 14565421 121 74 105 23 61 4 37 7 12 0 0.0238 1.000 1.000 342 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(1), CSF1R(2), EGF(1), EGFR(7), MET(2), PDGFRA(2), PRKCA(3), SH3GLB1(2), SH3KBP1(2) 5676647 22 17 22 7 14 0 6 0 2 0 0.572 1.000 1.000 343 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1B(2), ADH4(1), ADH6(1), ADH7(1), ADHFE1(1), ALDH1A3(2), ALDH3A1(1), AOC2(1), AOC3(3), AOX1(3), DBH(1), DCT(2), DDC(2), FAH(3), GOT2(1), GSTZ1(1), HGD(2), HPD(2), MAOA(1), MAOB(3), TAT(3), TH(2), TPO(6), TYR(2) 9207084 47 32 47 11 28 1 11 3 4 0 0.118 1.000 1.000 344 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 FUCA2(3), GLB1(4), HEXB(2), LCT(3), MAN2B1(4), MAN2B2(2), MANBA(2), NEU1(2) 5616177 22 17 22 9 10 2 5 3 2 0 0.725 1.000 1.000 345 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(1), EPHA4(3), EPHB1(2), FYN(3), ITGA1(3), ITGB1(2), L1CAM(5), RAP1B(1) 4593801 20 17 20 9 9 0 10 0 1 0 0.858 1.000 1.000 346 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), AMDHD1(2), AOC2(1), AOC3(3), ASPA(1), CARM1(1), DDC(2), FTCD(3), HAL(1), HARS2(1), HDC(2), HEMK1(1), LCMT1(4), LCMT2(1), MAOA(1), MAOB(3), METTL2B(1), PRMT2(1), PRMT5(1), PRMT6(1), PRMT7(3), PRPS2(2), UROC1(7) 11531049 52 42 52 12 27 1 14 4 6 0 0.108 1.000 1.000 347 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), CYP2C19(1), CYP2C9(3), DHRS1(1), DHRS3(2), DHRSX(4), EHHADH(1), ESCO1(1), ESCO2(1), NAT6(1), PNPLA3(1), SH3GLB1(2) 8928809 27 21 27 7 15 0 5 5 2 0 0.408 1.000 1.000 348 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(1), EGFR(7), MAP2K1(2), MAP3K1(4), NCOR2(6), RXRA(1), THRA(1) 5119940 22 17 22 8 10 0 10 1 1 0 0.679 1.000 1.000 349 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 BHMT(1), CBS(1), DNMT1(3), DNMT3A(2), MARS(2), MARS2(2), MAT1A(1), MTR(2) 5133569 14 12 14 9 8 0 3 2 1 0 0.963 1.000 1.000 350 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BAD(2), BRAF(2), CREB1(2), CREB3(1), CREB5(5), DUSP9(1), EEF2K(2), MAP2K1(2), MAP3K8(1), MAPK1(9), MAPK3(1), MKNK1(1), MKNK2(2), NFKB1(2), RAP1A(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), SOS1(5), SOS2(5), TRAF3(3) 8651714 52 39 45 12 28 1 12 4 7 0 0.290 1.000 1.000 351 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 GALNS(2), GLB1(4), GNS(3), GUSB(4), HEXB(2), HGSNAT(1), HPSE2(2), HYAL1(1), HYAL2(1), IDS(8), LCT(3), NAGLU(1), SPAM1(1) 6026095 33 23 33 10 18 3 7 2 3 0 0.382 1.000 1.000 352 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(2), CALM3(1), CAMK1(2), CAMK2A(3), CAMK2B(1), CAMK2D(2), CAMK4(2), ESRRA(1), HDAC5(2), MEF2A(1), MEF2B(1), MEF2C(1), MEF2D(3), PPARA(1), PPP3CA(1), PPP3CC(1), SYT1(2) 6139147 27 18 27 9 15 3 3 4 2 0 0.608 1.000 1.000 353 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(3), MAP2(10), PRKAG1(1), PRKAR2A(1), PRKCE(1) 5273842 16 14 16 7 9 0 5 1 1 0 0.952 1.000 1.000 354 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(5), ACACB(6), FASN(4), MCAT(1), OLAH(1), OXSM(1) 4713290 18 18 18 8 13 0 2 2 1 0 0.759 1.000 1.000 355 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AMD1(5), BHMT(1), CBS(1), DNMT1(3), DNMT3A(2), MARS(2), MARS2(2), MAT1A(1), MTR(2), SRM(1), TAT(3) 6096503 23 18 23 9 12 0 7 2 2 0 0.735 1.000 1.000 356 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(2), AGTR1(1), ATF2(2), CALM1(2), CALM3(1), EGFR(7), ELK1(2), GNAQ(2), HRAS(1), JUN(2), MAP2K1(2), MAP3K1(4), MAPK1(9), MAPK3(1), MAPK8(1), MEF2A(1), MEF2B(1), MEF2C(1), MEF2D(3), PAK1(1), PRKCA(3), PTK2(2), PTK2B(3), RAC1(1), SOS1(5), SYT1(2) 9963554 62 39 56 14 35 6 12 4 5 0 0.201 1.000 1.000 357 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL22RA1(1), JAK1(1), JAK2(6), JAK3(4), SOCS3(6), STAT1(2), STAT3(2), STAT5A(2), STAT5B(1), TYK2(9) 5389356 34 27 34 10 18 2 5 2 5 2 0.378 1.000 1.000 358 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(1), AGT(2), AGTR1(1), ANPEP(1), CPA3(1), CTSA(1), CTSG(1), ENPEP(5), LNPEP(1), MAS1(2), MME(2), NLN(4), REN(1), THOP1(4) 6158481 27 21 27 9 15 2 7 1 2 0 0.532 1.000 1.000 359 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(5), ACAT1(2), ACAT2(1), AKR1B1(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), DLAT(2), GLO1(1), GRHPR(1), LDHC(3), LDHD(1), MDH1(1), MDH2(1), ME1(1), ME2(3), PC(1), PDHA1(1), PDHA2(4), PDHB(2), PKLR(3) 10697525 47 34 46 10 28 4 5 7 3 0 0.144 1.000 1.000 360 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(1), GUSB(4), UCHL1(1), UGT1A1(2), UGT1A4(1), UGT1A5(1), UGT1A6(1), UGT2B15(5), UGT2B4(1) 5129046 17 13 17 6 12 0 0 4 1 0 0.615 1.000 1.000 361 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(1), EGF(1), EGFR(7), HRAS(1), MAP2K1(2), MAPK1(9), MAPK3(1), PTPRB(5), RASA1(4), SOS1(5), SPRY1(2), SPRY3(2), SPRY4(2) 7282160 42 33 36 10 22 2 12 2 4 0 0.340 1.000 1.000 362 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(2), ACP5(1), ACPT(5), ALPI(3), ALPL(1), ALPP(2), ALPPL2(1), CYP19A1(1), CYP1A1(1), CYP1A2(1), CYP2A13(1), CYP2A6(2), CYP2A7(5), CYP2C18(3), CYP2C19(1), CYP2C9(3), CYP2E1(1), CYP2F1(1), CYP2J2(2), CYP3A5(2), CYP3A7(1), PON1(1) 8544552 41 30 41 12 29 1 10 1 0 0 0.148 1.000 1.000 363 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(1), ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), ATP7A(3), ATP7B(5), COX10(1), COX4I1(1), COX5A(2), COX6A1(1), COX7A2(1), COX8A(1), NDUFA1(1), NDUFA11(1), NDUFA5(1), NDUFA8(1), NDUFB7(2), NDUFS1(1), NDUFS2(1), NDUFV1(3), SDHA(4), SDHB(1), SHMT1(2), UQCRB(2), UQCRC1(1), UQCRFS1(1) 11285860 52 36 52 12 20 2 14 2 14 0 0.166 1.000 1.000 364 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(2), ACAT2(1), DHRS1(1), DHRS3(2), DHRSX(4), EHHADH(1), ESCO1(1), ESCO2(1), GCDH(2), NAT6(1), PNPLA3(1), SH3GLB1(2) 7504907 19 16 19 6 8 1 5 3 2 0 0.657 1.000 1.000 365 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(3), ALDOB(1), ALDOC(1), G6PD(1), GPI(3), H6PD(2), PGD(2), PGM3(1), PRPS2(2), TKT(1) 5745448 17 15 17 7 7 2 6 1 1 0 0.663 1.000 1.000 366 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(11), ATR(6), BRCA1(5), CDC25A(2), CDC25B(4), CDC25C(2), CDKN1A(1), CHEK1(1), CHEK2(1), EP300(23), MDM2(1), MYT1(4), PRKDC(11), RPS6KA1(1), TP53(12), YWHAQ(2) 12552388 87 52 80 15 57 2 10 3 12 3 0.0949 1.000 1.000 367 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(5), CARM1(1), CCND1(1), CREBBP(15), EP300(23), ERCC3(1), ESR1(1), GRIP1(9), GTF2A1(1), GTF2E1(1), HDAC3(3), HDAC4(3), HDAC5(2), HDAC6(4), MEF2C(1), NCOR2(6), NR0B1(2), NRIP1(4), POLR2A(5), SRA1(1), TBP(1) 13830812 90 53 85 21 43 3 21 5 13 5 0.155 1.000 1.000 368 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(1), G6PC(3), GAA(4), GALK1(2), GALK2(1), GALT(2), GANAB(4), GCK(2), GLA(1), GLB1(4), HK1(2), HK2(4), HK3(1), LCT(3), MGAM(12), PGM3(1) 9518121 47 35 46 14 23 5 7 3 9 0 0.299 1.000 1.000 369 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA2(1), ACADM(4), ACADS(3), ACADVL(2), ACAT1(2), ACAT2(1), ACOX1(1), ACOX3(2), ACSL1(1), ACSL3(2), ACSL4(5), ACSL5(2), ACSL6(1), ADH1B(2), ADH4(1), ADH6(1), ADH7(1), ADHFE1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), CPT1A(4), CPT1B(3), CPT1C(1), CPT2(1), CYP4A22(2), EHHADH(1), GCDH(2), HADH(1), HSD17B10(1), HSD17B4(10) 14239233 68 38 68 16 32 4 13 8 11 0 0.113 1.000 1.000 370 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 FUCA2(3), GALNS(2), GLB1(4), GNS(3), GUSB(4), HEXB(2), HGSNAT(1), HPSE2(2), HYAL1(1), HYAL2(1), IDS(8), LCT(3), MAN2B1(4), MAN2B2(2), MANBA(2), NAGLU(1), NEU1(2), SPAM1(1) 9824329 46 27 46 13 26 3 9 4 4 0 0.259 1.000 1.000 371 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(1), AKT1(3), AKT2(1), AKT3(3), ARHGAP4(6), ARHGEF11(8), BTK(4), CDC42(1), GDI1(2), INPPL1(4), ITPR1(8), ITPR2(5), ITPR3(2), LIMK1(4), MYLK(2), PAK1(1), PAK2(1), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PDK1(3), PIK3CA(58), PIK3CD(1), PIK3CG(1), PIK3R1(10), PITX2(2), PPP1R13B(2), PTEN(17), RACGAP1(1), ROCK1(3), ROCK2(4), RPS4X(2), SAG(1), WASF1(3), WASL(4) 20567895 176 96 134 30 107 5 21 13 30 0 0.000554 1.000 1.000 372 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 DLAT(2), FH(1), IDH3A(2), IDH3B(1), IDH3G(1), MDH1(1), MDH2(1), OGDH(4), PC(1), PDHA1(1), PDHA2(4), PDHB(2), PDHX(2), PDK1(3), PDK2(1), PDK3(1), PDK4(1), PDP2(1), SDHA(4), SDHB(1), SDHD(1), SUCLA2(1), SUCLG1(1), SUCLG2(1) 8378522 39 33 38 10 18 1 9 2 9 0 0.321 1.000 1.000 373 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(5), POLA2(1), POLB(1), POLD1(3), POLD2(1), POLD3(1), POLE(7), POLG(3), POLG2(2), POLI(1), POLK(4), POLL(1), POLM(4), POLQ(13), PRIM1(1), REV1(2), REV3L(3), RFC5(2) 12101557 55 32 55 10 29 1 9 4 12 0 0.186 1.000 1.000 374 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(1), AMY2A(3), AMY2B(3), ENPP1(2), ENPP3(5), G6PC(3), GAA(4), GANAB(4), GCK(2), GPI(3), GUSB(4), GYS1(2), GYS2(2), HK1(2), HK2(4), HK3(1), MGAM(12), PGM3(1), PYGB(3), PYGM(1), RNPC3(3), SI(12), UCHL1(1), UGT1A1(2), UGT1A4(1), UGT1A5(1), UGT1A6(1), UGT2B15(5), UGT2B4(1), UXS1(2) 16838795 91 62 91 22 42 5 20 12 12 0 0.176 1.000 1.000 375 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(2), CREBBP(15), DUSP1(1), EP300(23), IKBKB(2), IL8(2), MAP2K3(2), MAPK11(2), NFKB1(2), NFKBIA(2), NR3C1(4), RELA(7), TGFBR1(1), TGFBR2(5), TLR2(2) 8618050 72 49 67 17 34 5 11 2 16 4 0.302 1.000 1.000 376 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 39 ALK(3), AR(8), ESR1(1), ESRRA(1), HNF4A(3), NPM1(1), NR0B1(2), NR1D1(2), NR1D2(2), NR1H2(4), NR1H3(3), NR1I2(2), NR2C2(1), NR2E1(4), NR2F2(3), NR3C1(4), NR4A1(1), NR5A2(2), PGR(2), PPARA(1), PPARD(2), PPARG(1), RARB(5), RARG(5), ROR1(1), RORA(1), RORC(1), RXRA(1), THRA(1), VDR(1) 11816018 69 44 68 18 42 0 16 6 5 0 0.169 1.000 1.000 377 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(1), ALAS2(2), AOC2(1), AOC3(3), BHMT(1), CBS(1), CHDH(1), CHKA(2), CHKB(3), DAO(1), DMGDH(1), GARS(1), GCAT(3), GLDC(3), GNMT(1), HSD3B7(1), MAOA(1), MAOB(3), PEMT(1), PSPH(1), RDH13(1), SARDH(2), SARS(1), SARS2(3), SDS(1), SHMT1(2), SHMT2(1), TARS(2), TARS2(3) 12578325 48 30 48 12 30 1 11 3 3 0 0.150 1.000 1.000 378 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 53 AKR1C4(2), AKR1D1(2), ARSE(1), CARM1(1), CYP11B1(1), CYP11B2(3), CYP19A1(1), HEMK1(1), HSD11B2(1), HSD17B12(1), HSD17B7(2), HSD3B1(2), HSD3B2(1), LCMT1(4), LCMT2(1), METTL2B(1), PRMT2(1), PRMT5(1), PRMT6(1), PRMT7(3), STS(2), SULT1E1(1), SULT2B1(3), UGT1A1(2), UGT1A4(1), UGT1A5(1), UGT1A6(1), UGT2A1(2), UGT2A3(3), UGT2B10(3), UGT2B11(3), UGT2B15(5), UGT2B17(3), UGT2B4(1), UGT2B7(1) 14461835 63 50 63 16 36 3 9 10 5 0 0.184 1.000 1.000 379 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(7), ASAH1(2), CASP3(1), CERK(3), CREB1(2), CREB3(1), CREB5(5), DAG1(3), EPHB2(3), FOS(2), GNAQ(2), ITPKA(1), ITPKB(1), JUN(2), MAP2K7(1), MAPK1(9), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(2), MAPK9(4) 8182750 54 41 47 13 36 0 13 2 3 0 0.269 1.000 1.000 380 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(1), ALAS2(2), AOC2(1), AOC3(3), BHMT(1), CBS(1), CHDH(1), CHKA(2), CHKB(3), CPT1B(3), DAO(1), DMGDH(1), GARS(1), GCAT(3), GLDC(3), MAOA(1), MAOB(3), PEMT(1), PLCB2(2), PLCG1(3), PLCG2(4), PSPH(1), SARDH(2), SARS(1), SHMT1(2), SHMT2(1), TARS(2) 12355700 50 31 50 13 28 2 12 5 3 0 0.193 1.000 1.000 381 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1B(2), ADH4(1), ADH6(1), ADH7(1), ADHFE1(1), AGPAT2(1), AGPAT4(1), AKR1A1(1), AKR1B1(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), CEL(3), DGAT1(2), DGKA(3), DGKB(1), DGKE(1), DGKG(3), DGKH(2), DGKQ(1), DGKZ(5), GK(2), GLA(1), GLB1(4), LCT(3), LIPC(2), LIPF(1), LIPG(2), LPL(2), PNLIP(3), PNLIPRP1(3), PNLIPRP2(2), PPAP2B(4) 14131257 73 49 73 20 34 3 20 4 12 0 0.197 1.000 1.000 382 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1B(2), ADH4(1), ADH6(1), ADH7(1), ADHFE1(1), AKR1A1(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), ALDOA(3), ALDOB(1), ALDOC(1), DLAT(2), ENO1(3), ENO3(4), G6PC(3), GAPDH(1), GCK(2), GPI(3), HK1(2), HK2(4), HK3(1), LDHC(3), PDHA1(1), PDHA2(4), PDHB(2), PGAM1(1), PGK1(1), PGM3(1), PKLR(3) 14232734 66 42 65 17 37 3 11 6 9 0 0.135 1.000 1.000 383 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1B(2), ADH4(1), ADH6(1), ADH7(1), ADHFE1(1), AKR1A1(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), ALDOA(3), ALDOB(1), ALDOC(1), DLAT(2), ENO1(3), ENO3(4), G6PC(3), GAPDH(1), GCK(2), GPI(3), HK1(2), HK2(4), HK3(1), LDHC(3), PDHA1(1), PDHA2(4), PDHB(2), PGAM1(1), PGK1(1), PGM3(1), PKLR(3) 14232734 66 42 65 17 37 3 11 6 9 0 0.135 1.000 1.000 384 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(4), CALM1(2), CALM3(1), CREB1(2), ELK1(2), FOS(2), GNAI1(1), GNAQ(2), GNAS(6), GNB1(1), GNGT1(1), HRAS(1), JUN(2), MAP2K1(2), MAPK3(1), NFATC1(4), NFATC2(4), NFATC3(5), NFATC4(3), PLCG1(3), PPP3CA(1), PPP3CC(1), PRKAR2A(1), PRKCA(3), RPS6KA3(2), SYT1(2) 9832491 59 38 59 15 38 2 13 3 3 0 0.267 1.000 1.000 385 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(2), ACTG1(5), ACTN1(1), ACTN2(2), ACTN4(2), AKT1(3), AKT2(1), AKT3(3), ARHGAP5(4), BAD(2), BIRC2(2), BIRC3(1), BRAF(2), CAV2(1), CCND1(1), CDC42(1), COL11A1(11), COL11A2(5), COL1A1(2), COL1A2(3), COL2A1(7), COL3A1(5), COL4A1(4), COL4A2(4), COL4A4(2), COL4A6(4), COL5A1(6), COL5A2(6), COL5A3(3), COL6A1(3), COL6A2(4), COL6A3(10), COL6A6(6), COMP(3), CRK(1), CTNNB1(5), DIAPH1(1), DOCK1(4), EGF(1), EGFR(7), ELK1(2), ERBB2(11), FARP2(3), FIGF(1), FLNA(10), FLNB(7), FLNC(11), FLT1(7), FN1(5), FYN(3), HGF(5), HRAS(1), IGF1R(3), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(3), ITGA2B(1), ITGA3(1), ITGA4(6), ITGA5(2), ITGA7(4), ITGA8(5), ITGA9(2), ITGAV(1), ITGB1(2), ITGB3(3), ITGB4(7), ITGB5(1), ITGB6(2), ITGB7(1), ITGB8(2), JUN(2), KDR(2), LAMA1(7), LAMA2(11), LAMA3(4), LAMA4(5), LAMA5(8), LAMB1(2), LAMB2(6), LAMB3(4), LAMB4(1), LAMC1(4), LAMC2(3), LAMC3(4), MAP2K1(2), MAPK1(9), MAPK3(1), MAPK8(1), MAPK9(4), MET(2), MYL5(1), MYL9(1), MYLK(2), MYLPF(1), PAK1(1), PAK2(1), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PARVB(2), PDGFC(1), PDGFRA(2), PDGFRB(2), PDPK1(2), PIK3CA(58), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(10), PIK3R3(4), PIP5K1C(3), PPP1CB(2), PPP1CC(1), PPP1R12A(7), PRKCA(3), PRKCG(1), PTEN(17), PTK2(2), PXN(2), RAC1(1), RAC2(1), RAC3(1), RAP1A(1), RAP1B(1), RAPGEF1(4), RELN(7), RHOA(2), ROCK1(3), ROCK2(4), SHC2(3), SHC3(1), SOS1(5), SOS2(5), SPP1(3), THBS1(2), THBS2(2), THBS3(2), THBS4(1), TLN1(3), TLN2(1), TNC(9), TNN(1), TNXB(7), VASP(1), VAV1(2), VAV2(3), VAV3(3), VCL(3), VEGFA(1), VEGFC(4), VWF(6), ZYX(1) 108179318 574 150 519 180 317 23 124 38 72 0 0.665 1.000 1.000 386 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 246 ACVR1B(2), ACVR1C(1), AKT1(3), AKT2(1), AKT3(3), ARRB1(2), ATF2(2), ATF4(2), BRAF(2), CACNA1A(4), CACNA1B(9), CACNA1C(9), CACNA1D(4), CACNA1E(6), CACNA1F(6), CACNA1G(4), CACNA1H(8), CACNA1I(5), CACNA1S(3), CACNA2D1(3), CACNA2D2(3), CACNA2D3(3), CACNA2D4(3), CACNB1(2), CACNB2(2), CACNB3(2), CACNB4(7), CACNG3(1), CACNG5(1), CACNG6(1), CACNG7(3), CACNG8(1), CASP3(1), CD14(3), CDC25B(4), CDC42(1), CHUK(2), CRK(1), DAXX(2), DDIT3(1), DUSP1(1), DUSP10(1), DUSP16(2), DUSP5(2), DUSP7(2), DUSP8(1), DUSP9(1), EGF(1), EGFR(7), ELK1(2), ELK4(3), FAS(5), FASLG(1), FGF1(1), FGF11(1), FGF14(2), FGF17(1), FGF18(1), FGF2(1), FGF21(1), FGF3(1), FGF4(1), FGF8(1), FGF9(1), FGFR1(1), FGFR2(2), FGFR4(2), FLNA(10), FLNB(7), FLNC(11), FOS(2), GADD45B(1), GNA12(2), HRAS(1), IKBKB(2), IL1A(2), IL1R1(2), IL1R2(2), JUN(2), KRAS(11), MAP2K1(2), MAP2K3(2), MAP2K7(1), MAP3K1(4), MAP3K10(2), MAP3K12(3), MAP3K13(1), MAP3K2(1), MAP3K3(1), MAP3K4(6), MAP3K5(11), MAP3K6(4), MAP3K8(1), MAP4K1(3), MAP4K2(2), MAP4K3(1), MAP4K4(3), MAPK1(9), MAPK11(2), MAPK13(1), MAPK3(1), MAPK7(2), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(2), MAPK9(4), MAPKAPK2(2), MAPKAPK3(1), MAPKAPK5(1), MAPT(2), MAX(2), MEF2C(1), MKNK1(1), MKNK2(2), MRAS(1), MYC(1), NF1(10), NFATC2(4), NFATC4(3), NFKB1(2), NFKB2(1), NR4A1(1), NRAS(1), NTRK2(1), PAK1(1), PAK2(1), PDGFRA(2), PDGFRB(2), PLA2G12A(1), PLA2G12B(3), PLA2G2D(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PPM1B(1), PPP3CA(1), PPP3CC(1), PPP5C(4), PRKACA(2), PRKCA(3), PRKCG(1), PTPN5(1), PTPRR(1), RAC1(1), RAC2(1), RAC3(1), RAP1A(1), RAP1B(1), RAPGEF2(4), RASA1(4), RASA2(6), RASGRF1(1), RASGRF2(1), RASGRP1(1), RASGRP2(5), RASGRP4(5), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA4(1), RPS6KA5(2), RPS6KA6(6), SOS1(5), SOS2(5), STK3(2), STK4(2), STMN1(1), TAOK1(2), TAOK2(6), TAOK3(3), TGFB2(1), TGFB3(2), TGFBR1(1), TGFBR2(5), TNFRSF1A(4), TP53(12), TRAF2(1), TRAF6(1), ZAK(5) 85378227 469 141 452 158 256 19 123 26 43 2 0.457 1.000 1.000 387 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 199 ABI2(1), ACTN1(1), ACTN2(2), ACTN4(2), APC(7), ARAF(1), ARHGEF1(1), ARHGEF12(6), ARHGEF4(5), ARHGEF6(1), ARHGEF7(4), ARPC1A(2), ARPC2(3), BRAF(2), CD14(3), CDC42(1), CHRM1(1), CHRM2(3), CHRM3(3), CHRM4(1), CHRM5(1), CRK(1), CYFIP1(5), DIAPH1(1), DIAPH2(4), DIAPH3(3), DOCK1(4), EGF(1), EGFR(7), EZR(6), F2R(1), FGD1(2), FGD3(4), FGF1(1), FGF11(1), FGF14(2), FGF17(1), FGF18(1), FGF2(1), FGF21(1), FGF3(1), FGF4(1), FGF8(1), FGF9(1), FGFR1(1), FGFR2(2), FGFR4(2), FN1(5), GNA12(2), GNA13(3), GSN(2), HRAS(1), IQGAP1(10), IQGAP2(4), IQGAP3(4), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(3), ITGA2B(1), ITGA3(1), ITGA4(6), ITGA5(2), ITGA7(4), ITGA8(5), ITGA9(2), ITGAD(1), ITGAE(3), ITGAL(4), ITGAM(4), ITGAV(1), ITGAX(3), ITGB1(2), ITGB3(3), ITGB4(7), ITGB5(1), ITGB6(2), ITGB7(1), ITGB8(2), KRAS(11), LIMK1(4), LIMK2(2), MAP2K1(2), MAPK1(9), MAPK3(1), MRAS(1), MSN(2), MYH10(9), MYH14(3), MYH9(16), MYL5(1), MYL9(1), MYLK(2), MYLPF(1), NCKAP1(3), NCKAP1L(2), NRAS(1), PAK1(1), PAK2(1), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PDGFRA(2), PDGFRB(2), PIK3CA(58), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(10), PIK3R3(4), PIP4K2A(1), PIP5K1A(1), PIP5K1B(1), PIP5K1C(3), PPP1CB(2), PPP1CC(1), PPP1R12A(7), PPP1R12B(3), PTK2(2), PXN(2), RAC1(1), RAC2(1), RAC3(1), RDX(2), RHOA(2), ROCK1(3), ROCK2(4), SCIN(1), SLC9A1(4), SOS1(5), SOS2(5), SSH1(1), SSH2(4), SSH3(2), TIAM1(4), TIAM2(4), TMSB4X(1), VAV1(2), VAV2(3), VAV3(3), VCL(3), WASF1(3), WASF2(2), WASL(4) 81657395 453 141 401 154 261 13 100 23 55 1 0.690 1.000 1.000 388 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(4), ADCY2(3), ADCY3(1), ADCY4(4), ADCY7(2), ADCY8(4), ADCY9(8), ADRA1A(3), ADRA1B(2), ADRA1D(1), ADRB2(2), AGTR1(1), ATP2A1(3), ATP2A2(3), ATP2A3(3), ATP2B1(3), ATP2B2(5), ATP2B3(3), ATP2B4(4), AVPR1A(1), AVPR1B(2), BST1(4), CACNA1A(4), CACNA1B(9), CACNA1C(9), CACNA1D(4), CACNA1E(6), CACNA1F(6), CACNA1G(4), CACNA1H(8), CACNA1I(5), CACNA1S(3), CALM1(2), CALM3(1), CALML6(1), CAMK2A(3), CAMK2B(1), CAMK2D(2), CAMK4(2), CCKAR(1), CCKBR(1), CHRM1(1), CHRM2(3), CHRM3(3), CHRM5(1), CHRNA7(1), CYSLTR1(2), CYSLTR2(1), EDNRA(1), EDNRB(2), EGFR(7), ERBB2(11), ERBB3(12), ERBB4(4), F2R(1), GNA11(2), GNA15(4), GNAL(2), GNAQ(2), GNAS(6), GRIN2A(4), GRIN2D(3), GRM1(3), GRM5(5), GRPR(4), HRH1(2), HRH2(1), HTR2B(2), HTR2C(2), HTR4(1), HTR5A(1), HTR6(3), HTR7(2), ITPKA(1), ITPKB(1), ITPR1(8), ITPR2(5), ITPR3(2), LHCGR(1), MYLK(2), NOS1(2), NOS3(6), NTSR1(1), OXTR(3), P2RX1(1), P2RX2(3), PDE1A(3), PDE1B(2), PDE1C(6), PDGFRA(2), PDGFRB(2), PHKA1(4), PHKA2(7), PHKB(3), PHKG2(1), PLCB1(10), PLCB2(2), PLCB3(2), PLCB4(1), PLCD1(2), PLCD3(3), PLCD4(2), PLCE1(9), PLCG1(3), PLCG2(4), PLCZ1(3), PPID(2), PPP3CA(1), PPP3CC(1), PRKACA(2), PRKCA(3), PRKCG(1), PTAFR(1), PTGER3(2), PTGFR(1), PTK2B(3), RYR1(10), RYR2(26), RYR3(11), SLC25A5(5), SLC8A1(1), SLC8A2(1), SPHK1(1), SPHK2(1), TACR1(1), TACR2(1), TBXA2R(1), TRPC1(5), VDAC1(1), VDAC2(1) 80199441 427 132 420 180 218 17 125 32 35 0 0.834 1.000 1.000 389 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(3), AKT2(1), AKT3(3), CBL(1), CBLB(5), CBLC(3), CCND1(1), CLCF1(1), CNTF(2), CREBBP(15), CRLF2(1), CSF2RB(2), CSF3R(3), EP300(23), EPOR(1), GH2(1), GHR(6), IFNA10(1), IFNA4(1), IFNA5(1), IFNA6(1), IFNA8(1), IFNAR1(3), IFNAR2(2), IFNG(1), IFNGR1(6), IFNGR2(3), IL11(1), IL11RA(2), IL12A(2), IL12B(2), IL12RB1(1), IL12RB2(2), IL13RA2(1), IL15(2), IL15RA(1), IL19(1), IL20(1), IL20RA(1), IL21(1), IL21R(1), IL22RA1(1), IL23A(1), IL23R(1), IL26(1), IL3RA(2), IL4R(5), IL5(1), IL5RA(2), IL6(1), IL6R(3), IL6ST(2), IL9R(3), IRF9(1), JAK1(1), JAK2(6), JAK3(4), LEP(1), LEPR(8), LIFR(2), MPL(1), MYC(1), OSMR(1), PIAS2(1), PIAS3(2), PIK3CA(58), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(10), PIK3R3(4), PIM1(1), PRL(3), PRLR(1), SOCS2(3), SOCS3(6), SOCS4(6), SOCS5(1), SOCS7(1), SOS1(5), SOS2(5), SPRED1(1), SPRED2(1), SPRY1(2), SPRY3(2), SPRY4(2), STAM(2), STAM2(2), STAT1(2), STAT2(3), STAT3(2), STAT4(4), STAT5A(2), STAT5B(1), STAT6(3), TPO(6), TYK2(9) 42273610 315 126 267 74 187 16 46 19 41 6 0.0149 1.000 1.000 390 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(8), ABLIM1(1), ABLIM2(1), ABLIM3(1), ARHGEF12(6), CDC42(1), CXCR4(3), DCC(9), DPYSL2(1), DPYSL5(5), EFNB2(1), EPHA1(1), EPHA2(10), EPHA3(5), EPHA4(3), EPHA5(6), EPHA7(3), EPHA8(2), EPHB1(2), EPHB2(3), EPHB3(4), EPHB4(1), EPHB6(4), FES(2), FYN(3), GNAI1(1), GNAI2(1), GNAI3(3), HRAS(1), ITGB1(2), KRAS(11), L1CAM(5), LIMK1(4), LIMK2(2), LRRC4C(2), MAPK1(9), MAPK3(1), MET(2), NCK1(2), NFAT5(5), NFATC1(4), NFATC2(4), NFATC3(5), NFATC4(3), NGEF(1), NRAS(1), NRP1(3), NTN1(1), NTN4(2), NTNG1(3), PAK1(1), PAK2(1), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PLXNA1(5), PLXNA2(4), PLXNA3(10), PLXNB1(5), PLXNB2(6), PLXNB3(4), PLXNC1(6), PPP3CA(1), PPP3CC(1), PTK2(2), RAC1(1), RAC2(1), RAC3(1), RASA1(4), RGS3(8), RHOA(2), RHOD(1), RND1(1), ROBO1(8), ROBO2(4), ROBO3(4), ROCK1(3), ROCK2(4), SEMA3A(3), SEMA3D(1), SEMA3E(2), SEMA3F(1), SEMA3G(1), SEMA4A(4), SEMA4B(7), SEMA4C(1), SEMA4F(3), SEMA4G(1), SEMA5A(2), SEMA5B(2), SEMA6A(3), SEMA6B(1), SEMA6C(3), SEMA6D(3), SLIT1(2), SLIT2(6), SLIT3(5), SRGAP1(6), SRGAP3(2), UNC5A(2), UNC5D(4) 57411405 325 122 313 110 167 16 92 16 34 0 0.473 1.000 1.000 391 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 129 ACACA(5), ACACB(6), AKT1(3), AKT2(1), AKT3(3), ARAF(1), BAD(2), BRAF(2), CALM1(2), CALM3(1), CALML6(1), CBL(1), CBLB(5), CBLC(3), CRK(1), ELK1(2), EXOC7(2), FASN(4), FLOT2(2), FOXO1(1), G6PC(3), G6PC2(1), GCK(2), GYS1(2), GYS2(2), HRAS(1), IKBKB(2), INPP5D(4), INSR(4), IRS1(2), IRS4(2), KRAS(11), LIPE(2), MAP2K1(2), MAPK1(9), MAPK3(1), MAPK8(1), MAPK9(4), MKNK1(1), MKNK2(2), NRAS(1), PCK2(1), PDE3A(5), PDPK1(2), PHKA1(4), PHKA2(7), PHKB(3), PHKG2(1), PIK3CA(58), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(10), PIK3R3(4), PKLR(3), PPARGC1A(1), PPP1CB(2), PPP1CC(1), PPP1R3A(6), PRKAA2(3), PRKACA(2), PRKAG1(1), PRKAG2(2), PRKAR2A(1), PRKCI(6), PRKCZ(1), PTPN1(1), PTPRF(7), PYGB(3), PYGM(1), RAPGEF1(4), RPS6KB1(1), RPS6KB2(1), SHC2(3), SHC3(1), SOCS2(3), SOCS3(6), SOCS4(6), SORBS1(5), SOS1(5), SOS2(5), SREBF1(3), TRIP10(3), TSC1(2), TSC2(6) 46645117 301 122 249 75 185 10 64 18 24 0 0.0169 1.000 1.000 392 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 130 ACTB(2), ACTG1(5), ACTN1(1), ACTN2(2), ACTN4(2), AKT1(3), AKT2(1), AKT3(3), AMOTL1(2), ASH1L(7), CASK(5), CDC42(1), CGN(5), CLDN10(1), CLDN16(2), CLDN18(2), CLDN2(2), CLDN22(1), CLDN8(1), CTNNA1(2), CTNNA2(4), CTNNA3(6), CTNNB1(5), CTTN(1), EPB41(4), EPB41L1(3), EPB41L2(1), EPB41L3(4), EXOC3(3), EXOC4(3), F11R(2), GNAI1(1), GNAI2(1), GNAI3(3), HCLS1(1), HRAS(1), INADL(4), KRAS(11), LLGL1(2), LLGL2(4), MAGI1(3), MAGI2(3), MAGI3(6), MLLT4(5), MPDZ(7), MPP5(6), MRAS(1), MYH1(7), MYH10(9), MYH11(3), MYH13(10), MYH14(3), MYH15(13), MYH2(9), MYH3(8), MYH4(5), MYH6(6), MYH7(8), MYH7B(6), MYH8(7), MYH9(16), MYL5(1), MYL9(1), MYLPF(1), NRAS(1), OCLN(1), PARD3(8), PARD6A(1), PARD6B(2), PPM1J(1), PPP2R1A(2), PPP2R2A(3), PPP2R2B(3), PPP2R2C(3), PPP2R3A(1), PPP2R4(1), PRKCA(3), PRKCD(1), PRKCE(1), PRKCG(1), PRKCH(1), PRKCI(6), PRKCQ(1), PRKCZ(1), PTEN(17), RAB13(1), RHOA(2), SPTAN1(11), SYMPK(4), TJP1(7), TJP2(8), TJP3(1), YES1(2), ZAK(5) 56936590 358 119 346 104 205 10 69 24 49 1 0.275 1.000 1.000 393 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(2), ACTG1(5), COL11A1(11), COL11A2(5), COL17A1(4), COL1A1(2), COL1A2(3), COL2A1(7), COL3A1(5), COL4A1(4), COL4A2(4), COL4A4(2), COL4A6(4), COL5A1(6), COL5A2(6), COL5A3(3), COL6A1(3), COL6A2(4), COL6A3(10), COL6A6(6), COMP(3), DSC1(1), DSC2(1), DSG1(2), DSG2(1), DSG3(8), DSG4(5), FN1(5), GJA1(2), GJA10(2), GJA5(1), GJA8(1), GJA9(2), GJB1(1), GJB5(1), GJB6(1), GJC1(1), GJC2(2), GJD2(2), INA(2), ITGB4(7), KRT1(6), KRT10(3), KRT13(1), KRT15(3), KRT16(1), KRT18(2), KRT2(2), KRT20(2), KRT24(2), KRT25(1), KRT27(1), KRT28(4), KRT31(2), KRT32(2), KRT33A(1), KRT34(1), KRT35(2), KRT36(1), KRT37(1), KRT38(2), KRT39(1), KRT4(1), KRT40(2), KRT5(2), KRT6A(2), KRT6B(5), KRT7(1), KRT71(2), KRT74(1), KRT75(1), KRT76(2), KRT79(2), KRT81(1), KRT82(1), KRT83(1), KRT84(2), KRT85(4), KRT86(3), KRT9(1), LAMA1(7), LAMA2(11), LAMA3(4), LAMA4(5), LAMA5(8), LAMB1(2), LAMB2(6), LAMB3(4), LAMB4(1), LAMC1(4), LAMC2(3), LAMC3(4), LMNB1(1), NES(3), PRPH(1), RELN(7), SPP1(3), THBS1(2), THBS2(2), THBS3(2), THBS4(1), TNC(9), TNN(1), TNXB(7), VIM(1), VWF(6) 72000831 327 118 326 118 179 13 71 27 37 0 0.957 1.000 1.000 394 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 237 ADCYAP1R1(3), ADORA1(1), ADORA3(3), ADRA1A(3), ADRA1B(2), ADRA2C(1), ADRB2(2), AGTR1(1), AVPR1A(1), AVPR1B(2), AVPR2(2), BRS3(3), C5AR1(2), CALCRL(1), CCKAR(1), CCKBR(1), CGA(1), CHRM1(1), CHRM2(3), CHRM3(3), CHRM4(1), CHRM5(1), CNR1(1), CNR2(1), CRHR1(2), CRHR2(2), CTSG(1), CYSLTR1(2), CYSLTR2(1), DRD3(2), EDNRA(1), EDNRB(2), F2R(1), F2RL2(1), F2RL3(2), FPR1(1), FSHR(2), GABBR1(5), GABBR2(2), GABRA1(1), GABRA2(2), GABRA4(1), GABRA5(1), GABRA6(1), GABRB1(2), GABRB2(1), GABRB3(4), GABRD(3), GABRE(1), GABRG1(3), GABRG2(3), GABRG3(4), GABRP(1), GABRQ(1), GABRR1(3), GALR2(1), GH2(1), GHR(6), GHSR(2), GIPR(3), GLP1R(1), GLRA1(1), GLRA2(2), GLRA3(3), GLRB(2), GPR156(2), GPR35(1), GPR50(2), GPR63(2), GPR83(1), GRIA1(4), GRIA2(2), GRIA3(6), GRIA4(2), GRID1(3), GRID2(2), GRIK1(4), GRIK3(2), GRIK4(2), GRIK5(5), GRIN2A(4), GRIN2B(3), GRIN2D(3), GRIN3A(3), GRIN3B(1), GRM1(3), GRM2(2), GRM3(2), GRM4(1), GRM5(5), GRM6(3), GRM7(3), GRM8(6), GRPR(4), GZMA(1), HCRTR1(1), HCRTR2(2), HRH1(2), HRH2(1), HRH4(2), HTR1A(4), HTR1B(2), HTR1D(1), HTR1F(2), HTR2B(2), HTR2C(2), HTR4(1), HTR5A(1), HTR6(3), HTR7(2), LEP(1), LEPR(8), LHCGR(1), MAS1(2), MC1R(1), MC2R(1), MC3R(1), MC5R(2), MCHR1(1), MCHR2(3), MLNR(3), MTNR1A(1), MTNR1B(2), NPBWR1(1), NPY1R(2), NPY2R(2), NPY5R(4), NR3C1(4), NTSR1(1), OPRL1(1), OPRM1(3), OXTR(3), P2RX1(1), P2RX2(3), P2RY1(1), P2RY10(1), P2RY13(3), P2RY14(1), P2RY4(3), P2RY8(2), PARD3(8), PRL(3), PRLHR(1), PRLR(1), PRSS1(2), PRSS3(2), PTAFR(1), PTGDR(2), PTGER3(2), PTGER4(2), PTGFR(1), PTH2R(1), RXFP1(3), RXFP2(2), SCTR(1), SSTR5(1), TAAR1(1), TAAR2(2), TAAR5(2), TACR1(1), TACR2(1), TBXA2R(1), THRA(1), VIPR2(1) 63414992 340 118 340 158 163 23 101 28 25 0 0.844 1.000 1.000 395 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(1), BID(1), BRAF(2), CASP3(1), CD244(2), CD247(1), FAS(5), FASLG(1), FCER1G(1), FYN(3), GZMB(1), HLA-A(17), HLA-B(11), HLA-C(5), HLA-E(2), HLA-G(2), HRAS(1), ICAM2(1), IFNA10(1), IFNA4(1), IFNA5(1), IFNA6(1), IFNA8(1), IFNAR1(3), IFNAR2(2), IFNG(1), IFNGR1(6), IFNGR2(3), ITGAL(4), KIR2DL1(1), KIR2DL3(1), KIR3DL1(1), KIR3DL2(1), KLRD1(2), KRAS(11), LAT(1), LCP2(1), MAP2K1(2), MAPK1(9), MAPK3(1), MICA(2), NCR1(1), NCR2(3), NCR3(1), NFAT5(5), NFATC1(4), NFATC2(4), NFATC3(5), NFATC4(3), NRAS(1), PAK1(1), PIK3CA(58), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(10), PIK3R3(4), PLCG1(3), PLCG2(4), PPP3CA(1), PPP3CC(1), PRF1(1), PRKCA(3), PRKCG(1), PTK2B(3), RAC1(1), RAC2(1), RAC3(1), SH3BP2(1), SHC2(3), SHC3(1), SOS1(5), SOS2(5), SYK(1), TNFRSF10A(1), TNFRSF10B(1), TNFRSF10C(1), TNFRSF10D(1), TNFSF10(2), TYROBP(1), ULBP1(1), ULBP2(1), ULBP3(1), VAV1(2), VAV2(3), VAV3(3), ZAP70(2) 32619146 275 117 216 60 151 10 53 17 42 2 0.00263 1.000 1.000 396 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(3), CD36(2), CD44(2), COL11A1(11), COL11A2(5), COL1A1(2), COL1A2(3), COL2A1(7), COL3A1(5), COL4A1(4), COL4A2(4), COL4A4(2), COL4A6(4), COL5A1(6), COL5A2(6), COL5A3(3), COL6A1(3), COL6A2(4), COL6A3(10), COL6A6(6), DAG1(3), FN1(5), FNDC1(7), FNDC3A(1), FNDC4(1), GP5(1), GP9(1), HMMR(3), HSPG2(13), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(3), ITGA2B(1), ITGA3(1), ITGA4(6), ITGA5(2), ITGA7(4), ITGA8(5), ITGA9(2), ITGAV(1), ITGB1(2), ITGB3(3), ITGB4(7), ITGB5(1), ITGB6(2), ITGB7(1), ITGB8(2), LAMA1(7), LAMA2(11), LAMA3(4), LAMA4(5), LAMA5(8), LAMB1(2), LAMB2(6), LAMB3(4), LAMB4(1), LAMC1(4), LAMC2(3), LAMC3(4), RELN(7), SDC1(1), SPP1(3), SV2B(1), SV2C(3), THBS1(2), THBS2(2), THBS3(2), THBS4(1), TNC(9), TNN(1), TNXB(7), VWF(6) 65230014 282 110 281 103 139 12 68 22 41 0 0.975 1.000 1.000 397 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(4), ADCY2(3), ADCY3(1), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(4), ADCY9(8), CALM1(2), CALM3(1), CALML6(1), CAMK2A(3), CAMK2B(1), CAMK2D(2), CREB1(2), CREB3(1), CREB3L1(1), CREB3L2(1), CREB3L3(3), CREB3L4(2), CREBBP(15), CTNNB1(5), DCT(2), EDN1(1), EDNRB(2), EP300(23), FZD1(1), FZD10(2), FZD2(2), FZD3(1), FZD4(3), FZD5(2), FZD6(2), FZD7(1), FZD8(1), GNAI1(1), GNAI2(1), GNAI3(3), GNAO1(1), GNAQ(2), GNAS(6), HRAS(1), KIT(3), KITLG(1), KRAS(11), LEF1(1), MAP2K1(2), MAPK1(9), MAPK3(1), MC1R(1), NRAS(1), PLCB1(10), PLCB2(2), PLCB3(2), PLCB4(1), POMC(2), PRKACA(2), PRKCA(3), PRKCG(1), TCF7L1(2), TCF7L2(2), TYR(2), WNT1(1), WNT10A(1), WNT11(1), WNT16(1), WNT2B(1), WNT5B(2), WNT7B(4), WNT8A(1), WNT8B(3) 31127487 206 109 188 57 111 5 56 11 19 4 0.0341 1.000 1.000 398 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(8), ACTN1(1), ACTR2(1), AKT1(3), AKT2(1), AKT3(3), ARHGEF6(1), ARHGEF7(4), BRAF(2), CDC42(1), CDKN2A(4), CRK(1), CSE1L(3), DOCK1(4), EPHB2(3), FYN(3), GRB7(3), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(3), ITGA3(1), ITGA4(6), ITGA5(2), ITGA7(4), ITGA8(5), ITGA9(2), MAP2K7(1), MAPK1(9), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(2), MAPK9(4), MRAS(1), MYLK(2), P4HB(2), PAK1(1), PAK2(1), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PIK3CA(58), PIK3CB(2), PKLR(3), PLCG1(3), PLCG2(4), PTEN(17), PTK2(2), RALA(1), ROCK1(3), ROCK2(4), SOS1(5), SOS2(5), TLN1(3), TLN2(1), VASP(1), ZYX(1) 35622808 224 108 176 66 141 7 35 13 28 0 0.359 1.000 1.000 399 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(8), ABL2(1), AKT1(3), AKT2(1), AKT3(3), ARAF(1), BAD(2), BRAF(2), BTC(1), CAMK2A(3), CAMK2B(1), CAMK2D(2), CBL(1), CBLB(5), CBLC(3), CDKN1A(1), CRK(1), EGF(1), EGFR(7), ELK1(2), ERBB2(11), ERBB3(12), ERBB4(4), GAB1(2), HRAS(1), JUN(2), KRAS(11), MAP2K1(2), MAP2K7(1), MAPK1(9), MAPK3(1), MAPK8(1), MAPK9(4), MYC(1), NCK1(2), NRAS(1), NRG1(1), NRG2(1), NRG3(3), NRG4(1), PAK1(1), PAK2(1), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PIK3CA(58), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(10), PIK3R3(4), PLCG1(3), PLCG2(4), PRKCA(3), PRKCG(1), PTK2(2), RPS6KB1(1), RPS6KB2(1), SHC2(3), SHC3(1), SOS1(5), SOS2(5), STAT5A(2), STAT5B(1) 29775923 238 107 180 49 138 5 63 19 13 0 0.00266 1.000 1.000 400 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 109 ACTN1(1), ACTN2(2), ACTN4(2), ARHGAP5(4), CD99(1), CDC42(1), CDH5(1), CLDN10(1), CLDN16(2), CLDN18(2), CLDN2(2), CLDN22(1), CLDN8(1), CTNNA1(2), CTNNA2(4), CTNNA3(6), CTNNB1(5), CTNND1(4), CXCR4(3), CYBB(2), EZR(6), F11R(2), GNAI1(1), GNAI2(1), GNAI3(3), ITGA4(6), ITGAL(4), ITGAM(4), ITGB1(2), ITK(1), MAPK11(2), MAPK13(1), MLLT4(5), MMP2(6), MMP9(1), MSN(2), MYL5(1), MYL9(1), MYLPF(1), NCF2(2), NCF4(2), NOX1(2), NOX3(4), OCLN(1), PIK3CA(58), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(10), PIK3R3(4), PLCG1(3), PLCG2(4), PRKCA(3), PRKCG(1), PTK2(2), PTK2B(3), PXN(2), RAC1(1), RAC2(1), RAP1A(1), RAP1B(1), RAPGEF3(1), RAPGEF4(4), RHOA(2), RHOH(1), ROCK1(3), ROCK2(4), SIPA1(2), THY1(1), TXK(2), VASP(1), VAV1(2), VAV2(3), VAV3(3), VCAM1(2), VCL(3) 36347430 240 106 200 61 143 9 51 20 17 0 0.0332 1.000 1.000 401 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 249 ACVR1B(2), ACVR2A(6), AMHR2(1), BMPR1A(1), BMPR1B(2), BMPR2(3), CCL15(1), CCL17(1), CCL23(2), CCR1(3), CCR2(1), CCR3(1), CCR4(2), CCR6(1), CCR7(1), CCR8(2), CCR9(2), CD27(2), CD40(1), CD40LG(3), CD70(2), CLCF1(1), CNTF(2), CRLF2(1), CSF1R(2), CSF2RB(2), CSF3R(3), CX3CL1(3), CX3CR1(2), CXCL16(1), CXCL9(1), CXCR3(1), CXCR4(3), CXCR6(1), EDAR(2), EGF(1), EGFR(7), EPOR(1), FAS(5), FASLG(1), FLT1(7), FLT3(3), FLT4(7), GDF5(5), GH2(1), GHR(6), HGF(5), IFNA10(1), IFNA4(1), IFNA5(1), IFNA6(1), IFNA8(1), IFNAR1(3), IFNAR2(2), IFNG(1), IFNGR1(6), IFNGR2(3), IL11(1), IL11RA(2), IL12A(2), IL12B(2), IL12RB1(1), IL12RB2(2), IL15(2), IL15RA(1), IL17A(1), IL17RB(1), IL18R1(2), IL18RAP(2), IL19(1), IL1A(2), IL1R1(2), IL1R2(2), IL1RAP(5), IL20(1), IL20RA(1), IL21(1), IL21R(1), IL22RA1(1), IL23A(1), IL23R(1), IL26(1), IL3RA(2), IL4R(5), IL5(1), IL5RA(2), IL6(1), IL6R(3), IL6ST(2), IL8(2), IL9R(3), INHBA(1), INHBB(1), INHBC(1), INHBE(1), KDR(2), KIT(3), KITLG(1), LEP(1), LEPR(8), LIFR(2), LTBR(1), MET(2), MPL(1), NGFR(1), OSMR(1), PDGFC(1), PDGFRA(2), PDGFRB(2), PLEKHO2(4), PPBP(1), PRL(3), PRLR(1), TGFB2(1), TGFB3(2), TGFBR1(1), TGFBR2(5), TNFRSF10A(1), TNFRSF10B(1), TNFRSF10C(1), TNFRSF10D(1), TNFRSF11B(1), TNFRSF12A(1), TNFRSF13B(1), TNFRSF14(1), TNFRSF1A(4), TNFRSF1B(2), TNFRSF21(2), TNFRSF6B(1), TNFRSF8(3), TNFSF10(2), TNFSF11(1), TNFSF13B(1), TPO(6), VEGFA(1), VEGFC(4), XCL1(1), XCL2(1), XCR1(4) 51353016 285 105 279 93 145 21 51 20 48 0 0.405 1.000 1.000 402 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 142 APC(7), AXIN2(2), BTRC(1), CAMK2A(3), CAMK2B(1), CAMK2D(2), CCND1(1), CHD8(10), CREBBP(15), CTBP1(1), CTBP2(3), CTNNB1(5), CTNNBIP1(3), CUL1(4), DAAM1(3), DAAM2(4), DKK1(1), EP300(23), FBXW11(1), FZD1(1), FZD10(2), FZD2(2), FZD3(1), FZD4(3), FZD5(2), FZD6(2), FZD7(1), FZD8(1), JUN(2), LEF1(1), LRP5(8), LRP6(7), MAPK8(1), MAPK9(4), MMP7(1), MYC(1), NFAT5(5), NFATC1(4), NFATC2(4), NFATC3(5), NFATC4(3), NKD1(1), NKD2(1), PLCB1(10), PLCB2(2), PLCB3(2), PLCB4(1), PORCN(3), PPARD(2), PPP2R1A(2), PPP2R2A(3), PPP2R2B(3), PPP2R2C(3), PPP3CA(1), PPP3CC(1), PRICKLE2(1), PRKACA(2), PRKCA(3), PRKCG(1), PSEN1(4), RAC1(1), RAC2(1), RAC3(1), RBX1(1), RHOA(2), ROCK1(3), ROCK2(4), RUVBL1(2), SENP2(1), SFRP2(1), SFRP4(1), SMAD2(1), SMAD3(2), SMAD4(7), SOX17(2), TBL1X(1), TBL1XR1(5), TCF7L1(2), TCF7L2(2), TP53(12), VANGL2(1), WIF1(1), WNT1(1), WNT10A(1), WNT11(1), WNT16(1), WNT2B(1), WNT5B(2), WNT7B(4), WNT8A(1), WNT8B(3) 45826814 266 105 257 87 143 9 58 17 35 4 0.712 1.000 1.000 403 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM1(2), CALM3(1), CALML6(1), DGKA(3), DGKB(1), DGKE(1), DGKG(3), DGKH(2), DGKI(4), DGKQ(1), DGKZ(5), IMPA2(2), INPP1(2), INPP4A(3), INPP4B(4), INPP5B(2), INPP5D(4), INPP5E(1), INPPL1(4), ITPK1(1), ITPKA(1), ITPKB(1), ITPR1(8), ITPR2(5), ITPR3(2), OCRL(3), PI4KA(5), PI4KB(1), PIK3C2A(4), PIK3C2B(4), PIK3C2G(5), PIK3C3(4), PIK3CA(58), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(10), PIK3R3(4), PIP4K2A(1), PIP5K1A(1), PIP5K1B(1), PIP5K1C(3), PLCB1(10), PLCB2(2), PLCB3(2), PLCB4(1), PLCD1(2), PLCD3(3), PLCD4(2), PLCE1(9), PLCG1(3), PLCG2(4), PLCZ1(3), PRKCA(3), PRKCG(1), PTEN(17), SYNJ1(2), SYNJ2(1) 36907339 237 104 196 55 145 7 36 20 29 0 0.0111 1.000 1.000 404 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 108 ABL1(8), ANAPC1(2), ANAPC2(4), ANAPC5(1), ANAPC7(1), ATM(11), ATR(6), BUB1(4), BUB1B(1), CCNA1(2), CCNA2(2), CCNB3(4), CCND1(1), CDC14A(3), CDC14B(3), CDC16(1), CDC20(2), CDC25A(2), CDC25B(4), CDC25C(2), CDC27(3), CDC6(1), CDC7(2), CDK2(1), CDKN1A(1), CDKN2A(4), CHEK1(1), CHEK2(1), CREBBP(15), CUL1(4), DBF4(1), E2F2(1), E2F3(3), EP300(23), ESPL1(5), FZR1(2), GADD45B(1), MCM2(1), MCM5(2), MCM6(1), MCM7(3), MDM2(1), PCNA(1), PKMYT1(1), PLK1(1), PRKDC(11), PTTG2(1), RB1(9), RBL1(3), RBL2(2), RBX1(1), SFN(1), SMAD2(1), SMAD3(2), SMAD4(7), SMC1A(4), SMC1B(2), TFDP1(2), TGFB2(1), TGFB3(2), TP53(12), YWHAE(2), YWHAQ(2), YWHAZ(3) 39939316 212 104 204 54 120 8 28 12 39 5 0.326 1.000 1.000 405 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(2), ACTB(2), ACTG1(5), ACTN1(1), ACTN2(2), ACTN4(2), ACVR1B(2), ACVR1C(1), CDC42(1), CDH1(2), CREBBP(15), CTNNA1(2), CTNNA2(4), CTNNA3(6), CTNNB1(5), CTNND1(4), EGFR(7), EP300(23), ERBB2(11), FARP2(3), FER(3), FGFR1(1), FYN(3), IGF1R(3), INSR(4), IQGAP1(10), LEF1(1), LMO7(8), MAPK1(9), MAPK3(1), MET(2), MLLT4(5), PARD3(8), PTPN1(1), PTPRB(5), PTPRF(7), PTPRJ(1), PTPRM(6), PVRL1(3), PVRL2(1), PVRL3(5), RAC1(1), RAC2(1), RAC3(1), RHOA(2), SMAD2(1), SMAD3(2), SMAD4(7), SNAI1(2), SORBS1(5), SSX2IP(1), TCF7L1(2), TCF7L2(2), TGFBR1(1), TGFBR2(5), TJP1(7), VCL(3), WASF1(3), WASF2(2), WASF3(1), WASL(4), YES1(2) 35102252 242 103 227 63 136 9 38 10 45 4 0.166 1.000 1.000 406 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 99 AKT1(3), AKT2(1), AKT3(3), CASP8(9), CD14(3), CD40(1), CHUK(2), CXCL9(1), FADD(1), FOS(2), IFNA10(1), IFNA4(1), IFNA5(1), IFNA6(1), IFNA8(1), IFNAR1(3), IFNAR2(2), IKBKB(2), IKBKE(1), IL12A(2), IL12B(2), IL6(1), IL8(2), IRAK1(3), IRF5(2), IRF7(3), JUN(2), LY96(2), MAP2K1(2), MAP2K3(2), MAP2K7(1), MAP3K8(1), MAPK1(9), MAPK11(2), MAPK13(1), MAPK3(1), MAPK8(1), MAPK9(4), NFKB1(2), NFKB2(1), NFKBIA(2), PIK3CA(58), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(10), PIK3R3(4), RAC1(1), RELA(7), RIPK1(2), SPP1(3), STAT1(2), TBK1(3), TICAM1(4), TLR1(1), TLR2(2), TLR3(5), TLR4(2), TLR5(2), TLR7(4), TLR8(4), TLR9(2), TOLLIP(1), TRAF3(3), TRAF6(1) 25933057 212 101 164 41 137 8 31 15 21 0 0.000687 1.000 1.000 407 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(4), ADCY2(3), ADCY3(1), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(4), ADCY9(8), CSNK1D(2), EGF(1), EGFR(7), GJA1(2), GJD2(2), GNA11(2), GNAI1(1), GNAI2(1), GNAI3(3), GNAQ(2), GNAS(6), GRM1(3), GRM5(5), GUCY1A2(4), GUCY1A3(3), GUCY1B3(2), GUCY2C(1), GUCY2D(3), GUCY2F(5), HRAS(1), HTR2B(2), HTR2C(2), ITPR1(8), ITPR2(5), ITPR3(2), KRAS(11), MAP2K1(2), MAP3K2(1), MAPK1(9), MAPK3(1), MAPK7(2), NPR1(2), NRAS(1), PDGFC(1), PDGFRA(2), PDGFRB(2), PLCB1(10), PLCB2(2), PLCB3(2), PLCB4(1), PRKACA(2), PRKCA(3), PRKCG(1), PRKG2(3), SOS1(5), SOS2(5), TJP1(7), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3C(2), TUBA3D(1), TUBA8(2), TUBB(1), TUBB8(1) 38465170 195 100 183 85 110 8 56 11 10 0 0.936 1.000 1.000 408 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 93 AKT1(3), AKT2(1), AKT3(3), CARD11(5), CBL(1), CBLB(5), CBLC(3), CD247(1), CD3D(2), CD4(1), CD40LG(3), CD8A(2), CD8B(1), CDC42(1), CHUK(2), FOS(2), FYN(3), HRAS(1), IFNG(1), IKBKB(2), IL5(1), ITK(1), JUN(2), KRAS(11), LAT(1), LCP2(1), MALT1(1), MAP3K8(1), NCK1(2), NFAT5(5), NFATC1(4), NFATC2(4), NFATC3(5), NFATC4(3), NFKB1(2), NFKB2(1), NFKBIA(2), NFKBIE(2), NRAS(1), PAK1(1), PAK2(1), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PDK1(3), PIK3CA(58), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(10), PIK3R3(4), PLCG1(3), PPP3CA(1), PPP3CC(1), PRKCQ(1), PTPRC(10), RASGRP1(1), RHOA(2), SOS1(5), SOS2(5), VAV1(2), VAV2(3), VAV3(3), ZAP70(2) 29264279 221 100 175 54 139 8 44 15 15 0 0.0795 1.000 1.000 409 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(4), ADCY2(3), ADCY3(1), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(4), ADCY9(8), ADRA1A(3), ADRA1B(2), ADRA1D(1), ADRB2(2), ARRB1(2), ATP1A4(2), ATP1B1(1), ATP1B3(1), ATP2A2(3), ATP2A3(3), ATP2B1(3), ATP2B2(5), ATP2B3(3), CACNA1A(4), CACNA1B(9), CACNA1C(9), CACNA1D(4), CACNA1E(6), CACNA1S(3), CACNB1(2), CACNB3(2), CALM1(2), CALM3(1), CALR(3), CAMK1(2), CAMK2A(3), CAMK2B(1), CAMK2D(2), CAMK4(2), CASQ1(2), CHRM1(1), CHRM2(3), CHRM3(3), CHRM4(1), CHRM5(1), GJA1(2), GJA5(1), GJB1(1), GJB5(1), GJB6(1), GNA11(2), GNAI2(1), GNAI3(3), GNAO1(1), GNAQ(2), GNB1(1), GNB2(1), GNB3(1), GNB5(4), GNG2(1), GNGT1(1), GRK4(3), GRK5(2), GRK6(1), ITPR1(8), ITPR2(5), ITPR3(2), KCNB1(1), KCNJ5(1), MIB1(2), MYCBP(1), NME7(1), PKIA(1), PKIB(1), PLCB3(2), PRKACA(2), PRKAR2A(1), PRKCA(3), PRKCD(1), PRKCE(1), PRKCG(1), PRKCH(1), PRKCQ(1), PRKCZ(1), PRKD1(4), RGS10(2), RGS11(1), RGS14(3), RGS17(3), RGS18(1), RGS19(1), RGS2(2), RGS20(1), RGS3(8), RGS4(3), RGS5(1), RGS7(2), RGS9(1), RYR1(10), RYR2(26), RYR3(11), SFN(1), SLC8A1(1), YWHAQ(2) 56070717 282 99 282 114 155 10 72 20 25 0 0.719 1.000 1.000 410 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 62 AKT1(3), AKT2(1), AKT3(3), BAD(2), CDC42(1), CDK2(1), CDKN2A(4), CREB1(2), CREB3(1), CREB5(5), ERBB4(4), F2RL2(1), GAB1(2), GSK3A(3), INPPL1(4), IRS1(2), IRS4(2), MET(2), MYC(1), NOLC1(2), PAK1(1), PAK2(1), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PARD3(8), PARD6A(1), PDK1(3), PIK3CA(58), PIK3CD(1), PPP1R13B(2), PREX1(10), PTEN(17), PTK2(2), PTPN1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), SFN(1), SOS1(5), SOS2(5), TSC1(2), TSC2(6), YWHAE(2), YWHAQ(2), YWHAZ(3) 21882076 191 98 149 39 122 5 26 15 23 0 0.0108 1.000 1.000 411 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 128 ALCAM(2), CADM1(2), CADM3(1), CD22(3), CD226(3), CD274(1), CD34(2), CD4(1), CD40(1), CD40LG(3), CD58(2), CD6(2), CD8A(2), CD8B(1), CD99(1), CDH1(2), CDH15(2), CDH2(1), CDH4(2), CDH5(1), CLDN10(1), CLDN16(2), CLDN18(2), CLDN2(2), CLDN22(1), CLDN8(1), CNTN1(4), CNTN2(1), CNTNAP1(5), CNTNAP2(8), F11R(2), GLG1(5), HLA-A(17), HLA-B(11), HLA-C(5), HLA-DMA(2), HLA-DMB(2), HLA-DPB1(3), HLA-DQA1(3), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(1), HLA-E(2), HLA-F(2), HLA-G(2), ICAM2(1), ICAM3(4), ICOSLG(2), ITGA4(6), ITGA8(5), ITGA9(2), ITGAL(4), ITGAM(4), ITGAV(1), ITGB1(2), ITGB7(1), ITGB8(2), L1CAM(5), MADCAM1(3), MAG(1), MPZ(1), MPZL1(1), NCAM1(4), NCAM2(5), NEGR1(1), NEO1(4), NFASC(4), NLGN1(4), NLGN3(4), NRCAM(5), NRXN1(4), NRXN2(2), NRXN3(4), OCLN(1), PDCD1LG2(1), PTPRC(10), PTPRF(7), PTPRM(6), PVR(1), PVRL1(3), PVRL2(1), PVRL3(5), SDC1(1), SELE(1), SELL(1), SIGLEC1(5), SPN(1), VCAM1(2), VCAN(15) 41652055 270 97 261 85 124 13 49 22 60 2 0.447 1.000 1.000 412 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(4), ADCY2(3), ADCY3(1), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(4), ADCY9(8), ATF4(2), CACNA1C(9), CACNA1D(4), CACNA1F(6), CACNA1S(3), CALM1(2), CALM3(1), CALML6(1), CAMK2A(3), CAMK2B(1), CAMK2D(2), CDC42(1), CGA(1), EGFR(7), ELK1(2), GNA11(2), GNAQ(2), GNAS(6), GNRH2(1), HRAS(1), ITPR1(8), ITPR2(5), ITPR3(2), JUN(2), KRAS(11), MAP2K1(2), MAP2K3(2), MAP2K7(1), MAP3K1(4), MAP3K2(1), MAP3K3(1), MAP3K4(6), MAPK1(9), MAPK11(2), MAPK13(1), MAPK3(1), MAPK7(2), MAPK8(1), MAPK9(4), MMP2(6), NRAS(1), PLA2G12A(1), PLA2G12B(3), PLA2G2D(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLCB1(10), PLCB2(2), PLCB3(2), PLCB4(1), PLD1(3), PRKACA(2), PRKCA(3), PRKCD(1), PTK2B(3), SOS1(5), SOS2(5) 37888894 211 97 199 79 121 8 56 16 10 0 0.635 1.000 1.000 413 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(1), ACTN2(2), ACTN4(2), DMD(23), MYBPC1(3), MYBPC2(6), MYBPC3(1), MYH3(8), MYH6(6), MYH7(8), MYH8(7), MYL1(2), MYL3(2), MYL9(1), MYOM1(2), NEB(24), TMOD1(1), TNNT2(2), TPM2(3), TPM4(1), TTN(136), VIM(1) 41041892 242 97 242 78 144 14 46 15 21 2 0.888 1.000 1.000 414 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(3), AKT2(1), AKT3(3), BTK(4), FCER1G(1), FYN(3), GAB2(1), HRAS(1), IL5(1), INPP5D(4), KRAS(11), LAT(1), LCP2(1), MAP2K1(2), MAP2K3(2), MAP2K7(1), MAPK1(9), MAPK11(2), MAPK13(1), MAPK3(1), MAPK8(1), MAPK9(4), MS4A2(1), NRAS(1), PDK1(3), PIK3CA(58), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(10), PIK3R3(4), PLA2G12A(1), PLA2G12B(3), PLA2G2D(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLCG1(3), PLCG2(4), PRKCA(3), PRKCD(1), PRKCE(1), RAC1(1), RAC2(1), RAC3(1), SOS1(5), SOS2(5), SYK(1), VAV1(2), VAV2(3), VAV3(3) 20994451 184 96 132 36 115 5 40 17 7 0 0.00165 1.000 1.000 415 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(3), AKT2(1), AKT3(3), BRAF(2), DDIT4(1), EIF4B(3), FIGF(1), HIF1A(5), MAPK1(9), MAPK3(1), PDPK1(2), PIK3CA(58), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(10), PIK3R3(4), PRKAA2(3), RICTOR(4), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA6(6), RPS6KB1(1), RPS6KB2(1), STK11(8), TSC1(2), TSC2(6), ULK1(2), ULK2(3), VEGFA(1), VEGFC(4) 15606986 153 95 106 33 107 7 21 10 8 0 0.0516 1.000 1.000 416 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 141 ADA(2), ADCY1(4), ADCY2(3), ADCY3(1), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(4), ADCY9(8), ADSS(1), ADSSL1(2), AK2(1), AK5(1), AK7(5), ALLC(2), AMPD1(2), AMPD2(2), APRT(1), CANT1(1), DCK(1), DGUOK(2), ENPP1(2), ENPP3(5), ENTPD3(2), ENTPD4(1), GART(1), GDA(3), GMPR(1), GMPS(2), GUCY1A2(4), GUCY1A3(3), GUCY1B3(2), GUCY2C(1), GUCY2D(3), GUCY2F(5), GUK1(1), HPRT1(1), IMPDH1(2), IMPDH2(1), NME6(1), NME7(1), NPR1(2), NT5C(2), NT5C1A(2), NT5C1B(2), NT5C2(3), NT5E(1), NUDT9(1), PAICS(1), PAPSS1(1), PAPSS2(2), PDE10A(2), PDE11A(2), PDE1A(3), PDE1C(6), PDE2A(2), PDE4A(3), PDE4B(5), PDE5A(4), PDE6D(2), PDE7B(1), PDE8A(1), PDE8B(1), PDE9A(1), PFAS(2), PKLR(3), PNPT1(1), POLA1(5), POLA2(1), POLD1(3), POLD2(1), POLD3(1), POLE(7), POLR1A(7), POLR1B(3), POLR1C(3), POLR2A(5), POLR2B(3), POLR2C(1), POLR2F(1), POLR2H(1), POLR2L(1), POLR3A(1), POLR3B(3), POLR3G(2), PPAT(1), PRIM1(1), PRPS2(2), PRUNE(1), RFC5(2), RRM1(2), RRM2B(1), XDH(2) 47921728 216 94 216 90 121 10 51 16 18 0 0.966 1.000 1.000 417 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 81 AIFM1(2), AKT1(3), AKT2(1), AKT3(3), APAF1(3), ATM(11), BAD(2), BID(1), BIRC2(2), BIRC3(1), CAPN1(5), CASP10(1), CASP3(1), CASP6(2), CASP8(9), CASP9(1), CHUK(2), CSF2RB(2), DFFA(1), DFFB(1), FADD(1), FAS(5), FASLG(1), IKBKB(2), IL1A(2), IL1R1(2), IL1RAP(5), IL3RA(2), IRAK1(3), IRAK2(1), IRAK3(2), NFKB1(2), NFKB2(1), NFKBIA(2), PIK3CA(58), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(10), PIK3R3(4), PPP3CA(1), PPP3CC(1), PRKACA(2), PRKAR2A(1), RELA(7), RIPK1(2), TNFRSF10A(1), TNFRSF10B(1), TNFRSF10C(1), TNFRSF10D(1), TNFRSF1A(4), TNFSF10(2), TP53(12), TRAF2(1) 24527987 198 94 153 45 124 8 26 16 24 0 0.0326 1.000 1.000 418 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 86 ACVR1B(2), ACVR1C(1), ACVR2A(6), ACVRL1(1), AMHR2(1), BMP4(2), BMP5(1), BMP6(1), BMP8A(1), BMPR1A(1), BMPR1B(2), BMPR2(3), CHRD(3), COMP(3), CREBBP(15), CUL1(4), E2F4(1), E2F5(1), EP300(23), GDF5(5), GDF6(2), GDF7(1), ID1(1), ID4(1), IFNG(1), INHBA(1), INHBB(1), INHBC(1), INHBE(1), LEFTY1(1), LEFTY2(2), LTBP1(2), MAPK1(9), MAPK3(1), MYC(1), NODAL(2), PITX2(2), PPP2R1A(2), PPP2R2A(3), PPP2R2B(3), PPP2R2C(3), RBL1(3), RBL2(2), RBX1(1), RHOA(2), ROCK1(3), ROCK2(4), RPS6KB1(1), RPS6KB2(1), SMAD1(1), SMAD2(1), SMAD3(2), SMAD4(7), SMAD5(3), SMAD7(1), SMURF2(2), SP1(3), TFDP1(2), TGFB2(1), TGFB3(2), TGFBR1(1), TGFBR2(5), THBS1(2), THBS2(2), THBS3(2), THBS4(1), ZFYVE16(4), ZFYVE9(4) 28258572 181 94 169 47 91 12 31 13 30 4 0.303 1.000 1.000 419 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 63 AKT1(3), AKT2(1), AKT3(3), BLNK(2), BTK(4), CARD11(5), CD19(1), CD22(3), CD72(1), CD79A(1), CD79B(1), CHUK(2), CR2(3), FOS(2), HRAS(1), IKBKB(2), INPP5D(4), JUN(2), KRAS(11), LILRB3(3), MALT1(1), NFAT5(5), NFATC1(4), NFATC2(4), NFATC3(5), NFATC4(3), NFKB1(2), NFKB2(1), NFKBIA(2), NFKBIE(2), NRAS(1), PIK3CA(58), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(10), PIK3R3(4), PLCG2(4), PPP3CA(1), PPP3CC(1), RAC1(1), RAC2(1), RAC3(1), SYK(1), VAV1(2), VAV2(3), VAV3(3) 21687714 179 94 133 38 109 5 41 13 11 0 0.0122 1.000 1.000 420 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1B(2), ACVRL1(1), AKT1(3), AURKB(2), BMPR1A(1), BMPR2(3), BUB1(4), CDKL2(2), CLK1(4), CLK2(3), CLK4(2), COL4A3BP(3), DGKA(3), DGKB(1), DGKE(1), DGKG(3), DGKH(2), DGKQ(1), DGKZ(5), INPP1(2), INPP4A(3), INPP4B(4), INPPL1(4), ITPKA(1), ITPKB(1), MAP3K10(2), NEK1(2), NEK3(1), OCRL(3), PAK4(2), PIK3C2A(4), PIK3C2B(4), PIK3C2G(5), PIK3CA(58), PIK3CB(2), PIK3CG(1), PIM2(1), PLCB1(10), PLCB2(2), PLCB3(2), PLCB4(1), PLCD1(2), PLCG1(3), PLCG2(4), PLK3(1), PRKACA(2), PRKAR2A(1), PRKCA(3), PRKCD(1), PRKCE(1), PRKCG(1), PRKCH(1), PRKCQ(1), PRKCZ(1), PRKD1(4), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA4(1), RPS6KB1(1), STK11(8), TGFBR1(1) 33362595 203 94 163 53 130 8 36 20 9 0 0.126 1.000 1.000 421 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(3), AKT2(1), AKT3(3), BAD(2), CASP9(1), CDC42(1), HRAS(1), KDR(2), KRAS(11), MAP2K1(2), MAPK1(9), MAPK11(2), MAPK13(1), MAPK3(1), MAPKAPK2(2), MAPKAPK3(1), NFAT5(5), NFATC1(4), NFATC2(4), NFATC3(5), NFATC4(3), NOS3(6), NRAS(1), PIK3CA(58), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIK3R1(10), PIK3R3(4), PLA2G12A(1), PLA2G12B(3), PLA2G2D(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLCG1(3), PLCG2(4), PPP3CA(1), PPP3CC(1), PRKCA(3), PRKCG(1), PTGS2(2), PTK2(2), PXN(2), RAC1(1), RAC2(1), RAC3(1), SHC2(3), SPHK1(1), SPHK2(1), VEGFA(1) 20976128 186 93 134 38 116 5 42 13 10 0 0.00247 1.000 1.000 422 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(4), ADCY8(4), ARAF(1), ATF4(2), BRAF(2), CACNA1C(9), CALM1(2), CALM3(1), CALML6(1), CAMK2A(3), CAMK2B(1), CAMK2D(2), CAMK4(2), CREBBP(15), EP300(23), GNAQ(2), GRIA1(4), GRIA2(2), GRIN2A(4), GRIN2B(3), GRIN2D(3), GRM1(3), GRM5(5), HRAS(1), ITPR1(8), ITPR2(5), ITPR3(2), KRAS(11), MAP2K1(2), MAPK1(9), MAPK3(1), NRAS(1), PLCB1(10), PLCB2(2), PLCB3(2), PLCB4(1), PPP1CB(2), PPP1CC(1), PPP1R12A(7), PPP1R1A(1), PPP3CA(1), PPP3CC(1), PRKACA(2), PRKCA(3), PRKCG(1), RAP1A(1), RAP1B(1), RAPGEF3(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA6(6) 29793882 186 92 169 66 99 8 44 12 19 4 0.620 1.000 1.000 423 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 136 ACTA1(1), ADCY1(4), ADCY2(3), ADCY3(1), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(4), ADCY9(8), ARRB1(2), ATF2(2), ATF4(2), ATF5(1), ATP2A2(3), ATP2A3(3), CACNB3(2), CALM1(2), CALM3(1), CAMK2A(3), CAMK2B(1), CAMK2D(2), CNN2(1), CORIN(3), CREB3(1), CRHR1(2), DGKZ(5), ETS2(1), FOS(2), GABPB2(1), GBA2(1), GJA1(2), GNAQ(2), GNB1(1), GNB2(1), GNB3(1), GNB5(4), GNG2(1), GNGT1(1), GRK4(3), GRK5(2), GRK6(1), GSTO1(1), GUCY1A3(3), IL6(1), ITPR1(8), ITPR2(5), ITPR3(2), JUN(2), MIB1(2), NFKB1(2), NOS1(2), NOS3(6), OXTR(3), PDE4B(5), PKIA(1), PKIB(1), PLCB3(2), PLCD1(2), PLCG1(3), PLCG2(4), PRKACA(2), PRKAR2A(1), PRKCA(3), PRKCD(1), PRKCE(1), PRKCH(1), PRKCQ(1), PRKCZ(1), PRKD1(4), RAMP2(3), RGS10(2), RGS11(1), RGS14(3), RGS17(3), RGS18(1), RGS19(1), RGS2(2), RGS20(1), RGS3(8), RGS4(3), RGS5(1), RGS7(2), RGS9(1), RLN1(1), RYR1(10), RYR2(26), RYR3(11), SFN(1), SLC8A1(1), SP1(3), TNXB(7), YWHAQ(2) 50377111 259 92 258 96 149 6 55 22 27 0 0.653 1.000 1.000 424 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 IMPA2(2), INPP1(2), INPP4A(3), INPP4B(4), INPP5B(2), INPP5E(1), INPPL1(4), IPMK(1), ISYNA1(1), ITPK1(1), ITPKA(1), ITPKB(1), MIOX(1), OCRL(3), PI4KA(5), PI4KB(1), PIK3C3(4), PIK3CA(58), PIK3CB(2), PIK3CD(1), PIK3CG(1), PIP4K2A(1), PIP5K1A(1), PIP5K1B(1), PIP5K1C(3), PLCB1(10), PLCB2(2), PLCB3(2), PLCB4(1), PLCD1(2), PLCD3(3), PLCD4(2), PLCE1(9), PLCG1(3), PLCG2(4), PLCZ1(3), PTEN(17), SYNJ1(2), SYNJ2(1) 21692423 166 91 125 34 104 4 19 17 22 0 0.00720 1.000 1.000 425 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(3), AKT2(1), AKT3(3), BAD(2), BCR(2), BLNK(2), BTK(4), CD19(1), CD22(3), CR2(3), DAG1(3), FLOT2(2), GSK3A(3), INPP5D(4), ITPR1(8), ITPR2(5), ITPR3(2), MAP4K1(3), MAPK1(9), MAPK3(1), NFATC1(4), NFATC2(4), PDK1(3), PIK3CA(58), PIK3CD(1), PIK3R1(10), PLCG2(4), PPP1R13B(2), PPP3CA(1), PPP3CC(1), PTPRC(10), SOS1(5), SOS2(5), SYK(1), VAV1(2) 21254151 175 91 129 35 112 7 25 16 15 0 0.00418 1.000 1.000 426 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(8), ATM(11), BUB1(4), BUB1B(1), CCNA1(2), CCNA2(2), CCNB3(4), CDC14A(3), CDC14B(3), CDC20(2), CDC25A(2), CDC25B(4), CDC25C(2), CDC6(1), CDC7(2), CDH1(2), CDK2(1), CDKN1A(1), CDKN2A(4), CHEK1(1), CHEK2(1), DTX4(1), E2F2(1), E2F3(3), E2F4(1), E2F5(1), E2F6(1), EP300(23), ESPL1(5), HDAC3(3), HDAC4(3), HDAC5(2), HDAC6(4), HDAC8(1), MCM2(1), MCM5(2), MCM6(1), MCM7(3), MDM2(1), MPEG1(2), MPL(1), PCNA(1), PLK1(1), PRKDC(11), PTPRA(2), PTTG2(1), RB1(9), RBL1(3), SMAD4(7), TBC1D8(1), TFDP1(2), TP53(12) 32542280 171 88 164 37 90 11 27 12 27 4 0.0489 1.000 1.000 427 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(4), ADCY2(3), ADCY3(1), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(4), ADCY9(8), AKAP1(1), AKAP10(2), AKAP11(5), AKAP12(5), AKAP2(1), AKAP3(6), AKAP4(4), AKAP5(1), AKAP6(6), AKAP7(3), AKAP8(3), AKAP9(3), ARHGEF1(1), CALM1(2), CALM3(1), GNA11(2), GNA12(2), GNA13(3), GNA15(4), GNAI2(1), GNAI3(3), GNAL(2), GNAO1(1), GNAQ(2), GNB1(1), GNB2(1), GNB3(1), GNB5(4), GNGT1(1), HRAS(1), ITPR1(8), KRAS(11), NRAS(1), PDE1A(3), PDE1B(2), PDE1C(6), PDE4A(3), PDE4B(5), PDE7B(1), PDE8A(1), PDE8B(1), PLCB3(2), PPP3CA(1), PPP3CC(1), PRKACA(2), PRKAR2A(1), PRKCA(3), PRKCD(1), PRKCE(1), PRKCG(1), PRKCH(1), PRKCI(6), PRKCQ(1), PRKCZ(1), PRKD1(4), PRKD3(1), RHOA(2), SLC9A1(4) 34190675 182 88 176 49 104 5 43 17 13 0 0.146 1.000 1.000 428 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(1), BRAF(2), CACNA1A(4), CRHR1(2), GNA11(2), GNA12(2), GNA13(3), GNAI1(1), GNAI2(1), GNAI3(3), GNAO1(1), GNAQ(2), GNAS(6), GRIA1(4), GRIA2(2), GRIA3(6), GRID2(2), GRM1(3), GRM5(5), GUCY1A2(4), GUCY1A3(3), GUCY1B3(2), GUCY2C(1), GUCY2D(3), GUCY2F(5), HRAS(1), IGF1R(3), ITPR1(8), ITPR2(5), ITPR3(2), KRAS(11), MAP2K1(2), MAPK1(9), MAPK3(1), NOS1(2), NOS3(6), NPR1(2), NRAS(1), PLA2G12A(1), PLA2G12B(3), PLA2G2D(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLCB1(10), PLCB2(2), PLCB3(2), PLCB4(1), PPP2R1A(2), PPP2R2A(3), PPP2R2B(3), PPP2R2C(3), PRKCA(3), PRKCG(1), PRKG2(3), RYR1(10) 32481159 177 87 165 69 92 7 48 15 15 0 0.782 1.000 1.000 429 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 159 ADORA1(1), ADORA3(3), ADRA1A(3), ADRA1B(2), ADRA1D(1), ADRA2C(1), ADRB2(2), AGTR1(1), AVPR1A(1), AVPR1B(2), AVPR2(2), BRS3(3), CCKAR(1), CCKBR(1), CCR1(3), CCR2(1), CCR3(1), CCR4(2), CCR6(1), CCR7(1), CCR8(2), CCR9(2), CCRL2(1), CHRM1(1), CHRM2(3), CHRM3(3), CHRM4(1), CHRM5(1), CMKLR1(4), CNR1(1), CNR2(1), CX3CR1(2), CXCR3(1), CXCR4(3), DRD3(2), EDNRA(1), EDNRB(2), F2R(1), F2RL2(1), F2RL3(2), FPR1(1), FSHR(2), GALR2(1), GALT(2), GHSR(2), GPR173(3), GPR174(2), GPR3(1), GPR35(1), GPR37(1), GPR50(2), GPR63(2), GPR83(1), GPR85(1), GRPR(4), HCRTR1(1), HCRTR2(2), HRH1(2), HRH2(1), HTR1A(4), HTR1B(2), HTR1D(1), HTR1F(2), HTR2B(2), HTR2C(2), HTR4(1), HTR5A(1), HTR6(3), HTR7(2), LHCGR(1), MAS1(2), MC1R(1), MC3R(1), MC5R(2), MLNR(3), MTNR1A(1), MTNR1B(2), NPY1R(2), NPY2R(2), NPY5R(4), NTSR1(1), OPN1SW(1), OPRL1(1), OPRM1(3), OR10A5(2), OR1C1(2), OR1Q1(2), OR7C1(1), OR8B8(2), OXTR(3), P2RY1(1), P2RY10(1), P2RY12(1), P2RY13(3), P2RY14(1), PTAFR(1), PTGDR(2), PTGER4(2), PTGFR(1), RGR(1), RRH(2), TBXA2R(1) 33804248 176 86 176 87 85 14 54 12 11 0 0.514 1.000 1.000 430 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(3), AKT3(3), CAPN1(5), CAPN3(5), CAPN6(2), CAPN9(3), CAPNS1(1), CAV2(1), CDC42(1), CRK(1), DOCK1(4), FYN(3), GIT2(2), ITGA10(2), ITGA11(3), ITGA2(3), ITGA2B(1), ITGA3(1), ITGA4(6), ITGA5(2), ITGA7(4), ITGA8(5), ITGA9(2), ITGAD(1), ITGAE(3), ITGAL(4), ITGAM(4), ITGAV(1), ITGAX(3), ITGB1(2), ITGB3(3), ITGB4(7), ITGB5(1), ITGB6(2), ITGB7(1), ITGB8(2), MAP2K1(2), MAP2K3(2), MAPK4(1), MAPK6(2), MAPK7(2), PAK1(1), PAK2(1), PAK3(1), PAK4(2), PAK6(3), PDPK1(2), PTK2(2), PXN(2), RAC1(1), RAC2(1), RAC3(1), RAP1B(1), RAPGEF1(4), ROCK1(3), ROCK2(4), SDCCAG8(4), SHC3(1), SORBS1(5), SOS1(5), TLN1(3), TNS1(5), VASP(1), VAV2(3), VAV3(3), VCL(3), ZYX(1) 39668168 169 86 168 73 92 11 36 6 24 0 0.975 1.000 1.000 431 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(1), AMY2A(3), AMY2B(3), ASCC3(4), ATP13A2(5), DDX18(1), DDX19A(2), DDX23(3), DDX41(6), DDX50(1), DDX52(2), DHX58(1), ENPP1(2), ENPP3(5), ENTPD7(1), EP400(9), ERCC2(1), ERCC3(1), G6PC(3), G6PC2(1), GAA(4), GANC(1), GCK(2), GPI(3), GUSB(4), GYS1(2), GYS2(2), HK1(2), HK2(4), HK3(1), IFIH1(2), LYZL1(2), MGAM(12), MOV10L1(4), NUDT8(1), PGM3(1), PYGB(3), PYGM(1), RAD54B(2), RAD54L(3), SETX(3), SI(12), SKIV2L2(5), SMARCA2(4), SMARCA5(3), UGP2(2), UGT1A1(2), UGT1A4(1), UGT1A5(1), UGT1A6(1), UGT2A1(2), UGT2A3(3), UGT2B10(3), UGT2B11(3), UGT2B15(5), UGT2B17(3), UGT2B4(1), UGT2B7(1), UXS1(2) 36539286 168 83 167 47 91 6 34 17 20 0 0.294 1.000 1.000 432 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(5), ABCA10(4), ABCA12(16), ABCA13(15), ABCA2(6), ABCA3(3), ABCA4(6), ABCA5(6), ABCA6(5), ABCA7(5), ABCA8(4), ABCA9(4), ABCB1(4), ABCB10(1), ABCB11(4), ABCB4(5), ABCB5(4), ABCB6(1), ABCB7(3), ABCB9(1), ABCC1(1), ABCC10(4), ABCC11(3), ABCC12(1), ABCC2(3), ABCC3(9), ABCC4(5), ABCC5(4), ABCC6(2), ABCC8(4), ABCC9(1), ABCD1(7), ABCD2(1), ABCD3(3), ABCD4(4), ABCG1(3), ABCG2(2), ABCG4(1), ABCG8(2), CFTR(4), TAP1(3), TAP2(2) 34478732 171 82 169 67 71 11 41 20 27 1 0.748 1.000 1.000 433 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(2), BRAF(2), CEBPA(2), CHUK(2), CREB1(2), DAXX(2), ELK1(2), FOS(2), HRAS(1), IKBKB(2), JUN(2), MAP2K1(2), MAP2K3(2), MAP2K7(1), MAP3K1(4), MAP3K10(2), MAP3K12(3), MAP3K13(1), MAP3K2(1), MAP3K3(1), MAP3K4(6), MAP3K5(11), MAP3K6(4), MAP3K8(1), MAP3K9(5), MAP4K1(3), MAP4K2(2), MAP4K3(1), MAP4K4(3), MAP4K5(4), MAPK1(9), MAPK11(2), MAPK13(1), MAPK3(1), MAPK4(1), MAPK6(2), MAPK7(2), MAPK8(1), MAPK9(4), MAPKAPK2(2), MAPKAPK3(1), MAPKAPK5(1), MAX(2), MEF2A(1), MEF2B(1), MEF2C(1), MEF2D(3), MKNK1(1), MKNK2(2), MYC(1), NFKB1(2), NFKBIA(2), PAK1(1), PAK2(1), RAC1(1), RELA(7), RIPK1(2), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA4(1), RPS6KA5(2), RPS6KB1(1), RPS6KB2(1), SP1(3), STAT1(2), TGFB2(1), TGFB3(2), TGFBR1(1), TRAF2(1) 28284207 153 77 147 43 89 6 32 11 15 0 0.379 1.000 1.000 434 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(2), ADCY1(4), ADCY2(3), ADCY3(1), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(4), ADSS(1), AK2(1), AK5(1), ALLC(2), AMPD1(2), AMPD2(2), APRT(1), ATP1B1(1), ATP5D(1), ATP5F1(3), ATP5G3(1), ATP5H(1), ATP5J(2), CANT1(1), DCK(1), DGUOK(2), ENPP1(2), ENPP3(5), GART(1), GDA(3), GMPS(2), GUCY1A2(4), GUCY1A3(3), GUCY1B3(2), GUCY2C(1), GUCY2D(3), GUCY2F(5), GUK1(1), HPRT1(1), IMPDH1(2), IMPDH2(1), NPR1(2), NT5C(2), NT5E(1), PAICS(1), PAPSS1(1), PAPSS2(2), PDE1A(3), PDE4A(3), PDE4B(5), PDE5A(4), PDE6B(1), PDE6C(2), PDE7B(1), PDE8A(1), PDE9A(1), PFAS(2), PKLR(3), POLB(1), POLD1(3), POLD2(1), POLE(7), POLG(3), POLL(1), POLQ(13), POLR1B(3), POLR2A(5), POLR2B(3), POLR2C(1), POLR2F(1), POLR2H(1), POLR2L(1), POLRMT(5), PPAT(1), PRPS2(2), PRUNE(1), RRM1(2) 37262055 177 76 177 78 102 8 38 12 17 0 0.977 1.000 1.000 435 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(5), APH1A(2), CREBBP(15), CTBP1(1), CTBP2(3), DLL1(1), DLL3(1), DTX1(1), DTX3(1), DTX3L(4), DTX4(1), EP300(23), HES1(2), JAG1(3), JAG2(1), LFNG(2), MAML1(3), MAML2(5), MAML3(3), MFNG(1), NCOR2(6), NCSTN(2), NOTCH1(14), NOTCH2(7), NOTCH3(7), NOTCH4(6), NUMB(2), PSEN1(4), PSEN2(1), PSENEN(1), RBPJ(1), RBPJL(2), RFNG(1), SNW1(2) 19653627 134 75 128 42 60 6 36 4 24 4 0.496 1.000 1.000 436 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 BAK1(1), BFAR(3), BTK(4), CAD(8), CASP10(1), CASP3(1), CASP8(9), DAXX(2), DEDD(1), DEDD2(1), DFFA(1), EGFR(7), EPHB2(3), FADD(1), FAF1(4), FAIM2(1), HSPB1(1), IL1A(2), IL8(2), MAP2K7(1), MAP3K1(4), MAP3K5(11), MAPK1(9), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(2), MAPK9(4), MET(2), NFAT5(5), NFKB1(2), NFKB2(1), NFKBIA(2), NFKBIE(2), PTPN13(6), RALBP1(3), RIPK1(2), ROCK1(3), SMPD1(3), TNFRSF6B(1), TP53(12), TPX2(2), TRAF2(1) 21307422 134 75 125 35 76 5 28 6 19 0 0.339 1.000 1.000 437 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(2), BAD(2), CABIN1(5), CALM1(2), CALM3(1), CAMK2B(1), CAMK4(2), CDKN1A(1), CNR1(1), CREBBP(15), EGR3(1), EP300(23), FOS(2), GSK3A(3), HRAS(1), IFNG(1), IL6(1), IL8(2), ITK(1), JUNB(2), KPNA5(3), MAP2K7(1), MAPK8(1), MAPK9(4), MEF2A(1), MEF2B(1), MEF2D(3), NFAT5(5), NFATC1(4), NFATC2(4), NFATC3(5), NFATC4(3), NFKB2(1), NFKBIE(2), NUP214(2), PAK1(1), PIN1(1), PPP3CC(1), PTPRC(10), RELA(7), RPL13A(2), SFN(1), SLA(1), SP1(3), SP3(2), TRAF2(1), TRPV6(2), VAV1(2), VAV2(3), VAV3(3), XPO5(2) 26376895 151 74 146 43 80 8 29 5 25 4 0.313 1.000 1.000 438 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 65 APAF1(3), ATM(11), ATR(6), BAI1(6), BBC3(1), BID(1), CASP3(1), CASP8(9), CASP9(1), CCNB3(4), CCND1(1), CDK2(1), CDKN1A(1), CDKN2A(4), CHEK1(1), CHEK2(1), DDB2(1), EI24(1), FAS(5), GADD45B(1), GTSE1(1), MDM2(1), PERP(1), PPM1D(2), PTEN(17), RCHY1(1), RFWD2(2), RRM2B(1), SERPINB5(1), SESN2(3), SESN3(3), SFN(1), THBS1(2), TNFRSF10B(1), TP53(12), TP53I3(1), TP73(6), TSC2(6) 19000393 122 72 116 37 69 0 18 8 27 0 0.649 1.000 1.000 439 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(1), CD3D(2), DAG1(3), EPHB2(3), FBXW7(20), ITK(1), ITPKA(1), ITPKB(1), LAT(1), LCP2(1), MAPK1(9), NCK1(2), NFAT5(5), NFKB1(2), NFKB2(1), NFKBIA(2), NFKBIE(2), PAK1(1), PAK2(1), PAK3(1), PAK4(2), PAK6(3), PAK7(2), PLCG1(3), PTPRC(10), RASGRP1(1), RASGRP2(5), RASGRP4(5), SOS1(5), SOS2(5), VAV1(2), ZAP70(2) 16222259 105 71 93 23 58 3 26 4 14 0 0.0879 1.000 1.000 440 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 57 ASH1L(7), CARM1(1), CTCFL(2), DOT1L(6), EHMT1(5), EHMT2(3), EZH1(5), EZH2(3), FBXO11(6), HCFC1(5), HSF4(3), JMJD4(1), JMJD6(3), KDM6A(11), NSD1(19), OGT(4), PAXIP1(1), PPP1CB(2), PPP1CC(1), PRDM2(5), PRDM7(1), PRDM9(7), PRMT1(1), PRMT5(1), PRMT6(1), PRMT7(3), SATB1(1), SETD1B(1), SETD2(5), SETD8(2), SETDB1(6), SETDB2(1), SETMAR(5), STK38(2), SUV39H1(1), SUV39H2(2), SUV420H1(2), WHSC1(5), WHSC1L1(3) 35945164 143 70 142 48 81 4 25 12 20 1 0.950 1.000 1.000 441 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 72 B2M(3), CALR(3), CANX(3), CD4(1), CD74(1), CD8A(2), CD8B(1), CIITA(1), CREB1(2), CTSS(3), HLA-A(17), HLA-B(11), HLA-C(5), HLA-DMA(2), HLA-DMB(2), HLA-DPB1(3), HLA-DQA1(3), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(1), HLA-E(2), HLA-F(2), HLA-G(2), HSP90AA1(3), HSP90AB1(1), IFI30(1), IFNA10(1), IFNA4(1), IFNA5(1), IFNA6(1), IFNA8(1), KIR2DL1(1), KIR2DL3(1), KIR3DL1(1), KIR3DL2(1), KIR3DL3(1), KLRC4(1), KLRD1(2), NFYA(3), NFYB(1), NFYC(1), PDIA3(1), RFX5(1), TAP1(3), TAP2(2), TAPBP(5) 11739611 109 69 101 42 48 1 17 7 34 2 0.867 1.000 1.000 442 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 68 ACACB(6), ACSL1(1), ACSL3(2), ACSL4(5), ACSL5(2), ACSL6(1), ADIPOR2(2), AKT1(3), AKT2(1), AKT3(3), CAMKK1(1), CAMKK2(4), CD36(2), CHUK(2), CPT1A(4), CPT1B(3), CPT1C(1), CPT2(1), G6PC(3), G6PC2(1), IKBKB(2), IRS1(2), IRS4(2), JAK1(1), JAK2(6), JAK3(4), LEP(1), LEPR(8), MAPK8(1), MAPK9(4), NFKB1(2), NFKB2(1), NFKBIA(2), NFKBIE(2), PCK2(1), POMC(2), PPARA(1), PPARGC1A(1), PRKAA2(3), PRKAG1(1), PRKAG2(2), PRKCQ(1), RELA(7), RXRA(1), SLC2A1(1), SOCS3(6), STAT3(2), STK11(8), TNFRSF1A(4), TNFRSF1B(2), TRAF2(1), TYK2(9) 23523251 139 69 138 33 77 9 27 8 16 2 0.0396 1.000 1.000 443 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(3), BAD(2), BAK1(1), BCL2L11(3), BID(1), BIRC2(2), BIRC3(1), CASP1(1), CASP10(1), CASP2(2), CASP3(1), CASP6(2), CASP8(9), CASP9(1), CHUK(2), DFFA(1), DFFB(1), FADD(1), FAS(5), FASLG(1), GZMB(1), HELLS(1), IKBKB(2), IRF1(3), IRF2(1), IRF5(2), IRF6(2), IRF7(3), JUN(2), MAP3K1(4), MDM2(1), MYC(1), NFKB1(2), NFKBIA(2), NFKBIE(2), PLEKHG5(4), PRF1(1), RELA(7), RIPK1(2), TNFRSF10B(1), TNFRSF1A(4), TNFRSF1B(2), TNFRSF21(2), TNFSF10(2), TP53(12), TP73(6), TRAF1(1), TRAF2(1), TRAF3(3) 16390986 118 67 114 33 62 6 20 8 22 0 0.463 1.000 1.000 444 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 91 CD2BP2(1), CDC40(1), CLK2(3), CLK3(2), CLK4(2), COL2A1(7), CPSF1(10), CPSF2(2), CPSF3(1), CPSF4(3), CSTF1(1), CSTF2(3), CSTF2T(2), CSTF3(4), DDIT3(1), DDX1(1), DDX20(3), DHX15(1), DHX16(1), DHX38(4), DHX8(4), DHX9(5), DICER1(3), DNAJC8(2), FUS(1), GIPC1(1), METTL3(1), NCBP1(2), NONO(2), NXF1(5), PABPN1(1), PAPOLA(1), POLR2A(5), PPM1G(2), PRPF18(2), PRPF3(2), PRPF4(3), PRPF4B(2), PRPF8(5), PTBP1(3), RBM17(2), RBM5(4), RNGTT(3), RNMT(2), SF3A3(1), SF3B1(1), SF3B2(2), SF3B4(2), SNRPA1(2), SNRPB(1), SNRPD1(1), SNRPD2(1), SNRPD3(1), SNURF(1), SPOP(1), SRPK2(5), SUPT5H(2), TXNL4A(2), U2AF1(2), U2AF2(1), XRN2(3) 30589623 145 67 144 46 85 6 22 9 23 0 0.871 1.000 1.000 445 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 107 A4GNT(1), ALG1(2), ALG13(6), ALG6(3), ALG8(3), ALG9(1), B4GALT3(1), B4GALT4(1), B4GALT5(1), B4GALT7(1), C1GALT1C1(4), CHPF(1), CHST11(2), CHST12(2), CHST14(1), CHST3(2), CHST4(2), CHSY1(1), DPAGT1(1), EXTL1(2), EXTL3(1), FUT11(1), FUT8(3), GALNT1(1), GALNT11(2), GALNT13(1), GALNT14(3), GALNT3(1), GALNT4(2), GALNT5(2), GALNT6(1), GALNT7(2), GALNT9(4), GALNTL5(1), GANAB(4), GCNT3(1), GCNT4(1), HS2ST1(1), HS3ST2(1), HS3ST3A1(2), HS3ST3B1(1), HS3ST5(1), HS6ST2(5), MAN1A1(1), MAN1A2(1), MAN1B1(3), MAN1C1(3), MAN2A1(3), MGAT2(1), MGAT3(3), MGAT5(2), MGAT5B(1), NDST2(4), NDST3(5), NDST4(4), OGT(4), RPN1(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(1), ST6GAL1(2), ST6GALNAC1(2), UST(1), WBSCR17(5), XYLT2(1) 31238004 132 66 131 47 70 6 31 10 15 0 0.583 1.000 1.000 446 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 51 ACTG1(5), APAF1(3), BAG4(1), BID(1), BIRC2(2), BIRC3(1), CASP2(2), CASP3(1), CASP6(2), CASP8(9), CASP9(1), CHUK(2), DAXX(2), DFFA(1), DFFB(1), FADD(1), GSN(2), LMNB1(1), MAP2K7(1), MAP3K1(4), MAP3K5(11), MAPK8(1), MDM2(1), NFKB1(2), NFKBIA(2), NUMA1(3), PAK2(1), PRKCD(1), PRKDC(11), PSEN1(4), PSEN2(1), PTK2(2), RASA1(4), RB1(9), RELA(7), RIPK1(2), SPTAN1(11), TNFRSF1A(4), TNFRSF1B(2), TRAF1(1), TRAF2(1) 20271656 124 64 121 35 56 8 20 11 28 1 0.589 1.000 1.000 447 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 63 ATM(11), CCNA1(2), CCND1(1), CDC25A(2), CDK2(1), CDKN1A(1), CDKN2A(4), CREB3(1), CREB3L1(1), CREB3L3(3), CREB3L4(2), E2F2(1), E2F3(3), E2F4(1), E2F5(1), E2F6(1), GBA2(1), MCM2(1), MCM5(2), MCM6(1), MCM7(3), MDM2(1), MYC(1), MYT1(4), NACA(3), PCNA(1), POLA2(1), POLE(7), PRIM1(1), RB1(9), RBL1(3), RPA1(4), RPA2(1), TFDP1(2), TNXB(7), TP53(12) 21501036 101 62 99 24 48 7 19 9 17 1 0.244 1.000 1.000 448 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 85 AK3(1), CAD(8), CANT1(1), CTPS2(2), DCK(1), DCTD(1), DHODH(1), DPYD(3), DPYS(1), ENTPD3(2), ENTPD4(1), NME6(1), NME7(1), NT5C(2), NT5C1A(2), NT5C1B(2), NT5C2(3), NT5E(1), PNPT1(1), POLA1(5), POLA2(1), POLD1(3), POLD2(1), POLD3(1), POLE(7), POLR1A(7), POLR1B(3), POLR1C(3), POLR2A(5), POLR2B(3), POLR2C(1), POLR2F(1), POLR2H(1), POLR2L(1), POLR3A(1), POLR3B(3), POLR3G(2), PRIM1(1), RFC5(2), RRM1(2), RRM2B(1), TXNRD1(2), UCK1(1), UMPS(1), UPP2(2) 23922516 96 62 96 39 49 4 23 9 11 0 0.908 1.000 1.000 449 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 66 A2M(2), C1QC(1), C1R(1), C1S(1), C2(1), C3(6), C4BPA(2), C5(3), C5AR1(2), C6(5), C7(3), C8B(2), C8G(3), C9(1), CD55(1), CFB(1), CFH(6), CFI(2), CPB2(3), CR1(4), CR2(3), F10(1), F11(1), F12(1), F13A1(2), F13B(2), F2R(1), F5(7), F7(2), F8(9), F9(3), FGA(6), FGG(1), KLKB1(2), MASP1(1), MASP2(2), PLAT(3), PLAU(1), PLG(1), PROS1(2), SERPINC1(1), SERPIND1(2), SERPINF2(1), SERPING1(2), TFPI(1), THBD(2), VWF(6) 26070293 116 60 115 36 61 8 24 11 11 1 0.627 1.000 1.000 450 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 84 ANPEP(1), CD14(3), CD19(1), CD1A(2), CD1B(1), CD1E(2), CD22(3), CD34(2), CD36(2), CD3D(2), CD4(1), CD44(2), CD5(1), CD55(1), CD8A(2), CD8B(1), CR1(4), CR2(3), CSF1R(2), CSF3R(3), DNTT(1), EPOR(1), FCGR1A(1), FLT3(3), GP5(1), GP9(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(1), IL11(1), IL11RA(2), IL1A(2), IL1R1(2), IL1R2(2), IL3RA(2), IL4R(5), IL5(1), IL5RA(2), IL6(1), IL6R(3), IL9R(3), ITGA1(3), ITGA2(3), ITGA2B(1), ITGA3(1), ITGA4(6), ITGA5(2), ITGAM(4), ITGB3(3), KIT(3), KITLG(1), MME(2), THPO(1), TPO(6) 23771930 112 60 112 41 56 8 28 6 14 0 0.762 1.000 1.000 451 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(3), ALG6(3), CCKBR(1), CCR2(1), CCR3(1), CELSR1(7), CELSR2(7), CELSR3(5), CHRM2(3), CHRM3(3), CIDEB(2), CXCR3(1), EDNRA(1), EMR2(3), EMR3(1), F2R(1), FSHR(2), GPR116(4), GPR132(1), GPR133(2), GPR143(1), GPR18(1), GPR56(2), GPR61(1), GRM1(3), GRPR(4), HRH4(2), LGR6(2), LPHN2(4), LPHN3(10), NTSR1(1), OR2M4(1), P2RY13(3), PTGFR(1), SMO(1), TAAR5(2), VN1R1(4) 19155349 95 55 95 30 41 7 26 10 11 0 0.114 1.000 1.000 452 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(4), ADCY6(4), ADCY8(4), CACNA1A(4), CACNA1B(9), GNAS(6), GNAT3(2), GNB1(1), GNB3(1), GRM4(1), ITPR3(2), KCNB1(1), PDE1A(3), PLCB2(2), PRKACA(2), SCNN1A(3), SCNN1G(3), TAS1R1(3), TAS1R2(4), TAS1R3(3), TAS2R1(1), TAS2R13(2), TAS2R16(2), TAS2R4(1), TAS2R41(2), TAS2R42(1), TAS2R43(2), TAS2R60(2), TAS2R7(2), TRPM5(2) 16761981 79 54 78 36 38 5 27 4 5 0 0.654 1.000 1.000 453 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(3), AKT2(1), AKT3(3), ASAH1(2), BRAF(2), DAG1(3), EGFR(7), EPHB2(3), ITPKA(1), ITPKB(1), ITPR1(8), ITPR2(5), ITPR3(2), KCNJ5(1), KCNJ9(1), MAPK1(9), PIK3CB(2), PITX2(2), PLCB1(10), PLCB2(2), PLCB3(2), PLCB4(1), RGS20(1), SOS1(5), SOS2(5), STAT3(2) 17033502 84 54 77 29 56 4 13 4 7 0 0.603 1.000 1.000 454 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASS(2), ACAT1(2), ACAT2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), BBOX1(4), DOT1L(6), EHHADH(1), EHMT1(5), EHMT2(3), GCDH(2), HADH(1), HSD17B10(1), HSD17B4(10), HSD3B7(1), NSD1(19), OGDH(4), OGDHL(3), PLOD1(2), PLOD3(1), RDH13(1), SETDB1(6), SHMT1(2), SHMT2(1), SUV39H1(1), SUV39H2(2), TMLHE(1) 16381948 91 53 90 30 55 3 15 8 10 0 0.594 1.000 1.000 455 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 66 ACADM(4), ACOX1(1), ACOX2(3), ACOX3(2), ACSL1(1), ACSL3(2), ACSL4(5), ACSL5(2), ACSL6(1), AQP7(1), CD36(2), CPT1A(4), CPT1B(3), CPT1C(1), CPT2(1), CYP27A1(3), CYP4A22(2), CYP7A1(2), CYP8B1(1), DBI(1), EHHADH(1), FABP1(1), FABP3(1), FABP4(1), GK(2), GK2(1), LPL(2), ME1(1), MMP1(3), NR1H3(3), PCK2(1), PDPK1(2), PPARA(1), PPARD(2), PPARG(1), RXRA(1), SCP2(1), SLC27A1(3), SLC27A2(4), SLC27A4(2), SLC27A5(7), SLC27A6(1), SORBS1(5), UBC(2) 18707384 91 53 91 32 46 8 19 4 14 0 0.531 1.000 1.000 456 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(3), ATF2(2), CDC42(1), DUSP10(1), DUSP8(1), GAB1(2), GCK(2), IL1R1(2), JUN(2), MAP2K7(1), MAP3K1(4), MAP3K10(2), MAP3K12(3), MAP3K13(1), MAP3K2(1), MAP3K3(1), MAP3K4(6), MAP3K5(11), MAP3K9(5), MAPK7(2), MAPK8(1), MAPK9(4), MYEF2(1), NFATC3(5), NR2C2(1), PAPPA(1), TP53(12), TRAF6(1), ZAK(5) 14529693 84 53 81 25 48 3 17 6 10 0 0.676 1.000 1.000 457 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1B(2), ADH4(1), ADH6(1), ADH7(1), ADHFE1(1), AGPAT2(1), AGPAT4(1), AGPAT6(1), AKR1A1(1), AKR1B1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), CEL(3), DGAT1(2), DGAT2(1), DGKA(3), DGKB(1), DGKE(1), DGKG(3), DGKH(2), DGKI(4), DGKQ(1), DGKZ(5), GK(2), GK2(1), GLA(1), GLB1(4), GPAM(2), LCT(3), LIPA(1), LIPC(2), LIPF(1), LIPG(2), LPL(2), PNLIP(3), PNLIPRP1(3), PNLIPRP2(2), PNPLA3(1), PPAP2B(4) 17205484 80 51 80 23 35 4 21 4 16 0 0.236 1.000 1.000 458 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 70 ADH1B(2), ADH4(1), ADH6(1), ADH7(1), ADHFE1(1), AKR1C1(2), AKR1C2(1), AKR1C4(2), ALDH1A3(2), ALDH3A1(1), CYP1A1(1), CYP1A2(1), CYP2C18(3), CYP2C19(1), CYP2C9(3), CYP2E1(1), CYP2F1(1), CYP3A43(2), CYP3A5(2), CYP3A7(1), DHDH(1), GSTA2(2), GSTA3(2), GSTA4(1), GSTA5(1), GSTM2(1), GSTM4(1), GSTT1(2), GSTT2(1), GSTZ1(1), MGST3(1), UGT1A1(2), UGT1A4(1), UGT1A5(1), UGT1A6(1), UGT2A1(2), UGT2A3(3), UGT2B10(3), UGT2B11(3), UGT2B15(5), UGT2B17(3), UGT2B4(1), UGT2B7(1) 17027873 70 51 70 26 41 2 14 8 5 0 0.604 1.000 1.000 459 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP10(1), CASP3(1), CASP6(2), CASP8(9), DAXX(2), DFFA(1), DFFB(1), FADD(1), FAF1(4), JUN(2), LMNB1(1), MAP3K1(4), MAPK8(1), PAK1(1), PAK2(1), PRKDC(11), PTPN13(6), RB1(9), SPTAN1(11) 12366968 69 50 66 27 29 3 10 5 21 1 0.978 1.000 1.000 460 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 34 ACTG1(5), ACTG2(1), ACTR2(1), AKT1(3), CDC42(1), FLNA(10), FLNC(11), FSCN1(2), GDI1(2), LIMK1(4), MYH2(9), MYLK(2), PAK1(1), PAK2(1), PAK3(1), PAK4(2), PAK6(3), PAK7(2), ROCK1(3), ROCK2(4), RPS4X(2), VASP(1), WASF1(3), WASL(4) 13820615 78 50 77 31 46 4 17 2 9 0 0.805 1.000 1.000 461 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 AK3(1), CAD(8), CANT1(1), CTPS2(2), DCK(1), DCTD(1), DHODH(1), DPYD(3), DPYS(1), NT5C(2), NT5E(1), POLB(1), POLD1(3), POLD2(1), POLE(7), POLG(3), POLL(1), POLQ(13), POLR1B(3), POLR2A(5), POLR2B(3), POLR2C(1), POLR2F(1), POLR2H(1), POLR2L(1), POLRMT(5), RRM1(2), TXNRD1(2), UCK1(1), UMPS(1), UNG(2) 16642141 79 49 79 26 41 2 18 6 12 0 0.555 1.000 1.000 462 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 92 ANK2(14), B3GALT4(2), CDR1(1), DGKI(4), IL6ST(2), PIGK(2), RPL10(1), RPL11(1), RPL13A(2), RPL18(1), RPL27(1), RPL28(3), RPL29(2), RPL3(2), RPL31(1), RPL35(1), RPL36(1), RPL4(3), RPL6(2), RPL7A(2), RPL8(1), RPL9(1), RPS10(1), RPS13(2), RPS19(1), RPS2(1), RPS21(1), RPS23(1), RPS24(1), RPS25(1), RPS3A(1), RPS4X(2), RPS5(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA6(6), RPS6KB1(1), RPS6KB2(1), RPS7(1), RPS9(1), SLC36A2(3), TBC1D10C(2), UBA52(1), UBC(2) 15330004 86 49 86 31 57 3 12 1 13 0 0.657 1.000 1.000 463 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(3), CDC42(1), CREB1(2), CREB3(1), CREB5(5), DUSP1(1), DUSP10(1), EEF2K(2), ELK1(2), HSPB1(1), IL1R1(2), MAP2K3(2), MAP3K10(2), MAP3K4(6), MAP3K5(11), MAPK1(9), MAPK11(2), MAPK13(1), MAPKAPK2(2), MAPKAPK5(1), MKNK1(1), MKNK2(2), MYEF2(1), NFKB1(2), NR2C2(1), TRAF6(1) 9755810 65 49 58 19 39 1 16 3 6 0 0.512 1.000 1.000 464 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM1(2), CALM3(1), CAMK1(2), ELK1(2), FPR1(1), GNA15(4), GNB1(1), GNGT1(1), HRAS(1), MAP2K1(2), MAP2K3(2), MAP3K1(4), MAPK1(9), MAPK3(1), NCF2(2), NFATC1(4), NFATC2(4), NFATC3(5), NFATC4(3), NFKB1(2), NFKBIA(2), PAK1(1), PIK3C2G(5), PLCB1(10), PPP3CA(1), PPP3CC(1), RAC1(1), RELA(7), SYT1(2) 11170403 83 48 77 22 55 3 15 6 4 0 0.314 1.000 1.000 465 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(3), ACSS2(2), ADH1B(2), ADH4(1), ADH6(1), ADH7(1), ADHFE1(1), AKR1A1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), ALDOA(3), ALDOB(1), ALDOC(1), DLAT(2), ENO1(3), ENO3(4), G6PC(3), G6PC2(1), GALM(1), GAPDH(1), GAPDHS(2), GCK(2), GPI(3), HK1(2), HK2(4), HK3(1), LDHAL6A(1), LDHAL6B(1), LDHC(3), PDHA1(1), PDHA2(4), PDHB(2), PGAM1(1), PGK1(1), PGK2(1), PGM3(1), PKLR(3) 16998923 74 48 73 22 43 3 13 6 9 0 0.216 1.000 1.000 466 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 66 ADAM10(2), ADAM17(5), ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1E2(1), ATP6V1F(1), CASP3(1), CDC42(1), CHUK(2), EGFR(7), F11R(2), IKBKB(2), IL8(2), JUN(2), MAPK11(2), MAPK13(1), MAPK8(1), MAPK9(4), MET(2), NFKB1(2), NFKB2(1), NFKBIA(2), NOD1(1), PAK1(1), PLCG1(3), PLCG2(4), PTPRZ1(4), RAC1(1), RELA(7), TJP1(7) 20742851 85 48 85 27 46 3 19 5 12 0 0.524 1.000 1.000 467 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 35 AKT1(3), AKT2(1), AKT3(3), ARHGEF11(8), CDC42(1), DLG4(2), GNA13(3), LPA(2), MAP3K1(4), MAP3K5(11), MAPK8(1), NFKB1(2), NFKB2(1), NFKBIA(2), NFKBIE(2), PDK1(3), PHKA2(7), PIK3CB(2), PLD1(3), PTK2(2), RDX(2), ROCK1(3), ROCK2(4), SERPINA4(2), TBXA2R(1) 14316726 75 48 73 18 42 2 17 7 7 0 0.276 1.000 1.000 468 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(2), ANAPC2(4), ANAPC5(1), ANAPC7(1), BTRC(1), CDC16(1), CDC20(2), CDC27(3), CUL1(4), CUL2(2), CUL3(1), FBXW11(1), FBXW7(20), FZR1(2), ITCH(2), RBX1(1), SMURF2(2), UBA1(2), UBE2D1(1), UBE2E1(2), WWP2(4) 11947840 59 47 53 17 32 0 12 2 12 1 0.684 1.000 1.000 469 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(8), ACTB(2), ACTG1(5), ARHGEF2(3), CD14(3), CDC42(1), CDH1(2), CTNNB1(5), CTTN(1), EZR(6), FYN(3), HCLS1(1), ITGB1(2), KRT18(2), LY96(2), NCK1(2), NCL(3), OCLN(1), PRKCA(3), RHOA(2), ROCK1(3), ROCK2(4), TLR4(2), TLR5(2), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3C(2), TUBA3D(1), TUBA8(2), TUBB(1), TUBB8(1), WASL(4), YWHAQ(2), YWHAZ(3) 15075089 88 47 87 33 53 2 18 7 8 0 0.866 1.000 1.000 470 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(8), ACTB(2), ACTG1(5), ARHGEF2(3), CD14(3), CDC42(1), CDH1(2), CTNNB1(5), CTTN(1), EZR(6), FYN(3), HCLS1(1), ITGB1(2), KRT18(2), LY96(2), NCK1(2), NCL(3), OCLN(1), PRKCA(3), RHOA(2), ROCK1(3), ROCK2(4), TLR4(2), TLR5(2), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3C(2), TUBA3D(1), TUBA8(2), TUBB(1), TUBB8(1), WASL(4), YWHAQ(2), YWHAZ(3) 15075089 88 47 87 33 53 2 18 7 8 0 0.866 1.000 1.000 471 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(3), BAK1(1), BID(1), BIRC2(2), BIRC3(1), CASP2(2), CASP3(1), CASP6(2), CASP8(9), CASP9(1), FADD(1), FAS(5), FASLG(1), GZMB(1), JUN(2), MAP3K1(4), MCL1(1), MDM2(1), MYC(1), NFKB1(2), NFKBIA(2), PARP1(2), PRF1(1), RELA(7), RIPK1(2), TNFRSF1A(4), TNFRSF1B(2), TNFSF10(2), TP53(12), TRAF1(1), TRAF2(1) 10665316 78 46 75 22 41 4 13 6 14 0 0.479 1.000 1.000 472 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(2), CALM1(2), CALM3(1), CAMK2A(3), CAMK2B(1), CAMK2D(2), FYN(3), GNA11(2), GNAI1(1), GNB1(1), GNGT1(1), HRAS(1), JAK2(6), MAP2K1(2), MAPK1(9), MAPK3(1), MAPK8(1), MAPT(2), MYLK(2), PLCG1(3), PRKCA(3), PTK2B(3), SOS1(5), STAT1(2), STAT3(2), STAT5A(2), SYT1(2) 12215737 65 46 59 18 38 3 17 2 4 1 0.263 1.000 1.000 473 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 43 CEBPA(2), CHUK(2), DAXX(2), EGF(1), EGFR(7), ETS2(1), FOS(2), HOXA7(1), HRAS(1), IKBKB(2), JUN(2), MAP2K1(2), MAP2K3(2), MAP2K7(1), MAP3K1(4), MAP3K5(11), MAPK1(9), MAPK13(1), MAPK3(1), MAPK8(1), NFKB1(2), NFKBIA(2), PRKCA(3), PRKCD(1), PRKCE(1), PRKCG(1), PRKCH(1), PRKCQ(1), RELA(7), RIPK1(2), SP1(3), TNFRSF1A(4), TNFRSF1B(2), TRAF2(1) 14173987 86 46 80 25 58 3 15 4 6 0 0.339 1.000 1.000 474 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(1), ARHGAP4(6), ARHGAP5(4), ARHGAP6(8), ARHGEF1(1), ARHGEF11(8), ARHGEF5(5), ARPC1A(2), ARPC2(3), DIAPH1(1), GSN(2), LIMK1(4), MYLK(2), OPHN1(2), PIP5K1A(1), PIP5K1B(1), PPP1R12B(3), ROCK1(3), TLN1(3), VCL(3) 13586710 63 46 63 20 38 0 12 1 12 0 0.604 1.000 1.000 475 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 27 BAG4(1), CASP2(2), CASP3(1), CASP8(9), DFFA(1), DFFB(1), FADD(1), JUN(2), LMNB1(1), MADD(7), MAP3K1(4), MAPK8(1), PAK1(1), PAK2(1), PRKDC(11), RB1(9), RIPK1(2), SPTAN1(11), TNFRSF1A(4), TRAF2(1) 11363625 71 46 68 25 31 4 9 5 21 1 0.891 1.000 1.000 476 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(8), ATM(11), BRCA1(5), CDKN1A(1), CHEK1(1), CHEK2(1), JUN(2), MAPK8(1), MDM2(1), MRE11A(1), NFKB1(2), NFKBIA(2), RAD51(1), RBBP8(4), RELA(7), TP53(12), TP73(6) 8524661 66 45 64 18 39 1 12 3 10 1 0.816 1.000 1.000 477 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 24 ABL1(8), ATM(11), ATR(6), CCNA1(2), CCND1(1), CDC25A(2), CDK2(1), CDKN1A(1), CDKN2A(4), RB1(9), TFDP1(2), TGFB2(1), TGFB3(2), TP53(12) 8610907 62 45 60 15 32 3 10 5 11 1 0.465 1.000 1.000 478 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(3), APC(7), ASAH1(2), DAG1(3), DLG4(2), EPHB2(3), GNAI1(1), GNAQ(2), ITPR1(8), ITPR2(5), ITPR3(2), KCNJ5(1), KCNJ9(1), MAPK1(9), PITX2(2), PTX3(1), RAC1(1), RYR1(10) 13437141 63 45 55 19 40 2 12 3 6 0 0.329 1.000 1.000 479 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(7), CCND1(1), CTNNB1(5), FBXW2(1), FZD1(1), FZD10(2), FZD2(2), FZD3(1), FZD5(2), FZD6(2), FZD7(1), FZD8(1), JUN(2), LDLR(1), MAPK9(4), MYC(1), PAFAH1B1(2), PLAU(1), PPP2R5C(2), PPP2R5E(2), PRKCA(3), PRKCD(1), PRKCE(1), PRKCG(1), PRKCH(1), PRKCI(6), PRKCQ(1), PRKCZ(1), PRKD1(4), RAC1(1), RHOA(2), SFRP4(1), WNT1(1), WNT10A(1), WNT11(1), WNT16(1), WNT2B(1), WNT5B(2), WNT7B(4) 16916110 75 45 73 26 44 1 15 10 5 0 0.605 1.000 1.000 480 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(1), AKT1(3), CALM1(2), CALM3(1), CHRM1(1), CHRNA1(2), FLT1(7), FLT4(7), KDR(2), NOS3(6), PDE2A(2), PDE3A(5), PRKAR2A(1), PRKG2(3), RYR2(26), SLC7A1(2), SYT1(2) 12248513 73 44 72 25 35 4 21 4 9 0 0.568 1.000 1.000 481 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(1), ATP8A1(3), AVPR1A(1), AVPR1B(2), AVPR2(2), BRS3(3), CCKAR(1), CCKBR(1), CCR1(3), CCR2(1), CCR3(1), CCR4(2), CCR6(1), CCR7(1), CCR8(2), CX3CR1(2), CXCR3(1), CXCR4(3), CXCR6(1), EDNRA(1), EDNRB(2), FPR1(1), FSHR(2), GALR2(1), GALT(2), GHSR(2), GRPR(4), LHCGR(1), MC1R(1), MC2R(1), MC3R(1), MC5R(2), NPY1R(2), NPY2R(2), NPY5R(4), NTSR1(1), OPRL1(1), OPRM1(3), OXTR(3), TACR1(1), TACR2(1) 14820727 71 44 71 28 35 7 19 5 5 0 0.212 1.000 1.000 482 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(2), AGPAT2(1), AGPAT4(1), AGPAT6(1), CHAT(2), CHKA(2), CHKB(3), CHPT1(1), DGKA(3), DGKB(1), DGKE(1), DGKG(3), DGKH(2), DGKI(4), DGKQ(1), DGKZ(5), ESCO1(1), ESCO2(1), ETNK1(1), ETNK2(1), GPAM(2), GPD1L(1), LCAT(3), NAT6(1), PCYT1A(2), PCYT1B(1), PEMT(1), PHOSPHO1(1), PLA2G12A(1), PLA2G12B(3), PLA2G2D(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLD1(3), PNPLA3(1), PPAP2B(4), PTDSS1(1), PTDSS2(2), SH3GLB1(2) 19157342 73 43 73 24 44 1 17 4 7 0 0.499 1.000 1.000 483 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 46 APAF1(3), BAD(2), CASP1(1), CASP10(1), CASP2(2), CASP3(1), CASP6(2), CASP8(9), CASP9(1), CD40(1), CD40LG(3), DAXX(2), DFFA(1), DFFB(1), FADD(1), FAS(5), FASLG(1), IKBKE(1), MCL1(1), NFKB1(2), NFKBIA(2), NGFR(1), NR3C1(4), PTPN13(6), RIPK1(2), TFG(1), TNFRSF1A(4), TNFRSF1B(2), TRAF1(1), TRAF2(1), TRAF3(3), TRAF6(1) 12507462 69 42 66 21 36 3 8 4 18 0 0.697 1.000 1.000 484 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 55 ADH1B(2), ADH4(1), ADH6(1), ADH7(1), ADHFE1(1), ALDH1A3(2), ALDH3A1(1), AOC2(1), AOC3(3), AOX1(3), CARM1(1), DBH(1), DCT(2), DDC(2), ESCO1(1), ESCO2(1), FAH(3), GOT2(1), GSTZ1(1), HEMK1(1), HGD(2), HPD(2), LCMT1(4), LCMT2(1), MAOA(1), MAOB(3), METTL2B(1), NAT6(1), PNPLA3(1), PRMT2(1), PRMT5(1), PRMT6(1), PRMT7(3), SH3GLB1(2), TAT(3), TH(2), TPO(6), TYR(2) 17143077 67 42 67 21 40 2 15 4 6 0 0.475 1.000 1.000 485 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP4(2), BMP5(1), BMP6(1), BMP8A(1), BTRC(1), CSNK1D(2), CSNK1G1(1), CSNK1G3(2), DHH(2), FBXW11(1), GLI1(2), GLI2(6), GLI3(4), IHH(1), LRP2(18), PRKACA(2), PTCH1(2), PTCH2(3), RAB23(1), SMO(1), STK36(1), SUFU(2), WNT1(1), WNT10A(1), WNT11(1), WNT16(1), WNT2B(1), WNT5B(2), WNT7B(4), WNT8A(1), WNT8B(3), ZIC2(2) 16990134 74 42 74 24 32 5 26 7 4 0 0.496 1.000 1.000 486 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(1), ATP5D(1), ATP5F1(3), ATP5G3(1), ATP5H(1), ATP5J(2), ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1E2(1), ATP6V1F(1), COX10(1), COX4I1(1), COX4I2(2), COX5A(2), COX6A1(1), COX7A2(1), COX8A(1), NDUFA1(1), NDUFA11(1), NDUFA5(1), NDUFA8(1), NDUFA9(1), NDUFB10(1), NDUFB11(3), NDUFB7(2), NDUFS1(1), NDUFS2(1), NDUFS3(1), NDUFS4(1), NDUFS6(1), NDUFV1(3), SDHA(4), SDHB(1), SDHD(1), UQCRB(2), UQCRC1(1), UQCRC2(3), UQCRFS1(1), UQCRQ(1) 16501760 67 41 67 25 30 3 16 3 15 0 0.694 1.000 1.000 487 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ADC(1), ALDH4A1(3), ALDH5A1(1), CAD(8), CPS1(1), EPRS(7), GAD1(4), GCLM(1), GFPT1(3), GFPT2(5), GLS2(2), GLUD1(2), GLUD2(1), GLUL(1), GMPS(2), GNPNAT1(1), GOT2(1), GPT2(2), GSR(1), NADSYN1(5), PPAT(1), QARS(2) 11554144 55 41 55 20 31 0 14 4 6 0 0.670 1.000 1.000 488 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 ACAT1(2), ACAT2(1), ACMSD(1), AFMID(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), AOC2(1), AOC3(3), AOX1(3), ASMT(1), CARM1(1), CAT(2), CYP1A1(1), CYP1A2(1), DDC(2), EHHADH(1), GCDH(2), HAAO(2), HADH(1), HEMK1(1), HSD17B10(1), HSD17B4(10), KMO(1), LCMT1(4), LCMT2(1), MAOA(1), MAOB(3), METTL2B(1), NFX1(2), OGDH(4), OGDHL(3), PRMT2(1), PRMT5(1), PRMT6(1), PRMT7(3), TPH1(2), WARS(1), WARS2(1) 17592001 77 41 77 22 46 4 14 7 6 0 0.287 1.000 1.000 489 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(3), ALPL(1), ALPP(2), ALPPL2(1), ASCC3(4), ATP13A2(5), DDX18(1), DDX19A(2), DDX23(3), DDX41(6), DDX50(1), DDX52(2), DHX58(1), ENTPD7(1), EP400(9), ERCC2(1), ERCC3(1), GGH(2), IFIH1(2), MOV10L1(4), NUDT8(1), RAD54B(2), RAD54L(3), SETX(3), SKIV2L2(5), SMARCA2(4), SMARCA5(3) 18395912 73 41 72 26 45 1 14 2 11 0 0.722 1.000 1.000 490 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(3), CARS(1), CARS2(1), DARS2(2), EPRS(7), FARS2(1), GARS(1), HARS2(1), IARS2(3), LARS(3), LARS2(1), MARS(2), MARS2(2), NARS2(3), QARS(2), RARS2(5), SARS(1), SARS2(3), TARS(2), TARS2(3), VARS(2), VARS2(1), WARS(1), WARS2(1), YARS(2), YARS2(1) 15093905 55 41 54 17 39 1 8 3 4 0 0.526 1.000 1.000 491 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 27 ADRBK1(2), AKT1(3), AKT2(1), AKT3(3), DAG1(3), GNAQ(2), ITPKA(1), ITPKB(1), ITPR1(8), ITPR2(5), ITPR3(2), NFKB1(2), NFKB2(1), NFKBIA(2), NFKBIE(2), PDK1(3), PHKA2(7), PIK3CB(2), PITX2(2), PLD1(3), VN1R1(4) 13254740 59 41 58 21 35 3 12 5 4 0 0.626 1.000 1.000 492 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 36 ANKHD1(10), EEF1A2(1), EEF1B2(1), EEF1G(1), EEF2(2), EEF2K(2), EIF1AX(1), EIF2AK1(4), EIF2AK2(3), EIF2AK3(2), EIF2B2(2), EIF2B4(2), EIF2B5(1), EIF2S1(3), EIF2S2(2), EIF4A1(3), EIF4A2(3), EIF4G1(5), EIF4G3(4), EIF5(1), EIF5A(1), EIF5B(3), ETF1(3), GSPT2(4), PABPC3(4), PAIP1(1), SLC35A4(1) 12969557 70 41 70 21 41 3 10 6 10 0 0.701 1.000 1.000 493 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDC7(2), CDK2(1), CDT1(2), DIAPH2(4), GMNN(2), MCM10(4), MCM2(1), MCM5(2), MCM6(1), MCM7(3), NACA(3), PCNA(1), POLA2(1), POLD1(3), POLD2(1), POLD3(1), POLE(7), PRIM1(1), RFC1(2), RFC2(1), RFC3(1), RFC5(2), RPA1(4), RPA2(1), RPA4(3), UBA52(1), UBC(2) 14766741 58 40 58 18 36 3 8 2 9 0 0.574 1.000 1.000 494 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 B3GALNT1(1), B3GALT1(2), B3GALT4(2), B3GALT5(2), B3GNT3(1), B3GNT5(3), B4GALT3(1), B4GALT4(1), B4GALT6(1), FUT1(2), FUT2(3), FUT6(1), FUT9(3), GCNT2(3), PIGA(2), PIGG(2), PIGH(1), PIGK(2), PIGM(1), PIGN(1), PIGO(2), PIGQ(2), PIGU(2), PIGX(1), ST3GAL1(2), ST3GAL2(1), ST3GAL3(1), ST3GAL5(2), ST3GAL6(1), ST6GALNAC3(3), ST6GALNAC5(1), ST6GALNAC6(3), ST8SIA1(2), ST8SIA5(1), UGCG(2) 14221040 61 40 61 21 28 6 17 3 7 0 0.371 1.000 1.000 495 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(1), ACTN1(1), ACTN2(2), BCR(2), CAPN1(5), CAPNS1(1), FYN(3), HRAS(1), ITGA1(3), ITGB1(2), JUN(2), MAP2K1(2), MAPK1(9), MAPK3(1), MAPK8(1), PPP1R12B(3), PTK2(2), PXN(2), RAP1A(1), ROCK1(3), SOS1(5), TLN1(3), VCL(3), ZYX(1) 13806563 59 40 53 23 30 3 13 3 10 0 0.855 1.000 1.000 496 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(2), BCR(2), BLNK(2), ELK1(2), FOS(2), HRAS(1), JUN(2), MAP2K1(2), MAP3K1(4), MAPK1(9), MAPK3(1), MAPK8IP3(2), PAPPA(1), RAC1(1), RPS6KA1(1), RPS6KA3(2), SOS1(5), SYK(1), VAV1(2), VAV2(3), VAV3(3) 9348405 50 40 44 17 29 2 11 3 5 0 0.678 1.000 1.000 497 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(2), AGPAT2(1), AGPAT4(1), AGPS(2), CHAT(2), CHKA(2), CHKB(3), CLC(1), CPT1B(3), DGKA(3), DGKB(1), DGKE(1), DGKG(3), DGKH(2), DGKQ(1), DGKZ(5), ETNK1(1), LCAT(3), PAFAH1B1(2), PCYT1A(2), PCYT1B(1), PEMT(1), PLA2G4A(3), PLA2G6(2), PLCB2(2), PLCG1(3), PLCG2(4), PPAP2B(4) 14610122 61 39 61 20 37 2 14 4 4 0 0.388 1.000 1.000 498 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(3), APAF1(3), ATM(11), BAD(2), BID(1), CASP3(1), CASP6(2), CASP9(1), EIF2S1(3), PRKCA(3), PTK2(2), PXN(2), STAT1(2), TLN1(3), TP53(12) 8062868 51 37 48 13 32 1 9 2 7 0 0.408 1.000 1.000 499 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 31 APAF1(3), BID(1), BIRC2(2), BIRC3(1), CASP10(1), CASP3(1), CASP6(2), CASP8(9), CASP9(1), CHUK(2), DFFA(1), DFFB(1), FADD(1), GAS2(2), NFKB1(2), NFKBIA(2), RELA(7), RIPK1(2), SPTAN1(11), TNFRSF10A(1), TNFRSF10B(1), TNFSF10(2), TRAF2(1) 9678869 57 37 55 17 25 3 10 5 14 0 0.611 1.000 1.000 500 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ACAT1(2), ACAT2(1), ACMSD(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), AOC2(1), AOC3(3), AOX1(3), ASMT(1), CAT(2), CYP19A1(1), CYP1A1(1), CYP1A2(1), CYP2A13(1), CYP2A6(2), CYP2A7(5), CYP2C18(3), CYP2C19(1), CYP2C9(3), CYP2E1(1), CYP2F1(1), CYP2J2(2), CYP3A5(2), CYP3A7(1), DDC(2), EHHADH(1), GCDH(2), HAAO(2), KMO(1), MAOA(1), MAOB(3), SDS(1), TPH1(2), WARS(1), WARS2(1) 15999638 69 37 69 21 46 3 13 4 3 0 0.240 1.000 1.000 501 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(11), ATR(6), BRCA1(5), BRCA2(6), CHEK1(1), CHEK2(1), FANCA(4), FANCD2(3), FANCF(1), FANCG(1), MRE11A(1), RAD17(1), RAD51(1), TP53(12) 12847156 54 36 52 11 34 0 8 3 9 0 0.380 1.000 1.000 502 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ALDH4A1(3), ALDH5A1(1), CAD(8), CPS1(1), EPRS(7), GAD1(4), GCLM(1), GFPT1(3), GLS2(2), GLUD1(2), GLUL(1), GMPS(2), GOT2(1), GPT2(2), NADSYN1(5), PPAT(1), QARS(2) 9684260 46 36 46 15 26 0 11 4 5 0 0.565 1.000 1.000 503 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(5), ACTG2(1), ADCY3(1), ADCY9(8), ARF4(1), ARF6(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(1), ATP6V1C2(1), ATP6V1E2(1), ATP6V1F(1), GNAS(6), PDIA4(1), PLCG1(3), PLCG2(4), PRKCA(3), SEC61A2(2), TRIM23(1) 10761575 49 36 49 18 29 0 11 3 6 0 0.563 1.000 1.000 504 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(4), COL4A2(4), COL4A3(4), COL4A4(2), COL4A5(3), COL4A6(4), F10(1), F11(1), F12(1), F2R(1), F5(7), F8(9), F9(3), FGA(6), FGG(1), KLKB1(2), PROS1(2), SERPINC1(1), SERPING1(2) 13196643 58 36 57 20 29 5 14 3 6 1 0.932 1.000 1.000 505 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 38 ATF2(2), CDC42(1), CREB1(2), DAXX(2), DDIT3(1), ELK1(2), HRAS(1), HSPB1(1), MAP3K1(4), MAP3K5(11), MAP3K9(5), MAPKAPK2(2), MAPKAPK5(1), MAX(2), MEF2A(1), MEF2B(1), MEF2C(1), MEF2D(3), MKNK1(1), MYC(1), PLA2G4A(3), RAC1(1), RIPK1(2), RPS6KA5(2), STAT1(2), TGFB2(1), TGFB3(2), TGFBR1(1), TRAF2(1) 10735166 60 36 60 18 36 3 11 6 4 0 0.654 1.000 1.000 506 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(3), EGFR(7), IGF1R(3), MYC(1), POLR2A(5), PRKCA(3), RB1(9), TEP1(8), TERF1(5), TERT(1), TNKS(2), TP53(12) 8183597 59 36 57 27 32 4 13 2 7 1 0.916 1.000 1.000 507 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(2), BTK(4), CALM1(2), CALM3(1), CD79A(1), CD79B(1), ELK1(2), FOS(2), HRAS(1), JUN(2), MAP2K1(2), MAP3K1(4), MAPK3(1), MAPK8(1), NFATC1(4), NFATC2(4), NFATC3(5), NFATC4(3), PLCG1(3), PPP3CA(1), PPP3CC(1), PRKCA(3), RAC1(1), SOS1(5), SYK(1), SYT1(2), VAV1(2) 10969230 61 35 61 20 34 4 16 3 4 0 0.680 1.000 1.000 508 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(7), ELK1(2), GNAS(6), GNB1(1), GNGT1(1), HRAS(1), IGF1R(3), ITGB1(2), KLK2(3), MAP2K1(2), MAPK1(9), MAPK3(1), MKNK1(1), MKNK2(2), MYC(1), NGFR(1), PDGFRA(2), PTPRR(1), RPS6KA1(1), RPS6KA5(2), SOS1(5), STAT3(2) 9608619 56 35 49 19 34 2 11 3 6 0 0.615 1.000 1.000 509 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(3), ALDOB(1), ALDOC(1), DLAT(2), ENO1(3), ENO3(4), G6PC(3), GAPDH(1), GAPDHS(2), GCK(2), GOT2(1), GPI(3), HK1(2), HK2(4), HK3(1), LDHAL6B(1), LDHC(3), MDH1(1), MDH2(1), PC(1), PDHA1(1), PDHA2(4), PDHB(2), PDHX(2), PGAM1(1), PGK1(1), PGK2(1), PKLR(3) 12431282 55 35 54 17 29 3 11 4 8 0 0.300 1.000 1.000 510 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(3), ADSS(1), ADSSL1(2), AGXT(1), ASL(2), ASPA(1), ASS1(2), CAD(8), CRAT(1), DARS2(2), DDO(1), DLAT(2), GAD1(4), GOT2(1), GPT2(2), NARS2(3), PC(1), PDHA1(1), PDHA2(4), PDHB(2) 11133831 44 35 43 14 21 1 15 3 4 0 0.518 1.000 1.000 511 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDH(3), AASS(2), ACAT1(2), ACAT2(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), BBOX1(4), DOT1L(6), EHHADH(1), EHMT1(5), EHMT2(3), GCDH(2), PLOD1(2), PLOD3(1), SDS(1), SHMT1(2), SHMT2(1), TMLHE(1) 10249203 50 35 50 16 31 1 8 4 6 0 0.497 1.000 1.000 512 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 CALM1(2), CALM3(1), GNAQ(2), HRAS(1), JUN(2), MAP2K1(2), MAP2K3(2), MAP3K1(4), MAPK1(9), MAPK3(1), MAPK8(1), PAK1(1), PLCG1(3), PRKCA(3), PTK2B(3), RAC1(1), SOS1(5), SYT1(2) 8271187 45 35 39 14 29 2 9 3 2 0 0.552 1.000 1.000 513 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(1), G6PC(3), G6PC2(1), GAA(4), GALK1(2), GALK2(1), GALT(2), GANC(1), GCK(2), GLA(1), GLB1(4), HK1(2), HK2(4), HK3(1), HSD3B7(1), LCT(3), MGAM(12), PGM3(1), RDH13(1), UGP2(2) 11304369 49 34 48 19 25 5 8 3 8 0 0.610 1.000 1.000 514 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(3), AKT2(1), AKT3(3), APC(7), AXIN2(2), CTNNB1(5), DACT1(3), DKK1(1), DKK3(1), FSTL1(2), GSK3A(3), LRP1(5), MVP(2), NKD1(1), NKD2(1), PIN1(1), PSEN1(4), PTPRA(2), SENP2(1), WIF1(1) 11808799 49 34 46 26 28 1 8 8 4 0 0.990 1.000 1.000 515 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 33 GTF2A1(1), GTF2A2(1), GTF2E1(1), GTF2H3(1), GTF2H4(1), GTF2I(3), GTF2IRD1(2), TAF1(8), TAF10(1), TAF1L(11), TAF2(1), TAF4(4), TAF5(2), TAF5L(2), TAF6(1), TAF6L(2), TAF7L(4), TAF9(4), TAF9B(1), TBPL1(2), TBPL2(1) 10377708 54 33 54 17 26 3 10 8 7 0 0.759 1.000 1.000 516 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 32 CD14(3), CHUK(2), ELK1(2), FOS(2), IKBKB(2), IRAK1(3), JUN(2), LY96(2), MAP2K3(2), MAP3K1(4), MAPK8(1), NFKB1(2), NFKBIA(2), PPARA(1), RELA(7), TLR10(3), TLR2(2), TLR3(5), TLR4(2), TLR7(4), TLR9(2), TOLLIP(1), TRAF6(1) 10721358 57 33 57 18 33 5 10 4 5 0 0.603 1.000 1.000 517 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH4A1(3), ALDH9A1(2), AMD1(5), AOC2(1), AOC3(3), ASL(2), CKB(1), CKM(1), CKMT2(2), CPS1(1), DAO(1), GLUD1(2), GOT2(1), MAOA(1), MAOB(3), NOS1(2), NOS3(6), ODC1(2), OTC(1), P4HA2(3), P4HB(2), SMS(1) 12910680 58 32 58 19 35 0 10 5 8 0 0.448 1.000 1.000 518 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(1), CHIA(3), CYB5R1(2), CYB5R3(1), GFPT1(3), GFPT2(5), GNE(3), GNPNAT1(1), HEXB(2), HK1(2), HK2(4), HK3(1), MTMR1(3), MTMR2(1), MTMR6(1), NPL(1), PGM3(1), PHPT1(1), UAP1(2) 8455895 38 32 38 13 20 2 7 2 7 0 0.646 1.000 1.000 519 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(3), ACADS(3), ACAT1(2), ACAT2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH5A1(1), ALDH9A1(2), BDH1(1), DDHD1(2), EHHADH(1), GAD1(4), HADH(1), HMGCS1(1), HSD17B10(1), HSD17B4(10), HSD3B7(1), L2HGDH(1), PDHA1(1), PDHA2(4), PDHB(2), PLA1A(2), PPME1(2), RDH13(1) 11845435 54 32 53 15 30 4 7 8 5 0 0.313 1.000 1.000 520 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(1), CAPN1(5), CAPNS1(1), CXCR3(1), EGF(1), EGFR(7), HRAS(1), ITGA1(3), ITGB1(2), MAPK1(9), MAPK3(1), MYLK(2), PRKAR2A(1), PTK2(2), PXN(2), TLN1(3) 9753138 42 32 36 18 24 2 12 1 3 0 0.840 1.000 1.000 521 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(4), DLG4(2), EPHB2(3), F2RL2(1), F2RL3(2), JUN(2), MAPK1(9), MAPK7(2), MAPK8(1), MYEF2(1), PLD1(3), PTK2(2), RASAL1(1), VAV1(2) 8031347 35 32 29 11 18 1 9 3 4 0 0.489 1.000 1.000 522 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B4GALT5(1), C1GALT1C1(4), GALNT1(1), GALNT11(2), GALNT13(1), GALNT14(3), GALNT3(1), GALNT4(2), GALNT5(2), GALNT6(1), GALNT7(2), GALNT9(4), GALNTL5(1), GCNT3(1), GCNT4(1), OGT(4), ST3GAL1(2), ST3GAL2(1), ST6GALNAC1(2), WBSCR17(5) 9442426 41 31 41 17 21 3 8 4 5 0 0.838 1.000 1.000 523 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(3), ADRA1B(2), ADRA1D(1), ADRA2C(1), ADRB2(2), CHRM1(1), CHRM2(3), CHRM3(3), CHRM4(1), CHRM5(1), DRD3(2), HRH1(2), HRH2(1), HTR1A(4), HTR1B(2), HTR1D(1), HTR1F(2), HTR2B(2), HTR2C(2), HTR4(1), HTR5A(1), HTR6(3), HTR7(2) 7363484 43 31 43 31 19 1 17 2 4 0 0.960 1.000 1.000 524 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 37 ERCC3(1), GTF2A2(1), GTF2E1(1), GTF2H4(1), POLR1A(7), POLR1B(3), POLR2A(5), POLR2B(3), POLR2C(1), POLR2F(1), POLR2H(1), POLR3B(3), POLR3D(1), POLR3E(3), TAF5(2), TAF6(1), TAF9(4), TBP(1) 10091946 40 31 40 27 26 3 3 3 4 1 1.000 1.000 1.000 525 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(1), ARSE(1), ASAH1(2), B4GALT6(1), CERK(3), DEGS1(1), ENPP7(2), GAL3ST1(2), GALC(1), GLA(1), GLB1(4), LCT(3), NEU1(2), PPAP2B(4), SGMS1(1), SGPP1(1), SMPD1(3), SMPD2(1), SMPD4(2), SPHK1(1), SPHK2(1), SPTLC1(1), SPTLC2(2), UGCG(2) 9991567 43 30 43 23 25 4 7 1 6 0 0.944 1.000 1.000 526 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(1), ADRBK2(2), CALM1(2), CALM3(1), CALML6(1), CAMK2A(3), CAMK2B(1), CAMK2D(2), CLCA2(1), CLCA4(3), CNGA3(3), CNGA4(3), CNGB1(5), GNAL(2), PDE1C(6), PRKACA(2), PRKG2(3) 8974409 41 30 41 20 18 5 13 3 2 0 0.934 1.000 1.000 527 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(1), BIRC2(2), BIRC3(1), CASP3(1), CASP8(9), FADD(1), JUN(2), MAP3K3(1), NFKB1(2), NFKB2(1), NFKBIA(2), NFKBIE(2), NR2C2(1), RALBP1(3), RIPK1(2), TNFAIP3(2), TNFRSF1A(4), TNFRSF1B(2), TRAF2(1) 7683153 40 30 39 15 17 4 7 2 10 0 0.828 1.000 1.000 528 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(3), CAMK2B(1), CAMK2D(2), DAG1(3), ITPKA(1), ITPKB(1), ITPR1(8), ITPR2(5), ITPR3(2), NFAT5(5), PDE6A(1), PDE6B(1), PDE6C(2), PDE6D(2), SLC6A13(2) 10565980 39 30 39 21 22 1 11 2 3 0 0.962 1.000 1.000 529 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 APC(7), ATF2(2), BMP4(2), BMP5(1), BMPR1A(1), BMPR2(3), CHRD(3), CTNNB1(5), FZD1(1), MEF2C(1), NPPA(1), RFC1(2), TGFB2(1), TGFB3(2), TGFBR1(1), TGFBR2(5), WNT1(1) 10402767 39 29 37 14 19 1 7 6 6 0 0.853 1.000 1.000 530 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(3), CALCRL(1), CD97(2), CRHR1(2), CRHR2(2), ELTD1(2), EMR2(3), GIPR(3), GLP1R(1), GPR64(5), LPHN1(3), LPHN2(4), LPHN3(10), SCTR(1), VIPR2(1) 8057328 43 29 43 19 22 4 12 2 3 0 0.676 1.000 1.000 531 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(3), ASL(2), ASS1(2), CKB(1), CKM(1), CKMT2(2), CPS1(1), DAO(1), EPRS(7), GLUD1(2), GLUD2(1), GOT2(1), LAP3(1), NOS1(2), NOS3(6), OTC(1), P4HA2(3), PRODH(1), RARS2(5) 10565516 43 29 42 20 26 1 7 2 7 0 0.906 1.000 1.000 532 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(2), ALG13(6), ALG6(3), ALG8(3), ALG9(1), B4GALT3(1), DPAGT1(1), FUT8(3), GANAB(4), MAN1A1(1), MAN1A2(1), MAN1B1(3), MAN1C1(3), MAN2A1(3), MGAT2(1), MGAT3(3), MGAT5(2), MGAT5B(1), RFT1(1), RPN1(2), ST6GAL1(2) 12170320 47 29 46 13 25 4 10 1 7 0 0.357 1.000 1.000 533 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ACACA(5), ACACB(6), ACADM(4), ACAT1(2), ACAT2(1), ACSS1(3), ACSS2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), EHHADH(1), HIBCH(1), LDHAL6A(1), LDHAL6B(1), LDHC(3), PCCA(1), SUCLA2(1), SUCLG1(1), SUCLG2(1) 11545930 43 29 43 15 25 2 4 7 5 0 0.649 1.000 1.000 534 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ADC(1), AGMAT(1), ALDH18A1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), AMD1(5), AOC2(1), AOC3(3), ASL(2), ASS1(2), CPS1(1), MAOA(1), MAOB(3), NAGS(2), ODC1(2), OTC(1), SAT1(1), SMS(1), SRM(1) 8553566 38 28 38 12 23 0 7 4 4 0 0.448 1.000 1.000 535 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3D(2), CXCR3(1), ETV5(2), IFNG(1), IL12A(2), IL12B(2), IL12RB1(1), IL12RB2(2), IL18R1(2), JAK2(6), JUN(2), MAPK8(1), STAT4(4), TYK2(9) 5499326 37 28 37 11 20 4 4 1 6 2 0.561 1.000 1.000 536 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(2), IKBKB(2), IL1A(2), IL1R1(2), IL1RAP(5), IL6(1), IRAK1(3), IRAK2(1), IRAK3(2), JUN(2), MAP2K3(2), MAP3K1(4), MAPK8(1), NFKB1(2), NFKBIA(2), RELA(7), TGFB2(1), TGFB3(2), TOLLIP(1), TRAF6(1) 8676732 45 28 44 17 24 1 8 4 8 0 0.871 1.000 1.000 537 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(6), C5(3), C6(5), C7(3), IL1A(2), IL6(1), IL8(2), ITGA4(6), ITGAL(4), ITGB1(2), VCAM1(2) 7204753 36 28 36 13 18 5 9 1 3 0 0.738 1.000 1.000 538 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ACAA2(1), ACADM(4), ACADS(3), ACAT1(2), ACAT2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), AOX1(3), AUH(1), BCAT1(1), BCAT2(2), BCKDHA(1), BCKDHB(1), DBT(1), EHHADH(1), HADH(1), HIBCH(1), HMGCS1(1), HSD17B10(1), HSD17B4(10), PCCA(1) 12549184 46 27 46 13 25 3 6 6 6 0 0.482 1.000 1.000 539 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 ALOX12(2), ALOX12B(1), ALOX15B(2), ALOX5(3), CBR3(1), CYP2C18(3), CYP2C19(1), CYP2C9(3), CYP2E1(1), CYP2J2(2), CYP2U1(1), CYP4A22(2), CYP4F3(1), EPHX2(2), PLA2G12A(1), PLA2G12B(3), PLA2G2D(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PTGS2(2) 11451691 38 27 38 22 28 0 5 1 4 0 0.886 1.000 1.000 540 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(1), ACTN1(1), ACTN2(2), CAPN1(5), CAPNS1(1), ITGA1(3), ITGB1(2), ITGB3(3), PTK2(2), PXN(2), RAC1(1), SPTAN1(11), TLN1(3) 8475279 37 27 36 15 16 2 10 1 8 0 0.809 1.000 1.000 541 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(2), CHUK(2), IFNG(1), IKBKB(2), JUN(2), MAP3K1(4), MAP3K5(11), MAP4K5(4), MAPK8(1), NFKB1(2), NFKBIA(2), RELA(7), TRAF2(1) 5755104 41 26 41 10 25 1 7 3 5 0 0.455 1.000 1.000 542 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(1), AZIN1(3), CBX3(1), CRY1(1), CRY2(1), DNAJA1(1), ETV6(2), GFRA1(3), HERPUD1(1), HSPA8(5), IDI1(1), KLF9(1), MYF6(4), NCKAP1(3), NCOA4(1), NR1D2(2), PER1(3), PER2(1), PURA(1), SF3A3(1), SUMO3(2), UGP2(2), ZFR(1) 10593418 42 26 42 16 26 1 9 3 3 0 0.896 1.000 1.000 543 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(3), ACO1(2), FH(1), IDH3A(2), IDH3B(1), IDH3G(1), MDH1(1), MDH2(1), OGDH(4), OGDHL(3), PC(1), PCK2(1), SDHA(4), SDHB(1), SDHD(1), SUCLA2(1), SUCLG1(1), SUCLG2(1) 8784451 30 26 30 10 17 0 7 0 6 0 0.492 1.000 1.000 544 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 26 ALDH1A3(2), ALDH3A1(1), AOC2(1), AOC3(3), DDC(2), EPX(4), ESCO1(1), ESCO2(1), GOT2(1), HPD(2), LPO(2), MAOA(1), MAOB(3), MPO(2), NAT6(1), PNPLA3(1), SH3GLB1(2), TAT(3), TPO(6) 9840841 39 26 39 13 23 1 10 3 2 0 0.559 1.000 1.000 545 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 22 POLR1A(7), POLR1B(3), POLR1C(3), POLR2A(5), POLR2B(3), POLR2C(1), POLR2F(1), POLR2H(1), POLR2L(1), POLR3A(1), POLR3B(3), POLR3G(2) 6751317 31 25 31 15 23 1 4 2 1 0 0.944 1.000 1.000 546 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(11), BMPR1B(2), DAZL(2), DMC1(1), EGR1(3), FSHR(2), LHCGR(1), MLH1(1), MSH5(2), NCOR1(5), NRIP1(4), PGR(2), PRLR(1), SMPD1(3), VDR(1), ZP2(4) 9917525 45 25 44 15 26 3 6 3 7 0 0.760 1.000 1.000 547 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(7), BTRC(1), CCND1(1), CREBBP(15), CSNK1D(2), CTBP1(1), CTNNB1(5), FZD1(1), MYC(1), PPARD(2), WIF1(1), WNT1(1) 8543639 38 25 35 12 20 1 8 3 5 1 0.723 1.000 1.000 548 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(2), DDX20(3), E2F4(1), ETS2(1), FOS(2), HDAC5(2), HRAS(1), JUN(2), NCOR2(6), RBL1(3), RBL2(2), SIN3A(3), SIN3B(2) 7937218 30 24 30 10 15 1 6 3 5 0 0.639 1.000 1.000 549 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(1), ALDOA(3), ALDOB(1), ALDOC(1), FPGT(2), FUK(2), GMDS(1), GMPPA(1), HK1(2), HK2(4), HK3(1), HSD3B7(1), KHK(2), MTMR1(3), MTMR2(1), MTMR6(1), PFKFB1(1), PFKFB2(1), PGM2(1), PHPT1(1), PMM2(1), RDH13(1) 11080115 33 24 33 14 17 2 9 1 4 0 0.694 1.000 1.000 550 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(2), GLB1(4), HEXB(2), LCT(3), SLC33A1(3), ST3GAL1(2), ST3GAL2(1), ST3GAL5(2), ST6GALNAC3(3), ST6GALNAC5(1), ST6GALNAC6(3), ST8SIA1(2), ST8SIA5(1) 4729652 29 24 29 12 11 2 11 1 4 0 0.650 1.000 1.000 551 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 ELK1(2), FOS(2), HRAS(1), IL6(1), IL6R(3), IL6ST(2), JAK1(1), JAK2(6), JAK3(4), JUN(2), MAP2K1(2), MAPK3(1), SOS1(5), STAT3(2) 6942295 34 24 34 10 17 2 8 1 5 1 0.506 1.000 1.000 552 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(3), AP2A1(3), AP2M1(2), BAD(2), BTK(4), EEA1(3), GRASP(1), GSK3A(3), PDPK1(2), PLCG1(3), PRKCE(1), PRKCZ(1), RAB5A(1), RAC1(1), RPS6KB1(1), VAV2(3) 7468091 34 24 33 17 16 1 10 3 4 0 0.901 1.000 1.000 553 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 CASP2(2), CHUK(2), IKBKB(2), JUN(2), MAP2K3(2), MAP3K1(4), MAP4K2(2), MAPK8(1), NFKB1(2), NFKBIA(2), RELA(7), RIPK1(2), TANK(3), TNFRSF1A(4), TRAF2(1) 6911551 38 24 38 18 23 2 6 2 5 0 0.957 1.000 1.000 554 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(3), CARS(1), EPRS(7), FARS2(1), GARS(1), LARS(3), LARS2(1), MARS(2), MARS2(2), QARS(2), SARS(1), TARS(2), WARS(1), WARS2(1), YARS(2) 9274141 30 23 30 12 22 0 4 2 2 0 0.816 1.000 1.000 555 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(3), AGT(2), EDN1(1), EDNRA(1), EDNRB(2), EGF(1), EGFR(7), FOS(2), HRAS(1), JUN(2), MYC(1), NFKB1(2), PLCG1(3), PRKCA(3), RELA(7) 5930869 38 23 38 12 21 1 10 1 5 0 0.481 1.000 1.000 556 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 66 RPL11(1), RPL13A(2), RPL18(1), RPL27(1), RPL28(3), RPL29(2), RPL3(2), RPL31(1), RPL35(1), RPL6(2), RPL8(1), RPL9(1), RPS10(1), RPS13(2), RPS2(1), RPS21(1), RPS23(1), RPS24(1), RPS25(1), RPS3A(1), RPS5(1), RPS7(1), RPS9(1) 6572674 30 23 30 12 21 1 3 0 5 0 0.591 1.000 1.000 557 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(2), FADD(1), IKBKB(2), IL1A(2), IL1R1(2), IRAK1(3), MAP3K1(4), NFKB1(2), NFKBIA(2), RELA(7), RIPK1(2), TLR4(2), TNFAIP3(2), TNFRSF1A(4), TNFRSF1B(2), TRAF6(1) 6912248 40 23 40 12 20 3 6 3 8 0 0.639 1.000 1.000 558 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(2), ALDH3A1(1), AOC2(1), AOC3(3), DDC(2), EPX(4), GOT2(1), HPD(2), LPO(2), MAOA(1), MAOB(3), MPO(2), PRDX1(1), TAT(3), TPO(6) 6411621 34 23 34 13 20 1 9 2 2 0 0.511 1.000 1.000 559 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 18 CHUK(2), DUSP1(1), IKBKAP(3), IKBKB(2), MAP3K1(4), NFKB1(2), NFKBIA(2), RELA(7), RIPK1(2), TANK(3), TNFAIP3(2), TNFRSF1B(2), TRAF1(1), TRAF2(1), TRAF3(3) 6586389 37 23 36 12 23 2 8 2 2 0 0.639 1.000 1.000 560 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(3), ADSS(1), AGXT(1), ASL(2), ASPA(1), CAD(8), CRAT(1), DDO(1), GAD1(4), GOT2(1), GPT2(2), PC(1) 7679194 26 22 26 12 12 0 11 1 2 0 0.845 1.000 1.000 561 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(1), ARSE(1), ASAH1(2), GAL3ST1(2), GALC(1), GLA(1), GLB1(4), LCT(3), NEU1(2), PPAP2B(4), SMPD1(3), SMPD2(1), SPTLC1(1), SPTLC2(2), UGCG(2) 6678001 30 22 30 12 16 3 5 1 5 0 0.750 1.000 1.000 562 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT2(1), AGPAT4(1), AGPAT6(1), AGPS(2), CHPT1(1), ENPP2(8), ENPP6(1), PAFAH1B1(2), PAFAH1B2(1), PLA2G12A(1), PLA2G12B(3), PLA2G2D(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLD1(3), PPAP2B(4) 6765936 36 22 36 13 20 1 4 6 5 0 0.651 1.000 1.000 563 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX5(3), CYP1A2(1), CYP2C18(3), CYP2C19(1), CYP2C9(3), CYP2E1(1), CYP2J2(2), CYP3A43(2), CYP3A5(2), CYP3A7(1), HSD3B7(1), PLA2G12A(1), PLA2G12B(3), PLA2G2D(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), RDH13(1) 6999910 32 22 32 13 22 0 7 1 2 0 0.573 1.000 1.000 564 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ACADM(4), ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), AOC2(1), AOC3(3), DPYD(3), DPYS(1), EHHADH(1), GAD1(4), SDS(1), SMS(1) 8348369 32 21 32 13 17 1 4 5 5 0 0.780 1.000 1.000 565 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CARM1(1), CBS(1), HEMK1(1), LCMT1(4), LCMT2(1), MARS(2), MARS2(2), MAT1A(1), METTL2B(1), PAPSS1(1), PAPSS2(2), PRMT2(1), PRMT5(1), PRMT6(1), PRMT7(3), SCLY(1), SEPHS1(1), SEPHS2(2) 7201356 27 21 27 15 16 1 7 1 2 0 0.930 1.000 1.000 566 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(2), AP2A1(3), AP2M1(2), BIN1(2), CALM1(2), CALM3(1), DNM1(1), EPS15(5), PICALM(2), PPP3CA(1), PPP3CC(1), SYNJ1(2), SYNJ2(1), SYT1(2) 6597059 27 21 27 11 17 2 2 3 3 0 0.843 1.000 1.000 567 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ACACA(5), ACADM(4), ACAT1(2), ACAT2(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), EHHADH(1), LDHC(3), PCCA(1), SDS(1), SUCLA2(1), SUCLG1(1), SUCLG2(1) 9639174 34 21 34 17 19 2 3 5 5 0 0.961 1.000 1.000 568 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(2), CALM3(1), CHUK(2), EGR3(1), GNAQ(2), MAP3K1(4), MYC(1), NFATC1(4), NFATC2(4), NFKB1(2), NFKBIA(2), PLCG1(3), PPP3CA(1), PPP3CC(1), PRKAR2A(1), RELA(7), SYT1(2), VIP(2), VIPR2(1) 7884657 43 21 43 15 27 5 6 3 2 0 0.729 1.000 1.000 569 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 AGT(2), AGTR1(1), COL4A1(4), COL4A2(4), COL4A3(4), COL4A4(2), COL4A5(3), COL4A6(4), REN(1) 7607127 25 20 25 16 13 3 6 1 2 0 0.999 1.000 1.000 570 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 GALNS(2), GLB1(4), GNS(3), GUSB(4), HEXB(2), IDS(8), LCT(3), NAGLU(1) 4204801 27 20 27 10 16 2 5 2 2 0 0.607 1.000 1.000 571 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 ELK1(2), FOS(2), HRAS(1), JAK1(1), JAK3(4), JUN(2), MAP2K1(2), MAPK3(1), MAPK8(1), SOS1(5), STAT5A(2), STAT5B(1), SYK(1) 6852584 25 20 25 11 10 1 11 1 2 0 0.814 1.000 1.000 572 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA2(1), ANXA3(2), ANXA5(1), CYP11A1(3), EDN1(1), EDNRA(1), EDNRB(2), HPGD(3), HSD11B2(1), PLA2G4A(3), PRL(3), PTGDR(2), PTGER4(2), PTGFR(1), PTGS2(2) 5938997 28 20 28 18 14 3 4 4 3 0 0.982 1.000 1.000 573 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(1), GTF2A1(1), GTF2E1(1), HDAC3(3), NCOA1(4), NCOA2(2), NCOA3(1), NCOR2(6), POLR2A(5), RXRA(1), TBP(1) 7416999 26 20 25 11 13 0 9 1 2 1 0.875 1.000 1.000 574 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(2), GPLD1(2), PGAP1(4), PIGA(2), PIGG(2), PIGH(1), PIGK(2), PIGM(1), PIGN(1), PIGO(2), PIGQ(2), PIGU(2), PIGX(1) 7211021 24 19 24 10 14 1 7 1 1 0 0.656 1.000 1.000 575 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), BCAT2(2), COASY(1), DPYD(3), DPYS(1), ENPP1(2), ENPP3(5), PANK1(2), PANK3(2), PANK4(1), PPCDC(1) 4995785 21 19 21 13 10 0 3 4 4 0 0.982 1.000 1.000 576 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(2), CALM3(1), DLG4(2), GRIN2A(4), GRIN2B(3), GRIN2D(3), NOS1(2), PPP3CA(1), PPP3CC(1), PRKAR2A(1), PRKCA(3), SYT1(2) 7527471 25 19 25 18 16 1 3 3 2 0 0.989 1.000 1.000 577 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 ALOX12(2), ALOX5(3), CBR3(1), CYP4F3(1), EPX(4), LPO(2), MPO(2), PLA2G4A(3), PLA2G6(2), PRDX1(1), PTGS2(2), TPO(6) 8205937 29 19 29 24 17 1 8 1 2 0 0.996 1.000 1.000 578 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(5), APOA4(1), CETP(1), CYP7A1(2), DGAT1(2), HMGCR(1), LCAT(3), LDLR(1), LIPC(2), LPL(2), LRP1(5) 7935986 25 19 25 16 10 1 8 1 5 0 0.969 1.000 1.000 579 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA2(1), ACADM(4), ACADS(3), ACAT1(2), ACAT2(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), AOX1(3), BCAT1(1), BCKDHA(1), BCKDHB(1), EHHADH(1), PCCA(1), SDS(1) 10483315 33 19 33 15 16 2 6 4 5 0 0.928 1.000 1.000 580 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(4), COL4A2(4), COL4A3(4), COL4A4(2), COL4A5(3), COL4A6(4), P4HB(2), SLC2A1(1), SLC2A3(1) 7612062 25 19 25 17 14 2 6 1 2 0 0.999 1.000 1.000 581 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(3), JAK1(1), PTPRU(3), REG1A(2), STAT1(2), STAT2(3), TYK2(9) 3629750 23 18 23 12 17 0 2 3 0 1 0.850 1.000 1.000 582 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5R1(1), CSNK1D(2), GRM1(3), PLCB1(10), PPP3CA(1), PRKAR2A(1) 4641547 18 17 18 10 10 1 5 1 1 0 0.907 1.000 1.000 583 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1R(1), C1S(1), C2(1), C3(6), C5(3), C6(5), C7(3), C9(1), MASP1(1), MASP2(2) 6110623 24 17 24 10 13 3 5 1 2 0 0.852 1.000 1.000 584 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(3), ALDOB(1), ALDOC(1), G6PD(1), GPI(3), H6PD(2), PGD(2), PGM3(1), PRPS2(2), TKT(1), TKTL1(2), TKTL2(1) 7007259 20 17 20 11 9 2 7 1 1 0 0.874 1.000 1.000 585 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 37 ANPEP(1), G6PD(1), GCLM(1), GSR(1), GSTA2(2), GSTA3(2), GSTA4(1), GSTA5(1), GSTM2(1), GSTM4(1), GSTT1(2), GSTT2(1), GSTZ1(1), MGST3(1) 6585273 17 17 17 11 8 1 5 0 3 0 0.921 1.000 1.000 586 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 CAT(2), EPX(4), LPO(2), MPO(2), MTHFR(4), SHMT1(2), SHMT2(1), TPO(6) 3365087 23 17 23 13 12 1 7 1 2 0 0.921 1.000 1.000 587 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AOC2(1), AOC3(3), CES1(3), DDHD1(2), ESCO1(1), ESCO2(1), LIPA(1), NAT6(1), PLA1A(2), PNPLA3(1), PPME1(2), SH3GLB1(2) 7284045 20 17 20 6 13 1 3 3 0 0 0.626 1.000 1.000 588 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), COASY(1), DPYD(3), DPYS(1), ENPP1(2), ENPP3(5), PANK1(2), PANK3(2), PANK4(1) 3984650 18 17 18 11 7 0 3 4 4 0 0.983 1.000 1.000 589 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(3), POLR2A(5), POLR2B(3), POLR2C(1), POLR2F(1), POLR2H(1), POLR2L(1), POLRMT(5) 3820856 20 17 20 11 13 1 4 2 0 0 0.944 1.000 1.000 590 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(3), ALDOB(1), ALDOC(1), GOT2(1), GPT2(2), MDH1(1), MDH2(1), ME1(1), PGK1(1), PGK2(1), PKLR(3), TKT(1), TKTL1(2), TKTL2(1) 5827393 20 16 20 11 9 2 7 0 2 0 0.896 1.000 1.000 591 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(3), IFNAR2(2), JAK1(1), STAT1(2), STAT2(3), TYK2(9) 3150210 20 15 20 10 16 0 1 2 0 1 0.842 1.000 1.000 592 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 CAT(2), EPX(4), LPO(2), MPO(2), PRDX1(1), SHMT1(2), SHMT2(1), TPO(6) 3457636 20 15 20 14 12 1 6 0 1 0 0.966 1.000 1.000 593 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(1), GALNT3(1), GALNT4(2), GALNT6(1), GALNT7(2), GALNT9(4), ST3GAL1(2), ST3GAL2(1), WBSCR17(5) 4265542 19 15 19 11 10 1 5 2 1 0 0.941 1.000 1.000 594 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(4), GLI2(6), GLI3(4), PRKAR2A(1), SMO(1), SUFU(2) 4609486 18 15 18 7 10 1 5 2 0 0 0.703 1.000 1.000 595 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT1(1), B3GAT3(1), B4GALT7(1), CHPF(1), CHST11(2), CHST12(2), CHST14(1), CHST3(2), CHSY1(1), DSE(2), UST(1), XYLT2(1) 3630361 16 14 16 12 8 0 6 2 0 0 0.965 1.000 1.000 596 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 CA14(3), CA2(1), CA4(1), CA6(2), CA7(1), CA8(1), CPS1(1), GLS2(2), GLUD1(2), GLUD2(1), GLUL(1), HAL(1) 6126566 17 14 17 10 10 0 2 3 2 0 0.960 1.000 1.000 597 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(1), CD44(2), IL6R(3), SELL(1), SPN(1), TGFB2(1), TNFRSF1A(4), TNFRSF1B(2), TNFRSF8(3) 3819254 18 14 18 10 10 2 1 0 5 0 0.936 1.000 1.000 598 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ALDH18A1(1), ASL(2), CKB(1), CKM(1), CKMT2(2), CPS1(1), GLUD1(2), NAGS(2), ODC1(2), OTC(1), SMS(1) 5184008 16 14 16 12 10 0 1 1 4 0 0.988 1.000 1.000 599 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(1), CNR2(1), DNMT1(3), MTNR1A(1), MTNR1B(2), PTAFR(1), PTGDR(2), PTGER4(2), PTGFR(1), TBXA2R(1) 3124852 15 13 15 14 5 2 4 3 1 0 0.988 1.000 1.000 600 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(4), LPO(2), MPO(2), PRDX1(1), TPO(6), TYR(2) 2824320 17 13 17 13 10 1 6 0 0 0 0.981 1.000 1.000 601 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(2), MAPK8(1), NFKB1(2), RELA(7), TNFRSF13B(1), TNFSF13B(1), TRAF2(1), TRAF3(3), TRAF5(1), TRAF6(1) 4251709 20 13 19 11 13 1 3 1 2 0 0.971 1.000 1.000 602 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(4), LPO(2), MPO(2), TPO(6) 2437759 14 11 14 9 8 1 5 0 0 0 0.920 1.000 1.000 603 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CBS(1), MARS(2), MARS2(2), MAT1A(1), PAPSS1(1), PAPSS2(2), SCLY(1), SEPHS1(1) 3617396 11 10 11 9 7 0 3 1 0 0 0.972 1.000 1.000 604 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(2), ALOX15B(2), ALOX5(3), PLA2G6(2), PTGS2(2) 4535836 11 9 11 12 7 0 2 0 2 0 0.992 1.000 1.000 605 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(2), KHK(2), LCT(3), PYGM(1) 3928055 8 8 8 7 3 0 3 2 0 0 0.970 1.000 1.000 606 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(1), CKM(1), LDHC(3), NCL(3) 2656141 8 7 8 4 5 0 1 2 0 0 0.852 1.000 1.000 607 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(1), CRY1(1), CRY2(1), PER1(3) 2458205 6 6 6 5 5 0 1 0 0 0 0.977 1.000 1.000 608 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 LPL(2), NR3C1(4), PPARG(1), RXRA(1) 1586365 8 6 8 4 6 0 2 0 0 0 0.815 1.000 1.000 609 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(1), GOT2(1), LDHC(3) 1932330 5 5 5 4 4 0 0 1 0 0 0.946 1.000 1.000 610 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS2(2), GLUD1(2), GLUD2(1) 1301497 5 5 5 5 5 0 0 0 0 0 0.984 1.000 1.000 611 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ASL(2), CPS1(1), GLUD1(2) 2258638 5 5 5 5 3 0 1 1 0 0 0.983 1.000 1.000 612 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(2), ALDH1A2(2) 1127813 4 4 4 3 3 0 1 0 0 0 0.920 1.000 1.000 613 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOA(3), ALDOB(1), ALDOC(1) 1121872 5 4 5 3 3 1 1 0 0 0 0.840 1.000 1.000 614 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASS(2) 1379470 2 2 2 2 2 0 0 0 0 0 0.971 1.000 1.000 615 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 466418 0 0 0 2 0 0 0 0 0 0 1.000 1.000 1.000 616 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 147052 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000